1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
1Y7AA 3BDFA 1AJAA 4UOOA 4MIVA 3NKMA 5EGEA 5INHA 2W8SA 4B56A 1EI6A 1KHNA 4UPIA 1B8JA 3UNYA 3A52A 4LRBA 4UPHA 2GSNA 4UOPA 4CYSA 1SHNA 4KAYA 4ZG7A 4LR9A 4LR2A 4CXUA 3E2DA 4CXSA 3BDGB 3SZZA 5L0EA 1AJBA 1K7HA 4LR8A 2IFYA 5DLVA 1O98A 3M8ZA 3NKRA 4LRFA 2GA3A 3IGZB 5LIAA 5L0KA 4QAXA 1EW2A 1EW8A 4TN0A 3WAWA 4LRDA 2W5RA 3BDHA 1P49A 3M8WA 2W5WA 1O99A 4LREA 2QZUA 3T02A 2XR9A 5LRNA 1ALHA 4UPLA 1HJKA 2W5XA 1EQJA 4GTXA 3TG0A 3MK1A 1KHJA 1Y6VA 3WBHA 4UORA 4MHXA 2W5QA 3DYCA 3NVLA 3IDDA 2GSUA 3BDGA 4NWXA 1ELYA 1ANIA 4YR1A 1E33P 2IUCB 5IJSA 2G9YA 2XRGA 4LQYA 1ALJA 4FDJA 5K4PA 1KH7A 2RH6A 3DPCA 2ANHA 5AJ9A 3T00A 1ZEBA 1KH4A 1KHLA 5IJQA 3UN2A 1ELZA 1E2SP 3UO0A 1ALKA 1HDHA 5TJ3A 3NKNA 3CMRA 5GOVA 3M7VA 1ED9A 5DLWA 3WAYA 3WAXA 5DLTA 1ALIA 1AJCA 2W8DA 1KHKA 1KH5A 3OT9A 5EGHA 3LXQA 4CXKA 1N2KA 1EJJA 1HQAA 5LRMA 3Q3QA 2ZKTA 5C66A 4ZGAA 1URAA 3IGYB 1N2LA 4ZG6A 3M8YA 4N7TA 5HRTA 3NKQA 5KXAA 4GTYA 3TX0A 5L0BA 3NKOA 2X98A 1ZEFA 1ANJA 5LQQA 4FDIA 3TWZA 3NKPA 3ED4A 4KAVA 2W5SA 2IUCA 4KM4A 3KD8A 3T01A 1ELXA 4KJGA 1FSUA 3UN3A 1AUKA 4UPKA 3UN5A 3MK2A 2GSOA 3MK0A 1EW9A 3WAVA 1SHQA 4LRCA 1E3CP 2VQRA 2W5VA 1KH9A 2W5TA 4CYRA 1ED8A 4ZG9A 2GLQA 4GTZA 4KJDA 4GTWA 1E1ZP 1URBA 4LR7A 3SZYA 5GRRA 1AJDA 1ZEDA 3B5QA 2D1GA 4MY4A 4LRAA 4NWJA
chains in the Genus database with same CATH superfamily
1Y7AA 3BDFA 1AJAA 4UOOA 4MIVA 3NKMA 5EGEA 5INHA 2W8SA 4B56A 1EI6A 1KHNA 4UPIA 1B8JA 3UNYA 3A52A 4LRBA 4UPHA 2GSNA 4UOPA 4CYSA 1SHNA 4KAYA 4ZG7A 4LR9A 4LR2A 4CXUA 3E2DA 4CXSA 3BDGB 3SZZA 5L0EA 1AJBA 1K7HA 4LR8A 2IFYA 5DLVA 1O98A 3M8ZA 3NKRA 4LRFA 2GA3A 3IGZB 5LIAA 5L0KA 4QAXA 1EW2A 1EW8A 4TN0A 3WAWA 4LRDA 2W5RA 3BDHA 1P49A 3M8WA 2W5WA 1O99A 4LREA 2QZUA 3T02A 2XR9A 5LRNA 1ALHA 4UPLA 1HJKA 2W5XA 1EQJA 4GTXA 3TG0A 3MK1A 1KHJA 1Y6VA 3WBHA 4UORA 4MHXA 2W5QA 3DYCA 3NVLA 3IDDA 2GSUA 3BDGA 4NWXA 1ELYA 1ANIA 4YR1A 1E33P 2IUCB 5IJSA 2G9YA 2XRGA 4LQYA 1ALJA 4FDJA 5K4PA 1KH7A 2RH6A 3DPCA 