1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 162
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
b'TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
2X98A 5LRNA 5GRRA 2W5XA 3MK2A 5DLVA 1KHJA 3NKRA 3IGYB 1KH9A 4LQYA 4UORA 3E2DA 4CXKA 2XRGA 4ZG7A 4ZGAA 1KH7A 1K7HA 1ZEFA 4LR7A 1O99A 3UO0A 5DLTA 4UOOA 1URAA 1B8JA 1ELZA 3WAYA 1EW8A 2GLQA 4KJDA 1KH5A 3NVLA 1EQJA 1ANIA 5K4PA 3NKOA 3UN5A 3UNYA 3WAVA 4UPIA 1EJJA 4UOPA 5GOVA 3M7VA 1ELXA 4LR8A 4CXSA 4LR2A 1E33P 1ALHA 3M8ZA 4UPHA 5HRTA 1ZEBA 1ZEDA 5L0BA 1AJCA 1ALJA 3A52A 2RH6A 4UPKA 3T02A 5IJSA 4YR1A 4NWJA 2W5WA 4NWXA 5IJQA 5INHA 5C66A 3IGZB 3NKMA 4LRAA 3TG0A 4QAXA 1HDHA 5KXAA 1KH4A 5EGHA 1ED9A 5LRMA 1AJAA 4LRCA 4LRDA 4KM4A 4UPLA 3M8WA 2W5QA 2D1GA 3Q3QA 1E1ZP 4FDIA 3NKNA 3SZYA 1Y6VA 3NKQA 3KD8A 3UN2A 4GTYA 4CXUA 3TX0A 1AUKA 4MIVA 4ZG6A 1O98A 3WAXA 2GA3A 4KJGA 4CYSA 4MY4A 1EI6A 1E2SP 1P49A 5LQQA 2W5VA 1N2KA 2VQRA 4LRBA 4CYRA 3NKPA 2GSOA 4N7TA 4ZG9A 1ALIA 3MK0A 1HJKA 2ANHA 3BDGB 2W5SA 3BDGA 2ZKTA 5TJ3A 3T01A 5AJ9A 5L0KA 2IUCA 5DLWA 5LIAA 4MHXA 1E3CP 1N2LA 3BDHA 2XR9A 1EW2A 2GSUA 3UN3A 5L0EA 3OT9A 3SZZA 4TN0A 3DYCA 4KAYA 3WAWA 1AJBA 3IDDA 4GTZA 2IFYA 1ANJA 3CMRA 1KHLA 4LREA 1KHKA 2W5RA 1EW9A 3WBHA 2G9YA 3TWZA 1ELYA 3BDFA 3LXQA 1AJDA 4FDJA 3T00A 3MK1A 2W8SA 4KAVA 4LRFA 1URBA 2GSNA 3M8YA 1Y7AA 4GTWA 4B56A 2QZUA 3B5QA 1ALKA 4GTXA 1FSUA 2IUCB 1SHQA 1SHNA 1ED8A 2W5TA 3DPCA 3ED4A 4LR9A 2W8DA 5EGEA 1HQAA 1KHNA
chains in the Genus database with same CATH superfamily
2X98A 5LRNA 5GRRA 2W5XA 3MK2A 5DLVA 1KHJA 3NKRA 3IGYB 1KH9A 4LQYA 4UORA 3E2DA 4CXKA 2XRGA 4ZG7A 4ZGAA 1KH7A 1K7HA 1ZEFA 4LR7A 1O99A 3UO0A 5DLTA 4UOOA 1URAA 1B8JA 1ELZA 3WAYA 1EW8A 2GLQA 4KJDA 1KH5A 3NVLA 1EQJA 1ANIA 5K4PA 3NKOA 3UN5A 3UNYA 3WAVA 4UPIA 1EJJA 4UOPA 5GOVA 3M7VA 1ELXA 4LR8A 4CXSA 4LR2A 1E33P 1ALHA 3M8ZA 4UPHA 5HRTA 1ZEBA 1ZEDA 5L0BA 1AJCA 1ALJA 3A52A 2RH6A 4UPKA 3T02A 5IJSA 4YR1A 4NWJA 2W5WA 4NWXA 5IJQA 5INHA 5C66A 3IGZB 3NKMA 4LRAA 3TG0A 4QAXA 1HDHA 5KXAA 1KH4A 