5BPKA

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
348
structure length
348
Chain Sequence
ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
rcsb
molecule tags Hydrolase
source organism Helicobacter pylori 26695
molecule keywords Gamma-glutamyltranspeptidase (Ggt)
total genus 107
structure length 348
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.130 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5bpkA02
4OTTA 5BPKA 2Z8IA 2Z8KA 4Z9OA 3WHRA 2DG5A 2E0XA 2V36A 2E0YA 3WHSA 2NQOA 4ZCGA 4ZBKA 2QMCA 4ZC6A 2DBXA 5B5TA 3FNMA 2DBWA 2QM6A 3A75A 4OTUA 2DBUA 3WHQA 4GG2A 2Z8JA 4GDXA
chains in the Genus database with same CATH superfamily
4FK5B 4L9QA 4OTTA 4LA0A 2BXGA 3KIKA 1HK5A 3LU8A 1E7GA 2XW1A 2XSIA 4G04A 3H37A 4C31B 1IJGA 4W4UB 3WHRA 3V03A 2BXQA 2BXEA 3VQIA 4DM0A 2K0NA 2V36A 2DYOA 1H5WA 1N5UA 2LQIA 4NAWB 2BXNA 3ICXA 3V09A 2NQOA 2EFCA 3GQUA 3B9MA 4PO0A 2JUHA 2BXCA 4EMXA 1HK1A 2LOQA 2DBXA 2BXBA 4TQ0A 2I30A 2BXHA 2KBZA 3JRYA 4GDKB 1HA2A 2XVQA 2BXMA 2BXFA 2BXAA 2LXSA 4Z69A 3LU7A 1TF0A 4ZBRA 5ID7A 1BM0A 3CX9A 3GA9L 5GHKA 5IIHA 4MBEC 2LQHA 3NVKA 1GNIA 1MIYA 4G03A 2Z8KA 2OZBB 2XVUA 5GINA 2DG5A 3A73A 4K71A 5DQFA 1JNBA 3BPJA 3FWBC 3LU6A 4M70B 1MA9A 4N0FD 3NVIA 4FJCB 3WHSA 1E78A 3MHHB 1KXPD 2EFEA 1J78A 1H9ZA 3B9LA 1KDXA 4DHXB 2QMCA 3W1SA 1NT2B 4ZC6A 5HOZA 4BKEA 4F5VA 3FNMA 2XMOA 5GIPA 2DBWA 2KWFA 2LXTA 2QM6A 2NNWA 2XVWA 2VDBA 4OR0A 4WA6B 2DYMA 1E7FA 1UORA 3H3AA 4GDXA 1HK3A 2BX8A 2GUTA 3NVMA 3TDLA 2AGHB 1E7HA 4F5SA 5IJ5A 4FIPB 1GNJA 4ZUXV 1SB0A 3MHSB 4OT2A 4Z9OA 2ROHA 1BKEA 4JK4A 3PLAA 1O9XA 2E0YA 2BXLA 2EFDA 4IW1A 2CKXA 2OT3A 4F5UA 5FUOA 3NMUA 1E7EA 4D7XA 1KW2A 1MM8A 2QHBA 1FOUA 1LOTA 1AO6A 4ZBQA 1MIVA 2BXPA 3JQZA 4N3ZA 1MUSA 4K2CA 2BXIA 1BJ5A 2BXDA 4LB9A 5B5TA 1MUHA 4LUFA 3FWCC 3GQXA 3A75A 2VUFA 4L9KA 4OTUA 1E7IA 2XW0A 3WHQA 4E99A 5ID9A 1E7CA 2BXKA 1VZSA 4J2VA 5IJFA 5IIUA 4TQ1A 3UIVA 1VFIA 4L8UA 5BPKA 4HGKA 2AJEA 2Z8IA 4LB2A 4LUHA 3SIUB 3G9KD 1LNSA 5DBYA 4S1YA 1E7BA 2E0XA 2XVVA 1HK2A 3KJLA 4HGMB 4F5TA 1TXUA 5IJEA 5IFOA 3SIVB 4BY9C 2I2ZA 4ZCGA 4I9OA 2VUEA 5D7GA 4N0UD 2Z8JA 3M99C 2BXOA 1E7AA 4ZBKA 1MIWA 4G01A 3ECPA 1HK4A 5GIOA 2EFHA 5IIXA 3V08A 1J7EA 4GDLB 4IW2A 2DBUA 4GG2A 2YDFA 3SQJA
