4HGKA

Shark ignar variable domain
Total Genus 188
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
188
sequence length
490
structure length
483
Chain Sequence
KSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis.
pubmed doi rcsb
molecule keywords Serum albumin
molecule tags Immune system
source organism Homo sapiens
total genus 188
structure length 483
sequence length 490
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4hgkA02
1LOTA 1GNJA 2XVUA 1HK4A 4LB2A 1KW2A 1E7CA 2BXEA 1J78A 4G03A 4F5TA 2BXCA 5ID7A 3JQZA 1E7AA 3LU7A 2BX8A 4Z69A 1E7EA 1E7HA 5HOZA 4LA0A 4E99A 2BXIA 2BXLA 2BXDA 5IIHA 4HGMB 2BXHA 5IFOA 5FUOA 3B9LA 2XVWA 4F5VA 2VUFA 5DQFA 5ID9A 2BXPA 2VUEA 1BM0A 1N5UA 3V09A 4G04A 5IIUA 3A73A 4IW1A 4N0FD 3TDLA 5IIXA 1HK2A 4ZBRA 1E7IA 3LU6A 5IJEA 2XW0A 2BXNA 4L8UA 4F5SA 1E78A 4J2VA 1J7EA 4PO0A 3SQJA 1E7GA 2XVVA 4JK4A 1HK5A 4LB9A 2BXBA 3CX9A 1HA2A 4HGKA 2XW1A 1HK3A 5DBYA 2BXKA 1H9ZA 2I2ZA 3V03A 1BKEA 2BXQA 2BXGA 1HK1A 1GNIA 4L9KA 4N0UD 4BKEA 1E7BA 4OR0A 2BXFA 2BXOA 3B9MA 3V08A 1BJ5A 5GHKA 2XSIA 2I30A 1TF0A 4LUFA 4S1YA 1AO6A 3LU8A 2VDBA 2BXAA 4K71A 1MA9A 4EMXA 4OT2A 1KXPD 2BXMA 2XVQA 1E7FA 3JRYA 2YDFA 4K2CA 1O9XA 5IJ5A 4ZBQA 4F5UA 4L9QA 4LUHA 1UORA 3UIVA 5IJFA 4IW2A
chains in the Genus database with same CATH superfamily
1LOTA 1GNJA 4ZCGA 2XVUA 1HK4A 2KBZA 4Z9OA 4I9OA 4GDLB 4LB2A 1KW2A 1E7CA 2EFEA 2BXEA 1J78A 1KDXA 4TQ0A 4G03A 4F5TA 2BXCA 3NVMA 5ID7A 3JQZA 1E7AA 2AGHB 2DYMA 2NQOA 5B5TA 3H3AA 3LU7A 2BX8A 4MBEC 4C31B 4M70B 2Z8JA 4Z69A 1E7EA 1E7HA 1MIWA 2QMCA 5HOZA 2LQHA 4DM0A 4FK5B 4LA0A 3ICXA 4E99A 4WA6B 1NT2B 2BXIA 2BXLA 2BXDA 2EFHA 2LOQA 3NVKA 5BPKA 5IIHA 5GINA 2BXHA 4HGMB 5IFOA 4GDKB 5FUOA 4G01A 3B9LA 2XVWA 4F5VA 2VUFA 5DQFA 5ID9A 4BY9C 5GIPA 4D7XA 2CKXA 2BXPA 2VUEA 1MM8A 4GG2A 3FWCC 3BPJA 1BM0A 2DG5A 2XMOA 1VFIA 1N5UA 3V09A 4G04A 3WHQA 1IJGA 5IIUA 1SB0A 5D7GA 3A73A 4IW1A 4N0FD 3TDLA 5IIXA 1HK2A 4FIPB 2LQIA 2LXTA 3MHSB 4ZBRA 1E7IA 4TQ1A 3LU6A 5IJEA 2XW0A 2BXNA 4L8UA 1FOUA 4F5SA 1MIVA 3FNMA 1E78A 4GDXA 2Z8KA 