4OFAA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
142
structure length
142
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLSL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
source organism Homo sapiens
publication title Structure of MBD4 bound to G:T mispair DNA
rcsb
molecule keywords Methyl-CpG-binding domain protein 4
total genus 50
structure length 142
sequence length 142
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofaA00
2I5WA 1M3HA 3S6IA 4B24A 1RRQA 1ORNA 1KG5A 2YG8A 1XQOA 5CHZA 4OFEA 5KN8A 1WEGA 1KG3A 1PU8A 3OH6A 3F10A 3FHGA 1P7MA 3OGDA 4EA5A 1N3AA 1N3CA 1LWVA 3CVSA 4B23A 1KG6A 4EW0A 1LWWA 3N5NX 3KNTA 2OFIA 4YPRA 1HU0A 4OFHA 4PIIA 1MPGA 4UNFA 1KEAA 3N0UA 3OH9A 1NGNA 1MUYA 3D4VA 3CWTA 3CW7A 1WEIA 1DIZA 4E9HA 5DPKA 4EJZA 2XHIA 3F0ZA 4YOQA 2ABKA 5KN9A 3CWUA 1KG2A 1WEFA 3IHOA 1KG7A 4OFAA 1VRLA 1FN7A 4B21A 1MUDA 3IH7A 4B22A 1LWYA 1PVSA 1NKUA 3CWAA 2YG9A 1P59A 3KTUA 4EW4A 2JG6A 3FSPA 1XG7A 4EA4A 4EVVA 1KO9A 4E9GA 4YPHA 2JHNA 1KG4A 1YQMA 1ORPA 1LMZA 3G0QA 2JHJA 4AIAA 5AN4A 1MUNA 1KQJA 1M3QA 2NOZA 4AI5A 4E9FA 1YQLA 1PU6A 1EBMA 2NOEA 1XQPA 4DK9A 2NOLA 1PU7A 2NOIA 3I0WA 1YQRA 2OFKA 1YQKA 2NOFA 2H56A 4AI4A 3I0XA 1RRSA 4HSBA 4EJYA 1N39A 2NOBA 3CWSA 3CVTA 2NOHA 4E9EA 4UOBA 3FHFA
chains in the Genus database with same CATH superfamily
2I5WA 1M3HA 3S6IA 4ZTFA 3R2XC 4B24A 1RRQA 1ORNA 1KG5A 4BE0A 2YG8A 1XQOA 5CHZA 4OFEA 5KN8A 1WEGA 1KG3A 1PU8A 3OH6A 5FRMA 3F10A 3FHGA 1P7MA 3OYCA 3OGDA 4EA5A 3OYDA 1N3AA 1N3CA 4ZTJA 1LWVA 3CVSA 4B23A 1KG6A 3L2WA 4EW0A 1LWWA 3N5NX 3KNTA 3OYKA 2OFIA 4YPRA 1HU0A 3L2RA 4OFHA 4PIIA 1MPGA 3NNQA 4UNFA 3L2UA 2JPSA 3OYGA 1KEAA 3N0UA 3OH9A 1NGNA 1MUYA 3OYIA 3D4VA 3CWTA 3CW7A 1WEIA 1DIZA 4E7HA 3OS1A 4E9HA 5DPKA 4EJZA 2XHIA 3F0ZA 3OY9A 4YOQA 2W04A 2ABKA 4BDZA 5KN9A 3CWUA 5FRNA 3OYJA 5FROA 1KG2A 1WEFA 3IHOA 1KG7A 4OFAA 3L2VA 1VRLA 4BACA 4BE1A 1FN7A 4B21A 1MUDA 3IH7A 4E7IA 3L2QA 3LCNA 4B22A 1LWYA 1PVSA 1U84A 1NKUA 3CWAA 4E7JA 3OS0A 3OYEA 2YG9A 1P59A 3OYAA 3KTUA 4EW4A 2JG6A 3FSPA 1XG7A 4EA4A 4EVVA 4IKFA 1KO9A 4E9GA 4YPHA 2JHNA 1KG4A 3OYNA 1YQMA 3OYHA 3OYLA 1ORPA 1LMZA 3G0QA 2JHJA 4NZGA 4AIAA 5AN4A 1MUNA 1KQJA 1M3QA 2NOZA 4AI5A 4E9FA 4E7KA 1YQLA 1PU6A 3S3NA 2W03A 1EBMA 2NOEA 3OYMA 3VW4A 3S3MA 1XQPA 3OYBA 4DK9A 2NOLA 1PU7A 3S3OA 2NOIA 3I0WA 1YQRA 2V75A 2OFKA 1YQKA 3OS2A 2H56A 4AI4A 3I0XA 4E7LA 1RRSA 2NOFA 4HSBA 4EJYA 4BDYA 1N39A 3OYFA 2NOBA 3CWSA 3CVTA 2NOHA 4BE2A 4E9EA 4UOBA 3FHFA
chains in the Genus database with same CATH topology
