5BPKA

Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
Total Genus 107
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
107
sequence length
348
structure length
348
Chain Sequence
ASYPPIKNTKVGLALSSHPLASEIGQKVLEEGGNAIDAAVAIGFALAVVHPAAGNIGGGGFAVIHLANGENVALDFREKAPLKATKNMFLDKQGNVVPKLSEDGYLAAGVPGTVAGMEAMLKKYGTKKLSQLIDPAIKLAENGYAISQRQAETLKEARERFLKYSSSKKYFFKKGHLDYQEGDLFVQKDLAKTLNQIKTLGAKGFYQGQVAELIEKDMKKNGGIITKEDLASYNVKWRKPVVGSYRGYKIISMSPPSSGGTHLIQILNVMENADLSALGYGASKNIHIAAEAMRQAYADRSVYMGDADFVSVPVDKLINKAYAKKIFDTIQPDTVTPSSQIKPGMGQL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Gamma-glutamyltranspeptidase (Ggt)
publication title Varying binding modes of inhibitors and structural differences in the binding pockets of different gamma-glutamyltranspeptidases
rcsb
source organism Helicobacter pylori 26695
total genus 107
structure length 348
sequence length 348
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-05-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.130 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5bpkA02
2DBUA 2Z8IA 3WHSA 4OTTA 2Z8KA 2V36A 2DBXA 4GG2A 3A75A 4ZC6A 4ZBKA 2E0XA 2QM6A 4GDXA 2E0YA 2QMCA 3WHQA 2DG5A 5B5TA 4OTUA 2NQOA 3FNMA 4ZCGA 4Z9OA 2Z8JA 5BPKA 3WHRA 2DBWA
chains in the Genus database with same CATH superfamily
2DBUA 5IJ5A 4Z69A 4LB2A 4EMXA 4BY9C 2XW1A 3LU6A 1E7IA 4F5TA 5GIPA 2BXLA 4OT2A 4OTTA 1KDXA 2BXQA 2LQHA 4K2CA 5HOZA 3NMUA 3ECPA 2EFHA 2DBXA 1O9XA 2LOQA 4HGMB 1MUHA 3GA9L 2K0NA 4GG2A 5DBYA 2XVQA 1VFIA 3H3AA 4TQ0A 1GNIA 2BXOA 4ZBKA 1AO6A 4F5SA 3SIUB 3A73A 1E7CA 2KBZA 5IJEA 4GDXA 2VDBA 3FWBC 3V08A 5IIUA 2OT3A 2BXMA 1MM8A 1J78A 1SB0A 4GDKB 1HK5A 2AGHB 2YDFA 3G9KD 2BXEA 5D7GA 2Z8JA 5ID9A 2XSIA 3W1SA 4WA6B 3WHRA 4F5UA 3B9LA 4L9QA 4G04A 3JQZA 4ZBQA 3MHSB 3UIVA 3M99C 4OR0A 3KJLA 3WHSA 4BKEA 1MIVA 4MBEC 2XVUA 1BM0A 2ROHA 2Z8KA 2V36A 4TQ1A 4ZUXV 4LB9A 2LQIA 2BXAA 1E7GA 2DYOA 2DYMA 4I9OA 1KXPD 3TDLA 5FUOA 2E0XA 3NVKA 2BXFA 2BXIA 1HK2A 4J2VA 2EFCA 2BXBA 5GINA 4L9KA 2XVVA 1LOTA 2NQOA 3PLAA 4L8UA 2NNWA 3FNMA 4D7XA 5ID7A 4ZCGA 1TF0A 3BPJA 2BX8A 3CX9A 1NT2B 1H9ZA 4N3ZA 4ZBRA 5BPKA 3GQXA 1H5WA 1J7EA 4M70B 1GNJA 4LUFA 1IJGA 1LNSA 1UORA 4IW2A 2Z8IA 4DM0A 4S1YA 2EFEA 3V09A 2QHBA 3MHHB 3SQJA 2VUEA 4K71A 5GIOA 5IIHA 1MUSA 4HGKA 1VZSA 1MA9A 4E99A 3LU8A 3VQIA 4ZC6A 