1KHJA

E. coli alkaline phosphatase mutant (d153hd330n) mimic of the transition states with aluminium fluoride
Total Genus 156
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
156
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 156
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khjA00
4UPLA 4GTWA 2W5RA 2GLQA 2ZKTA 3WAWA 1SHNA 1K7HA 2GSNA 3T02A 1ED9A 1E1ZP 2QZUA 5C66A 3UNYA 2ANHA 2GSOA 2RH6A 3MK1A 3MK0A 4ZG7A 1KH9A 3NKNA 1ALHA 3B5QA 1EW9A 4GTXA 4CXKA 5LRMA 4GTYA 3UO0A 3NKRA 3WBHA 1ALJA 2IUCA 5L0KA 4CXSA 1E2SP 4FDJA 3A52A 4MY4A 1HQAA 3E2DA 3SZZA 3WAYA 1ANJA 2W5VA 4LRCA 4MIVA 4B56A 1E3CP 5KXAA 5K4PA 4TN0A 3IDDA 4CXUA 3M8YA 1KHLA 4LRBA 3TX0A 2GA3A 1URAA 2GSUA 4ZG9A 4LR8A 1EI6A 1AJBA 1P49A 1ELXA 3DYCA 1AJDA 5EGHA 2W5WA 3WAXA 3T00A 4LR9A 5L0EA 2X98A 1ANIA 1KH4A 3KD8A 4MHXA 5DLVA 1EJJA 1ED8A 1AJCA 1URBA 3UN3A 5EGEA 1HJKA 3IGYB 3CMRA 4LR7A 3BDGB 1KH7A 4UPKA 5DLWA 4N7TA 3NKPA 5IJQA 4LRDA 1N2KA 1ZEFA 5TJ3A 1AUKA 1HDHA 1ALIA 1Y7AA 1EW2A 1KHKA 2W5SA 3TWZA 2W5QA 4GTZA 5HRTA 5GRRA 1KHNA 1AJAA 3BDFA 5GOVA 1ALKA 1ELYA 1EQJA 4NWJA 4UORA 1SHQA 3Q3QA 3LXQA 4YR1A 5IJSA 3M7VA 3BDGA 2W5TA 3UN5A 1N2LA 3NVLA 2XRGA 3WAVA 4ZGAA 2W5XA 5LRNA 2W8DA 4LRFA 4NWXA 1B8JA 4KAYA 4FDIA 4UPHA 3ED4A 2VQRA 1KH5A 3M8WA 4KAVA 4CYRA 3NKMA 1Y6VA 4UOOA 4KJGA 4KM4A 3BDHA 1O98A 2IUCB 2XR9A 3TG0A 4KJDA 4CYSA 2IFYA 1FSUA 5AJ9A 3OT9A 3NKOA 4LR2A 4LRAA 1ELZA 4UOPA 1KHJA 4QAXA 2D1GA 5LQQA 1EW8A 3MK2A 3T01A 1E33P 4LQYA 3IGZB 5DLTA 3DPCA 5INHA 3UN2A 2G9YA 3NKQA 3M8ZA 5LIAA 4ZG6A 4LREA 1O99A 4UPIA 1ZEDA 1ZEBA 5L0BA 2W8SA 3SZYA
chains in the Genus database with same CATH superfamily
4UPLA 4GTWA 2W5RA 2GLQA 2ZKTA 3WAWA 1SHNA 1K7HA 2GSNA 3T02A 1ED9A 1E1ZP 2QZUA 5C66A 3UNYA 2ANHA 2GSOA 2RH6A 3MK1A 3MK0A 4ZG7A 1KH9A 3NKNA 1ALHA 3B5QA 1EW9A 4GTXA 4CXKA 5LRMA 4GTYA 3UO0A 3NKRA 3WBHA 1ALJA 2IUCA 5L0KA 4CXSA 1E2SP 4FDJA 3A52A 4MY4A 1HQAA 3E2DA 3SZZA 3WAYA 1ANJA 2W5VA 4LRCA 4MIVA 4B56A 1E3CP 5KXAA 5K4PA 4TN0A 3IDDA 4CXUA 3M8YA 1KHLA 4LRBA 3TX0A 2GA3A 1URAA 2GSUA 4ZG9A 