1ALHA

Kinetics and crystal structure of a mutant e. coli alkaline phosphatase (asp-369-->asn): a mechanism involving one zinc per active site
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTANHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase (phosphoric monoester)
molecule keywords ALKALINE PHOSPHATASE
publication title Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
pubmed rcsb
source organism Escherichia coli
total genus 149
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1994-08-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alhA00
1ANJA 3M7VA 2XR9A 2W8SA 4CXKA 4LRAA 3WAVA 4KJDA 4LRCA 3TG0A 1AUKA 2W5VA 5LRNA 3UN5A 2W5TA 5AJ9A 3WBHA 2QZUA 1HJKA 5K4PA 4LRFA 3A52A 4NWJA 1ZEFA 2GSOA 3IGZB 3NKRA 4GTYA 4NWXA 3UN3A 1EW9A 2IUCB 4UOOA 3NKOA 1E3CP 5DLTA 1ZEBA 1SHQA 5HRTA 1KHLA 4KAVA 2GSNA 4UPIA 3B5QA 3TX0A 1URAA 4UPLA 4LRDA 1ALKA 2W5WA 5EGHA 3SZYA 3T02A 4KJGA 5L0BA 3CMRA 3BDHA 2ANHA 1AJDA 1EW8A 5KXAA 4LRBA 1ALIA 4ZG6A 1HQAA 1ALJA 4ZGAA 1URBA 2RH6A 5LIAA 1Y7AA 4MIVA 5IJSA 5LQQA 1KH7A 3NKMA 1KHKA 3E2DA 3IDDA 4MHXA 5IJQA 4KM4A 4CYRA 3BDGA 2W5RA 3NVLA 3UN2A 4ZG9A 2W8DA 3WAYA 5INHA 2VQRA 2GLQA 4N7TA 3SZZA 3NKQA 3NKPA 1O99A 4QAXA 3TWZA 2W5QA 3DPCA 3UO0A 3M8YA 5L0EA 4LQYA 1P49A 1EI6A 4CYSA 5C66A 3T00A 1EQJA 3DYCA 4FDJA 4UOPA 1KH9A 4MY4A 4GTZA 5TJ3A 4LR8A 2IFYA 1ED8A 3M8ZA 1KHJA 4KAYA 4LR2A 3Q3QA 5GRRA 5L0KA 1ELXA 3MK2A 3BDGB 1HDHA 1EW2A 5EGEA 5DLVA 4YR1A 1KH4A 3BDFA 2GA3A 3MK1A 4ZG7A 5LRMA 2W5SA 1FSUA 2G9YA 3IGYB 4UPHA 3WAWA 5GOVA 2GSUA 3MK0A 4GTWA 1K7HA 1AJCA 1ZEDA 1ALHA 1SHNA 5DLWA 4CXSA 4LR9A 1E1ZP 1E33P 1KHNA 1Y6VA 2D1GA 1EJJA 3OT9A 1B8JA 3KD8A 4UORA 4LREA 1AJAA 3NKNA 1N2LA 1AJBA 2X98A 1ELYA 1ED9A 3UNYA 4CXUA 2IUCA 4LR7A 3WAXA 3ED4A 4FDIA 1E2SP 1KH5A 2W5XA 2XRGA 1O98A 4TN0A 4B56A 3LXQA 2ZKTA 1N2KA 3M8WA 3T01A 1ANIA 4UPKA 4GTXA 1ELZA
chains in the Genus database with same CATH superfamily
