1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
4MIVA 5INHA 3MK1A 5IJSA 4LREA 1KHJA 3IGYB 4NWXA 2W5QA 1E1ZP 1ZEFA 2W5XA 3ED4A 3LXQA 4UPKA 3DYCA 4CYSA 4GTZA 5LIAA 1E2SP 3UN2A 4LR7A 5IJQA 2W5SA 3A52A 2VQRA 4LRFA 1ALJA 1P49A 2ZKTA 4LQYA 4UPHA 4N7TA 1EI6A 4KAVA 5EGHA 3NKOA 5LRNA 2W8SA 4UPLA 3NKQA 1SHNA 1EW8A 1KHLA 1O98A 4TN0A 1K7HA 1KHNA 1ELZA 4CYRA 3IGZB 4YR1A 5GRRA 1URBA 5AJ9A 1KH9A 2GSOA 1ELXA 3Q3QA 2IUCA 4CXSA 2D1GA 5DLWA 3T02A 3M8ZA 4LR2A 3M8WA 1AUKA 1O99A 1EJJA 2W8DA 3SZYA 4FDIA 1FSUA 1HJKA 1AJAA 4NWJA 3NKPA 3NKMA 1EW9A 2GSNA 4UOPA 3E2DA 1B8JA 4LRAA 5K4PA 1EW2A 4UOOA 1KHKA 5KXAA 5L0KA 4MHXA 4ZG6A 3IDDA 4ZGAA 1N2LA 4LRCA 4UORA 3M8YA 1SHQA 2IFYA 2W5VA 1EQJA 2IUCB 1ALHA 4GTYA 4ZG7A 5DLVA 3KD8A 3WAXA 5LRMA 3BDGA 3WAWA 5LQQA 5L0BA 1E33P 1Y6VA 1ALIA 3DPCA 4LR8A 4LRBA 3WBHA 1ED8A 1HQAA 1N2KA 3OT9A 1KH7A 3NVLA 3CMRA 2XR9A 1AJBA 4CXUA 5DLTA 1KH4A 5GOVA 4MY4A 3M7VA 1AJCA 4B56A 4FDJA 1AJDA 4LR9A 2W5TA 3WAYA 2GLQA 4GTXA 5C66A 3WAVA 3BDGB 3SZZA 5TJ3A 4CXKA 2RH6A 2GA3A 1ED9A 2G9YA 4QAXA 1ANJA 3TX0A 3MK0A 1HDHA 3B5QA 3BDHA 4KAYA 2XRGA 2QZUA 1ANIA 1URAA 5HRTA 1KH5A 1ZEDA 2X98A 1ELYA 3UO0A 4KM4A 3UN5A 2W5RA 4LRDA 3T00A 1ALKA 3TG0A 2ANHA 4UPIA 4GTWA 1Y7AA 4KJGA 4KJDA 3MK2A 3UN3A 2GSUA 3BDFA 3TWZA 2W5WA 3NKNA 5EGEA 3NKRA 3T01A 1ZEBA 5L0EA 1E3CP 4ZG9A 3UNYA
chains in the Genus database with same CATH superfamily
4MIVA 5INHA 3MK1A 5IJSA 4LREA 1KHJA 3IGYB 4NWXA 2W5QA 1E1ZP 1ZEFA 2W5XA 3ED4A 3LXQA 4UPKA 3DYCA 4CYSA 4GTZA 5LIAA 1E2SP 3UN2A 4LR7A 5IJQA 2W5SA 3A52A 2VQRA 4LRFA 1ALJA 1P49A 2ZKTA 4LQYA 4UPHA 4N7TA 1EI6A 4KAVA 5EGHA 3NKOA 5LRNA 2W8SA 4UPLA 3NKQA 1SHNA 1EW8A 1KHLA 1O98A 4TN0A 1K7HA 1KHNA 1ELZA 4CYRA 3IGZB 4YR1A 5GRRA 1URBA 5AJ9A 1KH9A 2GSOA 1ELXA 3Q3QA 2IUCA 4CXSA 2D1GA 5DLWA 3T02A 3M8ZA 4LR2A 3M8WA 1AUKA 1O99A 1EJJA 2W8DA 3SZYA 4FDIA 1FSUA 1HJKA 1AJAA 4NWJA 3NKPA 3NKMA 1EW9A 2GSNA 4UOPA 3E2DA 1B8JA 4LRAA 5K4PA 1EW2A 4UOOA 1KHKA 5KXAA 5L0KA 4MHXA 4ZG6A 3IDDA 4ZGAA 1N2LA 4LRCA 