1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
4LR7A 3M8ZA 2IFYA 3T00A 1B8JA 1AJDA 5KXAA 4CXUA 4N7TA 4B56A 5C66A 3UN2A 3TG0A 4KAYA 1HDHA 1AJCA 3IGYB 4YR1A 5INHA 5IJSA 2W8SA 5EGEA 4LRCA 4UPKA 3NKPA 2GSOA 3WAVA 4UORA 2W5VA 1O98A 3UNYA 2XR9A 4GTYA 1HJKA 4UPLA 4UOPA 4LR2A 1ALJA 3SZYA 2IUCB 4LRAA 4CXKA 1ZEFA 1Y7AA 4NWXA 3BDGA 1EW2A 1O99A 2D1GA 5LRMA 1E1ZP 3WBHA 2GSNA 4LR8A 4KJGA 4ZG9A 5HRTA 1URBA 1ANIA 3NKRA 2GA3A 4CYSA 2XRGA 1EI6A 4TN0A 4KAVA 3Q3QA 1ZEDA 1FSUA 3WAYA 3M8WA 3IDDA 5IJQA 2QZUA 5LRNA 4GTWA 4LREA 2G9YA 4ZG7A 3ED4A 5DLVA 2ZKTA 1ALKA 3OT9A 4UPHA 5L0EA 2W5XA 2VQRA 1E33P 3KD8A 3M8YA 2W5SA 3NVLA 2IUCA 5EGHA 3UO0A 4CYRA 4UOOA 4ZGAA 4NWJA 5LIAA 4KM4A 3MK0A 4LRBA 1KHLA 4MHXA 1HQAA 3NKOA 5L0BA 5K4PA 4FDJA 4CXSA 3TX0A 1URAA 3B5QA 1KH7A 3M7VA 1ANJA 1E2SP 1EQJA 1ELXA 1P49A 3DYCA 1ELZA 3UN5A 2W5WA 1E3CP 2GSUA 2GLQA 3MK1A 1KHJA 2W8DA 1AJAA 2ANHA 3CMRA 3IGZB 1KH5A 3MK2A 4UPIA 5AJ9A 1N2LA 1KH4A 3E2DA 1SHQA 1AJBA 5DLTA 3WAWA 1EW8A 3NKQA 4GTZA 1ELYA 2W5QA 4LQYA 4MIVA 5L0KA 4KJDA 1KH9A 3TWZA 4FDIA 2W5RA 1ZEBA 5GOVA 1ED9A 1ALHA 3NKMA 4QAXA 3LXQA 4LRFA 3SZZA 5DLWA 1KHKA 3BDHA 3UN3A 1EJJA 3NKNA 4ZG6A 1K7HA 3T02A 3A52A 3WAXA 1SHNA 4LR9A 2X98A 5LQQA 3T01A 1ED8A 5TJ3A 4MY4A 1KHNA 1AUKA 2W5TA 1N2KA 4LRDA 1ALIA 1EW9A 1Y6VA 2RH6A 3BDGB 3DPCA 5GRRA 4GTXA 3BDFA
chains in the Genus database with same CATH superfamily
4LR7A 3M8ZA 2IFYA 3T00A 1B8JA 1AJDA 5KXAA 4CXUA 4N7TA 4B56A 5C66A 3UN2A 3TG0A 4KAYA 1HDHA 1AJCA 3IGYB 4YR1A 5INHA 5IJSA 2W8SA 5EGEA 4LRCA 4UPKA 3NKPA 2GSOA 3WAVA 4UORA 2W5VA 1O98A 3UNYA 2XR9A 4GTYA 1HJKA 4UPLA 4UOPA 4LR2A 1ALJA 3SZYA 2IUCB 4LRAA 4CXKA 1ZEFA 1Y7AA 4NWXA 3BDGA 1EW2A 1O99A 2D1GA 5LRMA 1E1ZP 3WBHA 2GSNA 4LR8A 4KJGA 4ZG9A 5HRTA 1URBA 1ANIA 3NKRA 2GA3A 4CYSA 2XRGA 1EI6A 4TN0A 4KAVA 3Q3QA 1ZEDA 1FSUA 3WAYA 3M8WA 3IDDA 5IJQA 2QZUA 5LRNA 4GTWA 4LREA 2G9YA 4ZG7A 3ED4A 5DLVA 2ZKTA 1ALKA 3OT9A 4UPHA 5L0EA 2W5XA 2VQRA 1E33P 3KD8A 3M8YA 2W5SA 3NVLA 2IUCA 5EGHA 3UO0A 4CYRA 