4EA5A

Structure of the glycoslyase domain of mbd4 bound to a 5hmu containing dna
Total Genus 49
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
49
sequence length
136
structure length
136
Chain Sequence
TPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEAHKLNKYHDWLWENH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Biochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNA.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 49
structure length 136
sequence length 136
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-03-22
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ea5A00
3OGDA 4OFEA 1VRLA 5DPKA 3N5NX 3F0ZA 3I0XA 2I5WA 4E9GA 4EW0A 1N3CA 4OFHA 4EVVA 4EA4A 1FN7A 1MUNA 4AIAA 3CW7A 3F10A 3KNTA 2OFIA 4B22A 4EJYA 3S6IA 2JG6A 4UNFA 1PU6A 2YG9A 4EJZA 1MPGA 1NGNA 5CHZA 4HSBA 3IHOA 1WEGA 1KG2A 1LMZA 1WEIA 1ORNA 5KN8A 3CWUA 4YOQA 1RRSA 2NOEA 1LWYA 2NOLA 3CVTA 1PVSA 4YPHA 4B24A 1KG7A 1LWVA 1RRQA 4EA5A 3CVSA 1KEAA 1PU7A 1KQJA 1ORPA 4B23A 1NKUA 1N39A 1WEFA 1DIZA 4UOBA 2NOIA 3FHGA 2JHNA 3IH7A 3OH9A 3D4VA 4E9HA 2NOZA 1XG7A 2XHIA 3CWAA 1M3QA 1KG3A 2H56A 1YQKA 3FHFA 1N3AA 1YQLA 4E9EA 4E9FA 3G0QA 2ABKA 4EW4A 2OFKA 1XQOA 1KG6A 1EBMA 3CWSA 1KG4A 3CWTA 1P7MA 4AI5A 3FSPA 4B21A 4AI4A 1KG5A 5AN4A 1M3HA 3I0WA 2NOHA 2NOBA 1MUYA 4PIIA 1KO9A 2NOFA 1YQMA 1YQRA 3OH6A 5KN9A 1P59A 4DK9A 1PU8A 1XQPA 4YPRA 3KTUA 1LWWA 2YG8A 3N0UA 1HU0A 1MUDA 2JHJA 4OFAA
chains in the Genus database with same CATH superfamily
3OGDA 4OFEA 1VRLA 5DPKA 3N5NX 3F0ZA 3I0XA 3NNQA 2I5WA 4E9GA 4EW0A 1N3CA 4OFHA 4EVVA 4EA4A 3OYAA 1FN7A 1MUNA 2V75A 3OYFA 3OYKA 4AIAA 3CW7A 3F10A 3KNTA 3L2WA 3OYJA 3S3MA 4BDZA 2OFIA 2JPSA 4B22A 4EJYA 3S6IA 2JG6A 4UNFA 1PU6A 2W03A 2YG9A 4EJZA 1MPGA 1NGNA 5CHZA 4IKFA 3L2QA 4HSBA 3IHOA 3OYDA 1WEGA 1KG2A 4ZTJA 1LMZA 1WEIA 1ORNA 5KN8A 3CWUA 4YOQA 1RRSA 2NOEA 1U84A 1LWYA 2NOLA 3CVTA 1PVSA 4YPHA 3S3NA 4B24A 1KG7A 5FROA 3OYHA 1LWVA 1RRQA 4EA5A 3CVSA 1KEAA 1PU7A 4BE2A 4ZTFA 1KQJA 1ORPA 4B23A 3OS1A 4BDYA 1NKUA 1N39A 1WEFA 4E7IA 1DIZA 4UOBA 2NOIA 3OYMA 3FHGA 2JHNA 3IH7A 3S3OA 4E7LA 3OH9A 3D4VA 4E9HA 2NOZA 1XG7A 3VW4A 3OYNA 3OYBA 4BE1A 2XHIA 3CWAA 1M3QA 1KG3A 4BE0A 2H56A 1YQKA 3FHFA 1N3AA 3LCNA 1YQLA 4E9EA 3OS0A 4E9FA 4E7KA 3G0QA 2ABKA 4EW4A 2OFKA 1XQOA 1KG6A 1EBMA 2W04A 3CWSA 5FRNA 3R2XC 1KG4A 3CWTA 1P7MA 4AI5A 3FSPA 3L2RA 4B21A 3L2VA 4AI4A 4NZGA 4BACA 1KG5A 5AN4A 3OYGA 1M3HA 3OYIA 4E7JA 3I0WA 2NOHA 2NOBA 1MUYA 5FRMA 4PIIA 3OYLA 1KO9A 2NOFA 3OS2A 1YQMA 1YQRA 3L2UA 3OH6A 5KN9A 1P59A 4DK9A 1PU8A 1XQPA 4YPRA 3OYCA 3KTUA 1LWWA 2YG8A 3N0UA 3OY9A 1HU0A 1MUDA 2JHJA 3OYEA 4OFAA 4E7HA
