1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
1O99A 2X98A 5EGHA 5DLTA 1KHLA 4KAVA 1ELZA 4MHXA 3MK1A 5C66A 4LRFA 4CYSA 4KAYA 4CXKA 1ZEFA 3SZZA 4LRBA 1Y6VA 1N2LA 2W5QA 1KH5A 4ZG9A 4LRAA 4UORA 3TG0A 3IGZB 4LR9A 4UOPA 2W5SA 3B5QA 3UNYA 2ZKTA 3NKNA 1B8JA 2ANHA 1ELYA 5L0KA 2W5XA 1KH4A 5EGEA 1ZEDA 2IUCB 3Q3QA 1EI6A 1EW2A 3TWZA 5LIAA 1AJDA 2GLQA 2IFYA 5L0BA 4LQYA 4CYRA 3M8ZA 3CMRA 3A52A 4CXUA 3T01A 5IJSA 5L0EA 3DPCA 1KHKA 5K4PA 4CXSA 1K7HA 3LXQA 2W5WA 3E2DA 3BDFA 4NWXA 3TX0A 3BDHA 4TN0A 2W5RA 5LQQA 3UN5A 3BDGB 3MK0A 3WAYA 4UPIA 1E33P 1AJAA 1ANJA 1HDHA 2GSNA 2W8SA 3BDGA 3MK2A 1AJCA 2XRGA 5INHA 3UN3A 1O98A 2QZUA 4YR1A 1KH9A 3M7VA 4ZG6A 3M8WA 3DYCA 5GRRA 4QAXA 1E2SP 1EW9A 1P49A 4UPHA 3NVLA 3WAXA 1ALJA 5TJ3A 3ED4A 1KHJA 1AJBA 2GA3A 4ZG7A 4B56A 2W8DA 3WBHA 4ZGAA 3OT9A 3NKPA 4KJDA 1ALIA 4FDJA 3UO0A 1EQJA 4FDIA 5HRTA 3IGYB 3IDDA 3NKOA 1HQAA 5IJQA 4GTWA 1EW8A 4KJGA 1HJKA 4LR8A 3T02A 4LREA 4N7TA 5DLVA 1FSUA 1SHQA 1EJJA 1KHNA 2RH6A 3NKMA 3UN2A 5AJ9A 5KXAA 2GSOA 5DLWA 5LRMA 4LR2A 4LR7A 4NWJA 2XR9A 1N2KA 2VQRA 2GSUA 1URAA 1ALKA 4GTZA 4LRDA 4LRCA 2D1GA 1ED8A 4MIVA 3WAWA 2G9YA 1ALHA 1ELXA 1KH7A 4UPLA 2W5VA 3SZYA 1ANIA 3M8YA 3NKRA 2W5TA 1AUKA 1ED9A 1E3CP 3NKQA 1URBA 1Y7AA 1ZEBA 4KM4A 4UPKA 1SHNA 5GOVA 4GTXA 3WAVA 3KD8A 3T00A 4MY4A 5LRNA 1E1ZP 4UOOA 2IUCA 4GTYA
chains in the Genus database with same CATH superfamily
1O99A 2X98A 5EGHA 5DLTA 1KHLA 4KAVA 1ELZA 4MHXA 3MK1A 5C66A 4LRFA 4CYSA 4KAYA 4CXKA 1ZEFA 3SZZA 4LRBA 1Y6VA 1N2LA 2W5QA 1KH5A 4ZG9A 4LRAA 4UORA 3TG0A 3IGZB 4LR9A 4UOPA 2W5SA 3B5QA 3UNYA 2ZKTA 3NKNA 1B8JA 2ANHA 1ELYA 5L0KA 2W5XA 1KH4A 5EGEA 1ZEDA 2IUCB 3Q3QA 1EI6A 1EW2A 3TWZA 5LIAA 1AJDA 2GLQA 2IFYA 5L0BA 4LQYA 4CYRA 3M8ZA 3CMRA 3A52A 4CXUA 3T01A 5IJSA 5L0EA 3DPCA 1KHKA 5K4PA 4CXSA 1K7HA 3LXQA 2W5WA 3E2DA 3BDFA 4NWXA 3TX0A 3BDHA 4TN0A 2W5RA 5LQQA 3UN5A 3BDGB 3MK0A 3WAYA 4UPIA 1E33P 1AJAA 1ANJA 1HDHA 2GSNA 2W8SA 3BDGA 3MK2A 1AJCA 2XRGA 5INHA 3UN3A 1O98A 2QZUA 4YR1A 1KH9A 3M7VA 