5IFOA 4G01A 2LXSA 2LXTA 3NVIA 1HK3A 3ICXA 4PO0A 2GUTA 2AJEA 1N5UA 3FWCC 2BXCA 5IIXA 1TXUA 1E7FA 2E0YA 1MIWA 2QMCA 2BXPA 4FJCB 3NVMA 5B5TA 1E7BA 4OTUA 4N0UD 4G03A 3V03A 4LUHA 3SIVB 2BXGA 2DBWA 2KWFA 2EFDA 4DHXB 2JUHA 1E78A 1KW2A 3KIKA 1MIYA 3GQUA 2CKXA 4JK4A 4IW1A 2OZBB 4FK5B 4C31B 5IJFA 1HA2A 5GHKA 5DQFA 1JNBA 3A75A 3LU7A 2BXNA 2I2ZA 1BKEA 1E7AA 2BXHA 1HK4A 4N0FD 4W4UB 3B9MA 3H37A 4GDLB 2I30A 2QM6A 2XW0A 1E7EA 1FOUA 2BXKA 2VUFA 1HK1A 3WHQA 2DG5A 2XVWA 2BXDA 2XMOA 3JRYA 4FIPB 4F5VA 4NAWB 4Z9OA 1E7HA 1BJ5A 4LA0A
chains in the Genus database with same CATH topology
2DBUA 5IJ5A 4Z69A 4LB2A 4EMXA 4BY9C 2XW1A 3LU6A 1E7IA 4F5TA 5GIPA 2BXLA 4OT2A 4OTTA 2BXQA 4K2CA 5HOZA 3NMUA 2EFHA 2DBXA 1O9XA 2LOQA 4HGMB 3GA9L 4GG2A 5DBYA 2XVQA 1VFIA 3H3AA 4TQ0A 1GNIA 2BXOA 4ZBKA 1AO6A 4F5SA 3SIUB 3A73A 1E7CA 2KBZA 5IJEA 4GDXA 2VDBA 3FWBC 3V08A 5IIUA 2OT3A 2BXMA 1J78A 4GDKB 1HK5A 2YDFA 3G9KD 2BXEA 5D7GA 2Z8JA 5ID9A 2XSIA 3W1SA 4WA6B 3WHRA 4F5UA 3B9LA 4L9QA 4G04A 3JQZA 4ZBQA 3MHSB 3UIVA 3M99C 4OR0A 3KJLA 3WHSA 4BKEA 1MIVA 4MBEC 2XVUA 1BM0A 2ROHA 2Z8KA 2V36A 4TQ1A 4ZUXV 4LB9A 2BXAA 1E7GA 2DYOA 2DYMA 3TDLA 1KXPD 5FUOA 2E0XA 3NVKA 2BXFA 2BXIA 1HK2A 4J2VA 2EFCA 2BXBA 5GINA 4L9KA 2XVVA 1LOTA 2NQOA 3PLAA 4L8UA 2NNWA 3FNMA 5ID7A 4ZCGA 1TF0A 2BX8A 3CX9A 1NT2B 1H9ZA 4N3ZA 4ZBRA 5BPKA 3GQXA 1H5WA 1J7EA 4M70B 1GNJA 4LUFA 1IJGA 1LNSA 1UORA 4IW2A 2Z8IA 4S1YA 2EFEA 3V09A 2QHBA 3MHHB 3SQJA 2VUEA 4K71A 5GIOA 5IIHA 4HGKA 1VZSA 1MA9A 4E99A 3LU8A 3VQIA 4ZC6A 5IFOA 4G01A 3NVIA 1HK3A 3ICXA 4PO0A 2AJEA 1N5UA 3FWCC 2BXCA 5IIXA 1TXUA 1E7FA 2E0YA 1MIWA 2QMCA 2BXPA 4FJCB 3NVMA 5B5TA 1E7BA 4OTUA 4N0UD 4G03A 3V03A 4LUHA 3SIVB 2BXGA 2DBWA 2EFDA 4DHXB 2JUHA 1E78A 1KW2A 3KIKA 1MIYA 3GQUA 2CKXA 4JK4A 4IW1A 2OZBB 4FK5B 4C31B 5IJFA 1HA2A 5GHKA 5DQFA 1JNBA 3A75A 3LU7A 2BXNA 2I2ZA 1BKEA 1E7AA 2BXHA 1HK4A 4N0FD 4W4UB 3B9MA 3H37A 4GDLB 2I30A 2QM6A 2XW0A 1E7EA 1FOUA 2BXKA 2VUFA 1HK1A 3WHQA 2DG5A 2XVWA 2BXDA 2XMOA 3JRYA 4FIPB 4F5VA 4NAWB 4Z9OA 1E7HA 1BJ5A 4LA0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DBU A;  2Z8I A;  3WHS A;  4OTT A;  2Z8K A;  2V36 A;  2DBX A;  4GG2 A;  3A75 A;  4ZC6 A;  4ZBK A;  2E0X A;  2QM6 A;  4GDX A;  2E0Y A;  2QMC A;  3WHQ A;  2DG5 A;  5B5T A;  4OTU A;  2NQO A;  3FNM A;  4ZCG A;  4Z9O A;  2Z8J A;  5BPK A;  3WHR A;  2DBW A; 
