4OFHA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
141
structure length
141
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase/dna
source organism Homo sapiens
publication title Structure of MBD4 bound to O6MeG:T mispair DNA
rcsb
molecule keywords Methyl-CpG-binding domain protein 4
total genus 51
structure length 141
sequence length 141
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofhA00
1N39A 1KQJA 3F10A 5KN9A 1FN7A 2H56A 4B21A 1WEIA 1DIZA 2JHJA 4B22A 3IH7A 3KTUA 4E9FA 2YG9A 1YQLA 3CVSA 3OGDA 4E9GA 4AIAA 1KG5A 2NOEA 3D4VA 1HU0A 1ORPA 2NOLA 4PIIA 1KG3A 5AN4A 1P7MA 1ORNA 1LWWA 3CW7A 4OFHA 1RRQA 1KG4A 1WEFA 4EVVA 1LWYA 2I5WA 4YPRA 3KNTA 1EBMA 4EA5A 2JHNA 1XQPA 4AI5A 4HSBA 5KN8A 1MUDA 3FHFA 1NGNA 4B23A 1M3HA 1LMZA 2NOFA 1KG6A 3CWUA 2NOHA 1MUNA 2XHIA 1PU6A 1MPGA 1XG7A 3IHOA 3N0UA 1RRSA 3OH6A 3FSPA 4E9HA 1KO9A 1PU7A 4UOBA 4B24A 4YPHA 4EW4A 1KG7A 2OFKA 1PU8A 3CWAA 4UNFA 1NKUA 1LWVA 1PVSA 1N3AA 4OFEA 2NOIA 5DPKA 1P59A 3G0QA 2NOZA 1M3QA 1YQMA 3S6IA 3CVTA 4EJYA 4EA4A 3I0XA 2OFIA 1KG2A 2JG6A 3FHGA 4YOQA 1YQRA 4EW0A 3CWTA 1XQOA 1VRLA 2NOBA 1MUYA 1N3CA 2ABKA 3I0WA 1WEGA 1KEAA 1YQKA 3CWSA 2YG8A 4DK9A 4EJZA 3N5NX 4AI4A 5CHZA 4OFAA 3F0ZA 3OH9A 4E9EA
chains in the Genus database with same CATH superfamily
1N39A 1KQJA 3NNQA 3F10A 5KN9A 1FN7A 2H56A 4B21A 4BACA 1WEIA 3S3NA 1DIZA 2JHJA 4B22A 3IH7A 3KTUA 4E9FA 2YG9A 1YQLA 3CVSA 3OGDA 3OYLA 4E9GA 4AIAA 1KG5A 2NOEA 3D4VA 4ZTJA 4E7KA 1HU0A 3R2XC 1ORPA 2NOLA 4PIIA 1KG3A 4E7HA 5AN4A 1P7MA 1ORNA 1LWWA 3CW7A 4OFHA 3OYFA 1RRQA 3OYIA 5FROA 1KG4A 1WEFA 4EVVA 4BE2A 1LWYA 2I5WA 4YPRA 2W04A 2V75A 3KNTA 3OS2A 3OYNA 1EBMA 3OS1A 4EA5A 2JHNA 3OY9A 1XQPA 4AI5A 4HSBA 4E7LA 3S3OA 5KN8A 1MUDA 3FHFA 1NGNA 4B23A 1M3HA 4IKFA 1LMZA 2NOFA 1KG6A 3CWUA 2NOHA 3S3MA 3LCNA 4BE0A 1MUNA 1U84A 2XHIA 1PU6A 1MPGA 1XG7A 3IHOA 3N0UA 3OYGA 3OH6A 1RRSA 3FSPA 4E9HA 1KO9A 1PU7A 4UOBA 4B24A 4YPHA 3L2QA 4EW4A 1KG7A 2OFKA 1PU8A 3OYCA 3OYEA 3CWAA 4UNFA 3OYDA 1NKUA 1LWVA 1PVSA 2JPSA 1N3AA 4OFEA 2NOIA 5DPKA 1P59A 3OYHA 3L2VA 4BE1A 3G0QA 2NOZA 3OYKA 1M3QA 1YQMA 3S6IA 3CVTA 4EJYA 4EA4A 4ZTFA 3I0XA 3OYBA 4BDYA 3OYAA 2OFIA 1KG2A 2JG6A 3FHGA 3OYJA 3L2RA 4YOQA 1YQRA 4EW0A 3CWTA 1XQOA 1VRLA 2NOBA 1MUYA 1N3CA 2ABKA 3I0WA 1WEGA 1KEAA 1YQKA 2W03A 3CWSA 2YG8A 3L2UA 4DK9A 4EJZA 5FRNA 4NZGA 5FRMA 3N5NX 3OS0A 4AI4A 4BDZA 5CHZA 4E7IA 4E7JA 3OYMA 4OFAA 3F0ZA 3OH9A 4E9EA 3L2WA 3VW4A
chains in the Genus database with same CATH topology
