1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
source organism Escherichia coli
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
3BDGA 4LRBA 3BDGB 3B5QA 4MY4A 1ELXA 5K4PA 4CXSA 4CYSA 1KH7A 3WAXA 3M8ZA 3IGYB 3IDDA 1KH5A 4QAXA 2W5WA 3BDHA 1ELZA 5LRMA 4ZG6A 4LR8A 5EGEA 5LRNA 1B8JA 2G9YA 1KH4A 5KXAA 1ALKA 4CXKA 4ZGAA 5IJQA 2GSOA 1KHKA 1E33P 4LRDA 1ALJA 1URAA 4CXUA 4FDJA 3A52A 3ED4A 5INHA 2W5SA 5L0KA 3M8YA 4LQYA 2XR9A 2W5VA 3Q3QA 4FDIA 1EI6A 4GTYA 1KH9A 2GSUA 3UN5A 3T01A 1HDHA 1Y6VA 1ED8A 3LXQA 4ZG7A 1ANJA 2W5QA 5TJ3A 3WAVA 5C66A 4TN0A 2X98A 1ANIA 1N2LA 1Y7AA 5L0EA 3KD8A 4GTWA 3SZZA 3CMRA 4LRCA 1O98A 1AUKA 3DPCA 2GA3A 4ZG9A 2W5RA 4KJGA 2W5XA 4UOPA 5DLWA 5DLVA 1SHQA 4LRAA 2W5TA 1EW9A 3NVLA 1FSUA 5GRRA 3OT9A 3UO0A 5HRTA 3NKQA 2RH6A 1ED9A 2VQRA 3NKRA 3M7VA 3TWZA 1AJDA 3NKPA 4KM4A 3DYCA 4LR9A 4N7TA 2W8SA 3NKOA 4NWJA 1KHNA 3NKNA 4NWXA 4LRFA 1ALHA 1EW2A 1ELYA 3UN3A 4UPLA 4GTZA 2XRGA 5LIAA 1HJKA 1KHLA 2GLQA 1E2SP 1SHNA 2ANHA 4LR7A 1EW8A 3MK0A 3E2DA 1ZEFA 1KHJA 4UORA 5L0BA 1HQAA 3M8WA 1AJCA 1N2KA 2IFYA 3MK2A 4UOOA 1P49A 4MHXA 1EQJA 2QZUA 3MK1A 3SZYA 3T02A 5DLTA 1AJAA 3WAYA 3UN2A 3TG0A 2W8DA 1ZEDA 2D1GA 1E3CP 1AJBA 4YR1A 4KAYA 3WBHA 2ZKTA 3NKMA 3WAWA 4B56A 4KAVA 2IUCA 4LR2A 2IUCB 1EJJA 3TX0A 1URBA 5GOVA 1ZEBA 5AJ9A 4UPKA 5EGHA 3BDFA 1K7HA 1O99A 3IGZB 4CYRA 4UPHA 2GSNA 4KJDA 3UNYA 4GTXA 1E1ZP 4MIVA 4UPIA 5IJSA 4LREA 1ALIA 5LQQA 3T00A
chains in the Genus database with same CATH superfamily
3BDGA 4LRBA 3BDGB 3B5QA 4MY4A 1ELXA 5K4PA 4CXSA 4CYSA 1KH7A 3WAXA 3M8ZA 3IGYB 3IDDA 1KH5A 4QAXA 2W5WA 3BDHA 1ELZA 5LRMA 4ZG6A 4LR8A 5EGEA 5LRNA 1B8JA 2G9YA 1KH4A 5KXAA 1ALKA 4CXKA 4ZGAA 5IJQA 2GSOA 1KHKA 1E33P 4LRDA 1ALJA 1URAA 4CXUA 4FDJA 3A52A 3ED4A 5INHA 2W5SA 5L0KA 3M8YA 4LQYA 2XR9A 2W5VA 3Q3QA 4FDIA 1EI6A 4GTYA 1KH9A 2GSUA 3UN5A 3T01A 1HDHA 1Y6VA 1ED8A 3LXQA 4ZG7A 1ANJA 2W5QA 5TJ3A 3WAVA 5C66A 4TN0A 2X98A 1ANIA 1N2LA 1Y7AA 5L0EA 3KD8A 4GTWA 3SZZA 3CMRA 4LRCA 1O98A 1AUKA 3DPCA 2GA3A 4ZG9A 