4LR8A 1EI6A 1AJBA 1P49A 1ELXA 3DYCA 1AJDA 5EGHA 2W5WA 3WAXA 3T00A 4LR9A 5L0EA 2X98A 1ANIA 1KH4A 3KD8A 4MHXA 5DLVA 1EJJA 1ED8A 1AJCA 1URBA 3UN3A 5EGEA 1HJKA 3IGYB 3CMRA 4LR7A 3BDGB 1KH7A 4UPKA 5DLWA 4N7TA 3NKPA 5IJQA 4LRDA 1N2KA 1ZEFA 5TJ3A 1AUKA 1HDHA 1ALIA 1Y7AA 1EW2A 1KHKA 2W5SA 3TWZA 2W5QA 4GTZA 5HRTA 5GRRA 1KHNA 1AJAA 3BDFA 5GOVA 1ALKA 1ELYA 1EQJA 4NWJA 4UORA 1SHQA 3Q3QA 3LXQA 4YR1A 5IJSA 3M7VA 3BDGA 2W5TA 3UN5A 1N2LA 3NVLA 2XRGA 3WAVA 4ZGAA 2W5XA 5LRNA 2W8DA 4LRFA 4NWXA 1B8JA 4KAYA 4FDIA 4UPHA 3ED4A 2VQRA 1KH5A 3M8WA 4KAVA 4CYRA 3NKMA 1Y6VA 4UOOA 4KJGA 4KM4A 3BDHA 1O98A 2IUCB 2XR9A 3TG0A 4KJDA 4CYSA 2IFYA 1FSUA 5AJ9A 3OT9A 3NKOA 4LR2A 4LRAA 1ELZA 4UOPA 1KHJA 4QAXA 2D1GA 5LQQA 1EW8A 3MK2A 3T01A 1E33P 4LQYA 3IGZB 5DLTA 3DPCA 5INHA 3UN2A 2G9YA 3NKQA 3M8ZA 5LIAA 4ZG6A 4LREA 1O99A 4UPIA 1ZEDA 1ZEBA 5L0BA 2W8SA 3SZYA
chains in the Genus database with same CATH topology
4UPLA 4GTWA 2W5RA 2GLQA 2ZKTA 3WAWA 1SHNA 1K7HA 2GSNA 3T02A 1ED9A 1E1ZP 2QZUA 5C66A 3UNYA 2ANHA 2GSOA 2RH6A 3MK1A 3MK0A 4ZG7A 1KH9A 3NKNA 1ALHA 3B5QA 1EW9A 4GTXA 4CXKA 5LRMA 4GTYA 3UO0A 3NKRA 3WBHA 1ALJA 2IUCA 5L0KA 4CXSA 1E2SP 4FDJA 3A52A 4MY4A 1HQAA 3E2DA 3SZZA 3WAYA 1ANJA 2W5VA 4LRCA 4MIVA 4B56A 1E3CP 5KXAA 5K4PA 4TN0A 3IDDA 4CXUA 3M8YA 1KHLA 4LRBA 3TX0A 2GA3A 1URAA 2GSUA 4ZG9A 4LR8A 1EI6A 1AJBA 1P49A 1ELXA 3DYCA 1AJDA 5EGHA 2W5WA 3WAXA 3T00A 4LR9A 5L0EA 2X98A 1ANIA 1KH4A 3KD8A 4MHXA 5DLVA 1EJJA 1ED8A 1AJCA 1URBA 3UN3A 5EGEA 1HJKA 3IGYB 3CMRA 4LR7A 3BDGB 1KH7A 4UPKA 5DLWA 4N7TA 3NKPA 5IJQA 4LRDA 1N2KA 1ZEFA 5TJ3A 1AUKA 1HDHA 1ALIA 1Y7AA 1EW2A 1KHKA 2W5SA 3TWZA 2W5QA 4GTZA 5HRTA 5GRRA 1KHNA 1AJAA 3BDFA 5GOVA 1ALKA 1ELYA 1EQJA 4NWJA 4UORA 1SHQA 3Q3QA 3LXQA 4YR1A 5IJSA 3M7VA 3BDGA 2W5TA 3UN5A 1N2LA 3NVLA 2XRGA 3WAVA 4ZGAA 2W5XA 5LRNA 2W8DA 4LRFA 4NWXA 1B8JA 4KAYA 4FDIA 4UPHA 3ED4A 2VQRA 1KH5A 3M8WA 4KAVA 4CYRA 3NKMA 1Y6VA 4UOOA 4KJGA 4KM4A 3BDHA 1O98A 2IUCB 2XR9A 3TG0A 4KJDA 4CYSA 2IFYA 1FSUA 5AJ9A 3OT9A 3NKOA 4LR2A 4LRAA 1ELZA 4UOPA 1KHJA 4QAXA 2D1GA 