4L9KA

X-ray study of human serum albumin complexed with camptothecin
Total Genus 223
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
223
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule keywords SERUM ALBUMIN
molecule tags Transport protein
total genus 223
structure length 578
sequence length 578
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-06-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4l9kA05
4ZBRA 2XVWA 1HK4A 2YDFA 4F5UA 2BXBA 1E7AA 5ID7A 3V03A 1GNJA 3B9LA 4EMXA 5IIXA 4F5SA 3LU6A 4L9QA 3V08A 2BX8A 2BXNA 1E7HA 4IW2A 2BXIA 4OT2A 1N5UA 1J78A 3JRYA 3V09A 2XW0A 5IIUA 1J7EA 2BXLA 5IFOA 3LU7A 2BXHA 1MA9A 4N0FD 1E7GA 4E99A 2VUEA 1HA2A 5IJFA 1HK3A 5ID9A 2BXKA 1BJ5A 4LA0A 4LUHA 1O9XA 2VUFA 2I2ZA 1E7FA 2BXOA 4ZBQA 2BXEA 1GNIA 4L9KA 1LOTA 1E7BA 3JQZA 3SQJA 3CX9A 2XVQA 3B9MA 5IJ5A 2BXAA 1BM0A 4G03A 4IW1A 2XSIA 1E7IA 4OR0A 1UORA 2BXMA 5DQFA 1KW2A 4L8UA 5IJEA 4BKEA 2BXFA 4PO0A 4JK4A 4F5TA 1E78A 5IIHA 2BXCA 2XVVA 2BXDA 2XVUA 1E7CA 4G04A 4S1YA 1HK2A 2BXPA 1H9ZA 2I30A 5DBYA 4LUFA 1HK1A 4F5VA 4LB9A 1HK5A 4LB2A 3UIVA 1E7EA 4K71A 3TDLA 1KXPD 4Z69A 4HGMB 3A73A 1AO6A 1BKEA 2XW1A 4N0UD 2VDBA 4J2VA 1TF0A 4HGKA 4K2CA 5FUOA 5GHKA 2BXGA 5HOZA 3LU8A 2BXQA
chains in the Genus database with same CATH superfamily
4D7XA 4ZBRA 4DHXB 2E0YA 4GDXA 2XVWA 1HK4A 3KIKA 5GIPA 2YDFA 3VQIA 4F5UA 1H5WA 2LQIA 4I9OA 2BXBA 2V36A 3G9KD 3WHRA 2KBZA 1E7AA 3ECPA 2DBXA 2NNWA 1MUSA 2K0NA 4G01A 1NT2B 2EFDA 5BPKA 5ID7A 2Z8KA 5D7GA 3V03A 1GNJA 3B9LA 2DBWA 2DYMA 4EMXA 3FWCC 5IIXA 3NVMA 4F5SA 1MUHA 3LU6A 4L9QA 3V08A 2BX8A 2BXNA 4MBEC 1E7HA 4OTUA 4DM0A 4IW2A 2BXIA 1MIVA 4OT2A 2GUTA 4FK5B 1N5UA 1J78A 3JRYA 3MHSB 3NVIA 2JUHA 3V09A 2LOQA 2XW0A 3NVKA 5IIUA 1J7EA 2EFCA 2BXLA 2EFHA 5IFOA 3LU7A 4BY9C 2BXHA 1MA9A 4N0FD 1VZSA 4N3ZA 1E7GA 4FIPB 4NAWB 3WHQA 2NQOA 2VUEA 4E99A 3H3AA 1HA2A 5IJFA 4TQ0A 4TQ1A 1HK3A 5ID9A 2BXKA 1MIYA 1BJ5A 1KDXA 4LA0A 4GDKB 1O9XA 2VUFA 4LUHA 2QHBA 2I2ZA 1E7FA 3FWBC 2BXOA 4ZC6A 4ZBQA 1IJGA 2BXEA 1GNIA 5B5TA 4L9KA 