1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
5INHA 4GTZA 4ZG7A 1E3CP 4UOOA 1HQAA 3MK2A 4LRBA 1ALJA 4LR9A 3BDGB 5C66A 1N2KA 5TJ3A 5AJ9A 3CMRA 3Q3QA 4UOPA 5LRMA 1AJDA 1P49A 4QAXA 2RH6A 3UN5A 1ANJA 1ZEBA 4MHXA 3WAVA 1K7HA 1KHLA 3TG0A 1EI6A 1URBA 3M7VA 4LR7A 2D1GA 3WAWA 5LRNA 1ELXA 1ANIA 2W5RA 3ED4A 2ANHA 1ELZA 1SHNA 2VQRA 4LQYA 1ELYA 2GSUA 4CXKA 5HRTA 1EW8A 5LIAA 2W8DA 3T00A 1FSUA 4KM4A 1B8JA 3A52A 2GLQA 4N7TA 4B56A 1URAA 3TX0A 3M8WA 3UN2A 4CYSA 5DLWA 3SZZA 3NKMA 4KJDA 1E2SP 2QZUA 1EW2A 3DYCA 4LRDA 1ED8A 1O98A 1KHNA 1O99A 3NKNA 4CXSA 4LR8A 3T02A 5DLTA 2X98A 1EJJA 1KH7A 3MK1A 1KHJA 1ZEFA 1Y6VA 3T01A 1N2LA 3UN3A 3NKOA 3IGYB 5LQQA 2W5QA 4UPLA 2W5XA 2GSNA 3DPCA 1HDHA 5GOVA 3TWZA 5DLVA 3NKPA 3MK0A 1ALIA 3WBHA 4GTWA 1ALKA 5K4PA 3IDDA 1EQJA 3OT9A 1ALHA 1EW9A 4KAYA 3M8ZA 3E2DA 2GSOA 2IUCB 1ED9A 2W5SA 1KH5A 3IGZB 1KHKA 5EGHA 3UO0A 3NKQA 4MIVA 1AUKA 5L0EA 4ZG6A 2ZKTA 1SHQA 3KD8A 4FDIA 4LRAA 3LXQA 4GTXA 4UPIA 4UPKA 5GRRA 4ZGAA 3M8YA 2GA3A 3B5QA 4FDJA 4CYRA 2W5VA 1AJBA 1HJKA 3UNYA 4KJGA 5KXAA 5IJSA 4LRCA 3WAXA 5L0KA 1AJAA 1E33P 2XR9A 4LR2A 3WAYA 3BDGA 4LREA 5L0BA 1KH9A 4NWXA 2W5TA 1E1ZP 3BDHA 4GTYA 4UPHA 3BDFA 2XRGA 4UORA 4ZG9A 4KAVA 1Y7AA 4MY4A 3NKRA 2G9YA 1ZEDA 4YR1A 5EGEA 4NWJA 5IJQA 1KH4A 2IUCA 3NVLA 2W5WA 4TN0A 4CXUA 1AJCA 4LRFA 3SZYA 2W8SA 2IFYA
chains in the Genus database with same CATH superfamily
5INHA 4GTZA 4ZG7A 1E3CP 4UOOA 1HQAA 3MK2A 4LRBA 1ALJA 4LR9A 3BDGB 5C66A 1N2KA 5TJ3A 5AJ9A 3CMRA 3Q3QA 4UOPA 5LRMA 1AJDA 1P49A 4QAXA 2RH6A 3UN5A 1ANJA 1ZEBA 4MHXA 3WAVA 1K7HA 1KHLA 3TG0A 1EI6A 1URBA 3M7VA 4LR7A 2D1GA 3WAWA 5LRNA 1ELXA 1ANIA 2W5RA 3ED4A 2ANHA 1ELZA 1SHNA 2VQRA 4LQYA 1ELYA 2GSUA 4CXKA 5HRTA 1EW8A 5LIAA 2W8DA 3T00A 1FSUA 4KM4A 1B8JA 3A52A 2GLQA 4N7TA 4B56A 1URAA 3TX0A 3M8WA 3UN2A 4CYSA 5DLWA 3SZZA 3NKMA 4KJDA 1E2SP 2QZUA 1EW2A 3DYCA 4LRDA 1ED8A 1O98A 1KHNA 1O99A 3NKNA 4CXSA 4LR8A 3T02A 5DLTA 2X98A 1EJJA 1KH7A 3MK1A 1KHJA 1ZEFA 1Y6VA 3T01A 1N2LA 3UN3A 3NKOA 3IGYB 