4OFHA

Structural basis for thymine glycosylase activity on t:o6-methylg mismatch by methyl-cpg binding domain protein 4: implications for roles of arg468 in mismatch recognition and catalysis
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
141
structure length
141
Chain Sequence
WTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPENHKLNKYHDWLWENHEKLS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of MBD4 bound to O6MeG:T mispair DNA
rcsb
molecule tags Hydrolase/dna
source organism Homo sapiens
molecule keywords Methyl-CpG-binding domain protein 4
total genus 51
structure length 141
sequence length 141
ec nomenclature ec 3.2.2.-:
pdb deposition date 2014-01-14
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.340.30 Mainly Alpha Orthogonal Bundle Endonuclease III; domain 1 Hypothetical protein; domain 2 4ofhA00
1KG2A 4B22A 4E9GA 3CWSA 2NOZA 1LMZA 1PU7A 3I0WA 3KNTA 5KN8A 1LWWA 1KG5A 4B23A 2OFIA 1YQRA 4OFHA 1VRLA 1WEIA 1N3AA 2YG9A 4EW4A 5AN4A 1YQKA 4YPRA 2NOLA 4OFAA 3G0QA 4B24A 1KEAA 4OFEA 4EJYA 1LWVA 4E9HA 2NOFA 1P7MA 1PU6A 1RRSA 3FHFA 4YPHA 3I0XA 1YQLA 1N39A 5KN9A 1KO9A 5CHZA 4EA5A 2XHIA 2ABKA 3CWAA 4EA4A 3FSPA 1PU8A 1KQJA 1PVSA 1M3HA 3CWUA 3F10A 2OFKA 1NKUA 5DPKA 2NOBA 2NOEA 1MUYA 3CVTA 1FN7A 4EJZA 2JHNA 1MPGA 1HU0A 1ORPA 2JG6A 4EW0A 1DIZA 1KG4A 2H56A 4AIAA 3OGDA 4E9EA 1P59A 3CW7A 3N5NX 1WEGA 1MUNA 1LWYA 2NOHA 3FHGA 4E9FA 1XG7A 4EVVA 4AI5A 3N0UA 4PIIA 1N3CA 3D4VA 1XQOA 3CWTA 3OH9A 1KG7A 1XQPA 1ORNA 1YQMA 4UOBA 3KTUA 4HSBA 4DK9A 3OH6A 3S6IA 2JHJA 3F0ZA 1KG3A 3CVSA 4UNFA 3IHOA 1MUDA 1M3QA 4B21A 4YOQA 1WEFA 1RRQA 3IH7A 4AI4A 1EBMA 2NOIA 1KG6A 2YG8A 2I5WA 1NGNA
chains in the Genus database with same CATH superfamily
1KG2A 1U84A 4B22A 4E9GA 3CWSA 2NOZA 1LMZA 1PU7A 3I0WA 3KNTA 5KN8A 1LWWA 1KG5A 3R2XC 3OYEA 4B23A 2OFIA 1YQRA 4OFHA 1VRLA 4E7HA 1WEIA 2W04A 1N3AA 2YG9A 4EW4A 5AN4A 1YQKA 3S3OA 4YPRA 2NOLA 4OFAA 2JPSA 2V75A 3G0QA 4B24A 1KEAA 4OFEA 4EJYA 1LWVA 2W03A 5FROA 4BE2A 4E9HA 2NOFA 1P7MA 1PU6A 1RRSA 3FHFA 4YPHA 4ZTJA 3I0XA 4NZGA 4E7IA 1YQLA 1N39A 5KN9A 1KO9A 5CHZA 4EA5A 2XHIA 3VW4A 2ABKA 3CWAA 3OYBA 4BDYA 4E7LA 4EA4A 3FSPA 1PU8A 3OYHA 3S3MA 1KQJA 1PVSA 1M3HA 3CWUA 5FRMA 3F10A 3L2VA 2OFKA 1NKUA 5DPKA 3L2UA 2NOBA 2NOEA 1MUYA 3CVTA 3OS0A 4E7JA 1FN7A 3OYAA 4E7KA 2JHNA 1MPGA 1HU0A 4EJZA 3OYFA 1ORPA 2JG6A 4EW0A 4BDZA 1DIZA 1KG4A 2H56A 4AIAA 3OGDA 4E9EA 3OS1A 1P59A 4BACA 3N5NX 3CW7A 3OYLA 1WEGA 1MUNA 4BE1A 1LWYA 4ZTFA 2NOHA 3FHGA 4E9FA 1XG7A 4IKFA 4EVVA 3L2RA 4AI5A 3N0UA 4PIIA 3OYKA 3OYGA 3D4VA 1N3CA 3OY9A 3NNQA 1XQOA 3L2QA 3CWTA 3OH9A 3OYIA 1KG7A 3OS2A 3OYJA 1XQPA 1ORNA 1YQMA 4UOBA 3OYCA 3KTUA 4HSBA 3L2WA 4DK9A 3OH6A 3S6IA 2JHJA 3F0ZA 1KG3A 3CVSA 4UNFA 3LCNA 3IHOA 1MUDA 1M3QA 4B21A 3OYDA 4YOQA 3S3NA 1WEFA 5FRNA 4BE0A 1RRQA 3OYMA 3IH7A 4AI4A 3OYNA 1EBMA 2NOIA 1KG6A 2YG8A 2I5WA 1NGNA
