4L8UA

X-ray study of human serum albumin complexed with 9 amino camptothecin
Total Genus 236
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
236
sequence length
583
structure length
583
Chain Sequence
AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Serum albumin
total genus 236
structure length 583
sequence length 583
ec nomenclature
pdb deposition date 2013-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA05
1BKEA 2I30A 5DQFA 2BXOA 4S1YA 2XVUA 5DBYA 2VDBA 4L9QA 5ID9A 2BXIA 4K2CA 4LB2A 4PO0A 2BXMA 5FUOA 4F5SA 3LU6A 4Z69A 4HGKA 3B9MA 4K71A 2BXLA 2VUEA 3V09A 1E7GA 4F5UA 1HK5A 2YDFA 5GHKA 1BM0A 3A73A 2BXDA 1BJ5A 4EMXA 4IW2A 4ZBQA 1E7EA 3JRYA 3UIVA 1O9XA 4L8UA 2XSIA 2XVQA 4G04A 4BKEA 1E7FA 2I2ZA 1LOTA 4J2VA 2BXGA 1J78A 1E7HA 5IIUA 5IIHA 1HK3A 2BXEA 1GNIA 5IFOA 1KXPD 2BXAA 4LUFA 2VUFA 3SQJA 2BXNA 3B9LA 1J7EA 1N5UA 3LU7A 1HA2A 1HK4A 4JK4A 1AO6A 4N0UD 2BXBA 2XVVA 1HK2A 2XW0A 4L9KA 2XW1A 2BXKA 3LU8A 1KW2A 4ZBRA 3V03A 4E99A 4LA0A 2BXHA 5HOZA 1UORA 1HK1A 1GNJA 2BXCA 4OR0A 1E7AA 4F5VA 4F5TA 1H9ZA 4LB9A 2BXFA 2BXQA 3JQZA 1E7IA 3TDLA 4LUHA 5ID7A 2BX8A 4N0FD 4OT2A 5IIXA 1E7CA 3CX9A 1E78A 2BXPA 4HGMB 4G03A 5IJ5A 4IW1A 1MA9A 3V08A 2XVWA 5IJEA 5IJFA 1E7BA 1TF0A
chains in the Genus database with same CATH superfamily
2GUTA 5D7GA 1BKEA 2I30A 5DQFA 2E0XA 2BXOA 4S1YA 2XVUA 5DBYA 3MHHB 2VDBA 4L9QA 5ID9A 1MUSA 2BXIA 4K2CA 4ZBKA 4ZC6A 4LB2A 4PO0A 2BXMA 5FUOA 4F5SA 2QHBA 3LU6A 2EFCA 1KDXA 4Z69A 2DBUA 2NQOA 4HGKA 3SIUB 3B9MA 4K71A 1FOUA 2BXLA 2VUEA 3FNMA 1E7GA 3V09A 3GQXA 2QMCA 3GQUA 4WA6B 1HK5A 2E0YA 4F5UA 2YDFA 3H3AA 1BM0A 5GHKA 3A73A 3FWCC 2DYMA 2V36A 2BXDA 1BJ5A 3VQIA 2Z8KA 4I9OA 3SIVB 4C31B 4EMXA 1NT2B 2EFHA 3W1SA 2JUHA 2LXSA 4IW2A 4ZBQA 1E7EA 3JRYA 3UIVA 3WHQA 1O9XA 4L8UA 2XSIA 2XVQA 4G04A 3MHSB 4OTUA 3WHRA 3NMUA 4BKEA 2QM6A 3KIKA 1E7FA 3G9KD 2AGHB 5B5TA 2I2ZA 4ZUXV 1LOTA 1VZSA 2EFEA 4GDXA 3NVKA 4J2VA 2BXGA 4D7XA 1J78A 1E7HA 2DYOA 4W4UB 5IIUA 5IIHA 1HK3A 2BXEA 1LNSA 1GNIA 2Z8JA 3ECPA 2KBZA 5IFOA 1KXPD 3NVIA 2XMOA 2OZBB 