1ANJA 3M7VA 2XR9A 2W8SA 4CXKA 4LRAA 3WAVA 4KJDA 4LRCA 3TG0A 1AUKA 2W5VA 5LRNA 3UN5A 2W5TA 5AJ9A 3WBHA 2QZUA 1HJKA 5K4PA 4LRFA 3A52A 4NWJA 1ZEFA 2GSOA 3IGZB 3NKRA 4GTYA 4NWXA 3UN3A 1EW9A 2IUCB 4UOOA 3NKOA 1E3CP 5DLTA 1ZEBA 1SHQA 5HRTA 1KHLA 4KAVA 2GSNA 4UPIA 3B5QA 3TX0A 1URAA 4UPLA 4LRDA 1ALKA 2W5WA 5EGHA 3SZYA 3T02A 4KJGA 5L0BA 3CMRA 3BDHA 2ANHA 1AJDA 1EW8A 5KXAA 4LRBA 1ALIA 4ZG6A 1HQAA 1ALJA 4ZGAA 1URBA 2RH6A 5LIAA 1Y7AA 4MIVA 5IJSA 5LQQA 1KH7A 3NKMA 1KHKA 3E2DA 3IDDA 4MHXA 5IJQA 4KM4A 4CYRA 3BDGA 2W5RA 3NVLA 3UN2A 4ZG9A 2W8DA 3WAYA 5INHA 2VQRA 2GLQA 4N7TA 3SZZA 3NKQA 3NKPA 1O99A 4QAXA 3TWZA 2W5QA 3DPCA 3UO0A 3M8YA 5L0EA 4LQYA 1P49A 1EI6A 4CYSA 5C66A 3T00A 1EQJA 3DYCA 4FDJA 4UOPA 1KH9A 4MY4A 4GTZA 5TJ3A 4LR8A 2IFYA 1ED8A 3M8ZA 1KHJA 4KAYA 4LR2A 3Q3QA 5GRRA 5L0KA 1ELXA 3MK2A 3BDGB 1HDHA 1EW2A 5EGEA 5DLVA 4YR1A 1KH4A 3BDFA 2GA3A 3MK1A 4ZG7A 5LRMA 2W5SA 1FSUA 2G9YA 3IGYB 4UPHA 3WAWA 5GOVA 2GSUA 3MK0A 4GTWA 1K7HA 1AJCA 1ZEDA 1ALHA 1SHNA 5DLWA 4CXSA 4LR9A 1E1ZP 1E33P 1KHNA 1Y6VA 2D1GA 1EJJA 3OT9A 1B8JA 3KD8A 4UORA 4LREA 1AJAA 3NKNA 1N2LA 1AJBA 2X98A 1ELYA 1ED9A 3UNYA 4CXUA 2IUCA 4LR7A 3WAXA 3ED4A 4FDIA 1E2SP 1KH5A 2W5XA 2XRGA 1O98A 4TN0A 4B56A 3LXQA 2ZKTA 1N2KA 3M8WA 3T01A 1ANIA 4UPKA 4GTXA 1ELZA
chains in the Genus database with same CATH topology
1ANJA 3M7VA 2XR9A 2W8SA 4CXKA 4LRAA 3WAVA 4KJDA 4LRCA 3TG0A 1AUKA 2W5VA 5LRNA 3UN5A 2W5TA 5AJ9A 3WBHA 2QZUA 1HJKA 5K4PA 4LRFA 3A52A 4NWJA 1ZEFA 2GSOA 3IGZB 3NKRA 4GTYA 4NWXA 3UN3A 1EW9A 2IUCB 4UOOA 3NKOA 1E3CP 5DLTA 1ZEBA 1SHQA 5HRTA 1KHLA 4KAVA 2GSNA 4UPIA 3B5QA 3TX0A 1URAA 4UPLA 4LRDA 1ALKA 2W5WA 5EGHA 3SZYA 3T02A 4KJGA 5L0BA 3CMRA 3BDHA 2ANHA 1AJDA 1EW8A 5KXAA 4LRBA 1ALIA 4ZG6A 1HQAA 1ALJA 4ZGAA 1URBA 2RH6A 5LIAA 1Y7AA 4MIVA 5IJSA 5LQQA 1KH7A 3NKMA 1KHKA 3E2DA 3IDDA 4MHXA 5IJQA 4KM4A 4CYRA 3BDGA 2W5RA 3NVLA 3UN2A 4ZG9A 2W8DA 3WAYA 5INHA 2VQRA 2GLQA 4N7TA 3SZZA 3NKQA 3NKPA 1O99A 4QAXA 3TWZA 2W5QA 3DPCA 3UO0A 3M8YA 5L0EA 4LQYA 1P49A 1EI6A 4CYSA 5C66A 3T00A 1EQJA 3DYCA 4FDJA 4UOPA 1KH9A 4MY4A 4GTZA 5TJ3A 4LR8A 2IFYA 1ED8A 3M8ZA 1KHJA 4KAYA 4LR2A 3Q3QA 5GRRA 5L0KA 1ELXA 3MK2A 3BDGB 1HDHA 1EW2A 5EGEA 5DLVA 4YR1A 1KH4A 3BDFA 2GA3A 3MK1A 4ZG7A 5LRMA 2W5SA 1FSUA 2G9YA 3IGYB 4UPHA 3WAWA 5GOVA 2GSUA 