4MHXA

Crystal structure of sulfamidase
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
483
structure length
482
Chain Sequence
PRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWVCAPDGVLEEKLSPQCQPLHNELRS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords N-sulphoglucosamine sulphohydrolase
publication title Structure of sulfamidase provides insight into the molecular pathology of mucopolysaccharidosis IIIA.
pubmed doi rcsb
source organism Homo sapiens
total genus 167
structure length 482
sequence length 483
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.10.1.1: N-sulfoglucosamine sulfohydrolase.
pdb deposition date 2013-08-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
A PF16347 DUF4976 Domain of unknown function (DUF4976)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4mhxA01
4LREA 1AJAA 3KD8A 5EGHA 4CXKA 3UN5A 1ALKA 4UPLA 4KJDA 2IUCA 1ZEDA 1HDHA 2W5RA 1ALIA 3IGZB 4KAVA 1KH7A 2VQRA 4LRFA 4ZG7A 3LXQA 4UORA 4ZG9A 1ALHA 1SHNA 1FSUA 5IJQA 4UOPA 2GSUA 5L0KA 1E2SP 4UPIA 3WAWA 3B5QA 4LRCA 2IUCB 2GA3A 1B8JA 4CXSA 3UO0A 1ELYA 1KHLA 5L0EA 1E33P 4YR1A 1AJDA 3MK2A 2W8SA 2ANHA 5LQQA 1HQAA 5KXAA 5LIAA 5TJ3A 3M8YA 1KHNA 1E1ZP 5DLVA 1ANJA 2W5QA 1ALJA 4LR8A 2D1GA 1Y7AA 1AJBA 4TN0A 5GOVA 3IGYB 2G9YA 4FDJA 3BDHA 4QAXA 3T02A 1KH9A 3OT9A 1ZEBA 1EW9A 3UN3A 1ELXA 3NKMA 4MIVA 1KH4A 1ANIA 2RH6A 1HJKA 3NKNA 2GSOA 1E3CP 4NWXA 5EGEA 4GTYA 3ED4A 3NVLA 1ZEFA 2W5SA 5C66A 3WBHA 1EQJA 4GTWA 5K4PA 3M8WA 3CMRA 5INHA 3T01A 4LQYA 5GRRA 1ED9A 2XR9A 3WAXA 2GSNA 1KH5A 2W5WA 1AJCA 1O98A 1KHKA 3UN2A 3NKOA 1EI6A 3NKQA 5DLTA 4LRAA 3TX0A 1EW2A 4UOOA 4UPHA 1EW8A 3IDDA 4ZGAA 3TG0A 4LR7A 3SZZA 1EJJA 3M8ZA 4KAYA 2IFYA 2W5VA 4CYRA 3DYCA 1N2KA 1URBA 3DPCA 3Q3QA 3MK1A 4CYSA 5LRMA 1SHQA 4LR9A 2QZUA 5L0BA 1ELZA 2ZKTA 4GTZA 3T00A 1P49A 2GLQA 4LRBA 2XRGA 2W5TA 4N7TA 1KHJA 3NKRA 4CXUA 3BDGA 2X98A 4GTXA 4LR2A 1URAA 4KJGA 3UNYA 5AJ9A 2W8DA 4MHXA 4KM4A 3SZYA 3NKPA 4FDIA 3WAYA 1N2LA 4ZG6A 1ED8A 3A52A 4UPKA 3MK0A 4B56A 3BDFA 5HRTA 3M7VA 3BDGB 4LRDA 4NWJA 5IJSA 3WAVA 5LRNA 1K7HA 5DLWA 1O99A 3TWZA 3E2DA 1AUKA 1Y6VA 2W5XA 4MY4A
