4L8UA

X-ray study of human serum albumin complexed with 9 amino camptothecin
Total Genus 236
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
236
sequence length
583
structure length
583
Chain Sequence
AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Serum albumin
total genus 236
structure length 583
sequence length 583
ec nomenclature
pdb deposition date 2013-06-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l8uA05
2I30A 4IW1A 1KW2A 2BXIA 2BXNA 4N0FD 3V03A 5IIXA 2BX8A 4S1YA 1J78A 4LB2A 4Z69A 1E7GA 1GNJA 4L8UA 1E78A 1BKEA 2BXQA 3B9LA 5DQFA 3SQJA 1HK3A 4L9KA 1LOTA 2VDBA 2VUFA 2BXCA 3A73A 3JRYA 1E7BA 2BXGA 5ID9A 1HK1A 3CX9A 4K71A 4EMXA 1O9XA 2XVVA 5IJEA 5IIHA 1UORA 4L9QA 4ZBRA 1E7EA 4BKEA 3V08A 4IW2A 4HGMB 2XW1A 3LU6A 4F5SA 5GHKA 4OT2A 1AO6A 2XVWA 2BXPA 5IJFA 3UIVA 2XSIA 1KXPD 1E7CA 5ID7A 5IIUA 1E7FA 2XW0A 4G04A 5IJ5A 4ZBQA 2BXMA 2BXBA 4N0UD 2XVUA 2BXLA 4LA0A 4J2VA 1HA2A 2BXEA 4F5TA 2BXFA 1H9ZA 2XVQA 5IFOA 4F5UA 1MA9A 5DBYA 3B9MA 1J7EA 4HGKA 1HK2A 4K2CA 1N5UA 1GNIA 3TDLA 3LU8A 1TF0A 4LB9A 2BXDA 3LU7A 2BXOA 4OR0A 4LUHA 1HK5A 5HOZA 1BJ5A 2BXHA 5FUOA 2BXAA 2BXKA 4G03A 1BM0A 3V09A 1E7HA 2YDFA 1E7AA 4F5VA 4JK4A 4PO0A 3JQZA 1E7IA 1HK4A 4LUFA 4E99A 2I2ZA 2VUEA
chains in the Genus database with same CATH superfamily
2I30A 3ICXA 3SIUB 4IW1A 1KW2A 1MIVA 2BXIA 2BXNA 4N0FD 3KJLA 4FK5B 3V03A 2OZBB 2KBZA 5IIXA 2QHBA 2BX8A 4S1YA 1J78A 3FWBC 2EFHA 4LB2A 4Z69A 1E7GA 1GNJA 4L8UA 1E78A 4D7XA 4FJCB 1BKEA 2BXQA 2QM6A 3B9LA 5DQFA 3SQJA 3H3AA 1HK3A 2AGHB 4TQ0A 3H37A 3WHRA 2NQOA 4L9KA 1LOTA 2VDBA 2VUFA 2BXCA 3BPJA 1VZSA 3A73A 3JRYA 4G01A 3G9KD 2DBWA 1E7BA 3MHHB 4ZUXV 2BXGA 5ID9A 1HK1A 3CX9A 4K71A 4EMXA 4I9OA 1O9XA 2V36A 2XVVA 5IJEA 5IIHA 2DYOA 5D7GA 3WHSA 4C31B 1UORA 4L9QA 4ZBRA 2EFCA 3KIKA 1E7EA 4BKEA 1VFIA 3V08A 1SB0A 2AJEA 4IW2A 4GDLB 2EFDA 3WHQA 4HGMB 2XW1A 2KWFA 1JNBA 4ZBKA 2Z8JA 3LU6A 1TXUA 2K0NA 1H5WA 2LXSA 4F5SA 5GIPA 5GHKA 4OT2A 3VQIA 1AO6A 2XVWA 4FIPB 2BXPA 2DBXA 4WA6B 1IJGA 3NVMA 5IJFA 1MIWA 3UIVA 2XSIA 3SIVB 1KXPD 