1N39A 1KQJA 3F10A 5KN9A 1FN7A 2H56A 4B21A 1WEIA 1DIZA 2JHJA 4B22A 3IH7A 3KTUA 4E9FA 2YG9A 1YQLA 3CVSA 3OGDA 4E9GA 4AIAA 1KG5A 2NOEA 3D4VA 1HU0A 1ORPA 2NOLA 4PIIA 1KG3A 5AN4A 1P7MA 1ORNA 1LWWA 3CW7A 4OFHA 1RRQA 1KG4A 1WEFA 4EVVA 1LWYA 2I5WA 4YPRA 3KNTA 1EBMA 4EA5A 2JHNA 1XQPA 4AI5A 4HSBA 5KN8A 1MUDA 3FHFA 1NGNA 4B23A 1M3HA 1LMZA 2NOFA 1KG6A 3CWUA 2NOHA 1MUNA 2XHIA 1PU6A 1MPGA 1XG7A 3IHOA 3N0UA 1RRSA 3OH6A 3FSPA 4E9HA 1KO9A 1PU7A 4UOBA 4B24A 4YPHA 4EW4A 1KG7A 2OFKA 1PU8A 3CWAA 4UNFA 1NKUA 1LWVA 1PVSA 1N3AA 4OFEA 2NOIA 5DPKA 1P59A 3G0QA 2NOZA 1M3QA 1YQMA 3S6IA 3CVTA 4EJYA 4EA4A 3I0XA 2OFIA 1KG2A 2JG6A 3FHGA 4YOQA 1YQRA 4EW0A 3CWTA 1XQOA 1VRLA 2NOBA 1MUYA 1N3CA 2ABKA 3I0WA 1WEGA 1KEAA 1YQKA 3CWSA 2YG8A 4DK9A 4EJZA 3N5NX 4AI4A 5CHZA 4OFAA 3F0ZA 3OH9A 4E9EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N39 A;  1KQJ A;  3F10 A;  5KN9 A;  1FN7 A;  2H56 A;  4B21 A;  1WEI A;  1DIZ A;  2JHJ A;  4B22 A;  3IH7 A;  3KTU A;  4E9F A;  2YG9 A;  1YQL A;  3CVS A;  3OGD A;  4E9G A;  4AIA A;  1KG5 A;  2NOE A;  3D4V A;  1HU0 A;  1ORP A;  2NOL A;  4PII A;  1KG3 A;  5AN4 A;  1P7M A;  1ORN A;  1LWW A;  3CW7 A;  4OFH A;  1RRQ A;  1KG4 A;  1WEF A;  4EVV A;  1LWY A;  2I5W A;  4YPR A;  3KNT A;  1EBM A;  4EA5 A;  2JHN A;  1XQP A;  4AI5 A;  4HSB A;  5KN8 A;  1MUD A;  3FHF A;  1NGN A;  4B23 A;  1M3H A;  1LMZ A;  2NOF A;  1KG6 A;  3CWU A;  2NOH A;  1MUN A;  2XHI A;  1PU6 A;  1MPG A;  1XG7 A;  3IHO A;  3N0U A;  1RRS A;  3OH6 A;  3FSP A;  4E9H A;  1KO9 A;  1PU7 A;  4UOB A;  4B24 A;  4YPH A;  4EW4 A;  1KG7 A;  2OFK A;  1PU8 A;  3CWA A;  4UNF A;  1NKU A;  1LWV A;  1PVS A;  1N3A A;  4OFE A;  2NOI A;  5DPK A;  1P59 A;  3G0Q A;  2NOZ A;  1M3Q A;  1YQM A;  3S6I A;  3CVT A;  4EJY A;  4EA4 A;  3I0X A;  2OFI A;  1KG2 A;  2JG6 A;  3FHG A;  4YOQ A;  1YQR A;  4EW0 A;  3CWT A;  1XQO A;  1VRL A;  2NOB A;  1MUY A;  1N3C A;  2ABK A;  3I0W A;  1WEG A;  1KEA A;  1YQK A;  3CWS A;  2YG8 A;  4DK9 A;  4EJZ A;  3N5N X;  4AI4 A;  5CHZ A;  4OFA A;  3F0Z A;  3OH9 A;  4E9E A; 
#chains in the Genus database with same CATH topology
 1N39 A;  1KQJ A;  3NNQ A;  3F10 A;  5KN9 A;  1FN7 A;  2H56 A;  4B21 A;  4BAC A;  1WEI A;  3S3N A;  1DIZ A;  2JHJ A;  4B22 A;  3IH7 A;  3KTU A;  4E9F A;  2YG9 A;  1YQL A;  3CVS A;  3OGD A;  3OYL A;  4E9G A;  4AIA A;  1KG5 A;  2NOE A;  3D4V A;  4ZTJ A;  4E7K A;  1HU0 A;  3R2X C;  1ORP A;  2NOL A;  4PII A;  1KG3 A;  4E7H A;  5AN4 A;  1P7M A;  1ORN A;  1LWW A;  3CW7 A;  4OFH A;  3OYF A;  1RRQ A;  3OYI A;  5FRO A;  1KG4 A;  1WEF A;  4EVV A;  4BE2 A;  1LWY A;  2I5W A;  4YPR A;  2W04 A;  