3MK0A 4GTWA 1K7HA 1AJCA 1ZEDA 1ALHA 1SHNA 5DLWA 4CXSA 4LR9A 1E1ZP 1E33P 1KHNA 1Y6VA 2D1GA 1EJJA 3OT9A 1B8JA 3KD8A 4UORA 4LREA 1AJAA 3NKNA 1N2LA 1AJBA 2X98A 1ELYA 1ED9A 3UNYA 4CXUA 2IUCA 4LR7A 3WAXA 3ED4A 4FDIA 1E2SP 1KH5A 2W5XA 2XRGA 1O98A 4TN0A 4B56A 3LXQA 2ZKTA 1N2KA 3M8WA 3T01A 1ANIA 4UPKA 4GTXA 1ELZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ANJ A;  3M7V A;  2XR9 A;  2W8S A;  4CXK A;  4LRA A;  3WAV A;  4KJD A;  4LRC A;  3TG0 A;  1AUK A;  2W5V A;  5LRN A;  3UN5 A;  2W5T A;  5AJ9 A;  3WBH A;  2QZU A;  1HJK A;  5K4P A;  4LRF A;  3A52 A;  4NWJ A;  1ZEF A;  2GSO A;  3IGZ B;  3NKR A;  4GTY A;  4NWX A;  3UN3 A;  1EW9 A;  2IUC B;  4UOO A;  3NKO A;  1E3C P;  5DLT A;  1ZEB A;  1SHQ A;  5HRT A;  1KHL A;  4KAV A;  2GSN A;  4UPI A;  3B5Q A;  3TX0 A;  1URA A;  4UPL A;  4LRD A;  1ALK A;  2W5W A;  5EGH A;  3SZY A;  3T02 A;  4KJG A;  5L0B A;  3CMR A;  3BDH A;  2ANH A;  1AJD A;  1EW8 A;  5KXA A;  4LRB A;  1ALI A;  4ZG6 A;  1HQA A;  1ALJ A;  4ZGA A;  1URB A;  2RH6 A;  5LIA A;  1Y7A A;  4MIV A;  5IJS A;  5LQQ A;  1KH7 A;  3NKM A;  1KHK A;  3E2D A;  3IDD A;  4MHX A;  5IJQ A;  4KM4 A;  4CYR A;  3BDG A;  2W5R A;  3NVL A;  3UN2 A;  4ZG9 A;  2W8D A;  3WAY A;  5INH A;  2VQR A;  2GLQ A;  4N7T A;  3SZZ A;  3NKQ A;  3NKP A;  1O99 A;  4QAX A;  3TWZ A;  2W5Q A;  3DPC A;  3UO0 A;  3M8Y A;  5L0E A;  4LQY A;  1P49 A;  1EI6 A;  4CYS A;  5C66 A;  3T00 A;  1EQJ A;  3DYC A;  4FDJ A;  4UOP A;  1KH9 A;  4MY4 A;  4GTZ A;  5TJ3 A;  4LR8 A;  2IFY A;  1ED8 A;  3M8Z A;  1KHJ A;  4KAY A;  4LR2 A;  3Q3Q A;  5GRR A;  5L0K A;  1ELX A;  3MK2 A;  3BDG B;  1HDH A;  1EW2 A;  5EGE A;  5DLV A;  4YR1 A;  1KH4 A;  3BDF A;  2GA3 A;  3MK1 A;  4ZG7 A;  5LRM A;  2W5S A;  1FSU A;  2G9Y A;  3IGY B;  4UPH A;  3WAW A;  5GOV A;  2GSU A;  3MK0 A;  4GTW A;  1K7H A;  1AJC A;  1ZED A;  1ALH A;  1SHN A;  5DLW A;  4CXS A;  4LR9 A;  1E1Z P;  1E33 P;  1KHN A;  1Y6V A;  2D1G A;  1EJJ A;  3OT9 A;  1B8J A;  3KD8 A;  4UOR A;  4LRE A;  1AJA A;  3NKN A;  1N2L A;  1AJB A;  2X98 A;  1ELY A;  1ED9 A;  3UNY A;  4CXU A;  2IUC A;  4LR7 A;  3WAX A;  3ED4 A;  4FDI A;  1E2S P;  1KH5 A;  2W5X A;  2XRG A;  1O98 A;  4TN0 A;  4B56 A;  3LXQ A;  2ZKT A;  1N2K A;  3M8W A;  3T01 A;  1ANI A;  4UPK A;  4GTX A;  1ELZ A; 