4ZG6A 3M8WA 3DYCA 5GRRA 4QAXA 1E2SP 1EW9A 1P49A 4UPHA 3NVLA 3WAXA 1ALJA 5TJ3A 3ED4A 1KHJA 1AJBA 2GA3A 4ZG7A 4B56A 2W8DA 3WBHA 4ZGAA 3OT9A 3NKPA 4KJDA 1ALIA 4FDJA 3UO0A 1EQJA 4FDIA 5HRTA 3IGYB 3IDDA 3NKOA 1HQAA 5IJQA 4GTWA 1EW8A 4KJGA 1HJKA 4LR8A 3T02A 4LREA 4N7TA 5DLVA 1FSUA 1SHQA 1EJJA 1KHNA 2RH6A 3NKMA 3UN2A 5AJ9A 5KXAA 2GSOA 5DLWA 5LRMA 4LR2A 4LR7A 4NWJA 2XR9A 1N2KA 2VQRA 2GSUA 1URAA 1ALKA 4GTZA 4LRDA 4LRCA 2D1GA 1ED8A 4MIVA 3WAWA 2G9YA 1ALHA 1ELXA 1KH7A 4UPLA 2W5VA 3SZYA 1ANIA 3M8YA 3NKRA 2W5TA 1AUKA 1ED9A 1E3CP 3NKQA 1URBA 1Y7AA 1ZEBA 4KM4A 4UPKA 1SHNA 5GOVA 4GTXA 3WAVA 3KD8A 3T00A 4MY4A 5LRNA 1E1ZP 4UOOA 2IUCA 4GTYA
chains in the Genus database with same CATH topology
1O99A 2X98A 5EGHA 5DLTA 1KHLA 4KAVA 1ELZA 4MHXA 3MK1A 5C66A 4LRFA 4CYSA 4KAYA 4CXKA 1ZEFA 3SZZA 4LRBA 1Y6VA 1N2LA 2W5QA 1KH5A 4ZG9A 4LRAA 4UORA 3TG0A 3IGZB 4LR9A 4UOPA 2W5SA 3B5QA 3UNYA 2ZKTA 3NKNA 1B8JA 2ANHA 1ELYA 5L0KA 2W5XA 1KH4A 5EGEA 1ZEDA 2IUCB 3Q3QA 1EI6A 1EW2A 3TWZA 5LIAA 1AJDA 2GLQA 2IFYA 5L0BA 4LQYA 4CYRA 3M8ZA 3CMRA 3A52A 4CXUA 3T01A 5IJSA 5L0EA 3DPCA 1KHKA 5K4PA 4CXSA 1K7HA 3LXQA 2W5WA 3E2DA 3BDFA 4NWXA 3TX0A 3BDHA 4TN0A 2W5RA 5LQQA 3UN5A 3BDGB 3MK0A 3WAYA 4UPIA 1E33P 1AJAA 1ANJA 1HDHA 2GSNA 2W8SA 3BDGA 3MK2A 1AJCA 2XRGA 5INHA 3UN3A 1O98A 2QZUA 4YR1A 1KH9A 3M7VA 4ZG6A 3M8WA 3DYCA 5GRRA 4QAXA 1E2SP 1EW9A 1P49A 4UPHA 3NVLA 3WAXA 1ALJA 5TJ3A 3ED4A 1KHJA 1AJBA 2GA3A 4ZG7A 4B56A 2W8DA 3WBHA 4ZGAA 3OT9A 3NKPA 4KJDA 1ALIA 4FDJA 3UO0A 1EQJA 4FDIA 5HRTA 3IGYB 3IDDA 3NKOA 1HQAA 5IJQA 4GTWA 1EW8A 4KJGA 1HJKA 4LR8A 3T02A 4LREA 4N7TA 5DLVA 1FSUA 1SHQA 1EJJA 1KHNA 2RH6A 3NKMA 3UN2A 5AJ9A 5KXAA 2GSOA 5DLWA 5LRMA 4LR2A 4LR7A 4NWJA 2XR9A 1N2KA 2VQRA 2GSUA 1URAA 1ALKA 4GTZA 4LRDA 4LRCA 2D1GA 1ED8A 4MIVA 3WAWA 2G9YA 1ALHA 1ELXA 1KH7A 4UPLA 2W5VA 3SZYA 1ANIA 3M8YA 3NKRA 2W5TA 1AUKA 1ED9A 1E3CP 3NKQA 1URBA 1Y7AA 1ZEBA 4KM4A 4UPKA 1SHNA 5GOVA 4GTXA 3WAVA 3KD8A 3T00A 4MY4A 5LRNA 1E1ZP 4UOOA 2IUCA 4GTYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O99 A;  2X98 A;  5EGH A;  5DLT A;  1KHL A;  4KAV A;  1ELZ A;  4MHX A;  3MK1 A;  5C66 A;  4LRF A;  4CYS A;  4KAY A;  4CXK A;  1ZEF A;  3SZZ A;  4LRB A;  1Y6V A;  1N2L A;  2W5Q A;  1KH5 A;  4ZG9 A;  4LRA A;  4UOR A;  3TG0 A;  3IGZ B;  4LR9 A;  4UOP A;  2W5S A;  3B5Q A;  3UNY A;  2ZKT A;  3NKN A;  1B8J A;  2ANH A;  1ELY A;  5L0K A;  2W5X A;  1KH4 A;  5EGE A;  1ZED A;  2IUC B;  3Q3Q A;  1EI6 A;  1EW2 A;  3TWZ A;  5LIA A;  1AJD A;  2GLQ A;  2IFY A;  5L0B A;  4LQY A;  4CYR A;  3M8Z A;  3CMR A;  3A52 A;  4CXU A;  3T01 A;  5IJS A;  5L0E A;  3DPC A;  1KHK A;  5K4P A;  4CXS A;  1K7H A;  3LXQ A;  2W5W A;  3E2D A;  3BDF A;  4NWX A;  3TX0 A;  3BDH A;  4TN0 A;  2W5R A;  5LQQ A;  3UN5 A;  3BDG B;  3MK0 A;  3WAY A;  4UPI A;  1E33 P;  1AJA A;  1ANJ A;  1HDH A;  2GSN A;  2W8S A;  3BDG A;  3MK2 A;  1AJC A;  2XRG A;  5INH A;  3UN3 A;  1O98 A;  2QZU A;  4YR1 A;  1KH9 A;  3M7V A;  4ZG6 A;  3M8W A;  3DYC A;  5GRR A;  4QAX A;  1E2S P;  1EW9 A;  1P49 A;  4UPH A;  3NVL A;  3WAX A;  1ALJ A;  5TJ3 A;  3ED4 A;  1KHJ A;  1AJB A;  2GA3 A;  4ZG7 A;  4B56 A;  2W8D A;  3WBH A;  4ZGA A;  3OT9 A;  3NKP A;  4KJD A;  1ALI A;  4FDJ A;  3UO0 A;  1EQJ A;  4FDI A;  5HRT A;  3IGY B;  3IDD A;  3NKO A;  1HQA A;  5IJQ A;  4GTW A;  1EW8 A;  4KJG A;  1HJK A;  4LR8 A;  3T02 A;  4LRE A;  4N7T A;  5DLV A;  1FSU A;  1SHQ A;  1EJJ A;  1KHN A;  2RH6 A;  3NKM A;  3UN2 A;  5AJ9 A;  5KXA A;  2GSO A;  5DLW A;  5LRM A;  4LR2 A;  4LR7 A;  4NWJ A;  2XR9 A;  1N2K A;  2VQR A;  2GSU A;  1URA A;  1ALK A;  4GTZ A;  4LRD A;  4LRC A;  2D1G A;  1ED8 A;  4MIV A;  3WAW A;  2G9Y A;  1ALH A;  1ELX A;  1KH7 A;  4UPL A;  2W5V A;  3SZY A;  1ANI A;  3M8Y A;  3NKR A;  2W5T A;  1AUK A;  1ED9 A;  1E3C P;  3NKQ A;  1URB A;  1Y7A A;  1ZEB A;  4KM4 A;  4UPK A;  1SHN A;  5GOV A;  4GTX A;  3WAV A;  3KD8 A;  3T00 A;  4MY4 A;  5LRN A;  1E1Z P;  4UOO A;  2IUC A;  4GTY A; 
#chains in the Genus database with same CATH topology
