4EVVA

Mouse mbd4 glycosylase domain in complex with a g:t mismatch
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
145
structure length
145
Chain Sequence
MKWTPPRSPFNLVQEILFHDPWKLLIATIFLNRTSGKMAIPVLWEFLEKYPSAEVARAADWRDVSELLKPLGLYDLRAKTIIKFSDEYLTKQWRYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation.
pubmed doi rcsb
molecule tags Hydrolase/dna
source organism Mus musculus
molecule keywords Methyl-CpG-binding domain protein 4
total genus 41
structure length 145
sequence length 145
ec nomenclature ec 3.2.2.-:
pdb deposition date 2012-04-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4evvA00
2NOEA 1WEGA 1HU0A 4EW4A 1MPGA 3CVTA 1N3AA 3OH6A 1KG2A 1XQPA 3FHFA 3F0ZA 2OFIA 3FSPA 1P59A 3CWUA 1RRSA 1KQJA 4B21A 1YQMA 1KG7A 4EJZA 4EW0A 2JHJA 1ORNA 3CVSA 4EJYA 3IHOA 1MUNA 3I0XA 1EBMA 3I0WA 2ABKA 1P7MA 4E9FA 1FN7A 1KG4A 3CWSA 3IH7A 1PU7A 2NOBA 1KG6A 1KG3A 2NOHA 4B23A 4E9GA 1PU6A 4EA5A 3KNTA 1LWYA 4B24A 1NKUA 1DIZA 4OFEA 4AIAA 1M3QA 2NOZA 3OGDA 4AI4A 5AN4A 1YQLA 4E9HA 2NOFA 1WEIA 1LWWA 3KTUA 5KN8A 1N39A 3N0UA 2JHNA 4E9EA 4UNFA 5CHZA 1PU8A 4EA4A 4EVVA 1MUYA 4UOBA 1ORPA 2YG9A 3OH9A 1YQRA 2JG6A 2NOLA 4DK9A 5DPKA 3S6IA 1XQOA 2NOIA 3N5NX 4HSBA 3CW7A 5KN9A 3G0QA 2XHIA 1RRQA 1KG5A 4B22A 4YPRA 4PIIA 2H56A 4OFHA 1MUDA 3FHGA 2I5WA 1LMZA 1M3HA 4YPHA 4YOQA 1VRLA 1N3CA 1NGNA 1KO9A 4OFAA 1WEFA 2YG8A 1XG7A 1LWVA 3F10A 1PVSA 1KEAA 2OFKA 3CWAA 3D4VA 3CWTA 4AI5A 1YQKA
chains in the Genus database with same CATH superfamily
4ZTFA 3L2QA 2NOEA 4BE0A 1WEGA 3OYCA 4EW4A 1HU0A 1MPGA 3CVTA 3OYHA 4NZGA 3VW4A 3OYIA 4E7KA 1N3AA 5FROA 3OH6A 3LCNA 3OY9A 1KG2A 1XQPA 3FHFA 3F0ZA 2OFIA 3FSPA 1P59A 3OYEA 3CWUA 3OS2A 1RRSA 1KQJA 4B21A 1YQMA 3L2RA 1KG7A 3L2UA 4EJZA 4EW0A 2JHJA 1ORNA 3CVSA 4EJYA 5FRMA 3IHOA 3NNQA 1MUNA 3I0XA 1EBMA 3I0WA 2ABKA 3L2WA 1P7MA 4E9FA 4BE1A 4E7IA 4E7JA 3OYLA 3OYBA 3OS0A 1KG4A 4ZTJA 1FN7A 3CWSA 3IH7A 3OYDA 1PU7A 4BACA 2NOBA 1KG6A 1KG3A 2NOHA 4B23A 4E9GA 1PU6A 4EA5A 3KNTA 1LWYA 3OYAA 4B24A 4IKFA 1NKUA 1DIZA 4OFEA 4AIAA 4BDYA 4E7HA 1M3QA 2NOZA 3OGDA 4AI4A 5AN4A 3OYMA 1YQLA 4E9HA 2NOFA 1WEIA 3OYFA 1LWWA 3KTUA 5KN8A 3OS1A 1N39A 3N0UA 2JHNA 4E9EA 4UNFA 5CHZA 1PU8A 1U84A 3R2XC 4EA4A 4EVVA 1MUYA 4UOBA 1ORPA 2YG9A 3OH9A 1YQRA 2JG6A 2NOLA 4DK9A 3S3MA 5DPKA 3S6IA 1XQOA 2NOIA 3N5NX 4HSBA 3CW7A 5KN9A 2W04A 2V75A 3G0QA 2XHIA 2JPSA 1RRQA 1KG5A 3OYKA 4B22A 4BDZA 4BE2A 4YPRA 5FRNA 4PIIA 2H56A 4OFHA 1MUDA 3FHGA 2I5WA 1LMZA 1M3HA 4YPHA 4YOQA 3OYGA 2W03A 1VRLA 1N3CA 1NGNA 4E7LA 1KO9A 4OFAA 1WEFA 3S3OA 2YG8A 1XG7A 3L2VA 3S3NA 1LWVA 3OYJA 3F10A 1PVSA 1KEAA 2OFKA 3CWAA 3D4VA 3CWTA 3OYNA 4AI5A 1YQKA
