4LB9A

X-ray study of human serum albumin complexed with etoposide
Total Genus 219
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
219
sequence length
583
structure length
583
Chain Sequence
AHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of several clinically important oncology drugs in complex with human serum albumin.
pubmed doi rcsb
molecule keywords SERUM ALBUMIN
molecule tags Transport protein
total genus 219
structure length 583
sequence length 583
ec nomenclature
pdb deposition date 2013-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 4lb9A05
2BX8A 1HK1A 4OR0A 2BXIA 2BXQA 5IJ5A 3V03A 1E78A 2BXPA 3JQZA 2XW0A 1KW2A 1AO6A 4Z69A 4PO0A 1TF0A 4LA0A 3B9MA 1HA2A 2VUEA 4F5VA 1GNIA 2BXKA 2BXDA 2XSIA 2VUFA 1BM0A 4OT2A 1HK3A 4L9QA 1E7HA 5HOZA 1UORA 5DBYA 4E99A 4K2CA 5FUOA 4G04A 4JK4A 1MA9A 4IW2A 4BKEA 5IIUA 2I2ZA 2VDBA 5IFOA 2BXMA 2XVUA 4ZBRA 1E7FA 4L9KA 5GHKA 1KXPD 1E7GA 1HK5A 1BKEA 2BXFA 2BXEA 4F5UA 5IJFA 3B9LA 3SQJA 1E7IA 1HK2A 4G03A 3A73A 5DQFA 2BXLA 2BXGA 4IW1A 4LUFA 1J78A 3JRYA 4F5SA 5IIHA 2BXNA 4LUHA 3TDLA 5ID9A 3V09A 1BJ5A 4K71A 2BXAA 3LU7A 4S1YA 3V08A 1GNJA 1J7EA 4ZBQA 2XVVA 2BXOA 4L8UA 4HGMB 4N0UD 3UIVA 1E7EA 2YDFA 5IJEA 3CX9A 4EMXA 5IIXA 2BXBA 3LU8A 1E7CA 2BXHA 3LU6A 2BXCA 4LB9A 1H9ZA 1E7AA 2XW1A 1LOTA 4N0FD 5ID7A 1E7BA 1HK4A 1N5UA 4LB2A 2I30A 4F5TA 1O9XA 2XVWA 2XVQA 4HGKA 4J2VA
chains in the Genus database with same CATH superfamily
2QMCA 3VQIA 2BX8A 2OZBB 4ZC6A 1HK1A 4N3ZA 4OR0A 4TQ1A 4C31B 2BXIA 2BXQA 2E0XA 5IJ5A 1E78A 3V03A 4WA6B 2BXPA 1TXUA 4FJCB 3JQZA 2XW0A 1KW2A 2DG5A 4M70B 1AO6A 4Z69A 4PO0A 3FWCC 1MIVA 3FWBC 2Z8JA 1TF0A 2EFCA 4LA0A 3B9MA 1HA2A 2V36A 2VUEA 3WHQA 4F5VA 1GNIA 2JUHA 2BXKA 2BXDA 2EFDA 3ICXA 1MM8A 2XSIA 2VUFA 1BM0A 2EFHA 1MIYA 1HK3A 4L9QA 4OT2A 1E7HA 1SB0A 5HOZA 3MHSB 2LXTA 1UORA 4GDLB 4MBEC 3NVMA 4K2CA 5DBYA 4E99A 3GQUA 4ZBKA 4G01A 5GINA 5FUOA 4G04A 4JK4A 1FOUA 1MA9A 3PLAA 4IW2A 4BKEA 5IIUA 2I2ZA 4GG2A 2VDBA 2ROHA 1LNSA 5IFOA 2BXMA 2XVUA 2DYMA 2GUTA 4ZBRA 2OT3A 1E7FA 2QM6A 4L9KA 5D7GA 5GHKA 3SIVB 1KXPD 