1EW2A

Crystal structure of a human phosphatase
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
479
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus 172
structure length 479
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
3LXQA 4ZG9A 5DLVA 1AUKA 5K4PA 3WAXA 2IUCB 2QZUA 3A52A 1ED8A 4LRAA 1ZEDA 1AJAA 1KH9A 2GSNA 2GSOA 2W5TA 4KM4A 3UNYA 5LIAA 1B8JA 1EQJA 3NVLA 4UPKA 1AJBA 1URAA 1KHLA 1N2LA 1KHKA 2GSUA 2XR9A 3M8WA 1E2SP 1E33P 1Y6VA 4ZG7A 4ZGAA 5DLWA 4MHXA 1K7HA 3SZZA 1E1ZP 4CYRA 3M8ZA 4QAXA 4TN0A 2RH6A 1KHJA 5L0EA 4MY4A 1HDHA 4LRDA 1O99A 1Y7AA 3KD8A 3NKPA 5LRNA 4GTWA 1EI6A 1ANJA 2W5WA 5LRMA 1ZEFA 1KHNA 1ALJA 3BDGA 1ZEBA 2G9YA 1ALKA 3NKRA 3NKOA 3BDGB 4NWJA 2W5QA 3NKNA 4KJDA 4UOOA 1AJCA 2W5SA 4LQYA 1ELYA 4LRCA 1ED9A 4FDJA 5L0KA 3NKQA 3CMRA 3T02A 1EW2A 2W8SA 4LR2A 1O98A 3WAWA 1URBA 4UORA 3MK2A 3IGYB 4LR7A 4CXUA 5L0BA 2ZKTA 3BDHA 4KAVA 2W5XA 4UOPA 1ELZA 4NWXA 1ALHA 3M7VA 3UN2A 5IJQA 4N7TA 1ALIA 3WAYA 1KH4A 2X98A 3TX0A 3UN3A 5INHA 4B56A 2VQRA 3Q3QA 4LRFA 5GRRA 3B5QA 4GTYA 3WBHA 5KXAA 3DPCA 3SZYA 2IUCA 4FDIA 1HQAA 4GTZA 3OT9A 4UPHA 2ANHA 1EW8A 3TG0A 4ZG6A 4LREA 1P49A 3T01A 1KH7A 4YR1A 4UPIA 3ED4A 5EGEA 3NKMA 5EGHA 1SHQA 4CXKA 5HRTA 4KAYA 4MIVA 2W8DA 5LQQA 1EJJA 3TWZA 3M8YA 3MK1A 3UN5A 5TJ3A 3WAVA 3T00A 3BDFA 1FSUA 2W5VA 5C66A 1E3CP 3UO0A 5IJSA 4GTXA 2D1GA 4LR8A 4LRBA 1ANIA 1SHNA 3E2DA 4UPLA 1KH5A 2GLQA 5AJ9A 1ELXA 1AJDA 3DYCA 3IDDA 2W5RA 3MK0A 5GOVA 1EW9A 3IGZB 4LR9A 1N2KA 1HJKA 2XRGA 2IFYA 5DLTA 4CXSA 4KJGA 4CYSA 2GA3A
chains in the Genus database with same CATH superfamily
3LXQA 4ZG9A 5DLVA 1AUKA 5K4PA 3WAXA 2IUCB 2QZUA 3A52A 1ED8A 4LRAA 1ZEDA 1AJAA 1KH9A 2GSNA 2GSOA 2W5TA 4KM4A 3UNYA 5LIAA 1B8JA 1EQJA 3NVLA 4UPKA 1AJBA 1URAA 1KHLA 1N2LA 1KHKA 2GSUA 2XR9A 3M8WA 1E2SP 1E33P 1Y6VA 4ZG7A 4ZGAA 5DLWA 4MHXA 1K7HA 3SZZA 1E1ZP 4CYRA 3M8ZA 4QAXA 4TN0A 2RH6A 1KHJA 5L0EA 4MY4A 1HDHA 4LRDA 1O99A 1Y7AA 3KD8A 3NKPA 5LRNA 4GTWA 1EI6A 1ANJA 2W5WA 5LRMA 1ZEFA 1KHNA 1ALJA 3BDGA 1ZEBA 2G9YA 1ALKA 3NKRA 3NKOA 3BDGB 