5BPKA

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
348
structure length
348
Chain Sequence
ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
rcsb
molecule tags Hydrolase
source organism Helicobacter pylori 26695
molecule keywords Gamma-glutamyltranspeptidase (Ggt)
total genus 107
structure length 348
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.130 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5bpkA02
2DBUA 4GG2A 2QM6A 4OTUA 2E0YA 5BPKA 3FNMA 4ZC6A 4GDXA 2Z8IA 2NQOA 2DG5A 2Z8JA 3WHRA 3WHSA 2E0XA 2QMCA 2DBXA 4ZCGA 5B5TA 2DBWA 2V36A 3WHQA 4OTTA 4ZBKA 2Z8KA 3A75A 4Z9OA
chains in the Genus database with same CATH superfamily
2BXNA 1KDXA 2I2ZA 2XVVA 4L9KA 4G01A 4HGMB 4OTUA 3TDLA 1O9XA 4FJCB 4OT2A 2XVUA 3UIVA 4J2VA 3B9MA 1GNJA 1NT2B 1TF0A 3NVKA 1MA9A 2BXIA 5DQFA 3LU8A 2BXMA 3LU7A 3WHRA 4GDLB 4I9OA 4ZBRA 5GIPA 4Z69A 3GA9L 4N3ZA 1UORA 2DBXA 3KJLA 1MUHA 3V09A 5B5TA 2DBWA 2XVQA 4LUHA 4LB9A 2BX8A 2XMOA 2BXHA 2BXGA 2EFHA 2LQHA 2BXOA 3CX9A 2LXSA 4N0UD 5IIUA 1AO6A 4BY9C 4DHXB 5IJFA 2EFDA 2KWFA 2JUHA 3FWCC 3GQUA 1SB0A 3JQZA 4FK5B 4S1YA 4HGKA 4G03A 2KBZA 2BXLA 4EMXA 4FIPB 4GG2A 5IFOA 2OT3A 2E0YA 4BKEA 3NMUA 1MUSA 2YDFA 3SQJA 3BPJA 4K71A 4ZC6A 4GDXA 1E7GA 2BXQA 3G9KD 1HK5A 4K2CA 2Z8JA 1E7AA 2DYMA 1H5WA 2ROHA 5IIHA 2GUTA 4ZCGA 3MHSB 1J78A 1E7CA 1MIWA 5DBYA 1JNBA 5IJEA 4LUFA 1LOTA 2LXTA 3M99C 4ZBQA 5HOZA 1VFIA 3PLAA 5GINA 5IJ5A 1MM8A 4N0FD 3WHQA 1BKEA 3LU6A 2Z8KA 1HK3A 5D7GA 2VUEA 2XW0A 4W4UB 5GHKA 2AJEA 3SIUB 2EFEA 2K0NA 3V08A 2BXFA 3MHHB 1HK4A 2DBUA 2QM6A 1TXUA 1E7EA 2BXBA 4OR0A 5BPKA 1MIVA 3GQXA 4MBEC 1MIYA 3FNMA 3A73A 1LNSA 2XVWA 4D7XA 1IJGA 3W1SA 4TQ1A 1BM0A 2BXCA 3JRYA 1J7EA 1E7HA 3WHSA 4TQ0A 1E7FA 1GNIA 2E0XA 1FOUA 4G04A 1BJ5A 2I30A 3KIKA 3H37A 2NNWA 2XW1A 1E7BA 4IW1A 5GIOA 4DM0A 3H3AA 4OTTA 3B9LA 4F5SA 4ZUXV 3A75A 4JK4A 4WA6B 3NVMA 1HK1A 5FUOA 1E78A 3SIVB 3FWBC 4F5TA 3ECPA 2OZBB 3NVIA 3ICXA 3V03A 4GDKB 4F5VA 2LQIA 4F5UA 3VQIA 1E7IA 2EFCA 4E99A 2BXDA 2BXAA 2Z8IA 2XSIA 2NQOA 4NAWB 5ID9A 2DG5A 1KW2A 4PO0A 1H9ZA 2DYOA 4M70B 2LOQA 4IW2A 2QMCA 4L8UA 2BXKA 5ID7A 4LB2A 1KXPD 2AGHB 1HA2A 2BXEA 4L9QA 2CKXA 1VZSA 2BXPA 2V36A 1N5UA 2VDBA 1HK2A 2QHBA 2VUFA 4ZBKA 4C31B 5IIXA 4LA0A 4Z9OA