1E7GA 3GA9L 4DHXB 1HK5A 4OTTA 3BPJA 1BKEA 2BXFA 2BXEA 4F5UA 5IJFA 3WHSA 4Z9OA 2AJEA 3B9LA 3SQJA 3H3AA 2QHBA 4W4UB 5GIPA 1E7IA 1HK2A 4G03A 3W1SA 4ZUXV 3A73A 2K0NA 2BXLA 3FNMA 3H37A 5DQFA 4GDKB 3SIUB 2BXGA 1MUHA 4IW1A 1NT2B 1J78A 4LUFA 3JRYA 3NVKA 2DYOA 4F5SA 2BXNA 3GQXA 4LUHA 3TDLA 3WHRA 5IIHA 5ID9A 2E0YA 2EFEA 4FIPB 3V09A 1BJ5A 3KJLA 4NAWB 4K71A 2BXAA 3LU7A 4TQ0A 1H5WA 2XMOA 1JNBA 4S1YA 3V08A 1MIWA 1GNJA 1J7EA 4OTUA 3G9KD 1VZSA 4ZCGA 4ZBQA 2CKXA 2XVVA 2BXOA 4BY9C 3NMUA 4DM0A 3A75A 2DBXA 4L8UA 1VFIA 2Z8KA 4HGMB 4N0UD 3UIVA 2LXSA 5GIOA 3ECPA 5BPKA 4D7XA 3M99C 1E7EA 2YDFA 2Z8IA 5IJEA 3CX9A 4EMXA 3NVIA 2LOQA 5IIXA 2BXBA 2AGHB 3LU8A 1E7CA 3KIKA 2BXHA 2DBWA 2KWFA 3LU6A 2LQHA 1KDXA 2BXCA 4LB9A 1H9ZA 1E7AA 2XW1A 1LOTA 4N0FD 3MHHB 5ID7A 2LQIA 2KBZA 1E7BA 1HK4A 1N5UA 4GDXA 4LB2A 2I30A 4I9OA 4F5TA 4FK5B 2NQOA 2DBUA 2NNWA 1O9XA 2XVWA 2XVQA 4HGKA 5B5TA 1IJGA 1MUSA 4J2VA
chains in the Genus database with same CATH topology
2QMCA 3VQIA 2BX8A 2OZBB 4ZC6A 1HK1A 4N3ZA 4OR0A 4TQ1A 4C31B 2BXIA 2BXQA 2E0XA 5IJ5A 1E78A 3V03A 4WA6B 2BXPA 1TXUA 4FJCB 3JQZA 2XW0A 1KW2A 2DG5A 4M70B 1AO6A 4Z69A 4PO0A 3FWCC 1MIVA 3FWBC 2Z8JA 1TF0A 2EFCA 4LA0A 3B9MA 1HA2A 2V36A 2VUEA 3WHQA 4F5VA 1GNIA 2JUHA 2BXKA 2BXDA 2EFDA 3ICXA 2XSIA 2VUFA 1BM0A 2EFHA 1MIYA 1HK3A 4L9QA 4OT2A 1E7HA 5HOZA 3MHSB 1UORA 4GDLB 4MBEC 3NVMA 4K2CA 5DBYA 4E99A 3GQUA 4ZBKA 4G01A 5GINA 5FUOA 4G04A 4JK4A 1FOUA 1MA9A 3PLAA 4IW2A 4BKEA 5IIUA 2I2ZA 4GG2A 2VDBA 2ROHA 1LNSA 5IFOA 2BXMA 2XVUA 2DYMA 4ZBRA 2OT3A 1E7FA 2QM6A 4L9KA 5D7GA 5GHKA 3SIVB 1KXPD 1E7GA 3GA9L 4DHXB 1HK5A 4OTTA 1BKEA 2BXFA 2BXEA 4F5UA 5IJFA 3WHSA 4Z9OA 2AJEA 3B9LA 3SQJA 3H3AA 2QHBA 4W4UB 5GIPA 1E7IA 1HK2A 4G03A 3W1SA 4ZUXV 3A73A 3FNMA 2BXLA 3H37A 5DQFA 3SIUB 4GDKB 2BXGA 4IW1A 1NT2B 1J78A 4LUFA 3JRYA 3NVKA 2DYOA 4F5SA 2BXNA 3GQXA 4LUHA 3TDLA 3WHRA 5IIHA 5ID9A 2E0YA 2EFEA 4FIPB 3V09A 1BJ5A 3KJLA 4NAWB 4K71A 2BXAA 3LU7A 4TQ0A 1H5WA 2XMOA 1JNBA 4S1YA 3V08A 1MIWA 1GNJA 1J7EA 4OTUA 3G9KD 1VZSA 4ZCGA 4ZBQA 2CKXA 2XVVA 2BXOA 4BY9C 3NMUA 3A75A 2DBXA 4L8UA 1VFIA 