4NWJA 2W5QA 3NKNA 4KJDA 4UOOA 1AJCA 2W5SA 4LQYA 1ELYA 4LRCA 1ED9A 4FDJA 5L0KA 3NKQA 3CMRA 3T02A 1EW2A 2W8SA 4LR2A 1O98A 3WAWA 1URBA 4UORA 3MK2A 3IGYB 4LR7A 4CXUA 5L0BA 2ZKTA 3BDHA 4KAVA 2W5XA 4UOPA 1ELZA 4NWXA 1ALHA 3M7VA 3UN2A 5IJQA 4N7TA 1ALIA 3WAYA 1KH4A 2X98A 3TX0A 3UN3A 5INHA 4B56A 2VQRA 3Q3QA 4LRFA 5GRRA 3B5QA 4GTYA 3WBHA 5KXAA 3DPCA 3SZYA 2IUCA 4FDIA 1HQAA 4GTZA 3OT9A 4UPHA 2ANHA 1EW8A 3TG0A 4ZG6A 4LREA 1P49A 3T01A 1KH7A 4YR1A 4UPIA 3ED4A 5EGEA 3NKMA 5EGHA 1SHQA 4CXKA 5HRTA 4KAYA 4MIVA 2W8DA 5LQQA 1EJJA 3TWZA 3M8YA 3MK1A 3UN5A 5TJ3A 3WAVA 3T00A 3BDFA 1FSUA 2W5VA 5C66A 1E3CP 3UO0A 5IJSA 4GTXA 2D1GA 4LR8A 4LRBA 1ANIA 1SHNA 3E2DA 4UPLA 1KH5A 2GLQA 5AJ9A 1ELXA 1AJDA 3DYCA 3IDDA 2W5RA 3MK0A 5GOVA 1EW9A 3IGZB 4LR9A 1N2KA 1HJKA 2XRGA 2IFYA 5DLTA 4CXSA 4KJGA 4CYSA 2GA3A
chains in the Genus database with same CATH topology
3LXQA 4ZG9A 5DLVA 1AUKA 5K4PA 3WAXA 2IUCB 2QZUA 3A52A 1ED8A 4LRAA 1ZEDA 1AJAA 1KH9A 2GSNA 2GSOA 2W5TA 4KM4A 3UNYA 5LIAA 1B8JA 1EQJA 3NVLA 4UPKA 1AJBA 1URAA 1KHLA 1N2LA 1KHKA 2GSUA 2XR9A 3M8WA 1E2SP 1E33P 1Y6VA 4ZG7A 4ZGAA 5DLWA 4MHXA 1K7HA 3SZZA 1E1ZP 4CYRA 3M8ZA 4QAXA 4TN0A 2RH6A 1KHJA 5L0EA 4MY4A 1HDHA 4LRDA 1O99A 1Y7AA 3KD8A 3NKPA 5LRNA 4GTWA 1EI6A 1ANJA 2W5WA 5LRMA 1ZEFA 1KHNA 1ALJA 3BDGA 1ZEBA 2G9YA 1ALKA 3NKRA 3NKOA 3BDGB 4NWJA 2W5QA 3NKNA 4KJDA 4UOOA 1AJCA 2W5SA 4LQYA 1ELYA 4LRCA 1ED9A 4FDJA 5L0KA 3NKQA 3CMRA 3T02A 1EW2A 2W8SA 4LR2A 1O98A 3WAWA 1URBA 4UORA 3MK2A 3IGYB 4LR7A 4CXUA 5L0BA 2ZKTA 3BDHA 4KAVA 2W5XA 4UOPA 1ELZA 4NWXA 1ALHA 3M7VA 3UN2A 5IJQA 4N7TA 1ALIA 3WAYA 1KH4A 2X98A 3TX0A 3UN3A 5INHA 4B56A 2VQRA 3Q3QA 4LRFA 5GRRA 3B5QA 4GTYA 3WBHA 5KXAA 3DPCA 3SZYA 2IUCA 4FDIA 1HQAA 4GTZA 3OT9A 4UPHA 2ANHA 1EW8A 3TG0A 4ZG6A 4LREA 1P49A 3T01A 1KH7A 4YR1A 4UPIA 3ED4A 5EGEA 3NKMA 5EGHA 1SHQA 4CXKA 5HRTA 4KAYA 4MIVA 2W8DA 5LQQA 1EJJA 3TWZA 3M8YA 3MK1A 3UN5A 5TJ3A 3WAVA 3T00A 3BDFA 1FSUA 2W5VA 5C66A 1E3CP 3UO0A 5IJSA 4GTXA 2D1GA 4LR8A 4LRBA 1ANIA 1SHNA 3E2DA 4UPLA 1KH5A 2GLQA 5AJ9A 1ELXA 