5LQQA 1EW8A 3MK2A 3T01A 1E33P 4LQYA 3IGZB 5DLTA 3DPCA 5INHA 3UN2A 2G9YA 3NKQA 3M8ZA 5LIAA 4ZG6A 4LREA 1O99A 4UPIA 1ZEDA 1ZEBA 5L0BA 2W8SA 3SZYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPL A;  4GTW A;  2W5R A;  2GLQ A;  2ZKT A;  3WAW A;  1SHN A;  1K7H A;  2GSN A;  3T02 A;  1ED9 A;  1E1Z P;  2QZU A;  5C66 A;  3UNY A;  2ANH A;  2GSO A;  2RH6 A;  3MK1 A;  3MK0 A;  4ZG7 A;  1KH9 A;  3NKN A;  1ALH A;  3B5Q A;  1EW9 A;  4GTX A;  4CXK A;  5LRM A;  4GTY A;  3UO0 A;  3NKR A;  3WBH A;  1ALJ A;  2IUC A;  5L0K A;  4CXS A;  1E2S P;  4FDJ A;  3A52 A;  4MY4 A;  1HQA A;  3E2D A;  3SZZ A;  3WAY A;  1ANJ A;  2W5V A;  4LRC A;  4MIV A;  4B56 A;  1E3C P;  5KXA A;  5K4P A;  4TN0 A;  3IDD A;  4CXU A;  3M8Y A;  1KHL A;  4LRB A;  3TX0 A;  2GA3 A;  1URA A;  2GSU A;  4ZG9 A;  4LR8 A;  1EI6 A;  1AJB A;  1P49 A;  1ELX A;  3DYC A;  1AJD A;  5EGH A;  2W5W A;  3WAX A;  3T00 A;  4LR9 A;  5L0E A;  2X98 A;  1ANI A;  1KH4 A;  3KD8 A;  4MHX A;  5DLV A;  1EJJ A;  1ED8 A;  1AJC A;  1URB A;  3UN3 A;  5EGE A;  1HJK A;  3IGY B;  3CMR A;  4LR7 A;  3BDG B;  1KH7 A;  4UPK A;  5DLW A;  4N7T A;  3NKP A;  5IJQ A;  4LRD A;  1N2K A;  1ZEF A;  5TJ3 A;  1AUK A;  1HDH A;  1ALI A;  1Y7A A;  1EW2 A;  1KHK A;  2W5S A;  3TWZ A;  2W5Q A;  4GTZ A;  5HRT A;  5GRR A;  1KHN A;  1AJA A;  3BDF A;  5GOV A;  1ALK A;  1ELY A;  1EQJ A;  4NWJ A;  4UOR A;  1SHQ A;  3Q3Q A;  3LXQ A;  4YR1 A;  5IJS A;  3M7V A;  3BDG A;  2W5T A;  3UN5 A;  1N2L A;  3NVL A;  2XRG A;  3WAV A;  4ZGA A;  2W5X A;  5LRN A;  2W8D A;  4LRF A;  4NWX A;  1B8J A;  4KAY A;  4FDI A;  4UPH A;  3ED4 A;  2VQR A;  1KH5 A;  3M8W A;  4KAV A;  4CYR A;  3NKM A;  1Y6V A;  4UOO A;  4KJG A;  4KM4 A;  3BDH A;  1O98 A;  2IUC B;  2XR9 A;  3TG0 A;  4KJD A;  4CYS A;  2IFY A;  1FSU A;  5AJ9 A;  3OT9 A;  3NKO A;  4LR2 A;  4LRA A;  1ELZ A;  4UOP A;  1KHJ A;  4QAX A;  2D1G A;  5LQQ A;  1EW8 A;  3MK2 A;  3T01 A;  1E33 P;  4LQY A;  3IGZ B;  5DLT A;  3DPC A;  5INH A;  3UN2 A;  2G9Y A;  3NKQ A;  3M8Z A;  5LIA A;  4ZG6 A;  4LRE A;  1O99 A;  4UPI A;  1ZED A;  1ZEB A;  5L0B A;  2W8S A;  3SZY A; 
