1KHKA

E. coli alkaline phosphatase mutant (d153hd330n)
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 149
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khkA00
1EJJA 4MHXA 3WAXA 3UN5A 1HJKA 1ALIA 1HDHA 2IUCB 2W5SA 4LRBA 4ZG6A 1ANIA 3M7VA 4LRDA 4KJDA 3IGZB 4CYRA 3WAWA 1N2LA 3SZYA 1AJBA 1ELYA 1ELXA 1EQJA 1KHLA 4LR8A 2GA3A 3KD8A 4LREA 1Y7AA 1ED9A 1EW8A 3WAVA 1ELZA 3B5QA 3CMRA 5DLVA 5LIAA 3MK1A 5L0BA 3BDGB 3WAYA 3MK0A 4UPIA 3NKMA 5DLWA 1KH9A 2GSUA 3A52A 1P49A 1AUKA 2W5RA 4GTZA 1ZEFA 3Q3QA 3NKRA 3TG0A 4UPLA 4UOPA 1URBA 1O99A 1SHQA 4CYSA 1ALKA 1E2SP 4KM4A 1EI6A 5LRMA 1EW2A 2ZKTA 4GTWA 2W5WA 4NWXA 1ZEDA 5L0KA 2VQRA 3ED4A 4LR7A 3IGYB 3DPCA 3BDHA 5INHA 5IJSA 2X98A 3BDGA 3NKQA 3UO0A 4TN0A 1ED8A 1ZEBA 2W5XA 5GOVA 5HRTA 1E1ZP 2G9YA 3BDFA 3M8ZA 1KH7A 3M8YA 3NVLA 4FDJA 3UN3A 1EW9A 5K4PA 3TX0A 2IUCA 1E3CP 4LR9A 2IFYA 2GLQA 5EGHA 4UPHA 5L0EA 3WBHA 3UNYA 4FDIA 5LQQA 1URAA 4LRCA 2W5QA 4KJGA 4KAVA 2RH6A 1KHNA 1AJCA 3E2DA 5DLTA 4UOOA 1KH5A 4MY4A 5TJ3A 1Y6VA 5EGEA 4GTYA 4CXSA 4N7TA 4ZG9A 3T00A 4LQYA 3T02A 1HQAA 3MK2A 2W8SA 3M8WA 4NWJA 1SHNA 4QAXA 5LRNA 1N2KA 3NKPA 1B8JA 2QZUA 4CXUA 2XR9A 4KAYA 2ANHA 5GRRA 1ALJA 4LRFA 4CXKA 5KXAA 2D1GA 2W5TA 5AJ9A 4B56A 1ALHA 1KH4A 2W8DA 4MIVA 5IJQA 1AJAA 3NKNA 3UN2A 2GSOA 4ZG7A 1E33P 1K7HA 3DYCA 2XRGA 1AJDA 3SZZA 1KHKA 4GTXA 4UORA 2W5VA 2GSNA 5C66A 3TWZA 1KHJA 4YR1A 3LXQA 1ANJA 3IDDA 1O98A 4LR2A 4LRAA 3NKOA 1FSUA 3OT9A 4UPKA 3T01A 4ZGAA
chains in the Genus database with same CATH superfamily
1EJJA 4MHXA 3WAXA 3UN5A 1HJKA 1ALIA 1HDHA 2IUCB 2W5SA 4LRBA 4ZG6A 1ANIA 3M7VA 4LRDA 4KJDA 3IGZB 4CYRA 3WAWA 1N2LA 3SZYA 1AJBA 1ELYA 1ELXA 1EQJA 1KHLA 4LR8A 2GA3A 3KD8A 4LREA 1Y7AA 1ED9A 1EW8A 3WAVA 1ELZA 3B5QA 3CMRA 5DLVA 5LIAA 3MK1A 5L0BA 3BDGB 3WAYA 3MK0A 4UPIA 3NKMA 5DLWA 1KH9A 2GSUA 3A52A 1P49A 1AUKA 2W5RA 4GTZA 1ZEFA 3Q3QA 3NKRA 3TG0A 4UPLA 4UOPA 1URBA 1O99A 1SHQA 4CYSA 1ALKA 1E2SP 4KM4A 1EI6A 5LRMA 1EW2A 2ZKTA 4GTWA 2W5WA 4NWXA 1ZEDA 5L0KA 2VQRA 3ED4A 4LR7A 3IGYB 3DPCA 3BDHA 