2ANHA 5AJ9A 3T00A 1ZEBA 1KH4A 1KHLA 5IJQA 3UN2A 1ELZA 1E2SP 3UO0A 1ALKA 1HDHA 5TJ3A 3NKNA 3CMRA 5GOVA 3M7VA 1ED9A 5DLWA 3WAYA 3WAXA 5DLTA 1ALIA 1AJCA 2W8DA 1KHKA 1KH5A 3OT9A 5EGHA 3LXQA 4CXKA 1N2KA 1EJJA 1HQAA 5LRMA 3Q3QA 2ZKTA 5C66A 4ZGAA 1URAA 3IGYB 1N2LA 4ZG6A 3M8YA 4N7TA 5HRTA 3NKQA 5KXAA 4GTYA 3TX0A 5L0BA 3NKOA 2X98A 1ZEFA 1ANJA 5LQQA 4FDIA 3TWZA 3NKPA 3ED4A 4KAVA 2W5SA 2IUCA 4KM4A 3KD8A 3T01A 1ELXA 4KJGA 1FSUA 3UN3A 1AUKA 4UPKA 3UN5A 3MK2A 2GSOA 3MK0A 1EW9A 3WAVA 1SHQA 4LRCA 1E3CP 2VQRA 2W5VA 1KH9A 2W5TA 4CYRA 1ED8A 4ZG9A 2GLQA 4GTZA 4KJDA 4GTWA 1E1ZP 1URBA 4LR7A 3SZYA 5GRRA 1AJDA 1ZEDA 3B5QA 2D1GA 4MY4A 4LRAA 4NWJA
chains in the Genus database with same CATH topology
1Y7AA 3BDFA 1AJAA 4UOOA 4MIVA 3NKMA 5EGEA 5INHA 2W8SA 4B56A 1EI6A 1KHNA 4UPIA 1B8JA 3UNYA 3A52A 4LRBA 4UPHA 2GSNA 4UOPA 4CYSA 1SHNA 4KAYA 4ZG7A 4LR9A 4LR2A 4CXUA 3E2DA 4CXSA 3BDGB 3SZZA 5L0EA 1AJBA 1K7HA 4LR8A 2IFYA 5DLVA 1O98A 3M8ZA 3NKRA 4LRFA 2GA3A 3IGZB 5LIAA 5L0KA 4QAXA 1EW2A 1EW8A 4TN0A 3WAWA 4LRDA 2W5RA 3BDHA 1P49A 3M8WA 2W5WA 1O99A 4LREA 2QZUA 3T02A 2XR9A 5LRNA 1ALHA 4UPLA 1HJKA 2W5XA 1EQJA 4GTXA 3TG0A 3MK1A 1KHJA 1Y6VA 3WBHA 4UORA 4MHXA 2W5QA 3DYCA 3NVLA 3IDDA 2GSUA 3BDGA 4NWXA 1ELYA 1ANIA 4YR1A 1E33P 2IUCB 5IJSA 2G9YA 2XRGA 4LQYA 1ALJA 4FDJA 5K4PA 1KH7A 2RH6A 3DPCA 2ANHA 5AJ9A 3T00A 1ZEBA 1KH4A 1KHLA 5IJQA 3UN2A 1ELZA 1E2SP 3UO0A 1ALKA 1HDHA 5TJ3A 3NKNA 3CMRA 5GOVA 3M7VA 1ED9A 5DLWA 3WAYA 3WAXA 5DLTA 1ALIA 1AJCA 2W8DA 1KHKA 1KH5A 3OT9A 5EGHA 3LXQA 4CXKA 1N2KA 1EJJA 1HQAA 5LRMA 3Q3QA 2ZKTA 5C66A 4ZGAA 1URAA 3IGYB 1N2LA 4ZG6A 3M8YA 4N7TA 5HRTA 3NKQA 5KXAA 4GTYA 3TX0A 5L0BA 3NKOA 2X98A 1ZEFA 1ANJA 5LQQA 4FDIA 3TWZA 3NKPA 3ED4A 4KAVA 2W5SA 2IUCA 4KM4A 3KD8A 3T01A 1ELXA 4KJGA 1FSUA 3UN3A 1AUKA 4UPKA 3UN5A 3MK2A 2GSOA 3MK0A 1EW9A 3WAVA 1SHQA 4LRCA 1E3CP 2VQRA 2W5VA 1KH9A 2W5TA 4CYRA 1ED8A 4ZG9A 2GLQA 4GTZA 4KJDA 4GTWA 1E1ZP 1URBA 4LR7A 3SZYA 5GRRA 1AJDA 1ZEDA 3B5QA 2D1GA 4MY4A 4LRAA 4NWJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y7A A;  3BDF A;  1AJA A;  4UOO A;  4MIV A;  3NKM A;  5EGE A;  5INH A;  2W8S A;  4B56 A;  1EI6 A;  1KHN A;  4UPI A;  1B8J A;  3UNY A;  3A52 A;  4LRB A;  4UPH A;  2GSN A;  4UOP A;  4CYS A;  1SHN A;  4KAY A;  4ZG7 A;  4LR9 A;  4LR2 A;  4CXU A;  3E2D A;  4CXS A;  3BDG B;  3SZZ A;  5L0E A;  1AJB A;  1K7H A;  4LR8 A;  2IFY A;  5DLV A;  1O98 A;  3M8Z A;  3NKR A;  4LRF A;  2GA3 A;  3IGZ B;  5LIA A;  5L0K A;  4QAX A;  1EW2 A;  1EW8 A;  4TN0 A;  3WAW A;  4LRD A;  2W5R A;  3BDH A;  1P49 A;  3M8W A;  2W5W A;  1O99 A;  4LRE A;  2QZU A;  3T02 A;  2XR9 A;  5LRN A;  1ALH A;  4UPL A;  1HJK A;  2W5X A;  1EQJ A;  4GTX A;  3TG0 A;  3MK1 A;  1KHJ A;  1Y6V A;  3WBH A;  4UOR A;  4MHX A;  2W5Q A;  3DYC A;  3NVL A;  3IDD A;  2GSU A;  3BDG A;  4NWX A;  1ELY A;  1ANI A;  4YR1 A;  1E33 P;  2IUC B;  5IJS A;  2G9Y A;  2XRG A;  4LQY A;  1ALJ A;  4FDJ A;  5K4P A;  1KH7 A;  2RH6 A;  3DPC A;  2ANH A;  5AJ9 A;  3T00 A;  1ZEB A;  1KH4 A;  1KHL A;  5IJQ A;  3UN2 A;  1ELZ A;  1E2S P;  3UO0 A;  1ALK A;  1HDH A;  5TJ3 A;  3NKN A;  3CMR A;  5GOV A;  3M7V A;  1ED9 A;  5DLW A;  3WAY A;  3WAX A;  5DLT A;  1ALI A;  1AJC A;  2W8D A;  1KHK A;  1KH5 A;  3OT9 A;  5EGH A;  3LXQ A;  4CXK A;  1N2K A;  1EJJ A;  1HQA A;  5LRM A;  3Q3Q A;  2ZKT A;  5C66 A;  4ZGA A;  1URA A;  3IGY B;  1N2L A;  4ZG6 A;  3M8Y A;  4N7T A;  5HRT A;  3NKQ A;  5KXA A;  4GTY A;  3TX0 A;  5L0B A;  3NKO A;  2X98 A;  1ZEF A;  1ANJ A;  5LQQ A;  4FDI A;  3TWZ A;  3NKP A;  3ED4 A;  4KAV A;  2W5S A;  2IUC A;  4KM4 A;  3KD8 A;  3T01 A;  1ELX A;  4KJG A;  1FSU A;  3UN3 A;  1AUK A;  4UPK A;  3UN5 A;  3MK2 A;  2GSO A;  3MK0 A;  1EW9 A;  3WAV A;  1SHQ A;  4LRC A;  1E3C P;  2VQR A;  2W5V A;  1KH9 A;  2W5T A;  4CYR A;  1ED8 A;  4ZG9 A;  2GLQ A;  4GTZ A;  4KJD A;  4GTW A;  1E1Z P;  1URB A;  4LR7 A;  3SZY A;  5GRR A;  1AJD A;  1ZED A;  3B5Q A;  2D1G A;  4MY4 A;  4LRA A;  4NWJ A; 
#chains in the Genus database with same CATH topology