1LOTA 4C31B 5GIOA 2QM6A 1LNSA 2LXTA 1E7BA 3H37A 1MM8A 2LXSA 1TXUA 3JQZA 3SQJA 3CX9A 2XVQA 3SIVB 3SIUB 3B9MA 5IJ5A 2BXAA 1BM0A 4ZCGA 4G03A 4IW1A 4WA6B 2E0XA 2LQHA 1E7IA 2XSIA 4OR0A 4GDLB 4ZBKA 1SB0A 2Z8IA 1UORA 2BXMA 2DBUA 5DQFA 3M99C 1KW2A 2EFEA 4L8UA 3WHSA 5IJEA 4BKEA 2BXFA 4PO0A 4JK4A 4F5TA 3PLAA 1E78A 3GA9L 2OZBB 3BPJA 5IIHA 2BXCA 2XVVA 2BXDA 4M70B 4W4UB 2XVUA 1E7CA 4G04A 2CKXA 4S1YA 1HK2A 2BXPA 1H9ZA 1MIWA 3KJLA 2I30A 5DBYA 4LUFA 4GG2A 1HK1A 2OT3A 1JNBA 3MHHB 4F5VA 4LB9A 1FOUA 3A75A 2KWFA 4OTTA 1HK5A 4LB2A 3UIVA 1E7EA 4ZUXV 2XMOA 4K71A 3TDLA 4Z9OA 1KXPD 2ROHA 4Z69A 2DG5A 4HGMB 4FJCB 3A73A 1AO6A 1BKEA 2AJEA 3FNMA 2XW1A 3ICXA 4N0UD 1VFIA 3GQUA 2VDBA 3W1SA 2AGHB 4J2VA 1TF0A 4HGKA 4K2CA 3GQXA 5GINA 5FUOA 5GHKA 2BXGA 2QMCA 5HOZA 3NMUA 3LU8A 2Z8JA 2BXQA 2DYOA
chains in the Genus database with same CATH topology
4ZBRA 4DHXB 2E0YA 4GDXA 2XVWA 1HK4A 3KIKA 5GIPA 2YDFA 3VQIA 4F5UA 1H5WA 2BXBA 2V36A 3G9KD 3WHRA 2KBZA 1E7AA 2DBXA 2NNWA 4G01A 1NT2B 2EFDA 5BPKA 5ID7A 2Z8KA 5D7GA 3V03A 1GNJA 3B9LA 2DBWA 2DYMA 4EMXA 3FWCC 5IIXA 3NVMA 4F5SA 3LU6A 4L9QA 3V08A 2BX8A 2BXNA 4MBEC 1E7HA 4OTUA 4IW2A 2BXIA 1MIVA 4OT2A 4FK5B 1N5UA 1J78A 3JRYA 3MHSB 3NVIA 2JUHA 3V09A 2LOQA 2XW0A 3NVKA 5IIUA 1J7EA 2EFCA 2BXLA 2EFHA 5IFOA 3LU7A 4BY9C 2BXHA 1MA9A 4N0FD 1VZSA 4N3ZA 1E7GA 4FIPB 4NAWB 3WHQA 2NQOA 2VUEA 4E99A 3H3AA 1HA2A 5IJFA 4TQ0A 4TQ1A 1HK3A 5ID9A 2BXKA 1MIYA 1BJ5A 4LA0A 4GDKB 1O9XA 2VUFA 4LUHA 2QHBA 2I2ZA 1E7FA 3FWBC 2BXOA 4ZC6A 4ZBQA 1IJGA 2BXEA 1GNIA 5B5TA 4L9KA 1LOTA 4C31B 5GIOA 2QM6A 1LNSA 1E7BA 3H37A 1TXUA 3JQZA 3SQJA 3CX9A 2XVQA 3SIVB 3SIUB 3B9MA 5IJ5A 2BXAA 1BM0A 4ZCGA 4G03A 4IW1A 4WA6B 2E0XA 2XSIA 1E7IA 4OR0A 4GDLB 4ZBKA 2Z8IA 1UORA 2BXMA 2DBUA 5DQFA 3M99C 1KW2A 2EFEA 4L8UA 3WHSA 5IJEA 4BKEA 2BXFA 4PO0A 4JK4A 4F5TA 3PLAA 1E78A 3GA9L 2OZBB 5IIHA 2BXCA 2XVVA 2BXDA 4M70B 4W4UB 2XVUA 1E7CA 4G04A 2CKXA 4S1YA 1HK2A 2BXPA 1H9ZA 1MIWA 3KJLA 2I30A 5DBYA 4LUFA 4GG2A 1HK1A 2OT3A 1JNBA 3MHHB 4F5VA 4LB9A 1FOUA 3A75A 4OTTA 1HK5A 4LB2A 3UIVA 