1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
4LR2A 2XR9A 3Q3QA 1HQAA 1ELXA 2ANHA 4LQYA 3KD8A 4GTWA 3OT9A 1Y6VA 3NKQA 4CXKA 4KJGA 4UPIA 2IFYA 4ZG7A 1Y7AA 4LR8A 1URBA 1ZEDA 3NKNA 4GTXA 3B5QA 2D1GA 1AUKA 1N2LA 5L0KA 2GLQA 2VQRA 3SZYA 5LQQA 3ED4A 2W5TA 4LRBA 4LRCA 1KH7A 3NKRA 4UORA 4UOOA 3BDFA 2W8SA 5LRNA 1ALJA 1ANJA 5EGHA 3UN2A 4UPHA 4LRDA 5K4PA 5DLVA 1EQJA 2W5QA 2XRGA 3A52A 4NWXA 5IJQA 3UN3A 1AJDA 3NVLA 3NKPA 2W5XA 3UNYA 5C66A 3IGZB 2G9YA 3DPCA 3NKMA 4LREA 3BDGB 1ALIA 2W5WA 1KH9A 3NKOA 1SHNA 2IUCB 3T01A 1ED8A 5DLTA 1HJKA 4KAVA 3IGYB 1KHNA 3WAWA 5IJSA 4MHXA 3LXQA 3UN5A 2GA3A 3WAVA 3T00A 4UPKA 3WBHA 1AJAA 1KH5A 3TG0A 4CYRA 4KJDA 3M7VA 3MK1A 2X98A 1K7HA 1O98A 4YR1A 1EW8A 1KHKA 2RH6A 2W5VA 4MIVA 1ANIA 5L0EA 3MK2A 1AJBA 3TWZA 5HRTA 1KH4A 1O99A 4KM4A 5INHA 1HDHA 1P49A 3TX0A 1AJCA 4QAXA 3BDHA 1ALHA 5L0BA 4CXSA 2GSOA 4FDJA 5DLWA 4LRAA 4ZGAA 5LIAA 2GSNA 1SHQA 5GOVA 4B56A 5LRMA 4LR7A 4LR9A 4ZG6A 4FDIA 1EI6A 1KHLA 2W5SA 1ED9A 3M8YA 1E2SP 3E2DA 4MY4A 5GRRA 3WAYA 1EW2A 1EW9A 4ZG9A 3WAXA 3M8ZA 2QZUA 4UOPA 4GTZA 4CXUA 3IDDA 3DYCA 1EJJA 3CMRA 3MK0A 2GSUA 1E1ZP 1ZEBA 1ZEFA 5EGEA 2W8DA 4UPLA 1URAA 1ELZA 1E3CP 2ZKTA 4CYSA 1E33P 4TN0A 1KHJA 1ALKA 1FSUA 5TJ3A 4KAYA 5KXAA 4NWJA 4LRFA 4N7TA 3BDGA 1ELYA 3SZZA 3M8WA 3UO0A 2W5RA 5AJ9A 1N2KA 2IUCA 3T02A 1B8JA 4GTYA
chains in the Genus database with same CATH superfamily
4LR2A 2XR9A 3Q3QA 1HQAA 1ELXA 2ANHA 4LQYA 3KD8A 4GTWA 3OT9A 1Y6VA 3NKQA 4CXKA 4KJGA 4UPIA 2IFYA 4ZG7A 1Y7AA 4LR8A 1URBA 1ZEDA 3NKNA 4GTXA 3B5QA 2D1GA 1AUKA 1N2LA 5L0KA 2GLQA 2VQRA 3SZYA 5LQQA 3ED4A 2W5TA 4LRBA 4LRCA 1KH7A 3NKRA 4UORA 4UOOA 3BDFA 2W8SA 5LRNA 1ALJA 1ANJA 5EGHA 3UN2A 4UPHA 4LRDA 5K4PA 5DLVA 1EQJA 2W5QA 2XRGA 3A52A 4NWXA 5IJQA 3UN3A 1AJDA 3NVLA 3NKPA 2W5XA 3UNYA 5C66A 3IGZB 2G9YA 3DPCA 3NKMA 4LREA 3BDGB 1ALIA 2W5WA 1KH9A 3NKOA 1SHNA 2IUCB 3T01A 1ED8A 5DLTA 1HJKA 4KAVA 3IGYB 1KHNA 3WAWA 5IJSA 4MHXA 3LXQA 3UN5A 2GA3A 3WAVA 3T00A 4UPKA 3WBHA 1AJAA 1KH5A 3TG0A 4CYRA 