5INHA 5IJSA 2X98A 3BDGA 3NKQA 3UO0A 4TN0A 1ED8A 1ZEBA 2W5XA 5GOVA 5HRTA 1E1ZP 2G9YA 3BDFA 3M8ZA 1KH7A 3M8YA 3NVLA 4FDJA 3UN3A 1EW9A 5K4PA 3TX0A 2IUCA 1E3CP 4LR9A 2IFYA 2GLQA 5EGHA 4UPHA 5L0EA 3WBHA 3UNYA 4FDIA 5LQQA 1URAA 4LRCA 2W5QA 4KJGA 4KAVA 2RH6A 1KHNA 1AJCA 3E2DA 5DLTA 4UOOA 1KH5A 4MY4A 5TJ3A 1Y6VA 5EGEA 4GTYA 4CXSA 4N7TA 4ZG9A 3T00A 4LQYA 3T02A 1HQAA 3MK2A 2W8SA 3M8WA 4NWJA 1SHNA 4QAXA 5LRNA 1N2KA 3NKPA 1B8JA 2QZUA 4CXUA 2XR9A 4KAYA 2ANHA 5GRRA 1ALJA 4LRFA 4CXKA 5KXAA 2D1GA 2W5TA 5AJ9A 4B56A 1ALHA 1KH4A 2W8DA 4MIVA 5IJQA 1AJAA 3NKNA 3UN2A 2GSOA 4ZG7A 1E33P 1K7HA 3DYCA 2XRGA 1AJDA 3SZZA 1KHKA 4GTXA 4UORA 2W5VA 2GSNA 5C66A 3TWZA 1KHJA 4YR1A 3LXQA 1ANJA 3IDDA 1O98A 4LR2A 4LRAA 3NKOA 1FSUA 3OT9A 4UPKA 3T01A 4ZGAA
chains in the Genus database with same CATH topology
1EJJA 4MHXA 3WAXA 3UN5A 1HJKA 1ALIA 1HDHA 2IUCB 2W5SA 4LRBA 4ZG6A 1ANIA 3M7VA 4LRDA 4KJDA 3IGZB 4CYRA 3WAWA 1N2LA 3SZYA 1AJBA 1ELYA 1ELXA 1EQJA 1KHLA 4LR8A 2GA3A 3KD8A 4LREA 1Y7AA 1ED9A 1EW8A 3WAVA 1ELZA 3B5QA 3CMRA 5DLVA 5LIAA 3MK1A 5L0BA 3BDGB 3WAYA 3MK0A 4UPIA 3NKMA 5DLWA 1KH9A 2GSUA 3A52A 1P49A 1AUKA 2W5RA 4GTZA 1ZEFA 3Q3QA 3NKRA 3TG0A 4UPLA 4UOPA 1URBA 1O99A 1SHQA 4CYSA 1ALKA 1E2SP 4KM4A 1EI6A 5LRMA 1EW2A 2ZKTA 4GTWA 2W5WA 4NWXA 1ZEDA 5L0KA 2VQRA 3ED4A 4LR7A 3IGYB 3DPCA 3BDHA 5INHA 5IJSA 2X98A 3BDGA 3NKQA 3UO0A 4TN0A 1ED8A 1ZEBA 2W5XA 5GOVA 5HRTA 1E1ZP 2G9YA 3BDFA 3M8ZA 1KH7A 3M8YA 3NVLA 4FDJA 3UN3A 1EW9A 5K4PA 3TX0A 2IUCA 1E3CP 4LR9A 2IFYA 2GLQA 5EGHA 4UPHA 5L0EA 3WBHA 3UNYA 4FDIA 5LQQA 1URAA 4LRCA 2W5QA 4KJGA 4KAVA 2RH6A 1KHNA 1AJCA 3E2DA 5DLTA 4UOOA 1KH5A 4MY4A 5TJ3A 1Y6VA 5EGEA 4GTYA 4CXSA 4N7TA 4ZG9A 3T00A 4LQYA 3T02A 1HQAA 3MK2A 2W8SA 3M8WA 4NWJA 1SHNA 4QAXA 5LRNA 1N2KA 3NKPA 1B8JA 2QZUA 4CXUA 2XR9A 4KAYA 2ANHA 5GRRA 1ALJA 4LRFA 4CXKA 5KXAA 2D1GA 2W5TA 5AJ9A 4B56A 1ALHA 1KH4A 2W8DA 4MIVA 5IJQA 1AJAA 3NKNA 3UN2A 2GSOA 4ZG7A 1E33P 1K7HA 3DYCA 2XRGA 1AJDA 3SZZA 1KHKA 4GTXA 4UORA 2W5VA 2GSNA 5C66A 3TWZA 1KHJA 4YR1A 3LXQA 