4UORA 3M8YA 1SHQA 2IFYA 2W5VA 1EQJA 2IUCB 1ALHA 4GTYA 4ZG7A 5DLVA 3KD8A 3WAXA 5LRMA 3BDGA 3WAWA 5LQQA 5L0BA 1E33P 1Y6VA 1ALIA 3DPCA 4LR8A 4LRBA 3WBHA 1ED8A 1HQAA 1N2KA 3OT9A 1KH7A 3NVLA 3CMRA 2XR9A 1AJBA 4CXUA 5DLTA 1KH4A 5GOVA 4MY4A 3M7VA 1AJCA 4B56A 4FDJA 1AJDA 4LR9A 2W5TA 3WAYA 2GLQA 4GTXA 5C66A 3WAVA 3BDGB 3SZZA 5TJ3A 4CXKA 2RH6A 2GA3A 1ED9A 2G9YA 4QAXA 1ANJA 3TX0A 3MK0A 1HDHA 3B5QA 3BDHA 4KAYA 2XRGA 2QZUA 1ANIA 1URAA 5HRTA 1KH5A 1ZEDA 2X98A 1ELYA 3UO0A 4KM4A 3UN5A 2W5RA 4LRDA 3T00A 1ALKA 3TG0A 2ANHA 4UPIA 4GTWA 1Y7AA 4KJGA 4KJDA 3MK2A 3UN3A 2GSUA 3BDFA 3TWZA 2W5WA 3NKNA 5EGEA 3NKRA 3T01A 1ZEBA 5L0EA 1E3CP 4ZG9A 3UNYA
chains in the Genus database with same CATH topology
4MIVA 5INHA 3MK1A 5IJSA 4LREA 1KHJA 3IGYB 4NWXA 2W5QA 1E1ZP 1ZEFA 2W5XA 3ED4A 3LXQA 4UPKA 3DYCA 4CYSA 4GTZA 5LIAA 1E2SP 3UN2A 4LR7A 5IJQA 2W5SA 3A52A 2VQRA 4LRFA 1ALJA 1P49A 2ZKTA 4LQYA 4UPHA 4N7TA 1EI6A 4KAVA 5EGHA 3NKOA 5LRNA 2W8SA 4UPLA 3NKQA 1SHNA 1EW8A 1KHLA 1O98A 4TN0A 1K7HA 1KHNA 1ELZA 4CYRA 3IGZB 4YR1A 5GRRA 1URBA 5AJ9A 1KH9A 2GSOA 1ELXA 3Q3QA 2IUCA 4CXSA 2D1GA 5DLWA 3T02A 3M8ZA 4LR2A 3M8WA 1AUKA 1O99A 1EJJA 2W8DA 3SZYA 4FDIA 1FSUA 1HJKA 1AJAA 4NWJA 3NKPA 3NKMA 1EW9A 2GSNA 4UOPA 3E2DA 1B8JA 4LRAA 5K4PA 1EW2A 4UOOA 1KHKA 5KXAA 5L0KA 4MHXA 4ZG6A 3IDDA 4ZGAA 1N2LA 4LRCA 4UORA 3M8YA 1SHQA 2IFYA 2W5VA 1EQJA 2IUCB 1ALHA 4GTYA 4ZG7A 5DLVA 3KD8A 3WAXA 5LRMA 3BDGA 3WAWA 5LQQA 5L0BA 1E33P 1Y6VA 1ALIA 3DPCA 4LR8A 4LRBA 3WBHA 1ED8A 1HQAA 1N2KA 3OT9A 1KH7A 3NVLA 3CMRA 2XR9A 1AJBA 4CXUA 5DLTA 1KH4A 5GOVA 4MY4A 3M7VA 1AJCA 4B56A 4FDJA 1AJDA 4LR9A 2W5TA 3WAYA 2GLQA 4GTXA 5C66A 3WAVA 3BDGB 3SZZA 5TJ3A 4CXKA 2RH6A 2GA3A 1ED9A 2G9YA 4QAXA 1ANJA 3TX0A 3MK0A 1HDHA 3B5QA 3BDHA 4KAYA 2XRGA 2QZUA 1ANIA 1URAA 5HRTA 1KH5A 1ZEDA 2X98A 1ELYA 3UO0A 4KM4A 3UN5A 2W5RA 4LRDA 3T00A 1ALKA 3TG0A 2ANHA 4UPIA 4GTWA 1Y7AA 4KJGA 4KJDA 3MK2A 3UN3A 2GSUA 3BDFA 3TWZA 2W5WA 3NKNA 5EGEA 3NKRA 3T01A 1ZEBA 5L0EA 1E3CP 4ZG9A 3UNYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4MIV A;  5INH A;  3MK1 A;  5IJS A;  4LRE A;  1KHJ A;  3IGY B;  4NWX A;  2W5Q A;  1E1Z P;  1ZEF A;  2W5X A;  3ED4 A;  3LXQ A;  4UPK A;  3DYC A;  4CYS A;  4GTZ A;  5LIA A;  1E2S P;  3UN2 A;  4LR7 A;  5IJQ A;  2W5S A;  3A52 A;  2VQR A;  4LRF A;  1ALJ A;  1P49 A;  2ZKT A;  4LQY A;  4UPH A;  4N7T A;  1EI6 A;  4KAV A;  5EGH A;  3NKO A;  5LRN A;  2W8S A;  4UPL A;  3NKQ A;  1SHN A;  1EW8 A;  1KHL A;  1O98 A;  4TN0 A;  1K7H A;  1KHN A;  1ELZ A;  4CYR A;  3IGZ B;  4YR1 A;  5GRR A;  1URB A;  5AJ9 A;  1KH9 A;  2GSO A;  1ELX A;  3Q3Q A;  2IUC A;  4CXS A;  2D1G A;  5DLW A;  3T02 A;  3M8Z A;  4LR2 A;  3M8W A;  1AUK A;  1O99 A;  1EJJ A;  2W8D A;  3SZY A;  4FDI A;  1FSU A;  1HJK A;  1AJA A;  4NWJ A;  3NKP A;  3NKM A;  1EW9 A;  2GSN A;  4UOP A;  3E2D A;  1B8J A;  4LRA A;  5K4P A;  1EW2 A;  4UOO A;  1KHK A;  5KXA A;  5L0K A;  4MHX A;  4ZG6 A;  3IDD A;  4ZGA A;  1N2L A;  4LRC A;  4UOR A;  3M8Y A;  1SHQ A;  2IFY A;  2W5V A;  1EQJ A;  2IUC B;  1ALH A;  4GTY A;  4ZG7 A;  5DLV A;  3KD8 A;  3WAX A;  5LRM A;  3BDG A;  3WAW A;  5LQQ A;  5L0B A;  1E33 P;  1Y6V A;  1ALI A;  3DPC A;  4LR8 A;  4LRB A;  3WBH A;  1ED8 A;  1HQA A;  1N2K A;  3OT9 A;  1KH7 A;  3NVL A;  3CMR A;  2XR9 A;  1AJB A;  4CXU A;  5DLT A;  1KH4 A;  5GOV A;  4MY4 A;  3M7V A;  1AJC A;  4B56 A;  4FDJ A;  1AJD A;  4LR9 A;  2W5T A;  3WAY A;  2GLQ A;  4GTX A;  5C66 A;  3WAV A;  3BDG B;  3SZZ A;  5TJ3 A;  4CXK A;  2RH6 A;  2GA3 A;  1ED9 A;  2G9Y A;  4QAX A;  1ANJ A;  3TX0 A;  3MK0 A;  1HDH A;  3B5Q A;  3BDH A;  4KAY A;  2XRG A;  2QZU A;  1ANI A;  1URA A;  5HRT A;  1KH5 A;  1ZED A;  2X98 A;  1ELY A;  3UO0 A;  4KM4 A;  3UN5 A;  2W5R A;  4LRD A;  3T00 A;  1ALK A;  3TG0 A;  2ANH A;  4UPI A;  4GTW A;  1Y7A A;  4KJG A;  4KJD A;  3MK2 A;  3UN3 A;  2GSU A;  3BDF A;  3TWZ A;  2W5W A;  3NKN A;  5EGE A;  3NKR A;  3T01 A;  1ZEB A;  5L0E A;  1E3C P;  4ZG9 A;  3UNY A; 
#chains in the Genus database with same CATH topology