#chains in the Genus database with same CATH topology
 2DBU A;  5IJ5 A;  4Z69 A;  4LB2 A;  4EMX A;  4BY9 C;  2XW1 A;  3LU6 A;  1E7I A;  4F5T A;  5GIP A;  2BXL A;  4OT2 A;  4OTT A;  1KDX A;  2BXQ A;  2LQH A;  4K2C A;  5HOZ A;  3NMU A;  3ECP A;  2EFH A;  2DBX A;  1O9X A;  2LOQ A;  4HGM B;  1MUH A;  3GA9 L;  2K0N A;  4GG2 A;  5DBY A;  2XVQ A;  1VFI A;  3H3A A;  4TQ0 A;  1GNI A;  2BXO A;  4ZBK A;  1AO6 A;  4F5S A;  3SIU B;  3A73 A;  1E7C A;  2KBZ A;  5IJE A;  4GDX A;  2VDB A;  3FWB C;  3V08 A;  5IIU A;  2OT3 A;  2BXM A;  1MM8 A;  1J78 A;  1SB0 A;  4GDK B;  1HK5 A;  2AGH B;  2YDF A;  3G9K D;  2BXE A;  5D7G A;  2Z8J A;  5ID9 A;  2XSI A;  3W1S A;  4WA6 B;  3WHR A;  4F5U A;  3B9L A;  4L9Q A;  4G04 A;  3JQZ A;  4ZBQ A;  3MHS B;  3UIV A;  3M99 C;  4OR0 A;  3KJL A;  3WHS A;  4BKE A;  1MIV A;  4MBE C;  2XVU A;  1BM0 A;  2ROH A;  2Z8K A;  2V36 A;  4TQ1 A;  4ZUX V;  4LB9 A;  2LQI A;  2BXA A;  1E7G A;  2DYO A;  2DYM A;  4I9O A;  1KXP D;  3TDL A;  5FUO A;  2E0X A;  3NVK A;  2BXF A;  2BXI A;  1HK2 A;  4J2V A;  2EFC A;  2BXB A;  5GIN A;  4L9K A;  2XVV A;  1LOT A;  2NQO A;  3PLA A;  4L8U A;  2NNW A;  3FNM A;  4D7X A;  5ID7 A;  4ZCG A;  1TF0 A;  3BPJ A;  2BX8 A;  3CX9 A;  1NT2 B;  1H9Z A;  4N3Z A;  4ZBR A;  5BPK A;  3GQX A;  1H5W A;  1J7E A;  4M70 B;  1GNJ A;  4LUF A;  1IJG A;  1LNS A;  1UOR A;  4IW2 A;  2Z8I A;  4DM0 A;  4S1Y A;  2EFE A;  3V09 A;  2QHB A;  3MHH B;  3SQJ A;  2VUE A;  4K71 A;  5GIO A;  5IIH A;  1MUS A;  4HGK A;  1VZS A;  1MA9 A;  4E99 A;  3LU8 A;  3VQI A;  4ZC6 A;  5IFO A;  4G01 A;  2LXS A;  2LXT A;  3NVI A;  1HK3 A;  3ICX A;  4PO0 A;  2GUT A;  2AJE A;  1N5U A;  3FWC C;  2BXC A;  5IIX A;  1TXU A;  1E7F A;  2E0Y A;  1MIW A;  2QMC A;  2BXP A;  4FJC B;  3NVM A;  5B5T A;  1E7B A;  4OTU A;  4N0U D;  4G03 A;  3V03 A;  4LUH A;  3SIV B;  2BXG A;  2DBW A;  2KWF A;  2EFD A;  4DHX B;  2JUH A;  1E78 A;  1KW2 A;  3KIK A;  1MIY A;  3GQU A;  2CKX A;  4JK4 A;  4IW1 A;  2OZB B;  4FK5 B;  4C31 B;  5IJF A;  1HA2 A;  5GHK A;  5DQF A;  1JNB A;  3A75 A;  3LU7 A;  2BXN A;  2I2Z A;  1BKE A;  1E7A A;  2BXH A;  1HK4 A;  4N0F D;  4W4U B;  3B9M A;  3H37 A;  4GDL B;  2I30 A;  2QM6 A;  2XW0 A;  1E7E A;  1FOU A;  2BXK A;  2VUF A;  1HK1 A;  3WHQ A;  2DG5 A;  2XVW A;  2BXD A;  2XMO A;  3JRY A;  4FIP B;  4F5V A;  4NAW B;  4Z9O A;  1E7H A;  1BJ5 A;  4LA0 A; 