chains in the Genus database with same CATH topology
2BXNA 2I2ZA 2XVVA 4L9KA 4G01A 4HGMB 4OTUA 3TDLA 1O9XA 4FJCB 4OT2A 2XVUA 3UIVA 4J2VA 3B9MA 1GNJA 1NT2B 1TF0A 3NVKA 1MA9A 2BXIA 5DQFA 3LU8A 2BXMA 3LU7A 3WHRA 4GDLB 5GIPA 4ZBRA 4Z69A 3GA9L 4N3ZA 1UORA 2DBXA 3KJLA 3V09A 5B5TA 2DBWA 2XVQA 4LUHA 4LB9A 2BX8A 2XMOA 2BXHA 2BXGA 2EFHA 3CX9A 2BXOA 4N0UD 1AO6A 4BY9C 5IIUA 4DHXB 5IJFA 2EFDA 2JUHA 3FWCC 3GQUA 3JQZA 4FK5B 4S1YA 4HGKA 4G03A 2KBZA 2BXLA 4EMXA 4FIPB 4GG2A 5IFOA 2OT3A 2E0YA 4BKEA 3NMUA 2YDFA 3SQJA 4K71A 4ZC6A 4GDXA 1E7GA 2BXQA 3G9KD 1HK5A 4K2CA 2Z8JA 1E7AA 2DYMA 1H5WA 2ROHA 5IIHA 4ZCGA 3MHSB 1J78A 1E7CA 1MIWA 5DBYA 1JNBA 5IJEA 4LUFA 1LOTA 3M99C 4ZBQA 5HOZA 1VFIA 3PLAA 5GINA 5IJ5A 4N0FD 3WHQA 1BKEA 3LU6A 2Z8KA 1HK3A 5D7GA 2VUEA 2XW0A 4W4UB 5GHKA 2AJEA 3SIUB 2EFEA 3V08A 2BXFA 3MHHB 1HK4A 2DBUA 2QM6A 1TXUA 1E7EA 2BXBA 4OR0A 5BPKA 1MIVA 3GQXA 4MBEC 1MIYA 3FNMA 3A73A 1LNSA 2XVWA 1IJGA 3W1SA 4TQ1A 1BM0A 2BXCA 3JRYA 1J7EA 1E7HA 3WHSA 4TQ0A 1E7FA 1GNIA 2E0XA 1FOUA 4G04A 1BJ5A 2I30A 3KIKA 3H37A 2NNWA 2XW1A 1E7BA 4IW1A 5GIOA 3H3AA 4OTTA 3B9LA 4F5SA 4ZUXV 3A75A 4JK4A 4WA6B 3NVMA 1HK1A 5FUOA 1E78A 3SIVB 3FWBC 4F5TA 2OZBB 3NVIA 3ICXA 3V03A 4GDKB 4F5VA 4F5UA 3VQIA 1E7IA 2EFCA 4E99A 2BXDA 2BXAA 2Z8IA 2XSIA 2NQOA 4NAWB 5ID9A 2DG5A 1KW2A 4PO0A 1H9ZA 2DYOA 4M70B 2LOQA 4IW2A 2QMCA 4L8UA 2BXKA 5ID7A 4LB2A 1KXPD 1HA2A 2BXEA 4L9QA 2CKXA 1VZSA 2BXPA 2V36A 1N5UA 2VDBA 1HK2A 2QHBA 2VUFA 4ZBKA 4C31B 5IIXA 4LA0A 4Z9OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DBU A;  4GG2 A;  2QM6 A;  4OTU A;  2E0Y A;  5BPK A;  3FNM A;  4ZC6 A;  4GDX A;  2Z8I A;  2NQO A;  2DG5 A;  2Z8J A;  3WHR A;  3WHS A;  2E0X A;  2QMC A;  2DBX A;  4ZCG A;  5B5T A;  2DBW A;  2V36 A;  3WHQ A;  4OTT A;  4ZBK A;  2Z8K A;  3A75 A;  4Z9O A; 
#chains in the Genus database with same CATH topology
