5FUOA

Extending the half-life of a fab fragment through generation of a humanised anti-human serum albumin (hsa) fv domain: an investigation into the correlation between affinity and serum half-life
Total Genus 217
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
217
sequence length
578
structure length
578
Chain Sequence
SEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Immune system
molecule keywords SERUM ALBUMIN
publication title Extending the Half-Life of a Fab Fragment Through Generation of a Humanized Anti-Human Serum Albumin Fv Domain: An Investigation Into the Correlation between Affinity and Serum Half-Life.
pubmed doi rcsb
source organism Homo sapiens
total genus 217
structure length 578
sequence length 578
ec nomenclature
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00273 Serum_albumin Serum albumin family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA03
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA02
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA04
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA01
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA06
1.10.246.10 Mainly Alpha Orthogonal Bundle Serum Albumin; Chain A, Domain 1 Serum Albumin; Chain A, Domain 1 5fuoA05
2BXNA 4L9KA 5IIXA 4EMXA 4IW2A 5ID7A 1AO6A 1E7AA 2BX8A 1E7IA 1HK2A 5FUOA 2BXFA 4L9QA 4OT2A 4K71A 1HK3A 1KXPD 1LOTA 1J78A 2BXMA 4N0FD 2XVVA 1GNJA 4LA0A 2XVWA 1KW2A 5DQFA 1E7CA 2XW1A 2XSIA 4HGMB 3LU6A 4F5UA 5HOZA 4J2VA 2BXQA 3B9MA 4F5SA 5IJEA 4F5TA 1J7EA 3CX9A 4K2CA 1E7EA 5IFOA 5IIHA 2BXBA 2BXDA 2I2ZA 4G04A 5DBYA 1E7GA 1HK4A 2VUFA 2BXKA 2VUEA 2XVQA 1HA2A 4ZBQA 5ID9A 3JRYA 1O9XA 2BXPA 1HK1A 2I30A 4HGKA 3SQJA 3V09A 2XVUA 5GHKA 4L8UA 2BXGA 1E7BA 4LUHA 1E7FA 5IJ5A 1BJ5A 1MA9A 4E99A 4PO0A 2BXEA 3JQZA 3LU8A 3TDLA 4S1YA 1HK5A 4OR0A 1BKEA 1E7HA 1BM0A 4LB9A 3LU7A 1UORA 2BXIA 3B9LA 2BXCA 2VDBA 3A73A 4F5VA 2XW0A 3UIVA 1H9ZA 4ZBRA 1GNIA 3V03A 4JK4A 4G03A 4BKEA 4LB2A 2BXOA 2YDFA 4LUFA 4N0UD 5IJFA 4Z69A 1N5UA 1E78A 2BXAA 4IW1A 3V08A 5IIUA 1TF0A 2BXLA 2BXHA
chains in the Genus database with same CATH superfamily
