4MIVA

Crystal structure of sulfamidase, crystal form l
Total Genus 169
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
169
Knots found
sequence length
484
structure length
483
Chain Sequence
PRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNELRSH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords N-sulphoglucosamine sulphohydrolase
total genus 169
structure length 483
sequence length 484
chains with identical sequence B, C, D, E, F, G, H
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.10.1.1: N-sulfoglucosamine sulfohydrolase.
pdb deposition date 2013-09-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
A PF16347 DUF4976 Domain of unknown function (DUF4976)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4mivA01
1N2KA 2IUCA 4NWXA 3SZZA 2G9YA 3UN3A 5GOVA 4CXSA 2W8DA 3BDGB 4FDIA 2W5QA 4LRDA 5KXAA 5IJQA 3DYCA 3BDGA 5EGHA 5K4PA 3DPCA 1ANJA 4KAVA 2W5WA 3SZYA 3NKNA 1SHQA 3UN5A 2GA3A 2W8SA 3CMRA 4TN0A 4UOOA 3IDDA 2X98A 1K7HA 3Q3QA 3BDFA 3A52A 4LR9A 2IFYA 4UORA 1AJCA 1AUKA 3LXQA 4YR1A 4FDJA 3NKMA 4GTYA 1EW9A 2GLQA 1ALHA 4GTXA 1KH4A 2W5RA 1EW8A 4LQYA 3TX0A 1HDHA 1N2LA 1O98A 3NKQA 4GTZA 4ZGAA 1AJAA 3UNYA 1EQJA 3ED4A 4ZG7A 1KH5A 1P49A 5AJ9A 5L0EA 4LRCA 1ALIA 2ZKTA 1KHJA 1ANIA 1HJKA 4UPIA 2ANHA 4CXKA 3NKRA 1KH7A 1E3CP 2XRGA 2W5TA 3WBHA 1AJDA 2XR9A 2RH6A 3WAYA 4UPLA 4KJGA 3UN2A 3IGYB 4GTWA 3MK0A 1E2SP 3WAWA 4MHXA 1O99A 2W5SA 2W5XA 4N7TA 1ALJA 4MY4A 1URBA 4KJDA 5TJ3A 3T00A 1ED9A 3M8ZA 1SHNA 3TG0A 3M7VA 4CXUA 5HRTA 1ALKA 2D1GA 3E2DA 2IUCB 3BDHA 1ELYA 3NKOA 4NWJA 5C66A 4UPKA 2GSOA 3M8WA 5EGEA 4KAYA 1E33P 4LR2A 1E1ZP 4KM4A 1B8JA 3KD8A 1ZEBA 4LR7A 5IJSA 4LRFA 1KHLA 1AJBA 1ZEDA 4MIVA 1Y7AA 3WAXA 1ED8A 5L0BA 5LIAA 1EW2A 2GSUA 3T02A 3OT9A 4ZG9A 2VQRA 2GSNA 4LRBA 3B5QA 3WAVA 3IGZB 4LRAA 5L0KA 4UOPA 2QZUA 1KHNA 1Y6VA 1KH9A 4ZG6A 3NVLA 3UO0A 4QAXA 4B56A 1ELXA 4UPHA 1EI6A 1URAA 3MK1A 5LQQA 4CYRA 4CYSA 5DLTA 5DLWA 5INHA 3NKPA 4LREA 5LRNA 5DLVA 1HQAA 3T01A 1KHKA 1EJJA 4LR8A 5LRMA 3MK2A 2W5VA 3M8YA 1ZEFA 5GRRA 1FSUA 3TWZA 1ELZA
chains in the Genus database with same CATH superfamily