2Z8KA 4HGMB 4N0UD 3UIVA 5GIOA 5BPKA 3M99C 1E7EA 2YDFA 2Z8IA 5IJEA 3CX9A 4EMXA 3NVIA 2LOQA 5IIXA 2BXBA 3LU8A 1E7CA 3KIKA 2BXHA 2DBWA 3LU6A 2BXCA 4LB9A 1H9ZA 1E7AA 2XW1A 1LOTA 4N0FD 3MHHB 5ID7A 2KBZA 1E7BA 1HK4A 1N5UA 4GDXA 4LB2A 2I30A 4F5TA 4FK5B 2NQOA 2DBUA 2NNWA 1O9XA 2XVWA 2XVQA 4HGKA 5B5TA 1IJGA 4J2VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BX8 A;  1HK1 A;  4OR0 A;  2BXI A;  2BXQ A;  5IJ5 A;  3V03 A;  1E78 A;  2BXP A;  3JQZ A;  2XW0 A;  1KW2 A;  1AO6 A;  4Z69 A;  4PO0 A;  1TF0 A;  4LA0 A;  3B9M A;  1HA2 A;  2VUE A;  4F5V A;  1GNI A;  2BXK A;  2BXD A;  2XSI A;  2VUF A;  1BM0 A;  4OT2 A;  1HK3 A;  4L9Q A;  1E7H A;  5HOZ A;  1UOR A;  5DBY A;  4E99 A;  4K2C A;  5FUO A;  4G04 A;  4JK4 A;  1MA9 A;  4IW2 A;  4BKE A;  5IIU A;  2I2Z A;  2VDB A;  5IFO A;  2BXM A;  2XVU A;  4ZBR A;  1E7F A;  4L9K A;  5GHK A;  1KXP D;  1E7G A;  1HK5 A;  1BKE A;  2BXF A;  2BXE A;  4F5U A;  5IJF A;  3B9L A;  3SQJ A;  1E7I A;  1HK2 A;  4G03 A;  3A73 A;  5DQF A;  2BXL A;  2BXG A;  4IW1 A;  4LUF A;  1J78 A;  3JRY A;  4F5S A;  5IIH A;  2BXN A;  4LUH A;  3TDL A;  5ID9 A;  3V09 A;  1BJ5 A;  4K71 A;  2BXA A;  3LU7 A;  4S1Y A;  3V08 A;  1GNJ A;  1J7E A;  4ZBQ A;  2XVV A;  2BXO A;  4L8U A;  4HGM B;  4N0U D;  3UIV A;  1E7E A;  2YDF A;  5IJE A;  3CX9 A;  4EMX A;  5IIX A;  2BXB A;  3LU8 A;  1E7C A;  2BXH A;  3LU6 A;  2BXC A;  4LB9 A;  1H9Z A;  1E7A A;  2XW1 A;  1LOT A;  4N0F D;  5ID7 A;  1E7B A;  1HK4 A;  1N5U A;  4LB2 A;  2I30 A;  4F5T A;  1O9X A;  2XVW A;  2XVQ A;  4HGK A;  4J2V A; 
#chains in the Genus database with same CATH topology
 2QMC A;  3VQI A;  2BX8 A;  2OZB B;  4ZC6 A;  1HK1 A;  4N3Z A;  4OR0 A;  4TQ1 A;  4C31 B;  2BXI A;  2BXQ A;  2E0X A;  5IJ5 A;  1E78 A;  3V03 A;  4WA6 B;  2BXP A;  1TXU A;  4FJC B;  3JQZ A;  2XW0 A;  1KW2 A;  2DG5 A;  4M70 B;  1AO6 A;  4Z69 A;  4PO0 A;  3FWC C;  1MIV A;  3FWB C;  2Z8J A;  1TF0 A;  2EFC A;  4LA0 A;  3B9M A;  1HA2 A;  2V36 A;  2VUE A;  3WHQ A;  4F5V A;  1GNI A;  2JUH A;  2BXK A;  2BXD A;  2EFD A;  3ICX A;  1MM8 A;  2XSI A;  2VUF