2I5WA 1M3HA 3S6IA 4B24A 1RRQA 1ORNA 1KG5A 2YG8A 1XQOA 5CHZA 4OFEA 5KN8A 1WEGA 1KG3A 1PU8A 3OH6A 3F10A 3FHGA 1P7MA 3OGDA 4EA5A 1N3AA 1N3CA 1LWVA 3CVSA 4B23A 1KG6A 4EW0A 1LWWA 3N5NX 3KNTA 2OFIA 4YPRA 1HU0A 4OFHA 4PIIA 1MPGA 4UNFA 1KEAA 3N0UA 3OH9A 1NGNA 1MUYA 3D4VA 3CWTA 3CW7A 1WEIA 1DIZA 4E9HA 5DPKA 4EJZA 2XHIA 3F0ZA 4YOQA 2ABKA 5KN9A 3CWUA 1KG2A 1WEFA 3IHOA 1KG7A 4OFAA 1VRLA 1FN7A 4B21A 1MUDA 3IH7A 4B22A 1LWYA 1PVSA 1NKUA 3CWAA 2YG9A 1P59A 3KTUA 4EW4A 2JG6A 3FSPA 1XG7A 4EA4A 4EVVA 1KO9A 4E9GA 4YPHA 2JHNA 1KG4A 1YQMA 1ORPA 1LMZA 3G0QA 2JHJA 4AIAA 5AN4A 1MUNA 1KQJA 1M3QA 2NOZA 4AI5A 4E9FA 1YQLA 1PU6A 1EBMA 2NOEA 1XQPA 4DK9A 2NOLA 1PU7A 2NOIA 3I0WA 1YQRA 2OFKA 1YQKA 2NOFA 2H56A 4AI4A 3I0XA 1RRSA 4HSBA 4EJYA 1N39A 2NOBA 3CWSA 3CVTA 2NOHA 4E9EA 4UOBA 3FHFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I5W A;  1M3H A;  3S6I A;  4B24 A;  1RRQ A;  1ORN A;  1KG5 A;  2YG8 A;  1XQO A;  5CHZ A;  4OFE A;  5KN8 A;  1WEG A;  1KG3 A;  1PU8 A;  3OH6 A;  3F10 A;  3FHG A;  1P7M A;  3OGD A;  4EA5 A;  1N3A A;  1N3C A;  1LWV A;  3CVS A;  4B23 A;  1KG6 A;  4EW0 A;  1LWW A;  3N5N X;  3KNT A;  2OFI A;  4YPR A;  1HU0 A;  4OFH A;  4PII A;  1MPG A;  4UNF A;  1KEA A;  3N0U A;  3OH9 A;  1NGN A;  1MUY A;  3D4V A;  3CWT A;  3CW7 A;  1WEI A;  1DIZ A;  4E9H A;  5DPK A;  4EJZ A;  2XHI A;  3F0Z A;  4YOQ A;  2ABK A;  5KN9 A;  3CWU A;  1KG2 A;  1WEF A;  3IHO A;  1KG7 A;  4OFA A;  1VRL A;  1FN7 A;  4B21 A;  1MUD A;  3IH7 A;  4B22 A;  1LWY A;  1PVS A;  1NKU A;  3CWA A;  2YG9 A;  1P59 A;  3KTU A;  4EW4 A;  2JG6 A;  3FSP A;  1XG7 A;  4EA4 A;  4EVV A;  1KO9 A;  4E9G A;  4YPH A;  2JHN A;  1KG4 A;  1YQM A;  1ORP A;  1LMZ A;  3G0Q A;  2JHJ A;  4AIA A;  5AN4 A;  1MUN A;  1KQJ A;  1M3Q A;  2NOZ A;  4AI5 A;  4E9F A;  1YQL A;  1PU6 A;  1EBM A;  2NOE A;  1XQP A;  4DK9 A;  2NOL A;  1PU7 A;  2NOI A;  3I0W A;  1YQR A;  2OFK A;  1YQK A;  2NOF A;  2H56 A;  4AI4 A;  3I0X A;  1RRS A;  4HSB A;  4EJY A;  1N39 A;  2NOB A;  3CWS A;  3CVT A;  2NOH A;  4E9E A;  4UOB A;  3FHF A; 
#chains in the Genus database with same CATH topology
 2I5W A;  1M3H A;  3S6I A;  4ZTF A;  3R2X C;  4B24 A;  1RRQ A;  1ORN A;  1KG5 A;  4BE0 A;  2YG8 A;  1XQO A;  5CHZ A;  4OFE A;  5KN8 A;  1WEG A;  1KG3 A;  1PU8 A;  3OH6 A;  5FRM A;  3F10 A;  3FHG A;  1P7M A;  3OYC A;  3OGD A;  4EA5 A;  3OYD A;  1N3A A;  1N3C A;  4ZTJ A;  1LWV A;  3CVS A;  4B23 A;  1KG6 A;  3L2W A;  4EW0 A;  1LWW A;  3N5N X;  3KNT A;  3OYK A;  2OFI A;  4YPR A;  1HU0 A;  3L2R A;  4OFH A;  4PII A;  1MPG A;  3NNQ A;  4UNF A;  3L2U A;  2JPS A;  3OYG A;  1KEA