4OFAA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of MBD4 bound to G:T mispair DNA
rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 50
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofaA00
1KG6A 4EVVA 2YG8A 2OFKA 3I0XA 4B23A 1KG4A 2I5WA 3KNTA 4OFHA 3FHGA 1KEAA 3F0ZA 3OH6A 4E9FA 4EJYA 2JG6A 1KQJA 4EW4A 3CVSA 1N3AA 1NKUA 2NOLA 3N0UA 1YQLA 4OFEA 1N3CA 4PIIA 4YPRA 3FHFA 1YQRA 3CWTA 1HU0A 5KN8A 5DPKA 1DIZA 2JHJA 1VRLA 2NOZA 3CWAA 5AN4A 2YG9A 1MUDA 4DK9A 4B22A 1NGNA 1PU6A 1P59A 3CW7A 3F10A 4AI4A 1RRSA 3D4VA 3KTUA 3OGDA 2H56A 4EJZA 4E9EA 4OFAA 2XHIA 2NOHA 1KG2A 4UOBA 1M3HA 1EBMA 1MUYA 4EA4A 1ORPA 4YOQA 2NOBA 2NOIA 4UNFA 1WEFA 4AIAA 1WEIA 2OFIA 1KO9A 1MUNA 1PVSA 5CHZA 1MPGA 2NOFA 4B21A 1P7MA 1KG5A 1LMZA 3CWSA 3OH9A 3FSPA 3CWUA 4E9GA 1N39A 1LWWA 1LWYA 1YQKA 1PU8A 3N5NX 1M3QA 3IH7A 1WEGA 3G0QA 1XQOA 4HSBA 4E9HA 4AI5A 1ORNA 3I0WA 3S6IA 1XQPA 1PU7A 4EA5A 4YPHA 1KG7A 1XG7A 5KN9A 1LWVA 2JHNA 2ABKA 3CVTA 4B24A 2NOEA 3IHOA 1YQMA 1RRQA 1FN7A 4EW0A 1KG3A
chains in the Genus database with same CATH superfamily
1KG6A 3OYLA 4EVVA 5FRMA 2YG8A 2OFKA 3I0XA 4B23A 4E7JA 1KG4A 2I5WA 2W04A 3KNTA 4OFHA 3FHGA 1KEAA 3F0ZA 3OH6A 4E9FA 4EJYA 2JG6A 1KQJA 4BACA 4EW4A 3CVSA 1N3AA 1NKUA 4BDZA 3N0UA 1YQLA 3VW4A 2NOLA 3L2RA 4OFEA 3OS0A 1N3CA 4E7LA 4PIIA 4YPRA 3FHFA 1YQRA 3CWTA 1HU0A 3OYGA 5KN8A 5DPKA 1DIZA 3OS1A 3S3MA 2JHJA 1VRLA 2NOZA 3CWAA 5AN4A 2YG9A 3L2QA 1MUDA 3S3OA 4BE1A 4DK9A 4B22A 4ZTFA 1NGNA 1PU6A 3R2XC 1P59A 3OY9A 3OYAA 3CW7A 3F10A 4AI4A 3OS2A 3OYFA 1RRSA 3D4VA 3KTUA 3OGDA 3L2UA 4BE2A 2W03A 3OYMA 5FROA 3LCNA 2H56A 4EJZA 4E9EA 4OFAA 3OYEA 4E7IA 2XHIA 2NOHA 1KG2A 4UOBA 1M3HA 1EBMA 1MUYA 3OYHA 4EA4A 1ORPA 4YOQA 2NOBA 2NOIA 2V75A 4UNFA 1WEFA 4AIAA 1WEIA 2OFIA 4ZTJA 1KO9A 1MUNA 1PVSA 5CHZA 3S3NA 1MPGA 2NOFA 5FRNA 2JPSA 4B21A 1P7MA 1KG5A 4BE0A 3OYNA 3L2WA 1LMZA 3NNQA 3OYKA 3CWSA 3OH9A 3FSPA 3CWUA 4E9GA 4E7KA 1N39A 1LWWA 1LWYA 1YQKA 1PU8A 3N5NX 1M3QA 4IKFA 3IH7A 1WEGA 3G0QA 1XQOA 3OYDA 4HSBA 4E9HA 4AI5A 1ORNA 3I0WA 4NZGA 3S6IA 1U84A 3OYCA 1XQPA 1PU7A 4EA5A 4YPHA 1KG7A 3OYIA 3OYJA 1XG7A 3OYBA 5KN9A 1LWVA 2JHNA 2ABKA 3CVTA 4B24A 2NOEA 3IHOA 1YQMA 1RRQA 1FN7A 4BDYA 4E7HA 4EW0A 1KG3A 3L2VA
chains in the Genus database with same CATH topology