chains in the Genus database with same CATH topology
1KG2A 4B22A 4E9GA 3CWSA 2NOZA 1LMZA 1PU7A 3I0WA 3KNTA 5KN8A 1LWWA 1KG5A 4B23A 2OFIA 1YQRA 4OFHA 1VRLA 1WEIA 1N3AA 2YG9A 4EW4A 5AN4A 1YQKA 4YPRA 2NOLA 4OFAA 3G0QA 4B24A 1KEAA 4OFEA 4EJYA 1LWVA 4E9HA 2NOFA 1P7MA 1PU6A 1RRSA 3FHFA 4YPHA 3I0XA 1YQLA 1N39A 5KN9A 1KO9A 5CHZA 4EA5A 2XHIA 2ABKA 3CWAA 4EA4A 3FSPA 1PU8A 1KQJA 1PVSA 1M3HA 3CWUA 3F10A 2OFKA 1NKUA 5DPKA 2NOBA 2NOEA 1MUYA 3CVTA 1FN7A 4EJZA 2JHNA 1MPGA 1HU0A 1ORPA 2JG6A 4EW0A 1DIZA 1KG4A 2H56A 4AIAA 3OGDA 4E9EA 1P59A 3CW7A 3N5NX 1WEGA 1MUNA 1LWYA 2NOHA 3FHGA 4E9FA 1XG7A 4EVVA 4AI5A 3N0UA 4PIIA 1N3CA 3D4VA 1XQOA 3CWTA 3OH9A 1KG7A 1XQPA 1ORNA 1YQMA 4UOBA 3KTUA 4HSBA 4DK9A 3OH6A 3S6IA 2JHJA 3F0ZA 1KG3A 3CVSA 4UNFA 3IHOA 1MUDA 1M3QA 4B21A 4YOQA 1WEFA 1RRQA 3IH7A 4AI4A 1EBMA 2NOIA 1KG6A 2YG8A 2I5WA 1NGNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KG2 A;  4B22 A;  4E9G A;  3CWS A;  2NOZ A;  1LMZ A;  1PU7 A;  3I0W A;  3KNT A;  5KN8 A;  1LWW A;  1KG5 A;  4B23 A;  2OFI A;  1YQR A;  4OFH A;  1VRL A;  1WEI A;  1N3A A;  2YG9 A;  4EW4 A;  5AN4 A;  1YQK A;  4YPR A;  2NOL A;  4OFA A;  3G0Q A;  4B24 A;  1KEA A;  4OFE A;  4EJY A;  1LWV A;  4E9H A;  2NOF A;  1P7M A;  1PU6 A;  1RRS A;  3FHF A;  4YPH A;  3I0X A;  1YQL A;  1N39 A;  5KN9 A;  1KO9 A;  5CHZ A;  4EA5 A;  2XHI A;  2ABK A;  3CWA A;  4EA4 A;  3FSP A;  1PU8 A;  1KQJ A;  1PVS A;  1M3H A;  3CWU A;  3F10 A;  2OFK A;  1NKU A;  5DPK A;  2NOB A;  2NOE A;  1MUY A;  3CVT A;  1FN7 A;  4EJZ A;  2JHN A;  1MPG A;  1HU0 A;  1ORP A;  2JG6 A;  4EW0 A;  1DIZ A;  1KG4 A;  2H56 A;  4AIA A;  3OGD A;  4E9E A;  1P59 A;  3CW7 A;  3N5N X;  1WEG A;  1MUN A;  1LWY A;  2NOH A;  3FHG A;  4E9F A;  1XG7 A;  4EVV A;  4AI5 A;  3N0U A;  4PII A;  1N3C A;  3D4V A;  1XQO A;  3CWT A;  3OH9 A;  1KG7 A;  1XQP A;  1ORN A;  1YQM A;  4UOB A;  3KTU A;  4HSB A;  4DK9 A;  3OH6 A;  3S6I A;  2JHJ A;  3F0Z A;  1KG3 A;  3CVS A;  4UNF A;  3IHO A;  1MUD A;  1M3Q A;  4B21 A;  4YOQ A;  1WEF A;  1RRQ A;  3IH7 A;  4AI4 A;  1EBM A;  2NOI A;  1KG6 A;  2YG8 A;  2I5W A;  1NGN A; 
#chains in the Genus database with same CATH topology
