1KHJA

E. coli alkaline phosphatase mutant (d153hd330n) mimic of the transition states with aluminium fluoride
Total Genus 156
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 156
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khjA00
2GSNA 3UN3A 4LRCA 5L0BA 1O98A 2G9YA 3WAVA 4UORA 4YR1A 4CXKA 4UOPA 2IUCA 4CYSA 3MK0A 5GRRA 1KHLA 1ZEFA 4FDJA 1KHKA 1EJJA 2GA3A 3NKPA 3T01A 5IJSA 5L0KA 1AJBA 3M8YA 4ZG7A 4CXSA 3NKNA 1KH5A 4MHXA 1ALIA 3B5QA 1E2SP 3BDFA 1SHQA 3KD8A 1B8JA 3BDGA 5KXAA 2W5SA 4QAXA 3CMRA 1ANJA 4UPLA 3E2DA 4KJDA 4FDIA 3M8WA 3WAXA 3BDHA 2XR9A 1ED9A 2IUCB 4LQYA 1EW2A 2ZKTA 4ZG9A 5HRTA 3DYCA 3M8ZA 2VQRA 4UPKA 1EQJA 4MIVA 4NWXA 5L0EA 4ZG6A 3BDGB 1AUKA 1ELZA 1HJKA 3Q3QA 3SZZA 1ED8A 3TX0A 3UO0A 2ANHA 4LREA 5K4PA 4UPHA 1Y7AA 2W5RA 3NVLA 3WBHA 2W8DA 1E33P 4LRFA 3NKRA 4LR7A 4LRBA 3UN2A 4LR8A 5LRMA 2IFYA 4GTZA 1P49A 3T00A 1EI6A 4GTWA 4LR2A 1K7HA 2W5QA 2GLQA 3UNYA 1ANIA 1ALKA 4CXUA 1URAA 3LXQA 4KM4A 5EGHA 2W8SA 5LRNA 1KH9A 1N2KA 1AJDA 5DLTA 5TJ3A 4UOOA 3IGZB 2W5TA 1N2LA 1EW9A 1HQAA 3IDDA 2GSUA 4TN0A 4UPIA 5DLWA 2W5WA 4ZGAA 1URBA 5LIAA 4LRDA 5INHA 1ALJA 1ALHA 1E1ZP 4KJGA 2W5VA 3UN5A 4LRAA 1ZEBA 1O99A 3MK1A 4GTYA 4N7TA 1KH4A 1KH7A 4B56A 1SHNA 2D1GA 3A52A 1Y6VA 3NKMA 3ED4A 1ZEDA 3NKQA 3NKOA 2XRGA 4CYRA 1KHNA 3SZYA 1AJCA 1E3CP 2GSOA 1FSUA 3WAYA 4NWJA 2RH6A 2W5XA 5LQQA 4LR9A 5IJQA 1KHJA 3TG0A 1ELXA 4KAVA 1EW8A 1ELYA 3M7VA 2QZUA 3OT9A 2X98A 3DPCA 3MK2A 1AJAA 1HDHA 3TWZA 4MY4A 3IGYB 3WAWA 5AJ9A 5GOVA 3T02A 4KAYA 5DLVA 5C66A 5EGEA 4GTXA
chains in the Genus database with same CATH superfamily
2GSNA 3UN3A 4LRCA 5L0BA 1O98A 2G9YA 3WAVA 4UORA 4YR1A 4CXKA 4UOPA 2IUCA 4CYSA 3MK0A 5GRRA 1KHLA 1ZEFA 4FDJA 1KHKA 1EJJA 2GA3A 3NKPA 3T01A 5IJSA 5L0KA 1AJBA 3M8YA 4ZG7A 4CXSA 3NKNA 1KH5A 4MHXA 1ALIA 3B5QA 1E2SP 3BDFA 1SHQA 3KD8A 1B8JA 3BDGA 5KXAA 2W5SA 4QAXA 3CMRA 1ANJA 4UPLA 3E2DA 4KJDA 4FDIA 3M8WA 3WAXA 3BDHA 2XR9A 1ED9A 2IUCB 4LQYA 1EW2A 2ZKTA 4ZG9A 5HRTA 3DYCA 3M8ZA 2VQRA 4UPKA 1EQJA 4MIVA 4NWXA 5L0EA 4ZG6A 3BDGB 1AUKA 