1J7EA 4J2VA 4DHXB 4PO0A 3SQJA 1E7GA 2XVVA 4JK4A 1HK5A 4LB9A 2BXBA 3WHRA 5GIOA 3CX9A 1HA2A 3MHHB 2E0XA 2OT3A 4HGKA 3SIUB 1H5WA 4ZBKA 3ECPA 1LNSA 3W1SA 1JNBA 2XW1A 1HK3A 5DBYA 2Z8IA 3SIVB 1MUSA 3G9KD 2BXKA 3GA9L 1H9ZA 3KJLA 2I2ZA 3V03A 4OTTA 1BKEA 3FWBC 4ZUXV 2BXQA 3GQUA 2BXGA 1HK1A 1GNIA 2AJEA 4L9KA 4N0UD 3A75A 4BKEA 1E7BA 2DBWA 4OR0A 3NVIA 3NMUA 2BXFA 1MIYA 2BXOA 2DYOA 3B9MA 1BJ5A 4NAWB 2GUTA 5GHKA 3V08A 2XSIA 1TF0A 2I30A 2EFCA 1TXUA 4LUFA 1MUHA 4S1YA 1AO6A 3WHSA 2DBUA 4OTUA 3LU8A 3H37A 2VDBA 2BXAA 1VZSA 4FJCB 4K71A 2DBXA 3VQIA 2OZBB 2LXSA 1MA9A 4EMXA 4OT2A 3M99C 1KXPD 2BXMA 4N3ZA 2XVQA 1E7FA 3JRYA 2E0YA 2YDFA 2NNWA 4K2CA 1O9XA 4ZC6A 5IJ5A 3KIKA 4ZBQA 2EFDA 2ROHA 4F5UA 3GQXA 4L9QA 4LUHA 2QHBA 2QM6A 1UORA 2V36A 3UIVA 2JUHA 5IJFA 4IW2A 4W4UB 2KWFA 2K0NA 3PLAA
chains in the Genus database with same CATH topology
1LOTA 1GNJA 4ZCGA 2XVUA 1HK4A 2KBZA 4Z9OA 4GDLB 4LB2A 1KW2A 1E7CA 2EFEA 2BXEA 1J78A 4TQ0A 4G03A 4F5TA 2BXCA 3NVMA 5ID7A 3JQZA 1E7AA 2DYMA 2NQOA 5B5TA 3H3AA 3LU7A 2BX8A 4MBEC 4C31B 4M70B 2Z8JA 4Z69A 1E7EA 1E7HA 1MIWA 2QMCA 5HOZA 4FK5B 4LA0A 3ICXA 4E99A 4WA6B 1NT2B 2BXIA 2BXLA 2BXDA 2EFHA 2LOQA 3NVKA 5BPKA 5IIHA 5GINA 2BXHA 4HGMB 5IFOA 4GDKB 5FUOA 4G01A 3B9LA 2XVWA 4F5VA 2VUFA 5DQFA 5ID9A 4BY9C 5GIPA 2CKXA 2BXPA 2VUEA 4GG2A 3FWCC 1BM0A 2DG5A 2XMOA 1VFIA 1N5UA 3V09A 4G04A 3WHQA 1IJGA 5IIUA 5D7GA 3A73A 4IW1A 4N0FD 3TDLA 5IIXA 1HK2A 4FIPB 3MHSB 4ZBRA 1E7IA 4TQ1A 3LU6A 5IJEA 2XW0A 2BXNA 4L8UA 1FOUA 4F5SA 1MIVA 3FNMA 1E78A 4GDXA 2Z8KA 1J7EA 4J2VA 4DHXB 4PO0A 3SQJA 1E7GA 2XVVA 4JK4A 1HK5A 4LB9A 2BXBA 3WHRA 5GIOA 3CX9A 1HA2A 3MHHB 2E0XA 2OT3A 4HGKA 3SIUB 1H5WA 4ZBKA 1LNSA 3W1SA 1JNBA 2XW1A 1HK3A 5DBYA 2Z8IA 3SIVB 3G9KD 2BXKA 3GA9L 1H9ZA 3KJLA 2I2ZA 3V03A 4OTTA 1BKEA 3FWBC 4ZUXV 2BXQA 3GQUA 2BXGA 1HK1A 1GNIA 2AJEA 4L9KA 4N0UD 3A75A 4BKEA 1E7BA 2DBWA 4OR0A 3NVIA 3NMUA 2BXFA 1MIYA 2BXOA 2DYOA 3B9MA 1BJ5A 4NAWB 5GHKA 3V08A 2XSIA 2I30A 1TF0A 2EFCA 1TXUA 4LUFA 4S1YA 1AO6A 3WHSA 2DBUA 4OTUA 3LU8A 3H37A 2VDBA 2BXAA 1VZSA 4FJCB 4K71A 