5EGHA 1ED9A 5LRMA 1AJAA 4LRCA 4LRDA 4KM4A 4UPLA 3M8WA 2W5QA 2D1GA 3Q3QA 1E1ZP 4FDIA 3NKNA 3SZYA 1Y6VA 3NKQA 3KD8A 3UN2A 4GTYA 4CXUA 3TX0A 1AUKA 4MIVA 4ZG6A 1O98A 3WAXA 2GA3A 4KJGA 4CYSA 4MY4A 1EI6A 1E2SP 1P49A 5LQQA 2W5VA 1N2KA 2VQRA 4LRBA 4CYRA 3NKPA 2GSOA 4N7TA 4ZG9A 1ALIA 3MK0A 1HJKA 2ANHA 3BDGB 2W5SA 3BDGA 2ZKTA 5TJ3A 3T01A 5AJ9A 5L0KA 2IUCA 5DLWA 5LIAA 4MHXA 1E3CP 1N2LA 3BDHA 2XR9A 1EW2A 2GSUA 3UN3A 5L0EA 3OT9A 3SZZA 4TN0A 3DYCA 4KAYA 3WAWA 1AJBA 3IDDA 4GTZA 2IFYA 1ANJA 3CMRA 1KHLA 4LREA 1KHKA 2W5RA 1EW9A 3WBHA 2G9YA 3TWZA 1ELYA 3BDFA 3LXQA 1AJDA 4FDJA 3T00A 3MK1A 2W8SA 4KAVA 4LRFA 1URBA 2GSNA 3M8YA 1Y7AA 4GTWA 4B56A 2QZUA 3B5QA 1ALKA 4GTXA 1FSUA 2IUCB 1SHQA 1SHNA 1ED8A 2W5TA 3DPCA 3ED4A 4LR9A 2W8DA 5EGEA 1HQAA 1KHNA
chains in the Genus database with same CATH topology
2X98A 5LRNA 5GRRA 2W5XA 3MK2A 5DLVA 1KHJA 3NKRA 3IGYB 1KH9A 4LQYA 4UORA 3E2DA 4CXKA 2XRGA 4ZG7A 4ZGAA 1KH7A 1K7HA 1ZEFA 4LR7A 1O99A 3UO0A 5DLTA 4UOOA 1URAA 1B8JA 1ELZA 3WAYA 1EW8A 2GLQA 4KJDA 1KH5A 3NVLA 1EQJA 1ANIA 5K4PA 3NKOA 3UN5A 3UNYA 3WAVA 4UPIA 1EJJA 4UOPA 5GOVA 3M7VA 1ELXA 4LR8A 4CXSA 4LR2A 1E33P 1ALHA 3M8ZA 4UPHA 5HRTA 1ZEBA 1ZEDA 5L0BA 1AJCA 1ALJA 3A52A 2RH6A 4UPKA 3T02A 5IJSA 4YR1A 4NWJA 2W5WA 4NWXA 5IJQA 5INHA 5C66A 3IGZB 3NKMA 4LRAA 3TG0A 4QAXA 1HDHA 5KXAA 1KH4A 5EGHA 1ED9A 5LRMA 1AJAA 4LRCA 4LRDA 4KM4A 4UPLA 3M8WA 2W5QA 2D1GA 3Q3QA 1E1ZP 4FDIA 3NKNA 3SZYA 1Y6VA 3NKQA 3KD8A 3UN2A 4GTYA 4CXUA 3TX0A 1AUKA 4MIVA 4ZG6A 1O98A 3WAXA 2GA3A 4KJGA 4CYSA 4MY4A 1EI6A 1E2SP 1P49A 5LQQA 2W5VA 1N2KA 2VQRA 4LRBA 4CYRA 3NKPA 2GSOA 4N7TA 4ZG9A 1ALIA 3MK0A 1HJKA 2ANHA 3BDGB 2W5SA 3BDGA 2ZKTA 5TJ3A 3T01A 5AJ9A 5L0KA 2IUCA 5DLWA 5LIAA 4MHXA 1E3CP 1N2LA 3BDHA 2XR9A 1EW2A 2GSUA 3UN3A 5L0EA 3OT9A 3SZZA 4TN0A 3DYCA 4KAYA 3WAWA 1AJBA 3IDDA 4GTZA 2IFYA 1ANJA 3CMRA 1KHLA 4LREA 1KHKA 2W5RA 1EW9A 3WBHA 2G9YA 3TWZA 1ELYA 3BDFA 3LXQA 1AJDA 4FDJA 3T00A 3MK1A 2W8SA 4KAVA 4LRFA 1URBA 2GSNA 3M8YA 1Y7AA 4GTWA 4B56A 2QZUA 3B5QA 1ALKA 