1ELZA 1HJKA 3Q3QA 3SZZA 1ED8A 3TX0A 3UO0A 2ANHA 4LREA 5K4PA 4UPHA 1Y7AA 2W5RA 3NVLA 3WBHA 2W8DA 1E33P 4LRFA 3NKRA 4LR7A 4LRBA 3UN2A 4LR8A 5LRMA 2IFYA 4GTZA 1P49A 3T00A 1EI6A 4GTWA 4LR2A 1K7HA 2W5QA 2GLQA 3UNYA 1ANIA 1ALKA 4CXUA 1URAA 3LXQA 4KM4A 5EGHA 2W8SA 5LRNA 1KH9A 1N2KA 1AJDA 5DLTA 5TJ3A 4UOOA 3IGZB 2W5TA 1N2LA 1EW9A 1HQAA 3IDDA 2GSUA 4TN0A 4UPIA 5DLWA 2W5WA 4ZGAA 1URBA 5LIAA 4LRDA 5INHA 1ALJA 1ALHA 1E1ZP 4KJGA 2W5VA 3UN5A 4LRAA 1ZEBA 1O99A 3MK1A 4GTYA 4N7TA 1KH4A 1KH7A 4B56A 1SHNA 2D1GA 3A52A 1Y6VA 3NKMA 3ED4A 1ZEDA 3NKQA 3NKOA 2XRGA 4CYRA 1KHNA 3SZYA 1AJCA 1E3CP 2GSOA 1FSUA 3WAYA 4NWJA 2RH6A 2W5XA 5LQQA 4LR9A 5IJQA 1KHJA 3TG0A 1ELXA 4KAVA 1EW8A 1ELYA 3M7VA 2QZUA 3OT9A 2X98A 3DPCA 3MK2A 1AJAA 1HDHA 3TWZA 4MY4A 3IGYB 3WAWA 5AJ9A 5GOVA 3T02A 4KAYA 5DLVA 5C66A 5EGEA 4GTXA
chains in the Genus database with same CATH topology
2GSNA 3UN3A 4LRCA 5L0BA 1O98A 2G9YA 3WAVA 4UORA 4YR1A 4CXKA 4UOPA 2IUCA 4CYSA 3MK0A 5GRRA 1KHLA 1ZEFA 4FDJA 1KHKA 1EJJA 2GA3A 3NKPA 3T01A 5IJSA 5L0KA 1AJBA 3M8YA 4ZG7A 4CXSA 3NKNA 1KH5A 4MHXA 1ALIA 3B5QA 1E2SP 3BDFA 1SHQA 3KD8A 1B8JA 3BDGA 5KXAA 2W5SA 4QAXA 3CMRA 1ANJA 4UPLA 3E2DA 4KJDA 4FDIA 3M8WA 3WAXA 3BDHA 2XR9A 1ED9A 2IUCB 4LQYA 1EW2A 2ZKTA 4ZG9A 5HRTA 3DYCA 3M8ZA 2VQRA 4UPKA 1EQJA 4MIVA 4NWXA 5L0EA 4ZG6A 3BDGB 1AUKA 1ELZA 1HJKA 3Q3QA 3SZZA 1ED8A 3TX0A 3UO0A 2ANHA 4LREA 5K4PA 4UPHA 1Y7AA 2W5RA 3NVLA 3WBHA 2W8DA 1E33P 4LRFA 3NKRA 4LR7A 4LRBA 3UN2A 4LR8A 5LRMA 2IFYA 4GTZA 1P49A 3T00A 1EI6A 4GTWA 4LR2A 1K7HA 2W5QA 2GLQA 3UNYA 1ANIA 1ALKA 4CXUA 1URAA 3LXQA 4KM4A 5EGHA 2W8SA 5LRNA 1KH9A 1N2KA 1AJDA 5DLTA 5TJ3A 4UOOA 3IGZB 2W5TA 1N2LA 1EW9A 1HQAA 3IDDA 2GSUA 4TN0A 4UPIA 5DLWA 2W5WA 4ZGAA 1URBA 5LIAA 4LRDA 5INHA 1ALJA 1ALHA 1E1ZP 4KJGA 2W5VA 3UN5A 4LRAA 1ZEBA 1O99A 3MK1A 4GTYA 4N7TA 1KH4A 1KH7A 4B56A 1SHNA 2D1GA 3A52A 1Y6VA 3NKMA 3ED4A 1ZEDA 3NKQA 3NKOA 2XRGA 4CYRA 1KHNA 3SZYA 1AJCA 1E3CP 2GSOA 1FSUA 3WAYA 4NWJA 2RH6A 2W5XA 5LQQA 4LR9A 5IJQA 1KHJA 3TG0A 1ELXA 4KAVA 1EW8A 1ELYA 3M7VA 2QZUA 