1KDXA 1E7CA 2ROHA 2Z8IA 4GDXA 4N3ZA 5ID7A 5IIUA 1E7FA 2XW0A 2LXTA 4G04A 5IJ5A 4DM0A 4ZBQA 2BXMA 2BXBA 4OTTA 4N0UD 2XVUA 2BXLA 4LA0A 1MUHA 3PLAA 4J2VA 1HA2A 2XMOA 2BXEA 4F5TA 2BXFA 1MIYA 1H9ZA 1MM8A 2XVQA 5IFOA 4ZC6A 4F5UA 2GUTA 4ZCGA 1MA9A 2QMCA 3FNMA 4M70B 5DBYA 5GINA 3B9MA 4W4UB 1J7EA 4HGKA 1HK2A 4Z9OA 4K2CA 3FWCC 1N5UA 1GNIA 3TDLA 3LU8A 3M99C 5BPKA 1TF0A 4LB9A 2BXDA 4OTUA 1NT2B 3LU7A 2BXOA 2E0XA 2Z8KA 4OR0A 2OT3A 2JUHA 4LUHA 2LOQA 1FOUA 1HK5A 2NNWA 4BY9C 3NVKA 5HOZA 4DHXB 1BJ5A 3GQXA 2BXHA 5FUOA 2DYMA 2BXAA 2BXKA 4G03A 1BM0A 2DBUA 3NMUA 5B5TA 3GA9L 1E7HA 3V09A 1MUSA 2YDFA 2E0YA 4NAWB 1LNSA 4GG2A 3NVIA 1E7AA 3MHSB 3GQUA 2DG5A 2EFEA 5GIOA 2LQIA 3ECPA 4F5VA 4JK4A 4PO0A 3JQZA 4TQ1A 1E7IA 1HK4A 4GDKB 4LUFA 4E99A 2I2ZA 3A75A 4MBEC 3W1SA 2CKXA 2LQHA 2VUEA
chains in the Genus database with same CATH topology
2I30A 3ICXA 3SIUB 4IW1A 1KW2A 1MIVA 2BXIA 2BXNA 4N0FD 3KJLA 4FK5B 3V03A 2OZBB 2KBZA 5IIXA 2QHBA 2BX8A 4S1YA 1J78A 3FWBC 2EFHA 4LB2A 4Z69A 1E7GA 1GNJA 4L8UA 1E78A 4FJCB 1BKEA 2BXQA 2QM6A 3B9LA 5DQFA 3SQJA 3H3AA 1HK3A 4TQ0A 3H37A 3WHRA 2NQOA 4L9KA 1LOTA 2VDBA 2VUFA 2BXCA 1VZSA 3A73A 3JRYA 4G01A 3G9KD 2DBWA 1E7BA 3MHHB 4ZUXV 2BXGA 5ID9A 1HK1A 3CX9A 4K71A 4EMXA 1O9XA 2V36A 2XVVA 5IJEA 5IIHA 2DYOA 5D7GA 3WHSA 4C31B 1UORA 4L9QA 4ZBRA 2EFCA 3KIKA 1E7EA 4BKEA 1VFIA 3V08A 2AJEA 4IW2A 4GDLB 2EFDA 3WHQA 4HGMB 2XW1A 1JNBA 4ZBKA 2Z8JA 3LU6A 1TXUA 4F5SA 1H5WA 5GIPA 5GHKA 4OT2A 3VQIA 1AO6A 2XVWA 4FIPB 2BXPA 2DBXA 4WA6B 1IJGA 3NVMA 5IJFA 1MIWA 3UIVA 2XSIA 3SIVB 1KXPD 1E7CA 2ROHA 2Z8IA 4GDXA 4N3ZA 5ID7A 5IIUA 1E7FA 2XW0A 4G04A 5IJ5A 4ZBQA 2BXMA 2BXBA 4OTTA 4N0UD 2XVUA 2BXLA 4LA0A 3PLAA 4J2VA 1HA2A 2XMOA 2BXEA 4F5TA 2BXFA 1MIYA 1H9ZA 2XVQA 5IFOA 4ZC6A 4F5UA 4ZCGA 1MA9A 2QMCA 3FNMA 4M70B 5DBYA 5GINA 3B9MA 4W4UB 1J7EA 4HGKA 1HK2A 4Z9OA 4K2CA 3FWCC 1N5UA 1GNIA 3TDLA 3LU8A 3M99C 5BPKA 1TF0A 4LB9A 2BXDA 4OTUA 1NT2B 3LU7A 2BXOA 2E0XA 2Z8KA 4OR0A 2OT3A 2JUHA 4LUHA 2LOQA 1FOUA 1HK5A 2NNWA 4BY9C 3NVKA 5HOZA 4DHXB 1BJ5A 3GQXA 2BXHA 5FUOA 2DYMA 2BXAA 