1ALHA

Kinetics and crystal structure of a mutant e. coli alkaline phosphatase (asp-369-->asn): a mechanism involving one zinc per active site
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
446
structure length
446
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTANHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetics and crystal structure of a mutant Escherichia coli alkaline phosphatase (Asp-369-->Asn): a mechanism involving one zinc per active site.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 149
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1994-08-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alhA00
5LQQA 5IJSA 2W8SA 1ED8A 2GSOA 1ELYA 4B56A 1E33P 2GSUA 4KM4A 1K7HA 4UORA 4LREA 1Y6VA 3MK1A 1ANIA 1URAA 3IGZB 3MK0A 3UNYA 4TN0A 3BDGB 4MHXA 4LR8A 1B8JA 5GRRA 4NWXA 3E2DA 5DLTA 1ALJA 3WAWA 4YR1A 5LRNA 3M8WA 2XR9A 4UPHA 4ZGAA 5GOVA 3IDDA 3DYCA 3DPCA 1EI6A 1HJKA 1KH4A 2X98A 5L0EA 5L0BA 1ED9A 3KD8A 4GTZA 5KXAA 4LQYA 2W5QA 4KJGA 5LRMA 3LXQA 1AJBA 1SHQA 1EQJA 1ZEDA 3WAYA 3M8ZA 4CXUA 1AUKA 3MK2A 2IUCA 5EGEA 1P49A 3ED4A 4GTXA 4LR9A 4LR7A 4LRAA 1O99A 4GTWA 4LRFA 2GLQA 2RH6A 4KAVA 3UN2A 1N2KA 2W8DA 1KH9A 3T01A 3TX0A 3WBHA 4N7TA 4ZG9A 5LIAA 4NWJA 1E2SP 1O98A 3T02A 2W5XA 1ALKA 4CXSA 1ELXA 5C66A 4KAYA 5AJ9A 3NKRA 1KH5A 3M8YA 5DLWA 5DLVA 1URBA 1EW8A 4MY4A 2W5TA 3IGYB 3NKPA 1HDHA 3BDFA 1SHNA 1EJJA 5L0KA 5HRTA 2VQRA 2IFYA 4LR2A 4FDIA 1ZEFA 4CYSA 1HQAA 1AJDA 1Y7AA 2G9YA 5IJQA 3CMRA 4UOOA 5TJ3A 4FDJA 3BDGA 1ALIA 3OT9A 4LRDA 4CYRA 4MIVA 4CXKA 2W5WA 1EW2A 3NKQA 4UOPA 4UPKA 4UPIA 2QZUA 3NKNA 2GA3A 2ZKTA 3SZZA 2IUCB 3A52A 4KJDA 3BDHA 3UN3A 2GSNA 3NVLA 3NKOA 1ELZA 3UO0A 1ZEBA 4LRBA 5EGHA 1KHKA 4LRCA 1EW9A 2D1GA 5INHA 3TWZA 2W5VA 4ZG7A 1AJCA 4ZG6A 1E3CP 1FSUA 3UN5A 4UPLA 3B5QA 3M7VA 1KHLA 1KH7A 2XRGA 4QAXA 1N2LA 1KHJA 1AJAA 1E1ZP 4GTYA 3Q3QA 3WAXA 3SZYA 3T00A 2W5RA 2W5SA 1KHNA 3TG0A 1ALHA 1ANJA 3WAVA 5K4PA 2ANHA 3NKMA
chains in the Genus database with same CATH superfamily