2W5RA 4KJGA 2W5XA 4UOPA 5DLWA 5DLVA 1SHQA 4LRAA 2W5TA 1EW9A 3NVLA 1FSUA 5GRRA 3OT9A 3UO0A 5HRTA 3NKQA 2RH6A 1ED9A 2VQRA 3NKRA 3M7VA 3TWZA 1AJDA 3NKPA 4KM4A 3DYCA 4LR9A 4N7TA 2W8SA 3NKOA 4NWJA 1KHNA 3NKNA 4NWXA 4LRFA 1ALHA 1EW2A 1ELYA 3UN3A 4UPLA 4GTZA 2XRGA 5LIAA 1HJKA 1KHLA 2GLQA 1E2SP 1SHNA 2ANHA 4LR7A 1EW8A 3MK0A 3E2DA 1ZEFA 1KHJA 4UORA 5L0BA 1HQAA 3M8WA 1AJCA 1N2KA 2IFYA 3MK2A 4UOOA 1P49A 4MHXA 1EQJA 2QZUA 3MK1A 3SZYA 3T02A 5DLTA 1AJAA 3WAYA 3UN2A 3TG0A 2W8DA 1ZEDA 2D1GA 1E3CP 1AJBA 4YR1A 4KAYA 3WBHA 2ZKTA 3NKMA 3WAWA 4B56A 4KAVA 2IUCA 4LR2A 2IUCB 1EJJA 3TX0A 1URBA 5GOVA 1ZEBA 5AJ9A 4UPKA 5EGHA 3BDFA 1K7HA 1O99A 3IGZB 4CYRA 4UPHA 2GSNA 4KJDA 3UNYA 4GTXA 1E1ZP 4MIVA 4UPIA 5IJSA 4LREA 1ALIA 5LQQA 3T00A
chains in the Genus database with same CATH topology
3BDGA 4LRBA 3BDGB 3B5QA 4MY4A 1ELXA 5K4PA 4CXSA 4CYSA 1KH7A 3WAXA 3M8ZA 3IGYB 3IDDA 1KH5A 4QAXA 2W5WA 3BDHA 1ELZA 5LRMA 4ZG6A 4LR8A 5EGEA 5LRNA 1B8JA 2G9YA 1KH4A 5KXAA 1ALKA 4CXKA 4ZGAA 5IJQA 2GSOA 1KHKA 1E33P 4LRDA 1ALJA 1URAA 4CXUA 4FDJA 3A52A 3ED4A 5INHA 2W5SA 5L0KA 3M8YA 4LQYA 2XR9A 2W5VA 3Q3QA 4FDIA 1EI6A 4GTYA 1KH9A 2GSUA 3UN5A 3T01A 1HDHA 1Y6VA 1ED8A 3LXQA 4ZG7A 1ANJA 2W5QA 5TJ3A 3WAVA 5C66A 4TN0A 2X98A 1ANIA 1N2LA 1Y7AA 5L0EA 3KD8A 4GTWA 3SZZA 3CMRA 4LRCA 1O98A 1AUKA 3DPCA 2GA3A 4ZG9A 2W5RA 4KJGA 2W5XA 4UOPA 5DLWA 5DLVA 1SHQA 4LRAA 2W5TA 1EW9A 3NVLA 1FSUA 5GRRA 3OT9A 3UO0A 5HRTA 3NKQA 2RH6A 1ED9A 2VQRA 3NKRA 3M7VA 3TWZA 1AJDA 3NKPA 4KM4A 3DYCA 4LR9A 4N7TA 2W8SA 3NKOA 4NWJA 1KHNA 3NKNA 4NWXA 4LRFA 1ALHA 1EW2A 1ELYA 3UN3A 4UPLA 4GTZA 2XRGA 5LIAA 1HJKA 1KHLA 2GLQA 1E2SP 1SHNA 2ANHA 4LR7A 1EW8A 3MK0A 3E2DA 1ZEFA 1KHJA 4UORA 5L0BA 1HQAA 3M8WA 1AJCA 1N2KA 2IFYA 3MK2A 4UOOA 1P49A 4MHXA 1EQJA 2QZUA 3MK1A 3SZYA 3T02A 5DLTA 1AJAA 3WAYA 3UN2A 3TG0A 2W8DA 1ZEDA 2D1GA 1E3CP 1AJBA 4YR1A 4KAYA 3WBHA 2ZKTA 3NKMA 3WAWA 4B56A 4KAVA 2IUCA 4LR2A 2IUCB 1EJJA 3TX0A 1URBA 5GOVA 1ZEBA 5AJ9A 4UPKA 5EGHA 3BDFA 1K7HA 1O99A 3IGZB 4CYRA 4UPHA 2GSNA 