chains in the Genus database with same CATH topology
4FK5B 4L9QA 4OTTA 4LA0A 2BXGA 3KIKA 1HK5A 3LU8A 1E7GA 2XW1A 2XSIA 4G04A 3H37A 4C31B 1IJGA 4W4UB 3WHRA 3V03A 2BXQA 2BXEA 3VQIA 2V36A 2DYOA 1H5WA 1N5UA 4NAWB 2BXNA 3ICXA 3V09A 2NQOA 2EFCA 3GQUA 3B9MA 4PO0A 2JUHA 2BXCA 4EMXA 1HK1A 2LOQA 2DBXA 2BXBA 4TQ0A 2I30A 2BXHA 2KBZA 3JRYA 4GDKB 1HA2A 2XVQA 2BXMA 2BXFA 2BXAA 5ID7A 4Z69A 3LU7A 1TF0A 4ZBRA 1BM0A 3CX9A 3GA9L 5GHKA 5IIHA 4MBEC 3NVKA 1GNIA 1MIYA 4G03A 2Z8KA 2OZBB 2XVUA 5GINA 2DG5A 3A73A 4K71A 5DQFA 1JNBA 3FWBC 4M70B 3LU6A 1MA9A 4N0FD 3NVIA 4FJCB 3WHSA 1E78A 3MHHB 1KXPD 2EFEA 1J78A 1H9ZA 3B9LA 4DHXB 2QMCA 3W1SA 1NT2B 4ZC6A 5HOZA 4BKEA 4F5VA 3FNMA 2XMOA 5GIPA 2DBWA 2QM6A 2NNWA 2XVWA 2VDBA 4OR0A 4WA6B 2DYMA 1E7FA 1UORA 3H3AA 4GDXA 1HK3A 2BX8A 3NVMA 3TDLA 1E7HA 4F5SA 5IJ5A 4FIPB 1GNJA 4ZUXV 3MHSB 4OT2A 4Z9OA 2ROHA 1BKEA 4JK4A 3PLAA 1O9XA 2E0YA 2BXLA 2EFDA 4IW1A 2CKXA 2OT3A 4F5UA 5FUOA 3NMUA 1E7EA 1KW2A 2QHBA 1FOUA 1LOTA 1AO6A 4ZBQA 1MIVA 2BXPA 3JQZA 4N3ZA 4K2CA 2BXIA 1BJ5A 2BXDA 4LB9A 5B5TA 4LUFA 3FWCC 3GQXA 3A75A 2VUFA 4L9KA 4OTUA 1E7IA 2XW0A 3WHQA 4E99A 5ID9A 1E7CA 2BXKA 1VZSA 4J2VA 5IJFA 5IIUA 4TQ1A 3UIVA 1VFIA 4L8UA 5BPKA 4HGKA 2AJEA 2Z8IA 4LB2A 4LUHA 3SIUB 3G9KD 1LNSA 5DBYA 4S1YA 1E7BA 2E0XA 2XVVA 1HK2A 3KJLA 4HGMB 4F5TA 1TXUA 5IJEA 5IFOA 3SIVB 4BY9C 2I2ZA 4ZCGA 2VUEA 5D7GA 4N0UD 2Z8JA 3M99C 2BXOA 1E7AA 4ZBKA 1MIWA 4G01A 1HK4A 5GIOA 2EFHA 5IIXA 3V08A 1J7EA 4GDLB 4IW2A 2DBUA 4GG2A 2YDFA 3SQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OTT A;  5BPK A;  2Z8I A;  2Z8K A;  4Z9O A;  3WHR A;  2DG5 A;  2E0X A;  2V36 A;  2E0Y A;  3WHS A;  2NQO A;  4ZCG A;  4ZBK A;  2QMC A;  4ZC6 A;  2DBX A;  5B5T A;  3FNM A;  2DBW A;  2QM6 A;  3A75 A;  4OTU A;  2DBU A;  3WHQ A;  4GG2 A;  2Z8J A;  4GDX A; 
#chains in the Genus database with same CATH topology