1ANJA 3IDDA 1O98A 4LR2A 4LRAA 3NKOA 1FSUA 3OT9A 4UPKA 3T01A 4ZGAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EJJ A;  4MHX A;  3WAX A;  3UN5 A;  1HJK A;  1ALI A;  1HDH A;  2IUC B;  2W5S A;  4LRB A;  4ZG6 A;  1ANI A;  3M7V A;  4LRD A;  4KJD A;  3IGZ B;  4CYR A;  3WAW A;  1N2L A;  3SZY A;  1AJB A;  1ELY A;  1ELX A;  1EQJ A;  1KHL A;  4LR8 A;  2GA3 A;  3KD8 A;  4LRE A;  1Y7A A;  1ED9 A;  1EW8 A;  3WAV A;  1ELZ A;  3B5Q A;  3CMR A;  5DLV A;  5LIA A;  3MK1 A;  5L0B A;  3BDG B;  3WAY A;  3MK0 A;  4UPI A;  3NKM A;  5DLW A;  1KH9 A;  2GSU A;  3A52 A;  1P49 A;  1AUK A;  2W5R A;  4GTZ A;  1ZEF A;  3Q3Q A;  3NKR A;  3TG0 A;  4UPL A;  4UOP A;  1URB A;  1O99 A;  1SHQ A;  4CYS A;  1ALK A;  1E2S P;  4KM4 A;  1EI6 A;  5LRM A;  1EW2 A;  2ZKT A;  4GTW A;  2W5W A;  4NWX A;  1ZED A;  5L0K A;  2VQR A;  3ED4 A;  4LR7 A;  3IGY B;  3DPC A;  3BDH A;  5INH A;  5IJS A;  2X98 A;  3BDG A;  3NKQ A;  3UO0 A;  4TN0 A;  1ED8 A;  1ZEB A;  2W5X A;  5GOV A;  5HRT A;  1E1Z P;  2G9Y A;  3BDF A;  3M8Z A;  1KH7 A;  3M8Y A;  3NVL A;  4FDJ A;  3UN3 A;  1EW9 A;  5K4P A;  3TX0 A;  2IUC A;  1E3C P;  4LR9 A;  2IFY A;  2GLQ A;  5EGH A;  4UPH A;  5L0E A;  3WBH A;  3UNY A;  4FDI A;  5LQQ A;  1URA A;  4LRC A;  2W5Q A;  4KJG A;  4KAV A;  2RH6 A;  1KHN A;  1AJC A;  3E2D A;  5DLT A;  4UOO A;  1KH5 A;  4MY4 A;  5TJ3 A;  1Y6V A;  5EGE A;  4GTY A;  4CXS A;  4N7T A;  4ZG9 A;  3T00 A;  4LQY A;  3T02 A;  1HQA A;  3MK2 A;  2W8S A;  3M8W A;  4NWJ A;  1SHN A;  4QAX A;  5LRN A;  1N2K A;  3NKP A;  1B8J A;  2QZU A;  4CXU A;  2XR9 A;  4KAY A;  2ANH A;  5GRR A;  1ALJ A;  4LRF A;  4CXK A;  5KXA A;  2D1G A;  2W5T A;  5AJ9 A;  4B56 A;  1ALH A;  1KH4 A;  2W8D A;  4MIV A;  5IJQ A;  1AJA A;  3NKN A;  3UN2 A;  2GSO A;  4ZG7 A;  1E33 P;  1K7H A;  3DYC A;  2XRG A;  1AJD A;  3SZZ A;  1KHK A;  4GTX A;  4UOR A;  2W5V A;  2GSN A;  5C66 A;  3TWZ A;  1KHJ A;  4YR1 A;  3LXQ A;  1ANJ A;  3IDD A;  1O98 A;  4LR2 A;  4LRA A;  3NKO A;  1FSU A;  3OT9 A;  4UPK A;  3T01 A;  4ZGA A; 