2KWFA 3BPJA 2BXAA 4LUFA 2VUFA 3SQJA 2BXNA 3B9LA 1JNBA 1J7EA 1N5UA 3LU7A 5GIPA 1HA2A 1HK4A 2NNWA 4GG2A 4JK4A 1AO6A 4MBEC 2LXTA 4N0UD 4TQ0A 2BXBA 2CKXA 2XVVA 1HK2A 2LOQA 2Z8IA 2XW0A 4L9KA 4OTTA 4FK5B 2EFDA 3KJLA 1H5WA 2DBWA 2XW1A 2BXKA 2DBXA 1MIWA 3FWBC 1MM8A 3LU8A 4Z9OA 1KW2A 1MUHA 2LQIA 4ZBRA 2DG5A 4M70B 4G01A 3V03A 4E99A 4LA0A 4FIPB 3PLAA 5BPKA 1IJGA 2BXHA 5HOZA 1UORA 1HK1A 4FJCB 1GNJA 2BXCA 4OR0A 1E7AA 3TDLA 1MIYA 4DM0A 4F5VA 4N3ZA 4F5TA 3GA9L 1MIVA 1H9ZA 4LB9A 3NVMA 2BXFA 2BXQA 3JQZA 1E7IA 4TQ1A 1SB0A 4LUHA 2BX8A 2AJEA 2ROHA 4N0FD 4OT2A 4ZCGA 5ID7A 2LQHA 3A75A 5IIXA 1VFIA 5GIOA 1E7CA 1TXUA 4GDLB 4DHXB 3CX9A 4BY9C 1E78A 2BXPA 4HGMB 4G03A 4NAWB 2K0NA 5IJ5A 3H37A 2OT3A 3WHSA 4IW1A 1MA9A 3V08A 2XVWA 3ICXA 4GDKB 5GINA 5IJEA 5IJFA 1E7BA 3M99C 1TF0A
chains in the Genus database with same CATH topology
5D7GA 1BKEA 2I30A 5DQFA 2E0XA 2BXOA 4S1YA 2XVUA 5DBYA 3MHHB 2VDBA 4L9QA 5ID9A 2BXIA 4K2CA 4ZBKA 4ZC6A 4LB2A 4PO0A 2BXMA 5FUOA 4F5SA 2QHBA 3LU6A 2EFCA 4Z69A 2DBUA 2NQOA 4HGKA 3SIUB 3B9MA 4K71A 1FOUA 2BXLA 2VUEA 3FNMA 1E7GA 3V09A 3GQXA 2QMCA 3GQUA 4WA6B 1HK5A 2E0YA 4F5UA 2YDFA 3H3AA 1BM0A 5GHKA 3A73A 3FWCC 2DYMA 2V36A 2BXDA 1BJ5A 3VQIA 2Z8KA 3SIVB 4C31B 4EMXA 1NT2B 2EFHA 3W1SA 2JUHA 4IW2A 4ZBQA 1E7EA 3JRYA 3UIVA 3WHQA 1O9XA 4L8UA 2XSIA 2XVQA 4G04A 3MHSB 4OTUA 3WHRA 3NMUA 4BKEA 2QM6A 3KIKA 1E7FA 3G9KD 5B5TA 2I2ZA 4ZUXV 1LOTA 1VZSA 2EFEA 4GDXA 3NVKA 4J2VA 2BXGA 1J78A 1E7HA 2DYOA 4W4UB 5IIUA 5IIHA 1HK3A 2BXEA 1LNSA 1GNIA 2Z8JA 2KBZA 5IFOA 1KXPD 3NVIA 2XMOA 2OZBB 2BXAA 4LUFA 2VUFA 3SQJA 2BXNA 3B9LA 1JNBA 1J7EA 1N5UA 3LU7A 5GIPA 1HA2A 1HK4A 2NNWA 4GG2A 4JK4A 1AO6A 4MBEC 4TQ0A 4N0UD 2BXBA 2CKXA 2XVVA 1HK2A 2LOQA 2Z8IA 2XW0A 4L9KA 4OTTA 4FK5B 2EFDA 3KJLA 1H5WA 2DBWA 2XW1A 2BXKA 2DBXA 1MIWA 3FWBC 3LU8A 4Z9OA 1KW2A 4ZBRA 2DG5A 4M70B 4G01A 3V03A 4E99A 4LA0A 4FIPB 3PLAA 5BPKA 1IJGA 2BXHA 5HOZA 1UORA 1HK1A 4FJCB 1GNJA 2BXCA 4OR0A 1E7AA 1MIYA 4F5VA 4N3ZA 4F5TA 3GA9L 1MIVA 1H9ZA 4LB9A 3NVMA 2BXFA 2BXQA 3JQZA 1E7IA 4TQ1A 4LUHA 4ZCGA 2BX8A 