1N2KA 2IUCA 4NWXA 3SZZA 2G9YA 3UN3A 5GOVA 4CXSA 2W8DA 3BDGB 4FDIA 2W5QA 4LRDA 5KXAA 5IJQA 3DYCA 3BDGA 5EGHA 5K4PA 3DPCA 1ANJA 4KAVA 2W5WA 3SZYA 3NKNA 1SHQA 3UN5A 2GA3A 2W8SA 3CMRA 4TN0A 4UOOA 3IDDA 2X98A 1K7HA 3Q3QA 3BDFA 3A52A 4LR9A 2IFYA 4UORA 1AJCA 1AUKA 3LXQA 4YR1A 4FDJA 3NKMA 4GTYA 1EW9A 2GLQA 1ALHA 4GTXA 1KH4A 2W5RA 1EW8A 4LQYA 3TX0A 1HDHA 1N2LA 1O98A 3NKQA 4GTZA 4ZGAA 1AJAA 3UNYA 1EQJA 3ED4A 4ZG7A 1KH5A 1P49A 5AJ9A 5L0EA 4LRCA 1ALIA 2ZKTA 1KHJA 1ANIA 1HJKA 4UPIA 2ANHA 4CXKA 3NKRA 1KH7A 1E3CP 2XRGA 2W5TA 3WBHA 1AJDA 2XR9A 2RH6A 3WAYA 4UPLA 4KJGA 3UN2A 3IGYB 4GTWA 3MK0A 1E2SP 3WAWA 4MHXA 1O99A 2W5SA 2W5XA 4N7TA 1ALJA 4MY4A 1URBA 4KJDA 5TJ3A 3T00A 1ED9A 3M8ZA 1SHNA 3TG0A 3M7VA 4CXUA 5HRTA 1ALKA 2D1GA 3E2DA 2IUCB 3BDHA 1ELYA 3NKOA 4NWJA 5C66A 4UPKA 2GSOA 3M8WA 5EGEA 4KAYA 1E33P 4LR2A 1E1ZP 4KM4A 1B8JA 3KD8A 1ZEBA 4LR7A 5IJSA 4LRFA 1KHLA 1AJBA 1ZEDA 4MIVA 1Y7AA 3WAXA 1ED8A 5L0BA 5LIAA 1EW2A 2GSUA 3T02A 3OT9A 4ZG9A 2VQRA 2GSNA 4LRBA 3B5QA 3WAVA 3IGZB 4LRAA 5L0KA 4UOPA 2QZUA 1KHNA 1Y6VA 1KH9A 4ZG6A 3NVLA 3UO0A 4QAXA 4B56A 1ELXA 4UPHA 1EI6A 1URAA 3MK1A 5LQQA 4CYRA 4CYSA 5DLTA 5DLWA 5INHA 3NKPA 4LREA 5LRNA 5DLVA 1HQAA 3T01A 1KHKA 1EJJA 4LR8A 5LRMA 3MK2A 2W5VA 3M8YA 1ZEFA 5GRRA 1FSUA 3TWZA 1ELZA
chains in the Genus database with same CATH topology
1N2KA 2IUCA 4NWXA 3SZZA 2G9YA 3UN3A 5GOVA 4CXSA 2W8DA 3BDGB 4FDIA 2W5QA 4LRDA 5KXAA 5IJQA 3DYCA 3BDGA 5EGHA 5K4PA 3DPCA 1ANJA 4KAVA 2W5WA 3SZYA 3NKNA 1SHQA 3UN5A 2GA3A 2W8SA 3CMRA 4TN0A 4UOOA 3IDDA 2X98A 1K7HA 3Q3QA 3BDFA 3A52A 4LR9A 2IFYA 4UORA 1AJCA 1AUKA 3LXQA 4YR1A 4FDJA 3NKMA 4GTYA 1EW9A 2GLQA 1ALHA 4GTXA 1KH4A 2W5RA 1EW8A 4LQYA 3TX0A 1HDHA 1N2LA 1O98A 3NKQA 4GTZA 4ZGAA 1AJAA 3UNYA 1EQJA 3ED4A 4ZG7A 1KH5A 1P49A 5AJ9A 5L0EA 4LRCA 1ALIA 2ZKTA 1KHJA 1ANIA 1HJKA 4UPIA 2ANHA 4CXKA 3NKRA 1KH7A 1E3CP 2XRGA 2W5TA 3WBHA 1AJDA 2XR9A 2RH6A 3WAYA 4UPLA 4KJGA 3UN2A 3IGYB 4GTWA 3MK0A 1E2SP 3WAWA 4MHXA 1O99A 2W5SA 2W5XA 4N7TA 1ALJA 4MY4A 1URBA 4KJDA 5TJ3A 3T00A 1ED9A 3M8ZA 1SHNA 3TG0A 3M7VA 4CXUA 5HRTA 1ALKA 2D1GA 3E2DA 2IUCB 3BDHA 1ELYA 3NKOA 4NWJA 5C66A 4UPKA 2GSOA 3M8WA 5EGEA 4KAYA 1E33P 4LR2A 