3OT9A 2X98A 3DPCA 3MK2A 1AJAA 1HDHA 3TWZA 4MY4A 3IGYB 3WAWA 5AJ9A 5GOVA 3T02A 4KAYA 5DLVA 5C66A 5EGEA 4GTXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GSN A;  3UN3 A;  4LRC A;  5L0B A;  1O98 A;  2G9Y A;  3WAV A;  4UOR A;  4YR1 A;  4CXK A;  4UOP A;  2IUC A;  4CYS A;  3MK0 A;  5GRR A;  1KHL A;  1ZEF A;  4FDJ A;  1KHK A;  1EJJ A;  2GA3 A;  3NKP A;  3T01 A;  5IJS A;  5L0K A;  1AJB A;  3M8Y A;  4ZG7 A;  4CXS A;  3NKN A;  1KH5 A;  4MHX A;  1ALI A;  3B5Q A;  1E2S P;  3BDF A;  1SHQ A;  3KD8 A;  1B8J A;  3BDG A;  5KXA A;  2W5S A;  4QAX A;  3CMR A;  1ANJ A;  4UPL A;  3E2D A;  4KJD A;  4FDI A;  3M8W A;  3WAX A;  3BDH A;  2XR9 A;  1ED9 A;  2IUC B;  4LQY A;  1EW2 A;  2ZKT A;  4ZG9 A;  5HRT A;  3DYC A;  3M8Z A;  2VQR A;  4UPK A;  1EQJ A;  4MIV A;  4NWX A;  5L0E A;  4ZG6 A;  3BDG B;  1AUK A;  1ELZ A;  1HJK A;  3Q3Q A;  3SZZ A;  1ED8 A;  3TX0 A;  3UO0 A;  2ANH A;  4LRE A;  5K4P A;  4UPH A;  1Y7A A;  2W5R A;  3NVL A;  3WBH A;  2W8D A;  1E33 P;  4LRF A;  3NKR A;  4LR7 A;  4LRB A;  3UN2 A;  4LR8 A;  5LRM A;  2IFY A;  4GTZ A;  1P49 A;  3T00 A;  1EI6 A;  4GTW A;  4LR2 A;  1K7H A;  2W5Q A;  2GLQ A;  3UNY A;  1ANI A;  1ALK A;  4CXU A;  1URA A;  3LXQ A;  4KM4 A;  5EGH A;  2W8S A;  5LRN A;  1KH9 A;  1N2K A;  1AJD A;  5DLT A;  5TJ3 A;  4UOO A;  3IGZ B;  2W5T A;  1N2L A;  1EW9 A;  1HQA A;  3IDD A;  2GSU A;  4TN0 A;  4UPI A;  5DLW A;  2W5W A;  4ZGA A;  1URB A;  5LIA A;  4LRD A;  5INH A;  1ALJ A;  1ALH A;  1E1Z P;  4KJG A;  2W5V A;  3UN5 A;  4LRA A;  1ZEB A;  1O99 A;  3MK1 A;  4GTY A;  4N7T A;  1KH4 A;  1KH7 A;  4B56 A;  1SHN A;  2D1G A;  3A52 A;  1Y6V A;  3NKM A;  3ED4 A;  1ZED A;  3NKQ A;  3NKO A;  2XRG A;  4CYR A;  1KHN A;  3SZY A;  1AJC A;  1E3C P;  2GSO A;  1FSU A;  3WAY A;  4NWJ A;  2RH6 A;  2W5X A;  5LQQ A;  4LR9 A;  5IJQ A;  1KHJ A;  3TG0 A;  1ELX A;  4KAV A;  1EW8 A;  1ELY A;  3M7V A;  2QZU A;  3OT9 A;  2X98 A;  3DPC A;  3MK2 A;  1AJA A;  1HDH A;  3TWZ A;  4MY4 A;  3IGY B;  3WAW A;  5AJ9 A;  5GOV A;  3T02 A;  4KAY A;  5DLV A;  5C66 A;  5EGE A;  4GTX A; 