 2BXN A;  1KDX A;  2I2Z A;  2XVV A;  4L9K A;  4G01 A;  4HGM B;  4OTU A;  3TDL A;  1O9X A;  4FJC B;  4OT2 A;  2XVU A;  3UIV A;  4J2V A;  3B9M A;  1GNJ A;  1NT2 B;  1TF0 A;  3NVK A;  1MA9 A;  2BXI A;  5DQF A;  3LU8 A;  2BXM A;  3LU7 A;  3WHR A;  4GDL B;  4I9O A;  4ZBR A;  5GIP A;  4Z69 A;  3GA9 L;  4N3Z A;  1UOR A;  2DBX A;  3KJL A;  1MUH A;  3V09 A;  5B5T A;  2DBW A;  2XVQ A;  4LUH A;  4LB9 A;  2BX8 A;  2XMO A;  2BXH A;  2BXG A;  2EFH A;  2LQH A;  2BXO A;  3CX9 A;  2LXS A;  4N0U D;  5IIU A;  1AO6 A;  4BY9 C;  4DHX B;  5IJF A;  2EFD A;  2KWF A;  2JUH A;  3FWC C;  3GQU A;  1SB0 A;  3JQZ A;  4FK5 B;  4S1Y A;  4HGK A;  4G03 A;  2KBZ A;  2BXL A;  4EMX A;  4FIP B;  4GG2 A;  5IFO A;  2OT3 A;  2E0Y A;  4BKE A;  3NMU A;  1MUS A;  2YDF A;  3SQJ A;  3BPJ A;  4K71 A;  4ZC6 A;  4GDX A;  1E7G A;  2BXQ A;  3G9K D;  1HK5 A;  4K2C A;  2Z8J A;  1E7A A;  2DYM A;  1H5W A;  2ROH A;  5IIH A;  2GUT A;  4ZCG A;  3MHS B;  1J78 A;  1E7C A;  1MIW A;  5DBY A;  1JNB A;  5IJE A;  4LUF A;  1LOT A;  2LXT A;  3M99 C;  4ZBQ A;  5HOZ A;  1VFI A;  3PLA A;  5GIN A;  5IJ5 A;  1MM8 A;  4N0F D;  3WHQ A;  1BKE A;  3LU6 A;  2Z8K A;  1HK3 A;  5D7G A;  2VUE A;  2XW0 A;  4W4U B;  5GHK A;  2AJE A;  3SIU B;  2EFE A;  2K0N A;  3V08 A;  2BXF A;  3MHH B;  1HK4 A;  2DBU A;  2QM6 A;  1TXU A;  1E7E A;  2BXB A;  4OR0 A;  5BPK A;  1MIV A;  3GQX A;  4MBE C;  1MIY A;  3FNM A;  3A73 A;  1LNS A;  2XVW A;  4D7X A;  1IJG A;  3W1S A;  4TQ1 A;  1BM0 A;  2BXC A;  3JRY A;  1J7E A;  1E7H A;  3WHS A;  4TQ0 A;  1E7F A;  1GNI A;  2E0X A;  1FOU A;  4G04 A;  1BJ5 A;  2I30 A;  3KIK A;  3H37 A;  2NNW A;  2XW1 A;  1E7B A;  4IW1 A;  5GIO A;  4DM0 A;  3H3A A;  4OTT A;  3B9L A;  4F5S A;  4ZUX V;  3A75 A;  4JK4 A;  4WA6 B;  3NVM A;  1HK1 A;  5FUO A;  1E78 A;  3SIV B;  3FWB C;  4F5T A;  3ECP A;  2OZB B;  3NVI A;  3ICX A;  3V03 A;  4GDK B;  4F5V A;  2LQI A;  4F5U A;  3VQI A;  1E7I A;  2EFC A;  4E99 A;  2BXD A;  2BXA A;  2Z8I A;  2XSI A;  2NQO A;  4NAW B;  5ID9 A;  2DG5 A;  1KW2 A;  4PO0 A;  1H9Z A;  2DYO A;  4M70 B;  2LOQ A;  4IW2 A;  2QMC A;  4L8U A;  2BXK A;  5ID7 A;  4LB2 A;  1KXP D;  2AGH B;  1HA2 A;  2BXE A;  4L9Q A;  2CKX A;  1VZS A;  2BXP A;  2V36 A;  1N5U A;  2VDB A;  1HK2 A;  2QHB A;  2VUF A;  4ZBK A;  4C31 B;  5IIX A;  4LA0 A;  4Z9O A; 
#chains in the Genus database with same CATH homology
