1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
source organism Escherichia coli
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
1P49A 1ED9A 5L0BA 4UPKA 3MK2A 4MIVA 1EJJA 4LRDA 4CXUA 1AJCA 2ANHA 4ZGAA 5L0KA 1ED8A 1ANIA 1HJKA 4LRCA 2GLQA 3NKNA 3B5QA 2W5WA 1AJAA 1N2KA 1ELZA 4KM4A 1Y7AA 5K4PA 1KHLA 1EW9A 1AJBA 1KH4A 4LRAA 3SZYA 5LIAA 2ZKTA 4LR2A 4NWJA 4CYSA 1EI6A 2W5QA 1KH7A 5LQQA 1K7HA 3BDHA 5HRTA 1URBA 3UN5A 3BDGB 3NKQA 4LRFA 2GA3A 3IDDA 4FDJA 1ALKA 1HDHA 1ANJA 5IJQA 3UN2A 5GRRA 3TG0A 2W5RA 3M7VA 2W8DA 3ED4A 3NKOA 1AJDA 2VQRA 5DLWA 1ELXA 4QAXA 5TJ3A 4CXKA 4N7TA 4GTXA 4TN0A 1E2SP 3NKRA 4ZG6A 3WAYA 4ZG9A 2W5XA 4KAVA 4UOOA 3E2DA 3UNYA 3IGYB 5DLVA 1EQJA 2X98A 3T01A 3M8YA 3M8WA 2GSNA 3A52A 5EGHA 4GTWA 5EGEA 4YR1A 1ALJA 5C66A 3M8ZA 2W5VA 3MK0A 5L0EA 3T02A 4NWXA 2W5SA 1O98A 4KJDA 1EW8A 1FSUA 3T00A 2W5TA 4UPHA 4KJGA 4GTZA 5GOVA 4LQYA 3Q3QA 3BDGA 2QZUA 3CMRA 4MY4A 4LR9A 4LR8A 1ALHA 2RH6A 5LRNA 3TWZA 4CXSA 5INHA 2IUCB 1E3CP 1URAA 4LR7A 3WAWA 4GTYA 2GSOA 4LRBA 1KH9A 4UOPA 3BDFA 2XRGA 5LRMA 1ELYA 4UORA 1KHKA 3IGZB 1Y6VA 1KHNA 1AUKA 1E1ZP 1B8JA 1SHNA 3OT9A 1O99A 3DPCA 5IJSA 1ZEDA 3NKMA 1EW2A 2IFYA 3LXQA 2GSUA 2XR9A 2D1GA 4CYRA 5KXAA 4ZG7A 3WAVA 4UPIA 3NVLA 1E33P 1KHJA 2G9YA 1N2LA 1ZEBA 4KAYA 1SHQA 1ALIA 1ZEFA 4LREA 3UO0A 3MK1A 3UN3A 4MHXA 1KH5A 5AJ9A 1HQAA 5DLTA 3SZZA 3WAXA 3TX0A 3WBHA 3DYCA 4FDIA 4B56A 4UPLA 3NKPA 2IUCA 3KD8A 2W8SA
chains in the Genus database with same CATH superfamily
1P49A 1ED9A 5L0BA 4UPKA 3MK2A 4MIVA 1EJJA 4LRDA 4CXUA 1AJCA 2ANHA 4ZGAA 5L0KA 1ED8A 1ANIA 1HJKA 4LRCA 2GLQA 3NKNA 3B5QA 2W5WA 1AJAA 1N2KA 1ELZA 4KM4A 1Y7AA 5K4PA 1KHLA 1EW9A 1AJBA 1KH4A 4LRAA 3SZYA 5LIAA 2ZKTA 4LR2A 4NWJA 4CYSA 1EI6A 2W5QA 1KH7A 5LQQA 1K7HA 3BDHA 5HRTA 1URBA 3UN5A 3BDGB 3NKQA 4LRFA 2GA3A 3IDDA 4FDJA 1ALKA 1HDHA 1ANJA 5IJQA 3UN2A 5GRRA 3TG0A 2W5RA 3M7VA 2W8DA 3ED4A 3NKOA 1AJDA 2VQRA 5DLWA 1ELXA 4QAXA 5TJ3A 4CXKA 4N7TA 4GTXA 4TN0A 1E2SP 3NKRA 4ZG6A 3WAYA 4ZG9A 2W5XA 4KAVA 4UOOA 3E2DA 3UNYA 