1KHLA

E. coli alkaline phosphatase mutant (d153hd330n) complex with phosphate
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 150
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khlA00
3T00A 4UOOA 1ZEFA 1ALKA 4YR1A 3UN3A 1SHQA 1ELYA 3NKNA 4KAYA 1KH5A 1Y7AA 1SHNA 4LRCA 1ELZA 4UORA 3M8WA 2GLQA 3NKRA 5LRNA 2D1GA 3BDHA 4LRFA 1ED9A 3WBHA 1ED8A 2X98A 2IUCA 3IDDA 1ALJA 1N2LA 2GSUA 3IGYB 4NWJA 4CXKA 2GSNA 1HJKA 4KJDA 2XR9A 5TJ3A 1HQAA 4LRDA 5KXAA 4GTWA 3DPCA 1EI6A 1KHLA 3T01A 4KM4A 3LXQA 1URBA 4GTXA 3CMRA 3NKMA 2W5XA 3MK0A 1ZEBA 4N7TA 1ALHA 1ANIA 1EW2A 4FDIA 2W5VA 3MK1A 1E1ZP 3MK2A 5L0KA 3UNYA 3WAYA 4UOPA 5LIAA 3SZZA 5IJSA 3UN5A 4ZGAA 4KAVA 3IGZB 5L0BA 4MHXA 5L0EA 5HRTA 1B8JA 1EJJA 5C66A 5LQQA 5GOVA 4UPLA 2GA3A 3WAXA 1E33P 1EQJA 1P49A 3NKQA 3NKPA 5EGEA 1ELXA 1Y6VA 2GSOA 1URAA 4KJGA 4B56A 4CXUA 4CXSA 3NKOA 2W5TA 4MIVA 1E3CP 4TN0A 2W5WA 3WAWA 2G9YA 3TX0A 1O98A 3ED4A 3TG0A 1KH4A 4GTZA 2VQRA 1K7HA 2XRGA 3BDGB 1AUKA 4UPHA 4ZG6A 1KHNA 1HDHA 3M8YA 5GRRA 1KH9A 1KHKA 3A52A 1ZEDA 4CYSA 2W8SA 3WAVA 4MY4A 4LR7A 3KD8A 4LR2A 5LRMA 4LRBA 1AJDA 1KH7A 2IUCB 2QZUA 1ALIA 4GTYA 5DLVA 4LREA 3TWZA 5DLWA 5K4PA 1FSUA 2ANHA 2W5RA 1EW8A 3M7VA 1AJCA 4ZG9A 3Q3QA 4LR9A 4NWXA 4UPKA 3B5QA 1ANJA 4FDJA 2W5QA 3OT9A 3BDGA 4LR8A 3UN2A 4ZG7A 1AJBA 1AJAA 1EW9A 5IJQA 1KHJA 3E2DA 5AJ9A 2ZKTA 3DYCA 1E2SP 1N2KA 4QAXA 3SZYA 3M8ZA 4LRAA 2W8DA 2RH6A 5DLTA 3T02A 1O99A 3BDFA 3UO0A 4LQYA 5INHA 5EGHA 2IFYA 3NVLA 2W5SA 4UPIA 4CYRA
chains in the Genus database with same CATH superfamily
3T00A 4UOOA 1ZEFA 1ALKA 4YR1A 3UN3A 1SHQA 1ELYA 3NKNA 4KAYA 1KH5A 1Y7AA 1SHNA 4LRCA 1ELZA 4UORA 3M8WA 2GLQA 3NKRA 5LRNA 2D1GA 3BDHA 4LRFA 1ED9A 3WBHA 1ED8A 2X98A 2IUCA 3IDDA 1ALJA 1N2LA 2GSUA 3IGYB 4NWJA 4CXKA 2GSNA 1HJKA 4KJDA 2XR9A 5TJ3A 1HQAA 4LRDA 5KXAA 4GTWA 3DPCA 1EI6A 1KHLA 3T01A 4KM4A 3LXQA 1URBA 4GTXA 3CMRA 3NKMA 2W5XA 3MK0A 1ZEBA 4N7TA 1ALHA 1ANIA 1EW2A 4FDIA 2W5VA 3MK1A 1E1ZP 3MK2A 5L0KA 3UNYA 3WAYA 4UOPA 5LIAA 3SZZA 5IJSA 3UN5A 4ZGAA 4KAVA 3IGZB 5L0BA 