5BPKA

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
348
structure length
348
Chain Sequence
ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
rcsb
molecule tags Hydrolase
source organism Helicobacter pylori 26695
molecule keywords Gamma-glutamyltranspeptidase (Ggt)
total genus 107
structure length 348
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.130 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5bpkA02
2DG5A 2DBWA 2Z8IA 4ZC6A 5B5TA 2DBUA 2E0XA 3WHRA 4GDXA 4OTUA 2Z8JA 4ZBKA 2V36A 3WHSA 3A75A 2DBXA 4ZCGA 4OTTA 5BPKA 2NQOA 4GG2A 4Z9OA 2QMCA 2QM6A 2Z8KA 2E0YA 3WHQA 3FNMA
chains in the Genus database with same CATH superfamily
2XVVA 4N0UD 2DG5A 4WA6B 2LQIA 4ZUXV 3CX9A 3FWBC 4OT2A 1JNBA 2LOQA 4HGMB 2LQHA 4PO0A 1MUSA 5B5TA 1BM0A 1AO6A 1SB0A 1HK1A 3MHSB 2E0XA 5HOZA 4F5TA 1HK3A 2JUHA 2OT3A 3A73A 2EFDA 4BKEA 5GIPA 2K0NA 2CKXA 1GNIA 1HA2A 2BXCA 2VDBA 2BXMA 1IJGA 3A75A 4K71A 4LA0A 3LU6A 4N3ZA 1E78A 4OTTA 2BXGA 4GDLB 5IJ5A 5D7GA 2XW0A 4HGKA 2BXEA 4DM0A 5IJEA 5GINA 4LB9A 2EFHA 2Z8KA 5IFOA 3WHQA 4OR0A 2ROHA 3FWCC 4I9OA 3LU7A 1HK4A 1N5UA 2XMOA 3B9LA 3NMUA 1E7AA 2Z8IA 2KBZA 5IJFA 2BXFA 2KWFA 3WHRA 1E7EA 1KDXA 4OTUA 3H3AA 1MIWA 2VUEA 1BJ5A 3GQXA 3FNMA 3ICXA 4MBEC 1HK2A 4F5UA 3NVKA 2EFCA 2I30A 4FK5B 5ID7A 2BXBA 2LXSA 2BXHA 2NQOA 2XVWA 4GG2A 4LUFA 1LNSA 3LU8A 1VFIA 4Z9OA 3UIVA 1VZSA 4FJCB 3V03A 3ECPA 2QMCA 2QM6A 4IW1A 1TF0A 1E7IA 1E7BA 2AGHB 3H37A 1GNJA 2DYOA 1HK5A 4N0FD 2BXNA 5GHKA 2BXAA 1H9ZA 3V09A 3GA9L 2DBUA 1J7EA 4JK4A 1MA9A 4L9KA 3TDLA 1FOUA 4ZBRA 4GDXA 2VUFA 2GUTA 2Z8JA 4S1YA 2XW1A 3SIVB 1BKEA 1MIVA 2EFEA 4G03A 4F5SA 3SQJA 4L9QA 2XVQA 4E99A 4IW2A 3BPJA 3JQZA 3M99C 5BPKA 2BXDA 3V08A 1MUHA 4W4UB 2XSIA 3G9KD 2OZBB 4LB2A 3GQUA 4D7XA 3NVIA 2E0YA 5DBYA 1J78A 2BXPA 3MHHB 4K2CA 4BY9C 1O9XA 2DBWA 2NNWA 4TQ1A 1LOTA 2LXTA 4ZC6A 4F5VA 4J2VA 1KXPD 4LUHA 1E7FA 4Z69A 2BXIA 3B9MA 5GIOA 4FIPB 3KIKA 3NVMA 4L8UA 3SIUB 1UORA 1MIYA 1TXUA 4TQ0A 4ZBQA 1NT2B 4ZBKA 2V36A 3KJLA 5FUOA 3WHSA 2I2ZA 2BX8A 3W1SA 2DBXA 5ID9A 4ZCGA 1H5WA 3VQIA 2XVUA 1KW2A 4GDKB 3PLAA 5IIXA 4C31B 5IIUA 2YDFA 5DQFA 2BXQA 2QHBA 4EMXA 2DYMA 1MM8A 4G04A 1E7CA 2AJEA 4G01A 1E7GA 4DHXB 4M70B 5IIHA 2BXKA 2BXOA 3JRYA 2BXLA 4NAWB 1E7HA