2BXNA 5GINA 2CKXA 4L9KA 2LXTA 4I9OA 3FNMA 2QHBA 5IIXA 4EMXA 2Z8KA 3SIUB 2Z8IA 4IW2A 4D7XA 2KBZA 5ID7A 1AO6A 3NMUA 1E7AA 1MUHA 5B5TA 2V36A 2Z8JA 2BX8A 1E7IA 1HK2A 3H37A 3WHQA 2DBUA 5FUOA 2AJEA 2BXFA 1FOUA 2ROHA 4L9QA 4TQ1A 4OT2A 4ZC6A 2KWFA 1NT2B 4K71A 1JNBA 1MIWA 1HK3A 1KXPD 1LOTA 2EFHA 1J78A 2BXMA 2DG5A 2LXSA 4N0FD 2XVVA 1GNJA 4ZBKA 4Z9OA 4LA0A 2XVWA 2GUTA 1KW2A 2DBXA 2QMCA 2QM6A 5DQFA 1E7CA 2XW1A 2XSIA 4HGMB 3LU6A 3MHSB 4F5UA 4GG2A 5HOZA 4J2VA 2LOQA 4TQ0A 3MHHB 1VFIA 1H5WA 2BXQA 3B9MA 4F5SA 5IJEA 1MM8A 4F5TA 1J7EA 3W1SA 3CX9A 4K2CA 1E7EA 5IFOA 1MUSA 5IIHA 4G01A 2BXBA 2BXDA 2EFDA 1KDXA 2OZBB 3WHRA 3PLAA 2I2ZA 2OT3A 2AGHB 4G04A 5DBYA 1E7GA 1HK4A 2NNWA 2VUFA 2BXKA 1MIVA 2VUEA 2XVQA 1HA2A 5D7GA 4OTUA 4ZBQA 5ID9A 2DBWA 3JRYA 1O9XA 2BXPA 1HK1A 2I30A 3GQXA 3VQIA 3WHSA 4HGKA 3SQJA 3V09A 2XVUA 5GHKA 4L8UA 2BXGA 1E7BA 4LUHA 4FIPB 2DYMA 1E7FA 5IJ5A 3NVIA 4BY9C 4FK5B 1BJ5A 3ICXA 1MA9A 3NVMA 4GDXA 4E99A 3H3AA 5GIPA 4PO0A 3KIKA 2BXEA 2E0YA 3JQZA 3LU8A 3TDLA 5GIOA 4S1YA 1IJGA 1HK5A 4GDLB 4OR0A 1BKEA 3FWBC 2DYOA 1E7HA 1BM0A 2XMOA 3M99C 1SB0A 4LB9A 3LU7A 1UORA 4NAWB 2BXIA 1MIYA 2EFEA 2K0NA 3B9LA 4W4UB 2BXCA 2VDBA 3A73A 4F5VA 3GA9L 2JUHA 2XW0A 4WA6B 1H9ZA 3UIVA 4M70B 4ZBRA 1GNIA 3NVKA 4C31B 3V03A 4JK4A 4G03A 2E0XA 1VZSA 4BKEA 3ECPA 4LB2A 2BXOA 4N3ZA 2YDFA 2EFCA 4LUFA 4N0UD 5IJFA 4GDKB 4OTTA 4ZCGA 3KJLA 4FJCB 4Z69A 1N5UA 1TXUA 3SIVB 4DM0A 4DHXB 3A75A 1E78A 2BXAA 4MBEC 1LNSA 4IW1A 3GQUA 3V08A 5BPKA 5IIUA 3BPJA 4ZUXV 1TF0A 2LQHA 3G9KD 2BXLA 2NQOA 2BXHA 2LQIA 3FWCC
chains in the Genus database with same CATH topology
2BXNA 5GINA 2CKXA 4L9KA 3FNMA 2QHBA 5IIXA 4EMXA 2Z8KA 3SIUB 2Z8IA 4IW2A 2KBZA 5ID7A 1AO6A 3NMUA 1E7AA 5B5TA 2V36A 2Z8JA 2BX8A 1E7IA 1HK2A 3H37A 3WHQA 2DBUA 5FUOA 2AJEA 2BXFA 1FOUA 2ROHA 4L9QA 4TQ1A 4OT2A 4ZC6A 1NT2B 4K71A 1JNBA 1MIWA 1HK3A 1KXPD 1LOTA 2EFHA 1J78A 2BXMA 2DG5A 4N0FD 2XVVA 1GNJA 4ZBKA 4Z9OA 4LA0A 2XVWA 1KW2A 2DBXA 2QMCA 2QM6A 5DQFA 1E7CA 2XW1A 2XSIA 4HGMB 3LU6A 3MHSB 4F5UA 4GG2A 5HOZA 4J2VA 2LOQA 4TQ0A 3MHHB 1VFIA 1H5WA 2BXQA 3B9MA 4F5SA 5IJEA 4F5TA 1J7EA 3W1SA 3CX9A 4K2CA 1E7EA 5IFOA 5IIHA 4G01A 2BXBA 2BXDA 2EFDA 2OZBB 3WHRA 3PLAA 2I2ZA 2OT3A 4G04A 5DBYA 1E7GA 1HK4A 2NNWA 2VUFA 2BXKA 1MIVA 2VUEA 2XVQA 1HA2A 5D7GA 4OTUA 4ZBQA 5ID9A 