5FUOA

Extending the half-life of a fab fragment through generation of a humanised anti-human serum albumin (hsa) fv domain: an investigation into the correlation between affinity and serum half-life
Total Genus 217
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
217
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords SERUM ALBUMIN
publication title Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
pubmed doi rcsb
source organism Homo sapiens
total genus 217
structure length 578
sequence length 578
ec nomenclature
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA05
3SQJA 2BXPA 5ID9A 3CX9A 5HOZA 1N5UA 1E7HA 4F5TA 1E7EA 4OR0A 1TF0A 1BKEA 1HK5A 4G04A 4IW1A 5GHKA 2VUEA 4E99A 4LUHA 5DQFA 2XVWA 4Z69A 4LUFA 1AO6A 1UORA 4IW2A 5IIXA 4LA0A 4HGMB 4N0FD 2BXDA 5IJFA 1BJ5A 1GNJA 2BXEA 1E7BA 4LB9A 3JQZA 4S1YA 1HA2A 2BXHA 1E7GA 1O9XA 1HK3A 2XSIA 1J7EA 1E7FA 2BXLA 4BKEA 4N0UD 4OT2A 1BM0A 2BXQA 5DBYA 2YDFA 4ZBQA 3LU7A 2BXOA 2BXAA 4L8UA 2XVQA 3V03A 3B9LA 5IJEA 3LU6A 2BXGA 1E7CA 4PO0A 2VUFA 4F5VA 4L9QA 2VDBA 1HK1A 4F5UA 3LU8A 3B9MA 4HGKA 1HK2A 1GNIA 1H9ZA 2XVVA 5FUOA 4G03A 4J2VA 1J78A 4LB2A 4JK4A 5IJ5A 1LOTA 2BXNA 2XW0A 1E7AA 1MA9A 3UIVA 1KW2A 2XVUA 4ZBRA 2BX8A 1HK4A 3A73A 5ID7A 5IIHA 2BXIA 2BXCA 3TDLA 2BXMA 4L9KA 4F5SA 5IFOA 1E78A 3V09A 1KXPD 1E7IA 4K71A 4K2CA 3JRYA 2I2ZA 2XW1A 4EMXA 2BXBA 3V08A 2BXKA 2BXFA 2I30A 5IIUA
chains in the Genus database with same CATH superfamily
3SQJA 2BXPA 3FWCC 5ID9A 3CX9A 2K0NA 5HOZA 1MUHA 1N5UA 3GQXA 3NMUA 3NVKA 1E7HA 4GDXA 2NNWA 4F5TA 1E7EA 3WHSA 4W4UB 4OR0A 2E0XA 1TF0A 1KDXA 1BKEA 1HK5A 2KBZA 1TXUA 4G04A 4IW1A 4WA6B 4ZCGA 1LNSA 2LQHA 3NVMA 4G01A 4MBEC 5GHKA 1VFIA 2VUEA 4E99A 3PLAA 4LUHA 2Z8IA 5DQFA 2XVWA 4Z69A 4LUFA 1AO6A 1UORA 2DYMA 4C31B 4FK5B 4IW2A 5IIXA 4LA0A 3FWBC 4HGMB 4N0FD 2QM6A 2BXDA 5IJFA 5GINA 4BY9C 4D7XA 1BJ5A 1GNJA 3WHQA 2BXEA 2XMOA 4FIPB 1IJGA 1E7BA 4LB9A 2CKXA 3JQZA 4N3ZA 1HA2A 2BXHA 2V36A 1E7GA 2GUTA 1O9XA 1HK3A 4OTTA 2XSIA 1J7EA 1E7FA 2BXLA 4BKEA 4N0UD 4ZUXV 1MUSA 1H5WA 4OT2A 3WHRA 1MM8A 3VQIA 1BM0A 