4L9KA

X-ray study of human serum albumin complexed with camptothecin
Total Genus 223
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords SERUM ALBUMIN
total genus 223
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA05
1BM0A 3B9MA 1HK2A 4OT2A 3JRYA 2VUFA 3SQJA 4LA0A 2VDBA 1HK1A 1KXPD 3CX9A 1E7EA 4HGMB 2BXGA 2I30A 2YDFA 4L9QA 1AO6A 4K71A 1E7AA 5IJ5A 2BXOA 3LU6A 2BXFA 2XVUA 5IJEA 2I2ZA 3V09A 3LU7A 3V08A 5IIUA 1HA2A 2BXEA 1J7EA 3V03A 4S1YA 2BXDA 4L9KA 1E7FA 2BXQA 5IIHA 2XVWA 2BXMA 4J2VA 5DQFA 2VUEA 5IJFA 1E7IA 4L8UA 1E7BA 4JK4A 4ZBQA 1O9XA 2BXIA 4BKEA 4LUFA 3LU8A 1E78A 2BXCA 2XW1A 2BXAA 2BX8A 1MA9A 1LOTA 2BXPA 2XVVA 3UIVA 4OR0A 4F5TA 4G03A 1E7CA 1H9ZA 1GNIA 2XW0A 1HK3A 5IIXA 1J78A 1TF0A 1E7HA 1UORA 4LB2A 3TDLA 4Z69A 3JQZA 4IW1A 5DBYA 5IFOA 5ID9A 2BXNA 1GNJA 4G04A 1HK5A 1BJ5A 3B9LA 2BXBA 4PO0A 2XVQA 4HGKA 3A73A 4F5SA 4LB9A 5HOZA 1BKEA 4F5UA 2BXKA 5GHKA 4ZBRA 1N5UA 4K2CA 4EMXA 5FUOA 4N0FD 2XSIA 1E7GA 1KW2A 4IW2A 4N0UD 5ID7A 1HK4A 4E99A 4F5VA 4LUHA 2BXLA 2BXHA
chains in the Genus database with same CATH superfamily
1BM0A 2DBUA 3B9MA 4N3ZA 1HK2A 4OT2A 2Z8KA 3JRYA 2V36A 2VUFA 4DM0A 3SQJA 4LA0A 2VDBA 3SIVB 4LUHA 1HK1A 4OTTA 2LXTA 1MUSA 1KXPD 3MHHB 3CX9A 1E7EA 4HGMB 3W1SA 5BPKA 2BXGA 2E0YA 3NVMA 3VQIA 2Z8JA 2Z8IA 1FOUA 2I30A 2YDFA 3KJLA 4L9QA 1AO6A 4K71A 3ECPA 4W4UB 4GDLB 3M99C 1MIYA 1E7AA 2EFHA 3GA9L 4Z9OA 5IJ5A 2DBXA 2BXOA 4ZBKA 3FWBC 3LU6A 2BXFA 2EFCA 1MIWA 2OT3A 1TXUA 2XVUA 5IJEA 2OZBB 2I2ZA 3V09A 3LU7A 2CKXA 3V08A 4MBEC 5IIUA 2DYOA 2QHBA 2QM6A 4FJCB 1HA2A 2BXEA 1J7EA 3V03A 4S1YA 1IJGA 2BXDA 4L9KA 3KIKA 1E7FA 2BXQA 4TQ1A 3FNMA 5IIHA 2XVWA 4C31B 1VFIA 2BXMA 5GINA 4D7XA 4FK5B 2DG5A 2DYMA 4J2VA 2VUEA 5DQFA 5IJFA 1E7IA 4L8UA 3ICXA 4GG2A 1E7BA 4JK4A 4ZBQA 2KBZA 1O9XA 2BXIA 4BKEA 4LUFA 1LNSA 3LU8A 5B5TA 2JUHA 1E78A 2NQOA 2BXCA 2XW1A 5D7GA 2AJEA 2BXAA 4M70B 2BX8A 3A75A 3NMUA 2NNWA 4GDKB 1MA9A 1LOTA 2BXPA 3NVKA 3WHSA 2XVVA 3UIVA 4OR0A 4F5TA 3H37A 3SIUB 1SB0A 4G03A 1KDXA 