2DBWA 3JRYA 1O9XA 2BXPA 1HK1A 2I30A 3GQXA 3VQIA 3WHSA 4HGKA 3SQJA 3V09A 2XVUA 5GHKA 4L8UA 2BXGA 1E7BA 4LUHA 4FIPB 2DYMA 1E7FA 5IJ5A 3NVIA 4BY9C 4FK5B 1BJ5A 3ICXA 1MA9A 3NVMA 4GDXA 4E99A 3H3AA 5GIPA 4PO0A 3KIKA 2BXEA 2E0YA 3JQZA 3LU8A 3TDLA 5GIOA 4S1YA 1IJGA 1HK5A 4GDLB 4OR0A 1BKEA 3FWBC 2DYOA 1E7HA 1BM0A 2XMOA 3M99C 4LB9A 4NAWB 3LU7A 1UORA 2BXIA 1MIYA 2EFEA 3B9LA 4W4UB 2BXCA 2VDBA 3A73A 4F5VA 3GA9L 2JUHA 2XW0A 4WA6B 1H9ZA 3UIVA 4M70B 4ZBRA 1GNIA 3NVKA 4C31B 3V03A 4JK4A 4G03A 2E0XA 1VZSA 4BKEA 4LB2A 2BXOA 4N3ZA 2YDFA 2EFCA 4LUFA 4N0UD 5IJFA 4GDKB 4OTTA 4ZCGA 3KJLA 4FJCB 4Z69A 1N5UA 1TXUA 3SIVB 4DHXB 3A75A 1E78A 2BXAA 4MBEC 1LNSA 4IW1A 3GQUA 3V08A 5BPKA 5IIUA 4ZUXV 1TF0A 3G9KD 2BXLA 2NQOA 2BXHA 3FWCC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BXN A;  4L9K A;  5IIX A;  4EMX A;  4IW2 A;  5ID7 A;  1AO6 A;  1E7A A;  2BX8 A;  1E7I A;  1HK2 A;  5FUO A;  2BXF A;  4L9Q A;  4OT2 A;  4K71 A;  1HK3 A;  1KXP D;  1LOT A;  1J78 A;  2BXM A;  4N0F D;  2XVV A;  1GNJ A;  4LA0 A;  2XVW A;  1KW2 A;  5DQF A;  1E7C A;  2XW1 A;  2XSI A;  4HGM B;  3LU6 A;  4F5U A;  5HOZ A;  4J2V A;  2BXQ A;  3B9M A;  4F5S A;  5IJE A;  4F5T A;  1J7E A;  3CX9 A;  4K2C A;  1E7E A;  5IFO A;  5IIH A;  2BXB A;  2BXD A;  2I2Z A;  4G04 A;  5DBY A;  1E7G A;  1HK4 A;  2VUF A;  2BXK A;  2VUE A;  2XVQ A;  1HA2 A;  4ZBQ A;  5ID9 A;  3JRY A;  1O9X A;  2BXP A;  1HK1 A;  2I30 A;  4HGK A;  3SQJ A;  3V09 A;  2XVU A;  5GHK A;  4L8U A;  2BXG A;  1E7B A;  4LUH A;  1E7F A;  5IJ5 A;  1BJ5 A;  1MA9 A;  4E99 A;  4PO0 A;  2BXE A;  3JQZ A;  3LU8 A;  3TDL A;  4S1Y A;  1HK5 A;  4OR0 A;  1BKE A;  1E7H A;  1BM0 A;  4LB9 A;  3LU7 A;  1UOR A;  2BXI A;  3B9L A;  2BXC A;  2VDB A;  3A73 A;  4F5V A;  2XW0 A;  3UIV A;  1H9Z A;  4ZBR A;  1GNI A;  3V03 A;  4JK4 A;  4G03 A;  4BKE A;  4LB2 A;  2BXO A;  2YDF A;  4LUF A;  4N0U D;  5IJF A;  4Z69 A;  1N5U A;  1E78 A;  2BXA A;  4IW1 A;  3V08 A;  5IIU A;  1TF0 A;  2BXL A;  2BXH A; 
#chains in the Genus database with same CATH topology