chains in the Genus database with same CATH topology
2NOEA 1WEGA 1HU0A 4EW4A 1MPGA 3CVTA 1N3AA 3OH6A 1KG2A 1XQPA 3FHFA 3F0ZA 2OFIA 3FSPA 1P59A 3CWUA 1RRSA 1KQJA 4B21A 1YQMA 1KG7A 4EJZA 4EW0A 2JHJA 1ORNA 3CVSA 4EJYA 3IHOA 1MUNA 3I0XA 1EBMA 3I0WA 2ABKA 1P7MA 4E9FA 1FN7A 1KG4A 3CWSA 3IH7A 1PU7A 2NOBA 1KG6A 1KG3A 2NOHA 4B23A 4E9GA 1PU6A 4EA5A 3KNTA 1LWYA 4B24A 1NKUA 1DIZA 4OFEA 4AIAA 1M3QA 2NOZA 3OGDA 4AI4A 5AN4A 1YQLA 4E9HA 2NOFA 1WEIA 1LWWA 3KTUA 5KN8A 1N39A 3N0UA 2JHNA 4E9EA 4UNFA 5CHZA 1PU8A 4EA4A 4EVVA 1MUYA 4UOBA 1ORPA 2YG9A 3OH9A 1YQRA 2JG6A 2NOLA 4DK9A 5DPKA 3S6IA 1XQOA 2NOIA 3N5NX 4HSBA 3CW7A 5KN9A 3G0QA 2XHIA 1RRQA 1KG5A 4B22A 4YPRA 4PIIA 2H56A 4OFHA 1MUDA 3FHGA 2I5WA 1LMZA 1M3HA 4YPHA 4YOQA 1VRLA 1N3CA 1NGNA 1KO9A 4OFAA 1WEFA 2YG8A 1XG7A 1LWVA 3F10A 1PVSA 1KEAA 2OFKA 3CWAA 3D4VA 3CWTA 4AI5A 1YQKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NOE A;  1WEG A;  1HU0 A;  4EW4 A;  1MPG A;  3CVT A;  1N3A A;  3OH6 A;  1KG2 A;  1XQP A;  3FHF A;  3F0Z A;  2OFI A;  3FSP A;  1P59 A;  3CWU A;  1RRS A;  1KQJ A;  4B21 A;  1YQM A;  1KG7 A;  4EJZ A;  4EW0 A;  2JHJ A;  1ORN A;  3CVS A;  4EJY A;  3IHO A;  1MUN A;  3I0X A;  1EBM A;  3I0W A;  2ABK A;  1P7M A;  4E9F A;  1FN7 A;  1KG4 A;  3CWS A;  3IH7 A;  1PU7 A;  2NOB A;  1KG6 A;  1KG3 A;  2NOH A;  4B23 A;  4E9G A;  1PU6 A;  4EA5 A;  3KNT A;  1LWY A;  4B24 A;  1NKU A;  1DIZ A;  4OFE A;  4AIA A;  1M3Q A;  2NOZ A;  3OGD A;  4AI4 A;  5AN4 A;  1YQL A;  4E9H A;  2NOF A;  1WEI A;  1LWW A;  3KTU A;  5KN8 A;  1N39 A;  3N0U A;  2JHN A;  4E9E A;  4UNF A;  5CHZ A;  1PU8 A;  4EA4 A;  4EVV A;  1MUY A;  4UOB A;  1ORP A;  2YG9 A;  3OH9 A;  1YQR A;  2JG6 A;  2NOL A;  4DK9 A;  5DPK A;  3S6I A;  1XQO A;  2NOI A;  3N5N X;  4HSB A;  3CW7 A;  5KN9 A;  3G0Q A;  2XHI A;  1RRQ A;  1KG5 A;  4B22 A;  4YPR A;  4PII A;  2H56 A;  4OFH A;  1MUD A;  3FHG A;  2I5W A;  1LMZ A;  1M3H A;  4YPH A;  4YOQ A;  1VRL A;  1N3C A;  1NGN A;  1KO9 A;  4OFA A;  1WEF A;  2YG8 A;  1XG7 A;  1LWV A;  3F10 A;  1PVS A;  1KEA A;  2OFK A;  3CWA A;  3D4V A;  3CWT A;  4AI5 A;  1YQK A; 
#chains in the Genus database with same CATH topology
 4ZTF A;  3L2Q A;  2NOE A;  4BE0 A;  1WEG A;  3OYC A;  4EW4 A;  1HU0 A;  1MPG A;  3CVT A;  3OYH A;  4NZG A;  3VW4 A;  3OYI A;  4E7K A;  1N3A A;  5FRO A;  3OH6 A;  3LCN A;  3OY9 A;  1KG2 A;  1XQP A;  3FHF A;  3F0Z A;  2OFI A;  3FSP A;  1P59 A;  3OYE A;  3CWU A;  3OS2 A;  1RRS A;  1KQJ A;  4B21 A;  1YQM A;  3L2R A;  1KG7 A;  3L2U A;  4EJZ A;  4EW0 A;  2JHJ A;  1ORN A;  3CVS A;  4EJY A;  5FRM A;  3IHO A;  3NNQ A;  1MUN