#chains in the Genus database with same CATH topology
 1ANJ A;  3M7V A;  2XR9 A;  2W8S A;  4CXK A;  4LRA A;  3WAV A;  4KJD A;  4LRC A;  3TG0 A;  1AUK A;  2W5V A;  5LRN A;  3UN5 A;  2W5T A;  5AJ9 A;  3WBH A;  2QZU A;  1HJK A;  5K4P A;  4LRF A;  3A52 A;  4NWJ A;  1ZEF A;  2GSO A;  3IGZ B;  3NKR A;  4GTY A;  4NWX A;  3UN3 A;  1EW9 A;  2IUC B;  4UOO A;  3NKO A;  1E3C P;  5DLT A;  1ZEB A;  1SHQ A;  5HRT A;  1KHL A;  4KAV A;  2GSN A;  4UPI A;  3B5Q A;  3TX0 A;  1URA A;  4UPL A;  4LRD A;  1ALK A;  2W5W A;  5EGH A;  3SZY A;  3T02 A;  4KJG A;  5L0B A;  3CMR A;  3BDH A;  2ANH A;  1AJD A;  1EW8 A;  5KXA A;  4LRB A;  1ALI A;  4ZG6 A;  1HQA A;  1ALJ A;  4ZGA A;  1URB A;  2RH6 A;  5LIA A;  1Y7A A;  4MIV A;  5IJS A;  5LQQ A;  1KH7 A;  3NKM A;  1KHK A;  3E2D A;  3IDD A;  4MHX A;  5IJQ A;  4KM4 A;  4CYR A;  3BDG A;  2W5R A;  3NVL A;  3UN2 A;  4ZG9 A;  2W8D A;  3WAY A;  5INH A;  2VQR A;  2GLQ A;  4N7T A;  3SZZ A;  3NKQ A;  3NKP A;  1O99 A;  4QAX A;  3TWZ A;  2W5Q A;  3DPC A;  3UO0 A;  3M8Y A;  5L0E A;  4LQY A;  1P49 A;  1EI6 A;  4CYS A;  5C66 A;  3T00 A;  1EQJ A;  3DYC A;  4FDJ A;  4UOP A;  1KH9 A;  4MY4 A;  4GTZ A;  5TJ3 A;  4LR8 A;  2IFY A;  1ED8 A;  3M8Z A;  1KHJ A;  4KAY A;  4LR2 A;  3Q3Q A;  5GRR A;  5L0K A;  1ELX A;  3MK2 A;  3BDG B;  1HDH A;  1EW2 A;  5EGE A;  5DLV A;  4YR1 A;  1KH4 A;  3BDF A;  2GA3 A;  3MK1 A;  4ZG7 A;  5LRM A;  2W5S A;  1FSU A;  2G9Y A;  3IGY B;  4UPH A;  3WAW A;  5GOV A;  2GSU A;  3MK0 A;  4GTW A;  1K7H A;  1AJC A;  1ZED A;  1ALH A;  1SHN A;  5DLW A;  4CXS A;  4LR9 A;  1E1Z P;  1E33 P;  1KHN A;  1Y6V A;  2D1G A;  1EJJ A;  3OT9 A;  1B8J A;  3KD8 A;  4UOR A;  4LRE A;  1AJA A;  3NKN A;  1N2L A;  1AJB A;  2X98 A;  1ELY A;  1ED9 A;  3UNY A;  4CXU A;  2IUC A;  4LR7 A;  3WAX A;  3ED4 A;  4FDI A;  1E2S P;  1KH5 A;  2W5X A;  2XRG A;  1O98 A;  4TN0 A;  4B56 A;  3LXQ A;  2ZKT A;  1N2K A;  3M8W A;  3T01 A;  1ANI A;  4UPK A;  4GTX A;  1ELZ A; 