 4MIV A;  5INH A;  3MK1 A;  5IJS A;  4LRE A;  1KHJ A;  3IGY B;  4NWX A;  2W5Q A;  1E1Z P;  1ZEF A;  2W5X A;  3ED4 A;  3LXQ A;  4UPK A;  3DYC A;  4CYS A;  4GTZ A;  5LIA A;  1E2S P;  3UN2 A;  4LR7 A;  5IJQ A;  2W5S A;  3A52 A;  2VQR A;  4LRF A;  1ALJ A;  1P49 A;  2ZKT A;  4LQY A;  4UPH A;  4N7T A;  1EI6 A;  4KAV A;  5EGH A;  3NKO A;  5LRN A;  2W8S A;  4UPL A;  3NKQ A;  1SHN A;  1EW8 A;  1KHL A;  1O98 A;  4TN0 A;  1K7H A;  1KHN A;  1ELZ A;  4CYR A;  3IGZ B;  4YR1 A;  5GRR A;  1URB A;  5AJ9 A;  1KH9 A;  2GSO A;  1ELX A;  3Q3Q A;  2IUC A;  4CXS A;  2D1G A;  5DLW A;  3T02 A;  3M8Z A;  4LR2 A;  3M8W A;  1AUK A;  1O99 A;  1EJJ A;  2W8D A;  3SZY A;  4FDI A;  1FSU A;  1HJK A;  1AJA A;  4NWJ A;  3NKP A;  3NKM A;  1EW9 A;  2GSN A;  4UOP A;  3E2D A;  1B8J A;  4LRA A;  5K4P A;  1EW2 A;  4UOO A;  1KHK A;  5KXA A;  5L0K A;  4MHX A;  4ZG6 A;  3IDD A;  4ZGA A;  1N2L A;  4LRC A;  4UOR A;  3M8Y A;  1SHQ A;  2IFY A;  2W5V A;  1EQJ A;  2IUC B;  1ALH A;  4GTY A;  4ZG7 A;  5DLV A;  3KD8 A;  3WAX A;  5LRM A;  3BDG A;  3WAW A;  5LQQ A;  5L0B A;  1E33 P;  1Y6V A;  1ALI A;  3DPC A;  4LR8 A;  4LRB A;  3WBH A;  1ED8 A;  1HQA A;  1N2K A;  3OT9 A;  1KH7 A;  3NVL A;  3CMR A;  2XR9 A;  1AJB A;  4CXU A;  5DLT A;  1KH4 A;  5GOV A;  4MY4 A;  3M7V A;  1AJC A;  4B56 A;  4FDJ A;  1AJD A;  4LR9 A;  2W5T A;  3WAY A;  2GLQ A;  4GTX A;  5C66 A;  3WAV A;  3BDG B;  3SZZ A;  5TJ3 A;  4CXK A;  2RH6 A;  2GA3 A;  1ED9 A;  2G9Y A;  4QAX A;  1ANJ A;  3TX0 A;  3MK0 A;  1HDH A;  3B5Q A;  3BDH A;  4KAY A;  2XRG A;  2QZU A;  1ANI A;  1URA A;  5HRT A;  1KH5 A;  1ZED A;  2X98 A;  1ELY A;  3UO0 A;  4KM4 A;  3UN5 A;  2W5R A;  4LRD A;  3T00 A;  1ALK A;  3TG0 A;  2ANH A;  4UPI A;  4GTW A;  1Y7A A;  4KJG A;  4KJD A;  3MK2 A;  3UN3 A;  2GSU A;  3BDF A;  3TWZ A;  2W5W A;  3NKN A;  5EGE A;  3NKR A;  3T01 A;  1ZEB A;  5L0E A;  1E3C P;  4ZG9 A;  3UNY A; 
#chains in the Genus database with same CATH homology
