The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
217
|
sequence length |
578
|
structure length |
578
|
Chain Sequence |
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
pubmed doi rcsb |
| molecule keywords |
SERUM ALBUMIN
|
| molecule tags |
Immune system
|
| source organism |
Homo sapiens
|
| total genus |
217
|
| structure length |
578
|
| sequence length |
578
|
| ec nomenclature | |
| pdb deposition date | 2016-01-28 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00273 | Serum_albumin | Serum albumin family |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 | ||
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 | ||
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 | ||
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 | ||
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 | ||
| Mainly Alpha | Orthogonal Bundle | Serum Albumin; Chain A, Domain 1 | Serum Albumin; Chain A, Domain 1 |
#chains in the Genus database with same CATH superfamily 1LOT A; 1HK4 A; 2VUF A; 2I2Z A; 2BXO A; 5DBY A; 5HOZ A; 3CX9 A; 4OT2 A; 2BXI A; 4ZBQ A; 1GNI A; 1HK2 A; 2BXK A; 1TF0 A; 4N0F D; 1E7A A; 3V09 A; 3B9M A; 2BXG A; 4IW1 A; 3JRY A; 1MA9 A; 2VDB A; 4JK4 A; 2BXH A; 1HK3 A; 1AO6 A; 4E99 A; 1N5U A; 2VUE A; 1GNJ A; 3JQZ A; 3V03 A; 2BXQ A; 4K2C A; 4F5V A; 3SQJ A; 1E78 A; 4Z69 A; 3TDL A; 4ZBR A; 1HK5 A; 1E7C A; 1BJ5 A; 1KW2 A; 1BM0 A; 5DQF A; 4EMX A; 4BKE A; 2BXL A; 2I30 A; 2BXE A; 2BXF A; 2YDF A; 1E7B A; 4G03 A; 4L8U A; 5IJF A; 2BXB A; 3A73 A; 4HGM B; 1E7I A; 4F5S A; 5IIH A; 5IJ5 A; 5FUO A; 2XSI A; 4K71 A; 2XW1 A; 1E7E A; 1E7F A; 4LA0 A; 2XVQ A; 2BXM A; 1O9X A; 4IW2 A; 1H9Z A; 5IIU A; 2XW0 A; 2BX8 A; 4LB2 A; 3LU8 A; 3LU6 A; 1J7E A; 2BXC A; 4L9K A; 2XVV A; 1E7H A; 1KXP D; 4S1Y A; 5IJE A; 4HGK A; 1UOR A; 1HK1 A; 4J2V A; 2BXP A; 3V08 A; 4LUF A; 4L9Q A; 3UIV A; 4PO0 A; 1HA2 A; 5ID7 A; 2BXN A; 4F5T A; 5ID9 A; 2XVU A; 2BXD A; 5IFO A; 1E7G A; 2XVW A; 5GHK A; 4OR0 A; 3B9L A; 4LUH A; 4G04 A; 5IIX A; 4N0U D; 1J78 A; 3LU7 A; 1BKE A; 4F5U