4S1YA 2BXQA 5DBYA 2LOQA 3SIUB 1MIWA 2DBWA 2EFDA 2YDFA 2KWFA 3LU7A 4ZBQA 3H3AA 2BXOA 2BXAA 4L8UA 3W1SA 2XVQA 4TQ0A 3V03A 3MHSB 3B9LA 3M99C 5IJEA 2QHBA 1E7CA 2BXGA 1FOUA 3LU6A 4PO0A 2VUFA 4F5VA 4L9QA 2VDBA 2EFCA 4M70B 3ECPA 4FJCB 1HK1A 2LXTA 4F5UA 3GQUA 3LU8A 4DM0A 3B9MA 4HGKA 2JUHA 1HK2A 1GNIA 1H9ZA 2XVVA 3NVIA 2DYOA 1JNBA 1MIVA 5FUOA 1SB0A 4G03A 4J2VA 1J78A 4LB2A 4JK4A 5IJ5A 1LOTA 2BXNA 5GIOA 3G9KD 2XW0A 4DHXB 1E7AA 1MA9A 3UIVA 1KW2A 2XVUA 4I9OA 3KJLA 4OTUA 5D7GA 1MIYA 4ZBRA 5B5TA 2BX8A 4Z9OA 2NQOA 1HK4A 3ICXA 2DBUA 4ZC6A 3A73A 5ID7A 5IIHA 1VZSA 2BXIA 2Z8JA 2BXCA 2OT3A 2LQIA 4NAWB 4GDKB 4TQ1A 4ZBKA 2BXMA 3TDLA 2EFHA 4L9KA 2AJEA 2DBXA 3A75A 4F5SA 5IFOA 5GIPA 2LXSA 1E78A 3V09A 2QMCA 3BPJA 3FNMA 2AGHB 2EFEA 2OZBB 5BPKA 2Z8KA 1KXPD 1E7IA 4K71A 4GDLB 4K2CA 3JRYA 2I2ZA 3H37A 2DG5A 2XW1A 4GG2A 2BXBA 3V08A 2BXKA 4EMXA 2BXFA 3SIVB 2ROHA 3MHHB 2I30A 2E0YA 5IIUA 3GA9L 1NT2B 3KIKA
chains in the Genus database with same CATH topology
3SQJA 2BXPA 3FWCC 5ID9A 3CX9A 5HOZA 1N5UA 3GQXA 3NMUA 3NVKA 1E7HA 4GDXA 2NNWA 4F5TA 1E7EA 3WHSA 4W4UB 4OR0A 2E0XA 1TF0A 1BKEA 1HK5A 2KBZA 1TXUA 4G04A 4IW1A 4WA6B 4ZCGA 1LNSA 3NVMA 4G01A 4MBEC 5GHKA 1VFIA 2VUEA 4E99A 3PLAA 4LUHA 2Z8IA 5DQFA 2XVWA 4Z69A 4LUFA 1AO6A 1UORA 2DYMA 4C31B 4FK5B 4IW2A 5IIXA 4LA0A 3FWBC 4HGMB 4N0FD 2QM6A 2BXDA 5IJFA 5GINA 4BY9C 1BJ5A 1GNJA 3WHQA 2BXEA 2XMOA 4FIPB 1IJGA 1E7BA 4LB9A 2CKXA 3JQZA 4N3ZA 1HA2A 2BXHA 2V36A 1E7GA 4OTTA 1O9XA 1HK3A 4S1YA 2XSIA 1J7EA 1E7FA 2BXLA 4BKEA 4N0UD 4ZUXV 1H5WA 4OT2A 3WHRA 3VQIA 1BM0A 2BXQA 5DBYA 2LOQA 3SIUB 1MIWA 2DBWA 2EFDA 2YDFA 4ZBQA 3LU7A 3H3AA 2BXOA 2BXAA 4L8UA 3W1SA 2XVQA 4TQ0A 3V03A 3MHSB 3B9LA 3M99C 5IJEA 2QHBA 1E7CA 2BXGA 1FOUA 3LU6A 4PO0A 2VUFA 4F5VA 4L9QA 2VDBA 2EFCA 4M70B 4FJCB 1HK1A 4F5UA 3GQUA 3LU8A 3B9MA 4HGKA 2JUHA 1HK2A 1GNIA 1H9ZA 2XVVA 3NVIA 2DYOA 1JNBA 1MIVA 5FUOA 4G03A 4J2VA 1J78A 4LB2A 4JK4A 5IJ5A 1LOTA 2BXNA 5GIOA 3G9KD 2XW0A 4DHXB 1E7AA 1MA9A 3UIVA 1KW2A 2XVUA 4OTUA 3KJLA 5D7GA 1MIYA 4ZBRA 5B5TA 2BX8A 4Z9OA 2NQOA 1HK4A 3ICXA 2DBUA 4ZC6A 3A73A 5ID7A 