#chains in the Genus database with same CATH topology
 1EJJ A;  4MHX A;  3WAX A;  3UN5 A;  1HJK A;  1ALI A;  1HDH A;  2IUC B;  2W5S A;  4LRB A;  4ZG6 A;  1ANI A;  3M7V A;  4LRD A;  4KJD A;  3IGZ B;  4CYR A;  3WAW A;  1N2L A;  3SZY A;  1AJB A;  1ELY A;  1ELX A;  1EQJ A;  1KHL A;  4LR8 A;  2GA3 A;  3KD8 A;  4LRE A;  1Y7A A;  1ED9 A;  1EW8 A;  3WAV A;  1ELZ A;  3B5Q A;  3CMR A;  5DLV A;  5LIA A;  3MK1 A;  5L0B A;  3BDG B;  3WAY A;  3MK0 A;  4UPI A;  3NKM A;  5DLW A;  1KH9 A;  2GSU A;  3A52 A;  1P49 A;  1AUK A;  2W5R A;  4GTZ A;  1ZEF A;  3Q3Q A;  3NKR A;  3TG0 A;  4UPL A;  4UOP A;  1URB A;  1O99 A;  1SHQ A;  4CYS A;  1ALK A;  1E2S P;  4KM4 A;  1EI6 A;  5LRM A;  1EW2 A;  2ZKT A;  4GTW A;  2W5W A;  4NWX A;  1ZED A;  5L0K A;  2VQR A;  3ED4 A;  4LR7 A;  3IGY B;  3DPC A;  3BDH A;  5INH A;  5IJS A;  2X98 A;  3BDG A;  3NKQ A;  3UO0 A;  4TN0 A;  1ED8 A;  1ZEB A;  2W5X A;  5GOV A;  5HRT A;  1E1Z P;  2G9Y A;  3BDF A;  3M8Z A;  1KH7 A;  3M8Y A;  3NVL A;  4FDJ A;  3UN3 A;  1EW9 A;  5K4P A;  3TX0 A;  2IUC A;  1E3C P;  4LR9 A;  2IFY A;  2GLQ A;  5EGH A;  4UPH A;  5L0E A;  3WBH A;  3UNY A;  4FDI A;  5LQQ A;  1URA A;  4LRC A;  2W5Q A;  4KJG A;  4KAV A;  2RH6 A;  1KHN A;  1AJC A;  3E2D A;  5DLT A;  4UOO A;  1KH5 A;  4MY4 A;  5TJ3 A;  1Y6V A;  5EGE A;  4GTY A;  4CXS A;  4N7T A;  4ZG9 A;  3T00 A;  4LQY A;  3T02 A;  1HQA A;  3MK2 A;  2W8S A;  3M8W A;  4NWJ A;  1SHN A;  4QAX A;  5LRN A;  1N2K A;  3NKP A;  1B8J A;  2QZU A;  4CXU A;  2XR9 A;  4KAY A;  2ANH A;  5GRR A;  1ALJ A;  4LRF A;  4CXK A;  5KXA A;  2D1G A;  2W5T A;  5AJ9 A;  4B56 A;  1ALH A;  1KH4 A;  2W8D A;  4MIV A;  5IJQ A;  1AJA A;  3NKN A;  3UN2 A;  2GSO A;  4ZG7 A;  1E33 P;  1K7H A;  3DYC A;  2XRG A;  1AJD A;  3SZZ A;  1KHK A;  4GTX A;  4UOR A;  2W5V A;  2GSN A;  5C66 A;  3TWZ A;  1KHJ A;  4YR1 A;  3LXQ A;  1ANJ A;  3IDD A;  1O98 A;  4LR2 A;  4LRA A;  3NKO A;  1FSU A;  3OT9 A;  4UPK A;  3T01 A;  4ZGA A; 
#chains in the Genus database with same CATH homology