4KJDA 3UNYA 4GTXA 1E1ZP 4MIVA 4UPIA 5IJSA 4LREA 1ALIA 5LQQA 3T00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDG A;  4LRB A;  3BDG B;  3B5Q A;  4MY4 A;  1ELX A;  5K4P A;  4CXS A;  4CYS A;  1KH7 A;  3WAX A;  3M8Z A;  3IGY B;  3IDD A;  1KH5 A;  4QAX A;  2W5W A;  3BDH A;  1ELZ A;  5LRM A;  4ZG6 A;  4LR8 A;  5EGE A;  5LRN A;  1B8J A;  2G9Y A;  1KH4 A;  5KXA A;  1ALK A;  4CXK A;  4ZGA A;  5IJQ A;  2GSO A;  1KHK A;  1E33 P;  4LRD A;  1ALJ A;  1URA A;  4CXU A;  4FDJ A;  3A52 A;  3ED4 A;  5INH A;  2W5S A;  5L0K A;  3M8Y A;  4LQY A;  2XR9 A;  2W5V A;  3Q3Q A;  4FDI A;  1EI6 A;  4GTY A;  1KH9 A;  2GSU A;  3UN5 A;  3T01 A;  1HDH A;  1Y6V A;  1ED8 A;  3LXQ A;  4ZG7 A;  1ANJ A;  2W5Q A;  5TJ3 A;  3WAV A;  5C66 A;  4TN0 A;  2X98 A;  1ANI A;  1N2L A;  1Y7A A;  5L0E A;  3KD8 A;  4GTW A;  3SZZ A;  3CMR A;  4LRC A;  1O98 A;  1AUK A;  3DPC A;  2GA3 A;  4ZG9 A;  2W5R A;  4KJG A;  2W5X A;  4UOP A;  5DLW A;  5DLV A;  1SHQ A;  4LRA A;  2W5T A;  1EW9 A;  3NVL A;  1FSU A;  5GRR A;  3OT9 A;  3UO0 A;  5HRT A;  3NKQ A;  2RH6 A;  1ED9 A;  2VQR A;  3NKR A;  3M7V A;  3TWZ A;  1AJD A;  3NKP A;  4KM4 A;  3DYC A;  4LR9 A;  4N7T A;  2W8S A;  3NKO A;  4NWJ A;  1KHN A;  3NKN A;  4NWX A;  4LRF A;  1ALH A;  1EW2 A;  1ELY A;  3UN3 A;  4UPL A;  4GTZ A;  2XRG A;  5LIA A;  1HJK A;  1KHL A;  2GLQ A;  1E2S P;  1SHN A;  2ANH A;  4LR7 A;  1EW8 A;  3MK0 A;  3E2D A;  1ZEF A;  1KHJ A;  4UOR A;  5L0B A;  1HQA A;  3M8W A;  1AJC A;  1N2K A;  2IFY A;  3MK2 A;  4UOO A;  1P49 A;  4MHX A;  1EQJ A;  2QZU A;  3MK1 A;  3SZY A;  3T02 A;  5DLT A;  1AJA A;  3WAY A;  3UN2 A;  3TG0 A;  2W8D A;  1ZED A;  2D1G A;  1E3C P;  1AJB A;  4YR1 A;  4KAY A;  3WBH A;  2ZKT A;  3NKM A;  3WAW A;  4B56 A;  4KAV A;  2IUC A;  4LR2 A;  2IUC B;  1EJJ A;  3TX0 A;  1URB A;  5GOV A;  1ZEB A;  5AJ9 A;  4UPK A;  5EGH A;  3BDF A;  1K7H A;  1O99 A;  3IGZ B;  4CYR A;  4UPH A;  2GSN A;  4KJD A;  3UNY A;  4GTX A;  1E1Z P;  4MIV A;  4UPI A;  5IJS A;  4LRE A;  1ALI A;  5LQQ A;  3T00 A; 