4MHXA 5L0EA 5HRTA 1B8JA 1EJJA 5C66A 5LQQA 5GOVA 4UPLA 2GA3A 3WAXA 1E33P 1EQJA 1P49A 3NKQA 3NKPA 5EGEA 1ELXA 1Y6VA 2GSOA 1URAA 4KJGA 4B56A 4CXUA 4CXSA 3NKOA 2W5TA 4MIVA 1E3CP 4TN0A 2W5WA 3WAWA 2G9YA 3TX0A 1O98A 3ED4A 3TG0A 1KH4A 4GTZA 2VQRA 1K7HA 2XRGA 3BDGB 1AUKA 4UPHA 4ZG6A 1KHNA 1HDHA 3M8YA 5GRRA 1KH9A 1KHKA 3A52A 1ZEDA 4CYSA 2W8SA 3WAVA 4MY4A 4LR7A 3KD8A 4LR2A 5LRMA 4LRBA 1AJDA 1KH7A 2IUCB 2QZUA 1ALIA 4GTYA 5DLVA 4LREA 3TWZA 5DLWA 5K4PA 1FSUA 2ANHA 2W5RA 1EW8A 3M7VA 1AJCA 4ZG9A 3Q3QA 4LR9A 4NWXA 4UPKA 3B5QA 1ANJA 4FDJA 2W5QA 3OT9A 3BDGA 4LR8A 3UN2A 4ZG7A 1AJBA 1AJAA 1EW9A 5IJQA 1KHJA 3E2DA 5AJ9A 2ZKTA 3DYCA 1E2SP 1N2KA 4QAXA 3SZYA 3M8ZA 4LRAA 2W8DA 2RH6A 5DLTA 3T02A 1O99A 3BDFA 3UO0A 4LQYA 5INHA 5EGHA 2IFYA 3NVLA 2W5SA 4UPIA 4CYRA
chains in the Genus database with same CATH topology
3T00A 4UOOA 1ZEFA 1ALKA 4YR1A 3UN3A 1SHQA 1ELYA 3NKNA 4KAYA 1KH5A 1Y7AA 1SHNA 4LRCA 1ELZA 4UORA 3M8WA 2GLQA 3NKRA 5LRNA 2D1GA 3BDHA 4LRFA 1ED9A 3WBHA 1ED8A 2X98A 2IUCA 3IDDA 1ALJA 1N2LA 2GSUA 3IGYB 4NWJA 4CXKA 2GSNA 1HJKA 4KJDA 2XR9A 5TJ3A 1HQAA 4LRDA 5KXAA 4GTWA 3DPCA 1EI6A 1KHLA 3T01A 4KM4A 3LXQA 1URBA 4GTXA 3CMRA 3NKMA 2W5XA 3MK0A 1ZEBA 4N7TA 1ALHA 1ANIA 1EW2A 4FDIA 2W5VA 3MK1A 1E1ZP 3MK2A 5L0KA 3UNYA 3WAYA 4UOPA 5LIAA 3SZZA 5IJSA 3UN5A 4ZGAA 4KAVA 3IGZB 5L0BA 4MHXA 5L0EA 5HRTA 1B8JA 1EJJA 5C66A 5LQQA 5GOVA 4UPLA 2GA3A 3WAXA 1E33P 1EQJA 1P49A 3NKQA 3NKPA 5EGEA 1ELXA 1Y6VA 2GSOA 1URAA 4KJGA 4B56A 4CXUA 4CXSA 3NKOA 2W5TA 4MIVA 1E3CP 4TN0A 2W5WA 3WAWA 2G9YA 3TX0A 1O98A 3ED4A 3TG0A 1KH4A 4GTZA 2VQRA 1K7HA 2XRGA 3BDGB 1AUKA 4UPHA 4ZG6A 1KHNA 1HDHA 3M8YA 5GRRA 1KH9A 1KHKA 3A52A 1ZEDA 4CYSA 2W8SA 3WAVA 4MY4A 4LR7A 3KD8A 4LR2A 5LRMA 4LRBA 1AJDA 1KH7A 2IUCB 2QZUA 1ALIA 4GTYA 5DLVA 4LREA 3TWZA 5DLWA 5K4PA 1FSUA 2ANHA 2W5RA 1EW8A 3M7VA 1AJCA 4ZG9A 3Q3QA 4LR9A 4NWXA 4UPKA 3B5QA 1ANJA 4FDJA 2W5QA 3OT9A 3BDGA 4LR8A 3UN2A 4ZG7A 1AJBA 1AJAA 1EW9A 5IJQA 1KHJA 3E2DA 5AJ9A 2ZKTA 3DYCA 1E2SP 1N2KA 4QAXA 3SZYA 3M8ZA 4LRAA 2W8DA 2RH6A 