1E7CA 1H9ZA 1GNIA 2XW0A 1HK3A 4NAWB 3GQUA 1J78A 5IIXA 1TF0A 4G01A 3PLAA 1E7HA 1JNBA 2LXSA 1UORA 2E0XA 4LB2A 3GQXA 3TDLA 2LQHA 1NT2B 4Z69A 2DBWA 3JQZA 1H5WA 3G9KD 4IW1A 5DBYA 2EFDA 5IFOA 3WHRA 5ID9A 2GUTA 2BXNA 3H3AA 1GNJA 1MUHA 4G04A 1HK5A 4BY9C 1BJ5A 4DHXB 4ZUXV 3B9LA 5GIOA 2BXBA 3FWCC 4FIPB 4PO0A 4ZCGA 2XVQA 4HGKA 3A73A 4F5SA 4LB9A 5GIPA 5HOZA 2LQIA 1BKEA 4F5UA 4I9OA 2BXKA 5GHKA 2KWFA 2ROHA 4ZBRA 4TQ0A 1N5UA 4K2CA 4EMXA 1MIVA 5FUOA 3NVIA 3BPJA 4N0FD 4ZC6A 1VZSA 4OTUA 3MHSB 4WA6B 2XSIA 1E7GA 1KW2A 4IW2A 4N0UD 5ID7A 2QMCA 1MM8A 2XMOA 1HK4A 4E99A 4F5VA 2AGHB 2K0NA 2BXLA 2BXHA 4GDXA 3WHQA 2EFEA 2LOQA
chains in the Genus database with same CATH topology
1BM0A 2DBUA 3B9MA 4N3ZA 1HK2A 4OT2A 2Z8KA 3JRYA 2V36A 2VUFA 3SQJA 4LA0A 2VDBA 3SIVB 1HK1A 4OTTA 1KXPD 3MHHB 3CX9A 1E7EA 4HGMB 3W1SA 5BPKA 2BXGA 2E0YA 3NVMA 3VQIA 2Z8JA 2Z8IA 1FOUA 2I30A 2YDFA 3KJLA 4L9QA 1AO6A 4K71A 4W4UB 4GDLB 3M99C 1MIYA 1E7AA 2EFHA 3GA9L 4Z9OA 5IJ5A 2DBXA 2BXOA 4ZBKA 3FWBC 3LU6A 2BXFA 2EFCA 1MIWA 2OT3A 1TXUA 2XVUA 5IJEA 2OZBB 2I2ZA 3V09A 3LU7A 2CKXA 3V08A 4MBEC 5IIUA 2DYOA 2QHBA 2QM6A 4FJCB 1HA2A 2BXEA 1J7EA 3V03A 4S1YA 1IJGA 2BXDA 4L9KA 3KIKA 1E7FA 2BXQA 4TQ1A 3FNMA 5IIHA 2XVWA 4C31B 1VFIA 2BXMA 5GINA 4FK5B 2DG5A 2DYMA 4J2VA 2VUEA 5DQFA 5IJFA 1E7IA 4L8UA 3ICXA 4GG2A 1E7BA 4JK4A 4ZBQA 2KBZA 1O9XA 2BXIA 4BKEA 4LUFA 1LNSA 3LU8A 5B5TA 2JUHA 1E78A 2NQOA 2BXCA 2XW1A 5D7GA 2AJEA 2BXAA 4M70B 2BX8A 3A75A 3NMUA 2NNWA 4GDKB 1MA9A 1LOTA 2BXPA 3NVKA 3WHSA 2XVVA 3UIVA 4OR0A 4F5TA 3H37A 3SIUB 4G03A 1E7CA 1H9ZA 1GNIA 2XW0A 1HK3A 4NAWB 3GQUA 1J78A 5IIXA 1TF0A 4G01A 3PLAA 1E7HA 1JNBA 1UORA 2E0XA 4LB2A 3GQXA 3TDLA 1NT2B 4Z69A 2DBWA 3JQZA 1H5WA 3G9KD 4IW1A 5DBYA 2EFDA 5IFOA 3WHRA 5ID9A 2BXNA 3H3AA 1GNJA 4G04A 1HK5A 4BY9C 1BJ5A 4DHXB 4ZUXV 3B9LA 5GIOA 2BXBA 3FWCC 4FIPB 4PO0A 4ZCGA 2XVQA 4HGKA 3A73A 4F5SA 4LB9A 5GIPA 5HOZA 1BKEA 4F5UA 2BXKA 5GHKA 2ROHA 4ZBRA 4TQ0A 1N5UA 4K2CA 4EMXA 1MIVA 5FUOA 3NVIA 4N0FD 4ZC6A 1VZSA 4OTUA 