3IGYB 5DLVA 1EQJA 2X98A 3T01A 3M8YA 3M8WA 2GSNA 3A52A 5EGHA 4GTWA 5EGEA 4YR1A 1ALJA 5C66A 3M8ZA 2W5VA 3MK0A 5L0EA 3T02A 4NWXA 2W5SA 1O98A 4KJDA 1EW8A 1FSUA 3T00A 2W5TA 4UPHA 4KJGA 4GTZA 5GOVA 4LQYA 3Q3QA 3BDGA 2QZUA 3CMRA 4MY4A 4LR9A 4LR8A 1ALHA 2RH6A 5LRNA 3TWZA 4CXSA 5INHA 2IUCB 1E3CP 1URAA 4LR7A 3WAWA 4GTYA 2GSOA 4LRBA 1KH9A 4UOPA 3BDFA 2XRGA 5LRMA 1ELYA 4UORA 1KHKA 3IGZB 1Y6VA 1KHNA 1AUKA 1E1ZP 1B8JA 1SHNA 3OT9A 1O99A 3DPCA 5IJSA 1ZEDA 3NKMA 1EW2A 2IFYA 3LXQA 2GSUA 2XR9A 2D1GA 4CYRA 5KXAA 4ZG7A 3WAVA 4UPIA 3NVLA 1E33P 1KHJA 2G9YA 1N2LA 1ZEBA 4KAYA 1SHQA 1ALIA 1ZEFA 4LREA 3UO0A 3MK1A 3UN3A 4MHXA 1KH5A 5AJ9A 1HQAA 5DLTA 3SZZA 3WAXA 3TX0A 3WBHA 3DYCA 4FDIA 4B56A 4UPLA 3NKPA 2IUCA 3KD8A 2W8SA
chains in the Genus database with same CATH topology
1P49A 1ED9A 5L0BA 4UPKA 3MK2A 4MIVA 1EJJA 4LRDA 4CXUA 1AJCA 2ANHA 4ZGAA 5L0KA 1ED8A 1ANIA 1HJKA 4LRCA 2GLQA 3NKNA 3B5QA 2W5WA 1AJAA 1N2KA 1ELZA 4KM4A 1Y7AA 5K4PA 1KHLA 1EW9A 1AJBA 1KH4A 4LRAA 3SZYA 5LIAA 2ZKTA 4LR2A 4NWJA 4CYSA 1EI6A 2W5QA 1KH7A 5LQQA 1K7HA 3BDHA 5HRTA 1URBA 3UN5A 3BDGB 3NKQA 4LRFA 2GA3A 3IDDA 4FDJA 1ALKA 1HDHA 1ANJA 5IJQA 3UN2A 5GRRA 3TG0A 2W5RA 3M7VA 2W8DA 3ED4A 3NKOA 1AJDA 2VQRA 5DLWA 1ELXA 4QAXA 5TJ3A 4CXKA 4N7TA 4GTXA 4TN0A 1E2SP 3NKRA 4ZG6A 3WAYA 4ZG9A 2W5XA 4KAVA 4UOOA 3E2DA 3UNYA 3IGYB 5DLVA 1EQJA 2X98A 3T01A 3M8YA 3M8WA 2GSNA 3A52A 5EGHA 4GTWA 5EGEA 4YR1A 1ALJA 5C66A 3M8ZA 2W5VA 3MK0A 5L0EA 3T02A 4NWXA 2W5SA 1O98A 4KJDA 1EW8A 1FSUA 3T00A 2W5TA 4UPHA 4KJGA 4GTZA 5GOVA 4LQYA 3Q3QA 3BDGA 2QZUA 3CMRA 4MY4A 4LR9A 4LR8A 1ALHA 2RH6A 5LRNA 3TWZA 4CXSA 5INHA 2IUCB 1E3CP 1URAA 4LR7A 3WAWA 4GTYA 2GSOA 4LRBA 1KH9A 4UOPA 3BDFA 2XRGA 5LRMA 1ELYA 4UORA 1KHKA 3IGZB 1Y6VA 1KHNA 1AUKA 1E1ZP 1B8JA 1SHNA 3OT9A 1O99A 3DPCA 5IJSA 1ZEDA 3NKMA 1EW2A 2IFYA 3LXQA 2GSUA 2XR9A 2D1GA 4CYRA 5KXAA 4ZG7A 3WAVA 4UPIA 3NVLA 1E33P 1KHJA 2G9YA 1N2LA 1ZEBA 4KAYA 1SHQA 1ALIA 1ZEFA 4LREA 3UO0A 3MK1A 3UN3A 4MHXA 1KH5A 5AJ9A 1HQAA 5DLTA 3SZZA 3WAXA 3TX0A 3WBHA 