5DLTA 3T02A 1O99A 3BDFA 3UO0A 4LQYA 5INHA 5EGHA 2IFYA 3NVLA 2W5SA 4UPIA 4CYRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T00 A;  4UOO A;  1ZEF A;  1ALK A;  4YR1 A;  3UN3 A;  1SHQ A;  1ELY A;  3NKN A;  4KAY A;  1KH5 A;  1Y7A A;  1SHN A;  4LRC A;  1ELZ A;  4UOR A;  3M8W A;  2GLQ A;  3NKR A;  5LRN A;  2D1G A;  3BDH A;  4LRF A;  1ED9 A;  3WBH A;  1ED8 A;  2X98 A;  2IUC A;  3IDD A;  1ALJ A;  1N2L A;  2GSU A;  3IGY B;  4NWJ A;  4CXK A;  2GSN A;  1HJK A;  4KJD A;  2XR9 A;  5TJ3 A;  1HQA A;  4LRD A;  5KXA A;  4GTW A;  3DPC A;  1EI6 A;  1KHL A;  3T01 A;  4KM4 A;  3LXQ A;  1URB A;  4GTX A;  3CMR A;  3NKM A;  2W5X A;  3MK0 A;  1ZEB A;  4N7T A;  1ALH A;  1ANI A;  1EW2 A;  4FDI A;  2W5V A;  3MK1 A;  1E1Z P;  3MK2 A;  5L0K A;  3UNY A;  3WAY A;  4UOP A;  5LIA A;  3SZZ A;  5IJS A;  3UN5 A;  4ZGA A;  4KAV A;  3IGZ B;  5L0B A;  4MHX A;  5L0E A;  5HRT A;  1B8J A;  1EJJ A;  5C66 A;  5LQQ A;  5GOV A;  4UPL A;  2GA3 A;  3WAX A;  1E33 P;  1EQJ A;  1P49 A;  3NKQ A;  3NKP A;  5EGE A;  1ELX A;  1Y6V A;  2GSO A;  1URA A;  4KJG A;  4B56 A;  4CXU A;  4CXS A;  3NKO A;  2W5T A;  4MIV A;  1E3C P;  4TN0 A;  2W5W A;  3WAW A;  2G9Y A;  3TX0 A;  1O98 A;  3ED4 A;  3TG0 A;  1KH4 A;  4GTZ A;  2VQR A;  1K7H A;  2XRG A;  3BDG B;  1AUK A;  4UPH A;  4ZG6 A;  1KHN A;  1HDH A;  3M8Y A;  5GRR A;  1KH9 A;  1KHK A;  3A52 A;  1ZED A;  4CYS A;  2W8S A;  3WAV A;  4MY4 A;  4LR7 A;  3KD8 A;  4LR2 A;  5LRM A;  4LRB A;  1AJD A;  1KH7 A;  2IUC B;  2QZU A;  1ALI A;  4GTY A;  5DLV A;  4LRE A;  3TWZ A;  5DLW A;  5K4P A;  1FSU A;  2ANH A;  2W5R A;  1EW8 A;  3M7V A;  1AJC A;  4ZG9 A;  3Q3Q A;  4LR9 A;  4NWX A;  4UPK A;  3B5Q A;  1ANJ A;  4FDJ A;  2W5Q A;  3OT9 A;  3BDG A;  4LR8 A;  3UN2 A;  4ZG7 A;  1AJB A;  1AJA A;  1EW9 A;  5IJQ A;  1KHJ A;  3E2D A;  5AJ9 A;  2ZKT A;  3DYC A;  1E2S P;  1N2K A;  4QAX A;  3SZY A;  3M8Z A;  4LRA A;  2W8D A;  2RH6 A;  5DLT A;  3T02 A;  1O99 A;  3BDF A;  3UO0 A;  4LQY A;  5INH A;  5EGH A;  2IFY A;  3NVL A;  2W5S A;  4UPI A;  4CYR A; 