A;  3I0X A;  1EBM A;  3I0W A;  2ABK A;  3L2W A;  1P7M A;  4E9F A;  4BE1 A;  4E7I A;  4E7J A;  3OYL A;  3OYB A;  3OS0 A;  1KG4 A;  4ZTJ A;  1FN7 A;  3CWS A;  3IH7 A;  3OYD A;  1PU7 A;  4BAC A;  2NOB A;  1KG6 A;  1KG3 A;  2NOH A;  4B23 A;  4E9G A;  1PU6 A;  4EA5 A;  3KNT A;  1LWY A;  3OYA A;  4B24 A;  4IKF A;  1NKU A;  1DIZ A;  4OFE A;  4AIA A;  4BDY A;  4E7H A;  1M3Q A;  2NOZ A;  3OGD A;  4AI4 A;  5AN4 A;  3OYM A;  1YQL A;  4E9H A;  2NOF A;  1WEI A;  3OYF A;  1LWW A;  3KTU A;  5KN8 A;  3OS1 A;  1N39 A;  3N0U A;  2JHN A;  4E9E A;  4UNF A;  5CHZ A;  1PU8 A;  1U84 A;  3R2X C;  4EA4 A;  4EVV A;  1MUY A;  4UOB A;  1ORP A;  2YG9 A;  3OH9 A;  1YQR A;  2JG6 A;  2NOL A;  4DK9 A;  3S3M A;  5DPK A;  3S6I A;  1XQO A;  2NOI A;  3N5N X;  4HSB A;  3CW7 A;  5KN9 A;  2W04 A;  2V75 A;  3G0Q A;  2XHI A;  2JPS A;  1RRQ A;  1KG5 A;  3OYK A;  4B22 A;  4BDZ A;  4BE2 A;  4YPR A;  5FRN A;  4PII A;  2H56 A;  4OFH A;  1MUD A;  3FHG A;  2I5W A;  1LMZ A;  1M3H A;  4YPH A;  4YOQ A;  3OYG A;  2W03 A;  1VRL A;  1N3C A;  1NGN A;  4E7L A;  1KO9 A;  4OFA A;  1WEF A;  3S3O A;  2YG8 A;  1XG7 A;  3L2V A;  3S3N A;  1LWV A;  3OYJ A;  3F10 A;  1PVS A;  1KEA A;  2OFK A;  3CWA A;  3D4V A;  3CWT A;  3OYN A;  4AI5 A;  1YQK A; 
#chains in the Genus database with same CATH homology
 2NOE A;  1WEG A;  1HU0 A;  4EW4 A;  1MPG A;  3CVT A;  1N3A A;  3OH6 A;  1KG2 A;  1XQP A;  3FHF A;  3F0Z A;  2OFI A;  3FSP A;  1P59 A;  3CWU A;  1RRS A;  1KQJ A;  4B21 A;  1YQM A;  1KG7 A;  4EJZ A;  4EW0 A;  2JHJ A;  1ORN A;  3CVS A;  4EJY A;  3IHO A;  1MUN A;  3I0X A;  1EBM A;  3I0W A;  2ABK A;  1P7M A;  4E9F A;  1FN7 A;  1KG4 A;  3CWS A;  3IH7 A;  1PU7 A;  2NOB A;  1KG6 A;  1KG3 A;  2NOH A;  4B23 A;  4E9G A;  1PU6 A;  4EA5 A;  3KNT A;  1LWY A;  4B24 A;  1NKU A;  1DIZ A;  4OFE A;  4AIA A;  1M3Q A;  2NOZ A;  3OGD A;  4AI4 A;  5AN4 A;  1YQL A;  4E9H A;  2NOF A;  1WEI A;  1LWW A;  3KTU A;  5KN8 A;  1N39 A;  3N0U A;  2JHN A;  4E9E A;  4UNF A;  5CHZ A;  1PU8 A;  4EA4 A;  4EVV A;  1MUY A;  4UOB A;  1ORP A;  2YG9 A;  3OH9 A;  1YQR A;  2JG6 A;  2NOL A;  4DK9 A;  5DPK A;  3S6I A;  1XQO A;  2NOI A;  3N5N X;  4HSB A;  3CW7 A;  5KN9 A;  3G0Q A;  2XHI A;  1RRQ A;  1KG5 A;  4B22 A;  4YPR A;  4PII A;  2H56 A;  4OFH A;  1MUD A;  3FHG A;  2I5W A;  1LMZ A;  1M3H A;  4YPH A;  4YOQ A;  1VRL A;  1N3C A;  1NGN A;  1KO9 A;  4OFA A;  1WEF A;  2YG8 A;  1XG7 A;  1LWV A;  3F10 A;  1PVS A;  1KEA A;  2OFK A;  3CWA A;  3D4V A;  3CWT A;  4AI5 A;  1YQK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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