1KG6A 4EVVA 2YG8A 2OFKA 3I0XA 4B23A 1KG4A 2I5WA 3KNTA 4OFHA 3FHGA 1KEAA 3F0ZA 3OH6A 4E9FA 4EJYA 2JG6A 1KQJA 4EW4A 3CVSA 1N3AA 1NKUA 2NOLA 3N0UA 1YQLA 4OFEA 1N3CA 4PIIA 4YPRA 3FHFA 1YQRA 3CWTA 1HU0A 5KN8A 5DPKA 1DIZA 2JHJA 1VRLA 2NOZA 3CWAA 5AN4A 2YG9A 1MUDA 4DK9A 4B22A 1NGNA 1PU6A 1P59A 3CW7A 3F10A 4AI4A 1RRSA 3D4VA 3KTUA 3OGDA 2H56A 4EJZA 4E9EA 4OFAA 2XHIA 2NOHA 1KG2A 4UOBA 1M3HA 1EBMA 1MUYA 4EA4A 1ORPA 4YOQA 2NOBA 2NOIA 4UNFA 1WEFA 4AIAA 1WEIA 2OFIA 1KO9A 1MUNA 1PVSA 5CHZA 1MPGA 2NOFA 4B21A 1P7MA 1KG5A 1LMZA 3CWSA 3OH9A 3FSPA 3CWUA 4E9GA 1N39A 1LWWA 1LWYA 1YQKA 1PU8A 3N5NX 1M3QA 3IH7A 1WEGA 3G0QA 1XQOA 4HSBA 4E9HA 4AI5A 1ORNA 3I0WA 3S6IA 1XQPA 1PU7A 4EA5A 4YPHA 1KG7A 1XG7A 5KN9A 1LWVA 2JHNA 2ABKA 3CVTA 4B24A 2NOEA 3IHOA 1YQMA 1RRQA 1FN7A 4EW0A 1KG3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KG6 A;  4EVV A;  2YG8 A;  2OFK A;  3I0X A;  4B23 A;  1KG4 A;  2I5W A;  3KNT A;  4OFH A;  3FHG A;  1KEA A;  3F0Z A;  3OH6 A;  4E9F A;  4EJY A;  2JG6 A;  1KQJ A;  4EW4 A;  3CVS A;  1N3A A;  1NKU A;  2NOL A;  3N0U A;  1YQL A;  4OFE A;  1N3C A;  4PII A;  4YPR A;  3FHF A;  1YQR A;  3CWT A;  1HU0 A;  5KN8 A;  5DPK A;  1DIZ A;  2JHJ A;  1VRL A;  2NOZ A;  3CWA A;  5AN4 A;  2YG9 A;  1MUD A;  4DK9 A;  4B22 A;  1NGN A;  1PU6 A;  1P59 A;  3CW7 A;  3F10 A;  4AI4 A;  1RRS A;  3D4V A;  3KTU A;  3OGD A;  2H56 A;  4EJZ A;  4E9E A;  4OFA A;  2XHI A;  2NOH A;  1KG2 A;  4UOB A;  1M3H A;  1EBM A;  1MUY A;  4EA4 A;  1ORP A;  4YOQ A;  2NOB A;  2NOI A;  4UNF A;  1WEF A;  4AIA A;  1WEI A;  2OFI A;  1KO9 A;  1MUN A;  1PVS A;  5CHZ A;  1MPG A;  2NOF A;  4B21 A;  1P7M A;  1KG5 A;  1LMZ A;  3CWS A;  3OH9 A;  3FSP A;  3CWU A;  4E9G A;  1N39 A;  1LWW A;  1LWY A;  1YQK A;  1PU8 A;  3N5N X;  1M3Q A;  3IH7 A;  1WEG A;  3G0Q A;  1XQO A;  4HSB A;  4E9H A;  4AI5 A;  1ORN A;  3I0W A;  3S6I A;  1XQP A;  1PU7 A;  4EA5 A;  4YPH A;  1KG7 A;  1XG7 A;  5KN9 A;  1LWV A;  2JHN A;  2ABK A;  3CVT A;  4B24 A;  2NOE A;  3IHO A;  1YQM A;  1RRQ A;  1FN7 A;  4EW0 A;  1KG3 A; 
#chains in the Genus database with same CATH topology
 1KG6 A;  3OYL A;  4EVV A;  5FRM A;  2YG8 A;  2OFK A;  3I0X A;  4B23 A;  4E7J A;  1KG4 A;  2I5W A;  2W04 A;  3KNT A;  4OFH A;  3FHG A;  1KEA A;  3F0Z A;  3OH6 A;  4E9F A;  4EJY A;  2JG6 A;  1KQJ A;  4BAC A;  4EW4 A;  3CVS A;  1N3A A;  1NKU A;  4BDZ A;  3N0U A;  1YQL A;  3VW4 A;  2NOL A;  3L2R A;  4OFE A;  3OS0 A;  1N3C A;  4E7L A;  4PII A;  4YPR A;  3FHF A;  1YQR A;  3CWT A;  1HU0 A;  3OYG A;  5KN8 A;  5DPK A;  1DIZ A;  3OS1 A;  3S3M A;  2JHJ A;  1VRL A;  2NOZ A;  3CWA A;  5AN4 A;  2YG9 A;  3L2Q A;  1MUD A;  3S3O A;  4BE1 A;  4DK9 A;  4B22 A;  4ZTF