5LQQA 5IJSA 2W8SA 1ED8A 2GSOA 1ELYA 4B56A 1E33P 2GSUA 4KM4A 1K7HA 4UORA 4LREA 1Y6VA 3MK1A 1ANIA 1URAA 3IGZB 3MK0A 3UNYA 4TN0A 3BDGB 4MHXA 4LR8A 1B8JA 5GRRA 4NWXA 3E2DA 5DLTA 1ALJA 3WAWA 4YR1A 5LRNA 3M8WA 2XR9A 4UPHA 4ZGAA 5GOVA 3IDDA 3DYCA 3DPCA 1EI6A 1HJKA 1KH4A 2X98A 5L0EA 5L0BA 1ED9A 3KD8A 4GTZA 5KXAA 4LQYA 2W5QA 4KJGA 5LRMA 3LXQA 1AJBA 1SHQA 1EQJA 1ZEDA 3WAYA 3M8ZA 4CXUA 1AUKA 3MK2A 2IUCA 5EGEA 1P49A 3ED4A 4GTXA 4LR9A 4LR7A 4LRAA 1O99A 4GTWA 4LRFA 2GLQA 2RH6A 4KAVA 3UN2A 1N2KA 2W8DA 1KH9A 3T01A 3TX0A 3WBHA 4N7TA 4ZG9A 5LIAA 4NWJA 1E2SP 1O98A 3T02A 2W5XA 1ALKA 4CXSA 1ELXA 5C66A 4KAYA 5AJ9A 3NKRA 1KH5A 3M8YA 5DLWA 5DLVA 1URBA 1EW8A 4MY4A 2W5TA 3IGYB 3NKPA 1HDHA 3BDFA 1SHNA 1EJJA 5L0KA 5HRTA 2VQRA 2IFYA 4LR2A 4FDIA 1ZEFA 4CYSA 1HQAA 1AJDA 1Y7AA 2G9YA 5IJQA 3CMRA 4UOOA 5TJ3A 4FDJA 3BDGA 1ALIA 3OT9A 4LRDA 4CYRA 4MIVA 4CXKA 2W5WA 1EW2A 3NKQA 4UOPA 4UPKA 4UPIA 2QZUA 3NKNA 2GA3A 2ZKTA 3SZZA 2IUCB 3A52A 4KJDA 3BDHA 3UN3A 2GSNA 3NVLA 3NKOA 1ELZA 3UO0A 1ZEBA 4LRBA 5EGHA 1KHKA 4LRCA 1EW9A 2D1GA 5INHA 3TWZA 2W5VA 4ZG7A 1AJCA 4ZG6A 1E3CP 1FSUA 3UN5A 4UPLA 3B5QA 3M7VA 1KHLA 1KH7A 2XRGA 4QAXA 1N2LA 1KHJA 1AJAA 1E1ZP 4GTYA 3Q3QA 3WAXA 3SZYA 3T00A 2W5RA 2W5SA 1KHNA 3TG0A 1ALHA 1ANJA 3WAVA 5K4PA 2ANHA 3NKMA
chains in the Genus database with same CATH topology
5LQQA 5IJSA 2W8SA 1ED8A 2GSOA 1ELYA 4B56A 1E33P 2GSUA 4KM4A 1K7HA 4UORA 4LREA 1Y6VA 3MK1A 1ANIA 1URAA 3IGZB 3MK0A 3UNYA 4TN0A 3BDGB 4MHXA 4LR8A 1B8JA 5GRRA 4NWXA 3E2DA 5DLTA 1ALJA 3WAWA 4YR1A 5LRNA 3M8WA 2XR9A 4UPHA 4ZGAA 5GOVA 3IDDA 3DYCA 3DPCA 1EI6A 1HJKA 1KH4A 2X98A 5L0EA 5L0BA 1ED9A 3KD8A 4GTZA 5KXAA 4LQYA 2W5QA 4KJGA 5LRMA 3LXQA 1AJBA 1SHQA 1EQJA 1ZEDA 3WAYA 3M8ZA 4CXUA 1AUKA 3MK2A 2IUCA 5EGEA 1P49A 3ED4A 4GTXA 4LR9A 4LR7A 4LRAA 1O99A 4GTWA 4LRFA 2GLQA 2RH6A 4KAVA 3UN2A 1N2KA 2W8DA 1KH9A 3T01A 3TX0A 3WBHA 4N7TA 4ZG9A 5LIAA 4NWJA 1E2SP 1O98A 3T02A 2W5XA 1ALKA 4CXSA 1ELXA 5C66A 4KAYA 5AJ9A 3NKRA 1KH5A 3M8YA 5DLWA 5DLVA 1URBA 1EW8A 4MY4A 2W5TA 3IGYB 3NKPA 1HDHA 3BDFA 1SHNA 1EJJA 5L0KA 5HRTA 2VQRA 2IFYA 4LR2A 4FDIA 1ZEFA 4CYSA 1HQAA 1AJDA 1Y7AA 2G9YA 5IJQA 3CMRA 4UOOA 5TJ3A 4FDJA 3BDGA 1ALIA 3OT9A 4LRDA 4CYRA 4MIVA 4CXKA 2W5WA 1EW2A 3NKQA 4UOPA 