1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords PHOSPHATASE
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
4KM4A 4GTYA 3Q3QA 4MIVA 5LIAA 4KJGA 5K4PA 1FSUA 1ED9A 1O98A 3NKMA 4TN0A 1K7HA 4YR1A 5DLWA 4KAYA 3WAVA 2GSUA 3OT9A 1N2KA 5IJQA 5C66A 1KHJA 4LRAA 1EW2A 4MY4A 3UO0A 4UPHA 3B5QA 3SZZA 1N2LA 1Y7AA 5GOVA 5LRNA 1E33P 5INHA 1AJAA 1ALJA 1KHKA 2W5XA 1ELYA 4ZG7A 1HQAA 1ALHA 1P49A 1KH9A 3NKRA 3CMRA 3KD8A 1KHNA 1AJBA 1E2SP 4NWXA 2W5RA 1KH4A 3DPCA 3WBHA 3IDDA 4CXKA 3UN3A 4KJDA 1ELXA 5IJSA 1ED8A 2W8DA 3UNYA 1E1ZP 4B56A 3M8YA 4CXSA 1KHLA 4LR7A 4UPKA 5AJ9A 4UPLA 2XR9A 1ELZA 3UN5A 3MK1A 1SHQA 4FDJA 1E3CP 4LRBA 1EW8A 1ZEBA 2VQRA 2IFYA 5DLTA 4GTZA 3WAYA 4N7TA 2W5QA 3T02A 2ANHA 1ANIA 2QZUA 4GTXA 2IUCB 3WAWA 2GLQA 4ZG9A 5EGEA 5TJ3A 2W5WA 4UOPA 3SZYA 5LRMA 1ANJA 2XRGA 1EQJA 1AUKA 4UORA 4FDIA 3MK0A 2D1GA 2GSOA 1AJCA 4MHXA 3ED4A 3BDGB 2IUCA 3NKPA 4KAVA 3WAXA 1EJJA 2W5TA 3TX0A 1Y6VA 2ZKTA 5EGHA 4LR9A 1ALIA 3MK2A 1KH5A 4CYSA 5DLVA 3NVLA 4LRFA 5L0BA 2X98A 4LR2A 2GA3A 3TG0A 3NKNA 3T01A 3TWZA 4ZG6A 2W5SA 1EI6A 3NKQA 1O99A 2G9YA 3BDGA 5L0KA 3IGZB 4QAXA 3NKOA 5HRTA 3E2DA 1AJDA 3LXQA 5L0EA 3UN2A 4LQYA 4CYRA 3IGYB 2GSNA 3DYCA 5KXAA 4LRCA 5GRRA 1KH7A 5LQQA 3A52A 4CXUA 1URBA 1ALKA 3M7VA 2W8SA 3BDFA 4NWJA 1URAA 4GTWA 4UPIA 4LR8A 1SHNA 3T00A 1ZEFA 1HJKA 2W5VA 3M8WA 3M8ZA 4LREA 4ZGAA 3BDHA 1ZEDA 1B8JA 4UOOA 1HDHA 4LRDA 1EW9A 2RH6A
chains in the Genus database with same CATH superfamily
4KM4A 4GTYA 3Q3QA 4MIVA 5LIAA 4KJGA 5K4PA 1FSUA 1ED9A 1O98A 3NKMA 4TN0A 1K7HA 4YR1A 5DLWA 4KAYA 3WAVA 2GSUA 3OT9A 1N2KA 5IJQA 5C66A 1KHJA 4LRAA 1EW2A 4MY4A 3UO0A 4UPHA 3B5QA 3SZZA 1N2LA 1Y7AA 5GOVA 5LRNA 1E33P 5INHA 1AJAA 1ALJA 1KHKA 2W5XA 1ELYA 4ZG7A 1HQAA 1ALHA 1P49A 1KH9A 3NKRA 3CMRA 3KD8A 1KHNA 1AJBA 1E2SP 4NWXA 2W5RA 1KH4A 3DPCA 3WBHA 3IDDA 4CXKA 3UN3A 4KJDA 1ELXA 5IJSA 1ED8A 2W8DA 3UNYA 1E1ZP 4B56A 3M8YA 4CXSA 1KHLA 4LR7A 4UPKA 5AJ9A 4UPLA 2XR9A 1ELZA 3UN5A 3MK1A 1SHQA 4FDJA 1E3CP 4LRBA 1EW8A 1ZEBA 2VQRA 2IFYA 