chains in the Genus database with same CATH topology
3OGDA 4OFEA 1VRLA 5DPKA 3N5NX 3F0ZA 3I0XA 2I5WA 4E9GA 4EW0A 1N3CA 4OFHA 4EVVA 4EA4A 1FN7A 1MUNA 4AIAA 3CW7A 3F10A 3KNTA 2OFIA 4B22A 4EJYA 3S6IA 2JG6A 4UNFA 1PU6A 2YG9A 4EJZA 1MPGA 1NGNA 5CHZA 4HSBA 3IHOA 1WEGA 1KG2A 1LMZA 1WEIA 1ORNA 5KN8A 3CWUA 4YOQA 1RRSA 2NOEA 1LWYA 2NOLA 3CVTA 1PVSA 4YPHA 4B24A 1KG7A 1LWVA 1RRQA 4EA5A 3CVSA 1KEAA 1PU7A 1KQJA 1ORPA 4B23A 1NKUA 1N39A 1WEFA 1DIZA 4UOBA 2NOIA 3FHGA 2JHNA 3IH7A 3OH9A 3D4VA 4E9HA 2NOZA 1XG7A 2XHIA 3CWAA 1M3QA 1KG3A 2H56A 1YQKA 3FHFA 1N3AA 1YQLA 4E9EA 4E9FA 3G0QA 2ABKA 4EW4A 2OFKA 1XQOA 1KG6A 1EBMA 3CWSA 1KG4A 3CWTA 1P7MA 4AI5A 3FSPA 4B21A 4AI4A 1KG5A 5AN4A 1M3HA 3I0WA 2NOHA 2NOBA 1MUYA 4PIIA 1KO9A 2NOFA 1YQMA 1YQRA 3OH6A 5KN9A 1P59A 4DK9A 1PU8A 1XQPA 4YPRA 3KTUA 1LWWA 2YG8A 3N0UA 1HU0A 1MUDA 2JHJA 4OFAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3OGD A;  4OFE A;  1VRL A;  5DPK A;  3N5N X;  3F0Z A;  3I0X A;  2I5W A;  4E9G A;  4EW0 A;  1N3C A;  4OFH A;  4EVV A;  4EA4 A;  1FN7 A;  1MUN A;  4AIA A;  3CW7 A;  3F10 A;  3KNT A;  2OFI A;  4B22 A;  4EJY A;  3S6I A;  2JG6 A;  4UNF A;  1PU6 A;  2YG9 A;  4EJZ A;  1MPG A;  1NGN A;  5CHZ A;  4HSB A;  3IHO A;  1WEG A;  1KG2 A;  1LMZ A;  1WEI A;  1ORN A;  5KN8 A;  3CWU A;  4YOQ A;  1RRS A;  2NOE A;  1LWY A;  2NOL A;  3CVT A;  1PVS A;  4YPH A;  4B24 A;  1KG7 A;  1LWV A;  1RRQ A;  4EA5 A;  3CVS A;  1KEA A;  1PU7 A;  1KQJ A;  1ORP A;  4B23 A;  1NKU A;  1N39 A;  1WEF A;  1DIZ A;  4UOB A;  2NOI A;  3FHG A;  2JHN A;  3IH7 A;  3OH9 A;  3D4V A;  4E9H A;  2NOZ A;  1XG7 A;  2XHI A;  3CWA A;  1M3Q A;  1KG3 A;  2H56 A;  1YQK A;  3FHF A;  1N3A A;  1YQL A;  4E9E A;  4E9F A;  3G0Q A;  2ABK A;  4EW4 A;  2OFK A;  1XQO A;  1KG6 A;  1EBM A;  3CWS A;  1KG4 A;  3CWT A;  1P7M A;  4AI5 A;  3FSP A;  4B21 A;  4AI4 A;  1KG5 A;  5AN4 A;  1M3H A;  3I0W A;  2NOH A;  2NOB A;  1MUY A;  4PII A;  1KO9 A;  2NOF A;  1YQM A;  1YQR A;  3OH6 A;  5KN9 A;  1P59 A;  4DK9 A;  1PU8 A;  1XQP A;  4YPR A;  3KTU A;  1LWW A;  2YG8 A;  3N0U A;  1HU0 A;  1MUD A;  2JHJ A;  4OFA A; 
#chains in the Genus database with same CATH topology
 3OGD A;  4OFE A;  1VRL A;  5DPK A;  3N5N X;  3F0Z A;  3I0X A;  3NNQ A;  2I5W A;  4E9G A;  4EW0 A;  1N3C A;  4OFH A;  4EVV A;  4EA4 A;  3OYA A;  1FN7 A;  1MUN A;  2V75 A;  3OYF A;  3OYK A;  4AIA A;  3CW7 A;  3F10 A;  3KNT A;  3L2W A;  3OYJ A;  3S3M A;  4BDZ A;  2OFI A;  2JPS A;  4B22 A;  4EJY A;  3S6I A;  2JG6 A;  4UNF A;  1PU6 A;  2W03 A;  2YG9 A;  4EJZ A;  1MPG A;  1NGN A;  5CHZ A;  4IKF A;  3L2Q A;  4HSB A;  3IHO