4KJDA 3M7VA 3MK1A 2X98A 1K7HA 1O98A 4YR1A 1EW8A 1KHKA 2RH6A 2W5VA 4MIVA 1ANIA 5L0EA 3MK2A 1AJBA 3TWZA 5HRTA 1KH4A 1O99A 4KM4A 5INHA 1HDHA 1P49A 3TX0A 1AJCA 4QAXA 3BDHA 1ALHA 5L0BA 4CXSA 2GSOA 4FDJA 5DLWA 4LRAA 4ZGAA 5LIAA 2GSNA 1SHQA 5GOVA 4B56A 5LRMA 4LR7A 4LR9A 4ZG6A 4FDIA 1EI6A 1KHLA 2W5SA 1ED9A 3M8YA 1E2SP 3E2DA 4MY4A 5GRRA 3WAYA 1EW2A 1EW9A 4ZG9A 3WAXA 3M8ZA 2QZUA 4UOPA 4GTZA 4CXUA 3IDDA 3DYCA 1EJJA 3CMRA 3MK0A 2GSUA 1E1ZP 1ZEBA 1ZEFA 5EGEA 2W8DA 4UPLA 1URAA 1ELZA 1E3CP 2ZKTA 4CYSA 1E33P 4TN0A 1KHJA 1ALKA 1FSUA 5TJ3A 4KAYA 5KXAA 4NWJA 4LRFA 4N7TA 3BDGA 1ELYA 3SZZA 3M8WA 3UO0A 2W5RA 5AJ9A 1N2KA 2IUCA 3T02A 1B8JA 4GTYA
chains in the Genus database with same CATH topology
4LR2A 2XR9A 3Q3QA 1HQAA 1ELXA 2ANHA 4LQYA 3KD8A 4GTWA 3OT9A 1Y6VA 3NKQA 4CXKA 4KJGA 4UPIA 2IFYA 4ZG7A 1Y7AA 4LR8A 1URBA 1ZEDA 3NKNA 4GTXA 3B5QA 2D1GA 1AUKA 1N2LA 5L0KA 2GLQA 2VQRA 3SZYA 5LQQA 3ED4A 2W5TA 4LRBA 4LRCA 1KH7A 3NKRA 4UORA 4UOOA 3BDFA 2W8SA 5LRNA 1ALJA 1ANJA 5EGHA 3UN2A 4UPHA 4LRDA 5K4PA 5DLVA 1EQJA 2W5QA 2XRGA 3A52A 4NWXA 5IJQA 3UN3A 1AJDA 3NVLA 3NKPA 2W5XA 3UNYA 5C66A 3IGZB 2G9YA 3DPCA 3NKMA 4LREA 3BDGB 1ALIA 2W5WA 1KH9A 3NKOA 1SHNA 2IUCB 3T01A 1ED8A 5DLTA 1HJKA 4KAVA 3IGYB 1KHNA 3WAWA 5IJSA 4MHXA 3LXQA 3UN5A 2GA3A 3WAVA 3T00A 4UPKA 3WBHA 1AJAA 1KH5A 3TG0A 4CYRA 4KJDA 3M7VA 3MK1A 2X98A 1K7HA 1O98A 4YR1A 1EW8A 1KHKA 2RH6A 2W5VA 4MIVA 1ANIA 5L0EA 3MK2A 1AJBA 3TWZA 5HRTA 1KH4A 1O99A 4KM4A 5INHA 1HDHA 1P49A 3TX0A 1AJCA 4QAXA 3BDHA 1ALHA 5L0BA 4CXSA 2GSOA 4FDJA 5DLWA 4LRAA 4ZGAA 5LIAA 2GSNA 1SHQA 5GOVA 4B56A 5LRMA 4LR7A 4LR9A 4ZG6A 4FDIA 1EI6A 1KHLA 2W5SA 1ED9A 3M8YA 1E2SP 3E2DA 4MY4A 5GRRA 3WAYA 1EW2A 1EW9A 4ZG9A 3WAXA 3M8ZA 2QZUA 4UOPA 4GTZA 4CXUA 3IDDA 3DYCA 1EJJA 3CMRA 3MK0A 2GSUA 1E1ZP 1ZEBA 1ZEFA 5EGEA 2W8DA 4UPLA 1URAA 1ELZA 1E3CP 2ZKTA 4CYSA 1E33P 4TN0A 1KHJA 1ALKA 1FSUA 5TJ3A 4KAYA 5KXAA 4NWJA 4LRFA 4N7TA 3BDGA 1ELYA 3SZZA 3M8WA 3UO0A 2W5RA 5AJ9A 1N2KA 2IUCA 3T02A 1B8JA 4GTYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR2 A;  2XR9 A;  3Q3Q A;  1HQA A;  1ELX A;  2ANH A;  4LQY A;  3KD8 A;  4GTW A;  3OT9 A;  1Y6V A;  3NKQ A;  4CXK A;  4KJG A;  4UPI A;  2IFY A;  4ZG7 A;  1Y7A A;  4LR8 A;  1URB A;  1ZED A;  3NKN A;  4GTX A;  3B5Q A;  2D1G A;  1AUK A;  1N2L A;  5L0K A;  2GLQ A;  2VQR A;  3SZY A;  5LQQ A;  3ED4 A;  2W5T A;  4LRB A;  4LRC A;  1KH7 A;  3NKR A;  4UOR A;  4UOO A;  3BDF A;  2W8S A;  5LRN A;  1ALJ A;  1ANJ A;  5EGH A;  3UN2 A;  4UPH A;  4LRD A;  5K4P A;  5DLV A;  1EQJ A;  2W5Q A;  2XRG A;  3A52 A;  4NWX A;  5IJQ A;  3UN3 A;  1AJD A;  3NVL A;  3NKP A;  2W5X A;  3UNY A;  5C66 A;  3IGZ B;  2G9Y A;  3DPC A;  3NKM A;  4LRE A;  3BDG B;  1ALI A;  2W5W A;  1KH9 A;  3NKO A;  1SHN A;  2IUC B;  3T01 A;  1ED8 A;  5DLT A;  1HJK A;  4KAV A;  3IGY B;  1KHN A;  3WAW A;  5IJS A;  4MHX A;  3LXQ A;  3UN5 A;  2GA3 A;  3WAV A;  3T00 A;  4UPK A;  3WBH A;  1AJA A;  1KH5 A;  3TG0 A;  4CYR A;  4KJD A;  3M7V A;  3MK1 A;  2X98 A;  1K7H A;  1O98 A;  4YR1 A;  1EW8 A;  1KHK A;  2RH6 A;  2W5V A;  4MIV A;  1ANI A;  5L0E A;  3MK2 A;  1AJB A;  3TWZ A;  5HRT A;  1KH4 A;  1O99 A;  4KM4 A;  5INH A;  1HDH A;  1P49 A;  3TX0 A;  1AJC A;  4QAX A;  3BDH A;  1ALH A;  5L0B A;  4CXS A;  2GSO A;  4FDJ A;  5DLW A;  4LRA A;  4ZGA A;  5LIA A;  2GSN A;  1SHQ A;  5GOV A;  4B56 A;  5LRM A;  4LR7 A;  4LR9 A;  4ZG6 A;  4FDI A;  1EI6 A;  1KHL A;  2W5S A;  1ED9 A;  3M8Y A;  1E2S P;  3E2D A;  4MY4 A;  5GRR A;  3WAY A;  1EW2 A;  1EW9 A;  4ZG9 A;  3WAX A;  3M8Z A;  2QZU A;  4UOP A;  4GTZ A;  4CXU A;  3IDD A;  3DYC A;  1EJJ A;  3CMR A;  3MK0 A;  2GSU A;  1E1Z P;  1ZEB A;  1ZEF A;  5EGE A;  2W8D A;  4UPL A;  1URA A;  1ELZ A;  1E3C P;  2ZKT A;  4CYS A;  1E33 P;  4TN0 A;  1KHJ A;  1ALK A;  1FSU A;  5TJ3 A;  4KAY A;  5KXA A;  4NWJ A;  4LRF A;  4N7T A;  3BDG A;  1ELY A;  3SZZ A;  3M8W A;  3UO0 A;  2W5R A;  5AJ9 A;  1N2K A;  2IUC A;  3T02 A;  1B8J A;  4GTY A; 
#chains in the Genus database with same CATH topology