chains in the Genus database with same CATH superfamily
4LREA 1AJAA 3KD8A 5EGHA 4CXKA 3UN5A 1ALKA 4UPLA 4KJDA 2IUCA 1ZEDA 1HDHA 2W5RA 1ALIA 3IGZB 4KAVA 1KH7A 2VQRA 4LRFA 4ZG7A 3LXQA 4UORA 4ZG9A 1ALHA 1SHNA 1FSUA 5IJQA 4UOPA 2GSUA 5L0KA 1E2SP 4UPIA 3WAWA 3B5QA 4LRCA 2IUCB 2GA3A 1B8JA 4CXSA 3UO0A 1ELYA 1KHLA 5L0EA 1E33P 4YR1A 1AJDA 3MK2A 2W8SA 2ANHA 5LQQA 1HQAA 5KXAA 5LIAA 5TJ3A 3M8YA 1KHNA 1E1ZP 5DLVA 1ANJA 2W5QA 1ALJA 4LR8A 2D1GA 1Y7AA 1AJBA 4TN0A 5GOVA 3IGYB 2G9YA 4FDJA 3BDHA 4QAXA 3T02A 1KH9A 3OT9A 1ZEBA 1EW9A 3UN3A 1ELXA 3NKMA 4MIVA 1KH4A 1ANIA 2RH6A 1HJKA 3NKNA 2GSOA 1E3CP 4NWXA 5EGEA 4GTYA 3ED4A 3NVLA 1ZEFA 2W5SA 5C66A 3WBHA 1EQJA 4GTWA 5K4PA 3M8WA 3CMRA 5INHA 3T01A 4LQYA 5GRRA 1ED9A 2XR9A 3WAXA 2GSNA 1KH5A 2W5WA 1AJCA 1O98A 1KHKA 3UN2A 3NKOA 1EI6A 3NKQA 5DLTA 4LRAA 3TX0A 1EW2A 4UOOA 4UPHA 1EW8A 3IDDA 4ZGAA 3TG0A 4LR7A 3SZZA 1EJJA 3M8ZA 4KAYA 2IFYA 2W5VA 4CYRA 3DYCA 1N2KA 1URBA 3DPCA 3Q3QA 3MK1A 4CYSA 5LRMA 1SHQA 4LR9A 2QZUA 5L0BA 1ELZA 2ZKTA 4GTZA 3T00A 1P49A 2GLQA 4LRBA 2XRGA 2W5TA 4N7TA 1KHJA 3NKRA 4CXUA 3BDGA 2X98A 4GTXA 4LR2A 1URAA 4KJGA 3UNYA 5AJ9A 2W8DA 4MHXA 4KM4A 3SZYA 3NKPA 4FDIA 3WAYA 1N2LA 4ZG6A 1ED8A 3A52A 4UPKA 3MK0A 4B56A 3BDFA 5HRTA 3M7VA 3BDGB 4LRDA 4NWJA 5IJSA 3WAVA 5LRNA 1K7HA 5DLWA 1O99A 3TWZA 3E2DA 1AUKA 1Y6VA 2W5XA 4MY4A
chains in the Genus database with same CATH topology
4LREA 1AJAA 3KD8A 5EGHA 4CXKA 3UN5A 1ALKA 4UPLA 4KJDA 2IUCA 1ZEDA 1HDHA 2W5RA 1ALIA 3IGZB 4KAVA 1KH7A 2VQRA 4LRFA 4ZG7A 3LXQA 4UORA 4ZG9A 1ALHA 1SHNA 1FSUA 5IJQA 4UOPA 2GSUA 5L0KA 1E2SP 4UPIA 3WAWA 3B5QA 4LRCA 2IUCB 2GA3A 1B8JA 4CXSA 3UO0A 1ELYA 1KHLA 5L0EA 1E33P 4YR1A 1AJDA 3MK2A 2W8SA 2ANHA 5LQQA 1HQAA 5KXAA 5LIAA 5TJ3A 3M8YA 1KHNA 1E1ZP 5DLVA 1ANJA 2W5QA 1ALJA 4LR8A 2D1GA 1Y7AA 1AJBA 4TN0A 5GOVA 3IGYB 2G9YA 4FDJA 3BDHA 4QAXA 3T02A 1KH9A 3OT9A 1ZEBA 1EW9A 3UN3A 1ELXA 3NKMA 4MIVA 1KH4A 1ANIA 2RH6A 1HJKA 3NKNA 2GSOA 1E3CP 4NWXA 5EGEA 4GTYA 3ED4A 3NVLA 1ZEFA 2W5SA 5C66A 3WBHA 1EQJA 4GTWA 5K4PA 3M8WA 3CMRA 5INHA 3T01A 4LQYA 5GRRA 1ED9A 2XR9A 3WAXA 2GSNA 1KH5A 2W5WA 1AJCA 1O98A 1KHKA 3UN2A 3NKOA 1EI6A 3NKQA 5DLTA 4LRAA 3TX0A 1EW2A 4UOOA 4UPHA 1EW8A 