 1Y7A A;  3BDF A;  1AJA A;  4UOO A;  4MIV A;  3NKM A;  5EGE A;  5INH A;  2W8S A;  4B56 A;  1EI6 A;  1KHN A;  4UPI A;  1B8J A;  3UNY A;  3A52 A;  4LRB A;  4UPH A;  2GSN A;  4UOP A;  4CYS A;  1SHN A;  4KAY A;  4ZG7 A;  4LR9 A;  4LR2 A;  4CXU A;  3E2D A;  4CXS A;  3BDG B;  3SZZ A;  5L0E A;  1AJB A;  1K7H A;  4LR8 A;  2IFY A;  5DLV A;  1O98 A;  3M8Z A;  3NKR A;  4LRF A;  2GA3 A;  3IGZ B;  5LIA A;  5L0K A;  4QAX A;  1EW2 A;  1EW8 A;  4TN0 A;  3WAW A;  4LRD A;  2W5R A;  3BDH A;  1P49 A;  3M8W A;  2W5W A;  1O99 A;  4LRE A;  2QZU A;  3T02 A;  2XR9 A;  5LRN A;  1ALH A;  4UPL A;  1HJK A;  2W5X A;  1EQJ A;  4GTX A;  3TG0 A;  3MK1 A;  1KHJ A;  1Y6V A;  3WBH A;  4UOR A;  4MHX A;  2W5Q A;  3DYC A;  3NVL A;  3IDD A;  2GSU A;  3BDG A;  4NWX A;  1ELY A;  1ANI A;  4YR1 A;  1E33 P;  2IUC B;  5IJS A;  2G9Y A;  2XRG A;  4LQY A;  1ALJ A;  4FDJ A;  5K4P A;  1KH7 A;  2RH6 A;  3DPC A;  2ANH A;  5AJ9 A;  3T00 A;  1ZEB A;  1KH4 A;  1KHL A;  5IJQ A;  3UN2 A;  1ELZ A;  1E2S P;  3UO0 A;  1ALK A;  1HDH A;  5TJ3 A;  3NKN A;  3CMR A;  5GOV A;  3M7V A;  1ED9 A;  5DLW A;  3WAY A;  3WAX A;  5DLT A;  1ALI A;  1AJC A;  2W8D A;  1KHK A;  1KH5 A;  3OT9 A;  5EGH A;  3LXQ A;  4CXK A;  1N2K A;  1EJJ A;  1HQA A;  5LRM A;  3Q3Q A;  2ZKT A;  5C66 A;  4ZGA A;  1URA A;  3IGY B;  1N2L A;  4ZG6 A;  3M8Y A;  4N7T A;  5HRT A;  3NKQ A;  5KXA A;  4GTY A;  3TX0 A;  5L0B A;  3NKO A;  2X98 A;  1ZEF A;  1ANJ A;  5LQQ A;  4FDI A;  3TWZ A;  3NKP A;  3ED4 A;  4KAV A;  2W5S A;  2IUC A;  4KM4 A;  3KD8 A;  3T01 A;  1ELX A;  4KJG A;  1FSU A;  3UN3 A;  1AUK A;  4UPK A;  3UN5 A;  3MK2 A;  2GSO A;  3MK0 A;  1EW9 A;  3WAV A;  1SHQ A;  4LRC A;  1E3C P;  2VQR A;  2W5V A;  1KH9 A;  2W5T A;  4CYR A;  1ED8 A;  4ZG9 A;  2GLQ A;  4GTZ A;  4KJD A;  4GTW A;  1E1Z P;  1URB A;  4LR7 A;  3SZY A;  5GRR A;  1AJD A;  1ZED A;  3B5Q A;  2D1G A;  4MY4 A;  4LRA A;  4NWJ A; 
#chains in the Genus database with same CATH homology