A;  3OYD A;  1WEG A;  1KG2 A;  4ZTJ A;  1LMZ A;  1WEI A;  1ORN A;  5KN8 A;  3CWU A;  4YOQ A;  1RRS A;  2NOE A;  1U84 A;  1LWY A;  2NOL A;  3CVT A;  1PVS A;  4YPH A;  3S3N A;  4B24 A;  1KG7 A;  5FRO A;  3OYH A;  1LWV A;  1RRQ A;  4EA5 A;  3CVS A;  1KEA A;  1PU7 A;  4BE2 A;  4ZTF A;  1KQJ A;  1ORP A;  4B23 A;  3OS1 A;  4BDY A;  1NKU A;  1N39 A;  1WEF A;  4E7I A;  1DIZ A;  4UOB A;  2NOI A;  3OYM A;  3FHG A;  2JHN A;  3IH7 A;  3S3O A;  4E7L A;  3OH9 A;  3D4V A;  4E9H A;  2NOZ A;  1XG7 A;  3VW4 A;  3OYN A;  3OYB A;  4BE1 A;  2XHI A;  3CWA A;  1M3Q A;  1KG3 A;  4BE0 A;  2H56 A;  1YQK A;  3FHF A;  1N3A A;  3LCN A;  1YQL A;  4E9E A;  3OS0 A;  4E9F A;  4E7K A;  3G0Q A;  2ABK A;  4EW4 A;  2OFK A;  1XQO A;  1KG6 A;  1EBM A;  2W04 A;  3CWS A;  5FRN A;  3R2X C;  1KG4 A;  3CWT A;  1P7M A;  4AI5 A;  3FSP A;  3L2R A;  4B21 A;  3L2V A;  4AI4 A;  4NZG A;  4BAC A;  1KG5 A;  5AN4 A;  3OYG A;  1M3H A;  3OYI A;  4E7J A;  3I0W A;  2NOH A;  2NOB A;  1MUY A;  5FRM A;  4PII A;  3OYL A;  1KO9 A;  2NOF A;  3OS2 A;  1YQM A;  1YQR A;  3L2U A;  3OH6 A;  5KN9 A;  1P59 A;  4DK9 A;  1PU8 A;  1XQP A;  4YPR A;  3OYC A;  3KTU A;  1LWW A;  2YG8 A;  3N0U A;  3OY9 A;  1HU0 A;  1MUD A;  2JHJ A;  3OYE A;  4OFA A;  4E7H A; 
#chains in the Genus database with same CATH homology
 3OGD A;  4OFE A;  1VRL A;  5DPK A;  3N5N X;  3F0Z A;  3I0X A;  2I5W A;  4E9G A;  4EW0 A;  1N3C A;  4OFH A;  4EVV A;  4EA4 A;  1FN7 A;  1MUN A;  4AIA A;  3CW7 A;  3F10 A;  3KNT A;  2OFI A;  4B22 A;  4EJY A;  3S6I A;  2JG6 A;  4UNF A;  1PU6 A;  2YG9 A;  4EJZ A;  1MPG A;  1NGN A;  5CHZ A;  4HSB A;  3IHO A;  1WEG A;  1KG2 A;  1LMZ A;  1WEI A;  1ORN A;  5KN8 A;  3CWU A;  4YOQ A;  1RRS A;  2NOE A;  1LWY A;  2NOL A;  3CVT A;  1PVS A;  4YPH A;  4B24 A;  1KG7 A;  1LWV A;  1RRQ A;  4EA5 A;  3CVS A;  1KEA A;  1PU7 A;  1KQJ A;  1ORP A;  4B23 A;  1NKU A;  1N39 A;  1WEF A;  1DIZ A;  4UOB A;  2NOI A;  3FHG A;  2JHN A;  3IH7 A;  3OH9 A;  3D4V A;  4E9H A;  2NOZ A;  1XG7 A;  2XHI A;  3CWA A;  1M3Q A;  1KG3 A;  2H56 A;  1YQK A;  3FHF A;  1N3A A;  1YQL A;  4E9E A;  4E9F A;  3G0Q A;  2ABK A;  4EW4 A;  2OFK A;  1XQO A;  1KG6 A;  1EBM A;  3CWS A;  1KG4 A;  3CWT A;  1P7M A;  4AI5 A;  3FSP A;  4B21 A;  4AI4 A;  1KG5 A;  5AN4 A;  1M3H A;  3I0W A;  2NOH A;  2NOB A;  1MUY A;  4PII A;  1KO9 A;  2NOF A;  1YQM A;  1YQR A;  3OH6 A;  5KN9 A;  1P59 A;  4DK9 A;  1PU8 A;  1XQP A;  4YPR A;  3KTU A;  1LWW A;  2YG8 A;  3N0U A;  1HU0 A;  1MUD A;  2JHJ A;  4OFA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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