2DBXA 3VQIA 2OZBB 1MA9A 4EMXA 4OT2A 3M99C 1KXPD 2BXMA 4N3ZA 2XVQA 1E7FA 3JRYA 2E0YA 2YDFA 2NNWA 4K2CA 1O9XA 4ZC6A 5IJ5A 3KIKA 4ZBQA 2EFDA 2ROHA 4F5UA 3GQXA 4L9QA 4LUHA 2QHBA 2QM6A 1UORA 2V36A 3UIVA 2JUHA 5IJFA 4IW2A 4W4UB 3PLAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1LOT A;  1GNJ A;  2XVU A;  1HK4 A;  4LB2 A;  1KW2 A;  1E7C A;  2BXE A;  1J78 A;  4G03 A;  4F5T A;  2BXC A;  5ID7 A;  3JQZ A;  1E7A A;  3LU7 A;  2BX8 A;  4Z69 A;  1E7E A;  1E7H A;  5HOZ A;  4LA0 A;  4E99 A;  2BXI A;  2BXL A;  2BXD A;  5IIH A;  4HGM B;  2BXH A;  5IFO A;  5FUO A;  3B9L A;  2XVW A;  4F5V A;  2VUF A;  5DQF A;  5ID9 A;  2BXP A;  2VUE A;  1BM0 A;  1N5U A;  3V09 A;  4G04 A;  5IIU A;  3A73 A;  4IW1 A;  4N0F D;  3TDL A;  5IIX A;  1HK2 A;  4ZBR A;  1E7I A;  3LU6 A;  5IJE A;  2XW0 A;  2BXN A;  4L8U A;  4F5S A;  1E78 A;  4J2V A;  1J7E A;  4PO0 A;  3SQJ A;  1E7G A;  2XVV A;  4JK4 A;  1HK5 A;  4LB9 A;  2BXB A;  3CX9 A;  1HA2 A;  4HGK A;  2XW1 A;  1HK3 A;  5DBY A;  2BXK A;  1H9Z A;  2I2Z A;  3V03 A;  1BKE A;  2BXQ A;  2BXG A;  1HK1 A;  1GNI A;  4L9K A;  4N0U D;  4BKE A;  1E7B A;  4OR0 A;  2BXF A;  2BXO A;  3B9M A;  3V08 A;  1BJ5 A;  5GHK A;  2XSI A;  2I30 A;  1TF0 A;  4LUF A;  4S1Y A;  1AO6 A;  3LU8 A;  2VDB A;  2BXA A;  4K71 A;  1MA9 A;  4EMX A;  4OT2 A;  1KXP D;  2BXM A;  2XVQ A;  1E7F A;  3JRY A;  2YDF A;  4K2C A;  1O9X A;  5IJ5 A;  4ZBQ A;  4F5U A;  4L9Q A;  4LUH A;  1UOR A;  3UIV A;  5IJF A;  4IW2 A; 
#chains in the Genus database with same CATH topology
 1LOT A;  1GNJ A;  4ZCG A;  2XVU A;  1HK4 A;  2KBZ A;  4Z9O A;  4I9O A;  4GDL B;  4LB2 A;  1KW2 A;  1E7C A;  2EFE A;  2BXE A;  1J78 A;  1KDX A;  4TQ0 A;  4G03 A;  4F5T A;  2BXC A;  3NVM A;  5ID7 A;  3JQZ A;  1E7A A;  2AGH B;  2DYM A;  2NQO A;  5B5T A;  3H3A A;  3LU7 A;  2BX8 A;  4MBE C;  4C31 B;  4M70 B;  2Z8J A;  4Z69 A;  1E7E A;  1E7H A;  1MIW A;  2QMC A;  5HOZ A;  2LQH A;  4DM0 A;  4FK5 B;  4LA0 A;  3ICX A;  4E99 A;  4WA6 B;  1NT2 B;  2BXI A;  2BXL A;  2BXD A;  2EFH A;  2LOQ A;  3NVK A;  