 2BXN A;  5GIN A;  2CKX A;  4L9K A;  2LXT A;  4I9O A;  3FNM A;  2QHB A;  5IIX A;  4EMX A;  2Z8K A;  3SIU B;  2Z8I A;  4IW2 A;  4D7X A;  2KBZ A;  5ID7 A;  1AO6 A;  3NMU A;  1E7A A;  1MUH A;  5B5T A;  2V36 A;  2Z8J A;  2BX8 A;  1E7I A;  1HK2 A;  3H37 A;  3WHQ A;  2DBU A;  5FUO A;  2AJE A;  2BXF A;  1FOU A;  2ROH A;  4L9Q A;  4TQ1 A;  4OT2 A;  4ZC6 A;  2KWF A;  1NT2 B;  4K71 A;  1JNB A;  1MIW A;  1HK3 A;  1KXP D;  1LOT A;  2EFH A;  1J78 A;  2BXM A;  2DG5 A;  2LXS A;  4N0F D;  2XVV A;  1GNJ A;  4ZBK A;  4Z9O A;  4LA0 A;  2XVW A;  2GUT A;  1KW2 A;  2DBX A;  2QMC A;  2QM6 A;  5DQF A;  1E7C A;  2XW1 A;  2XSI A;  4HGM B;  3LU6 A;  3MHS B;  4F5U A;  4GG2 A;  5HOZ A;  4J2V A;  2LOQ A;  4TQ0 A;  3MHH B;  1VFI A;  1H5W A;  2BXQ A;  3B9M A;  4F5S A;  5IJE A;  1MM8 A;  4F5T A;  1J7E A;  3W1S A;  3CX9 A;  4K2C A;  1E7E A;  5IFO A;  1MUS A;  5IIH A;  4G01 A;  2BXB A;  2BXD A;  2EFD A;  1KDX A;  2OZB B;  3WHR A;  3PLA A;  2I2Z A;  2OT3 A;  2AGH B;  4G04 A;  5DBY A;  1E7G A;  1HK4 A;  2NNW A;  2VUF A;  2BXK A;  1MIV A;  2VUE A;  2XVQ A;  1HA2 A;  5D7G A;  4OTU A;  4ZBQ A;  5ID9 A;  2DBW A;  3JRY A;  1O9X A;  2BXP A;  1HK1 A;  2I30 A;  3GQX A;  3VQI A;  3WHS A;  4HGK A;  3SQJ A;  3V09 A;  2XVU A;  5GHK A;  4L8U A;  2BXG A;  1E7B A;  4LUH A;  4FIP B;  2DYM A;  1E7F A;  5IJ5 A;  3NVI A;  4BY9 C;  4FK5 B;  1BJ5 A;  3ICX A;  1MA9 A;  3NVM A;  4GDX A;  4E99 A;  3H3A A;  5GIP A;  4PO0 A;  3KIK A;  2BXE A;  2E0Y A;  3JQZ A;  3LU8 A;  3TDL A;  5GIO A;  4S1Y A;  1IJG A;  1HK5 A;  4GDL B;  4OR0 A;  1BKE A;  3FWB C;  2DYO A;  1E7H A;  1BM0 A;  2XMO A;  3M99 C;  1SB0 A;  4LB9 A;  3LU7 A;  1UOR A;  4NAW B;  2BXI A;  1MIY A;  2EFE A;  2K0N A;  3B9L A;  4W4U B;  2BXC A;  2VDB A;  3A73 A;  4F5V A;  3GA9 L;  2JUH A;  2XW0 A;  4WA6 B;  1H9Z A;  3UIV A;  4M70 B;  4ZBR A;  1GNI A;  3NVK A;  4C31 B;  3V03 A;  4JK4 A;  4G03 A;  2E0X A;  1VZS A;  4BKE A;  3ECP A;  4LB2 A;  2BXO A;  4N3Z A;  2YDF A;  2EFC A;  4LUF A;  4N0U D;  5IJF A;  4GDK B;  4OTT A;  4ZCG A;  3KJL A;  4FJC B;  4Z69 A;  1N5U A;  1TXU A;  3SIV B;  4DM0 A;  4DHX B;  3A75 A;  1E78 A;  2BXA A;  4MBE C;  1LNS A;  4IW1 A;  3GQU A;  3V08 A;  5BPK A;  5IIU A;  3BPJ A;  4ZUX V;  1TF0 A;  2LQH A;  3G9K D;  2BXL A;  2NQO A;  2BXH A;  2LQI A;  3FWC C; 
#chains in the Genus database with same CATH homology