1E1ZP 4KM4A 1B8JA 3KD8A 1ZEBA 4LR7A 5IJSA 4LRFA 1KHLA 1AJBA 1ZEDA 4MIVA 1Y7AA 3WAXA 1ED8A 5L0BA 5LIAA 1EW2A 2GSUA 3T02A 3OT9A 4ZG9A 2VQRA 2GSNA 4LRBA 3B5QA 3WAVA 3IGZB 4LRAA 5L0KA 4UOPA 2QZUA 1KHNA 1Y6VA 1KH9A 4ZG6A 3NVLA 3UO0A 4QAXA 4B56A 1ELXA 4UPHA 1EI6A 1URAA 3MK1A 5LQQA 4CYRA 4CYSA 5DLTA 5DLWA 5INHA 3NKPA 4LREA 5LRNA 5DLVA 1HQAA 3T01A 1KHKA 1EJJA 4LR8A 5LRMA 3MK2A 2W5VA 3M8YA 1ZEFA 5GRRA 1FSUA 3TWZA 1ELZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N2K A;  2IUC A;  4NWX A;  3SZZ A;  2G9Y A;  3UN3 A;  5GOV A;  4CXS A;  2W8D A;  3BDG B;  4FDI A;  2W5Q A;  4LRD A;  5KXA A;  5IJQ A;  3DYC A;  3BDG A;  5EGH A;  5K4P A;  3DPC A;  1ANJ A;  4KAV A;  2W5W A;  3SZY A;  3NKN A;  1SHQ A;  3UN5 A;  2GA3 A;  2W8S A;  3CMR A;  4TN0 A;  4UOO A;  3IDD A;  2X98 A;  1K7H A;  3Q3Q A;  3BDF A;  3A52 A;  4LR9 A;  2IFY A;  4UOR A;  1AJC A;  1AUK A;  3LXQ A;  4YR1 A;  4FDJ A;  3NKM A;  4GTY A;  1EW9 A;  2GLQ A;  1ALH A;  4GTX A;  1KH4 A;  2W5R A;  1EW8 A;  4LQY A;  3TX0 A;  1HDH A;  1N2L A;  1O98 A;  3NKQ A;  4GTZ A;  4ZGA A;  1AJA A;  3UNY A;  1EQJ A;  3ED4 A;  4ZG7 A;  1KH5 A;  1P49 A;  5AJ9 A;  5L0E A;  4LRC A;  1ALI A;  2ZKT A;  1KHJ A;  1ANI A;  1HJK A;  4UPI A;  2ANH A;  4CXK A;  3NKR A;  1KH7 A;  1E3C P;  2XRG A;  2W5T A;  3WBH A;  1AJD A;  2XR9 A;  2RH6 A;  3WAY A;  4UPL A;  4KJG A;  3UN2 A;  3IGY B;  4GTW A;  3MK0 A;  1E2S P;  3WAW A;  4MHX A;  1O99 A;  2W5S A;  2W5X A;  4N7T A;  1ALJ A;  4MY4 A;  1URB A;  4KJD A;  5TJ3 A;  3T00 A;  1ED9 A;  3M8Z A;  1SHN A;  3TG0 A;  3M7V A;  4CXU A;  5HRT A;  1ALK A;  2D1G A;  3E2D A;  2IUC B;  3BDH A;  1ELY A;  3NKO A;  4NWJ A;  5C66 A;  4UPK A;  2GSO A;  3M8W A;  5EGE A;  4KAY A;  1E33 P;  4LR2 A;  1E1Z P;  4KM4 A;  1B8J A;  3KD8 A;  1ZEB A;  4LR7 A;  5IJS A;  4LRF A;  1KHL A;  1AJB A;  1ZED A;  4MIV A;  1Y7A A;  3WAX A;  1ED8 A;  5L0B A;  5LIA A;  1EW2 A;  2GSU A;  3T02 A;  3OT9 A;  4ZG9 A;  2VQR A;  2GSN A;  4LRB A;  3B5Q A;  3WAV A;  3IGZ B;  4LRA A;  5L0K A;  4UOP A;  2QZU A;  1KHN A;  1Y6V A;  1KH9 A;  4ZG6 A;  3NVL A;  3UO0 A;  4QAX A;  4B56 A;  1ELX A;  4UPH A;  1EI6 A;  1URA A;  3MK1 A;  5LQQ A;  4CYR A;  4CYS A;  5DLT A;  5DLW A;  5INH A;  3NKP A;  4LRE A;  5LRN A;  5DLV A;  1HQA A;  3T01 A;  1KHK A;  1EJJ A;  4LR8 A;  5LRM A;  3MK2 A;  2W5V A;  3M8Y A;  1ZEF A;  5GRR A;  1FSU A;  3TWZ A;  1ELZ A; 