#chains in the Genus database with same CATH homology
 1ANJ A;  3M7V A;  2XR9 A;  2W8S A;  4CXK A;  4LRA A;  3WAV A;  4KJD A;  4LRC A;  3TG0 A;  1AUK A;  2W5V A;  5LRN A;  3UN5 A;  2W5T A;  5AJ9 A;  3WBH A;  2QZU A;  1HJK A;  5K4P A;  4LRF A;  3A52 A;  4NWJ A;  1ZEF A;  2GSO A;  3IGZ B;  3NKR A;  4GTY A;  4NWX A;  3UN3 A;  1EW9 A;  2IUC B;  4UOO A;  3NKO A;  1E3C P;  5DLT A;  1ZEB A;  1SHQ A;  5HRT A;  1KHL A;  4KAV A;  2GSN A;  4UPI A;  3B5Q A;  3TX0 A;  1URA A;  4UPL A;  4LRD A;  1ALK A;  2W5W A;  5EGH A;  3SZY A;  3T02 A;  4KJG A;  5L0B A;  3CMR A;  3BDH A;  2ANH A;  1AJD A;  1EW8 A;  5KXA A;  4LRB A;  1ALI A;  4ZG6 A;  1HQA A;  1ALJ A;  4ZGA A;  1URB A;  2RH6 A;  5LIA A;  1Y7A A;  4MIV A;  5IJS A;  5LQQ A;  1KH7 A;  3NKM A;  1KHK A;  3E2D A;  3IDD A;  4MHX A;  5IJQ A;  4KM4 A;  4CYR A;  3BDG A;  2W5R A;  3NVL A;  3UN2 A;  4ZG9 A;  2W8D A;  3WAY A;  5INH A;  2VQR A;  2GLQ A;  4N7T A;  3SZZ A;  3NKQ A;  3NKP A;  1O99 A;  4QAX A;  3TWZ A;  2W5Q A;  3DPC A;  3UO0 A;  3M8Y A;  5L0E A;  4LQY A;  1P49 A;  1EI6 A;  4CYS A;  5C66 A;  3T00 A;  1EQJ A;  3DYC A;  4FDJ A;  4UOP A;  1KH9 A;  4MY4 A;  4GTZ A;  5TJ3 A;  4LR8 A;  2IFY A;  1ED8 A;  3M8Z A;  1KHJ A;  4KAY A;  4LR2 A;  3Q3Q A;  5GRR A;  5L0K A;  1ELX A;  3MK2 A;  3BDG B;  1HDH A;  1EW2 A;  5EGE A;  5DLV A;  4YR1 A;  1KH4 A;  3BDF A;  2GA3 A;  3MK1 A;  4ZG7 A;  5LRM A;  2W5S A;  1FSU A;  2G9Y A;  3IGY B;  4UPH A;  3WAW A;  5GOV A;  2GSU A;  3MK0 A;  4GTW A;  1K7H A;  1AJC A;  1ZED A;  1ALH A;  1SHN A;  5DLW A;  4CXS A;  4LR9 A;  1E1Z P;  1E33 P;  1KHN A;  1Y6V A;  2D1G A;  1EJJ A;  3OT9 A;  1B8J A;  3KD8 A;  4UOR A;  4LRE A;  1AJA A;  3NKN A;  1N2L A;  1AJB A;  2X98 A;  1ELY A;  1ED9 A;  3UNY A;  4CXU A;  2IUC A;  4LR7 A;  3WAX A;  3ED4 A;  4FDI A;  1E2S P;  1KH5 A;  2W5X A;  2XRG A;  1O98 A;  4TN0 A;  4B56 A;  3LXQ A;  2ZKT A;  1N2K A;  3M8W A;  3T01 A;  1ANI A;  4UPK A;  4GTX A;  1ELZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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