4GTXA 1FSUA 2IUCB 1SHQA 1SHNA 1ED8A 2W5TA 3DPCA 3ED4A 4LR9A 2W8DA 5EGEA 1HQAA 1KHNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2X98 A;  5LRN A;  5GRR A;  2W5X A;  3MK2 A;  5DLV A;  1KHJ A;  3NKR A;  3IGY B;  1KH9 A;  4LQY A;  4UOR A;  3E2D A;  4CXK A;  2XRG A;  4ZG7 A;  4ZGA A;  1KH7 A;  1K7H A;  1ZEF A;  4LR7 A;  1O99 A;  3UO0 A;  5DLT A;  4UOO A;  1URA A;  1B8J A;  1ELZ A;  3WAY A;  1EW8 A;  2GLQ A;  4KJD A;  1KH5 A;  3NVL A;  1EQJ A;  1ANI A;  5K4P A;  3NKO A;  3UN5 A;  3UNY A;  3WAV A;  4UPI A;  1EJJ A;  4UOP A;  5GOV A;  3M7V A;  1ELX A;  4LR8 A;  4CXS A;  4LR2 A;  1E33 P;  1ALH A;  3M8Z A;  4UPH A;  5HRT A;  1ZEB A;  1ZED A;  5L0B A;  1AJC A;  1ALJ A;  3A52 A;  2RH6 A;  4UPK A;  3T02 A;  5IJS A;  4YR1 A;  4NWJ A;  2W5W A;  4NWX A;  5IJQ A;  5INH A;  5C66 A;  3IGZ B;  3NKM A;  4LRA A;  3TG0 A;  4QAX A;  1HDH A;  5KXA A;  1KH4 A;  5EGH A;  1ED9 A;  5LRM A;  1AJA A;  4LRC A;  4LRD A;  4KM4 A;  4UPL A;  3M8W A;  2W5Q A;  2D1G A;  3Q3Q A;  1E1Z P;  4FDI A;  3NKN A;  3SZY A;  1Y6V A;  3NKQ A;  3KD8 A;  3UN2 A;  4GTY A;  4CXU A;  3TX0 A;  1AUK A;  4MIV A;  4ZG6 A;  1O98 A;  3WAX A;  2GA3 A;  4KJG A;  4CYS A;  4MY4 A;  1EI6 A;  1E2S P;  1P49 A;  5LQQ A;  2W5V A;  1N2K A;  2VQR A;  4LRB A;  4CYR A;  3NKP A;  2GSO A;  4N7T A;  4ZG9 A;  1ALI A;  3MK0 A;  1HJK A;  2ANH A;  3BDG B;  2W5S A;  3BDG A;  2ZKT A;  5TJ3 A;  3T01 A;  5AJ9 A;  5L0K A;  2IUC A;  5DLW A;  5LIA A;  4MHX A;  1E3C P;  1N2L A;  3BDH A;  2XR9 A;  1EW2 A;  2GSU A;  3UN3 A;  5L0E A;  3OT9 A;  3SZZ A;  4TN0 A;  3DYC A;  4KAY A;  3WAW A;  1AJB A;  3IDD A;  4GTZ A;  2IFY A;  1ANJ A;  3CMR A;  1KHL A;  4LRE A;  1KHK A;  2W5R A;  1EW9 A;  3WBH A;  2G9Y A;  3TWZ A;  1ELY A;  3BDF A;  3LXQ A;  1AJD A;  4FDJ A;  3T00 A;  3MK1 A;  2W8S A;  4KAV A;  4LRF A;  1URB A;  2GSN A;  3M8Y A;  1Y7A A;  4GTW A;  4B56 A;  2QZU A;  3B5Q A;  1ALK A;  4GTX A;  1FSU A;  2IUC B;  1SHQ A;  1SHN A;  1ED8 A;  2W5T A;  3DPC A;  3ED4 A;  4LR9 A;  2W8D A;  5EGE A;  1HQA A;  1KHN A; 