2V75 A;  3KNT A;  3OS2 A;  3OYN A;  1EBM A;  3OS1 A;  4EA5 A;  2JHN A;  3OY9 A;  1XQP A;  4AI5 A;  4HSB A;  4E7L A;  3S3O A;  5KN8 A;  1MUD A;  3FHF A;  1NGN A;  4B23 A;  1M3H A;  4IKF A;  1LMZ A;  2NOF A;  1KG6 A;  3CWU A;  2NOH A;  3S3M A;  3LCN A;  4BE0 A;  1MUN A;  1U84 A;  2XHI A;  1PU6 A;  1MPG A;  1XG7 A;  3IHO A;  3N0U A;  3OYG A;  3OH6 A;  1RRS A;  3FSP A;  4E9H A;  1KO9 A;  1PU7 A;  4UOB A;  4B24 A;  4YPH A;  3L2Q A;  4EW4 A;  1KG7 A;  2OFK A;  1PU8 A;  3OYC A;  3OYE A;  3CWA A;  4UNF A;  3OYD A;  1NKU A;  1LWV A;  1PVS A;  2JPS A;  1N3A A;  4OFE A;  2NOI A;  5DPK A;  1P59 A;  3OYH A;  3L2V A;  4BE1 A;  3G0Q A;  2NOZ A;  3OYK A;  1M3Q A;  1YQM A;  3S6I A;  3CVT A;  4EJY A;  4EA4 A;  4ZTF A;  3I0X A;  3OYB A;  4BDY A;  3OYA A;  2OFI A;  1KG2 A;  2JG6 A;  3FHG A;  3OYJ A;  3L2R A;  4YOQ A;  1YQR A;  4EW0 A;  3CWT A;  1XQO A;  1VRL A;  2NOB A;  1MUY A;  1N3C A;  2ABK A;  3I0W A;  1WEG A;  1KEA A;  1YQK A;  2W03 A;  3CWS A;  2YG8 A;  3L2U A;  4DK9 A;  4EJZ A;  5FRN A;  4NZG A;  5FRM A;  3N5N X;  3OS0 A;  4AI4 A;  4BDZ A;  5CHZ A;  4E7I A;  4E7J A;  3OYM A;  4OFA A;  3F0Z A;  3OH9 A;  4E9E A;  3L2W A;  3VW4 A; 
#chains in the Genus database with same CATH homology
 1N39 A;  1KQJ A;  3F10 A;  5KN9 A;  1FN7 A;  2H56 A;  4B21 A;  1WEI A;  1DIZ A;  2JHJ A;  4B22 A;  3IH7 A;  3KTU A;  4E9F A;  2YG9 A;  1YQL A;  3CVS A;  3OGD A;  4E9G A;  4AIA A;  1KG5 A;  2NOE A;  3D4V A;  1HU0 A;  1ORP A;  2NOL A;  4PII A;  1KG3 A;  5AN4 A;  1P7M A;  1ORN A;  1LWW A;  3CW7 A;  4OFH A;  1RRQ A;  1KG4 A;  1WEF A;  4EVV A;  1LWY A;  2I5W A;  4YPR A;  3KNT A;  1EBM A;  4EA5 A;  2JHN A;  1XQP A;  4AI5 A;  4HSB A;  5KN8 A;  1MUD A;  3FHF A;  1NGN A;  4B23 A;  1M3H A;  1LMZ A;  2NOF A;  1KG6 A;  3CWU A;  2NOH A;  1MUN A;  2XHI A;  1PU6 A;  1MPG A;  1XG7 A;  3IHO A;  3N0U A;  1RRS A;  3OH6 A;  3FSP A;  4E9H A;  1KO9 A;  1PU7 A;  4UOB A;  4B24 A;  4YPH A;  4EW4 A;  1KG7 A;  2OFK A;  1PU8 A;  3CWA A;  4UNF A;  1NKU A;  1LWV A;  1PVS A;  1N3A A;  4OFE A;  2NOI A;  5DPK A;  1P59 A;  3G0Q A;  2NOZ A;  1M3Q A;  1YQM A;  3S6I A;  3CVT A;  4EJY A;  4EA4 A;  3I0X A;  2OFI A;  1KG2 A;  2JG6 A;  3FHG A;  4YOQ A;  1YQR A;  4EW0 A;  3CWT A;  1XQO A;  1VRL A;  2NOB A;  1MUY A;  1N3C A;  2ABK A;  3I0W A;  1WEG A;  1KEA A;  1YQK A;  3CWS A;  2YG8 A;  4DK9 A;  4EJZ A;  3N5N X;  4AI4 A;  5CHZ A;  4OFA A;  3F0Z A;  3OH9 A;  4E9E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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