#chains in the Genus database with same CATH topology
 1N2K A;  2IUC A;  4NWX A;  3SZZ A;  2G9Y A;  3UN3 A;  5GOV A;  4CXS A;  2W8D A;  3BDG B;  4FDI A;  2W5Q A;  4LRD A;  5KXA A;  5IJQ A;  3DYC A;  3BDG A;  5EGH A;  5K4P A;  3DPC A;  1ANJ A;  4KAV A;  2W5W A;  3SZY A;  3NKN A;  1SHQ A;  3UN5 A;  2GA3 A;  2W8S A;  3CMR A;  4TN0 A;  4UOO A;  3IDD A;  2X98 A;  1K7H A;  3Q3Q A;  3BDF A;  3A52 A;  4LR9 A;  2IFY A;  4UOR A;  1AJC A;  1AUK A;  3LXQ A;  4YR1 A;  4FDJ A;  3NKM A;  4GTY A;  1EW9 A;  2GLQ A;  1ALH A;  4GTX A;  1KH4 A;  2W5R A;  1EW8 A;  4LQY A;  3TX0 A;  1HDH A;  1N2L A;  1O98 A;  3NKQ A;  4GTZ A;  4ZGA A;  1AJA A;  3UNY A;  1EQJ A;  3ED4 A;  4ZG7 A;  1KH5 A;  1P49 A;  5AJ9 A;  5L0E A;  4LRC A;  1ALI A;  2ZKT A;  1KHJ A;  1ANI A;  1HJK A;  4UPI A;  2ANH A;  4CXK A;  3NKR A;  1KH7 A;  1E3C P;  2XRG A;  2W5T A;  3WBH A;  1AJD A;  2XR9 A;  2RH6 A;  3WAY A;  4UPL A;  4KJG A;  3UN2 A;  3IGY B;  4GTW A;  3MK0 A;  1E2S P;  3WAW A;  4MHX A;  1O99 A;  2W5S A;  2W5X A;  4N7T A;  1ALJ A;  4MY4 A;  1URB A;  4KJD A;  5TJ3 A;  3T00 A;  1ED9 A;  3M8Z A;  1SHN A;  3TG0 A;  3M7V A;  4CXU A;  5HRT A;  1ALK A;  2D1G A;  3E2D A;  2IUC B;  3BDH A;  1ELY A;  3NKO A;  4NWJ A;  5C66 A;  4UPK A;  2GSO A;  3M8W A;  5EGE A;  4KAY A;  1E33 P;  4LR2 A;  1E1Z P;  4KM4 A;  1B8J A;  3KD8 A;  1ZEB A;  4LR7 A;  5IJS A;  4LRF A;  1KHL A;  1AJB A;  1ZED A;  4MIV A;  1Y7A A;  3WAX A;  1ED8 A;  5L0B A;  5LIA A;  1EW2 A;  2GSU A;  3T02 A;  3OT9 A;  4ZG9 A;  2VQR A;  2GSN A;  4LRB A;  3B5Q A;  3WAV A;  3IGZ B;  4LRA A;  5L0K A;  4UOP A;  2QZU A;  1KHN A;  1Y6V A;  1KH9 A;  4ZG6 A;  3NVL A;  3UO0 A;  4QAX A;  4B56 A;  1ELX A;  4UPH A;  1EI6 A;  1URA A;  3MK1 A;  5LQQ A;  4CYR A;  4CYS A;  5DLT A;  5DLW A;  5INH A;  3NKP A;  4LRE A;  5LRN A;  5DLV A;  1HQA A;  3T01 A;  1KHK A;  1EJJ A;  4LR8 A;  5LRM A;  3MK2 A;  2W5V A;  3M8Y A;  1ZEF A;  5GRR A;  1FSU A;  3TWZ A;  1ELZ A; 