1AJDA 3DYCA 3IDDA 2W5RA 3MK0A 5GOVA 1EW9A 3IGZB 4LR9A 1N2KA 1HJKA 2XRGA 2IFYA 5DLTA 4CXSA 4KJGA 4CYSA 2GA3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LXQ A;  4ZG9 A;  5DLV A;  1AUK A;  5K4P A;  3WAX A;  2IUC B;  2QZU A;  3A52 A;  1ED8 A;  4LRA A;  1ZED A;  1AJA A;  1KH9 A;  2GSN A;  2GSO A;  2W5T A;  4KM4 A;  3UNY A;  5LIA A;  1B8J A;  1EQJ A;  3NVL A;  4UPK A;  1AJB A;  1URA A;  1KHL A;  1N2L A;  1KHK A;  2GSU A;  2XR9 A;  3M8W A;  1E2S P;  1E33 P;  1Y6V A;  4ZG7 A;  4ZGA A;  5DLW A;  4MHX A;  1K7H A;  3SZZ A;  1E1Z P;  4CYR A;  3M8Z A;  4QAX A;  4TN0 A;  2RH6 A;  1KHJ A;  5L0E A;  4MY4 A;  1HDH A;  4LRD A;  1O99 A;  1Y7A A;  3KD8 A;  3NKP A;  5LRN A;  4GTW A;  1EI6 A;  1ANJ A;  2W5W A;  5LRM A;  1ZEF A;  1KHN A;  1ALJ A;  3BDG A;  1ZEB A;  2G9Y A;  1ALK A;  3NKR A;  3NKO A;  3BDG B;  4NWJ A;  2W5Q A;  3NKN A;  4KJD A;  4UOO A;  1AJC A;  2W5S A;  4LQY A;  1ELY A;  4LRC A;  1ED9 A;  4FDJ A;  5L0K A;  3NKQ A;  3CMR A;  3T02 A;  1EW2 A;  2W8S A;  4LR2 A;  1O98 A;  3WAW A;  1URB A;  4UOR A;  3MK2 A;  3IGY B;  4LR7 A;  4CXU A;  5L0B A;  2ZKT A;  3BDH A;  4KAV A;  2W5X A;  4UOP A;  1ELZ A;  4NWX A;  1ALH A;  3M7V A;  3UN2 A;  5IJQ A;  4N7T A;  1ALI A;  3WAY A;  1KH4 A;  2X98 A;  3TX0 A;  3UN3 A;  5INH A;  4B56 A;  2VQR A;  3Q3Q A;  4LRF A;  5GRR A;  3B5Q A;  4GTY A;  3WBH A;  5KXA A;  3DPC A;  3SZY A;  2IUC A;  4FDI A;  1HQA A;  4GTZ A;  3OT9 A;  4UPH A;  2ANH A;  1EW8 A;  3TG0 A;  4ZG6 A;  4LRE A;  1P49 A;  3T01 A;  1KH7 A;  4YR1 A;  4UPI A;  3ED4 A;  5EGE A;  3NKM A;  5EGH A;  1SHQ A;  4CXK A;  5HRT A;  4KAY A;  4MIV A;  2W8D A;  5LQQ A;  1EJJ A;  3TWZ A;  3M8Y A;  3MK1 A;  3UN5 A;  5TJ3 A;  3WAV A;  3T00 A;  3BDF A;  1FSU A;  2W5V A;  5C66 A;  1E3C P;  3UO0 A;  5IJS A;  4GTX A;  2D1G A;  4LR8 A;  4LRB A;  1ANI A;  1SHN A;  3E2D A;  4UPL A;  1KH5 A;  2GLQ A;  5AJ9 A;  1ELX A;  1AJD A;  3DYC A;  3IDD A;  2W5R A;  3MK0 A;  5GOV A;  1EW9 A;  3IGZ B;  4LR9 A;  1N2K A;  1HJK A;  2XRG A;  2IFY A;  5DLT A;  4CXS A;  4KJG A;  4CYS A;  2GA3 A; 