#chains in the Genus database with same CATH topology
 4UPL A;  4GTW A;  2W5R A;  2GLQ A;  2ZKT A;  3WAW A;  1SHN A;  1K7H A;  2GSN A;  3T02 A;  1ED9 A;  1E1Z P;  2QZU A;  5C66 A;  3UNY A;  2ANH A;  2GSO A;  2RH6 A;  3MK1 A;  3MK0 A;  4ZG7 A;  1KH9 A;  3NKN A;  1ALH A;  3B5Q A;  1EW9 A;  4GTX A;  4CXK A;  5LRM A;  4GTY A;  3UO0 A;  3NKR A;  3WBH A;  1ALJ A;  2IUC A;  5L0K A;  4CXS A;  1E2S P;  4FDJ A;  3A52 A;  4MY4 A;  1HQA A;  3E2D A;  3SZZ A;  3WAY A;  1ANJ A;  2W5V A;  4LRC A;  4MIV A;  4B56 A;  1E3C P;  5KXA A;  5K4P A;  4TN0 A;  3IDD A;  4CXU A;  3M8Y A;  1KHL A;  4LRB A;  3TX0 A;  2GA3 A;  1URA A;  2GSU A;  4ZG9 A;  4LR8 A;  1EI6 A;  1AJB A;  1P49 A;  1ELX A;  3DYC A;  1AJD A;  5EGH A;  2W5W A;  3WAX A;  3T00 A;  4LR9 A;  5L0E A;  2X98 A;  1ANI A;  1KH4 A;  3KD8 A;  4MHX A;  5DLV A;  1EJJ A;  1ED8 A;  1AJC A;  1URB A;  3UN3 A;  5EGE A;  1HJK A;  3IGY B;  3CMR A;  4LR7 A;  3BDG B;  1KH7 A;  4UPK A;  5DLW A;  4N7T A;  3NKP A;  5IJQ A;  4LRD A;  1N2K A;  1ZEF A;  5TJ3 A;  1AUK A;  1HDH A;  1ALI A;  1Y7A A;  1EW2 A;  1KHK A;  2W5S A;  3TWZ A;  2W5Q A;  4GTZ A;  5HRT A;  5GRR A;  1KHN A;  1AJA A;  3BDF A;  5GOV A;  1ALK A;  1ELY A;  1EQJ A;  4NWJ A;  4UOR A;  1SHQ A;  3Q3Q A;  3LXQ A;  4YR1 A;  5IJS A;  3M7V A;  3BDG A;  2W5T A;  3UN5 A;  1N2L A;  3NVL A;  2XRG A;  3WAV A;  4ZGA A;  2W5X A;  5LRN A;  2W8D A;  4LRF A;  4NWX A;  1B8J A;  4KAY A;  4FDI A;  4UPH A;  3ED4 A;  2VQR A;  1KH5 A;  3M8W A;  4KAV A;  4CYR A;  3NKM A;  1Y6V A;  4UOO A;  4KJG A;  4KM4 A;  3BDH A;  1O98 A;  2IUC B;  2XR9 A;  3TG0 A;  4KJD A;  4CYS A;  2IFY A;  1FSU A;  5AJ9 A;  3OT9 A;  3NKO A;  4LR2 A;  4LRA A;  1ELZ A;  4UOP A;  1KHJ A;  4QAX A;  2D1G A;  5LQQ A;  1EW8 A;  3MK2 A;  3T01 A;  1E33 P;  4LQY A;  3IGZ B;  5DLT A;  3DPC A;  5INH A;  3UN2 A;  2G9Y A;  3NKQ A;  3M8Z A;  5LIA A;  4ZG6 A;  4LRE A;  1O99 A;  4UPI A;  1ZED A;  1ZEB A;  5L0B A;  2W8S A;  3SZY A; 