 1O99 A;  2X98 A;  5EGH A;  5DLT A;  1KHL A;  4KAV A;  1ELZ A;  4MHX A;  3MK1 A;  5C66 A;  4LRF A;  4CYS A;  4KAY A;  4CXK A;  1ZEF A;  3SZZ A;  4LRB A;  1Y6V A;  1N2L A;  2W5Q A;  1KH5 A;  4ZG9 A;  4LRA A;  4UOR A;  3TG0 A;  3IGZ B;  4LR9 A;  4UOP A;  2W5S A;  3B5Q A;  3UNY A;  2ZKT A;  3NKN A;  1B8J A;  2ANH A;  1ELY A;  5L0K A;  2W5X A;  1KH4 A;  5EGE A;  1ZED A;  2IUC B;  3Q3Q A;  1EI6 A;  1EW2 A;  3TWZ A;  5LIA A;  1AJD A;  2GLQ A;  2IFY A;  5L0B A;  4LQY A;  4CYR A;  3M8Z A;  3CMR A;  3A52 A;  4CXU A;  3T01 A;  5IJS A;  5L0E A;  3DPC A;  1KHK A;  5K4P A;  4CXS A;  1K7H A;  3LXQ A;  2W5W A;  3E2D A;  3BDF A;  4NWX A;  3TX0 A;  3BDH A;  4TN0 A;  2W5R A;  5LQQ A;  3UN5 A;  3BDG B;  3MK0 A;  3WAY A;  4UPI A;  1E33 P;  1AJA A;  1ANJ A;  1HDH A;  2GSN A;  2W8S A;  3BDG A;  3MK2 A;  1AJC A;  2XRG A;  5INH A;  3UN3 A;  1O98 A;  2QZU A;  4YR1 A;  1KH9 A;  3M7V A;  4ZG6 A;  3M8W A;  3DYC A;  5GRR A;  4QAX A;  1E2S P;  1EW9 A;  1P49 A;  4UPH A;  3NVL A;  3WAX A;  1ALJ A;  5TJ3 A;  3ED4 A;  1KHJ A;  1AJB A;  2GA3 A;  4ZG7 A;  4B56 A;  2W8D A;  3WBH A;  4ZGA A;  3OT9 A;  3NKP A;  4KJD A;  1ALI A;  4FDJ A;  3UO0 A;  1EQJ A;  4FDI A;  5HRT A;  3IGY B;  3IDD A;  3NKO A;  1HQA A;  5IJQ A;  4GTW A;  1EW8 A;  4KJG A;  1HJK A;  4LR8 A;  3T02 A;  4LRE A;  4N7T A;  5DLV A;  1FSU A;  1SHQ A;  1EJJ A;  1KHN A;  2RH6 A;  3NKM A;  3UN2 A;  5AJ9 A;  5KXA A;  2GSO A;  5DLW A;  5LRM A;  4LR2 A;  4LR7 A;  4NWJ A;  2XR9 A;  1N2K A;  2VQR A;  2GSU A;  1URA A;  1ALK A;  4GTZ A;  4LRD A;  4LRC A;  2D1G A;  1ED8 A;  4MIV A;  3WAW A;  2G9Y A;  1ALH A;  1ELX A;  1KH7 A;  4UPL A;  2W5V A;  3SZY A;  1ANI A;  3M8Y A;  3NKR A;  2W5T A;  1AUK A;  1ED9 A;  1E3C P;  3NKQ A;  1URB A;  1Y7A A;  1ZEB A;  4KM4 A;  4UPK A;  1SHN A;  5GOV A;  4GTX A;  3WAV A;  3KD8 A;  3T00 A;  4MY4 A;  5LRN A;  1E1Z P;  4UOO A;  2IUC A;  4GTY A; 
#chains in the Genus database with same CATH homology