1E7EA 4ZUXV 2XMOA 4K71A 3TDLA 4Z9OA 1KXPD 2ROHA 4Z69A 2DG5A 4HGMB 4FJCB 3A73A 1AO6A 1BKEA 2AJEA 3FNMA 2XW1A 3ICXA 4N0UD 1VFIA 3GQUA 2VDBA 3W1SA 4J2VA 1TF0A 4HGKA 4K2CA 3GQXA 5GINA 5FUOA 5GHKA 2BXGA 2QMCA 5HOZA 3NMUA 3LU8A 2Z8JA 2BXQA 2DYOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZBR A;  2XVW A;  1HK4 A;  2YDF A;  4F5U A;  2BXB A;  1E7A A;  5ID7 A;  3V03 A;  1GNJ A;  3B9L A;  4EMX A;  5IIX A;  4F5S A;  3LU6 A;  4L9Q A;  3V08 A;  2BX8 A;  2BXN A;  1E7H A;  4IW2 A;  2BXI A;  4OT2 A;  1N5U A;  1J78 A;  3JRY A;  3V09 A;  2XW0 A;  5IIU A;  1J7E A;  2BXL A;  5IFO A;  3LU7 A;  2BXH A;  1MA9 A;  4N0F D;  1E7G A;  4E99 A;  2VUE A;  1HA2 A;  5IJF A;  1HK3 A;  5ID9 A;  2BXK A;  1BJ5 A;  4LA0 A;  4LUH A;  1O9X A;  2VUF A;  2I2Z A;  1E7F A;  2BXO A;  4ZBQ A;  2BXE A;  1GNI A;  4L9K A;  1LOT A;  1E7B A;  3JQZ A;  3SQJ A;  3CX9 A;  2XVQ A;  3B9M A;  5IJ5 A;  2BXA A;  1BM0 A;  4G03 A;  4IW1 A;  2XSI A;  1E7I A;  4OR0 A;  1UOR A;  2BXM A;  5DQF A;  1KW2 A;  4L8U A;  5IJE A;  4BKE A;  2BXF A;  4PO0 A;  4JK4 A;  4F5T A;  1E78 A;  5IIH A;  2BXC A;  2XVV A;  2BXD A;  2XVU A;  1E7C A;  4G04 A;  4S1Y A;  1HK2 A;  2BXP A;  1H9Z A;  2I30 A;  5DBY A;  4LUF A;  1HK1 A;  4F5V A;  4LB9 A;  1HK5 A;  4LB2 A;  3UIV A;  1E7E A;  4K71 A;  3TDL A;  1KXP D;  4Z69 A;  4HGM B;  3A73 A;  1AO6 A;  1BKE A;  2XW1 A;  4N0U D;  2VDB A;  4J2V A;  1TF0 A;  4HGK A;  4K2C A;  5FUO A;  5GHK A;  2BXG A;  5HOZ A;  3LU8 A;  2BXQ A; 
#chains in the Genus database with same CATH topology
 4D7X A;  4ZBR A;  4DHX B;  2E0Y A;  4GDX A;  2XVW A;  1HK4 A;  3KIK A;  5GIP A;  2YDF A;  3VQI A;  4F5U A;  1H5W A;  2LQI A;  4I9O A;  2BXB A;  2V36 A;  3G9K D;  3WHR A;  2KBZ A;  1E7A A;  3ECP A;  2DBX A;  2NNW A;  1MUS A;  2K0N A;  4G01 A;  1NT2 B;  2EFD A;  5BPK A;  5ID7 A;  2Z8K A;  5D7G A;  3V03 A;  1GNJ A;  3B9L A;  2DBW A;  2DYM A;  4EMX A;  3FWC C;  5IIX A;  3NVM A;  4F5S A;  1MUH A;  3LU6 A;  4L9Q A;  3V08 A;  2BX8 A;  2BXN A;  4MBE C;  1E7H A;  4OTU A;  4DM0 