 4LR2 A;  2XR9 A;  3Q3Q A;  1HQA A;  1ELX A;  2ANH A;  4LQY A;  3KD8 A;  4GTW A;  3OT9 A;  1Y6V A;  3NKQ A;  4CXK A;  4KJG A;  4UPI A;  2IFY A;  4ZG7 A;  1Y7A A;  4LR8 A;  1URB A;  1ZED A;  3NKN A;  4GTX A;  3B5Q A;  2D1G A;  1AUK A;  1N2L A;  5L0K A;  2GLQ A;  2VQR A;  3SZY A;  5LQQ A;  3ED4 A;  2W5T A;  4LRB A;  4LRC A;  1KH7 A;  3NKR A;  4UOR A;  4UOO A;  3BDF A;  2W8S A;  5LRN A;  1ALJ A;  1ANJ A;  5EGH A;  3UN2 A;  4UPH A;  4LRD A;  5K4P A;  5DLV A;  1EQJ A;  2W5Q A;  2XRG A;  3A52 A;  4NWX A;  5IJQ A;  3UN3 A;  1AJD A;  3NVL A;  3NKP A;  2W5X A;  3UNY A;  5C66 A;  3IGZ B;  2G9Y A;  3DPC A;  3NKM A;  4LRE A;  3BDG B;  1ALI A;  2W5W A;  1KH9 A;  3NKO A;  1SHN A;  2IUC B;  3T01 A;  1ED8 A;  5DLT A;  1HJK A;  4KAV A;  3IGY B;  1KHN A;  3WAW A;  5IJS A;  4MHX A;  3LXQ A;  3UN5 A;  2GA3 A;  3WAV A;  3T00 A;  4UPK A;  3WBH A;  1AJA A;  1KH5 A;  3TG0 A;  4CYR A;  4KJD A;  3M7V A;  3MK1 A;  2X98 A;  1K7H A;  1O98 A;  4YR1 A;  1EW8 A;  1KHK A;  2RH6 A;  2W5V A;  4MIV A;  1ANI A;  5L0E A;  3MK2 A;  1AJB A;  3TWZ A;  5HRT A;  1KH4 A;  1O99 A;  4KM4 A;  5INH A;  1HDH A;  1P49 A;  3TX0 A;  1AJC A;  4QAX A;  3BDH A;  1ALH A;  5L0B A;  4CXS A;  2GSO A;  4FDJ A;  5DLW A;  4LRA A;  4ZGA A;  5LIA A;  2GSN A;  1SHQ A;  5GOV A;  4B56 A;  5LRM A;  4LR7 A;  4LR9 A;  4ZG6 A;  4FDI A;  1EI6 A;  1KHL A;  2W5S A;  1ED9 A;  3M8Y A;  1E2S P;  3E2D A;  4MY4 A;  5GRR A;  3WAY A;  1EW2 A;  1EW9 A;  4ZG9 A;  3WAX A;  3M8Z A;  2QZU A;  4UOP A;  4GTZ A;  4CXU A;  3IDD A;  3DYC A;  1EJJ A;  3CMR A;  3MK0 A;  2GSU A;  1E1Z P;  1ZEB A;  1ZEF A;  5EGE A;  2W8D A;  4UPL A;  1URA A;  1ELZ A;  1E3C P;  2ZKT A;  4CYS A;  1E33 P;  4TN0 A;  1KHJ A;  1ALK A;  1FSU A;  5TJ3 A;  4KAY A;  5KXA A;  4NWJ A;  4LRF A;  4N7T A;  3BDG A;  1ELY A;  3SZZ A;  3M8W A;  3UO0 A;  2W5R A;  5AJ9 A;  1N2K A;  2IUC A;  3T02 A;  1B8J A;  4GTY A; 
#chains in the Genus database with same CATH homology