3DYCA 4FDIA 4B56A 4UPLA 3NKPA 2IUCA 3KD8A 2W8SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1P49 A;  1ED9 A;  5L0B A;  4UPK A;  3MK2 A;  4MIV A;  1EJJ A;  4LRD A;  4CXU A;  1AJC A;  2ANH A;  4ZGA A;  5L0K A;  1ED8 A;  1ANI A;  1HJK A;  4LRC A;  2GLQ A;  3NKN A;  3B5Q A;  2W5W A;  1AJA A;  1N2K A;  1ELZ A;  4KM4 A;  1Y7A A;  5K4P A;  1KHL A;  1EW9 A;  1AJB A;  1KH4 A;  4LRA A;  3SZY A;  5LIA A;  2ZKT A;  4LR2 A;  4NWJ A;  4CYS A;  1EI6 A;  2W5Q A;  1KH7 A;  5LQQ A;  1K7H A;  3BDH A;  5HRT A;  1URB A;  3UN5 A;  3BDG B;  3NKQ A;  4LRF A;  2GA3 A;  3IDD A;  4FDJ A;  1ALK A;  1HDH A;  1ANJ A;  5IJQ A;  3UN2 A;  5GRR A;  3TG0 A;  2W5R A;  3M7V A;  2W8D A;  3ED4 A;  3NKO A;  1AJD A;  2VQR A;  5DLW A;  1ELX A;  4QAX A;  5TJ3 A;  4CXK A;  4N7T A;  4GTX A;  4TN0 A;  1E2S P;  3NKR A;  4ZG6 A;  3WAY A;  4ZG9 A;  2W5X A;  4KAV A;  4UOO A;  3E2D A;  3UNY A;  3IGY B;  5DLV A;  1EQJ A;  2X98 A;  3T01 A;  3M8Y A;  3M8W A;  2GSN A;  3A52 A;  5EGH A;  4GTW A;  5EGE A;  4YR1 A;  1ALJ A;  5C66 A;  3M8Z A;  2W5V A;  3MK0 A;  5L0E A;  3T02 A;  4NWX A;  2W5S A;  1O98 A;  4KJD A;  1EW8 A;  1FSU A;  3T00 A;  2W5T A;  4UPH A;  4KJG A;  4GTZ A;  5GOV A;  4LQY A;  3Q3Q A;  3BDG A;  2QZU A;  3CMR A;  4MY4 A;  4LR9 A;  4LR8 A;  1ALH A;  2RH6 A;  5LRN A;  3TWZ A;  4CXS A;  5INH A;  2IUC B;  1E3C P;  1URA A;  4LR7 A;  3WAW A;  4GTY A;  2GSO A;  4LRB A;  1KH9 A;  4UOP A;  3BDF A;  2XRG A;  5LRM A;  1ELY A;  4UOR A;  1KHK A;  3IGZ B;  1Y6V A;  1KHN A;  1AUK A;  1E1Z P;  1B8J A;  1SHN A;  3OT9 A;  1O99 A;  3DPC A;  5IJS A;  1ZED A;  3NKM A;  1EW2 A;  2IFY A;  3LXQ A;  2GSU A;  2XR9 A;  2D1G A;  4CYR A;  5KXA A;  4ZG7 A;  3WAV A;  4UPI A;  3NVL A;  1E33 P;  1KHJ A;  2G9Y A;  1N2L A;  1ZEB A;  4KAY A;  1SHQ A;  1ALI A;  1ZEF A;  4LRE A;  3UO0 A;  3MK1 A;  3UN3 A;  4MHX A;  1KH5 A;  5AJ9 A;  1HQA A;  5DLT A;  3SZZ A;  3WAX A;  3TX0 A;  3WBH A;  3DYC A;  4FDI A;  4B56 A;  4UPL A;  3NKP A;  2IUC A;  3KD8 A;  2W8S A; 
