1KHLA

E. coli alkaline phosphatase mutant (d153hd330n) complex with phosphate
Total Genus 150
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
150
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Alkaline Phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 150
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khlA00
3LXQA 3BDHA 4ZG9A 2X98A 3A52A 4KAVA 1AJAA 3NKQA 4UPHA 1KH5A 4MHXA 5K4PA 3MK2A 3NKNA 3UO0A 4LRCA 1EW2A 3KD8A 4KJGA 5IJQA 2W8SA 1EW8A 3Q3QA 3UN5A 1ELXA 3IGZB 4UORA 2W5TA 3M8YA 4GTWA 3UNYA 5IJSA 5LRMA 2W5SA 1EW9A 1KHNA 2W5VA 4MIVA 3WAVA 2IUCA 2GA3A 2GSOA 4KJDA 1URBA 1N2KA 5DLVA 4LRBA 5L0BA 4GTXA 4LR9A 2RH6A 2GSNA 4LRFA 4NWJA 1ALJA 3TX0A 1KH7A 1O99A 2W8DA 3MK0A 4UOPA 3B5QA 5TJ3A 3TWZA 1ELYA 1AJBA 1E3CP 2ZKTA 1Y6VA 2W5RA 1KH4A 4NWXA 3SZYA 3BDFA 4UPKA 3DPCA 5EGHA 1HJKA 5LQQA 1Y7AA 5GOVA 4LR7A 3MK1A 1URAA 3T00A 4CXUA 4ZGAA 3M8ZA 3T02A 4LR2A 5HRTA 1HDHA 1O98A 4UOOA 1KHJA 1KHLA 1KH9A 4UPIA 1ZEDA 4LREA 1ANIA 2ANHA 4KM4A 1EQJA 2G9YA 5LRNA 1K7HA 3NVLA 1AUKA 4MY4A 5DLTA 1EJJA 4UPLA 3WAXA 1ALHA 3T01A 1FSUA 3M8WA 5L0KA 1ED9A 1HQAA 3BDGB 4LQYA 3UN2A 1E2SP 5DLWA 1N2LA 2GSUA 4ZG6A 3IDDA 3E2DA 1ALIA 4GTZA 2W5XA 3NKMA 5GRRA 3M7VA 2IUCB 1E1ZP 4TN0A 4YR1A 4LRAA 1P49A 1SHQA 4LRDA 1B8JA 3IGYB 4FDJA 3OT9A 1EI6A 4LR8A 3NKPA 3TG0A 2IFYA 4CXSA 5L0EA 5C66A 3NKRA 5EGEA 2GLQA 2W5WA 2QZUA 3WBHA 3SZZA 3UN3A 1ZEFA 4N7TA 3NKOA 2VQRA 1ELZA 5KXAA 4KAYA 1SHNA 2D1GA 3ED4A 1E33P 4CYRA 3WAWA 3BDGA 2W5QA 5INHA 2XR9A 1ED8A 1ALKA 2XRGA 4CXKA 4ZG7A 4B56A 4GTYA 4QAXA 3CMRA 3WAYA 1AJCA 1ZEBA 5AJ9A 1KHKA 4CYSA 3DYCA 5LIAA 4FDIA 1ANJA 1AJDA
chains in the Genus database with same CATH superfamily
3LXQA 3BDHA 4ZG9A 2X98A 3A52A 4KAVA 1AJAA 3NKQA 4UPHA 1KH5A 4MHXA 5K4PA 3MK2A 3NKNA 3UO0A 4LRCA 1EW2A 3KD8A 4KJGA 5IJQA 2W8SA 1EW8A 3Q3QA 3UN5A 1ELXA 3IGZB 4UORA 2W5TA 3M8YA 4GTWA 3UNYA 5IJSA 5LRMA 2W5SA 1EW9A 1KHNA 2W5VA 4MIVA 3WAVA 2IUCA 2GA3A 2GSOA 4KJDA 1URBA 1N2KA 5DLVA 4LRBA 5L0BA 4GTXA 4LR9A 2RH6A 2GSNA 4LRFA 4NWJA 1ALJA 3TX0A 1KH7A 1O99A 2W8DA 