#chains in the Genus database with same CATH topology
 2X98 A;  5LRN A;  5GRR A;  2W5X A;  3MK2 A;  5DLV A;  1KHJ A;  3NKR A;  3IGY B;  1KH9 A;  4LQY A;  4UOR A;  3E2D A;  4CXK A;  2XRG A;  4ZG7 A;  4ZGA A;  1KH7 A;  1K7H A;  1ZEF A;  4LR7 A;  1O99 A;  3UO0 A;  5DLT A;  4UOO A;  1URA A;  1B8J A;  1ELZ A;  3WAY A;  1EW8 A;  2GLQ A;  4KJD A;  1KH5 A;  3NVL A;  1EQJ A;  1ANI A;  5K4P A;  3NKO A;  3UN5 A;  3UNY A;  3WAV A;  4UPI A;  1EJJ A;  4UOP A;  5GOV A;  3M7V A;  1ELX A;  4LR8 A;  4CXS A;  4LR2 A;  1E33 P;  1ALH A;  3M8Z A;  4UPH A;  5HRT A;  1ZEB A;  1ZED A;  5L0B A;  1AJC A;  1ALJ A;  3A52 A;  2RH6 A;  4UPK A;  3T02 A;  5IJS A;  4YR1 A;  4NWJ A;  2W5W A;  4NWX A;  5IJQ A;  5INH A;  5C66 A;  3IGZ B;  3NKM A;  4LRA A;  3TG0 A;  4QAX A;  1HDH A;  5KXA A;  1KH4 A;  5EGH A;  1ED9 A;  5LRM A;  1AJA A;  4LRC A;  4LRD A;  4KM4 A;  4UPL A;  3M8W A;  2W5Q A;  2D1G A;  3Q3Q A;  1E1Z P;  4FDI A;  3NKN A;  3SZY A;  1Y6V A;  3NKQ A;  3KD8 A;  3UN2 A;  4GTY A;  4CXU A;  3TX0 A;  1AUK A;  4MIV A;  4ZG6 A;  1O98 A;  3WAX A;  2GA3 A;  4KJG A;  4CYS A;  4MY4 A;  1EI6 A;  1E2S P;  1P49 A;  5LQQ A;  2W5V A;  1N2K A;  2VQR A;  4LRB A;  4CYR A;  3NKP A;  2GSO A;  4N7T A;  4ZG9 A;  1ALI A;  3MK0 A;  1HJK A;  2ANH A;  3BDG B;  2W5S A;  3BDG A;  2ZKT A;  5TJ3 A;  3T01 A;  5AJ9 A;  5L0K A;  2IUC A;  5DLW A;  5LIA A;  4MHX A;  1E3C P;  1N2L A;  3BDH A;  2XR9 A;  1EW2 A;  2GSU A;  3UN3 A;  5L0E A;  3OT9 A;  3SZZ A;  4TN0 A;  3DYC A;  4KAY A;  3WAW A;  1AJB A;  3IDD A;  4GTZ A;  2IFY A;  1ANJ A;  3CMR A;  1KHL A;  4LRE A;  1KHK A;  2W5R A;  1EW9 A;  3WBH A;  2G9Y A;  3TWZ A;  1ELY A;  3BDF A;  3LXQ A;  1AJD A;  4FDJ A;  3T00 A;  3MK1 A;  2W8S A;  4KAV A;  4LRF A;  1URB A;  2GSN A;  3M8Y A;  1Y7A A;  4GTW A;  4B56 A;  2QZU A;  3B5Q A;  1ALK A;  4GTX A;  1FSU A;  2IUC B;  1SHQ A;  1SHN A;  1ED8 A;  2W5T A;  3DPC A;  3ED4 A;  4LR9 A;  2W8D A;  5EGE A;  1HQA A;  1KHN A; 