 4MIV A;  5INH A;  3MK1 A;  5IJS A;  4LRE A;  1KHJ A;  3IGY B;  4NWX A;  2W5Q A;  1E1Z P;  1ZEF A;  2W5X A;  3ED4 A;  3LXQ A;  4UPK A;  3DYC A;  4CYS A;  4GTZ A;  5LIA A;  1E2S P;  3UN2 A;  4LR7 A;  5IJQ A;  2W5S A;  3A52 A;  2VQR A;  4LRF A;  1ALJ A;  1P49 A;  2ZKT A;  4LQY A;  4UPH A;  4N7T A;  1EI6 A;  4KAV A;  5EGH A;  3NKO A;  5LRN A;  2W8S A;  4UPL A;  3NKQ A;  1SHN A;  1EW8 A;  1KHL A;  1O98 A;  4TN0 A;  1K7H A;  1KHN A;  1ELZ A;  4CYR A;  3IGZ B;  4YR1 A;  5GRR A;  1URB A;  5AJ9 A;  1KH9 A;  2GSO A;  1ELX A;  3Q3Q A;  2IUC A;  4CXS A;  2D1G A;  5DLW A;  3T02 A;  3M8Z A;  4LR2 A;  3M8W A;  1AUK A;  1O99 A;  1EJJ A;  2W8D A;  3SZY A;  4FDI A;  1FSU A;  1HJK A;  1AJA A;  4NWJ A;  3NKP A;  3NKM A;  1EW9 A;  2GSN A;  4UOP A;  3E2D A;  1B8J A;  4LRA A;  5K4P A;  1EW2 A;  4UOO A;  1KHK A;  5KXA A;  5L0K A;  4MHX A;  4ZG6 A;  3IDD A;  4ZGA A;  1N2L A;  4LRC A;  4UOR A;  3M8Y A;  1SHQ A;  2IFY A;  2W5V A;  1EQJ A;  2IUC B;  1ALH A;  4GTY A;  4ZG7 A;  5DLV A;  3KD8 A;  3WAX A;  5LRM A;  3BDG A;  3WAW A;  5LQQ A;  5L0B A;  1E33 P;  1Y6V A;  1ALI A;  3DPC A;  4LR8 A;  4LRB A;  3WBH A;  1ED8 A;  1HQA A;  1N2K A;  3OT9 A;  1KH7 A;  3NVL A;  3CMR A;  2XR9 A;  1AJB A;  4CXU A;  5DLT A;  1KH4 A;  5GOV A;  4MY4 A;  3M7V A;  1AJC A;  4B56 A;  4FDJ A;  1AJD A;  4LR9 A;  2W5T A;  3WAY A;  2GLQ A;  4GTX A;  5C66 A;  3WAV A;  3BDG B;  3SZZ A;  5TJ3 A;  4CXK A;  2RH6 A;  2GA3 A;  1ED9 A;  2G9Y A;  4QAX A;  1ANJ A;  3TX0 A;  3MK0 A;  1HDH A;  3B5Q A;  3BDH A;  4KAY A;  2XRG A;  2QZU A;  1ANI A;  1URA A;  5HRT A;  1KH5 A;  1ZED A;  2X98 A;  1ELY A;  3UO0 A;  4KM4 A;  3UN5 A;  2W5R A;  4LRD A;  3T00 A;  1ALK A;  3TG0 A;  2ANH A;  4UPI A;  4GTW A;  1Y7A A;  4KJG A;  4KJD A;  3MK2 A;  3UN3 A;  2GSU A;  3BDF A;  3TWZ A;  2W5W A;  3NKN A;  5EGE A;  3NKR A;  3T01 A;  1ZEB A;  5L0E A;  1E3C P;  4ZG9 A;  3UNY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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