3MHSB 4WA6B 2XSIA 1E7GA 1KW2A 4IW2A 4N0UD 5ID7A 2QMCA 2XMOA 1HK4A 4E99A 4F5VA 4LUHA 2BXLA 2BXHA 4GDXA 3WHQA 2EFEA 2LOQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BM0 A;  3B9M A;  1HK2 A;  4OT2 A;  3JRY A;  2VUF A;  3SQJ A;  4LA0 A;  2VDB A;  1HK1 A;  1KXP D;  3CX9 A;  1E7E A;  4HGM B;  2BXG A;  2I30 A;  2YDF A;  4L9Q A;  1AO6 A;  4K71 A;  1E7A A;  5IJ5 A;  2BXO A;  3LU6 A;  2BXF A;  2XVU A;  5IJE A;  2I2Z A;  3V09 A;  3LU7 A;  3V08 A;  5IIU A;  1HA2 A;  2BXE A;  1J7E A;  3V03 A;  4S1Y A;  2BXD A;  4L9K A;  1E7F A;  2BXQ A;  5IIH A;  2XVW A;  2BXM A;  4J2V A;  5DQF A;  2VUE A;  5IJF A;  1E7I A;  4L8U A;  1E7B A;  4JK4 A;  4ZBQ A;  1O9X A;  2BXI A;  4BKE A;  4LUF A;  3LU8 A;  1E78 A;  2BXC A;  2XW1 A;  2BXA A;  2BX8 A;  1MA9 A;  1LOT A;  2BXP A;  2XVV A;  3UIV A;  4OR0 A;  4F5T A;  4G03 A;  1E7C A;  1H9Z A;  1GNI A;  2XW0 A;  1HK3 A;  5IIX A;  1J78 A;  1TF0 A;  1E7H A;  1UOR A;  4LB2 A;  3TDL A;  4Z69 A;  3JQZ A;  4IW1 A;  5DBY A;  5IFO A;  5ID9 A;  2BXN A;  1GNJ A;  4G04 A;  1HK5 A;  1BJ5 A;  3B9L A;  2BXB A;  4PO0 A;  2XVQ A;  4HGK A;  3A73 A;  4F5S A;  4LB9 A;  5HOZ A;  1BKE A;  4F5U A;  2BXK A;  5GHK A;  4ZBR A;  1N5U A;  4K2C A;  4EMX A;  5FUO A;  4N0F D;  2XSI A;  1E7G A;  1KW2 A;  4IW2 A;  4N0U D;  5ID7 A;  1HK4 A;  4E99 A;  4F5V A;  4LUH A;  2BXL A;  2BXH A; 
#chains in the Genus database with same CATH topology
 1BM0 A;  2DBU A;  3B9M A;  4N3Z A;  1HK2 A;  4OT2 A;  2Z8K A;  3JRY A;  2V36 A;  2VUF A;  4DM0 A;  3SQJ A;  4LA0 A;  2VDB A;  3SIV B;  4LUH A;  1HK1 A;  4OTT A;  2LXT A;  1MUS A;  1KXP D;  3MHH B;  3CX9 A;  1E7E A;  4HGM B;  3W1S A;  5BPK A;  2BXG A;  2E0Y A;  3NVM A;  3VQI A;  2Z8J A;  2Z8I A;  1FOU A;  2I30 A;  2YDF A;  3KJL A;  4L9Q A;  1AO6 A;  4K71 A;  3ECP A;  4W4U B;  4GDL B;  3M99 C;  1MIY A;  1E7A A;  2EFH A;  3GA9 L;  4Z9O A;  5IJ5 A;  2DBX A;  2BXO A;  4ZBK A;  3FWB C;  3LU6 A;  2BXF A;  2EFC A;  1MIW A;  2OT3 A;  1TXU A;  2XVU A;  5IJE