2AJEA 2ROHA 4N0FD 4OT2A 3TDLA 5ID7A 5IIXA 3A75A 5GIOA 1VFIA 1E7CA 1TXUA 4GDLB 4DHXB 3CX9A 4BY9C 1E78A 2BXPA 4HGMB 4G03A 4NAWB 5IJ5A 3H37A 2OT3A 3WHSA 4IW1A 1MA9A 3V08A 2XVWA 3ICXA 4GDKB 5GINA 5IJEA 5IJFA 1E7BA 3M99C 1TF0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BKE A;  2I30 A;  5DQF A;  2BXO A;  4S1Y A;  2XVU A;  5DBY A;  2VDB A;  4L9Q A;  5ID9 A;  2BXI A;  4K2C A;  4LB2 A;  4PO0 A;  2BXM A;  5FUO A;  4F5S A;  3LU6 A;  4Z69 A;  4HGK A;  3B9M A;  4K71 A;  2BXL A;  2VUE A;  3V09 A;  1E7G A;  4F5U A;  1HK5 A;  2YDF A;  5GHK A;  1BM0 A;  3A73 A;  2BXD A;  1BJ5 A;  4EMX A;  4IW2 A;  4ZBQ A;  1E7E A;  3JRY A;  3UIV A;  1O9X A;  4L8U A;  2XSI A;  2XVQ A;  4G04 A;  4BKE A;  1E7F A;  2I2Z A;  1LOT A;  4J2V A;  2BXG A;  1J78 A;  1E7H A;  5IIU A;  5IIH A;  1HK3 A;  2BXE A;  1GNI A;  5IFO A;  1KXP D;  2BXA A;  4LUF A;  2VUF A;  3SQJ A;  2BXN A;  3B9L A;  1J7E A;  1N5U A;  3LU7 A;  1HA2 A;  1HK4 A;  4JK4 A;  1AO6 A;  4N0U D;  2BXB A;  2XVV A;  1HK2 A;  2XW0 A;  4L9K A;  2XW1 A;  2BXK A;  3LU8 A;  1KW2 A;  4ZBR A;  3V03 A;  4E99 A;  4LA0 A;  2BXH A;  5HOZ A;  1UOR A;  1HK1 A;  1GNJ A;  2BXC A;  4OR0 A;  1E7A A;  4F5V A;  4F5T A;  1H9Z A;  4LB9 A;  2BXF A;  2BXQ A;  3JQZ A;  1E7I A;  3TDL A;  4LUH A;  5ID7 A;  2BX8 A;  4N0F D;  4OT2 A;  5IIX A;  1E7C A;  3CX9 A;  1E78 A;  2BXP A;  4HGM B;  4G03 A;  5IJ5 A;  4IW1 A;  1MA9 A;  3V08 A;  2XVW A;  5IJE A;  5IJF A;  1E7B A;  1TF0 A; 
#chains in the Genus database with same CATH topology
 2GUT A;  5D7G A;  1BKE A;  2I30 A;  5DQF A;  2E0X A;  2BXO A;  4S1Y A;  2XVU A;  5DBY A;  3MHH B;  2VDB A;  4L9Q A;  5ID9 A;  1MUS A;  2BXI A;  4K2C A;  4ZBK A;  4ZC6 A;  4LB2 A;  4PO0 A;  2BXM A;  5FUO A;  4F5S A;  2QHB A;  3LU6 A;  2EFC A;  1KDX A;  4Z69 A;  2DBU A;  2NQO A;  4HGK A;  3SIU B;  3B9M A;  4K71 A;  1FOU A;  2BXL A;  2VUE A;  3FNM A;  1E7G A;  3V09 A;  3GQX A;  2QMC A;  3GQU A;  4WA6 B;  1HK5 A;  2E0Y A;  4F5U A;  2YDF A;  3H3A A;  1BM0 A;  5GHK A;  3A73 A;  3FWC C;  2DYM A;  2V36 