#chains in the Genus database with same CATH homology
 4UPL A;  4GTW A;  2W5R A;  2GLQ A;  2ZKT A;  3WAW A;  1SHN A;  1K7H A;  2GSN A;  3T02 A;  1ED9 A;  1E1Z P;  2QZU A;  5C66 A;  3UNY A;  2ANH A;  2GSO A;  2RH6 A;  3MK1 A;  3MK0 A;  4ZG7 A;  1KH9 A;  3NKN A;  1ALH A;  3B5Q A;  1EW9 A;  4GTX A;  4CXK A;  5LRM A;  4GTY A;  3UO0 A;  3NKR A;  3WBH A;  1ALJ A;  2IUC A;  5L0K A;  4CXS A;  1E2S P;  4FDJ A;  3A52 A;  4MY4 A;  1HQA A;  3E2D A;  3SZZ A;  3WAY A;  1ANJ A;  2W5V A;  4LRC A;  4MIV A;  4B56 A;  1E3C P;  5KXA A;  5K4P A;  4TN0 A;  3IDD A;  4CXU A;  3M8Y A;  1KHL A;  4LRB A;  3TX0 A;  2GA3 A;  1URA A;  2GSU A;  4ZG9 A;  4LR8 A;  1EI6 A;  1AJB A;  1P49 A;  1ELX A;  3DYC A;  1AJD A;  5EGH A;  2W5W A;  3WAX A;  3T00 A;  4LR9 A;  5L0E A;  2X98 A;  1ANI A;  1KH4 A;  3KD8 A;  4MHX A;  5DLV A;  1EJJ A;  1ED8 A;  1AJC A;  1URB A;  3UN3 A;  5EGE A;  1HJK A;  3IGY B;  3CMR A;  4LR7 A;  3BDG B;  1KH7 A;  4UPK A;  5DLW A;  4N7T A;  3NKP A;  5IJQ A;  4LRD A;  1N2K A;  1ZEF A;  5TJ3 A;  1AUK A;  1HDH A;  1ALI A;  1Y7A A;  1EW2 A;  1KHK A;  2W5S A;  3TWZ A;  2W5Q A;  4GTZ A;  5HRT A;  5GRR A;  1KHN A;  1AJA A;  3BDF A;  5GOV A;  1ALK A;  1ELY A;  1EQJ A;  4NWJ A;  4UOR A;  1SHQ A;  3Q3Q A;  3LXQ A;  4YR1 A;  5IJS A;  3M7V A;  3BDG A;  2W5T A;  3UN5 A;  1N2L A;  3NVL A;  2XRG A;  3WAV A;  4ZGA A;  2W5X A;  5LRN A;  2W8D A;  4LRF A;  4NWX A;  1B8J A;  4KAY A;  4FDI A;  4UPH A;  3ED4 A;  2VQR A;  1KH5 A;  3M8W A;  4KAV A;  4CYR A;  3NKM A;  1Y6V A;  4UOO A;  4KJG A;  4KM4 A;  3BDH A;  1O98 A;  2IUC B;  2XR9 A;  3TG0 A;  4KJD A;  4CYS A;  2IFY A;  1FSU A;  5AJ9 A;  3OT9 A;  3NKO A;  4LR2 A;  4LRA A;  1ELZ A;  4UOP A;  1KHJ A;  4QAX A;  2D1G A;  5LQQ A;  1EW8 A;  3MK2 A;  3T01 A;  1E33 P;  4LQY A;  3IGZ B;  5DLT A;  3DPC A;  5INH A;  3UN2 A;  2G9Y A;  3NKQ A;  3M8Z A;  5LIA A;  4ZG6 A;  4LRE A;  1O99 A;  4UPI A;  1ZED A;  1ZEB A;  5L0B A;  2W8S A;  3SZY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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