5BPK A;  5IIH A;  5GIN A;  2BXH A;  4HGM B;  5IFO A;  4GDK B;  5FUO A;  4G01 A;  3B9L A;  2XVW A;  4F5V A;  2VUF A;  5DQF A;  5ID9 A;  4BY9 C;  5GIP A;  4D7X A;  2CKX A;  2BXP A;  2VUE A;  1MM8 A;  4GG2 A;  3FWC C;  3BPJ A;  1BM0 A;  2DG5 A;  2XMO A;  1VFI A;  1N5U A;  3V09 A;  4G04 A;  3WHQ A;  1IJG A;  5IIU A;  1SB0 A;  5D7G A;  3A73 A;  4IW1 A;  4N0F D;  3TDL A;  5IIX A;  1HK2 A;  4FIP B;  2LQI A;  2LXT A;  3MHS B;  4ZBR A;  1E7I A;  4TQ1 A;  3LU6 A;  5IJE A;  2XW0 A;  2BXN A;  4L8U A;  1FOU A;  4F5S A;  1MIV A;  3FNM A;  1E78 A;  4GDX A;  2Z8K A;  1J7E A;  4J2V A;  4DHX B;  4PO0 A;  3SQJ A;  1E7G A;  2XVV A;  4JK4 A;  1HK5 A;  4LB9 A;  2BXB A;  3WHR A;  5GIO A;  3CX9 A;  1HA2 A;  3MHH B;  2E0X A;  2OT3 A;  4HGK A;  3SIU B;  1H5W A;  4ZBK A;  3ECP A;  1LNS A;  3W1S A;  1JNB A;  2XW1 A;  1HK3 A;  5DBY A;  2Z8I A;  3SIV B;  1MUS A;  3G9K D;  2BXK A;  3GA9 L;  1H9Z A;  3KJL A;  2I2Z A;  3V03 A;  4OTT A;  1BKE A;  3FWB C;  4ZUX V;  2BXQ A;  3GQU A;  2BXG A;  1HK1 A;  1GNI A;  2AJE A;  4L9K A;  4N0U D;  3A75 A;  4BKE A;  1E7B A;  2DBW A;  4OR0 A;  3NVI A;  3NMU A;  2BXF A;  1MIY A;  2BXO A;  2DYO A;  3B9M A;  1BJ5 A;  4NAW B;  2GUT A;  5GHK A;  3V08 A;  2XSI A;  1TF0 A;  2I30 A;  2EFC A;  1TXU A;  4LUF A;  1MUH A;  4S1Y A;  1AO6 A;  3WHS A;  2DBU A;  4OTU A;  3LU8 A;  3H37 A;  2VDB A;  2BXA A;  1VZS A;  4FJC B;  4K71 A;  2DBX A;  3VQI A;  2OZB B;  2LXS A;  1MA9 A;  4EMX A;  4OT2 A;  3M99 C;  1KXP D;  2BXM A;  4N3Z A;  2XVQ A;  1E7F A;  3JRY A;  2E0Y A;  2YDF A;  2NNW A;  4K2C A;  1O9X A;  4ZC6 A;  5IJ5 A;  3KIK A;  4ZBQ A;  2EFD A;  2ROH A;  4F5U A;  3GQX A;  4L9Q A;  4LUH A;  2QHB A;  2QM6 A;  1UOR A;  2V36 A;  3UIV A;  2JUH A;  5IJF A;  4IW2 A;  4W4U B;  2KWF A;  2K0N A;  3PLA A; 
#chains in the Genus database with same CATH homology