#chains in the Genus database with same CATH topology
 2GSN A;  3UN3 A;  4LRC A;  5L0B A;  1O98 A;  2G9Y A;  3WAV A;  4UOR A;  4YR1 A;  4CXK A;  4UOP A;  2IUC A;  4CYS A;  3MK0 A;  5GRR A;  1KHL A;  1ZEF A;  4FDJ A;  1KHK A;  1EJJ A;  2GA3 A;  3NKP A;  3T01 A;  5IJS A;  5L0K A;  1AJB A;  3M8Y A;  4ZG7 A;  4CXS A;  3NKN A;  1KH5 A;  4MHX A;  1ALI A;  3B5Q A;  1E2S P;  3BDF A;  1SHQ A;  3KD8 A;  1B8J A;  3BDG A;  5KXA A;  2W5S A;  4QAX A;  3CMR A;  1ANJ A;  4UPL A;  3E2D A;  4KJD A;  4FDI A;  3M8W A;  3WAX A;  3BDH A;  2XR9 A;  1ED9 A;  2IUC B;  4LQY A;  1EW2 A;  2ZKT A;  4ZG9 A;  5HRT A;  3DYC A;  3M8Z A;  2VQR A;  4UPK A;  1EQJ A;  4MIV A;  4NWX A;  5L0E A;  4ZG6 A;  3BDG B;  1AUK A;  1ELZ A;  1HJK A;  3Q3Q A;  3SZZ A;  1ED8 A;  3TX0 A;  3UO0 A;  2ANH A;  4LRE A;  5K4P A;  4UPH A;  1Y7A A;  2W5R A;  3NVL A;  3WBH A;  2W8D A;  1E33 P;  4LRF A;  3NKR A;  4LR7 A;  4LRB A;  3UN2 A;  4LR8 A;  5LRM A;  2IFY A;  4GTZ A;  1P49 A;  3T00 A;  1EI6 A;  4GTW A;  4LR2 A;  1K7H A;  2W5Q A;  2GLQ A;  3UNY A;  1ANI A;  1ALK A;  4CXU A;  1URA A;  3LXQ A;  4KM4 A;  5EGH A;  2W8S A;  5LRN A;  1KH9 A;  1N2K A;  1AJD A;  5DLT A;  5TJ3 A;  4UOO A;  3IGZ B;  2W5T A;  1N2L A;  1EW9 A;  1HQA A;  3IDD A;  2GSU A;  4TN0 A;  4UPI A;  5DLW A;  2W5W A;  4ZGA A;  1URB A;  5LIA A;  4LRD A;  5INH A;  1ALJ A;  1ALH A;  1E1Z P;  4KJG A;  2W5V A;  3UN5 A;  4LRA A;  1ZEB A;  1O99 A;  3MK1 A;  4GTY A;  4N7T A;  1KH4 A;  1KH7 A;  4B56 A;  1SHN A;  2D1G A;  3A52 A;  1Y6V A;  3NKM A;  3ED4 A;  1ZED A;  3NKQ A;  3NKO A;  2XRG A;  4CYR A;  1KHN A;  3SZY A;  1AJC A;  1E3C P;  2GSO A;  1FSU A;  3WAY A;  4NWJ A;  2RH6 A;  2W5X A;  5LQQ A;  4LR9 A;  5IJQ A;  1KHJ A;  3TG0 A;  1ELX A;  4KAV A;  1EW8 A;  1ELY A;  3M7V A;  2QZU A;  3OT9 A;  2X98 A;  3DPC A;  3MK2 A;  1AJA A;  1HDH A;  3TWZ A;  4MY4 A;  3IGY B;  3WAW A;  5AJ9 A;  5GOV A;  3T02 A;  4KAY A;  5DLV A;  5C66 A;  5EGE A;  4GTX A; 
#chains in the Genus database with same CATH homology