5DLTA 4GTZA 3WAYA 4N7TA 2W5QA 3T02A 2ANHA 1ANIA 2QZUA 4GTXA 2IUCB 3WAWA 2GLQA 4ZG9A 5EGEA 5TJ3A 2W5WA 4UOPA 3SZYA 5LRMA 1ANJA 2XRGA 1EQJA 1AUKA 4UORA 4FDIA 3MK0A 2D1GA 2GSOA 1AJCA 4MHXA 3ED4A 3BDGB 2IUCA 3NKPA 4KAVA 3WAXA 1EJJA 2W5TA 3TX0A 1Y6VA 2ZKTA 5EGHA 4LR9A 1ALIA 3MK2A 1KH5A 4CYSA 5DLVA 3NVLA 4LRFA 5L0BA 2X98A 4LR2A 2GA3A 3TG0A 3NKNA 3T01A 3TWZA 4ZG6A 2W5SA 1EI6A 3NKQA 1O99A 2G9YA 3BDGA 5L0KA 3IGZB 4QAXA 3NKOA 5HRTA 3E2DA 1AJDA 3LXQA 5L0EA 3UN2A 4LQYA 4CYRA 3IGYB 2GSNA 3DYCA 5KXAA 4LRCA 5GRRA 1KH7A 5LQQA 3A52A 4CXUA 1URBA 1ALKA 3M7VA 2W8SA 3BDFA 4NWJA 1URAA 4GTWA 4UPIA 4LR8A 1SHNA 3T00A 1ZEFA 1HJKA 2W5VA 3M8WA 3M8ZA 4LREA 4ZGAA 3BDHA 1ZEDA 1B8JA 4UOOA 1HDHA 4LRDA 1EW9A 2RH6A
chains in the Genus database with same CATH topology
4KM4A 4GTYA 3Q3QA 4MIVA 5LIAA 4KJGA 5K4PA 1FSUA 1ED9A 1O98A 3NKMA 4TN0A 1K7HA 4YR1A 5DLWA 4KAYA 3WAVA 2GSUA 3OT9A 1N2KA 5IJQA 5C66A 1KHJA 4LRAA 1EW2A 4MY4A 3UO0A 4UPHA 3B5QA 3SZZA 1N2LA 1Y7AA 5GOVA 5LRNA 1E33P 5INHA 1AJAA 1ALJA 1KHKA 2W5XA 1ELYA 4ZG7A 1HQAA 1ALHA 1P49A 1KH9A 3NKRA 3CMRA 3KD8A 1KHNA 1AJBA 1E2SP 4NWXA 2W5RA 1KH4A 3DPCA 3WBHA 3IDDA 4CXKA 3UN3A 4KJDA 1ELXA 5IJSA 1ED8A 2W8DA 3UNYA 1E1ZP 4B56A 3M8YA 4CXSA 1KHLA 4LR7A 4UPKA 5AJ9A 4UPLA 2XR9A 1ELZA 3UN5A 3MK1A 1SHQA 4FDJA 1E3CP 4LRBA 1EW8A 1ZEBA 2VQRA 2IFYA 5DLTA 4GTZA 3WAYA 4N7TA 2W5QA 3T02A 2ANHA 1ANIA 2QZUA 4GTXA 2IUCB 3WAWA 2GLQA 4ZG9A 5EGEA 5TJ3A 2W5WA 4UOPA 3SZYA 5LRMA 1ANJA 2XRGA 1EQJA 1AUKA 4UORA 4FDIA 3MK0A 2D1GA 2GSOA 1AJCA 4MHXA 3ED4A 3BDGB 2IUCA 3NKPA 4KAVA 3WAXA 1EJJA 2W5TA 3TX0A 1Y6VA 2ZKTA 5EGHA 4LR9A 1ALIA 3MK2A 1KH5A 4CYSA 5DLVA 3NVLA 4LRFA 5L0BA 2X98A 4LR2A 2GA3A 3TG0A 3NKNA 3T01A 3TWZA 4ZG6A 2W5SA 1EI6A 3NKQA 1O99A 2G9YA 3BDGA 5L0KA 3IGZB 4QAXA 3NKOA 5HRTA 3E2DA 1AJDA 3LXQA 5L0EA 3UN2A 4LQYA 4CYRA 3IGYB 2GSNA 3DYCA 5KXAA 4LRCA 5GRRA 1KH7A 5LQQA 3A52A 4CXUA 1URBA 1ALKA 3M7VA 2W8SA 3BDFA 4NWJA 1URAA 4GTWA 4UPIA 4LR8A 1SHNA 3T00A 1ZEFA 1HJKA 2W5VA 3M8WA 3M8ZA 4LREA 4ZGAA 3BDHA 1ZEDA 