5IIHA 1VZSA 2BXIA 2Z8JA 2BXCA 2OT3A 4NAWB 4TQ1A 4GDKB 4ZBKA 2BXMA 3TDLA 2EFHA 4L9KA 2AJEA 2DBXA 3A75A 4F5SA 5IFOA 5GIPA 1E78A 3V09A 2QMCA 2OZBB 3FNMA 2EFEA 5BPKA 2Z8KA 1KXPD 1E7IA 4K71A 4GDLB 4K2CA 3JRYA 2I2ZA 3H37A 2DG5A 2XW1A 4GG2A 2BXBA 3V08A 2BXKA 4EMXA 2BXFA 3SIVB 2ROHA 3MHHB 2I30A 2E0YA 5IIUA 3GA9L 1NT2B 3KIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3SQJ A;  2BXP A;  5ID9 A;  3CX9 A;  5HOZ A;  1N5U A;  1E7H A;  4F5T A;  1E7E A;  4OR0 A;  1TF0 A;  1BKE A;  1HK5 A;  4G04 A;  4IW1 A;  5GHK A;  2VUE A;  4E99 A;  4LUH A;  5DQF A;  2XVW A;  4Z69 A;  4LUF A;  1AO6 A;  1UOR A;  4IW2 A;  5IIX A;  4LA0 A;  4HGM B;  4N0F D;  2BXD A;  5IJF A;  1BJ5 A;  1GNJ A;  2BXE A;  1E7B A;  4LB9 A;  3JQZ A;  4S1Y A;  1HA2 A;  2BXH A;  1E7G A;  1O9X A;  1HK3 A;  2XSI A;  1J7E A;  1E7F A;  2BXL A;  4BKE A;  4N0U D;  4OT2 A;  1BM0 A;  2BXQ A;  5DBY A;  2YDF A;  4ZBQ A;  3LU7 A;  2BXO A;  2BXA A;  4L8U A;  2XVQ A;  3V03 A;  3B9L A;  5IJE A;  3LU6 A;  2BXG A;  1E7C A;  4PO0 A;  2VUF A;  4F5V A;  4L9Q A;  2VDB A;  1HK1 A;  4F5U A;  3LU8 A;  3B9M A;  4HGK A;  1HK2 A;  1GNI A;  1H9Z A;  2XVV A;  5FUO A;  4G03 A;  4J2V A;  1J78 A;  4LB2 A;  4JK4 A;  5IJ5 A;  1LOT A;  2BXN A;  2XW0 A;  1E7A A;  1MA9 A;  3UIV A;  1KW2 A;  2XVU A;  4ZBR A;  2BX8 A;  1HK4 A;  3A73 A;  5ID7 A;  5IIH A;  2BXI A;  2BXC A;  3TDL A;  2BXM A;  4L9K A;  4F5S A;  5IFO A;  1E78 A;  3V09 A;  1KXP D;  1E7I A;  4K71 A;  4K2C A;  3JRY A;  2I2Z A;  2XW1 A;  4EMX A;  2BXB A;  3V08 A;  2BXK A;  2BXF A;  2I30 A;  5IIU A; 
#chains in the Genus database with same CATH topology
 3SQJ A;  2BXP A;  3FWC C;  5ID9 A;  3CX9 A;  2K0N A;  5HOZ A;  1MUH A;  1N5U A;  3GQX A;  3NMU A;  3NVK A;  1E7H A;  4GDX A;  2NNW A;  4F5T A;  1E7E A;  3WHS A;  4W4U B;  4OR0 A;  2E0X A;  1TF0 A;  1KDX A;  1BKE A;  1HK5 A;  2KBZ A;  1TXU A;  4G04 A;  4IW1 A;  4WA6 B;  4ZCG A;  1LNS A;  2LQH A;  3NVM A;  4G01 A;  4MBE C;  5GHK A;  1VFI A;  2VUE A;  4E99 A;  3PLA A;  4LUH A;  2Z8I A;  5DQF A;  2XVW A;  4Z69 A;  4LUF A;  1AO6 A;  1UOR