4UPKA 4UPIA 2QZUA 3NKNA 2GA3A 2ZKTA 3SZZA 2IUCB 3A52A 4KJDA 3BDHA 3UN3A 2GSNA 3NVLA 3NKOA 1ELZA 3UO0A 1ZEBA 4LRBA 5EGHA 1KHKA 4LRCA 1EW9A 2D1GA 5INHA 3TWZA 2W5VA 4ZG7A 1AJCA 4ZG6A 1E3CP 1FSUA 3UN5A 4UPLA 3B5QA 3M7VA 1KHLA 1KH7A 2XRGA 4QAXA 1N2LA 1KHJA 1AJAA 1E1ZP 4GTYA 3Q3QA 3WAXA 3SZYA 3T00A 2W5RA 2W5SA 1KHNA 3TG0A 1ALHA 1ANJA 3WAVA 5K4PA 2ANHA 3NKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LQQ A;  5IJS A;  2W8S A;  1ED8 A;  2GSO A;  1ELY A;  4B56 A;  1E33 P;  2GSU A;  4KM4 A;  1K7H A;  4UOR A;  4LRE A;  1Y6V A;  3MK1 A;  1ANI A;  1URA A;  3IGZ B;  3MK0 A;  3UNY A;  4TN0 A;  3BDG B;  4MHX A;  4LR8 A;  1B8J A;  5GRR A;  4NWX A;  3E2D A;  5DLT A;  1ALJ A;  3WAW A;  4YR1 A;  5LRN A;  3M8W A;  2XR9 A;  4UPH A;  4ZGA A;  5GOV A;  3IDD A;  3DYC A;  3DPC A;  1EI6 A;  1HJK A;  1KH4 A;  2X98 A;  5L0E A;  5L0B A;  1ED9 A;  3KD8 A;  4GTZ A;  5KXA A;  4LQY A;  2W5Q A;  4KJG A;  5LRM A;  3LXQ A;  1AJB A;  1SHQ A;  1EQJ A;  1ZED A;  3WAY A;  3M8Z A;  4CXU A;  1AUK A;  3MK2 A;  2IUC A;  5EGE A;  1P49 A;  3ED4 A;  4GTX A;  4LR9 A;  4LR7 A;  4LRA A;  1O99 A;  4GTW A;  4LRF A;  2GLQ A;  2RH6 A;  4KAV A;  3UN2 A;  1N2K A;  2W8D A;  1KH9 A;  3T01 A;  3TX0 A;  3WBH A;  4N7T A;  4ZG9 A;  5LIA A;  4NWJ A;  1E2S P;  1O98 A;  3T02 A;  2W5X A;  1ALK A;  4CXS A;  1ELX A;  5C66 A;  4KAY A;  5AJ9 A;  3NKR A;  1KH5 A;  3M8Y A;  5DLW A;  5DLV A;  1URB A;  1EW8 A;  4MY4 A;  2W5T A;  3IGY B;  3NKP A;  1HDH A;  3BDF A;  1SHN A;  1EJJ A;  5L0K A;  5HRT A;  2VQR A;  2IFY A;  4LR2 A;  4FDI A;  1ZEF A;  4CYS A;  1HQA A;  1AJD A;  1Y7A A;  2G9Y A;  5IJQ A;  3CMR A;  4UOO A;  5TJ3 A;  4FDJ A;  3BDG A;  1ALI A;  3OT9 A;  4LRD A;  4CYR A;  4MIV A;  4CXK A;  2W5W A;  1EW2 A;  3NKQ A;  4UOP A;  4UPK A;  4UPI A;  2QZU A;  3NKN A;  2GA3 A;  2ZKT A;  3SZZ A;  2IUC B;  3A52 A;  4KJD A;  3BDH A;  3UN3 A;  2GSN A;  3NVL A;  3NKO A;  1ELZ A;  3UO0 A;  1ZEB A;  4LRB A;  5EGH A;  1KHK A;  4LRC A;  1EW9 A;  2D1G A;  5INH A;  3TWZ A;  2W5V A;  4ZG7 A;  1AJC A;  4ZG6 A;  1E3C P;  1FSU A;  3UN5 A;  4UPL A;  3B5Q A;  3M7V A;  1KHL A;  1KH7 A;  2XRG A;  4QAX A;  1N2L A;  1KHJ A;  1AJA A;  1E1Z P;  4GTY A;  3Q3Q A;  3WAX A;  3SZY A;  3T00 A;  2W5R A;  2W5S A;  1KHN A;  3TG0 A;  1ALH A;  1ANJ A;  3WAV A;  5K4P A;  2ANH A;  3NKM A; 