A;  1NGN A;  1PU6 A;  3R2X C;  1P59 A;  3OY9 A;  3OYA A;  3CW7 A;  3F10 A;  4AI4 A;  3OS2 A;  3OYF A;  1RRS A;  3D4V A;  3KTU A;  3OGD A;  3L2U A;  4BE2 A;  2W03 A;  3OYM A;  5FRO A;  3LCN A;  2H56 A;  4EJZ A;  4E9E A;  4OFA A;  3OYE A;  4E7I A;  2XHI A;  2NOH A;  1KG2 A;  4UOB A;  1M3H A;  1EBM A;  1MUY A;  3OYH A;  4EA4 A;  1ORP A;  4YOQ A;  2NOB A;  2NOI A;  2V75 A;  4UNF A;  1WEF A;  4AIA A;  1WEI A;  2OFI A;  4ZTJ A;  1KO9 A;  1MUN A;  1PVS A;  5CHZ A;  3S3N A;  1MPG A;  2NOF A;  5FRN A;  2JPS A;  4B21 A;  1P7M A;  1KG5 A;  4BE0 A;  3OYN A;  3L2W A;  1LMZ A;  3NNQ A;  3OYK A;  3CWS A;  3OH9 A;  3FSP A;  3CWU A;  4E9G A;  4E7K A;  1N39 A;  1LWW A;  1LWY A;  1YQK A;  1PU8 A;  3N5N X;  1M3Q A;  4IKF A;  3IH7 A;  1WEG A;  3G0Q A;  1XQO A;  3OYD A;  4HSB A;  4E9H A;  4AI5 A;  1ORN A;  3I0W A;  4NZG A;  3S6I A;  1U84 A;  3OYC A;  1XQP A;  1PU7 A;  4EA5 A;  4YPH A;  1KG7 A;  3OYI A;  3OYJ A;  1XG7 A;  3OYB A;  5KN9 A;  1LWV A;  2JHN A;  2ABK A;  3CVT A;  4B24 A;  2NOE A;  3IHO A;  1YQM A;  1RRQ A;  1FN7 A;  4BDY A;  4E7H A;  4EW0 A;  1KG3 A;  3L2V A; 
#chains in the Genus database with same CATH homology
 1KG6 A;  4EVV A;  2YG8 A;  2OFK A;  3I0X A;  4B23 A;  1KG4 A;  2I5W A;  3KNT A;  4OFH A;  3FHG A;  1KEA A;  3F0Z A;  3OH6 A;  4E9F A;  4EJY A;  2JG6 A;  1KQJ A;  4EW4 A;  3CVS A;  1N3A A;  1NKU A;  2NOL A;  3N0U A;  1YQL A;  4OFE A;  1N3C A;  4PII A;  4YPR A;  3FHF A;  1YQR A;  3CWT A;  1HU0 A;  5KN8 A;  5DPK A;  1DIZ A;  2JHJ A;  1VRL A;  2NOZ A;  3CWA A;  5AN4 A;  2YG9 A;  1MUD A;  4DK9 A;  4B22 A;  1NGN A;  1PU6 A;  1P59 A;  3CW7 A;  3F10 A;  4AI4 A;  1RRS A;  3D4V A;  3KTU A;  3OGD A;  2H56 A;  4EJZ A;  4E9E A;  4OFA A;  2XHI A;  2NOH A;  1KG2 A;  4UOB A;  1M3H A;  1EBM A;  1MUY A;  4EA4 A;  1ORP A;  4YOQ A;  2NOB A;  2NOI A;  4UNF A;  1WEF A;  4AIA A;  1WEI A;  2OFI A;  1KO9 A;  1MUN A;  1PVS A;  5CHZ A;  1MPG A;  2NOF A;  4B21 A;  1P7M A;  1KG5 A;  1LMZ A;  3CWS A;  3OH9 A;  3FSP A;  3CWU A;  4E9G A;  1N39 A;  1LWW A;  1LWY A;  1YQK A;  1PU8 A;  3N5N X;  1M3Q A;  3IH7 A;  1WEG A;  3G0Q A;  1XQO A;  4HSB A;  4E9H A;  4AI5 A;  1ORN A;  3I0W A;  3S6I A;  1XQP A;  1PU7 A;  4EA5 A;  4YPH A;  1KG7 A;  1XG7 A;  5KN9 A;  1LWV A;  2JHN A;  2ABK A;  3CVT A;  4B24 A;  2NOE A;  3IHO A;  1YQM A;  1RRQ A;  1FN7 A;  4EW0 A;  1KG3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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