#chains in the Genus database with same CATH homology
 1N2K A;  2IUC A;  4NWX A;  3SZZ A;  2G9Y A;  3UN3 A;  5GOV A;  4CXS A;  2W8D A;  3BDG B;  4FDI A;  2W5Q A;  4LRD A;  5KXA A;  5IJQ A;  3DYC A;  3BDG A;  5EGH A;  5K4P A;  3DPC A;  1ANJ A;  4KAV A;  2W5W A;  3SZY A;  3NKN A;  1SHQ A;  3UN5 A;  2GA3 A;  2W8S A;  3CMR A;  4TN0 A;  4UOO A;  3IDD A;  2X98 A;  1K7H A;  3Q3Q A;  3BDF A;  3A52 A;  4LR9 A;  2IFY A;  4UOR A;  1AJC A;  1AUK A;  3LXQ A;  4YR1 A;  4FDJ A;  3NKM A;  4GTY A;  1EW9 A;  2GLQ A;  1ALH A;  4GTX A;  1KH4 A;  2W5R A;  1EW8 A;  4LQY A;  3TX0 A;  1HDH A;  1N2L A;  1O98 A;  3NKQ A;  4GTZ A;  4ZGA A;  1AJA A;  3UNY A;  1EQJ A;  3ED4 A;  4ZG7 A;  1KH5 A;  1P49 A;  5AJ9 A;  5L0E A;  4LRC A;  1ALI A;  2ZKT A;  1KHJ A;  1ANI A;  1HJK A;  4UPI A;  2ANH A;  4CXK A;  3NKR A;  1KH7 A;  1E3C P;  2XRG A;  2W5T A;  3WBH A;  1AJD A;  2XR9 A;  2RH6 A;  3WAY A;  4UPL A;  4KJG A;  3UN2 A;  3IGY B;  4GTW A;  3MK0 A;  1E2S P;  3WAW A;  4MHX A;  1O99 A;  2W5S A;  2W5X A;  4N7T A;  1ALJ A;  4MY4 A;  1URB A;  4KJD A;  5TJ3 A;  3T00 A;  1ED9 A;  3M8Z A;  1SHN A;  3TG0 A;  3M7V A;  4CXU A;  5HRT A;  1ALK A;  2D1G A;  3E2D A;  2IUC B;  3BDH A;  1ELY A;  3NKO A;  4NWJ A;  5C66 A;  4UPK A;  2GSO A;  3M8W A;  5EGE A;  4KAY A;  1E33 P;  4LR2 A;  1E1Z P;  4KM4 A;  1B8J A;  3KD8 A;  1ZEB A;  4LR7 A;  5IJS A;  4LRF A;  1KHL A;  1AJB A;  1ZED A;  4MIV A;  1Y7A A;  3WAX A;  1ED8 A;  5L0B A;  5LIA A;  1EW2 A;  2GSU A;  3T02 A;  3OT9 A;  4ZG9 A;  2VQR A;  2GSN A;  4LRB A;  3B5Q A;  3WAV A;  3IGZ B;  4LRA A;  5L0K A;  4UOP A;  2QZU A;  1KHN A;  1Y6V A;  1KH9 A;  4ZG6 A;  3NVL A;  3UO0 A;  4QAX A;  4B56 A;  1ELX A;  4UPH A;  1EI6 A;  1URA A;  3MK1 A;  5LQQ A;  4CYR A;  4CYS A;  5DLT A;  5DLW A;  5INH A;  3NKP A;  4LRE A;  5LRN A;  5DLV A;  1HQA A;  3T01 A;  1KHK A;  1EJJ A;  4LR8 A;  5LRM A;  3MK2 A;  2W5V A;  3M8Y A;  1ZEF A;  5GRR A;  1FSU A;  3TWZ A;  1ELZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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