A;  2BXD A;  1BJ5 A;  3VQI A;  2Z8K A;  4I9O A;  3SIV B;  4C31 B;  4EMX A;  1NT2 B;  2EFH A;  3W1S A;  2JUH A;  2LXS A;  4IW2 A;  4ZBQ A;  1E7E A;  3JRY A;  3UIV A;  3WHQ A;  1O9X A;  4L8U A;  2XSI A;  2XVQ A;  4G04 A;  3MHS B;  4OTU A;  3WHR A;  3NMU A;  4BKE A;  2QM6 A;  3KIK A;  1E7F A;  3G9K D;  2AGH B;  5B5T A;  2I2Z A;  4ZUX V;  1LOT A;  1VZS A;  2EFE A;  4GDX A;  3NVK A;  4J2V A;  2BXG A;  4D7X A;  1J78 A;  1E7H A;  2DYO A;  4W4U B;  5IIU A;  5IIH A;  1HK3 A;  2BXE A;  1LNS A;  1GNI A;  2Z8J A;  3ECP A;  2KBZ A;  5IFO A;  1KXP D;  3NVI A;  2XMO A;  2OZB B;  2KWF A;  3BPJ A;  2BXA A;  4LUF A;  2VUF A;  3SQJ A;  2BXN A;  3B9L A;  1JNB A;  1J7E A;  1N5U A;  3LU7 A;  5GIP A;  1HA2 A;  1HK4 A;  2NNW A;  4GG2 A;  4JK4 A;  1AO6 A;  4MBE C;  2LXT A;  4N0U D;  4TQ0 A;  2BXB A;  2CKX A;  2XVV A;  1HK2 A;  2LOQ A;  2Z8I A;  2XW0 A;  4L9K A;  4OTT A;  4FK5 B;  2EFD A;  3KJL A;  1H5W A;  2DBW A;  2XW1 A;  2BXK A;  2DBX A;  1MIW A;  3FWB C;  1MM8 A;  3LU8 A;  4Z9O A;  1KW2 A;  1MUH A;  2LQI A;  4ZBR A;  2DG5 A;  4M70 B;  4G01 A;  3V03 A;  4E99 A;  4LA0 A;  4FIP B;  3PLA A;  5BPK A;  1IJG A;  2BXH A;  5HOZ A;  1UOR A;  1HK1 A;  4FJC B;  1GNJ A;  2BXC A;  4OR0 A;  1E7A A;  3TDL A;  1MIY A;  4DM0 A;  4F5V A;  4N3Z A;  4F5T A;  3GA9 L;  1MIV A;  1H9Z A;  4LB9 A;  3NVM A;  2BXF A;  2BXQ A;  3JQZ A;  1E7I A;  4TQ1 A;  1SB0 A;  4LUH A;  2BX8 A;  2AJE A;  2ROH A;  4N0F D;  4OT2 A;  4ZCG A;  5ID7 A;  2LQH A;  3A75 A;  5IIX A;  1VFI A;  5GIO A;  1E7C A;  1TXU A;  4GDL B;  4DHX B;  3CX9 A;  4BY9 C;  1E78 A;  2BXP A;  4HGM B;  4G03 A;  4NAW B;  2K0N A;  5IJ5 A;  3H37 A;  2OT3 A;  3WHS A;  4IW1 A;  1MA9 A;  3V08 A;  2XVW A;  3ICX A;  4GDK B;  5GIN A;  5IJE A;  5IJF A;  1E7B A;  3M99 C;  1TF0 A; 
#chains in the Genus database with same CATH homology