#chains in the Genus database with same CATH homology
 2DBU A;  5IJ5 A;  4Z69 A;  4LB2 A;  4EMX A;  4BY9 C;  2XW1 A;  3LU6 A;  1E7I A;  4F5T A;  5GIP A;  2BXL A;  4OT2 A;  4OTT A;  2BXQ A;  4K2C A;  5HOZ A;  3NMU A;  2EFH A;  2DBX A;  1O9X A;  2LOQ A;  4HGM B;  3GA9 L;  4GG2 A;  5DBY A;  2XVQ A;  1VFI A;  3H3A A;  4TQ0 A;  1GNI A;  2BXO A;  4ZBK A;  1AO6 A;  4F5S A;  3SIU B;  3A73 A;  1E7C A;  2KBZ A;  5IJE A;  4GDX A;  2VDB A;  3FWB C;  3V08 A;  5IIU A;  2OT3 A;  2BXM A;  1J78 A;  4GDK B;  1HK5 A;  2YDF A;  3G9K D;  2BXE A;  5D7G A;  2Z8J A;  5ID9 A;  2XSI A;  3W1S A;  4WA6 B;  3WHR A;  4F5U A;  3B9L A;  4L9Q A;  4G04 A;  3JQZ A;  4ZBQ A;  3MHS B;  3UIV A;  3M99 C;  4OR0 A;  3KJL A;  3WHS A;  4BKE A;  1MIV A;  4MBE C;  2XVU A;  1BM0 A;  2ROH A;  2Z8K A;  2V36 A;  4TQ1 A;  4ZUX V;  4LB9 A;  2BXA A;  1E7G A;  2DYO A;  2DYM A;  3TDL A;  1KXP D;  5FUO A;  2E0X A;  3NVK A;  2BXF A;  2BXI A;  1HK2 A;  4J2V A;  2EFC A;  2BXB A;  5GIN A;  4L9K A;  2XVV A;  1LOT A;  2NQO A;  3PLA A;  4L8U A;  2NNW A;  3FNM A;  5ID7 A;  4ZCG A;  1TF0 A;  2BX8 A;  3CX9 A;  1NT2 B;  1H9Z A;  4N3Z A;  4ZBR A;  5BPK A;  3GQX A;  1H5W A;  1J7E A;  4M70 B;  1GNJ A;  4LUF A;  1IJG A;  1LNS A;  1UOR A;  4IW2 A;  2Z8I A;  4S1Y A;  2EFE A;  3V09 A;  2QHB A;  3MHH B;  3SQJ A;  2VUE A;  4K71 A;  5GIO A;  5IIH A;  4HGK A;  1VZS A;  1MA9 A;  4E99 A;  3LU8 A;  3VQI A;  4ZC6 A;  5IFO A;  4G01 A;  3NVI A;  1HK3 A;  3ICX A;  4PO0 A;  2AJE A;  1N5U A;  3FWC C;  2BXC A;  5IIX A;  1TXU A;  1E7F A;  2E0Y A;  1MIW A;  2QMC A;  2BXP A;  4FJC B;  3NVM A;  5B5T A;  1E7B A;  4OTU A;  4N0U D;  4G03 A;  3V03 A;  4LUH A;  3SIV B;  2BXG A;  2DBW A;  2EFD A;  4DHX B;  2JUH A;  1E78 A;  1KW2 A;  3KIK A;  1MIY A;  3GQU A;  2CKX A;  4JK4 A;  4IW1 A;  2OZB B;  4FK5 B;  4C31 B;  5IJF A;  1HA2 A;  5GHK A;  5DQF A;  1JNB A;  3A75 A;  3LU7 A;  2BXN A;  2I2Z A;  1BKE A;  1E7A A;  2BXH A;  1HK4 A;  4N0F D;  4W4U B;  3B9M A;  3H37 A;  4GDL B;  2I30 A;  2QM6 A;  2XW0 A;  1E7E A;  1FOU A;  2BXK A;  2VUF A;  1HK1 A;  3WHQ A;  2DG5 A;  2XVW A;  2BXD A;  2XMO A;  3JRY A;  4FIP B;  4F5V A;  4NAW B;  4Z9O A;  1E7H A;  1BJ5 A;  4LA0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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