 2BXN A;  5GIN A;  2CKX A;  4L9K A;  3FNM A;  2QHB A;  5IIX A;  4EMX A;  2Z8K A;  3SIU B;  2Z8I A;  4IW2 A;  2KBZ A;  5ID7 A;  1AO6 A;  3NMU A;  1E7A A;  5B5T A;  2V36 A;  2Z8J A;  2BX8 A;  1E7I A;  1HK2 A;  3H37 A;  3WHQ A;  2DBU A;  5FUO A;  2AJE A;  2BXF A;  1FOU A;  2ROH A;  4L9Q A;  4TQ1 A;  4OT2 A;  4ZC6 A;  1NT2 B;  4K71 A;  1JNB A;  1MIW A;  1HK3 A;  1KXP D;  1LOT A;  2EFH A;  1J78 A;  2BXM A;  2DG5 A;  4N0F D;  2XVV A;  1GNJ A;  4ZBK A;  4Z9O A;  4LA0 A;  2XVW A;  1KW2 A;  2DBX A;  2QMC A;  2QM6 A;  5DQF A;  1E7C A;  2XW1 A;  2XSI A;  4HGM B;  3LU6 A;  3MHS B;  4F5U A;  4GG2 A;  5HOZ A;  4J2V A;  2LOQ A;  4TQ0 A;  3MHH B;  1VFI A;  1H5W A;  2BXQ A;  3B9M A;  4F5S A;  5IJE A;  4F5T A;  1J7E A;  3W1S A;  3CX9 A;  4K2C A;  1E7E A;  5IFO A;  5IIH A;  4G01 A;  2BXB A;  2BXD A;  2EFD A;  2OZB B;  3WHR A;  3PLA A;  2I2Z A;  2OT3 A;  4G04 A;  5DBY A;  1E7G A;  1HK4 A;  2NNW A;  2VUF A;  2BXK A;  1MIV A;  2VUE A;  2XVQ A;  1HA2 A;  5D7G A;  4OTU A;  4ZBQ A;  5ID9 A;  2DBW A;  3JRY A;  1O9X A;  2BXP A;  1HK1 A;  2I30 A;  3GQX A;  3VQI A;  3WHS A;  4HGK A;  3SQJ A;  3V09 A;  2XVU A;  5GHK A;  4L8U A;  2BXG A;  1E7B A;  4LUH A;  4FIP B;  2DYM A;  1E7F A;  5IJ5 A;  3NVI A;  4BY9 C;  4FK5 B;  1BJ5 A;  3ICX A;  1MA9 A;  3NVM A;  4GDX A;  4E99 A;  3H3A A;  5GIP A;  4PO0 A;  3KIK A;  2BXE A;  2E0Y A;  3JQZ A;  3LU8 A;  3TDL A;  5GIO A;  4S1Y A;  1IJG A;  1HK5 A;  4GDL B;  4OR0 A;  1BKE A;  3FWB C;  2DYO A;  1E7H A;  1BM0 A;  2XMO A;  3M99 C;  4LB9 A;  4NAW B;  3LU7 A;  1UOR A;  2BXI A;  1MIY A;  2EFE A;  3B9L A;  4W4U B;  2BXC A;  2VDB A;  3A73 A;  4F5V A;  3GA9 L;  2JUH A;  2XW0 A;  4WA6 B;  1H9Z A;  3UIV A;  4M70 B;  4ZBR A;  1GNI A;  3NVK A;  4C31 B;  3V03 A;  4JK4 A;  4G03 A;  2E0X A;  1VZS A;  4BKE A;  4LB2 A;  2BXO A;  4N3Z A;  2YDF A;  2EFC A;  4LUF A;  4N0U D;  5IJF A;  4GDK B;  4OTT A;  4ZCG A;  3KJL A;  4FJC B;  4Z69 A;  1N5U A;  1TXU A;  3SIV B;  4DHX B;  3A75 A;  1E78 A;  2BXA A;  4MBE C;  1LNS A;  4IW1 A;  3GQU A;  3V08 A;  5BPK A;  5IIU A;  4ZUX V;  1TF0 A;  3G9K D;  2BXL A;  2NQO A;  2BXH A;  3FWC C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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