1B8JA 4UOOA 1HDHA 4LRDA 1EW9A 2RH6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KM4 A;  4GTY A;  3Q3Q A;  4MIV A;  5LIA A;  4KJG A;  5K4P A;  1FSU A;  1ED9 A;  1O98 A;  3NKM A;  4TN0 A;  1K7H A;  4YR1 A;  5DLW A;  4KAY A;  3WAV A;  2GSU A;  3OT9 A;  1N2K A;  5IJQ A;  5C66 A;  1KHJ A;  4LRA A;  1EW2 A;  4MY4 A;  3UO0 A;  4UPH A;  3B5Q A;  3SZZ A;  1N2L A;  1Y7A A;  5GOV A;  5LRN A;  1E33 P;  5INH A;  1AJA A;  1ALJ A;  1KHK A;  2W5X A;  1ELY A;  4ZG7 A;  1HQA A;  1ALH A;  1P49 A;  1KH9 A;  3NKR A;  3CMR A;  3KD8 A;  1KHN A;  1AJB A;  1E2S P;  4NWX A;  2W5R A;  1KH4 A;  3DPC A;  3WBH A;  3IDD A;  4CXK A;  3UN3 A;  4KJD A;  1ELX A;  5IJS A;  1ED8 A;  2W8D A;  3UNY A;  1E1Z P;  4B56 A;  3M8Y A;  4CXS A;  1KHL A;  4LR7 A;  4UPK A;  5AJ9 A;  4UPL A;  2XR9 A;  1ELZ A;  3UN5 A;  3MK1 A;  1SHQ A;  4FDJ A;  1E3C P;  4LRB A;  1EW8 A;  1ZEB A;  2VQR A;  2IFY A;  5DLT A;  4GTZ A;  3WAY A;  4N7T A;  2W5Q A;  3T02 A;  2ANH A;  1ANI A;  2QZU A;  4GTX A;  2IUC B;  3WAW A;  2GLQ A;  4ZG9 A;  5EGE A;  5TJ3 A;  2W5W A;  4UOP A;  3SZY A;  5LRM A;  1ANJ A;  2XRG A;  1EQJ A;  1AUK A;  4UOR A;  4FDI A;  3MK0 A;  2D1G A;  2GSO A;  1AJC A;  4MHX A;  3ED4 A;  3BDG B;  2IUC A;  3NKP A;  4KAV A;  3WAX A;  1EJJ A;  2W5T A;  3TX0 A;  1Y6V A;  2ZKT A;  5EGH A;  4LR9 A;  1ALI A;  3MK2 A;  1KH5 A;  4CYS A;  5DLV A;  3NVL A;  4LRF A;  5L0B A;  2X98 A;  4LR2 A;  2GA3 A;  3TG0 A;  3NKN A;  3T01 A;  3TWZ A;  4ZG6 A;  2W5S A;  1EI6 A;  3NKQ A;  1O99 A;  2G9Y A;  3BDG A;  5L0K A;  3IGZ B;  4QAX A;  3NKO A;  5HRT A;  3E2D A;  1AJD A;  3LXQ A;  5L0E A;  3UN2 A;  4LQY A;  4CYR A;  3IGY B;  2GSN A;  3DYC A;  5KXA A;  4LRC A;  5GRR A;  1KH7 A;  5LQQ A;  3A52 A;  4CXU A;  1URB A;  1ALK A;  3M7V A;  2W8S A;  3BDF A;  4NWJ A;  1URA A;  4GTW A;  4UPI A;  4LR8 A;  1SHN A;  3T00 A;  1ZEF A;  1HJK A;  2W5V A;  3M8W A;  3M8Z A;  4LRE A;  4ZGA A;  3BDH A;  1ZED A;  1B8J A;  4UOO A;  1HDH A;  4LRD A;  1EW9 A;  2RH6 A; 