#chains in the Genus database with same CATH homology
 2X98 A;  5LRN A;  5GRR A;  2W5X A;  3MK2 A;  5DLV A;  1KHJ A;  3NKR A;  3IGY B;  1KH9 A;  4LQY A;  4UOR A;  3E2D A;  4CXK A;  2XRG A;  4ZG7 A;  4ZGA A;  1KH7 A;  1K7H A;  1ZEF A;  4LR7 A;  1O99 A;  3UO0 A;  5DLT A;  4UOO A;  1URA A;  1B8J A;  1ELZ A;  3WAY A;  1EW8 A;  2GLQ A;  4KJD A;  1KH5 A;  3NVL A;  1EQJ A;  1ANI A;  5K4P A;  3NKO A;  3UN5 A;  3UNY A;  3WAV A;  4UPI A;  1EJJ A;  4UOP A;  5GOV A;  3M7V A;  1ELX A;  4LR8 A;  4CXS A;  4LR2 A;  1E33 P;  1ALH A;  3M8Z A;  4UPH A;  5HRT A;  1ZEB A;  1ZED A;  5L0B A;  1AJC A;  1ALJ A;  3A52 A;  2RH6 A;  4UPK A;  3T02 A;  5IJS A;  4YR1 A;  4NWJ A;  2W5W A;  4NWX A;  5IJQ A;  5INH A;  5C66 A;  3IGZ B;  3NKM A;  4LRA A;  3TG0 A;  4QAX A;  1HDH A;  5KXA A;  1KH4 A;  5EGH A;  1ED9 A;  5LRM A;  1AJA A;  4LRC A;  4LRD A;  4KM4 A;  4UPL A;  3M8W A;  2W5Q A;  2D1G A;  3Q3Q A;  1E1Z P;  4FDI A;  3NKN A;  3SZY A;  1Y6V A;  3NKQ A;  3KD8 A;  3UN2 A;  4GTY A;  4CXU A;  3TX0 A;  1AUK A;  4MIV A;  4ZG6 A;  1O98 A;  3WAX A;  2GA3 A;  4KJG A;  4CYS A;  4MY4 A;  1EI6 A;  1E2S P;  1P49 A;  5LQQ A;  2W5V A;  1N2K A;  2VQR A;  4LRB A;  4CYR A;  3NKP A;  2GSO A;  4N7T A;  4ZG9 A;  1ALI A;  3MK0 A;  1HJK A;  2ANH A;  3BDG B;  2W5S A;  3BDG A;  2ZKT A;  5TJ3 A;  3T01 A;  5AJ9 A;  5L0K A;  2IUC A;  5DLW A;  5LIA A;  4MHX A;  1E3C P;  1N2L A;  3BDH A;  2XR9 A;  1EW2 A;  2GSU A;  3UN3 A;  5L0E A;  3OT9 A;  3SZZ A;  4TN0 A;  3DYC A;  4KAY A;  3WAW A;  1AJB A;  3IDD A;  4GTZ A;  2IFY A;  1ANJ A;  3CMR A;  1KHL A;  4LRE A;  1KHK A;  2W5R A;  1EW9 A;  3WBH A;  2G9Y A;  3TWZ A;  1ELY A;  3BDF A;  3LXQ A;  1AJD A;  4FDJ A;  3T00 A;  3MK1 A;  2W8S A;  4KAV A;  4LRF A;  1URB A;  2GSN A;  3M8Y A;  1Y7A A;  4GTW A;  4B56 A;  2QZU A;  3B5Q A;  1ALK A;  4GTX A;  1FSU A;  2IUC B;  1SHQ A;  1SHN A;  1ED8 A;  2W5T A;  3DPC A;  3ED4 A;  4LR9 A;  2W8D A;  5EGE A;  1HQA A;  1KHN A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...