chains in the Genus database with same CATH topology
2XVVA 4N0UD 2DG5A 4WA6B 4ZUXV 3CX9A 3FWBC 4OT2A 1JNBA 2LOQA 4HGMB 4PO0A 5B5TA 1BM0A 1AO6A 4F5TA 1HK1A 3MHSB 2E0XA 5HOZA 1HK3A 2JUHA 2OT3A 3A73A 2EFDA 4BKEA 5GIPA 2CKXA 1GNIA 1HA2A 2BXCA 2VDBA 2BXMA 1IJGA 3A75A 4K71A 4LA0A 3LU6A 4N3ZA 1E78A 4OTTA 2BXGA 4GDLB 5IJ5A 5D7GA 2XW0A 4HGKA 2BXEA 5IJEA 5GINA 4LB9A 2EFHA 2Z8KA 5IFOA 3WHQA 4OR0A 2ROHA 3FWCC 3LU7A 1HK4A 1N5UA 2XMOA 3B9LA 3NMUA 1E7AA 2Z8IA 2KBZA 5IJFA 2BXFA 3WHRA 1E7EA 4OTUA 3H3AA 1MIWA 2VUEA 1BJ5A 3GQXA 3FNMA 3ICXA 4MBEC 1HK2A 4F5UA 3NVKA 2EFCA 2I30A 4FK5B 5ID7A 2BXBA 2BXHA 2NQOA 2XVWA 4GG2A 4LUFA 1LNSA 3LU8A 1VFIA 4Z9OA 3UIVA 1VZSA 4FJCB 3V03A 2QMCA 2QM6A 4IW1A 1TF0A 1E7IA 1E7BA 3H37A 1GNJA 2DYOA 1HK5A 4N0FD 2BXNA 5GHKA 2BXAA 1H9ZA 3V09A 3GA9L 2DBUA 1J7EA 4JK4A 1MA9A 4L9KA 3TDLA 1FOUA 4ZBRA 4GDXA 2VUFA 2Z8JA 4S1YA 3SIVB 2XW1A 1BKEA 1MIVA 2EFEA 4G03A 4F5SA 3SQJA 4L9QA 2XVQA 4E99A 4IW2A 3JQZA 3M99C 5BPKA 2BXDA 3V08A 4W4UB 2XSIA 3G9KD 2OZBB 4LB2A 3GQUA 3NVIA 2E0YA 5DBYA 1J78A 2BXPA 3MHHB 4K2CA 4BY9C 1O9XA 2DBWA 2NNWA 4TQ1A 1LOTA 4ZC6A 4F5VA 4J2VA 1KXPD 4LUHA 1E7FA 4Z69A 2BXIA 3B9MA 5GIOA 4FIPB 3KIKA 3NVMA 4L8UA 3SIUB 1UORA 1MIYA 1TXUA 4TQ0A 4ZBQA 1NT2B 4ZBKA 2V36A 3KJLA 5FUOA 3WHSA 2I2ZA 2BX8A 3W1SA 2DBXA 5ID9A 4ZCGA 1H5WA 3VQIA 2XVUA 1KW2A 4GDKB 3PLAA 5IIXA 4C31B 5IIUA 2YDFA 5DQFA 2BXQA 2QHBA 4EMXA 2DYMA 4G04A 1E7CA 2AJEA 4G01A 1E7GA 4DHXB 4M70B 5IIHA 2BXKA 2BXOA 3JRYA 2BXLA 4NAWB 1E7HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DG5 A;  2DBW A;  2Z8I A;  4ZC6 A;  5B5T A;  2DBU A;  2E0X A;  3WHR A;  4GDX A;  4OTU A;  2Z8J A;  4ZBK A;  2V36 A;  3WHS A;  3A75 A;  2DBX A;  4ZCG A;  4OTT A;  5BPK A;  2NQO A;  4GG2 A;  4Z9O A;  2QMC A;  2QM6 A;  2Z8K A;  2E0Y A;  3WHQ A;  3FNM A; 
#chains in the Genus database with same CATH topology