#chains in the Genus database with same CATH topology
 3T00 A;  4UOO A;  1ZEF A;  1ALK A;  4YR1 A;  3UN3 A;  1SHQ A;  1ELY A;  3NKN A;  4KAY A;  1KH5 A;  1Y7A A;  1SHN A;  4LRC A;  1ELZ A;  4UOR A;  3M8W A;  2GLQ A;  3NKR A;  5LRN A;  2D1G A;  3BDH A;  4LRF A;  1ED9 A;  3WBH A;  1ED8 A;  2X98 A;  2IUC A;  3IDD A;  1ALJ A;  1N2L A;  2GSU A;  3IGY B;  4NWJ A;  4CXK A;  2GSN A;  1HJK A;  4KJD A;  2XR9 A;  5TJ3 A;  1HQA A;  4LRD A;  5KXA A;  4GTW A;  3DPC A;  1EI6 A;  1KHL A;  3T01 A;  4KM4 A;  3LXQ A;  1URB A;  4GTX A;  3CMR A;  3NKM A;  2W5X A;  3MK0 A;  1ZEB A;  4N7T A;  1ALH A;  1ANI A;  1EW2 A;  4FDI A;  2W5V A;  3MK1 A;  1E1Z P;  3MK2 A;  5L0K A;  3UNY A;  3WAY A;  4UOP A;  5LIA A;  3SZZ A;  5IJS A;  3UN5 A;  4ZGA A;  4KAV A;  3IGZ B;  5L0B A;  4MHX A;  5L0E A;  5HRT A;  1B8J A;  1EJJ A;  5C66 A;  5LQQ A;  5GOV A;  4UPL A;  2GA3 A;  3WAX A;  1E33 P;  1EQJ A;  1P49 A;  3NKQ A;  3NKP A;  5EGE A;  1ELX A;  1Y6V A;  2GSO A;  1URA A;  4KJG A;  4B56 A;  4CXU A;  4CXS A;  3NKO A;  2W5T A;  4MIV A;  1E3C P;  4TN0 A;  2W5W A;  3WAW A;  2G9Y A;  3TX0 A;  1O98 A;  3ED4 A;  3TG0 A;  1KH4 A;  4GTZ A;  2VQR A;  1K7H A;  2XRG A;  3BDG B;  1AUK A;  4UPH A;  4ZG6 A;  1KHN A;  1HDH A;  3M8Y A;  5GRR A;  1KH9 A;  1KHK A;  3A52 A;  1ZED A;  4CYS A;  2W8S A;  3WAV A;  4MY4 A;  4LR7 A;  3KD8 A;  4LR2 A;  5LRM A;  4LRB A;  1AJD A;  1KH7 A;  2IUC B;  2QZU A;  1ALI A;  4GTY A;  5DLV A;  4LRE A;  3TWZ A;  5DLW A;  5K4P A;  1FSU A;  2ANH A;  2W5R A;  1EW8 A;  3M7V A;  1AJC A;  4ZG9 A;  3Q3Q A;  4LR9 A;  4NWX A;  4UPK A;  3B5Q A;  1ANJ A;  4FDJ A;  2W5Q A;  3OT9 A;  3BDG A;  4LR8 A;  3UN2 A;  4ZG7 A;  1AJB A;  1AJA A;  1EW9 A;  5IJQ A;  1KHJ A;  3E2D A;  5AJ9 A;  2ZKT A;  3DYC A;  1E2S P;  1N2K A;  4QAX A;  3SZY A;  3M8Z A;  4LRA A;  2W8D A;  2RH6 A;  5DLT A;  3T02 A;  1O99 A;  3BDF A;  3UO0 A;  4LQY A;  5INH A;  5EGH A;  2IFY A;  3NVL A;  2W5S A;  4UPI A;  4CYR A; 
#chains in the Genus database with same CATH homology