 5D7G A;  1BKE A;  2I30 A;  5DQF A;  2E0X A;  2BXO A;  4S1Y A;  2XVU A;  5DBY A;  3MHH B;  2VDB A;  4L9Q A;  5ID9 A;  2BXI A;  4K2C A;  4ZBK A;  4ZC6 A;  4LB2 A;  4PO0 A;  2BXM A;  5FUO A;  4F5S A;  2QHB A;  3LU6 A;  2EFC A;  4Z69 A;  2DBU A;  2NQO A;  4HGK A;  3SIU B;  3B9M A;  4K71 A;  1FOU A;  2BXL A;  2VUE A;  3FNM A;  1E7G A;  3V09 A;  3GQX A;  2QMC A;  3GQU A;  4WA6 B;  1HK5 A;  2E0Y A;  4F5U A;  2YDF A;  3H3A A;  1BM0 A;  5GHK A;  3A73 A;  3FWC C;  2DYM A;  2V36 A;  2BXD A;  1BJ5 A;  3VQI A;  2Z8K A;  3SIV B;  4C31 B;  4EMX A;  1NT2 B;  2EFH A;  3W1S A;  2JUH A;  4IW2 A;  4ZBQ A;  1E7E A;  3JRY A;  3UIV A;  3WHQ A;  1O9X A;  4L8U A;  2XSI A;  2XVQ A;  4G04 A;  3MHS B;  4OTU A;  3WHR A;  3NMU A;  4BKE A;  2QM6 A;  3KIK A;  1E7F A;  3G9K D;  5B5T A;  2I2Z A;  4ZUX V;  1LOT A;  1VZS A;  2EFE A;  4GDX A;  3NVK A;  4J2V A;  2BXG A;  1J78 A;  1E7H A;  2DYO A;  4W4U B;  5IIU A;  5IIH A;  1HK3 A;  2BXE A;  1LNS A;  1GNI A;  2Z8J A;  2KBZ A;  5IFO A;  1KXP D;  3NVI A;  2XMO A;  2OZB B;  2BXA A;  4LUF A;  2VUF A;  3SQJ A;  2BXN A;  3B9L A;  1JNB A;  1J7E A;  1N5U A;  3LU7 A;  5GIP A;  1HA2 A;  1HK4 A;  2NNW A;  4GG2 A;  4JK4 A;  1AO6 A;  4MBE C;  4TQ0 A;  4N0U D;  2BXB A;  2CKX A;  2XVV A;  1HK2 A;  2LOQ A;  2Z8I A;  2XW0 A;  4L9K A;  4OTT A;  4FK5 B;  2EFD A;  3KJL A;  1H5W A;  2DBW A;  2XW1 A;  2BXK A;  2DBX A;  1MIW A;  3FWB C;  3LU8 A;  4Z9O A;  1KW2 A;  4ZBR A;  2DG5 A;  4M70 B;  4G01 A;  3V03 A;  4E99 A;  4LA0 A;  4FIP B;  3PLA A;  5BPK A;  1IJG A;  2BXH A;  5HOZ A;  1UOR A;  1HK1 A;  4FJC B;  1GNJ A;  2BXC A;  4OR0 A;  1E7A A;  1MIY A;  4F5V A;  4N3Z A;  4F5T A;  3GA9 L;  1MIV A;  1H9Z A;  4LB9 A;  3NVM A;  2BXF A;  2BXQ A;  3JQZ A;  1E7I A;  4TQ1 A;  4LUH A;  4ZCG A;  2BX8 A;  2AJE A;  2ROH A;  4N0F D;  4OT2 A;  3TDL A;  5ID7 A;  5IIX A;  3A75 A;  5GIO A;  1VFI A;  1E7C A;  1TXU A;  4GDL B;  4DHX B;  3CX9 A;  4BY9 C;  1E78 A;  2BXP A;  4HGM B;  4G03 A;  4NAW B;  5IJ5 A;  3H37 A;  2OT3 A;  3WHS A;  4IW1 A;  1MA9 A;  3V08 A;  2XVW A;  3ICX A;  4GDK B;  5GIN A;  5IJE A;  5IJF A;  1E7B A;  3M99 C;  1TF0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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