#chains in the Genus database with same CATH topology
 4KM4 A;  4GTY A;  3Q3Q A;  4MIV A;  5LIA A;  4KJG A;  5K4P A;  1FSU A;  1ED9 A;  1O98 A;  3NKM A;  4TN0 A;  1K7H A;  4YR1 A;  5DLW A;  4KAY A;  3WAV A;  2GSU A;  3OT9 A;  1N2K A;  5IJQ A;  5C66 A;  1KHJ A;  4LRA A;  1EW2 A;  4MY4 A;  3UO0 A;  4UPH A;  3B5Q A;  3SZZ A;  1N2L A;  1Y7A A;  5GOV A;  5LRN A;  1E33 P;  5INH A;  1AJA A;  1ALJ A;  1KHK A;  2W5X A;  1ELY A;  4ZG7 A;  1HQA A;  1ALH A;  1P49 A;  1KH9 A;  3NKR A;  3CMR A;  3KD8 A;  1KHN A;  1AJB A;  1E2S P;  4NWX A;  2W5R A;  1KH4 A;  3DPC A;  3WBH A;  3IDD A;  4CXK A;  3UN3 A;  4KJD A;  1ELX A;  5IJS A;  1ED8 A;  2W8D A;  3UNY A;  1E1Z P;  4B56 A;  3M8Y A;  4CXS A;  1KHL A;  4LR7 A;  4UPK A;  5AJ9 A;  4UPL A;  2XR9 A;  1ELZ A;  3UN5 A;  3MK1 A;  1SHQ A;  4FDJ A;  1E3C P;  4LRB A;  1EW8 A;  1ZEB A;  2VQR A;  2IFY A;  5DLT A;  4GTZ A;  3WAY A;  4N7T A;  2W5Q A;  3T02 A;  2ANH A;  1ANI A;  2QZU A;  4GTX A;  2IUC B;  3WAW A;  2GLQ A;  4ZG9 A;  5EGE A;  5TJ3 A;  2W5W A;  4UOP A;  3SZY A;  5LRM A;  1ANJ A;  2XRG A;  1EQJ A;  1AUK A;  4UOR A;  4FDI A;  3MK0 A;  2D1G A;  2GSO A;  1AJC A;  4MHX A;  3ED4 A;  3BDG B;  2IUC A;  3NKP A;  4KAV A;  3WAX A;  1EJJ A;  2W5T A;  3TX0 A;  1Y6V A;  2ZKT A;  5EGH A;  4LR9 A;  1ALI A;  3MK2 A;  1KH5 A;  4CYS A;  5DLV A;  3NVL A;  4LRF A;  5L0B A;  2X98 A;  4LR2 A;  2GA3 A;  3TG0 A;  3NKN A;  3T01 A;  3TWZ A;  4ZG6 A;  2W5S A;  1EI6 A;  3NKQ A;  1O99 A;  2G9Y A;  3BDG A;  5L0K A;  3IGZ B;  4QAX A;  3NKO A;  5HRT A;  3E2D A;  1AJD A;  3LXQ A;  5L0E A;  3UN2 A;  4LQY A;  4CYR A;  3IGY B;  2GSN A;  3DYC A;  5KXA A;  4LRC A;  5GRR A;  1KH7 A;  5LQQ A;  3A52 A;  4CXU A;  1URB A;  1ALK A;  3M7V A;  2W8S A;  3BDF A;  4NWJ A;  1URA A;  4GTW A;  4UPI A;  4LR8 A;  1SHN A;  3T00 A;  1ZEF A;  1HJK A;  2W5V A;  3M8W A;  3M8Z A;  4LRE A;  4ZGA A;  3BDH A;  1ZED A;  1B8J A;  4UOO A;  1HDH A;  4LRD A;  1EW9 A;  2RH6 A; 
#chains in the Genus database with same CATH homology