3MK0A 4UOPA 3B5QA 5TJ3A 3TWZA 1ELYA 1AJBA 1E3CP 2ZKTA 1Y6VA 2W5RA 1KH4A 4NWXA 3SZYA 3BDFA 4UPKA 3DPCA 5EGHA 1HJKA 5LQQA 1Y7AA 5GOVA 4LR7A 3MK1A 1URAA 3T00A 4CXUA 4ZGAA 3M8ZA 3T02A 4LR2A 5HRTA 1HDHA 1O98A 4UOOA 1KHJA 1KHLA 1KH9A 4UPIA 1ZEDA 4LREA 1ANIA 2ANHA 4KM4A 1EQJA 2G9YA 5LRNA 1K7HA 3NVLA 1AUKA 4MY4A 5DLTA 1EJJA 4UPLA 3WAXA 1ALHA 3T01A 1FSUA 3M8WA 5L0KA 1ED9A 1HQAA 3BDGB 4LQYA 3UN2A 1E2SP 5DLWA 1N2LA 2GSUA 4ZG6A 3IDDA 3E2DA 1ALIA 4GTZA 2W5XA 3NKMA 5GRRA 3M7VA 2IUCB 1E1ZP 4TN0A 4YR1A 4LRAA 1P49A 1SHQA 4LRDA 1B8JA 3IGYB 4FDJA 3OT9A 1EI6A 4LR8A 3NKPA 3TG0A 2IFYA 4CXSA 5L0EA 5C66A 3NKRA 5EGEA 2GLQA 2W5WA 2QZUA 3WBHA 3SZZA 3UN3A 1ZEFA 4N7TA 3NKOA 2VQRA 1ELZA 5KXAA 4KAYA 1SHNA 2D1GA 3ED4A 1E33P 4CYRA 3WAWA 3BDGA 2W5QA 5INHA 2XR9A 1ED8A 1ALKA 2XRGA 4CXKA 4ZG7A 4B56A 4GTYA 4QAXA 3CMRA 3WAYA 1AJCA 1ZEBA 5AJ9A 1KHKA 4CYSA 3DYCA 5LIAA 4FDIA 1ANJA 1AJDA
chains in the Genus database with same CATH topology
3LXQA 3BDHA 4ZG9A 2X98A 3A52A 4KAVA 1AJAA 3NKQA 4UPHA 1KH5A 4MHXA 5K4PA 3MK2A 3NKNA 3UO0A 4LRCA 1EW2A 3KD8A 4KJGA 5IJQA 2W8SA 1EW8A 3Q3QA 3UN5A 1ELXA 3IGZB 4UORA 2W5TA 3M8YA 4GTWA 3UNYA 5IJSA 5LRMA 2W5SA 1EW9A 1KHNA 2W5VA 4MIVA 3WAVA 2IUCA 2GA3A 2GSOA 4KJDA 1URBA 1N2KA 5DLVA 4LRBA 5L0BA 4GTXA 4LR9A 2RH6A 2GSNA 4LRFA 4NWJA 1ALJA 3TX0A 1KH7A 1O99A 2W8DA 3MK0A 4UOPA 3B5QA 5TJ3A 3TWZA 1ELYA 1AJBA 1E3CP 2ZKTA 1Y6VA 2W5RA 1KH4A 4NWXA 3SZYA 3BDFA 4UPKA 3DPCA 5EGHA 1HJKA 5LQQA 1Y7AA 5GOVA 4LR7A 3MK1A 1URAA 3T00A 4CXUA 4ZGAA 3M8ZA 3T02A 4LR2A 5HRTA 1HDHA 1O98A 4UOOA 1KHJA 1KHLA 1KH9A 4UPIA 1ZEDA 4LREA 1ANIA 2ANHA 4KM4A 1EQJA 2G9YA 5LRNA 1K7HA 3NVLA 1AUKA 4MY4A 5DLTA 1EJJA 4UPLA 3WAXA 1ALHA 3T01A 1FSUA 3M8WA 5L0KA 1ED9A 1HQAA 3BDGB 4LQYA 3UN2A 1E2SP 5DLWA 1N2LA 2GSUA 4ZG6A 3IDDA 3E2DA 1ALIA 4GTZA 2W5XA 3NKMA 5GRRA 3M7VA 2IUCB 1E1ZP 4TN0A 4YR1A 4LRAA 1P49A 1SHQA 4LRDA 1B8JA 3IGYB 4FDJA 3OT9A 1EI6A 4LR8A 3NKPA 3TG0A 2IFYA 4CXSA 5L0EA 5C66A 3NKRA 5EGEA 2GLQA 2W5WA 2QZUA 3WBHA 3SZZA 3UN3A 1ZEFA 4N7TA 3NKOA 2VQRA 1ELZA 5KXAA 4KAYA 1SHNA 2D1GA 3ED4A 