4UOOA 4ZGAA 4NWJA 5LIAA 4KM4A 3MK0A 4LRBA 1KHLA 4MHXA 1HQAA 3NKOA 5L0BA 5K4PA 4FDJA 4CXSA 3TX0A 1URAA 3B5QA 1KH7A 3M7VA 1ANJA 1E2SP 1EQJA 1ELXA 1P49A 3DYCA 1ELZA 3UN5A 2W5WA 1E3CP 2GSUA 2GLQA 3MK1A 1KHJA 2W8DA 1AJAA 2ANHA 3CMRA 3IGZB 1KH5A 3MK2A 4UPIA 5AJ9A 1N2LA 1KH4A 3E2DA 1SHQA 1AJBA 5DLTA 3WAWA 1EW8A 3NKQA 4GTZA 1ELYA 2W5QA 4LQYA 4MIVA 5L0KA 4KJDA 1KH9A 3TWZA 4FDIA 2W5RA 1ZEBA 5GOVA 1ED9A 1ALHA 3NKMA 4QAXA 3LXQA 4LRFA 3SZZA 5DLWA 1KHKA 3BDHA 3UN3A 1EJJA 3NKNA 4ZG6A 1K7HA 3T02A 3A52A 3WAXA 1SHNA 4LR9A 2X98A 5LQQA 3T01A 1ED8A 5TJ3A 4MY4A 1KHNA 1AUKA 2W5TA 1N2KA 4LRDA 1ALIA 1EW9A 1Y6VA 2RH6A 3BDGB 3DPCA 5GRRA 4GTXA 3BDFA
chains in the Genus database with same CATH topology
4LR7A 3M8ZA 2IFYA 3T00A 1B8JA 1AJDA 5KXAA 4CXUA 4N7TA 4B56A 5C66A 3UN2A 3TG0A 4KAYA 1HDHA 1AJCA 3IGYB 4YR1A 5INHA 5IJSA 2W8SA 5EGEA 4LRCA 4UPKA 3NKPA 2GSOA 3WAVA 4UORA 2W5VA 1O98A 3UNYA 2XR9A 4GTYA 1HJKA 4UPLA 4UOPA 4LR2A 1ALJA 3SZYA 2IUCB 4LRAA 4CXKA 1ZEFA 1Y7AA 4NWXA 3BDGA 1EW2A 1O99A 2D1GA 5LRMA 1E1ZP 3WBHA 2GSNA 4LR8A 4KJGA 4ZG9A 5HRTA 1URBA 1ANIA 3NKRA 2GA3A 4CYSA 2XRGA 1EI6A 4TN0A 4KAVA 3Q3QA 1ZEDA 1FSUA 3WAYA 3M8WA 3IDDA 5IJQA 2QZUA 5LRNA 4GTWA 4LREA 2G9YA 4ZG7A 3ED4A 5DLVA 2ZKTA 1ALKA 3OT9A 4UPHA 5L0EA 2W5XA 2VQRA 1E33P 3KD8A 3M8YA 2W5SA 3NVLA 2IUCA 5EGHA 3UO0A 4CYRA 4UOOA 4ZGAA 4NWJA 5LIAA 4KM4A 3MK0A 4LRBA 1KHLA 4MHXA 1HQAA 3NKOA 5L0BA 5K4PA 4FDJA 4CXSA 3TX0A 1URAA 3B5QA 1KH7A 3M7VA 1ANJA 1E2SP 1EQJA 1ELXA 1P49A 3DYCA 1ELZA 3UN5A 2W5WA 1E3CP 2GSUA 2GLQA 3MK1A 1KHJA 2W8DA 1AJAA 2ANHA 3CMRA 3IGZB 1KH5A 3MK2A 4UPIA 5AJ9A 1N2LA 1KH4A 3E2DA 1SHQA 1AJBA 5DLTA 3WAWA 1EW8A 3NKQA 4GTZA 1ELYA 2W5QA 4LQYA 4MIVA 5L0KA 4KJDA 1KH9A 3TWZA 4FDIA 2W5RA 1ZEBA 5GOVA 1ED9A 1ALHA 3NKMA 4QAXA 3LXQA 4LRFA 3SZZA 5DLWA 1KHKA 3BDHA 3UN3A 1EJJA 3NKNA 4ZG6A 1K7HA 3T02A 3A52A 3WAXA 1SHNA 4LR9A 2X98A 5LQQA 3T01A 1ED8A 5TJ3A 4MY4A 1KHNA 1AUKA 2W5TA 1N2KA 4LRDA 1ALIA 1EW9A 1Y6VA 2RH6A 3BDGB 3DPCA 5GRRA 4GTXA 3BDFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR7 A;  3M8Z A;  2IFY A;  3T00 A;  1B8J A;  1AJD A;  5KXA A;  4CXU A;  4N7T A;  4B56 A;  5C66 A;  3UN2 A;  3TG0 A;  4KAY A;  1HDH A;  1AJC A;  3IGY B;  4YR1 A;  5INH A;  5IJS A;  2W8S A;  5EGE A;  4LRC A;  4UPK A;  3NKP A;  2GSO A;  3WAV A;  4UOR A;  2W5V A;  1O98 A;  3UNY A;  2XR9 A;  4GTY A;  1HJK A;  4UPL A;  4UOP A;  4LR2 A;  1ALJ A;  3SZY A;  2IUC B;  4LRA A;  4CXK A;  1ZEF A;  1Y7A A;  4NWX A;  3BDG A;  1EW2 A;  1O99 A;  2D1G A;  5LRM A;  1E1Z P;  3WBH A;  2GSN A;  4LR8 A;  4KJG A;  4ZG9 A;  5HRT A;  1URB A;  1ANI A;  3NKR A;  2GA3 A;  4CYS A;  2XRG A;  1EI6 A;  4TN0 A;  4KAV A;  3Q3Q A;  1ZED A;  1FSU A;  3WAY A;  3M8W A;  3IDD A;  5IJQ A;  2QZU A;  5LRN A;  4GTW A;  4LRE A;  2G9Y A;  4ZG7 A;  3ED4 A;  5DLV A;  2ZKT A;  1ALK A;  3OT9 A;  4UPH A;  5L0E A;  2W5X A;  2VQR A;  1E33 P;  3KD8 A;  3M8Y A;  2W5S A;  3NVL A;  2IUC A;  5EGH A;  3UO0 A;  4CYR A;  4UOO A;  4ZGA A;  4NWJ A;  5LIA A;  4KM4 A;  3MK0 A;  4LRB A;  1KHL A;  4MHX A;  1HQA A;  3NKO A;  5L0B A;  5K4P A;  4FDJ A;  4CXS A;  3TX0 A;  1URA A;  3B5Q A;  1KH7 A;  3M7V A;  1ANJ A;  1E2S P;  1EQJ A;  1ELX A;  1P49 A;  3DYC A;  1ELZ A;  3UN5 A;  2W5W A;  1E3C P;  2GSU A;  2GLQ A;  3MK1 A;  1KHJ A;  2W8D A;  1AJA A;  2ANH A;  3CMR A;  3IGZ B;  1KH5 A;  3MK2 A;  4UPI A;  5AJ9 A;  1N2L A;  1KH4 A;  3E2D A;  1SHQ A;  1AJB A;  5DLT A;  3WAW A;  1EW8 A;  3NKQ A;  4GTZ A;  1ELY A;  2W5Q A;  4LQY A;  4MIV A;  5L0K A;  4KJD A;  1KH9 A;  3TWZ A;  4FDI A;  2W5R A;  1ZEB A;  5GOV A;  1ED9 A;  1ALH A;  3NKM A;  4QAX A;  3LXQ A;  4LRF A;  3SZZ A;  5DLW A;  1KHK A;  3BDH A;  3UN3 A;  1EJJ A;  3NKN A;  4ZG6 A;  1K7H A;  3T02 A;  3A52 A;  3WAX A;  1SHN A;  4LR9 A;  2X98 A;  5LQQ A;  3T01 A;  1ED8 A;  5TJ3 A;  4MY4 A;  1KHN A;  1AUK A;  2W5T A;  1N2K A;  4LRD A;  1ALI A;  1EW9 A;  1Y6V A;  2RH6 A;  3BDG B;  3DPC A;  5GRR A;  4GTX A;  3BDF A; 
#chains in the Genus database with same CATH topology