5LQQA 2W5QA 4UPLA 2W5XA 2GSNA 3DPCA 1HDHA 5GOVA 3TWZA 5DLVA 3NKPA 3MK0A 1ALIA 3WBHA 4GTWA 1ALKA 5K4PA 3IDDA 1EQJA 3OT9A 1ALHA 1EW9A 4KAYA 3M8ZA 3E2DA 2GSOA 2IUCB 1ED9A 2W5SA 1KH5A 3IGZB 1KHKA 5EGHA 3UO0A 3NKQA 4MIVA 1AUKA 5L0EA 4ZG6A 2ZKTA 1SHQA 3KD8A 4FDIA 4LRAA 3LXQA 4GTXA 4UPIA 4UPKA 5GRRA 4ZGAA 3M8YA 2GA3A 3B5QA 4FDJA 4CYRA 2W5VA 1AJBA 1HJKA 3UNYA 4KJGA 5KXAA 5IJSA 4LRCA 3WAXA 5L0KA 1AJAA 1E33P 2XR9A 4LR2A 3WAYA 3BDGA 4LREA 5L0BA 1KH9A 4NWXA 2W5TA 1E1ZP 3BDHA 4GTYA 4UPHA 3BDFA 2XRGA 4UORA 4ZG9A 4KAVA 1Y7AA 4MY4A 3NKRA 2G9YA 1ZEDA 4YR1A 5EGEA 4NWJA 5IJQA 1KH4A 2IUCA 3NVLA 2W5WA 4TN0A 4CXUA 1AJCA 4LRFA 3SZYA 2W8SA 2IFYA
chains in the Genus database with same CATH topology
5INHA 4GTZA 4ZG7A 1E3CP 4UOOA 1HQAA 3MK2A 4LRBA 1ALJA 4LR9A 3BDGB 5C66A 1N2KA 5TJ3A 5AJ9A 3CMRA 3Q3QA 4UOPA 5LRMA 1AJDA 1P49A 4QAXA 2RH6A 3UN5A 1ANJA 1ZEBA 4MHXA 3WAVA 1K7HA 1KHLA 3TG0A 1EI6A 1URBA 3M7VA 4LR7A 2D1GA 3WAWA 5LRNA 1ELXA 1ANIA 2W5RA 3ED4A 2ANHA 1ELZA 1SHNA 2VQRA 4LQYA 1ELYA 2GSUA 4CXKA 5HRTA 1EW8A 5LIAA 2W8DA 3T00A 1FSUA 4KM4A 1B8JA 3A52A 2GLQA 4N7TA 4B56A 1URAA 3TX0A 3M8WA 3UN2A 4CYSA 5DLWA 3SZZA 3NKMA 4KJDA 1E2SP 2QZUA 1EW2A 3DYCA 4LRDA 1ED8A 1O98A 1KHNA 1O99A 3NKNA 4CXSA 4LR8A 3T02A 5DLTA 2X98A 1EJJA 1KH7A 3MK1A 1KHJA 1ZEFA 1Y6VA 3T01A 1N2LA 3UN3A 3NKOA 3IGYB 5LQQA 2W5QA 4UPLA 2W5XA 2GSNA 3DPCA 1HDHA 5GOVA 3TWZA 5DLVA 3NKPA 3MK0A 1ALIA 3WBHA 4GTWA 1ALKA 5K4PA 3IDDA 1EQJA 3OT9A 1ALHA 1EW9A 4KAYA 3M8ZA 3E2DA 2GSOA 2IUCB 1ED9A 2W5SA 1KH5A 3IGZB 1KHKA 5EGHA 3UO0A 3NKQA 4MIVA 1AUKA 5L0EA 4ZG6A 2ZKTA 1SHQA 3KD8A 4FDIA 4LRAA 3LXQA 4GTXA 4UPIA 4UPKA 5GRRA 4ZGAA 3M8YA 2GA3A 3B5QA 4FDJA 4CYRA 2W5VA 1AJBA 1HJKA 3UNYA 4KJGA 5KXAA 5IJSA 4LRCA 3WAXA 5L0KA 1AJAA 1E33P 2XR9A 4LR2A 3WAYA 3BDGA 4LREA 5L0BA 1KH9A 4NWXA 2W5TA 1E1ZP 3BDHA 4GTYA 4UPHA 3BDFA 2XRGA 4UORA 4ZG9A 4KAVA 1Y7AA 4MY4A 3NKRA 2G9YA 1ZEDA 4YR1A 5EGEA 4NWJA 5IJQA 1KH4A 2IUCA 3NVLA 2W5WA 4TN0A 4CXUA 1AJCA 4LRFA 3SZYA 2W8SA 2IFYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5INH A;  4GTZ A;  4ZG7 A;  1E3C P;  4UOO A;  1HQA A;  3MK2 A;  4LRB A;  1ALJ A;  4LR9 A;  3BDG B;  5C66 A;  1N2K A;  5TJ3 A;  5AJ9 A;  3CMR A;  3Q3Q A;  4UOP A;  5LRM A;  1AJD A;  1P49 A;  4QAX A;  2RH6 A;  3UN5 A;  1ANJ A;  1ZEB A;  4MHX A;  3WAV A;  1K7H A;  1KHL A;  3TG0 A;  1EI6 A;  1URB A;  3M7V A;  4LR7 A;  2D1G A;  3WAW A;  5LRN A;  1ELX A;  1ANI A;  2W5R A;  3ED4 A;  2ANH A;  1ELZ A;  1SHN A;  2VQR A;  4LQY A;  1ELY A;  2GSU A;  4CXK A;  5HRT A;  1EW8 A;  5LIA A;  2W8D A;  3T00 A;  1FSU A;  4KM4 A;  1B8J A;  3A52 A;  2GLQ A;  4N7T A;  4B56 A;  1URA A;  3TX0 A;  3M8W A;  3UN2 A;  4CYS A;  5DLW A;  3SZZ A;  3NKM A;  4KJD A;  1E2S P;  2QZU A;  1EW2 A;  3DYC A;  4LRD A;  1ED8 A;  1O98 A;  1KHN A;  1O99 A;  3NKN A;  4CXS A;  4LR8 A;  3T02 A;  5DLT A;  2X98 A;  1EJJ A;  1KH7 A;  3MK1 A;  1KHJ A;  1ZEF A;  1Y6V A;  3T01 A;  1N2L A;  3UN3 A;  3NKO A;  3IGY B;  5LQQ A;  2W5Q A;  4UPL A;  2W5X A;  2GSN A;  3DPC A;  1HDH A;  5GOV A;  3TWZ A;  5DLV A;  3NKP A;  3MK0 A;  1ALI A;  3WBH A;  4GTW A;  1ALK A;  5K4P A;  3IDD A;  1EQJ A;  3OT9 A;  1ALH A;  1EW9 A;  4KAY A;  3M8Z A;  3E2D A;  2GSO A;  2IUC B;  1ED9 A;  2W5S A;  1KH5 A;  3IGZ B;  1KHK A;  5EGH A;  3UO0 A;  3NKQ A;  4MIV A;  1AUK A;  5L0E A;  4ZG6 A;  2ZKT A;  1SHQ A;  3KD8 A;  4FDI A;  4LRA A;  3LXQ A;  4GTX A;  4UPI A;  4UPK A;  5GRR A;  4ZGA A;  3M8Y A;  2GA3 A;  3B5Q A;  4FDJ A;  4CYR A;  2W5V A;  1AJB A;  1HJK A;  3UNY A;  4KJG A;  5KXA A;  5IJS A;  4LRC A;  3WAX A;  5L0K A;  1AJA A;  1E33 P;  2XR9 A;  4LR2 A;  3WAY A;  3BDG A;  4LRE A;  5L0B A;  1KH9 A;  4NWX A;  2W5T A;  1E1Z P;  3BDH A;  4GTY A;  4UPH A;  3BDF A;  2XRG A;  4UOR A;  4ZG9 A;  4KAV A;  1Y7A A;  4MY4 A;  3NKR A;  2G9Y A;  1ZED A;  4YR1 A;  5EGE A;  4NWJ A;  5IJQ A;  1KH4 A;  2IUC A;  3NVL A;  2W5W A;  4TN0 A;  4CXU A;  1AJC A;  4LRF A;  3SZY A;  2W8S A;  2IFY A; 
#chains in the Genus database with same CATH topology