#chains in the Genus database with same CATH topology
 3BDG A;  4LRB A;  3BDG B;  3B5Q A;  4MY4 A;  1ELX A;  5K4P A;  4CXS A;  4CYS A;  1KH7 A;  3WAX A;  3M8Z A;  3IGY B;  3IDD A;  1KH5 A;  4QAX A;  2W5W A;  3BDH A;  1ELZ A;  5LRM A;  4ZG6 A;  4LR8 A;  5EGE A;  5LRN A;  1B8J A;  2G9Y A;  1KH4 A;  5KXA A;  1ALK A;  4CXK A;  4ZGA A;  5IJQ A;  2GSO A;  1KHK A;  1E33 P;  4LRD A;  1ALJ A;  1URA A;  4CXU A;  4FDJ A;  3A52 A;  3ED4 A;  5INH A;  2W5S A;  5L0K A;  3M8Y A;  4LQY A;  2XR9 A;  2W5V A;  3Q3Q A;  4FDI A;  1EI6 A;  4GTY A;  1KH9 A;  2GSU A;  3UN5 A;  3T01 A;  1HDH A;  1Y6V A;  1ED8 A;  3LXQ A;  4ZG7 A;  1ANJ A;  2W5Q A;  5TJ3 A;  3WAV A;  5C66 A;  4TN0 A;  2X98 A;  1ANI A;  1N2L A;  1Y7A A;  5L0E A;  3KD8 A;  4GTW A;  3SZZ A;  3CMR A;  4LRC A;  1O98 A;  1AUK A;  3DPC A;  2GA3 A;  4ZG9 A;  2W5R A;  4KJG A;  2W5X A;  4UOP A;  5DLW A;  5DLV A;  1SHQ A;  4LRA A;  2W5T A;  1EW9 A;  3NVL A;  1FSU A;  5GRR A;  3OT9 A;  3UO0 A;  5HRT A;  3NKQ A;  2RH6 A;  1ED9 A;  2VQR A;  3NKR A;  3M7V A;  3TWZ A;  1AJD A;  3NKP A;  4KM4 A;  3DYC A;  4LR9 A;  4N7T A;  2W8S A;  3NKO A;  4NWJ A;  1KHN A;  3NKN A;  4NWX A;  4LRF A;  1ALH A;  1EW2 A;  1ELY A;  3UN3 A;  4UPL A;  4GTZ A;  2XRG A;  5LIA A;  1HJK A;  1KHL A;  2GLQ A;  1E2S P;  1SHN A;  2ANH A;  4LR7 A;  1EW8 A;  3MK0 A;  3E2D A;  1ZEF A;  1KHJ A;  4UOR A;  5L0B A;  1HQA A;  3M8W A;  1AJC A;  1N2K A;  2IFY A;  3MK2 A;  4UOO A;  1P49 A;  4MHX A;  1EQJ A;  2QZU A;  3MK1 A;  3SZY A;  3T02 A;  5DLT A;  1AJA A;  3WAY A;  3UN2 A;  3TG0 A;  2W8D A;  1ZED A;  2D1G A;  1E3C P;  1AJB A;  4YR1 A;  4KAY A;  3WBH A;  2ZKT A;  3NKM A;  3WAW A;  4B56 A;  4KAV A;  2IUC A;  4LR2 A;  2IUC B;  1EJJ A;  3TX0 A;  1URB A;  5GOV A;  1ZEB A;  5AJ9 A;  4UPK A;  5EGH A;  3BDF A;  1K7H A;  1O99 A;  3IGZ B;  4CYR A;  4UPH A;  2GSN A;  4KJD A;  3UNY A;  4GTX A;  1E1Z P;  4MIV A;  4UPI A;  5IJS A;  4LRE A;  1ALI A;  5LQQ A;  3T00 A; 