A;  4IW2 A;  2BXI A;  1MIV A;  4OT2 A;  2GUT A;  4FK5 B;  1N5U A;  1J78 A;  3JRY A;  3MHS B;  3NVI A;  2JUH A;  3V09 A;  2LOQ A;  2XW0 A;  3NVK A;  5IIU A;  1J7E A;  2EFC A;  2BXL A;  2EFH A;  5IFO A;  3LU7 A;  4BY9 C;  2BXH A;  1MA9 A;  4N0F D;  1VZS A;  4N3Z A;  1E7G A;  4FIP B;  4NAW B;  3WHQ A;  2NQO A;  2VUE A;  4E99 A;  3H3A A;  1HA2 A;  5IJF A;  4TQ0 A;  4TQ1 A;  1HK3 A;  5ID9 A;  2BXK A;  1MIY A;  1BJ5 A;  1KDX A;  4LA0 A;  4GDK B;  1O9X A;  2VUF A;  4LUH A;  2QHB A;  2I2Z A;  1E7F A;  3FWB C;  2BXO A;  4ZC6 A;  4ZBQ A;  1IJG A;  2BXE A;  1GNI A;  5B5T A;  4L9K A;  1LOT A;  4C31 B;  5GIO A;  2QM6 A;  1LNS A;  2LXT A;  1E7B A;  3H37 A;  1MM8 A;  2LXS A;  1TXU A;  3JQZ A;  3SQJ A;  3CX9 A;  2XVQ A;  3SIV B;  3SIU B;  3B9M A;  5IJ5 A;  2BXA A;  1BM0 A;  4ZCG A;  4G03 A;  4IW1 A;  4WA6 B;  2E0X A;  2LQH A;  1E7I A;  2XSI A;  4OR0 A;  4GDL B;  4ZBK A;  1SB0 A;  2Z8I A;  1UOR A;  2BXM A;  2DBU A;  5DQF A;  3M99 C;  1KW2 A;  2EFE A;  4L8U A;  3WHS A;  5IJE A;  4BKE A;  2BXF A;  4PO0 A;  4JK4 A;  4F5T A;  3PLA A;  1E78 A;  3GA9 L;  2OZB B;  3BPJ A;  5IIH A;  2BXC A;  2XVV A;  2BXD A;  4M70 B;  4W4U B;  2XVU A;  1E7C A;  4G04 A;  2CKX A;  4S1Y A;  1HK2 A;  2BXP A;  1H9Z A;  1MIW A;  3KJL A;  2I30 A;  5DBY A;  4LUF A;  4GG2 A;  1HK1 A;  2OT3 A;  1JNB A;  3MHH B;  4F5V A;  4LB9 A;  1FOU A;  3A75 A;  2KWF A;  4OTT A;  1HK5 A;  4LB2 A;  3UIV A;  1E7E A;  4ZUX V;  2XMO A;  4K71 A;  3TDL A;  4Z9O A;  1KXP D;  2ROH A;  4Z69 A;  2DG5 A;  4HGM B;  4FJC B;  3A73 A;  1AO6 A;  1BKE A;  2AJE A;  3FNM A;  2XW1 A;  3ICX A;  4N0U D;  1VFI A;  3GQU A;  2VDB A;  3W1S A;  2AGH B;  4J2V A;  1TF0 A;  4HGK A;  4K2C A;  3GQX A;  5GIN A;  5FUO A;  5GHK A;  2BXG A;  2QMC A;  5HOZ A;  3NMU A;  3LU8 A;  2Z8J A;  2BXQ A;  2DYO A; 
#chains in the Genus database with same CATH homology