 1LOT A;  1GNJ A;  4ZCG A;  2XVU A;  1HK4 A;  2KBZ A;  4Z9O A;  4GDL B;  4LB2 A;  1KW2 A;  1E7C A;  2EFE A;  2BXE A;  1J78 A;  4TQ0 A;  4G03 A;  4F5T A;  2BXC A;  3NVM A;  5ID7 A;  3JQZ A;  1E7A A;  2DYM A;  2NQO A;  5B5T A;  3H3A A;  3LU7 A;  2BX8 A;  4MBE C;  4C31 B;  4M70 B;  2Z8J A;  4Z69 A;  1E7E A;  1E7H A;  1MIW A;  2QMC A;  5HOZ A;  4FK5 B;  4LA0 A;  3ICX A;  4E99 A;  4WA6 B;  1NT2 B;  2BXI A;  2BXL A;  2BXD A;  2EFH A;  2LOQ A;  3NVK A;  5BPK A;  5IIH A;  5GIN A;  2BXH A;  4HGM B;  5IFO A;  4GDK B;  5FUO A;  4G01 A;  3B9L A;  2XVW A;  4F5V A;  2VUF A;  5DQF A;  5ID9 A;  4BY9 C;  5GIP A;  2CKX A;  2BXP A;  2VUE A;  4GG2 A;  3FWC C;  1BM0 A;  2DG5 A;  2XMO A;  1VFI A;  1N5U A;  3V09 A;  4G04 A;  3WHQ A;  1IJG A;  5IIU A;  5D7G A;  3A73 A;  4IW1 A;  4N0F D;  3TDL A;  5IIX A;  1HK2 A;  4FIP B;  3MHS B;  4ZBR A;  1E7I A;  4TQ1 A;  3LU6 A;  5IJE A;  2XW0 A;  2BXN A;  4L8U A;  1FOU A;  4F5S A;  1MIV A;  3FNM A;  1E78 A;  4GDX A;  2Z8K A;  1J7E A;  4J2V A;  4DHX B;  4PO0 A;  3SQJ A;  1E7G A;  2XVV A;  4JK4 A;  1HK5 A;  4LB9 A;  2BXB A;  3WHR A;  5GIO A;  3CX9 A;  1HA2 A;  3MHH B;  2E0X A;  2OT3 A;  4HGK A;  3SIU B;  1H5W A;  4ZBK A;  1LNS A;  3W1S A;  1JNB A;  2XW1 A;  1HK3 A;  5DBY A;  2Z8I A;  3SIV B;  3G9K D;  2BXK A;  3GA9 L;  1H9Z A;  3KJL A;  2I2Z A;  3V03 A;  4OTT A;  1BKE A;  3FWB C;  4ZUX V;  2BXQ A;  3GQU A;  2BXG A;  1HK1 A;  1GNI A;  2AJE A;  4L9K A;  4N0U D;  3A75 A;  4BKE A;  1E7B A;  2DBW A;  4OR0 A;  3NVI A;  3NMU A;  2BXF A;  1MIY A;  2BXO A;  2DYO A;  3B9M A;  1BJ5 A;  4NAW B;  5GHK A;  3V08 A;  2XSI A;  2I30 A;  1TF0 A;  2EFC A;  1TXU A;  4LUF A;  4S1Y A;  1AO6 A;  3WHS A;  2DBU A;  4OTU A;  3LU8 A;  3H37 A;  2VDB A;  2BXA A;  1VZS A;  4FJC B;  4K71 A;  2DBX A;  3VQI A;  2OZB B;  1MA9 A;  4EMX A;  4OT2 A;  3M99 C;  1KXP D;  2BXM A;  4N3Z A;  2XVQ A;  1E7F A;  3JRY A;  2E0Y A;  2YDF A;  2NNW A;  4K2C A;  1O9X A;  4ZC6 A;  5IJ5 A;  3KIK A;  4ZBQ A;  2EFD A;  2ROH A;  4F5U A;  3GQX A;  4L9Q A;  4LUH A;  2QHB A;  2QM6 A;  1UOR A;  2V36 A;  3UIV A;  2JUH A;  5IJF A;  4IW2 A;  4W4U B;  3PLA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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