A; 2BXA A; 4LB9 A; #chains in the Genus database with same CATH topology 1LOT A; 1HK4 A; 2DBW A; 4D7X A; 2DBX A; 2LXS A; 2VUF A; 3H3A A; 4C31 B; 4W4U B; 2I2Z A; 2BXO A; 5DBY A; 1NT2 B; 5HOZ A; 3CX9 A; 2LXT A; 3GQU A; 4FJC B; 5B5T A; 2DG5 A; 4OT2 A; 2BXI A; 4ZBQ A; 1GNI A; 2Z8J A; 1HK2 A; 5BPK A; 2JUH A; 2BXK A; 1TF0 A; 3GQX A; 4N0F D; 1E7A A; 2QHB A; 3V09 A; 2QM6 A; 2ROH A; 1VZS A; 4MBE C; 4ZCG A; 3B9M A; 2BXG A; 4IW1 A; 1MIY A; 3JRY A; 1MA9 A; 2VDB A; 5GIO A; 4FK5 B; 4JK4 A; 4WA6 B; 3H37 A; 2BXH A; 1HK3 A; 4GDX A; 2Z8K A; 1AO6 A; 4E99 A; 1N5U A; 2VUE A; 1GNJ A; 3JQZ A; 4M70 B; 4TQ0 A; 3V03 A; 1MUH A; 2BXQ A; 2QMC A; 4K2C A; 5D7G A; 4F5V A; 3SQJ A; 4N3Z A; 1MUS A; 1E78 A; 4Z69 A; 2Z8I A; 4OTU A; 3TDL A; 1MIV A; 4ZBR A; 4BY9 C; 2LOQ A; 1HK5 A; 2AGH B; 1KDX A; 1E7C A; 4G01 A; 1BJ5 A; 1KW2 A; 1BM0 A; 2DBU A; 4OTT A; 3ECP A; 5DQF A; 3WHQ A; 2NNW A; 4EMX A; 4BKE A; 2BXL A; 2I30 A; 2E0Y A; 3SIU B; 2BXE A; 3NVI A; 2BXF A; 2YDF A; 3SIV B; 1E7B A; 4G03 A; 4L8U A; 1H5W A; 2EFE A; 4GDL B; 2AJE A; 5IJF A; 1MM8 A; 2EFH A; 2DYM A; 3BPJ A; 2BXB A; 4ZC6 A; 3G9K D; 3A75 A; 3A73 A; 4HGM B; 1E7I A; 2LQI A; 4F5S A; 2OZB B; 2GUT A; 5IIH A; 5IJ5 A; 5FUO A; 2XSI A; 4K71 A; 2XW1 A; 1E7E A; 1JNB A; 1E7F A; 2NQO A; 4LA0 A; 2XVQ A; 2BXM A; 1O9X A; 4IW2 A; 3MHS B; 4Z9O A; 1H9Z A; 3WHR A; 5IIU A; 2XW0 A; 3KJL A; 2XMO A; 3PLA A; 2BX8 A; 4LB2 A; 2K0N A; 2KWF A; 5GIN A; 3LU8 A; 3LU6 A; 3NMU A; 2V36 A; 2EFC A; 4DHX B; 1J7E A; 2LQH A; 4ZBK A; 4ZUX V; 2BXC A; 4L9K A; 1TXU A; 2XVV A; 1MIW A; 1FOU A; 2OT3 A; 5GIP A; 1E7H A; 3WHS A; 1KXP D; 4I9O A; 4S1Y A; 5IJE A; 3W1S A; 3MHH B; 3FWC C; 1UOR A; 1HK1 A; 2EFD A; 3FNM A; 3ICX A; 4HGK A; 1SB0 A; 2KBZ A; 3FWB C; 2BXP A; 4J2V A; 3V08 A; 4GDK B; 4LUF A; 4L9Q A; 4DM0 A; 3UIV A; 2E0X A; 2CKX A; 4PO0 A; 3NVK A; 3KIK A; 1HA2 A; 5ID7 A; 2BXN A; 4F5T A; 1IJG A; 2XVU A; 5ID9 A; 2BXD A; 4TQ1 A; 4FIP B; 1E7G A; 2XVW A; 5IFO A; 5GHK A; 4OR0 A; 3B9L A; 4GG2 A; 4LUH A; 4G04 A; 4NAW B; 1VFI A; 5IIX A; 3GA9 L; 4N0U D; 1J78 A; 3LU7 A; 1BKE A; 4F5U A; 