 2GSN A;  3UN3 A;  4LRC A;  5L0B A;  1O98 A;  2G9Y A;  3WAV A;  4UOR A;  4YR1 A;  4CXK A;  4UOP A;  2IUC A;  4CYS A;  3MK0 A;  5GRR A;  1KHL A;  1ZEF A;  4FDJ A;  1KHK A;  1EJJ A;  2GA3 A;  3NKP A;  3T01 A;  5IJS A;  5L0K A;  1AJB A;  3M8Y A;  4ZG7 A;  4CXS A;  3NKN A;  1KH5 A;  4MHX A;  1ALI A;  3B5Q A;  1E2S P;  3BDF A;  1SHQ A;  3KD8 A;  1B8J A;  3BDG A;  5KXA A;  2W5S A;  4QAX A;  3CMR A;  1ANJ A;  4UPL A;  3E2D A;  4KJD A;  4FDI A;  3M8W A;  3WAX A;  3BDH A;  2XR9 A;  1ED9 A;  2IUC B;  4LQY A;  1EW2 A;  2ZKT A;  4ZG9 A;  5HRT A;  3DYC A;  3M8Z A;  2VQR A;  4UPK A;  1EQJ A;  4MIV A;  4NWX A;  5L0E A;  4ZG6 A;  3BDG B;  1AUK A;  1ELZ A;  1HJK A;  3Q3Q A;  3SZZ A;  1ED8 A;  3TX0 A;  3UO0 A;  2ANH A;  4LRE A;  5K4P A;  4UPH A;  1Y7A A;  2W5R A;  3NVL A;  3WBH A;  2W8D A;  1E33 P;  4LRF A;  3NKR A;  4LR7 A;  4LRB A;  3UN2 A;  4LR8 A;  5LRM A;  2IFY A;  4GTZ A;  1P49 A;  3T00 A;  1EI6 A;  4GTW A;  4LR2 A;  1K7H A;  2W5Q A;  2GLQ A;  3UNY A;  1ANI A;  1ALK A;  4CXU A;  1URA A;  3LXQ A;  4KM4 A;  5EGH A;  2W8S A;  5LRN A;  1KH9 A;  1N2K A;  1AJD A;  5DLT A;  5TJ3 A;  4UOO A;  3IGZ B;  2W5T A;  1N2L A;  1EW9 A;  1HQA A;  3IDD A;  2GSU A;  4TN0 A;  4UPI A;  5DLW A;  2W5W A;  4ZGA A;  1URB A;  5LIA A;  4LRD A;  5INH A;  1ALJ A;  1ALH A;  1E1Z P;  4KJG A;  2W5V A;  3UN5 A;  4LRA A;  1ZEB A;  1O99 A;  3MK1 A;  4GTY A;  4N7T A;  1KH4 A;  1KH7 A;  4B56 A;  1SHN A;  2D1G A;  3A52 A;  1Y6V A;  3NKM A;  3ED4 A;  1ZED A;  3NKQ A;  3NKO A;  2XRG A;  4CYR A;  1KHN A;  3SZY A;  1AJC A;  1E3C P;  2GSO A;  1FSU A;  3WAY A;  4NWJ A;  2RH6 A;  2W5X A;  5LQQ A;  4LR9 A;  5IJQ A;  1KHJ A;  3TG0 A;  1ELX A;  4KAV A;  1EW8 A;  1ELY A;  3M7V A;  2QZU A;  3OT9 A;  2X98 A;  3DPC A;  3MK2 A;  1AJA A;  1HDH A;  3TWZ A;  4MY4 A;  3IGY B;  3WAW A;  5AJ9 A;  5GOV A;  3T02 A;  4KAY A;  5DLV A;  5C66 A;  5EGE A;  4GTX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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