#chains in the Genus database with same CATH topology
 3LXQ A;  4ZG9 A;  5DLV A;  1AUK A;  5K4P A;  3WAX A;  2IUC B;  2QZU A;  3A52 A;  1ED8 A;  4LRA A;  1ZED A;  1AJA A;  1KH9 A;  2GSN A;  2GSO A;  2W5T A;  4KM4 A;  3UNY A;  5LIA A;  1B8J A;  1EQJ A;  3NVL A;  4UPK A;  1AJB A;  1URA A;  1KHL A;  1N2L A;  1KHK A;  2GSU A;  2XR9 A;  3M8W A;  1E2S P;  1E33 P;  1Y6V A;  4ZG7 A;  4ZGA A;  5DLW A;  4MHX A;  1K7H A;  3SZZ A;  1E1Z P;  4CYR A;  3M8Z A;  4QAX A;  4TN0 A;  2RH6 A;  1KHJ A;  5L0E A;  4MY4 A;  1HDH A;  4LRD A;  1O99 A;  1Y7A A;  3KD8 A;  3NKP A;  5LRN A;  4GTW A;  1EI6 A;  1ANJ A;  2W5W A;  5LRM A;  1ZEF A;  1KHN A;  1ALJ A;  3BDG A;  1ZEB A;  2G9Y A;  1ALK A;  3NKR A;  3NKO A;  3BDG B;  4NWJ A;  2W5Q A;  3NKN A;  4KJD A;  4UOO A;  1AJC A;  2W5S A;  4LQY A;  1ELY A;  4LRC A;  1ED9 A;  4FDJ A;  5L0K A;  3NKQ A;  3CMR A;  3T02 A;  1EW2 A;  2W8S A;  4LR2 A;  1O98 A;  3WAW A;  1URB A;  4UOR A;  3MK2 A;  3IGY B;  4LR7 A;  4CXU A;  5L0B A;  2ZKT A;  3BDH A;  4KAV A;  2W5X A;  4UOP A;  1ELZ A;  4NWX A;  1ALH A;  3M7V A;  3UN2 A;  5IJQ A;  4N7T A;  1ALI A;  3WAY A;  1KH4 A;  2X98 A;  3TX0 A;  3UN3 A;  5INH A;  4B56 A;  2VQR A;  3Q3Q A;  4LRF A;  5GRR A;  3B5Q A;  4GTY A;  3WBH A;  5KXA A;  3DPC A;  3SZY A;  2IUC A;  4FDI A;  1HQA A;  4GTZ A;  3OT9 A;  4UPH A;  2ANH A;  1EW8 A;  3TG0 A;  4ZG6 A;  4LRE A;  1P49 A;  3T01 A;  1KH7 A;  4YR1 A;  4UPI A;  3ED4 A;  5EGE A;  3NKM A;  5EGH A;  1SHQ A;  4CXK A;  5HRT A;  4KAY A;  4MIV A;  2W8D A;  5LQQ A;  1EJJ A;  3TWZ A;  3M8Y A;  3MK1 A;  3UN5 A;  5TJ3 A;  3WAV A;  3T00 A;  3BDF A;  1FSU A;  2W5V A;  5C66 A;  1E3C P;  3UO0 A;  5IJS A;  4GTX A;  2D1G A;  4LR8 A;  4LRB A;  1ANI A;  1SHN A;  3E2D A;  4UPL A;  1KH5 A;  2GLQ A;  5AJ9 A;  1ELX A;  1AJD A;  3DYC A;  3IDD A;  2W5R A;  3MK0 A;  5GOV A;  1EW9 A;  3IGZ B;  4LR9 A;  1N2K A;  1HJK A;  2XRG A;  2IFY A;  5DLT A;  4CXS A;  4KJG A;  4CYS A;  2GA3 A; 
#chains in the Genus database with same CATH homology