3IDDA 4ZGAA 3TG0A 4LR7A 3SZZA 1EJJA 3M8ZA 4KAYA 2IFYA 2W5VA 4CYRA 3DYCA 1N2KA 1URBA 3DPCA 3Q3QA 3MK1A 4CYSA 5LRMA 1SHQA 4LR9A 2QZUA 5L0BA 1ELZA 2ZKTA 4GTZA 3T00A 1P49A 2GLQA 4LRBA 2XRGA 2W5TA 4N7TA 1KHJA 3NKRA 4CXUA 3BDGA 2X98A 4GTXA 4LR2A 1URAA 4KJGA 3UNYA 5AJ9A 2W8DA 4MHXA 4KM4A 3SZYA 3NKPA 4FDIA 3WAYA 1N2LA 4ZG6A 1ED8A 3A52A 4UPKA 3MK0A 4B56A 3BDFA 5HRTA 3M7VA 3BDGB 4LRDA 4NWJA 5IJSA 3WAVA 5LRNA 1K7HA 5DLWA 1O99A 3TWZA 3E2DA 1AUKA 1Y6VA 2W5XA 4MY4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRE A;  1AJA A;  3KD8 A;  5EGH A;  4CXK A;  3UN5 A;  1ALK A;  4UPL A;  4KJD A;  2IUC A;  1ZED A;  1HDH A;  2W5R A;  1ALI A;  3IGZ B;  4KAV A;  1KH7 A;  2VQR A;  4LRF A;  4ZG7 A;  3LXQ A;  4UOR A;  4ZG9 A;  1ALH A;  1SHN A;  1FSU A;  5IJQ A;  4UOP A;  2GSU A;  5L0K A;  1E2S P;  4UPI A;  3WAW A;  3B5Q A;  4LRC A;  2IUC B;  2GA3 A;  1B8J A;  4CXS A;  3UO0 A;  1ELY A;  1KHL A;  5L0E A;  1E33 P;  4YR1 A;  1AJD A;  3MK2 A;  2W8S A;  2ANH A;  5LQQ A;  1HQA A;  5KXA A;  5LIA A;  5TJ3 A;  3M8Y A;  1KHN A;  1E1Z P;  5DLV A;  1ANJ A;  2W5Q A;  1ALJ A;  4LR8 A;  2D1G A;  1Y7A A;  1AJB A;  4TN0 A;  5GOV A;  3IGY B;  2G9Y A;  4FDJ A;  3BDH A;  4QAX A;  3T02 A;  1KH9 A;  3OT9 A;  1ZEB A;  1EW9 A;  3UN3 A;  1ELX A;  3NKM A;  4MIV A;  1KH4 A;  1ANI A;  2RH6 A;  1HJK A;  3NKN A;  2GSO A;  1E3C P;  4NWX A;  5EGE A;  4GTY A;  3ED4 A;  3NVL A;  1ZEF A;  2W5S A;  5C66 A;  3WBH A;  1EQJ A;  4GTW A;  5K4P A;  3M8W A;  3CMR A;  5INH A;  3T01 A;  4LQY A;  5GRR A;  1ED9 A;  2XR9 A;  3WAX A;  2GSN A;  1KH5 A;  2W5W A;  1AJC A;  1O98 A;  1KHK A;  3UN2 A;  3NKO A;  1EI6 A;  3NKQ A;  5DLT A;  4LRA A;  3TX0 A;  1EW2 A;  4UOO A;  4UPH A;  1EW8 A;  3IDD A;  4ZGA A;  3TG0 A;  4LR7 A;  3SZZ A;  1EJJ A;  3M8Z A;  4KAY A;  2IFY A;  2W5V A;  4CYR A;  3DYC A;  1N2K A;  1URB A;  3DPC A;  3Q3Q A;  3MK1 A;  4CYS A;  5LRM A;  1SHQ A;  4LR9 A;  2QZU A;  5L0B A;  1ELZ A;  2ZKT A;  4GTZ A;  3T00 A;  1P49 A;  2GLQ A;  4LRB A;  2XRG A;  2W5T A;  4N7T A;  1KHJ A;  3NKR A;  4CXU A;  3BDG A;  2X98 A;  4GTX A;  4LR2 A;  1URA A;  4KJG A;  3UNY A;  5AJ9 A;  2W8D A;  4MHX A;  4KM4 A;  3SZY A;  3NKP A;  4FDI A;  3WAY A;  1N2L A;  4ZG6 A;  1ED8 A;  3A52 A;  4UPK A;  3MK0 A;  4B56 A;  3BDF A;  5HRT A;  3M7V A;  3BDG B;  4LRD A;  4NWJ A;  5IJS A;  3WAV A;  5LRN A;  1K7H A;  5DLW A;  1O99 A;  3TWZ A;  3E2D A;  1AUK A;  1Y6V A;  2W5X A;  4MY4 A; 