A;  1BM0 A;  2EFH A;  1MIY A;  1HK3 A;  4L9Q A;  4OT2 A;  1E7H A;  1SB0 A;  5HOZ A;  3MHS B;  2LXT A;  1UOR A;  4GDL B;  4MBE C;  3NVM A;  4K2C A;  5DBY A;  4E99 A;  3GQU A;  4ZBK A;  4G01 A;  5GIN A;  5FUO A;  4G04 A;  4JK4 A;  1FOU A;  1MA9 A;  3PLA A;  4IW2 A;  4BKE A;  5IIU A;  2I2Z A;  4GG2 A;  2VDB A;  2ROH A;  1LNS A;  5IFO A;  2BXM A;  2XVU A;  2DYM A;  2GUT A;  4ZBR A;  2OT3 A;  1E7F A;  2QM6 A;  4L9K A;  5D7G A;  5GHK A;  3SIV B;  1KXP D;  1E7G A;  3GA9 L;  4DHX B;  1HK5 A;  4OTT A;  3BPJ A;  1BKE A;  2BXF A;  2BXE A;  4F5U A;  5IJF A;  3WHS A;  4Z9O A;  2AJE A;  3B9L A;  3SQJ A;  3H3A A;  2QHB A;  4W4U B;  5GIP A;  1E7I A;  1HK2 A;  4G03 A;  3W1S A;  4ZUX V;  3A73 A;  2K0N A;  2BXL A;  3FNM A;  3H37 A;  5DQF A;  4GDK B;  3SIU B;  2BXG A;  1MUH A;  4IW1 A;  1NT2 B;  1J78 A;  4LUF A;  3JRY A;  3NVK A;  2DYO A;  4F5S A;  2BXN A;  3GQX A;  4LUH A;  3TDL A;  3WHR A;  5IIH A;  5ID9 A;  2E0Y A;  2EFE A;  4FIP B;  3V09 A;  1BJ5 A;  3KJL A;  4NAW B;  4K71 A;  2BXA A;  3LU7 A;  4TQ0 A;  1H5W A;  2XMO A;  1JNB A;  4S1Y A;  3V08 A;  1MIW A;  1GNJ A;  1J7E A;  4OTU A;  3G9K D;  1VZS A;  4ZCG A;  4ZBQ A;  2CKX A;  2XVV A;  2BXO A;  4BY9 C;  3NMU A;  4DM0 A;  3A75 A;  2DBX A;  4L8U A;  1VFI A;  2Z8K A;  4HGM B;  4N0U D;  3UIV A;  2LXS A;  5GIO A;  3ECP A;  5BPK A;  4D7X A;  3M99 C;  1E7E A;  2YDF A;  2Z8I A;  5IJE A;  3CX9 A;  4EMX A;  3NVI A;  2LOQ A;  5IIX A;  2BXB A;  2AGH B;  3LU8 A;  1E7C A;  3KIK A;  2BXH A;  2DBW A;  2KWF A;  3LU6 A;  2LQH A;  1KDX A;  2BXC A;  4LB9 A;  1H9Z A;  1E7A A;  2XW1 A;  1LOT A;  4N0F D;  3MHH B;  5ID7 A;  2LQI A;  2KBZ A;  1E7B A;  1HK4 A;  1N5U A;  4GDX A;  4LB2 A;  2I30 A;  4I9O A;  4F5T A;  4FK5 B;  2NQO A;  2DBU A;  2NNW A;  1O9X A;  2XVW A;  2XVQ A;  4HGK A;  5B5T A;  1IJG A;  1MUS A;  4J2V A; 
#chains in the Genus database with same CATH homology