A;  2DYM A;  4C31 B;  4FK5 B;  4IW2 A;  5IIX A;  4LA0 A;  3FWB C;  4HGM B;  4N0F D;  2QM6 A;  2BXD A;  5IJF A;  5GIN A;  4BY9 C;  4D7X A;  1BJ5 A;  1GNJ A;  3WHQ A;  2BXE A;  2XMO A;  4FIP B;  1IJG A;  1E7B A;  4LB9 A;  2CKX A;  3JQZ A;  4N3Z A;  1HA2 A;  2BXH A;  2V36 A;  1E7G A;  2GUT A;  1O9X A;  1HK3 A;  4OTT A;  2XSI A;  1J7E A;  1E7F A;  2BXL A;  4BKE A;  4N0U D;  4ZUX V;  1MUS A;  1H5W A;  4OT2 A;  3WHR A;  1MM8 A;  3VQI A;  1BM0 A;  4S1Y A;  2BXQ A;  5DBY A;  2LOQ A;  3SIU B;  1MIW A;  2DBW A;  2EFD A;  2YDF A;  2KWF A;  3LU7 A;  4ZBQ A;  3H3A A;  2BXO A;  2BXA A;  4L8U A;  3W1S A;  2XVQ A;  4TQ0 A;  3V03 A;  3MHS B;  3B9L A;  3M99 C;  5IJE A;  2QHB A;  1E7C A;  2BXG A;  1FOU A;  3LU6 A;  4PO0 A;  2VUF A;  4F5V A;  4L9Q A;  2VDB A;  2EFC A;  4M70 B;  3ECP A;  4FJC B;  1HK1 A;  2LXT A;  4F5U A;  3GQU A;  3LU8 A;  4DM0 A;  3B9M A;  4HGK A;  2JUH A;  1HK2 A;  1GNI A;  1H9Z A;  2XVV A;  3NVI A;  2DYO A;  1JNB A;  1MIV A;  5FUO A;  1SB0 A;  4G03 A;  4J2V A;  1J78 A;  4LB2 A;  4JK4 A;  5IJ5 A;  1LOT A;  2BXN A;  5GIO A;  3G9K D;  2XW0 A;  4DHX B;  1E7A A;  1MA9 A;  3UIV A;  1KW2 A;  2XVU A;  4I9O A;  3KJL A;  4OTU A;  5D7G A;  1MIY A;  4ZBR A;  5B5T A;  2BX8 A;  4Z9O A;  2NQO A;  1HK4 A;  3ICX A;  2DBU A;  4ZC6 A;  3A73 A;  5ID7 A;  5IIH A;  1VZS A;  2BXI A;  2Z8J A;  2BXC A;  2OT3 A;  2LQI A;  4NAW B;  4GDK B;  4TQ1 A;  4ZBK A;  2BXM A;  3TDL A;  2EFH A;  4L9K A;  2AJE A;  2DBX A;  3A75 A;  4F5S A;  5IFO A;  5GIP A;  2LXS A;  1E78 A;  3V09 A;  2QMC A;  3BPJ A;  3FNM A;  2AGH B;  2EFE A;  2OZB B;  5BPK A;  2Z8K A;  1KXP D;  1E7I A;  4K71 A;  4GDL B;  4K2C A;  3JRY A;  2I2Z A;  3H37 A;  2DG5 A;  2XW1 A;  4GG2 A;  2BXB A;  3V08 A;  2BXK A;  4EMX A;  2BXF A;  3SIV B;  2ROH A;  3MHH B;  2I30 A;  2E0Y A;  5IIU A;  3GA9 L;  1NT2 B;  3KIK A; 
#chains in the Genus database with same CATH homology