 4ZBR A;  4DHX B;  2E0Y A;  4GDX A;  2XVW A;  1HK4 A;  3KIK A;  5GIP A;  2YDF A;  3VQI A;  4F5U A;  1H5W A;  2BXB A;  2V36 A;  3G9K D;  3WHR A;  2KBZ A;  1E7A A;  2DBX A;  2NNW A;  4G01 A;  1NT2 B;  2EFD A;  5BPK A;  5ID7 A;  2Z8K A;  5D7G A;  3V03 A;  1GNJ A;  3B9L A;  2DBW A;  2DYM A;  4EMX A;  3FWC C;  5IIX A;  3NVM A;  4F5S A;  3LU6 A;  4L9Q A;  3V08 A;  2BX8 A;  2BXN A;  4MBE C;  1E7H A;  4OTU A;  4IW2 A;  2BXI A;  1MIV A;  4OT2 A;  4FK5 B;  1N5U A;  1J78 A;  3JRY A;  3MHS B;  3NVI A;  2JUH A;  3V09 A;  2LOQ A;  2XW0 A;  3NVK A;  5IIU A;  1J7E A;  2EFC A;  2BXL A;  2EFH A;  5IFO A;  3LU7 A;  4BY9 C;  2BXH A;  1MA9 A;  4N0F D;  1VZS A;  4N3Z A;  1E7G A;  4FIP B;  4NAW B;  3WHQ A;  2NQO A;  2VUE A;  4E99 A;  3H3A A;  1HA2 A;  5IJF A;  4TQ0 A;  4TQ1 A;  1HK3 A;  5ID9 A;  2BXK A;  1MIY A;  1BJ5 A;  4LA0 A;  4GDK B;  1O9X A;  2VUF A;  4LUH A;  2QHB A;  2I2Z A;  1E7F A;  3FWB C;  2BXO A;  4ZC6 A;  4ZBQ A;  1IJG A;  2BXE A;  1GNI A;  5B5T A;  4L9K A;  1LOT A;  4C31 B;  5GIO A;  2QM6 A;  1LNS A;  1E7B A;  3H37 A;  1TXU A;  3JQZ A;  3SQJ A;  3CX9 A;  2XVQ A;  3SIV B;  3SIU B;  3B9M A;  5IJ5 A;  2BXA A;  1BM0 A;  4ZCG A;  4G03 A;  4IW1 A;  4WA6 B;  2E0X A;  2XSI A;  1E7I A;  4OR0 A;  4GDL B;  4ZBK A;  2Z8I A;  1UOR A;  2BXM A;  2DBU A;  5DQF A;  3M99 C;  1KW2 A;  2EFE A;  4L8U A;  3WHS A;  5IJE A;  4BKE A;  2BXF A;  4PO0 A;  4JK4 A;  4F5T A;  3PLA A;  1E78 A;  3GA9 L;  2OZB B;  5IIH A;  2BXC A;  2XVV A;  2BXD A;  4M70 B;  4W4U B;  2XVU A;  1E7C A;  4G04 A;  2CKX A;  4S1Y A;  1HK2 A;  2BXP A;  1H9Z A;  1MIW A;  3KJL A;  2I30 A;  5DBY A;  4LUF A;  4GG2 A;  1HK1 A;  2OT3 A;  1JNB A;  3MHH B;  4F5V A;  4LB9 A;  1FOU A;  3A75 A;  4OTT A;  1HK5 A;  4LB2 A;  3UIV A;  1E7E A;  4ZUX V;  2XMO A;  4K71 A;  3TDL A;  4Z9O A;  1KXP D;  2ROH A;  4Z69 A;  2DG5 A;  4HGM B;  4FJC B;  3A73 A;  1AO6 A;  1BKE A;  2AJE A;  3FNM A;  2XW1 A;  3ICX A;  4N0U D;  1VFI A;  3GQU A;  2VDB A;  3W1S A;  4J2V A;  1TF0 A;  4HGK A;  4K2C A;  3GQX A;  5GIN A;  5FUO A;  5GHK A;  2BXG A;  2QMC A;  5HOZ A;  3NMU A;  3LU8 A;  2Z8J A;  2BXQ A;  2DYO A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...