1E33P 4CYRA 3WAWA 3BDGA 2W5QA 5INHA 2XR9A 1ED8A 1ALKA 2XRGA 4CXKA 4ZG7A 4B56A 4GTYA 4QAXA 3CMRA 3WAYA 1AJCA 1ZEBA 5AJ9A 1KHKA 4CYSA 3DYCA 5LIAA 4FDIA 1ANJA 1AJDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LXQ A;  3BDH A;  4ZG9 A;  2X98 A;  3A52 A;  4KAV A;  1AJA A;  3NKQ A;  4UPH A;  1KH5 A;  4MHX A;  5K4P A;  3MK2 A;  3NKN A;  3UO0 A;  4LRC A;  1EW2 A;  3KD8 A;  4KJG A;  5IJQ A;  2W8S A;  1EW8 A;  3Q3Q A;  3UN5 A;  1ELX A;  3IGZ B;  4UOR A;  2W5T A;  3M8Y A;  4GTW A;  3UNY A;  5IJS A;  5LRM A;  2W5S A;  1EW9 A;  1KHN A;  2W5V A;  4MIV A;  3WAV A;  2IUC A;  2GA3 A;  2GSO A;  4KJD A;  1URB A;  1N2K A;  5DLV A;  4LRB A;  5L0B A;  4GTX A;  4LR9 A;  2RH6 A;  2GSN A;  4LRF A;  4NWJ A;  1ALJ A;  3TX0 A;  1KH7 A;  1O99 A;  2W8D A;  3MK0 A;  4UOP A;  3B5Q A;  5TJ3 A;  3TWZ A;  1ELY A;  1AJB A;  1E3C P;  2ZKT A;  1Y6V A;  2W5R A;  1KH4 A;  4NWX A;  3SZY A;  3BDF A;  4UPK A;  3DPC A;  5EGH A;  1HJK A;  5LQQ A;  1Y7A A;  5GOV A;  4LR7 A;  3MK1 A;  1URA A;  3T00 A;  4CXU A;  4ZGA A;  3M8Z A;  3T02 A;  4LR2 A;  5HRT A;  1HDH A;  1O98 A;  4UOO A;  1KHJ A;  1KHL A;  1KH9 A;  4UPI A;  1ZED A;  4LRE A;  1ANI A;  2ANH A;  4KM4 A;  1EQJ A;  2G9Y A;  5LRN A;  1K7H A;  3NVL A;  1AUK A;  4MY4 A;  5DLT A;  1EJJ A;  4UPL A;  3WAX A;  1ALH A;  3T01 A;  1FSU A;  3M8W A;  5L0K A;  1ED9 A;  1HQA A;  3BDG B;  4LQY A;  3UN2 A;  1E2S P;  5DLW A;  1N2L A;  2GSU A;  4ZG6 A;  3IDD A;  3E2D A;  1ALI A;  4GTZ A;  2W5X A;  3NKM A;  5GRR A;  3M7V A;  2IUC B;  1E1Z P;  4TN0 A;  4YR1 A;  4LRA A;  1P49 A;  1SHQ A;  4LRD A;  1B8J A;  3IGY B;  4FDJ A;  3OT9 A;  1EI6 A;  4LR8 A;  3NKP A;  3TG0 A;  2IFY A;  4CXS A;  5L0E A;  5C66 A;  3NKR A;  5EGE A;  2GLQ A;  2W5W A;  2QZU A;  3WBH A;  3SZZ A;  3UN3 A;  1ZEF A;  4N7T A;  3NKO A;  2VQR A;  1ELZ A;  5KXA A;  4KAY A;  1SHN A;  2D1G A;  3ED4 A;  1E33 P;  4CYR A;  3WAW A;  3BDG A;  2W5Q A;  5INH A;  2XR9 A;  1ED8 A;  1ALK A;  2XRG A;  4CXK A;  4ZG7 A;  4B56 A;  4GTY A;  4QAX A;  3CMR A;  3WAY A;  1AJC A;  1ZEB A;  5AJ9 A;  1KHK A;  4CYS A;  3DYC A;  5LIA A;  4FDI A;  1ANJ A;  1AJD A; 