3VQI A; 2BXA A; 4LB9 A; 3M99 C; 3NVM A; 1LNS A; 2DYO A; #chains in the Genus database with same CATH homology 1LOT A; 1HK4 A; 2DBW A; 2DBX A; 2VUF A; 3H3A A; 4C31 B; 4W4U B; 2I2Z A; 2BXO A; 5DBY A; 1NT2 B; 5HOZ A; 3CX9 A; 3GQU A; 4FJC B; 5B5T A; 2DG5 A; 4OT2 A; 2BXI A; 4ZBQ A; 1GNI A; 2Z8J A; 1HK2 A; 5BPK A; 2JUH A; 2BXK A; 1TF0 A; 3GQX A; 4N0F D; 1E7A A; 2QHB A; 3V09 A; 2QM6 A; 2ROH A; 1VZS A; 4MBE C; 4ZCG A; 3B9M A; 2BXG A; 4IW1 A; 1MIY A; 3JRY A; 1MA9 A; 2VDB A; 5GIO A; 4FK5 B; 4JK4 A; 4WA6 B; 3H37 A; 2BXH A; 1HK3 A; 4GDX A; 2Z8K A; 1AO6 A; 4E99 A; 1N5U A; 2VUE A; 1GNJ A; 3JQZ A; 4M70 B; 4TQ0 A; 3V03 A; 2BXQ A; 2QMC A; 4K2C A; 5D7G A; 4F5V A; 3SQJ A; 4N3Z A; 1E78 A; 4Z69 A; 2Z8I A; 4OTU A; 3TDL A; 1MIV A; 4ZBR A; 4BY9 C; 2LOQ A; 1HK5 A; 1E7C A; 4G01 A; 1BJ5 A; 1KW2 A; 1BM0 A; 2DBU A; 4OTT A; 5DQF A; 3WHQ A; 2NNW A; 4EMX A; 4BKE A; 2BXL A; 2I30 A; 2E0Y A; 3SIU B; 2BXE A; 3NVI A; 2BXF A; 2YDF A; 3SIV B; 1E7B A; 4G03 A; 4L8U A; 1H5W A; 2EFE A; 4GDL B; 2AJE A; 5IJF A; 2EFH A; 2DYM A; 2BXB A; 4ZC6 A; 3G9K D; 3A75 A; 3A73 A; 4HGM B; 1E7I A; 4F5S A; 2OZB B; 5IIH A; 5IJ5 A; 5FUO A; 2XSI A; 4K71 A; 2XW1 A; 1E7E A; 1JNB A; 1E7F A; 2NQO A; 4LA0 A; 2XVQ A; 2BXM A; 1O9X A; 4IW2 A; 3MHS B; 4Z9O A; 1H9Z A; 3WHR A; 5IIU A; 2XW0 A; 3KJL A; 2XMO A; 3PLA A; 2BX8 A; 4LB2 A; 5GIN A; 3LU8 A; 3LU6 A; 3NMU A; 2V36 A; 2EFC A; 4DHX B; 1J7E A; 4ZBK A; 4ZUX V; 2BXC A; 4L9K A; 1TXU A; 2XVV A; 1MIW A; 1FOU A; 2OT3 A; 5GIP A; 1E7H A; 3WHS A; 1KXP D; 4S1Y A; 5IJE A; 3W1S A; 3MHH B; 3FWC C; 1UOR A; 1HK1 A; 2EFD A; 3FNM A; 3ICX A; 4HGK A; 4J2V A; 2KBZ A; 3FWB C; 2BXP A; 3V08 A; 4GDK B; 4LUF A; 4L9Q A; 3UIV A; 2E0X A; 2CKX A; 4PO0 A; 3NVK A; 3KIK A; 1HA2 A; 5ID7 A; 2BXN A; 4F5T A; 1IJG A; 2XVU A; 5ID9 A; 2BXD A; 4TQ1 A; 4FIP B; 1E7G A; 2XVW A; 5IFO A; 5GHK A; 4OR0 A; 3B9L A; 4GG2 A; 4LUH A; 4G04 A; 4NAW B; 1VFI A; 5IIX A; 3GA9 L; 4N0U D; 1J78 A; 3LU7 A; 1BKE A; 4F5U A; 3VQI A; 2BXA A; 4LB9 A; 3M99 C; 3NVM A; 1LNS A; 2DYO A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