#chains in the Genus database with same CATH topology
 4LRE A;  1AJA A;  3KD8 A;  5EGH A;  4CXK A;  3UN5 A;  1ALK A;  4UPL A;  4KJD A;  2IUC A;  1ZED A;  1HDH A;  2W5R A;  1ALI A;  3IGZ B;  4KAV A;  1KH7 A;  2VQR A;  4LRF A;  4ZG7 A;  3LXQ A;  4UOR A;  4ZG9 A;  1ALH A;  1SHN A;  1FSU A;  5IJQ A;  4UOP A;  2GSU A;  5L0K A;  1E2S P;  4UPI A;  3WAW A;  3B5Q A;  4LRC A;  2IUC B;  2GA3 A;  1B8J A;  4CXS A;  3UO0 A;  1ELY A;  1KHL A;  5L0E A;  1E33 P;  4YR1 A;  1AJD A;  3MK2 A;  2W8S A;  2ANH A;  5LQQ A;  1HQA A;  5KXA A;  5LIA A;  5TJ3 A;  3M8Y A;  1KHN A;  1E1Z P;  5DLV A;  1ANJ A;  2W5Q A;  1ALJ A;  4LR8 A;  2D1G A;  1Y7A A;  1AJB A;  4TN0 A;  5GOV A;  3IGY B;  2G9Y A;  4FDJ A;  3BDH A;  4QAX A;  3T02 A;  1KH9 A;  3OT9 A;  1ZEB A;  1EW9 A;  3UN3 A;  1ELX A;  3NKM A;  4MIV A;  1KH4 A;  1ANI A;  2RH6 A;  1HJK A;  3NKN A;  2GSO A;  1E3C P;  4NWX A;  5EGE A;  4GTY A;  3ED4 A;  3NVL A;  1ZEF A;  2W5S A;  5C66 A;  3WBH A;  1EQJ A;  4GTW A;  5K4P A;  3M8W A;  3CMR A;  5INH A;  3T01 A;  4LQY A;  5GRR A;  1ED9 A;  2XR9 A;  3WAX A;  2GSN A;  1KH5 A;  2W5W A;  1AJC A;  1O98 A;  1KHK A;  3UN2 A;  3NKO A;  1EI6 A;  3NKQ A;  5DLT A;  4LRA A;  3TX0 A;  1EW2 A;  4UOO A;  4UPH A;  1EW8 A;  3IDD A;  4ZGA A;  3TG0 A;  4LR7 A;  3SZZ A;  1EJJ A;  3M8Z A;  4KAY A;  2IFY A;  2W5V A;  4CYR A;  3DYC A;  1N2K A;  1URB A;  3DPC A;  3Q3Q A;  3MK1 A;  4CYS A;  5LRM A;  1SHQ A;  4LR9 A;  2QZU A;  5L0B A;  1ELZ A;  2ZKT A;  4GTZ A;  3T00 A;  1P49 A;  2GLQ A;  4LRB A;  2XRG A;  2W5T A;  4N7T A;  1KHJ A;  3NKR A;  4CXU A;  3BDG A;  2X98 A;  4GTX A;  4LR2 A;  1URA A;  4KJG A;  3UNY A;  5AJ9 A;  2W8D A;  4MHX A;  4KM4 A;  3SZY A;  3NKP A;  4FDI A;  3WAY A;  1N2L A;  4ZG6 A;  1ED8 A;  3A52 A;  4UPK A;  3MK0 A;  4B56 A;  3BDF A;  5HRT A;  3M7V A;  3BDG B;  4LRD A;  4NWJ A;  5IJS A;  3WAV A;  5LRN A;  1K7H A;  5DLW A;  1O99 A;  3TWZ A;  3E2D A;  1AUK A;  1Y6V A;  2W5X A;  4MY4 A; 