 1Y7A A;  3BDF A;  1AJA A;  4UOO A;  4MIV A;  3NKM A;  5EGE A;  5INH A;  2W8S A;  4B56 A;  1EI6 A;  1KHN A;  4UPI A;  1B8J A;  3UNY A;  3A52 A;  4LRB A;  4UPH A;  2GSN A;  4UOP A;  4CYS A;  1SHN A;  4KAY A;  4ZG7 A;  4LR9 A;  4LR2 A;  4CXU A;  3E2D A;  4CXS A;  3BDG B;  3SZZ A;  5L0E A;  1AJB A;  1K7H A;  4LR8 A;  2IFY A;  5DLV A;  1O98 A;  3M8Z A;  3NKR A;  4LRF A;  2GA3 A;  3IGZ B;  5LIA A;  5L0K A;  4QAX A;  1EW2 A;  1EW8 A;  4TN0 A;  3WAW A;  4LRD A;  2W5R A;  3BDH A;  1P49 A;  3M8W A;  2W5W A;  1O99 A;  4LRE A;  2QZU A;  3T02 A;  2XR9 A;  5LRN A;  1ALH A;  4UPL A;  1HJK A;  2W5X A;  1EQJ A;  4GTX A;  3TG0 A;  3MK1 A;  1KHJ A;  1Y6V A;  3WBH A;  4UOR A;  4MHX A;  2W5Q A;  3DYC A;  3NVL A;  3IDD A;  2GSU A;  3BDG A;  4NWX A;  1ELY A;  1ANI A;  4YR1 A;  1E33 P;  2IUC B;  5IJS A;  2G9Y A;  2XRG A;  4LQY A;  1ALJ A;  4FDJ A;  5K4P A;  1KH7 A;  2RH6 A;  3DPC A;  2ANH A;  5AJ9 A;  3T00 A;  1ZEB A;  1KH4 A;  1KHL A;  5IJQ A;  3UN2 A;  1ELZ A;  1E2S P;  3UO0 A;  1ALK A;  1HDH A;  5TJ3 A;  3NKN A;  3CMR A;  5GOV A;  3M7V A;  1ED9 A;  5DLW A;  3WAY A;  3WAX A;  5DLT A;  1ALI A;  1AJC A;  2W8D A;  1KHK A;  1KH5 A;  3OT9 A;  5EGH A;  3LXQ A;  4CXK A;  1N2K A;  1EJJ A;  1HQA A;  5LRM A;  3Q3Q A;  2ZKT A;  5C66 A;  4ZGA A;  1URA A;  3IGY B;  1N2L A;  4ZG6 A;  3M8Y A;  4N7T A;  5HRT A;  3NKQ A;  5KXA A;  4GTY A;  3TX0 A;  5L0B A;  3NKO A;  2X98 A;  1ZEF A;  1ANJ A;  5LQQ A;  4FDI A;  3TWZ A;  3NKP A;  3ED4 A;  4KAV A;  2W5S A;  2IUC A;  4KM4 A;  3KD8 A;  3T01 A;  1ELX A;  4KJG A;  1FSU A;  3UN3 A;  1AUK A;  4UPK A;  3UN5 A;  3MK2 A;  2GSO A;  3MK0 A;  1EW9 A;  3WAV A;  1SHQ A;  4LRC A;  1E3C P;  2VQR A;  2W5V A;  1KH9 A;  2W5T A;  4CYR A;  1ED8 A;  4ZG9 A;  2GLQ A;  4GTZ A;  4KJD A;  4GTW A;  1E1Z P;  1URB A;  4LR7 A;  3SZY A;  5GRR A;  1AJD A;  1ZED A;  3B5Q A;  2D1G A;  4MY4 A;  4LRA A;  4NWJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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