A;  2OZB B;  2I2Z A;  3V09 A;  3LU7 A;  2CKX A;  3V08 A;  4MBE C;  5IIU A;  2DYO A;  2QHB A;  2QM6 A;  4FJC B;  1HA2 A;  2BXE A;  1J7E A;  3V03 A;  4S1Y A;  1IJG A;  2BXD A;  4L9K A;  3KIK A;  1E7F A;  2BXQ A;  4TQ1 A;  3FNM A;  5IIH A;  2XVW A;  4C31 B;  1VFI A;  2BXM A;  5GIN A;  4D7X A;  4FK5 B;  2DG5 A;  2DYM A;  4J2V A;  2VUE A;  5DQF A;  5IJF A;  1E7I A;  4L8U A;  3ICX A;  4GG2 A;  1E7B A;  4JK4 A;  4ZBQ A;  2KBZ A;  1O9X A;  2BXI A;  4BKE A;  4LUF A;  1LNS A;  3LU8 A;  5B5T A;  2JUH A;  1E78 A;  2NQO A;  2BXC A;  2XW1 A;  5D7G A;  2AJE A;  2BXA A;  4M70 B;  2BX8 A;  3A75 A;  3NMU A;  2NNW A;  4GDK B;  1MA9 A;  1LOT A;  2BXP A;  3NVK A;  3WHS A;  2XVV A;  3UIV A;  4OR0 A;  4F5T A;  3H37 A;  3SIU B;  1SB0 A;  4G03 A;  1KDX A;  1E7C A;  1H9Z A;  1GNI A;  2XW0 A;  1HK3 A;  4NAW B;  3GQU A;  1J78 A;  5IIX A;  1TF0 A;  4G01 A;  3PLA A;  1E7H A;  1JNB A;  2LXS A;  1UOR A;  2E0X A;  4LB2 A;  3GQX A;  3TDL A;  2LQH A;  1NT2 B;  4Z69 A;  2DBW A;  3JQZ A;  1H5W A;  3G9K D;  4IW1 A;  5DBY A;  2EFD A;  5IFO A;  3WHR A;  5ID9 A;  2GUT A;  2BXN A;  3H3A A;  1GNJ A;  1MUH A;  4G04 A;  1HK5 A;  4BY9 C;  1BJ5 A;  4DHX B;  4ZUX V;  3B9L A;  5GIO A;  2BXB A;  3FWC C;  4FIP B;  4PO0 A;  4ZCG A;  2XVQ A;  4HGK A;  3A73 A;  4F5S A;  4LB9 A;  5GIP A;  5HOZ A;  2LQI A;  1BKE A;  4F5U A;  4I9O A;  2BXK A;  5GHK A;  2KWF A;  2ROH A;  4ZBR A;  4TQ0 A;  1N5U A;  4K2C A;  4EMX A;  1MIV A;  5FUO A;  3NVI A;  3BPJ A;  4N0F D;  4ZC6 A;  1VZS A;  4OTU A;  3MHS B;  4WA6 B;  2XSI A;  1E7G A;  1KW2 A;  4IW2 A;  4N0U D;  5ID7 A;  2QMC A;  1MM8 A;  2XMO A;  1HK4 A;  4E99 A;  4F5V A;  2AGH B;  2K0N A;  2BXL A;  2BXH A;  4GDX A;  3WHQ A;  2EFE A;  2LOQ A; 
#chains in the Genus database with same CATH homology