 1O99 A;  2X98 A;  5EGH A;  5DLT A;  1KHL A;  4KAV A;  1ELZ A;  4MHX A;  3MK1 A;  5C66 A;  4LRF A;  4CYS A;  4KAY A;  4CXK A;  1ZEF A;  3SZZ A;  4LRB A;  1Y6V A;  1N2L A;  2W5Q A;  1KH5 A;  4ZG9 A;  4LRA A;  4UOR A;  3TG0 A;  3IGZ B;  4LR9 A;  4UOP A;  2W5S A;  3B5Q A;  3UNY A;  2ZKT A;  3NKN A;  1B8J A;  2ANH A;  1ELY A;  5L0K A;  2W5X A;  1KH4 A;  5EGE A;  1ZED A;  2IUC B;  3Q3Q A;  1EI6 A;  1EW2 A;  3TWZ A;  5LIA A;  1AJD A;  2GLQ A;  2IFY A;  5L0B A;  4LQY A;  4CYR A;  3M8Z A;  3CMR A;  3A52 A;  4CXU A;  3T01 A;  5IJS A;  5L0E A;  3DPC A;  1KHK A;  5K4P A;  4CXS A;  1K7H A;  3LXQ A;  2W5W A;  3E2D A;  3BDF A;  4NWX A;  3TX0 A;  3BDH A;  4TN0 A;  2W5R A;  5LQQ A;  3UN5 A;  3BDG B;  3MK0 A;  3WAY A;  4UPI A;  1E33 P;  1AJA A;  1ANJ A;  1HDH A;  2GSN A;  2W8S A;  3BDG A;  3MK2 A;  1AJC A;  2XRG A;  5INH A;  3UN3 A;  1O98 A;  2QZU A;  4YR1 A;  1KH9 A;  3M7V A;  4ZG6 A;  3M8W A;  3DYC A;  5GRR A;  4QAX A;  1E2S P;  1EW9 A;  1P49 A;  4UPH A;  3NVL A;  3WAX A;  1ALJ A;  5TJ3 A;  3ED4 A;  1KHJ A;  1AJB A;  2GA3 A;  4ZG7 A;  4B56 A;  2W8D A;  3WBH A;  4ZGA A;  3OT9 A;  3NKP A;  4KJD A;  1ALI A;  4FDJ A;  3UO0 A;  1EQJ A;  4FDI A;  5HRT A;  3IGY B;  3IDD A;  3NKO A;  1HQA A;  5IJQ A;  4GTW A;  1EW8 A;  4KJG A;  1HJK A;  4LR8 A;  3T02 A;  4LRE A;  4N7T A;  5DLV A;  1FSU A;  1SHQ A;  1EJJ A;  1KHN A;  2RH6 A;  3NKM A;  3UN2 A;  5AJ9 A;  5KXA A;  2GSO A;  5DLW A;  5LRM A;  4LR2 A;  4LR7 A;  4NWJ A;  2XR9 A;  1N2K A;  2VQR A;  2GSU A;  1URA A;  1ALK A;  4GTZ A;  4LRD A;  4LRC A;  2D1G A;  1ED8 A;  4MIV A;  3WAW A;  2G9Y A;  1ALH A;  1ELX A;  1KH7 A;  4UPL A;  2W5V A;  3SZY A;  1ANI A;  3M8Y A;  3NKR A;  2W5T A;  1AUK A;  1ED9 A;  1E3C P;  3NKQ A;  1URB A;  1Y7A A;  1ZEB A;  4KM4 A;  4UPK A;  1SHN A;  5GOV A;  4GTX A;  3WAV A;  3KD8 A;  3T00 A;  4MY4 A;  5LRN A;  1E1Z P;  4UOO A;  2IUC A;  4GTY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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