A;  3N0U A;  3OH9 A;  1NGN A;  1MUY A;  3OYI A;  3D4V A;  3CWT A;  3CW7 A;  1WEI A;  1DIZ A;  4E7H A;  3OS1 A;  4E9H A;  5DPK A;  4EJZ A;  2XHI A;  3F0Z A;  3OY9 A;  4YOQ A;  2W04 A;  2ABK A;  4BDZ A;  5KN9 A;  3CWU A;  5FRN A;  3OYJ A;  5FRO A;  1KG2 A;  1WEF A;  3IHO A;  1KG7 A;  4OFA A;  3L2V A;  1VRL A;  4BAC A;  4BE1 A;  1FN7 A;  4B21 A;  1MUD A;  3IH7 A;  4E7I A;  3L2Q A;  3LCN A;  4B22 A;  1LWY A;  1PVS A;  1U84 A;  1NKU A;  3CWA A;  4E7J A;  3OS0 A;  3OYE A;  2YG9 A;  1P59 A;  3OYA A;  3KTU A;  4EW4 A;  2JG6 A;  3FSP A;  1XG7 A;  4EA4 A;  4EVV A;  4IKF A;  1KO9 A;  4E9G A;  4YPH A;  2JHN A;  1KG4 A;  3OYN A;  1YQM A;  3OYH A;  3OYL A;  1ORP A;  1LMZ A;  3G0Q A;  2JHJ A;  4NZG A;  4AIA A;  5AN4 A;  1MUN A;  1KQJ A;  1M3Q A;  2NOZ A;  4AI5 A;  4E9F A;  4E7K A;  1YQL A;  1PU6 A;  3S3N A;  2W03 A;  1EBM A;  2NOE A;  3OYM A;  3VW4 A;  3S3M A;  1XQP A;  3OYB A;  4DK9 A;  2NOL A;  1PU7 A;  3S3O A;  2NOI A;  3I0W A;  1YQR A;  2V75 A;  2OFK A;  1YQK A;  3OS2 A;  2H56 A;  4AI4 A;  3I0X A;  4E7L A;  1RRS A;  2NOF A;  4HSB A;  4EJY A;  4BDY A;  1N39 A;  3OYF A;  2NOB A;  3CWS A;  3CVT A;  2NOH A;  4BE2 A;  4E9E A;  4UOB A;  3FHF A; 
#chains in the Genus database with same CATH homology
 2I5W A;  1M3H A;  3S6I A;  4B24 A;  1RRQ A;  1ORN A;  1KG5 A;  2YG8 A;  1XQO A;  5CHZ A;  4OFE A;  5KN8 A;  1WEG A;  1KG3 A;  1PU8 A;  3OH6 A;  3F10 A;  3FHG A;  1P7M A;  3OGD A;  4EA5 A;  1N3A A;  1N3C A;  1LWV A;  3CVS A;  4B23 A;  1KG6 A;  4EW0 A;  1LWW A;  3N5N X;  3KNT A;  2OFI A;  4YPR A;  1HU0 A;  4OFH A;  4PII A;  1MPG A;  4UNF A;  1KEA A;  3N0U A;  3OH9 A;  1NGN A;  1MUY A;  3D4V A;  3CWT A;  3CW7 A;  1WEI A;  1DIZ A;  4E9H A;  5DPK A;  4EJZ A;  2XHI A;  3F0Z A;  4YOQ A;  2ABK A;  5KN9 A;  3CWU A;  1KG2 A;  1WEF A;  3IHO A;  1KG7 A;  4OFA A;  1VRL A;  1FN7 A;  4B21 A;  1MUD A;  3IH7 A;  4B22 A;  1LWY A;  1PVS A;  1NKU A;  3CWA A;  2YG9 A;  1P59 A;  3KTU A;  4EW4 A;  2JG6 A;  3FSP A;  1XG7 A;  4EA4 A;  4EVV A;  1KO9 A;  4E9G A;  4YPH A;  2JHN A;  1KG4 A;  1YQM A;  1ORP A;  1LMZ A;  3G0Q A;  2JHJ A;  4AIA A;  5AN4 A;  1MUN A;  1KQJ A;  1M3Q A;  2NOZ A;  4AI5 A;  4E9F A;  1YQL A;  1PU6 A;  1EBM A;  2NOE A;  1XQP A;  4DK9 A;  2NOL A;  1PU7 A;  2NOI A;  3I0W A;  1YQR A;  2OFK A;  1YQK A;  2NOF A;  2H56 A;  4AI4 A;  3I0X A;  1RRS A;  4HSB A;  4EJY A;  1N39 A;  2NOB A;  3CWS A;  3CVT A;  2NOH A;  4E9E A;  4UOB A;  3FHF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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