 4LR7 A;  3M8Z A;  2IFY A;  3T00 A;  1B8J A;  1AJD A;  5KXA A;  4CXU A;  4N7T A;  4B56 A;  5C66 A;  3UN2 A;  3TG0 A;  4KAY A;  1HDH A;  1AJC A;  3IGY B;  4YR1 A;  5INH A;  5IJS A;  2W8S A;  5EGE A;  4LRC A;  4UPK A;  3NKP A;  2GSO A;  3WAV A;  4UOR A;  2W5V A;  1O98 A;  3UNY A;  2XR9 A;  4GTY A;  1HJK A;  4UPL A;  4UOP A;  4LR2 A;  1ALJ A;  3SZY A;  2IUC B;  4LRA A;  4CXK A;  1ZEF A;  1Y7A A;  4NWX A;  3BDG A;  1EW2 A;  1O99 A;  2D1G A;  5LRM A;  1E1Z P;  3WBH A;  2GSN A;  4LR8 A;  4KJG A;  4ZG9 A;  5HRT A;  1URB A;  1ANI A;  3NKR A;  2GA3 A;  4CYS A;  2XRG A;  1EI6 A;  4TN0 A;  4KAV A;  3Q3Q A;  1ZED A;  1FSU A;  3WAY A;  3M8W A;  3IDD A;  5IJQ A;  2QZU A;  5LRN A;  4GTW A;  4LRE A;  2G9Y A;  4ZG7 A;  3ED4 A;  5DLV A;  2ZKT A;  1ALK A;  3OT9 A;  4UPH A;  5L0E A;  2W5X A;  2VQR A;  1E33 P;  3KD8 A;  3M8Y A;  2W5S A;  3NVL A;  2IUC A;  5EGH A;  3UO0 A;  4CYR A;  4UOO A;  4ZGA A;  4NWJ A;  5LIA A;  4KM4 A;  3MK0 A;  4LRB A;  1KHL A;  4MHX A;  1HQA A;  3NKO A;  5L0B A;  5K4P A;  4FDJ A;  4CXS A;  3TX0 A;  1URA A;  3B5Q A;  1KH7 A;  3M7V A;  1ANJ A;  1E2S P;  1EQJ A;  1ELX A;  1P49 A;  3DYC A;  1ELZ A;  3UN5 A;  2W5W A;  1E3C P;  2GSU A;  2GLQ A;  3MK1 A;  1KHJ A;  2W8D A;  1AJA A;  2ANH A;  3CMR A;  3IGZ B;  1KH5 A;  3MK2 A;  4UPI A;  5AJ9 A;  1N2L A;  1KH4 A;  3E2D A;  1SHQ A;  1AJB A;  5DLT A;  3WAW A;  1EW8 A;  3NKQ A;  4GTZ A;  1ELY A;  2W5Q A;  4LQY A;  4MIV A;  5L0K A;  4KJD A;  1KH9 A;  3TWZ A;  4FDI A;  2W5R A;  1ZEB A;  5GOV A;  1ED9 A;  1ALH A;  3NKM A;  4QAX A;  3LXQ A;  4LRF A;  3SZZ A;  5DLW A;  1KHK A;  3BDH A;  3UN3 A;  1EJJ A;  3NKN A;  4ZG6 A;  1K7H A;  3T02 A;  3A52 A;  3WAX A;  1SHN A;  4LR9 A;  2X98 A;  5LQQ A;  3T01 A;  1ED8 A;  5TJ3 A;  4MY4 A;  1KHN A;  1AUK A;  2W5T A;  1N2K A;  4LRD A;  1ALI A;  1EW9 A;  1Y6V A;  2RH6 A;  3BDG B;  3DPC A;  5GRR A;  4GTX A;  3BDF A; 
#chains in the Genus database with same CATH homology