 1BM0 A;  2DBU A;  3B9M A;  4N3Z A;  1HK2 A;  4OT2 A;  2Z8K A;  3JRY A;  2V36 A;  2VUF A;  3SQJ A;  4LA0 A;  2VDB A;  3SIV B;  1HK1 A;  4OTT A;  1KXP D;  3MHH B;  3CX9 A;  1E7E A;  4HGM B;  3W1S A;  5BPK A;  2BXG A;  2E0Y A;  3NVM A;  3VQI A;  2Z8J A;  2Z8I A;  1FOU A;  2I30 A;  2YDF A;  3KJL A;  4L9Q A;  1AO6 A;  4K71 A;  4W4U B;  4GDL B;  3M99 C;  1MIY A;  1E7A A;  2EFH A;  3GA9 L;  4Z9O A;  5IJ5 A;  2DBX A;  2BXO A;  4ZBK A;  3FWB C;  3LU6 A;  2BXF A;  2EFC A;  1MIW A;  2OT3 A;  1TXU A;  2XVU A;  5IJE A;  2OZB B;  2I2Z A;  3V09 A;  3LU7 A;  2CKX A;  3V08 A;  4MBE C;  5IIU A;  2DYO A;  2QHB A;  2QM6 A;  4FJC B;  1HA2 A;  2BXE A;  1J7E A;  3V03 A;  4S1Y A;  1IJG A;  2BXD A;  4L9K A;  3KIK A;  1E7F A;  2BXQ A;  4TQ1 A;  3FNM A;  5IIH A;  2XVW A;  4C31 B;  1VFI A;  2BXM A;  5GIN A;  4FK5 B;  2DG5 A;  2DYM A;  4J2V A;  2VUE A;  5DQF A;  5IJF A;  1E7I A;  4L8U A;  3ICX A;  4GG2 A;  1E7B A;  4JK4 A;  4ZBQ A;  2KBZ A;  1O9X A;  2BXI A;  4BKE A;  4LUF A;  1LNS A;  3LU8 A;  5B5T A;  2JUH A;  1E78 A;  2NQO A;  2BXC A;  2XW1 A;  5D7G A;  2AJE A;  2BXA A;  4M70 B;  2BX8 A;  3A75 A;  3NMU A;  2NNW A;  4GDK B;  1MA9 A;  1LOT A;  2BXP A;  3NVK A;  3WHS A;  2XVV A;  3UIV A;  4OR0 A;  4F5T A;  3H37 A;  3SIU B;  4G03 A;  1E7C A;  1H9Z A;  1GNI A;  2XW0 A;  1HK3 A;  4NAW B;  3GQU A;  1J78 A;  5IIX A;  1TF0 A;  4G01 A;  3PLA A;  1E7H A;  1JNB A;  1UOR A;  2E0X A;  4LB2 A;  3GQX A;  3TDL A;  1NT2 B;  4Z69 A;  2DBW A;  3JQZ A;  1H5W A;  3G9K D;  4IW1 A;  5DBY A;  2EFD A;  5IFO A;  3WHR A;  5ID9 A;  2BXN A;  3H3A A;  1GNJ A;  4G04 A;  1HK5 A;  4BY9 C;  1BJ5 A;  4DHX B;  4ZUX V;  3B9L A;  5GIO A;  2BXB A;  3FWC C;  4FIP B;  4PO0 A;  4ZCG A;  2XVQ A;  4HGK A;  3A73 A;  4F5S A;  4LB9 A;  5GIP A;  5HOZ A;  1BKE A;  4F5U A;  2BXK A;  5GHK A;  2ROH A;  4ZBR A;  4TQ0 A;  1N5U A;  4K2C A;  4EMX A;  1MIV A;  5FUO A;  3NVI A;  4N0F D;  4ZC6 A;  1VZS A;  4OTU A;  3MHS B;  4WA6 B;  2XSI A;  1E7G A;  1KW2 A;  4IW2 A;  4N0U D;  5ID7 A;  2QMC A;  2XMO A;  1HK4 A;  4E99 A;  4F5V A;  4LUH A;  2BXL A;  2BXH A;  4GDX A;  3WHQ A;  2EFE A;  2LOQ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...