 3T00 A;  4UOO A;  1ZEF A;  1ALK A;  4YR1 A;  3UN3 A;  1SHQ A;  1ELY A;  3NKN A;  4KAY A;  1KH5 A;  1Y7A A;  1SHN A;  4LRC A;  1ELZ A;  4UOR A;  3M8W A;  2GLQ A;  3NKR A;  5LRN A;  2D1G A;  3BDH A;  4LRF A;  1ED9 A;  3WBH A;  1ED8 A;  2X98 A;  2IUC A;  3IDD A;  1ALJ A;  1N2L A;  2GSU A;  3IGY B;  4NWJ A;  4CXK A;  2GSN A;  1HJK A;  4KJD A;  2XR9 A;  5TJ3 A;  1HQA A;  4LRD A;  5KXA A;  4GTW A;  3DPC A;  1EI6 A;  1KHL A;  3T01 A;  4KM4 A;  3LXQ A;  1URB A;  4GTX A;  3CMR A;  3NKM A;  2W5X A;  3MK0 A;  1ZEB A;  4N7T A;  1ALH A;  1ANI A;  1EW2 A;  4FDI A;  2W5V A;  3MK1 A;  1E1Z P;  3MK2 A;  5L0K A;  3UNY A;  3WAY A;  4UOP A;  5LIA A;  3SZZ A;  5IJS A;  3UN5 A;  4ZGA A;  4KAV A;  3IGZ B;  5L0B A;  4MHX A;  5L0E A;  5HRT A;  1B8J A;  1EJJ A;  5C66 A;  5LQQ A;  5GOV A;  4UPL A;  2GA3 A;  3WAX A;  1E33 P;  1EQJ A;  1P49 A;  3NKQ A;  3NKP A;  5EGE A;  1ELX A;  1Y6V A;  2GSO A;  1URA A;  4KJG A;  4B56 A;  4CXU A;  4CXS A;  3NKO A;  2W5T A;  4MIV A;  1E3C P;  4TN0 A;  2W5W A;  3WAW A;  2G9Y A;  3TX0 A;  1O98 A;  3ED4 A;  3TG0 A;  1KH4 A;  4GTZ A;  2VQR A;  1K7H A;  2XRG A;  3BDG B;  1AUK A;  4UPH A;  4ZG6 A;  1KHN A;  1HDH A;  3M8Y A;  5GRR A;  1KH9 A;  1KHK A;  3A52 A;  1ZED A;  4CYS A;  2W8S A;  3WAV A;  4MY4 A;  4LR7 A;  3KD8 A;  4LR2 A;  5LRM A;  4LRB A;  1AJD A;  1KH7 A;  2IUC B;  2QZU A;  1ALI A;  4GTY A;  5DLV A;  4LRE A;  3TWZ A;  5DLW A;  5K4P A;  1FSU A;  2ANH A;  2W5R A;  1EW8 A;  3M7V A;  1AJC A;  4ZG9 A;  3Q3Q A;  4LR9 A;  4NWX A;  4UPK A;  3B5Q A;  1ANJ A;  4FDJ A;  2W5Q A;  3OT9 A;  3BDG A;  4LR8 A;  3UN2 A;  4ZG7 A;  1AJB A;  1AJA A;  1EW9 A;  5IJQ A;  1KHJ A;  3E2D A;  5AJ9 A;  2ZKT A;  3DYC A;  1E2S P;  1N2K A;  4QAX A;  3SZY A;  3M8Z A;  4LRA A;  2W8D A;  2RH6 A;  5DLT A;  3T02 A;  1O99 A;  3BDF A;  3UO0 A;  4LQY A;  5INH A;  5EGH A;  2IFY A;  3NVL A;  2W5S A;  4UPI A;  4CYR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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