#chains in the Genus database with same CATH homology
 4LRE A;  1AJA A;  3KD8 A;  5EGH A;  4CXK A;  3UN5 A;  1ALK A;  4UPL A;  4KJD A;  2IUC A;  1ZED A;  1HDH A;  2W5R A;  1ALI A;  3IGZ B;  4KAV A;  1KH7 A;  2VQR A;  4LRF A;  4ZG7 A;  3LXQ A;  4UOR A;  4ZG9 A;  1ALH A;  1SHN A;  1FSU A;  5IJQ A;  4UOP A;  2GSU A;  5L0K A;  1E2S P;  4UPI A;  3WAW A;  3B5Q A;  4LRC A;  2IUC B;  2GA3 A;  1B8J A;  4CXS A;  3UO0 A;  1ELY A;  1KHL A;  5L0E A;  1E33 P;  4YR1 A;  1AJD A;  3MK2 A;  2W8S A;  2ANH A;  5LQQ A;  1HQA A;  5KXA A;  5LIA A;  5TJ3 A;  3M8Y A;  1KHN A;  1E1Z P;  5DLV A;  1ANJ A;  2W5Q A;  1ALJ A;  4LR8 A;  2D1G A;  1Y7A A;  1AJB A;  4TN0 A;  5GOV A;  3IGY B;  2G9Y A;  4FDJ A;  3BDH A;  4QAX A;  3T02 A;  1KH9 A;  3OT9 A;  1ZEB A;  1EW9 A;  3UN3 A;  1ELX A;  3NKM A;  4MIV A;  1KH4 A;  1ANI A;  2RH6 A;  1HJK A;  3NKN A;  2GSO A;  1E3C P;  4NWX A;  5EGE A;  4GTY A;  3ED4 A;  3NVL A;  1ZEF A;  2W5S A;  5C66 A;  3WBH A;  1EQJ A;  4GTW A;  5K4P A;  3M8W A;  3CMR A;  5INH A;  3T01 A;  4LQY A;  5GRR A;  1ED9 A;  2XR9 A;  3WAX A;  2GSN A;  1KH5 A;  2W5W A;  1AJC A;  1O98 A;  1KHK A;  3UN2 A;  3NKO A;  1EI6 A;  3NKQ A;  5DLT A;  4LRA A;  3TX0 A;  1EW2 A;  4UOO A;  4UPH A;  1EW8 A;  3IDD A;  4ZGA A;  3TG0 A;  4LR7 A;  3SZZ A;  1EJJ A;  3M8Z A;  4KAY A;  2IFY A;  2W5V A;  4CYR A;  3DYC A;  1N2K A;  1URB A;  3DPC A;  3Q3Q A;  3MK1 A;  4CYS A;  5LRM A;  1SHQ A;  4LR9 A;  2QZU A;  5L0B A;  1ELZ A;  2ZKT A;  4GTZ A;  3T00 A;  1P49 A;  2GLQ A;  4LRB A;  2XRG A;  2W5T A;  4N7T A;  1KHJ A;  3NKR A;  4CXU A;  3BDG A;  2X98 A;  4GTX A;  4LR2 A;  1URA A;  4KJG A;  3UNY A;  5AJ9 A;  2W8D A;  4MHX A;  4KM4 A;  3SZY A;  3NKP A;  4FDI A;  3WAY A;  1N2L A;  4ZG6 A;  1ED8 A;  3A52 A;  4UPK A;  3MK0 A;  4B56 A;  3BDF A;  5HRT A;  3M7V A;  3BDG B;  4LRD A;  4NWJ A;  5IJS A;  3WAV A;  5LRN A;  1K7H A;  5DLW A;  1O99 A;  3TWZ A;  3E2D A;  1AUK A;  1Y6V A;  2W5X A;  4MY4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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