 1EJJ A;  4MHX A;  3WAX A;  3UN5 A;  1HJK A;  1ALI A;  1HDH A;  2IUC B;  2W5S A;  4LRB A;  4ZG6 A;  1ANI A;  3M7V A;  4LRD A;  4KJD A;  3IGZ B;  4CYR A;  3WAW A;  1N2L A;  3SZY A;  1AJB A;  1ELY A;  1ELX A;  1EQJ A;  1KHL A;  4LR8 A;  2GA3 A;  3KD8 A;  4LRE A;  1Y7A A;  1ED9 A;  1EW8 A;  3WAV A;  1ELZ A;  3B5Q A;  3CMR A;  5DLV A;  5LIA A;  3MK1 A;  5L0B A;  3BDG B;  3WAY A;  3MK0 A;  4UPI A;  3NKM A;  5DLW A;  1KH9 A;  2GSU A;  3A52 A;  1P49 A;  1AUK A;  2W5R A;  4GTZ A;  1ZEF A;  3Q3Q A;  3NKR A;  3TG0 A;  4UPL A;  4UOP A;  1URB A;  1O99 A;  1SHQ A;  4CYS A;  1ALK A;  1E2S P;  4KM4 A;  1EI6 A;  5LRM A;  1EW2 A;  2ZKT A;  4GTW A;  2W5W A;  4NWX A;  1ZED A;  5L0K A;  2VQR A;  3ED4 A;  4LR7 A;  3IGY B;  3DPC A;  3BDH A;  5INH A;  5IJS A;  2X98 A;  3BDG A;  3NKQ A;  3UO0 A;  4TN0 A;  1ED8 A;  1ZEB A;  2W5X A;  5GOV A;  5HRT A;  1E1Z P;  2G9Y A;  3BDF A;  3M8Z A;  1KH7 A;  3M8Y A;  3NVL A;  4FDJ A;  3UN3 A;  1EW9 A;  5K4P A;  3TX0 A;  2IUC A;  1E3C P;  4LR9 A;  2IFY A;  2GLQ A;  5EGH A;  4UPH A;  5L0E A;  3WBH A;  3UNY A;  4FDI A;  5LQQ A;  1URA A;  4LRC A;  2W5Q A;  4KJG A;  4KAV A;  2RH6 A;  1KHN A;  1AJC A;  3E2D A;  5DLT A;  4UOO A;  1KH5 A;  4MY4 A;  5TJ3 A;  1Y6V A;  5EGE A;  4GTY A;  4CXS A;  4N7T A;  4ZG9 A;  3T00 A;  4LQY A;  3T02 A;  1HQA A;  3MK2 A;  2W8S A;  3M8W A;  4NWJ A;  1SHN A;  4QAX A;  5LRN A;  1N2K A;  3NKP A;  1B8J A;  2QZU A;  4CXU A;  2XR9 A;  4KAY A;  2ANH A;  5GRR A;  1ALJ A;  4LRF A;  4CXK A;  5KXA A;  2D1G A;  2W5T A;  5AJ9 A;  4B56 A;  1ALH A;  1KH4 A;  2W8D A;  4MIV A;  5IJQ A;  1AJA A;  3NKN A;  3UN2 A;  2GSO A;  4ZG7 A;  1E33 P;  1K7H A;  3DYC A;  2XRG A;  1AJD A;  3SZZ A;  1KHK A;  4GTX A;  4UOR A;  2W5V A;  2GSN A;  5C66 A;  3TWZ A;  1KHJ A;  4YR1 A;  3LXQ A;  1ANJ A;  3IDD A;  1O98 A;  4LR2 A;  4LRA A;  3NKO A;  1FSU A;  3OT9 A;  4UPK A;  3T01 A;  4ZGA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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