#chains in the Genus database with same CATH topology
 5LQQ A;  5IJS A;  2W8S A;  1ED8 A;  2GSO A;  1ELY A;  4B56 A;  1E33 P;  2GSU A;  4KM4 A;  1K7H A;  4UOR A;  4LRE A;  1Y6V A;  3MK1 A;  1ANI A;  1URA A;  3IGZ B;  3MK0 A;  3UNY A;  4TN0 A;  3BDG B;  4MHX A;  4LR8 A;  1B8J A;  5GRR A;  4NWX A;  3E2D A;  5DLT A;  1ALJ A;  3WAW A;  4YR1 A;  5LRN A;  3M8W A;  2XR9 A;  4UPH A;  4ZGA A;  5GOV A;  3IDD A;  3DYC A;  3DPC A;  1EI6 A;  1HJK A;  1KH4 A;  2X98 A;  5L0E A;  5L0B A;  1ED9 A;  3KD8 A;  4GTZ A;  5KXA A;  4LQY A;  2W5Q A;  4KJG A;  5LRM A;  3LXQ A;  1AJB A;  1SHQ A;  1EQJ A;  1ZED A;  3WAY A;  3M8Z A;  4CXU A;  1AUK A;  3MK2 A;  2IUC A;  5EGE A;  1P49 A;  3ED4 A;  4GTX A;  4LR9 A;  4LR7 A;  4LRA A;  1O99 A;  4GTW A;  4LRF A;  2GLQ A;  2RH6 A;  4KAV A;  3UN2 A;  1N2K A;  2W8D A;  1KH9 A;  3T01 A;  3TX0 A;  3WBH A;  4N7T A;  4ZG9 A;  5LIA A;  4NWJ A;  1E2S P;  1O98 A;  3T02 A;  2W5X A;  1ALK A;  4CXS A;  1ELX A;  5C66 A;  4KAY A;  5AJ9 A;  3NKR A;  1KH5 A;  3M8Y A;  5DLW A;  5DLV A;  1URB A;  1EW8 A;  4MY4 A;  2W5T A;  3IGY B;  3NKP A;  1HDH A;  3BDF A;  1SHN A;  1EJJ A;  5L0K A;  5HRT A;  2VQR A;  2IFY A;  4LR2 A;  4FDI A;  1ZEF A;  4CYS A;  1HQA A;  1AJD A;  1Y7A A;  2G9Y A;  5IJQ A;  3CMR A;  4UOO A;  5TJ3 A;  4FDJ A;  3BDG A;  1ALI A;  3OT9 A;  4LRD A;  4CYR A;  4MIV A;  4CXK A;  2W5W A;  1EW2 A;  3NKQ A;  4UOP A;  4UPK A;  4UPI A;  2QZU A;  3NKN A;  2GA3 A;  2ZKT A;  3SZZ A;  2IUC B;  3A52 A;  4KJD A;  3BDH A;  3UN3 A;  2GSN A;  3NVL A;  3NKO A;  1ELZ A;  3UO0 A;  1ZEB A;  4LRB A;  5EGH A;  1KHK A;  4LRC A;  1EW9 A;  2D1G A;  5INH A;  3TWZ A;  2W5V A;  4ZG7 A;  1AJC A;  4ZG6 A;  1E3C P;  1FSU A;  3UN5 A;  4UPL A;  3B5Q A;  3M7V A;  1KHL A;  1KH7 A;  2XRG A;  4QAX A;  1N2L A;  1KHJ A;  1AJA A;  1E1Z P;  4GTY A;  3Q3Q A;  3WAX A;  3SZY A;  3T00 A;  2W5R A;  2W5S A;  1KHN A;  3TG0 A;  1ALH A;  1ANJ A;  3WAV A;  5K4P A;  2ANH A;  3NKM A; 