 4FK5 B;  4L9Q A;  4OTT A;  4LA0 A;  2BXG A;  3KIK A;  1HK5 A;  3LU8 A;  1E7G A;  2XW1 A;  2XSI A;  4G04 A;  3H37 A;  4C31 B;  1IJG A;  4W4U B;  3WHR A;  3V03 A;  2BXQ A;  2BXE A;  3VQI A;  4DM0 A;  2K0N A;  2V36 A;  2DYO A;  1H5W A;  1N5U A;  2LQI A;  4NAW B;  2BXN A;  3ICX A;  3V09 A;  2NQO A;  2EFC A;  3GQU A;  3B9M A;  4PO0 A;  2JUH A;  2BXC A;  4EMX A;  1HK1 A;  2LOQ A;  2DBX A;  2BXB A;  4TQ0 A;  2I30 A;  2BXH A;  2KBZ A;  3JRY A;  4GDK B;  1HA2 A;  2XVQ A;  2BXM A;  2BXF A;  2BXA A;  2LXS A;  4Z69 A;  3LU7 A;  1TF0 A;  4ZBR A;  5ID7 A;  1BM0 A;  3CX9 A;  3GA9 L;  5GHK A;  5IIH A;  4MBE C;  2LQH A;  3NVK A;  1GNI A;  1MIY A;  4G03 A;  2Z8K A;  2OZB B;  2XVU A;  5GIN A;  2DG5 A;  3A73 A;  4K71 A;  5DQF A;  1JNB A;  3BPJ A;  3FWB C;  3LU6 A;  4M70 B;  1MA9 A;  4N0F D;  3NVI A;  4FJC B;  3WHS A;  1E78 A;  3MHH B;  1KXP D;  2EFE A;  1J78 A;  1H9Z A;  3B9L A;  1KDX A;  4DHX B;  2QMC A;  3W1S A;  1NT2 B;  4ZC6 A;  5HOZ A;  4BKE A;  4F5V A;  3FNM A;  2XMO A;  5GIP A;  2DBW A;  2KWF A;  2LXT A;  2QM6 A;  2NNW A;  2XVW A;  2VDB A;  4OR0 A;  4WA6 B;  2DYM A;  1E7F A;  1UOR A;  3H3A A;  4GDX A;  1HK3 A;  2BX8 A;  2GUT A;  3NVM A;  3TDL A;  2AGH B;  1E7H A;  4F5S A;  5IJ5 A;  4FIP B;  1GNJ A;  4ZUX V;  1SB0 A;  3MHS B;  4OT2 A;  4Z9O A;  2ROH A;  1BKE A;  4JK4 A;  3PLA A;  1O9X A;  2E0Y A;  2BXL A;  2EFD A;  4IW1 A;  2CKX A;  2OT3 A;  4F5U A;  5FUO A;  3NMU A;  1E7E A;  4D7X A;  1KW2 A;  1MM8 A;  2QHB A;  1FOU A;  1LOT A;  1AO6 A;  4ZBQ A;  1MIV A;  2BXP A;  3JQZ A;  4N3Z A;  1MUS A;  4K2C A;  2BXI A;  1BJ5 A;  2BXD A;  4LB9 A;  5B5T A;  1MUH A;  4LUF A;  3FWC C;  3GQX A;  3A75 A;  2VUF A;  4L9K A;  4OTU A;  1E7I A;  2XW0 A;  3WHQ A;  4E99 A;  5ID9 A;  1E7C A;  2BXK A;  1VZS A;  4J2V A;  5IJF A;  5IIU A;  4TQ1 A;  3UIV A;  1VFI A;  4L8U A;  5BPK A;  4HGK A;  2AJE A;  2Z8I A;  4LB2 A;  4LUH A;  3SIU B;  3G9K D;  1LNS A;  5DBY A;  4S1Y A;  1E7B A;  2E0X A;  2XVV A;  1HK2 A;  3KJL A;  4HGM B;  4F5T A;  1TXU A;  5IJE A;  5IFO A;  3SIV B;  4BY9 C;  2I2Z A;  4ZCG A;  4I9O A;  2VUE A;  5D7G A;  4N0U D;  2Z8J A;  3M99 C;  2BXO A;  1E7A A;  4ZBK A;  1MIW A;  4G01 A;  3ECP A;  1HK4 A;  5GIO A;  2EFH A;  5IIX A;  3V08 A;  1J7E A;  4GDL B;  4IW2 A;  2DBU A;  4GG2 A;  2YDF A;  3SQJ A; 
#chains in the Genus database with same CATH homology