 2QMC A;  3VQI A;  2BX8 A;  2OZB B;  4ZC6 A;  1HK1 A;  4N3Z A;  4OR0 A;  4TQ1 A;  4C31 B;  2BXI A;  2BXQ A;  2E0X A;  5IJ5 A;  1E78 A;  3V03 A;  4WA6 B;  2BXP A;  1TXU A;  4FJC B;  3JQZ A;  2XW0 A;  1KW2 A;  2DG5 A;  4M70 B;  1AO6 A;  4Z69 A;  4PO0 A;  3FWC C;  1MIV A;  3FWB C;  2Z8J A;  1TF0 A;  2EFC A;  4LA0 A;  3B9M A;  1HA2 A;  2V36 A;  2VUE A;  3WHQ A;  4F5V A;  1GNI A;  2JUH A;  2BXK A;  2BXD A;  2EFD A;  3ICX A;  2XSI A;  2VUF A;  1BM0 A;  2EFH A;  1MIY A;  1HK3 A;  4L9Q A;  4OT2 A;  1E7H A;  5HOZ A;  3MHS B;  1UOR A;  4GDL B;  4MBE C;  3NVM A;  4K2C A;  5DBY A;  4E99 A;  3GQU A;  4ZBK A;  4G01 A;  5GIN A;  5FUO A;  4G04 A;  4JK4 A;  1FOU A;  1MA9 A;  3PLA A;  4IW2 A;  4BKE A;  5IIU A;  2I2Z A;  4GG2 A;  2VDB A;  2ROH A;  1LNS A;  5IFO A;  2BXM A;  2XVU A;  2DYM A;  4ZBR A;  2OT3 A;  1E7F A;  2QM6 A;  4L9K A;  5D7G A;  5GHK A;  3SIV B;  1KXP D;  1E7G A;  3GA9 L;  4DHX B;  1HK5 A;  4OTT A;  1BKE A;  2BXF A;  2BXE A;  4F5U A;  5IJF A;  3WHS A;  4Z9O A;  2AJE A;  3B9L A;  3SQJ A;  3H3A A;  2QHB A;  4W4U B;  5GIP A;  1E7I A;  1HK2 A;  4G03 A;  3W1S A;  4ZUX V;  3A73 A;  3FNM A;  2BXL A;  3H37 A;  5DQF A;  3SIU B;  4GDK B;  2BXG A;  4IW1 A;  1NT2 B;  1J78 A;  4LUF A;  3JRY A;  3NVK A;  2DYO A;  4F5S A;  2BXN A;  3GQX A;  4LUH A;  3TDL A;  3WHR A;  5IIH A;  5ID9 A;  2E0Y A;  2EFE A;  4FIP B;  3V09 A;  1BJ5 A;  3KJL A;  4NAW B;  4K71 A;  2BXA A;  3LU7 A;  4TQ0 A;  1H5W A;  2XMO A;  1JNB A;  4S1Y A;  3V08 A;  1MIW A;  1GNJ A;  1J7E A;  4OTU A;  3G9K D;  1VZS A;  4ZCG A;  4ZBQ A;  2CKX A;  2XVV A;  2BXO A;  4BY9 C;  3NMU A;  3A75 A;  2DBX A;  4L8U A;  1VFI A;  2Z8K A;  4HGM B;  4N0U D;  3UIV A;  5GIO A;  5BPK A;  3M99 C;  1E7E A;  2YDF A;  2Z8I A;  5IJE A;  3CX9 A;  4EMX A;  3NVI A;  2LOQ A;  5IIX A;  2BXB A;  3LU8 A;  1E7C A;  3KIK A;  2BXH A;  2DBW A;  3LU6 A;  2BXC A;  4LB9 A;  1H9Z A;  1E7A A;  2XW1 A;  1LOT A;  4N0F D;  3MHH B;  5ID7 A;  2KBZ A;  1E7B A;  1HK4 A;  1N5U A;  4GDX A;  4LB2 A;  2I30 A;  4F5T A;  4FK5 B;  2NQO A;  2DBU A;  2NNW A;  1O9X A;  2XVW A;  2XVQ A;  4HGK A;  5B5T A;  1IJG A;  4J2V A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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