 3LXQ A;  4ZG9 A;  5DLV A;  1AUK A;  5K4P A;  3WAX A;  2IUC B;  2QZU A;  3A52 A;  1ED8 A;  4LRA A;  1ZED A;  1AJA A;  1KH9 A;  2GSN A;  2GSO A;  2W5T A;  4KM4 A;  3UNY A;  5LIA A;  1B8J A;  1EQJ A;  3NVL A;  4UPK A;  1AJB A;  1URA A;  1KHL A;  1N2L A;  1KHK A;  2GSU A;  2XR9 A;  3M8W A;  1E2S P;  1E33 P;  1Y6V A;  4ZG7 A;  4ZGA A;  5DLW A;  4MHX A;  1K7H A;  3SZZ A;  1E1Z P;  4CYR A;  3M8Z A;  4QAX A;  4TN0 A;  2RH6 A;  1KHJ A;  5L0E A;  4MY4 A;  1HDH A;  4LRD A;  1O99 A;  1Y7A A;  3KD8 A;  3NKP A;  5LRN A;  4GTW A;  1EI6 A;  1ANJ A;  2W5W A;  5LRM A;  1ZEF A;  1KHN A;  1ALJ A;  3BDG A;  1ZEB A;  2G9Y A;  1ALK A;  3NKR A;  3NKO A;  3BDG B;  4NWJ A;  2W5Q A;  3NKN A;  4KJD A;  4UOO A;  1AJC A;  2W5S A;  4LQY A;  1ELY A;  4LRC A;  1ED9 A;  4FDJ A;  5L0K A;  3NKQ A;  3CMR A;  3T02 A;  1EW2 A;  2W8S A;  4LR2 A;  1O98 A;  3WAW A;  1URB A;  4UOR A;  3MK2 A;  3IGY B;  4LR7 A;  4CXU A;  5L0B A;  2ZKT A;  3BDH A;  4KAV A;  2W5X A;  4UOP A;  1ELZ A;  4NWX A;  1ALH A;  3M7V A;  3UN2 A;  5IJQ A;  4N7T A;  1ALI A;  3WAY A;  1KH4 A;  2X98 A;  3TX0 A;  3UN3 A;  5INH A;  4B56 A;  2VQR A;  3Q3Q A;  4LRF A;  5GRR A;  3B5Q A;  4GTY A;  3WBH A;  5KXA A;  3DPC A;  3SZY A;  2IUC A;  4FDI A;  1HQA A;  4GTZ A;  3OT9 A;  4UPH A;  2ANH A;  1EW8 A;  3TG0 A;  4ZG6 A;  4LRE A;  1P49 A;  3T01 A;  1KH7 A;  4YR1 A;  4UPI A;  3ED4 A;  5EGE A;  3NKM A;  5EGH A;  1SHQ A;  4CXK A;  5HRT A;  4KAY A;  4MIV A;  2W8D A;  5LQQ A;  1EJJ A;  3TWZ A;  3M8Y A;  3MK1 A;  3UN5 A;  5TJ3 A;  3WAV A;  3T00 A;  3BDF A;  1FSU A;  2W5V A;  5C66 A;  1E3C P;  3UO0 A;  5IJS A;  4GTX A;  2D1G A;  4LR8 A;  4LRB A;  1ANI A;  1SHN A;  3E2D A;  4UPL A;  1KH5 A;  2GLQ A;  5AJ9 A;  1ELX A;  1AJD A;  3DYC A;  3IDD A;  2W5R A;  3MK0 A;  5GOV A;  1EW9 A;  3IGZ B;  4LR9 A;  1N2K A;  1HJK A;  2XRG A;  2IFY A;  5DLT A;  4CXS A;  4KJG A;  4CYS A;  2GA3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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