2BXKA 4G03A 1BM0A 2DBUA 3NMUA 5B5TA 3GA9L 1E7HA 3V09A 2YDFA 2E0YA 4NAWB 1LNSA 4GG2A 3NVIA 1E7AA 3MHSB 3GQUA 2DG5A 2EFEA 5GIOA 4F5VA 4JK4A 4PO0A 3JQZA 4TQ1A 1E7IA 1HK4A 4GDKB 4LUFA 4E99A 2I2ZA 3A75A 4MBEC 3W1SA 2CKXA 2VUEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I30 A;  4IW1 A;  1KW2 A;  2BXI A;  2BXN A;  4N0F D;  3V03 A;  5IIX A;  2BX8 A;  4S1Y A;  1J78 A;  4LB2 A;  4Z69 A;  1E7G A;  1GNJ A;  4L8U A;  1E78 A;  1BKE A;  2BXQ A;  3B9L A;  5DQF A;  3SQJ A;  1HK3 A;  4L9K A;  1LOT A;  2VDB A;  2VUF A;  2BXC A;  3A73 A;  3JRY A;  1E7B A;  2BXG A;  5ID9 A;  1HK1 A;  3CX9 A;  4K71 A;  4EMX A;  1O9X A;  2XVV A;  5IJE A;  5IIH A;  1UOR A;  4L9Q A;  4ZBR A;  1E7E A;  4BKE A;  3V08 A;  4IW2 A;  4HGM B;  2XW1 A;  3LU6 A;  4F5S A;  5GHK A;  4OT2 A;  1AO6 A;  2XVW A;  2BXP A;  5IJF A;  3UIV A;  2XSI A;  1KXP D;  1E7C A;  5ID7 A;  5IIU A;  1E7F A;  2XW0 A;  4G04 A;  5IJ5 A;  4ZBQ A;  2BXM A;  2BXB A;  4N0U D;  2XVU A;  2BXL A;  4LA0 A;  4J2V A;  1HA2 A;  2BXE A;  4F5T A;  2BXF A;  1H9Z A;  2XVQ A;  5IFO A;  4F5U A;  1MA9 A;  5DBY A;  3B9M A;  1J7E A;  4HGK A;  1HK2 A;  4K2C A;  1N5U A;  1GNI A;  3TDL A;  3LU8 A;  1TF0 A;  4LB9 A;  2BXD A;  3LU7 A;  2BXO A;  4OR0 A;  4LUH A;  1HK5 A;  5HOZ A;  1BJ5 A;  2BXH A;  5FUO A;  2BXA A;  2BXK A;  4G03 A;  1BM0 A;  3V09 A;  1E7H A;  2YDF A;  1E7A A;  4F5V A;  4JK4 A;  4PO0 A;  3JQZ A;  1E7I A;  1HK4 A;  4LUF A;  4E99 A;  2I2Z A;  2VUE A; 
#chains in the Genus database with same CATH topology
 2I30 A;  3ICX A;  3SIU B;  4IW1 A;  1KW2 A;  1MIV A;  2BXI A;  2BXN A;  4N0F D;  3KJL A;  4FK5 B;  3V03 A;  2OZB B;  2KBZ A;  5IIX A;  2QHB A;  2BX8 A;  4S1Y A;  1J78 A;  3FWB C;  2EFH A;  4LB2 A;  4Z69 A;  1E7G A;  1GNJ A;  4L8U A;  1E78 A;  4D7X A;  4FJC B;  1BKE A;  2BXQ A;  2QM6 A;  3B9L A;  5DQF A;  3SQJ A;  3H3A A;  1HK3 A;  2AGH B;  4TQ0 A;  3H37 A;  3WHR A;  2NQO A;  4L9K A;  1LOT A;  2VDB A;  2VUF A;  2BXC A;  3BPJ A;  1VZS A;  3A73 A;  3JRY A;  4G01 A;  3G9K D;  2DBW A;  1E7B A;  3MHH