 4KM4 A;  4GTY A;  3Q3Q A;  4MIV A;  5LIA A;  4KJG A;  5K4P A;  1FSU A;  1ED9 A;  1O98 A;  3NKM A;  4TN0 A;  1K7H A;  4YR1 A;  5DLW A;  4KAY A;  3WAV A;  2GSU A;  3OT9 A;  1N2K A;  5IJQ A;  5C66 A;  1KHJ A;  4LRA A;  1EW2 A;  4MY4 A;  3UO0 A;  4UPH A;  3B5Q A;  3SZZ A;  1N2L A;  1Y7A A;  5GOV A;  5LRN A;  1E33 P;  5INH A;  1AJA A;  1ALJ A;  1KHK A;  2W5X A;  1ELY A;  4ZG7 A;  1HQA A;  1ALH A;  1P49 A;  1KH9 A;  3NKR A;  3CMR A;  3KD8 A;  1KHN A;  1AJB A;  1E2S P;  4NWX A;  2W5R A;  1KH4 A;  3DPC A;  3WBH A;  3IDD A;  4CXK A;  3UN3 A;  4KJD A;  1ELX A;  5IJS A;  1ED8 A;  2W8D A;  3UNY A;  1E1Z P;  4B56 A;  3M8Y A;  4CXS A;  1KHL A;  4LR7 A;  4UPK A;  5AJ9 A;  4UPL A;  2XR9 A;  1ELZ A;  3UN5 A;  3MK1 A;  1SHQ A;  4FDJ A;  1E3C P;  4LRB A;  1EW8 A;  1ZEB A;  2VQR A;  2IFY A;  5DLT A;  4GTZ A;  3WAY A;  4N7T A;  2W5Q A;  3T02 A;  2ANH A;  1ANI A;  2QZU A;  4GTX A;  2IUC B;  3WAW A;  2GLQ A;  4ZG9 A;  5EGE A;  5TJ3 A;  2W5W A;  4UOP A;  3SZY A;  5LRM A;  1ANJ A;  2XRG A;  1EQJ A;  1AUK A;  4UOR A;  4FDI A;  3MK0 A;  2D1G A;  2GSO A;  1AJC A;  4MHX A;  3ED4 A;  3BDG B;  2IUC A;  3NKP A;  4KAV A;  3WAX A;  1EJJ A;  2W5T A;  3TX0 A;  1Y6V A;  2ZKT A;  5EGH A;  4LR9 A;  1ALI A;  3MK2 A;  1KH5 A;  4CYS A;  5DLV A;  3NVL A;  4LRF A;  5L0B A;  2X98 A;  4LR2 A;  2GA3 A;  3TG0 A;  3NKN A;  3T01 A;  3TWZ A;  4ZG6 A;  2W5S A;  1EI6 A;  3NKQ A;  1O99 A;  2G9Y A;  3BDG A;  5L0K A;  3IGZ B;  4QAX A;  3NKO A;  5HRT A;  3E2D A;  1AJD A;  3LXQ A;  5L0E A;  3UN2 A;  4LQY A;  4CYR A;  3IGY B;  2GSN A;  3DYC A;  5KXA A;  4LRC A;  5GRR A;  1KH7 A;  5LQQ A;  3A52 A;  4CXU A;  1URB A;  1ALK A;  3M7V A;  2W8S A;  3BDF A;  4NWJ A;  1URA A;  4GTW A;  4UPI A;  4LR8 A;  1SHN A;  3T00 A;  1ZEF A;  1HJK A;  2W5V A;  3M8W A;  3M8Z A;  4LRE A;  4ZGA A;  3BDH A;  1ZED A;  1B8J A;  4UOO A;  1HDH A;  4LRD A;  1EW9 A;  2RH6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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