 2BXN A;  2I2Z A;  2XVV A;  4L9K A;  4G01 A;  4HGM B;  4OTU A;  3TDL A;  1O9X A;  4FJC B;  4OT2 A;  2XVU A;  3UIV A;  4J2V A;  3B9M A;  1GNJ A;  1NT2 B;  1TF0 A;  3NVK A;  1MA9 A;  2BXI A;  5DQF A;  3LU8 A;  2BXM A;  3LU7 A;  3WHR A;  4GDL B;  5GIP A;  4ZBR A;  4Z69 A;  3GA9 L;  4N3Z A;  1UOR A;  2DBX A;  3KJL A;  3V09 A;  5B5T A;  2DBW A;  2XVQ A;  4LUH A;  4LB9 A;  2BX8 A;  2XMO A;  2BXH A;  2BXG A;  2EFH A;  3CX9 A;  2BXO A;  4N0U D;  1AO6 A;  4BY9 C;  5IIU A;  4DHX B;  5IJF A;  2EFD A;  2JUH A;  3FWC C;  3GQU A;  3JQZ A;  4FK5 B;  4S1Y A;  4HGK A;  4G03 A;  2KBZ A;  2BXL A;  4EMX A;  4FIP B;  4GG2 A;  5IFO A;  2OT3 A;  2E0Y A;  4BKE A;  3NMU A;  2YDF A;  3SQJ A;  4K71 A;  4ZC6 A;  4GDX A;  1E7G A;  2BXQ A;  3G9K D;  1HK5 A;  4K2C A;  2Z8J A;  1E7A A;  2DYM A;  1H5W A;  2ROH A;  5IIH A;  4ZCG A;  3MHS B;  1J78 A;  1E7C A;  1MIW A;  5DBY A;  1JNB A;  5IJE A;  4LUF A;  1LOT A;  3M99 C;  4ZBQ A;  5HOZ A;  1VFI A;  3PLA A;  5GIN A;  5IJ5 A;  4N0F D;  3WHQ A;  1BKE A;  3LU6 A;  2Z8K A;  1HK3 A;  5D7G A;  2VUE A;  2XW0 A;  4W4U B;  5GHK A;  2AJE A;  3SIU B;  2EFE A;  3V08 A;  2BXF A;  3MHH B;  1HK4 A;  2DBU A;  2QM6 A;  1TXU A;  1E7E A;  2BXB A;  4OR0 A;  5BPK A;  1MIV A;  3GQX A;  4MBE C;  1MIY A;  3FNM A;  3A73 A;  1LNS A;  2XVW A;  1IJG A;  3W1S A;  4TQ1 A;  1BM0 A;  2BXC A;  3JRY A;  1J7E A;  1E7H A;  3WHS A;  4TQ0 A;  1E7F A;  1GNI A;  2E0X A;  1FOU A;  4G04 A;  1BJ5 A;  2I30 A;  3KIK A;  3H37 A;  2NNW A;  2XW1 A;  1E7B A;  4IW1 A;  5GIO A;  3H3A A;  4OTT A;  3B9L A;  4F5S A;  4ZUX V;  3A75 A;  4JK4 A;  4WA6 B;  3NVM A;  1HK1 A;  5FUO A;  1E78 A;  3SIV B;  3FWB C;  4F5T A;  2OZB B;  3NVI A;  3ICX A;  3V03 A;  4GDK B;  4F5V A;  4F5U A;  3VQI A;  1E7I A;  2EFC A;  4E99 A;  2BXD A;  2BXA A;  2Z8I A;  2XSI A;  2NQO A;  4NAW B;  5ID9 A;  2DG5 A;  1KW2 A;  4PO0 A;  1H9Z A;  2DYO A;  4M70 B;  2LOQ A;  4IW2 A;  2QMC A;  4L8U A;  2BXK A;  5ID7 A;  4LB2 A;  1KXP D;  1HA2 A;  2BXE A;  4L9Q A;  2CKX A;  1VZS A;  2BXP A;  2V36 A;  1N5U A;  2VDB A;  1HK2 A;  2QHB A;  2VUF A;  4ZBK A;  4C31 B;  5IIX A;  4LA0 A;  4Z9O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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