B;  4ZUX V;  2BXG A;  5ID9 A;  1HK1 A;  3CX9 A;  4K71 A;  4EMX A;  4I9O A;  1O9X A;  2V36 A;  2XVV A;  5IJE A;  5IIH A;  2DYO A;  5D7G A;  3WHS A;  4C31 B;  1UOR A;  4L9Q A;  4ZBR A;  2EFC A;  3KIK A;  1E7E A;  4BKE A;  1VFI A;  3V08 A;  1SB0 A;  2AJE A;  4IW2 A;  4GDL B;  2EFD A;  3WHQ A;  4HGM B;  2XW1 A;  2KWF A;  1JNB A;  4ZBK A;  2Z8J A;  3LU6 A;  1TXU A;  2K0N A;  1H5W A;  2LXS A;  4F5S A;  5GIP A;  5GHK A;  4OT2 A;  3VQI A;  1AO6 A;  2XVW A;  4FIP B;  2BXP A;  2DBX A;  4WA6 B;  1IJG A;  3NVM A;  5IJF A;  1MIW A;  3UIV A;  2XSI A;  3SIV B;  1KXP D;  1KDX A;  1E7C A;  2ROH A;  2Z8I A;  4GDX A;  4N3Z A;  5ID7 A;  5IIU A;  1E7F A;  2XW0 A;  2LXT A;  4G04 A;  5IJ5 A;  4DM0 A;  4ZBQ A;  2BXM A;  2BXB A;  4OTT A;  4N0U D;  2XVU A;  2BXL A;  4LA0 A;  1MUH A;  3PLA A;  4J2V A;  1HA2 A;  2XMO A;  2BXE A;  4F5T A;  2BXF A;  1MIY A;  1H9Z A;  1MM8 A;  2XVQ A;  5IFO A;  4ZC6 A;  4F5U A;  2GUT A;  4ZCG A;  1MA9 A;  2QMC A;  3FNM A;  4M70 B;  5DBY A;  5GIN A;  3B9M A;  4W4U B;  1J7E A;  4HGK A;  1HK2 A;  4Z9O A;  4K2C A;  3FWC C;  1N5U A;  1GNI A;  3TDL A;  3LU8 A;  3M99 C;  5BPK A;  1TF0 A;  4LB9 A;  2BXD A;  4OTU A;  1NT2 B;  3LU7 A;  2BXO A;  2E0X A;  2Z8K A;  4OR0 A;  2OT3 A;  2JUH A;  4LUH A;  2LOQ A;  1FOU A;  1HK5 A;  2NNW A;  4BY9 C;  3NVK A;  5HOZ A;  4DHX B;  1BJ5 A;  3GQX A;  2BXH A;  5FUO A;  2DYM A;  2BXA A;  2BXK A;  4G03 A;  1BM0 A;  2DBU A;  3NMU A;  5B5T A;  3GA9 L;  1E7H A;  3V09 A;  1MUS A;  2YDF A;  2E0Y A;  4NAW B;  1LNS A;  4GG2 A;  3NVI A;  1E7A A;  3MHS B;  3GQU A;  2DG5 A;  2EFE A;  5GIO A;  2LQI A;  3ECP A;  4F5V A;  4JK4 A;  4PO0 A;  3JQZ A;  4TQ1 A;  1E7I A;  1HK4 A;  4GDK B;  4LUF A;  4E99 A;  2I2Z A;  3A75 A;  4MBE C;  3W1S A;  2CKX A;  2LQH A;  2VUE A; 
#chains in the Genus database with same CATH homology