 2XVV A;  4N0U D;  2DG5 A;  4WA6 B;  2LQI A;  4ZUX V;  3CX9 A;  3FWB C;  4OT2 A;  1JNB A;  2LOQ A;  4HGM B;  2LQH A;  4PO0 A;  1MUS A;  5B5T A;  1BM0 A;  1AO6 A;  1SB0 A;  1HK1 A;  3MHS B;  2E0X A;  5HOZ A;  4F5T A;  1HK3 A;  2JUH A;  2OT3 A;  3A73 A;  2EFD A;  4BKE A;  5GIP A;  2K0N A;  2CKX A;  1GNI A;  1HA2 A;  2BXC A;  2VDB A;  2BXM A;  1IJG A;  3A75 A;  4K71 A;  4LA0 A;  3LU6 A;  4N3Z A;  1E78 A;  4OTT A;  2BXG A;  4GDL B;  5IJ5 A;  5D7G A;  2XW0 A;  4HGK A;  2BXE A;  4DM0 A;  5IJE A;  5GIN A;  4LB9 A;  2EFH A;  2Z8K A;  5IFO A;  3WHQ A;  4OR0 A;  2ROH A;  3FWC C;  4I9O A;  3LU7 A;  1HK4 A;  1N5U A;  2XMO A;  3B9L A;  3NMU A;  1E7A A;  2Z8I A;  2KBZ A;  5IJF A;  2BXF A;  2KWF A;  3WHR A;  1E7E A;  1KDX A;  4OTU A;  3H3A A;  1MIW A;  2VUE A;  1BJ5 A;  3GQX A;  3FNM A;  3ICX A;  4MBE C;  1HK2 A;  4F5U A;  3NVK A;  2EFC A;  2I30 A;  4FK5 B;  5ID7 A;  2BXB A;  2LXS A;  2BXH A;  2NQO A;  2XVW A;  4GG2 A;  4LUF A;  1LNS A;  3LU8 A;  1VFI A;  4Z9O A;  3UIV A;  1VZS A;  4FJC B;  3V03 A;  3ECP A;  2QMC A;  2QM6 A;  4IW1 A;  1TF0 A;  1E7I A;  1E7B A;  2AGH B;  3H37 A;  1GNJ A;  2DYO A;  1HK5 A;  4N0F D;  2BXN A;  5GHK A;  2BXA A;  1H9Z A;  3V09 A;  3GA9 L;  2DBU A;  1J7E A;  4JK4 A;  1MA9 A;  4L9K A;  3TDL A;  1FOU A;  4ZBR A;  4GDX A;  2VUF A;  2GUT A;  2Z8J A;  4S1Y A;  2XW1 A;  3SIV B;  1BKE A;  1MIV A;  2EFE A;  4G03 A;  4F5S A;  3SQJ A;  4L9Q A;  2XVQ A;  4E99 A;  4IW2 A;  3BPJ A;  3JQZ A;  3M99 C;  5BPK A;  2BXD A;  3V08 A;  1MUH A;  4W4U B;  2XSI A;  3G9K D;  2OZB B;  4LB2 A;  3GQU A;  4D7X A;  3NVI A;  2E0Y A;  5DBY A;  1J78 A;  2BXP A;  3MHH B;  4K2C A;  4BY9 C;  1O9X A;  2DBW A;  2NNW A;  4TQ1 A;  1LOT A;  2LXT A;  4ZC6 A;  4F5V A;  4J2V A;  1KXP D;  4LUH A;  1E7F A;  4Z69 A;  2BXI A;  3B9M A;  5GIO A;  4FIP B;  3KIK A;  3NVM A;  4L8U A;  3SIU B;  1UOR A;  1MIY A;  1TXU A;  4TQ0 A;  4ZBQ A;  1NT2 B;  4ZBK A;  2V36 A;  3KJL A;  5FUO A;  3WHS A;  2I2Z A;  2BX8 A;  3W1S A;  2DBX A;  5ID9 A;  4ZCG A;  1H5W A;  3VQI A;  2XVU A;  1KW2 A;  4GDK B;  3PLA A;  5IIX A;  4C31 B;  5IIU A;  2YDF A;  5DQF A;  2BXQ A;  2QHB A;  4EMX A;  2DYM A;  1MM8 A;  4G04 A;  1E7C A;  2AJE A;  4G01 A;  1E7G A;  4DHX B;  4M70 B;  5IIH A;  2BXK A;  2BXO A;  3JRY A;  2BXL A;  4NAW B;  1E7H A; 
#chains in the Genus database with same CATH homology