 5INH A;  4GTZ A;  4ZG7 A;  1E3C P;  4UOO A;  1HQA A;  3MK2 A;  4LRB A;  1ALJ A;  4LR9 A;  3BDG B;  5C66 A;  1N2K A;  5TJ3 A;  5AJ9 A;  3CMR A;  3Q3Q A;  4UOP A;  5LRM A;  1AJD A;  1P49 A;  4QAX A;  2RH6 A;  3UN5 A;  1ANJ A;  1ZEB A;  4MHX A;  3WAV A;  1K7H A;  1KHL A;  3TG0 A;  1EI6 A;  1URB A;  3M7V A;  4LR7 A;  2D1G A;  3WAW A;  5LRN A;  1ELX A;  1ANI A;  2W5R A;  3ED4 A;  2ANH A;  1ELZ A;  1SHN A;  2VQR A;  4LQY A;  1ELY A;  2GSU A;  4CXK A;  5HRT A;  1EW8 A;  5LIA A;  2W8D A;  3T00 A;  1FSU A;  4KM4 A;  1B8J A;  3A52 A;  2GLQ A;  4N7T A;  4B56 A;  1URA A;  3TX0 A;  3M8W A;  3UN2 A;  4CYS A;  5DLW A;  3SZZ A;  3NKM A;  4KJD A;  1E2S P;  2QZU A;  1EW2 A;  3DYC A;  4LRD A;  1ED8 A;  1O98 A;  1KHN A;  1O99 A;  3NKN A;  4CXS A;  4LR8 A;  3T02 A;  5DLT A;  2X98 A;  1EJJ A;  1KH7 A;  3MK1 A;  1KHJ A;  1ZEF A;  1Y6V A;  3T01 A;  1N2L A;  3UN3 A;  3NKO A;  3IGY B;  5LQQ A;  2W5Q A;  4UPL A;  2W5X A;  2GSN A;  3DPC A;  1HDH A;  5GOV A;  3TWZ A;  5DLV A;  3NKP A;  3MK0 A;  1ALI A;  3WBH A;  4GTW A;  1ALK A;  5K4P A;  3IDD A;  1EQJ A;  3OT9 A;  1ALH A;  1EW9 A;  4KAY A;  3M8Z A;  3E2D A;  2GSO A;  2IUC B;  1ED9 A;  2W5S A;  1KH5 A;  3IGZ B;  1KHK A;  5EGH A;  3UO0 A;  3NKQ A;  4MIV A;  1AUK A;  5L0E A;  4ZG6 A;  2ZKT A;  1SHQ A;  3KD8 A;  4FDI A;  4LRA A;  3LXQ A;  4GTX A;  4UPI A;  4UPK A;  5GRR A;  4ZGA A;  3M8Y A;  2GA3 A;  3B5Q A;  4FDJ A;  4CYR A;  2W5V A;  1AJB A;  1HJK A;  3UNY A;  4KJG A;  5KXA A;  5IJS A;  4LRC A;  3WAX A;  5L0K A;  1AJA A;  1E33 P;  2XR9 A;  4LR2 A;  3WAY A;  3BDG A;  4LRE A;  5L0B A;  1KH9 A;  4NWX A;  2W5T A;  1E1Z P;  3BDH A;  4GTY A;  4UPH A;  3BDF A;  2XRG A;  4UOR A;  4ZG9 A;  4KAV A;  1Y7A A;  4MY4 A;  3NKR A;  2G9Y A;  1ZED A;  4YR1 A;  5EGE A;  4NWJ A;  5IJQ A;  1KH4 A;  2IUC A;  3NVL A;  2W5W A;  4TN0 A;  4CXU A;  1AJC A;  4LRF A;  3SZY A;  2W8S A;  2IFY A; 
#chains in the Genus database with same CATH homology