#chains in the Genus database with same CATH topology
 3LXQ A;  3BDH A;  4ZG9 A;  2X98 A;  3A52 A;  4KAV A;  1AJA A;  3NKQ A;  4UPH A;  1KH5 A;  4MHX A;  5K4P A;  3MK2 A;  3NKN A;  3UO0 A;  4LRC A;  1EW2 A;  3KD8 A;  4KJG A;  5IJQ A;  2W8S A;  1EW8 A;  3Q3Q A;  3UN5 A;  1ELX A;  3IGZ B;  4UOR A;  2W5T A;  3M8Y A;  4GTW A;  3UNY A;  5IJS A;  5LRM A;  2W5S A;  1EW9 A;  1KHN A;  2W5V A;  4MIV A;  3WAV A;  2IUC A;  2GA3 A;  2GSO A;  4KJD A;  1URB A;  1N2K A;  5DLV A;  4LRB A;  5L0B A;  4GTX A;  4LR9 A;  2RH6 A;  2GSN A;  4LRF A;  4NWJ A;  1ALJ A;  3TX0 A;  1KH7 A;  1O99 A;  2W8D A;  3MK0 A;  4UOP A;  3B5Q A;  5TJ3 A;  3TWZ A;  1ELY A;  1AJB A;  1E3C P;  2ZKT A;  1Y6V A;  2W5R A;  1KH4 A;  4NWX A;  3SZY A;  3BDF A;  4UPK A;  3DPC A;  5EGH A;  1HJK A;  5LQQ A;  1Y7A A;  5GOV A;  4LR7 A;  3MK1 A;  1URA A;  3T00 A;  4CXU A;  4ZGA A;  3M8Z A;  3T02 A;  4LR2 A;  5HRT A;  1HDH A;  1O98 A;  4UOO A;  1KHJ A;  1KHL A;  1KH9 A;  4UPI A;  1ZED A;  4LRE A;  1ANI A;  2ANH A;  4KM4 A;  1EQJ A;  2G9Y A;  5LRN A;  1K7H A;  3NVL A;  1AUK A;  4MY4 A;  5DLT A;  1EJJ A;  4UPL A;  3WAX A;  1ALH A;  3T01 A;  1FSU A;  3M8W A;  5L0K A;  1ED9 A;  1HQA A;  3BDG B;  4LQY A;  3UN2 A;  1E2S P;  5DLW A;  1N2L A;  2GSU A;  4ZG6 A;  3IDD A;  3E2D A;  1ALI A;  4GTZ A;  2W5X A;  3NKM A;  5GRR A;  3M7V A;  2IUC B;  1E1Z P;  4TN0 A;  4YR1 A;  4LRA A;  1P49 A;  1SHQ A;  4LRD A;  1B8J A;  3IGY B;  4FDJ A;  3OT9 A;  1EI6 A;  4LR8 A;  3NKP A;  3TG0 A;  2IFY A;  4CXS A;  5L0E A;  5C66 A;  3NKR A;  5EGE A;  2GLQ A;  2W5W A;  2QZU A;  3WBH A;  3SZZ A;  3UN3 A;  1ZEF A;  4N7T A;  3NKO A;  2VQR A;  1ELZ A;  5KXA A;  4KAY A;  1SHN A;  2D1G A;  3ED4 A;  1E33 P;  4CYR A;  3WAW A;  3BDG A;  2W5Q A;  5INH A;  2XR9 A;  1ED8 A;  1ALK A;  2XRG A;  4CXK A;  4ZG7 A;  4B56 A;  4GTY A;  4QAX A;  3CMR A;  3WAY A;  1AJC A;  1ZEB A;  5AJ9 A;  1KHK A;  4CYS A;  3DYC A;  5LIA A;  4FDI A;  1ANJ A;  1AJD A; 