#chains in the Genus database with same CATH homology
 3BDG A;  4LRB A;  3BDG B;  3B5Q A;  4MY4 A;  1ELX A;  5K4P A;  4CXS A;  4CYS A;  1KH7 A;  3WAX A;  3M8Z A;  3IGY B;  3IDD A;  1KH5 A;  4QAX A;  2W5W A;  3BDH A;  1ELZ A;  5LRM A;  4ZG6 A;  4LR8 A;  5EGE A;  5LRN A;  1B8J A;  2G9Y A;  1KH4 A;  5KXA A;  1ALK A;  4CXK A;  4ZGA A;  5IJQ A;  2GSO A;  1KHK A;  1E33 P;  4LRD A;  1ALJ A;  1URA A;  4CXU A;  4FDJ A;  3A52 A;  3ED4 A;  5INH A;  2W5S A;  5L0K A;  3M8Y A;  4LQY A;  2XR9 A;  2W5V A;  3Q3Q A;  4FDI A;  1EI6 A;  4GTY A;  1KH9 A;  2GSU A;  3UN5 A;  3T01 A;  1HDH A;  1Y6V A;  1ED8 A;  3LXQ A;  4ZG7 A;  1ANJ A;  2W5Q A;  5TJ3 A;  3WAV A;  5C66 A;  4TN0 A;  2X98 A;  1ANI A;  1N2L A;  1Y7A A;  5L0E A;  3KD8 A;  4GTW A;  3SZZ A;  3CMR A;  4LRC A;  1O98 A;  1AUK A;  3DPC A;  2GA3 A;  4ZG9 A;  2W5R A;  4KJG A;  2W5X A;  4UOP A;  5DLW A;  5DLV A;  1SHQ A;  4LRA A;  2W5T A;  1EW9 A;  3NVL A;  1FSU A;  5GRR A;  3OT9 A;  3UO0 A;  5HRT A;  3NKQ A;  2RH6 A;  1ED9 A;  2VQR A;  3NKR A;  3M7V A;  3TWZ A;  1AJD A;  3NKP A;  4KM4 A;  3DYC A;  4LR9 A;  4N7T A;  2W8S A;  3NKO A;  4NWJ A;  1KHN A;  3NKN A;  4NWX A;  4LRF A;  1ALH A;  1EW2 A;  1ELY A;  3UN3 A;  4UPL A;  4GTZ A;  2XRG A;  5LIA A;  1HJK A;  1KHL A;  2GLQ A;  1E2S P;  1SHN A;  2ANH A;  4LR7 A;  1EW8 A;  3MK0 A;  3E2D A;  1ZEF A;  1KHJ A;  4UOR A;  5L0B A;  1HQA A;  3M8W A;  1AJC A;  1N2K A;  2IFY A;  3MK2 A;  4UOO A;  1P49 A;  4MHX A;  1EQJ A;  2QZU A;  3MK1 A;  3SZY A;  3T02 A;  5DLT A;  1AJA A;  3WAY A;  3UN2 A;  3TG0 A;  2W8D A;  1ZED A;  2D1G A;  1E3C P;  1AJB A;  4YR1 A;  4KAY A;  3WBH A;  2ZKT A;  3NKM A;  3WAW A;  4B56 A;  4KAV A;  2IUC A;  4LR2 A;  2IUC B;  1EJJ A;  3TX0 A;  1URB A;  5GOV A;  1ZEB A;  5AJ9 A;  4UPK A;  5EGH A;  3BDF A;  1K7H A;  1O99 A;  3IGZ B;  4CYR A;  4UPH A;  2GSN A;  4KJD A;  3UNY A;  4GTX A;  1E1Z P;  4MIV A;  4UPI A;  5IJS A;  4LRE A;  1ALI A;  5LQQ A;  3T00 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...