 3SQJ A;  2BXP A;  3FWC C;  5ID9 A;  3CX9 A;  5HOZ A;  1N5U A;  3GQX A;  3NMU A;  3NVK A;  1E7H A;  4GDX A;  2NNW A;  4F5T A;  1E7E A;  3WHS A;  4W4U B;  4OR0 A;  2E0X A;  1TF0 A;  1BKE A;  1HK5 A;  2KBZ A;  1TXU A;  4G04 A;  4IW1 A;  4WA6 B;  4ZCG A;  1LNS A;  3NVM A;  4G01 A;  4MBE C;  5GHK A;  1VFI A;  2VUE A;  4E99 A;  3PLA A;  4LUH A;  2Z8I A;  5DQF A;  2XVW A;  4Z69 A;  4LUF A;  1AO6 A;  1UOR A;  2DYM A;  4C31 B;  4FK5 B;  4IW2 A;  5IIX A;  4LA0 A;  3FWB C;  4HGM B;  4N0F D;  2QM6 A;  2BXD A;  5IJF A;  5GIN A;  4BY9 C;  1BJ5 A;  1GNJ A;  3WHQ A;  2BXE A;  2XMO A;  4FIP B;  1IJG A;  1E7B A;  4LB9 A;  2CKX A;  3JQZ A;  4N3Z A;  1HA2 A;  2BXH A;  2V36 A;  1E7G A;  4OTT A;  1O9X A;  1HK3 A;  4S1Y A;  2XSI A;  1J7E A;  1E7F A;  2BXL A;  4BKE A;  4N0U D;  4ZUX V;  1H5W A;  4OT2 A;  3WHR A;  3VQI A;  1BM0 A;  2BXQ A;  5DBY A;  2LOQ A;  3SIU B;  1MIW A;  2DBW A;  2EFD A;  2YDF A;  4ZBQ A;  3LU7 A;  3H3A A;  2BXO A;  2BXA A;  4L8U A;  3W1S A;  2XVQ A;  4TQ0 A;  3V03 A;  3MHS B;  3B9L A;  3M99 C;  5IJE A;  2QHB A;  1E7C A;  2BXG A;  1FOU A;  3LU6 A;  4PO0 A;  2VUF A;  4F5V A;  4L9Q A;  2VDB A;  2EFC A;  4M70 B;  4FJC B;  1HK1 A;  4F5U A;  3GQU A;  3LU8 A;  3B9M A;  4HGK A;  2JUH A;  1HK2 A;  1GNI A;  1H9Z A;  2XVV A;  3NVI A;  2DYO A;  1JNB A;  1MIV A;  5FUO A;  4G03 A;  4J2V A;  1J78 A;  4LB2 A;  4JK4 A;  5IJ5 A;  1LOT A;  2BXN A;  5GIO A;  3G9K D;  2XW0 A;  4DHX B;  1E7A A;  1MA9 A;  3UIV A;  1KW2 A;  2XVU A;  4OTU A;  3KJL A;  5D7G A;  1MIY A;  4ZBR A;  5B5T A;  2BX8 A;  4Z9O A;  2NQO A;  1HK4 A;  3ICX A;  2DBU A;  4ZC6 A;  3A73 A;  5ID7 A;  5IIH A;  1VZS A;  2BXI A;  2Z8J A;  2BXC A;  2OT3 A;  4NAW B;  4TQ1 A;  4GDK B;  4ZBK A;  2BXM A;  3TDL A;  2EFH A;  4L9K A;  2AJE A;  2DBX A;  3A75 A;  4F5S A;  5IFO A;  5GIP A;  1E78 A;  3V09 A;  2QMC A;  2OZB B;  3FNM A;  2EFE A;  5BPK A;  2Z8K A;  1KXP D;  1E7I A;  4K71 A;  4GDL B;  4K2C A;  3JRY A;  2I2Z A;  3H37 A;  2DG5 A;  2XW1 A;  4GG2 A;  2BXB A;  3V08 A;  2BXK A;  4EMX A;  2BXF A;  3SIV B;  2ROH A;  3MHH B;  2I30 A;  2E0Y A;  5IIU A;  3GA9 L;  1NT2 B;  3KIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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