 2I30 A;  3ICX A;  3SIU B;  4IW1 A;  1KW2 A;  1MIV A;  2BXI A;  2BXN A;  4N0F D;  3KJL A;  4FK5 B;  3V03 A;  2OZB B;  2KBZ A;  5IIX A;  2QHB A;  2BX8 A;  4S1Y A;  1J78 A;  3FWB C;  2EFH A;  4LB2 A;  4Z69 A;  1E7G A;  1GNJ A;  4L8U A;  1E78 A;  4FJC B;  1BKE A;  2BXQ A;  2QM6 A;  3B9L A;  5DQF A;  3SQJ A;  3H3A A;  1HK3 A;  4TQ0 A;  3H37 A;  3WHR A;  2NQO A;  4L9K A;  1LOT A;  2VDB A;  2VUF A;  2BXC A;  1VZS A;  3A73 A;  3JRY A;  4G01 A;  3G9K D;  2DBW A;  1E7B A;  3MHH B;  4ZUX V;  2BXG A;  5ID9 A;  1HK1 A;  3CX9 A;  4K71 A;  4EMX A;  1O9X A;  2V36 A;  2XVV A;  5IJE A;  5IIH A;  2DYO A;  5D7G A;  3WHS A;  4C31 B;  1UOR A;  4L9Q A;  4ZBR A;  2EFC A;  3KIK A;  1E7E A;  4BKE A;  1VFI A;  3V08 A;  2AJE A;  4IW2 A;  4GDL B;  2EFD A;  3WHQ A;  4HGM B;  2XW1 A;  1JNB A;  4ZBK A;  2Z8J A;  3LU6 A;  1TXU A;  4F5S A;  1H5W A;  5GIP A;  5GHK A;  4OT2 A;  3VQI A;  1AO6 A;  2XVW A;  4FIP B;  2BXP A;  2DBX A;  4WA6 B;  1IJG A;  3NVM A;  5IJF A;  1MIW A;  3UIV A;  2XSI A;  3SIV B;  1KXP D;  1E7C A;  2ROH A;  2Z8I A;  4GDX A;  4N3Z A;  5ID7 A;  5IIU A;  1E7F A;  2XW0 A;  4G04 A;  5IJ5 A;  4ZBQ A;  2BXM A;  2BXB A;  4OTT A;  4N0U D;  2XVU A;  2BXL A;  4LA0 A;  3PLA A;  4J2V A;  1HA2 A;  2XMO A;  2BXE A;  4F5T A;  2BXF A;  1MIY A;  1H9Z A;  2XVQ A;  5IFO A;  4ZC6 A;  4F5U A;  4ZCG A;  1MA9 A;  2QMC A;  3FNM A;  4M70 B;  5DBY A;  5GIN A;  3B9M A;  4W4U B;  1J7E A;  4HGK A;  1HK2 A;  4Z9O A;  4K2C A;  3FWC C;  1N5U A;  1GNI A;  3TDL A;  3LU8 A;  3M99 C;  5BPK A;  1TF0 A;  4LB9 A;  2BXD A;  4OTU A;  1NT2 B;  3LU7 A;  2BXO A;  2E0X A;  2Z8K A;  4OR0 A;  2OT3 A;  2JUH A;  4LUH A;  2LOQ A;  1FOU A;  1HK5 A;  2NNW A;  4BY9 C;  3NVK A;  5HOZ A;  4DHX B;  1BJ5 A;  3GQX A;  2BXH A;  5FUO A;  2DYM A;  2BXA A;  2BXK A;  4G03 A;  1BM0 A;  2DBU A;  3NMU A;  5B5T A;  3GA9 L;  1E7H A;  3V09 A;  2YDF A;  2E0Y A;  4NAW B;  1LNS A;  4GG2 A;  3NVI A;  1E7A A;  3MHS B;  3GQU A;  2DG5 A;  2EFE A;  5GIO A;  4F5V A;  4JK4 A;  4PO0 A;  3JQZ A;  4TQ1 A;  1E7I A;  1HK4 A;  4GDK B;  4LUF A;  4E99 A;  2I2Z A;  3A75 A;  4MBE C;  3W1S A;  2CKX A;  2VUE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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