 4FK5 B;  4L9Q A;  4OTT A;  4LA0 A;  2BXG A;  3KIK A;  1HK5 A;  3LU8 A;  1E7G A;  2XW1 A;  2XSI A;  4G04 A;  3H37 A;  4C31 B;  1IJG A;  4W4U B;  3WHR A;  3V03 A;  2BXQ A;  2BXE A;  3VQI A;  2V36 A;  2DYO A;  1H5W A;  1N5U A;  4NAW B;  2BXN A;  3ICX A;  3V09 A;  2NQO A;  2EFC A;  3GQU A;  3B9M A;  4PO0 A;  2JUH A;  2BXC A;  4EMX A;  1HK1 A;  2LOQ A;  2DBX A;  2BXB A;  4TQ0 A;  2I30 A;  2BXH A;  2KBZ A;  3JRY A;  4GDK B;  1HA2 A;  2XVQ A;  2BXM A;  2BXF A;  2BXA A;  5ID7 A;  4Z69 A;  3LU7 A;  1TF0 A;  4ZBR A;  1BM0 A;  3CX9 A;  3GA9 L;  5GHK A;  5IIH A;  4MBE C;  3NVK A;  1GNI A;  1MIY A;  4G03 A;  2Z8K A;  2OZB B;  2XVU A;  5GIN A;  2DG5 A;  3A73 A;  4K71 A;  5DQF A;  1JNB A;  3FWB C;  4M70 B;  3LU6 A;  1MA9 A;  4N0F D;  3NVI A;  4FJC B;  3WHS A;  1E78 A;  3MHH B;  1KXP D;  2EFE A;  1J78 A;  1H9Z A;  3B9L A;  4DHX B;  2QMC A;  3W1S A;  1NT2 B;  4ZC6 A;  5HOZ A;  4BKE A;  4F5V A;  3FNM A;  2XMO A;  5GIP A;  2DBW A;  2QM6 A;  2NNW A;  2XVW A;  2VDB A;  4OR0 A;  4WA6 B;  2DYM A;  1E7F A;  1UOR A;  3H3A A;  4GDX A;  1HK3 A;  2BX8 A;  3NVM A;  3TDL A;  1E7H A;  4F5S A;  5IJ5 A;  4FIP B;  1GNJ A;  4ZUX V;  3MHS B;  4OT2 A;  4Z9O A;  2ROH A;  1BKE A;  4JK4 A;  3PLA A;  1O9X A;  2E0Y A;  2BXL A;  2EFD A;  4IW1 A;  2CKX A;  2OT3 A;  4F5U A;  5FUO A;  3NMU A;  1E7E A;  1KW2 A;  2QHB A;  1FOU A;  1LOT A;  1AO6 A;  4ZBQ A;  1MIV A;  2BXP A;  3JQZ A;  4N3Z A;  4K2C A;  2BXI A;  1BJ5 A;  2BXD A;  4LB9 A;  5B5T A;  4LUF A;  3FWC C;  3GQX A;  3A75 A;  2VUF A;  4L9K A;  4OTU A;  1E7I A;  2XW0 A;  3WHQ A;  4E99 A;  5ID9 A;  1E7C A;  2BXK A;  1VZS A;  4J2V A;  5IJF A;  5IIU A;  4TQ1 A;  3UIV A;  1VFI A;  4L8U A;  5BPK A;  4HGK A;  2AJE A;  2Z8I A;  4LB2 A;  4LUH A;  3SIU B;  3G9K D;  1LNS A;  5DBY A;  4S1Y A;  1E7B A;  2E0X A;  2XVV A;  1HK2 A;  3KJL A;  4HGM B;  4F5T A;  1TXU A;  5IJE A;  5IFO A;  3SIV B;  4BY9 C;  2I2Z A;  4ZCG A;  2VUE A;  5D7G A;  4N0U D;  2Z8J A;  3M99 C;  2BXO A;  1E7A A;  4ZBK A;  1MIW A;  4G01 A;  1HK4 A;  5GIO A;  2EFH A;  5IIX A;  3V08 A;  1J7E A;  4GDL B;  4IW2 A;  2DBU A;  4GG2 A;  2YDF A;  3SQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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