#chains in the Genus database with same CATH homology
 5LQQ A;  5IJS A;  2W8S A;  1ED8 A;  2GSO A;  1ELY A;  4B56 A;  1E33 P;  2GSU A;  4KM4 A;  1K7H A;  4UOR A;  4LRE A;  1Y6V A;  3MK1 A;  1ANI A;  1URA A;  3IGZ B;  3MK0 A;  3UNY A;  4TN0 A;  3BDG B;  4MHX A;  4LR8 A;  1B8J A;  5GRR A;  4NWX A;  3E2D A;  5DLT A;  1ALJ A;  3WAW A;  4YR1 A;  5LRN A;  3M8W A;  2XR9 A;  4UPH A;  4ZGA A;  5GOV A;  3IDD A;  3DYC A;  3DPC A;  1EI6 A;  1HJK A;  1KH4 A;  2X98 A;  5L0E A;  5L0B A;  1ED9 A;  3KD8 A;  4GTZ A;  5KXA A;  4LQY A;  2W5Q A;  4KJG A;  5LRM A;  3LXQ A;  1AJB A;  1SHQ A;  1EQJ A;  1ZED A;  3WAY A;  3M8Z A;  4CXU A;  1AUK A;  3MK2 A;  2IUC A;  5EGE A;  1P49 A;  3ED4 A;  4GTX A;  4LR9 A;  4LR7 A;  4LRA A;  1O99 A;  4GTW A;  4LRF A;  2GLQ A;  2RH6 A;  4KAV A;  3UN2 A;  1N2K A;  2W8D A;  1KH9 A;  3T01 A;  3TX0 A;  3WBH A;  4N7T A;  4ZG9 A;  5LIA A;  4NWJ A;  1E2S P;  1O98 A;  3T02 A;  2W5X A;  1ALK A;  4CXS A;  1ELX A;  5C66 A;  4KAY A;  5AJ9 A;  3NKR A;  1KH5 A;  3M8Y A;  5DLW A;  5DLV A;  1URB A;  1EW8 A;  4MY4 A;  2W5T A;  3IGY B;  3NKP A;  1HDH A;  3BDF A;  1SHN A;  1EJJ A;  5L0K A;  5HRT A;  2VQR A;  2IFY A;  4LR2 A;  4FDI A;  1ZEF A;  4CYS A;  1HQA A;  1AJD A;  1Y7A A;  2G9Y A;  5IJQ A;  3CMR A;  4UOO A;  5TJ3 A;  4FDJ A;  3BDG A;  1ALI A;  3OT9 A;  4LRD A;  4CYR A;  4MIV A;  4CXK A;  2W5W A;  1EW2 A;  3NKQ A;  4UOP A;  4UPK A;  4UPI A;  2QZU A;  3NKN A;  2GA3 A;  2ZKT A;  3SZZ A;  2IUC B;  3A52 A;  4KJD A;  3BDH A;  3UN3 A;  2GSN A;  3NVL A;  3NKO A;  1ELZ A;  3UO0 A;  1ZEB A;  4LRB A;  5EGH A;  1KHK A;  4LRC A;  1EW9 A;  2D1G A;  5INH A;  3TWZ A;  2W5V A;  4ZG7 A;  1AJC A;  4ZG6 A;  1E3C P;  1FSU A;  3UN5 A;  4UPL A;  3B5Q A;  3M7V A;  1KHL A;  1KH7 A;  2XRG A;  4QAX A;  1N2L A;  1KHJ A;  1AJA A;  1E1Z P;  4GTY A;  3Q3Q A;  3WAX A;  3SZY A;  3T00 A;  2W5R A;  2W5S A;  1KHN A;  3TG0 A;  1ALH A;  1ANJ A;  3WAV A;  5K4P A;  2ANH A;  3NKM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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