 5INH A;  4GTZ A;  4ZG7 A;  1E3C P;  4UOO A;  1HQA A;  3MK2 A;  4LRB A;  1ALJ A;  4LR9 A;  3BDG B;  5C66 A;  1N2K A;  5TJ3 A;  5AJ9 A;  3CMR A;  3Q3Q A;  4UOP A;  5LRM A;  1AJD A;  1P49 A;  4QAX A;  2RH6 A;  3UN5 A;  1ANJ A;  1ZEB A;  4MHX A;  3WAV A;  1K7H A;  1KHL A;  3TG0 A;  1EI6 A;  1URB A;  3M7V A;  4LR7 A;  2D1G A;  3WAW A;  5LRN A;  1ELX A;  1ANI A;  2W5R A;  3ED4 A;  2ANH A;  1ELZ A;  1SHN A;  2VQR A;  4LQY A;  1ELY A;  2GSU A;  4CXK A;  5HRT A;  1EW8 A;  5LIA A;  2W8D A;  3T00 A;  1FSU A;  4KM4 A;  1B8J A;  3A52 A;  2GLQ A;  4N7T A;  4B56 A;  1URA A;  3TX0 A;  3M8W A;  3UN2 A;  4CYS A;  5DLW A;  3SZZ A;  3NKM A;  4KJD A;  1E2S P;  2QZU A;  1EW2 A;  3DYC A;  4LRD A;  1ED8 A;  1O98 A;  1KHN A;  1O99 A;  3NKN A;  4CXS A;  4LR8 A;  3T02 A;  5DLT A;  2X98 A;  1EJJ A;  1KH7 A;  3MK1 A;  1KHJ A;  1ZEF A;  1Y6V A;  3T01 A;  1N2L A;  3UN3 A;  3NKO A;  3IGY B;  5LQQ A;  2W5Q A;  4UPL A;  2W5X A;  2GSN A;  3DPC A;  1HDH A;  5GOV A;  3TWZ A;  5DLV A;  3NKP A;  3MK0 A;  1ALI A;  3WBH A;  4GTW A;  1ALK A;  5K4P A;  3IDD A;  1EQJ A;  3OT9 A;  1ALH A;  1EW9 A;  4KAY A;  3M8Z A;  3E2D A;  2GSO A;  2IUC B;  1ED9 A;  2W5S A;  1KH5 A;  3IGZ B;  1KHK A;  5EGH A;  3UO0 A;  3NKQ A;  4MIV A;  1AUK A;  5L0E A;  4ZG6 A;  2ZKT A;  1SHQ A;  3KD8 A;  4FDI A;  4LRA A;  3LXQ A;  4GTX A;  4UPI A;  4UPK A;  5GRR A;  4ZGA A;  3M8Y A;  2GA3 A;  3B5Q A;  4FDJ A;  4CYR A;  2W5V A;  1AJB A;  1HJK A;  3UNY A;  4KJG A;  5KXA A;  5IJS A;  4LRC A;  3WAX A;  5L0K A;  1AJA A;  1E33 P;  2XR9 A;  4LR2 A;  3WAY A;  3BDG A;  4LRE A;  5L0B A;  1KH9 A;  4NWX A;  2W5T A;  1E1Z P;  3BDH A;  4GTY A;  4UPH A;  3BDF A;  2XRG A;  4UOR A;  4ZG9 A;  4KAV A;  1Y7A A;  4MY4 A;  3NKR A;  2G9Y A;  1ZED A;  4YR1 A;  5EGE A;  4NWJ A;  5IJQ A;  1KH4 A;  2IUC A;  3NVL A;  2W5W A;  4TN0 A;  4CXU A;  1AJC A;  4LRF A;  3SZY A;  2W8S A;  2IFY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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