#chains in the Genus database with same CATH topology
 1P49 A;  1ED9 A;  5L0B A;  4UPK A;  3MK2 A;  4MIV A;  1EJJ A;  4LRD A;  4CXU A;  1AJC A;  2ANH A;  4ZGA A;  5L0K A;  1ED8 A;  1ANI A;  1HJK A;  4LRC A;  2GLQ A;  3NKN A;  3B5Q A;  2W5W A;  1AJA A;  1N2K A;  1ELZ A;  4KM4 A;  1Y7A A;  5K4P A;  1KHL A;  1EW9 A;  1AJB A;  1KH4 A;  4LRA A;  3SZY A;  5LIA A;  2ZKT A;  4LR2 A;  4NWJ A;  4CYS A;  1EI6 A;  2W5Q A;  1KH7 A;  5LQQ A;  1K7H A;  3BDH A;  5HRT A;  1URB A;  3UN5 A;  3BDG B;  3NKQ A;  4LRF A;  2GA3 A;  3IDD A;  4FDJ A;  1ALK A;  1HDH A;  1ANJ A;  5IJQ A;  3UN2 A;  5GRR A;  3TG0 A;  2W5R A;  3M7V A;  2W8D A;  3ED4 A;  3NKO A;  1AJD A;  2VQR A;  5DLW A;  1ELX A;  4QAX A;  5TJ3 A;  4CXK A;  4N7T A;  4GTX A;  4TN0 A;  1E2S P;  3NKR A;  4ZG6 A;  3WAY A;  4ZG9 A;  2W5X A;  4KAV A;  4UOO A;  3E2D A;  3UNY A;  3IGY B;  5DLV A;  1EQJ A;  2X98 A;  3T01 A;  3M8Y A;  3M8W A;  2GSN A;  3A52 A;  5EGH A;  4GTW A;  5EGE A;  4YR1 A;  1ALJ A;  5C66 A;  3M8Z A;  2W5V A;  3MK0 A;  5L0E A;  3T02 A;  4NWX A;  2W5S A;  1O98 A;  4KJD A;  1EW8 A;  1FSU A;  3T00 A;  2W5T A;  4UPH A;  4KJG A;  4GTZ A;  5GOV A;  4LQY A;  3Q3Q A;  3BDG A;  2QZU A;  3CMR A;  4MY4 A;  4LR9 A;  4LR8 A;  1ALH A;  2RH6 A;  5LRN A;  3TWZ A;  4CXS A;  5INH A;  2IUC B;  1E3C P;  1URA A;  4LR7 A;  3WAW A;  4GTY A;  2GSO A;  4LRB A;  1KH9 A;  4UOP A;  3BDF A;  2XRG A;  5LRM A;  1ELY A;  4UOR A;  1KHK A;  3IGZ B;  1Y6V A;  1KHN A;  1AUK A;  1E1Z P;  1B8J A;  1SHN A;  3OT9 A;  1O99 A;  3DPC A;  5IJS A;  1ZED A;  3NKM A;  1EW2 A;  2IFY A;  3LXQ A;  2GSU A;  2XR9 A;  2D1G A;  4CYR A;  5KXA A;  4ZG7 A;  3WAV A;  4UPI A;  3NVL A;  1E33 P;  1KHJ A;  2G9Y A;  1N2L A;  1ZEB A;  4KAY A;  1SHQ A;  1ALI A;  1ZEF A;  4LRE A;  3UO0 A;  3MK1 A;  3UN3 A;  4MHX A;  1KH5 A;  5AJ9 A;  1HQA A;  5DLT A;  3SZZ A;  3WAX A;  3TX0 A;  3WBH A;  3DYC A;  4FDI A;  4B56 A;  4UPL A;  3NKP A;  2IUC A;  3KD8 A;  2W8S A; 
#chains in the Genus database with same CATH homology