 4LR7 A;  3M8Z A;  2IFY A;  3T00 A;  1B8J A;  1AJD A;  5KXA A;  4CXU A;  4N7T A;  4B56 A;  5C66 A;  3UN2 A;  3TG0 A;  4KAY A;  1HDH A;  1AJC A;  3IGY B;  4YR1 A;  5INH A;  5IJS A;  2W8S A;  5EGE A;  4LRC A;  4UPK A;  3NKP A;  2GSO A;  3WAV A;  4UOR A;  2W5V A;  1O98 A;  3UNY A;  2XR9 A;  4GTY A;  1HJK A;  4UPL A;  4UOP A;  4LR2 A;  1ALJ A;  3SZY A;  2IUC B;  4LRA A;  4CXK A;  1ZEF A;  1Y7A A;  4NWX A;  3BDG A;  1EW2 A;  1O99 A;  2D1G A;  5LRM A;  1E1Z P;  3WBH A;  2GSN A;  4LR8 A;  4KJG A;  4ZG9 A;  5HRT A;  1URB A;  1ANI A;  3NKR A;  2GA3 A;  4CYS A;  2XRG A;  1EI6 A;  4TN0 A;  4KAV A;  3Q3Q A;  1ZED A;  1FSU A;  3WAY A;  3M8W A;  3IDD A;  5IJQ A;  2QZU A;  5LRN A;  4GTW A;  4LRE A;  2G9Y A;  4ZG7 A;  3ED4 A;  5DLV A;  2ZKT A;  1ALK A;  3OT9 A;  4UPH A;  5L0E A;  2W5X A;  2VQR A;  1E33 P;  3KD8 A;  3M8Y A;  2W5S A;  3NVL A;  2IUC A;  5EGH A;  3UO0 A;  4CYR A;  4UOO A;  4ZGA A;  4NWJ A;  5LIA A;  4KM4 A;  3MK0 A;  4LRB A;  1KHL A;  4MHX A;  1HQA A;  3NKO A;  5L0B A;  5K4P A;  4FDJ A;  4CXS A;  3TX0 A;  1URA A;  3B5Q A;  1KH7 A;  3M7V A;  1ANJ A;  1E2S P;  1EQJ A;  1ELX A;  1P49 A;  3DYC A;  1ELZ A;  3UN5 A;  2W5W A;  1E3C P;  2GSU A;  2GLQ A;  3MK1 A;  1KHJ A;  2W8D A;  1AJA A;  2ANH A;  3CMR A;  3IGZ B;  1KH5 A;  3MK2 A;  4UPI A;  5AJ9 A;  1N2L A;  1KH4 A;  3E2D A;  1SHQ A;  1AJB A;  5DLT A;  3WAW A;  1EW8 A;  3NKQ A;  4GTZ A;  1ELY A;  2W5Q A;  4LQY A;  4MIV A;  5L0K A;  4KJD A;  1KH9 A;  3TWZ A;  4FDI A;  2W5R A;  1ZEB A;  5GOV A;  1ED9 A;  1ALH A;  3NKM A;  4QAX A;  3LXQ A;  4LRF A;  3SZZ A;  5DLW A;  1KHK A;  3BDH A;  3UN3 A;  1EJJ A;  3NKN A;  4ZG6 A;  1K7H A;  3T02 A;  3A52 A;  3WAX A;  1SHN A;  4LR9 A;  2X98 A;  5LQQ A;  3T01 A;  1ED8 A;  5TJ3 A;  4MY4 A;  1KHN A;  1AUK A;  2W5T A;  1N2K A;  4LRD A;  1ALI A;  1EW9 A;  1Y6V A;  2RH6 A;  3BDG B;  3DPC A;  5GRR A;  4GTX A;  3BDF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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