 4LR2 A;  2XR9 A;  3Q3Q A;  1HQA A;  1ELX A;  2ANH A;  4LQY A;  3KD8 A;  4GTW A;  3OT9 A;  1Y6V A;  3NKQ A;  4CXK A;  4KJG A;  4UPI A;  2IFY A;  4ZG7 A;  1Y7A A;  4LR8 A;  1URB A;  1ZED A;  3NKN A;  4GTX A;  3B5Q A;  2D1G A;  1AUK A;  1N2L A;  5L0K A;  2GLQ A;  2VQR A;  3SZY A;  5LQQ A;  3ED4 A;  2W5T A;  4LRB A;  4LRC A;  1KH7 A;  3NKR A;  4UOR A;  4UOO A;  3BDF A;  2W8S A;  5LRN A;  1ALJ A;  1ANJ A;  5EGH A;  3UN2 A;  4UPH A;  4LRD A;  5K4P A;  5DLV A;  1EQJ A;  2W5Q A;  2XRG A;  3A52 A;  4NWX A;  5IJQ A;  3UN3 A;  1AJD A;  3NVL A;  3NKP A;  2W5X A;  3UNY A;  5C66 A;  3IGZ B;  2G9Y A;  3DPC A;  3NKM A;  4LRE A;  3BDG B;  1ALI A;  2W5W A;  1KH9 A;  3NKO A;  1SHN A;  2IUC B;  3T01 A;  1ED8 A;  5DLT A;  1HJK A;  4KAV A;  3IGY B;  1KHN A;  3WAW A;  5IJS A;  4MHX A;  3LXQ A;  3UN5 A;  2GA3 A;  3WAV A;  3T00 A;  4UPK A;  3WBH A;  1AJA A;  1KH5 A;  3TG0 A;  4CYR A;  4KJD A;  3M7V A;  3MK1 A;  2X98 A;  1K7H A;  1O98 A;  4YR1 A;  1EW8 A;  1KHK A;  2RH6 A;  2W5V A;  4MIV A;  1ANI A;  5L0E A;  3MK2 A;  1AJB A;  3TWZ A;  5HRT A;  1KH4 A;  1O99 A;  4KM4 A;  5INH A;  1HDH A;  1P49 A;  3TX0 A;  1AJC A;  4QAX A;  3BDH A;  1ALH A;  5L0B A;  4CXS A;  2GSO A;  4FDJ A;  5DLW A;  4LRA A;  4ZGA A;  5LIA A;  2GSN A;  1SHQ A;  5GOV A;  4B56 A;  5LRM A;  4LR7 A;  4LR9 A;  4ZG6 A;  4FDI A;  1EI6 A;  1KHL A;  2W5S A;  1ED9 A;  3M8Y A;  1E2S P;  3E2D A;  4MY4 A;  5GRR A;  3WAY A;  1EW2 A;  1EW9 A;  4ZG9 A;  3WAX A;  3M8Z A;  2QZU A;  4UOP A;  4GTZ A;  4CXU A;  3IDD A;  3DYC A;  1EJJ A;  3CMR A;  3MK0 A;  2GSU A;  1E1Z P;  1ZEB A;  1ZEF A;  5EGE A;  2W8D A;  4UPL A;  1URA A;  1ELZ A;  1E3C P;  2ZKT A;  4CYS A;  1E33 P;  4TN0 A;  1KHJ A;  1ALK A;  1FSU A;  5TJ3 A;  4KAY A;  5KXA A;  4NWJ A;  4LRF A;  4N7T A;  3BDG A;  1ELY A;  3SZZ A;  3M8W A;  3UO0 A;  2W5R A;  5AJ9 A;  1N2K A;  2IUC A;  3T02 A;  1B8J A;  4GTY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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