#chains in the Genus database with same CATH homology
 3LXQ A;  3BDH A;  4ZG9 A;  2X98 A;  3A52 A;  4KAV A;  1AJA A;  3NKQ A;  4UPH A;  1KH5 A;  4MHX A;  5K4P A;  3MK2 A;  3NKN A;  3UO0 A;  4LRC A;  1EW2 A;  3KD8 A;  4KJG A;  5IJQ A;  2W8S A;  1EW8 A;  3Q3Q A;  3UN5 A;  1ELX A;  3IGZ B;  4UOR A;  2W5T A;  3M8Y A;  4GTW A;  3UNY A;  5IJS A;  5LRM A;  2W5S A;  1EW9 A;  1KHN A;  2W5V A;  4MIV A;  3WAV A;  2IUC A;  2GA3 A;  2GSO A;  4KJD A;  1URB A;  1N2K A;  5DLV A;  4LRB A;  5L0B A;  4GTX A;  4LR9 A;  2RH6 A;  2GSN A;  4LRF A;  4NWJ A;  1ALJ A;  3TX0 A;  1KH7 A;  1O99 A;  2W8D A;  3MK0 A;  4UOP A;  3B5Q A;  5TJ3 A;  3TWZ A;  1ELY A;  1AJB A;  1E3C P;  2ZKT A;  1Y6V A;  2W5R A;  1KH4 A;  4NWX A;  3SZY A;  3BDF A;  4UPK A;  3DPC A;  5EGH A;  1HJK A;  5LQQ A;  1Y7A A;  5GOV A;  4LR7 A;  3MK1 A;  1URA A;  3T00 A;  4CXU A;  4ZGA A;  3M8Z A;  3T02 A;  4LR2 A;  5HRT A;  1HDH A;  1O98 A;  4UOO A;  1KHJ A;  1KHL A;  1KH9 A;  4UPI A;  1ZED A;  4LRE A;  1ANI A;  2ANH A;  4KM4 A;  1EQJ A;  2G9Y A;  5LRN A;  1K7H A;  3NVL A;  1AUK A;  4MY4 A;  5DLT A;  1EJJ A;  4UPL A;  3WAX A;  1ALH A;  3T01 A;  1FSU A;  3M8W A;  5L0K A;  1ED9 A;  1HQA A;  3BDG B;  4LQY A;  3UN2 A;  1E2S P;  5DLW A;  1N2L A;  2GSU A;  4ZG6 A;  3IDD A;  3E2D A;  1ALI A;  4GTZ A;  2W5X A;  3NKM A;  5GRR A;  3M7V A;  2IUC B;  1E1Z P;  4TN0 A;  4YR1 A;  4LRA A;  1P49 A;  1SHQ A;  4LRD A;  1B8J A;  3IGY B;  4FDJ A;  3OT9 A;  1EI6 A;  4LR8 A;  3NKP A;  3TG0 A;  2IFY A;  4CXS A;  5L0E A;  5C66 A;  3NKR A;  5EGE A;  2GLQ A;  2W5W A;  2QZU A;  3WBH A;  3SZZ A;  3UN3 A;  1ZEF A;  4N7T A;  3NKO A;  2VQR A;  1ELZ A;  5KXA A;  4KAY A;  1SHN A;  2D1G A;  3ED4 A;  1E33 P;  4CYR A;  3WAW A;  3BDG A;  2W5Q A;  5INH A;  2XR9 A;  1ED8 A;  1ALK A;  2XRG A;  4CXK A;  4ZG7 A;  4B56 A;  4GTY A;  4QAX A;  3CMR A;  3WAY A;  1AJC A;  1ZEB A;  5AJ9 A;  1KHK A;  4CYS A;  3DYC A;  5LIA A;  4FDI A;  1ANJ A;  1AJD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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