 1KG2 A;  1U84 A;  4B22 A;  4E9G A;  3CWS A;  2NOZ A;  1LMZ A;  1PU7 A;  3I0W A;  3KNT A;  5KN8 A;  1LWW A;  1KG5 A;  3R2X C;  3OYE A;  4B23 A;  2OFI A;  1YQR A;  4OFH A;  1VRL A;  4E7H A;  1WEI A;  2W04 A;  1N3A A;  2YG9 A;  4EW4 A;  5AN4 A;  1YQK A;  3S3O A;  4YPR A;  2NOL A;  4OFA A;  2JPS A;  2V75 A;  3G0Q A;  4B24 A;  1KEA A;  4OFE A;  4EJY A;  1LWV A;  2W03 A;  5FRO A;  4BE2 A;  4E9H A;  2NOF A;  1P7M A;  1PU6 A;  1RRS A;  3FHF A;  4YPH A;  4ZTJ A;  3I0X A;  4NZG A;  4E7I A;  1YQL A;  1N39 A;  5KN9 A;  1KO9 A;  5CHZ A;  4EA5 A;  2XHI A;  3VW4 A;  2ABK A;  3CWA A;  3OYB A;  4BDY A;  4E7L A;  4EA4 A;  3FSP A;  1PU8 A;  3OYH A;  3S3M A;  1KQJ A;  1PVS A;  1M3H A;  3CWU A;  5FRM A;  3F10 A;  3L2V A;  2OFK A;  1NKU A;  5DPK A;  3L2U A;  2NOB A;  2NOE A;  1MUY A;  3CVT A;  3OS0 A;  4E7J A;  1FN7 A;  3OYA A;  4E7K A;  2JHN A;  1MPG A;  1HU0 A;  4EJZ A;  3OYF A;  1ORP A;  2JG6 A;  4EW0 A;  4BDZ A;  1DIZ A;  1KG4 A;  2H56 A;  4AIA A;  3OGD A;  4E9E A;  3OS1 A;  1P59 A;  4BAC A;  3N5N X;  3CW7 A;  3OYL A;  1WEG A;  1MUN A;  4BE1 A;  1LWY A;  4ZTF A;  2NOH A;  3FHG A;  4E9F A;  1XG7 A;  4IKF A;  4EVV A;  3L2R A;  4AI5 A;  3N0U A;  4PII A;  3OYK A;  3OYG A;  3D4V A;  1N3C A;  3OY9 A;  3NNQ A;  1XQO A;  3L2Q A;  3CWT A;  3OH9 A;  3OYI A;  1KG7 A;  3OS2 A;  3OYJ A;  1XQP A;  1ORN A;  1YQM A;  4UOB A;  3OYC A;  3KTU A;  4HSB A;  3L2W A;  4DK9 A;  3OH6 A;  3S6I A;  2JHJ A;  3F0Z A;  1KG3 A;  3CVS A;  4UNF A;  3LCN A;  3IHO A;  1MUD A;  1M3Q A;  4B21 A;  3OYD A;  4YOQ A;  3S3N A;  1WEF A;  5FRN A;  4BE0 A;  1RRQ A;  3OYM A;  3IH7 A;  4AI4 A;  3OYN A;  1EBM A;  2NOI A;  1KG6 A;  2YG8 A;  2I5W A;  1NGN A; 
#chains in the Genus database with same CATH homology
 1KG2 A;  4B22 A;  4E9G A;  3CWS A;  2NOZ A;  1LMZ A;  1PU7 A;  3I0W A;  3KNT A;  5KN8 A;  1LWW A;  1KG5 A;  4B23 A;  2OFI A;  1YQR A;  4OFH A;  1VRL A;  1WEI A;  1N3A A;  2YG9 A;  4EW4 A;  5AN4 A;  1YQK A;  4YPR A;  2NOL A;  4OFA A;  3G0Q A;  4B24 A;  1KEA A;  4OFE A;  4EJY A;  1LWV A;  4E9H A;  2NOF A;  1P7M A;  1PU6 A;  1RRS A;  3FHF A;  4YPH A;  3I0X A;  1YQL A;  1N39 A;  5KN9 A;  1KO9 A;  5CHZ A;  4EA5 A;  2XHI A;  2ABK A;  3CWA A;  4EA4 A;  3FSP A;  1PU8 A;  1KQJ A;  1PVS A;  1M3H A;  3CWU A;  3F10 A;  2OFK A;  1NKU A;  5DPK A;  2NOB A;  2NOE A;  1MUY A;  3CVT A;  1FN7 A;  4EJZ A;  2JHN A;  1MPG A;  1HU0 A;  1ORP A;  2JG6 A;  4EW0 A;  1DIZ A;  1KG4 A;  2H56 A;  4AIA A;  3OGD A;  4E9E A;  1P59 A;  3CW7 A;  3N5N X;  1WEG A;  1MUN A;  1LWY A;  2NOH A;  3FHG A;  4E9F A;  1XG7 A;  4EVV A;  4AI5 A;  3N0U A;  4PII A;  1N3C A;  3D4V A;  1XQO A;  3CWT A;  3OH9 A;  1KG7 A;  1XQP A;  1ORN A;  1YQM A;  4UOB A;  3KTU A;  4HSB A;  4DK9 A;  3OH6 A;  3S6I A;  2JHJ A;  3F0Z A;  1KG3 A;  3CVS A;  4UNF A;  3IHO A;  1MUD A;  1M3Q A;  4B21 A;  4YOQ A;  1WEF A;  1RRQ A;  3IH7 A;  4AI4 A;  1EBM A;  2NOI A;  1KG6 A;  2YG8 A;  2I5W A;  1NGN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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