 2XVV A;  4N0U D;  2DG5 A;  4WA6 B;  4ZUX V;  3CX9 A;  3FWB C;  4OT2 A;  1JNB A;  2LOQ A;  4HGM B;  4PO0 A;  5B5T A;  1BM0 A;  1AO6 A;  4F5T A;  1HK1 A;  3MHS B;  2E0X A;  5HOZ A;  1HK3 A;  2JUH A;  2OT3 A;  3A73 A;  2EFD A;  4BKE A;  5GIP A;  2CKX A;  1GNI A;  1HA2 A;  2BXC A;  2VDB A;  2BXM A;  1IJG A;  3A75 A;  4K71 A;  4LA0 A;  3LU6 A;  4N3Z A;  1E78 A;  4OTT A;  2BXG A;  4GDL B;  5IJ5 A;  5D7G A;  2XW0 A;  4HGK A;  2BXE A;  5IJE A;  5GIN A;  4LB9 A;  2EFH A;  2Z8K A;  5IFO A;  3WHQ A;  4OR0 A;  2ROH A;  3FWC C;  3LU7 A;  1HK4 A;  1N5U A;  2XMO A;  3B9L A;  3NMU A;  1E7A A;  2Z8I A;  2KBZ A;  5IJF A;  2BXF A;  3WHR A;  1E7E A;  4OTU A;  3H3A A;  1MIW A;  2VUE A;  1BJ5 A;  3GQX A;  3FNM A;  3ICX A;  4MBE C;  1HK2 A;  4F5U A;  3NVK A;  2EFC A;  2I30 A;  4FK5 B;  5ID7 A;  2BXB A;  2BXH A;  2NQO A;  2XVW A;  4GG2 A;  4LUF A;  1LNS A;  3LU8 A;  1VFI A;  4Z9O A;  3UIV A;  1VZS A;  4FJC B;  3V03 A;  2QMC A;  2QM6 A;  4IW1 A;  1TF0 A;  1E7I A;  1E7B A;  3H37 A;  1GNJ A;  2DYO A;  1HK5 A;  4N0F D;  2BXN A;  5GHK A;  2BXA A;  1H9Z A;  3V09 A;  3GA9 L;  2DBU A;  1J7E A;  4JK4 A;  1MA9 A;  4L9K A;  3TDL A;  1FOU A;  4ZBR A;  4GDX A;  2VUF A;  2Z8J A;  4S1Y A;  3SIV B;  2XW1 A;  1BKE A;  1MIV A;  2EFE A;  4G03 A;  4F5S A;  3SQJ A;  4L9Q A;  2XVQ A;  4E99 A;  4IW2 A;  3JQZ A;  3M99 C;  5BPK A;  2BXD A;  3V08 A;  4W4U B;  2XSI A;  3G9K D;  2OZB B;  4LB2 A;  3GQU A;  3NVI A;  2E0Y A;  5DBY A;  1J78 A;  2BXP A;  3MHH B;  4K2C A;  4BY9 C;  1O9X A;  2DBW A;  2NNW A;  4TQ1 A;  1LOT A;  4ZC6 A;  4F5V A;  4J2V A;  1KXP D;  4LUH A;  1E7F A;  4Z69 A;  2BXI A;  3B9M A;  5GIO A;  4FIP B;  3KIK A;  3NVM A;  4L8U A;  3SIU B;  1UOR A;  1MIY A;  1TXU A;  4TQ0 A;  4ZBQ A;  1NT2 B;  4ZBK A;  2V36 A;  3KJL A;  5FUO A;  3WHS A;  2I2Z A;  2BX8 A;  3W1S A;  2DBX A;  5ID9 A;  4ZCG A;  1H5W A;  3VQI A;  2XVU A;  1KW2 A;  4GDK B;  3PLA A;  5IIX A;  4C31 B;  5IIU A;  2YDF A;  5DQF A;  2BXQ A;  2QHB A;  4EMX A;  2DYM A;  4G04 A;  1E7C A;  2AJE A;  4G01 A;  1E7G A;  4DHX B;  4M70 B;  5IIH A;  2BXK A;  2BXO A;  3JRY A;  2BXL A;  4NAW B;  1E7H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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