 1P49 A;  1ED9 A;  5L0B A;  4UPK A;  3MK2 A;  4MIV A;  1EJJ A;  4LRD A;  4CXU A;  1AJC A;  2ANH A;  4ZGA A;  5L0K A;  1ED8 A;  1ANI A;  1HJK A;  4LRC A;  2GLQ A;  3NKN A;  3B5Q A;  2W5W A;  1AJA A;  1N2K A;  1ELZ A;  4KM4 A;  1Y7A A;  5K4P A;  1KHL A;  1EW9 A;  1AJB A;  1KH4 A;  4LRA A;  3SZY A;  5LIA A;  2ZKT A;  4LR2 A;  4NWJ A;  4CYS A;  1EI6 A;  2W5Q A;  1KH7 A;  5LQQ A;  1K7H A;  3BDH A;  5HRT A;  1URB A;  3UN5 A;  3BDG B;  3NKQ A;  4LRF A;  2GA3 A;  3IDD A;  4FDJ A;  1ALK A;  1HDH A;  1ANJ A;  5IJQ A;  3UN2 A;  5GRR A;  3TG0 A;  2W5R A;  3M7V A;  2W8D A;  3ED4 A;  3NKO A;  1AJD A;  2VQR A;  5DLW A;  1ELX A;  4QAX A;  5TJ3 A;  4CXK A;  4N7T A;  4GTX A;  4TN0 A;  1E2S P;  3NKR A;  4ZG6 A;  3WAY A;  4ZG9 A;  2W5X A;  4KAV A;  4UOO A;  3E2D A;  3UNY A;  3IGY B;  5DLV A;  1EQJ A;  2X98 A;  3T01 A;  3M8Y A;  3M8W A;  2GSN A;  3A52 A;  5EGH A;  4GTW A;  5EGE A;  4YR1 A;  1ALJ A;  5C66 A;  3M8Z A;  2W5V A;  3MK0 A;  5L0E A;  3T02 A;  4NWX A;  2W5S A;  1O98 A;  4KJD A;  1EW8 A;  1FSU A;  3T00 A;  2W5T A;  4UPH A;  4KJG A;  4GTZ A;  5GOV A;  4LQY A;  3Q3Q A;  3BDG A;  2QZU A;  3CMR A;  4MY4 A;  4LR9 A;  4LR8 A;  1ALH A;  2RH6 A;  5LRN A;  3TWZ A;  4CXS A;  5INH A;  2IUC B;  1E3C P;  1URA A;  4LR7 A;  3WAW A;  4GTY A;  2GSO A;  4LRB A;  1KH9 A;  4UOP A;  3BDF A;  2XRG A;  5LRM A;  1ELY A;  4UOR A;  1KHK A;  3IGZ B;  1Y6V A;  1KHN A;  1AUK A;  1E1Z P;  1B8J A;  1SHN A;  3OT9 A;  1O99 A;  3DPC A;  5IJS A;  1ZED A;  3NKM A;  1EW2 A;  2IFY A;  3LXQ A;  2GSU A;  2XR9 A;  2D1G A;  4CYR A;  5KXA A;  4ZG7 A;  3WAV A;  4UPI A;  3NVL A;  1E33 P;  1KHJ A;  2G9Y A;  1N2L A;  1ZEB A;  4KAY A;  1SHQ A;  1ALI A;  1ZEF A;  4LRE A;  3UO0 A;  3MK1 A;  3UN3 A;  4MHX A;  1KH5 A;  5AJ9 A;  1HQA A;  5DLT A;  3SZZ A;  3WAX A;  3TX0 A;  3WBH A;  3DYC A;  4FDI A;  4B56 A;  4UPL A;  3NKP A;  2IUC A;  3KD8 A;  2W8S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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