1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
4KJGA 1KH4A 4ZG6A 1AJCA 3M7VA 1ELZA 1ELYA 3BDGA 1B8JA 3MK0A 4ZG9A 2ZKTA 3MK1A 1EI6A 4CXKA 3DYCA 2QZUA 4LRDA 3T01A 3DPCA 4CXSA 4LR2A 4MY4A 3WAWA 1E1ZP 5L0KA 1SHNA 1EW9A 1HJKA 5C66A 3M8ZA 1AUKA 1AJAA 5GRRA 4UPKA 2W5TA 3UN3A 5IJQA 4MHXA 5L0EA 4ZG7A 4CYSA 3SZZA 3WAXA 5L0BA 1N2KA 5K4PA 2GSNA 2W8DA 1ALHA 1ALKA 3TG0A 2GSUA 2W5QA 1KH5A 3Q3QA 2IFYA 2W5VA 4GTXA 4CXUA 4LREA 4B56A 3WAYA 5KXAA 2W8SA 2W5WA 4LQYA 3T02A 4LRCA 3B5QA 4QAXA 1KHKA 3IGYB 1AJBA 1K7HA 2XR9A 2W5XA 5LQQA 3IGZB 1ZEFA 3BDFA 2G9YA 1P49A 3BDHA 1ALIA 4ZGAA 3M8YA 5HRTA 1SHQA 2W5SA 1E2SP 3UN2A 2IUCB 4MIVA 4UPIA 5GOVA 5LRMA 4LR7A 3OT9A 4LRBA 1ANIA 5DLWA 1ANJA 4CYRA 1KH9A 2IUCA 2X98A 1ZEBA 3NKRA 1AJDA 1E3CP 5TJ3A 2RH6A 2VQRA 5LRNA 1KH7A 4YR1A 5IJSA 4KAYA 3M8WA 5AJ9A 2XRGA 4UPLA 1ED8A 2ANHA 3NKNA 1HDHA 4LRFA 1ELXA 1HQAA 2D1GA 3NKQA 4LRAA 4UORA 1URBA 3SZYA 4GTYA 3BDGB 3WAVA 3IDDA 3T00A 1KHNA 3UN5A 3LXQA 2GA3A 3ED4A 5EGHA 2GSOA 1EW8A 3TWZA 1ZEDA 1O98A 3WBHA 3KD8A 1FSUA 4FDJA 1EJJA 4N7TA 5DLTA 1URAA 3A52A 2W5RA 3UNYA 1ED9A 3NVLA 5EGEA 4NWXA 1Y7AA 3CMRA 1Y6VA 4KAVA 4GTWA 3MK2A 4LR8A 3NKMA 4NWJA 4KJDA 3NKPA 1ALJA 4UOOA 1KHLA 4UPHA 4UOPA 4GTZA 4FDIA 1KHJA 3NKOA 4LR9A 1EQJA 5DLVA 3UO0A 4TN0A 5INHA 1E33P 1N2LA 1EW2A 4KM4A 5LIAA 3E2DA 2GLQA 3TX0A 1O99A
chains in the Genus database with same CATH superfamily
4KJGA 1KH4A 4ZG6A 1AJCA 3M7VA 1ELZA 1ELYA 3BDGA 1B8JA 3MK0A 4ZG9A 2ZKTA 3MK1A 1EI6A 4CXKA 3DYCA 2QZUA 4LRDA 3T01A 3DPCA 4CXSA 4LR2A 4MY4A 3WAWA 1E1ZP 5L0KA 1SHNA 1EW9A 1HJKA 5C66A 3M8ZA 1AUKA 1AJAA 5GRRA 4UPKA 2W5TA 3UN3A 5IJQA 4MHXA 5L0EA 4ZG7A 4CYSA 3SZZA 3WAXA 5L0BA 1N2KA 5K4PA 2GSNA 2W8DA 1ALHA 1ALKA 3TG0A 2GSUA 2W5QA 1KH5A 3Q3QA 2IFYA 2W5VA 4GTXA 4CXUA 4LREA 4B56A 3WAYA 5KXAA 2W8SA 2W5WA 4LQYA 3T02A 4LRCA 3B5QA 4QAXA 1KHKA 3IGYB 1AJBA 1K7HA 2XR9A 2W5XA 5LQQA 3IGZB 1ZEFA 3BDFA 2G9YA 1P49A 3BDHA 1ALIA 4ZGAA 3M8YA 5HRTA 1SHQA 2W5SA 1E2SP 3UN2A 2IUCB 4MIVA 4UPIA 5GOVA 5LRMA 4LR7A 3OT9A 4LRBA 1ANIA 5DLWA 1ANJA 4CYRA 1KH9A 2IUCA 2X98A 1ZEBA 3NKRA 1AJDA 1E3CP 5TJ3A 2RH6A 2VQRA 5LRNA 1KH7A 4YR1A 5IJSA 4KAYA 3M8WA 5AJ9A 2XRGA 4UPLA 1ED8A 2ANHA 3NKNA 1HDHA 4LRFA 1ELXA 1HQAA 2D1GA 3NKQA 4LRAA 4UORA 1URBA 3SZYA 4GTYA 3BDGB 3WAVA 3IDDA 3T00A 1KHNA 3UN5A 3LXQA 2GA3A 3ED4A 5EGHA 2GSOA 1EW8A 3TWZA 1ZEDA 1O98A 3WBHA 3KD8A 1FSUA 4FDJA 1EJJA 4N7TA 5DLTA 1URAA 3A52A 2W5RA 3UNYA 1ED9A 3NVLA 5EGEA 4NWXA 1Y7AA 3CMRA 1Y6VA 4KAVA 4GTWA 3MK2A 4LR8A 3NKMA 4NWJA 4KJDA 3NKPA 1ALJA 4UOOA 1KHLA 4UPHA 4UOPA 4GTZA 4FDIA 1KHJA 3NKOA 4LR9A 1EQJA 5DLVA 3UO0A 4TN0A 5INHA 1E33P 1N2LA 1EW2A 4KM4A 5LIAA 3E2DA 2GLQA 3TX0A 1O99A
chains in the Genus database with same CATH topology
4KJGA 1KH4A 4ZG6A 1AJCA 3M7VA 1ELZA 1ELYA 3BDGA 1B8JA 3MK0A 4ZG9A 2ZKTA 3MK1A 1EI6A 4CXKA 3DYCA 2QZUA 4LRDA 3T01A 3DPCA 4CXSA 4LR2A 4MY4A 3WAWA 1E1ZP 5L0KA 1SHNA 1EW9A 1HJKA 5C66A 3M8ZA 1AUKA 1AJAA 5GRRA 4UPKA 2W5TA 3UN3A 5IJQA 4MHXA 5L0EA 4ZG7A 4CYSA 3SZZA 3WAXA 5L0BA 1N2KA 5K4PA 2GSNA 2W8DA 1ALHA 1ALKA 3TG0A 2GSUA 2W5QA 1KH5A 3Q3QA 2IFYA 2W5VA 4GTXA 4CXUA 4LREA 4B56A 3WAYA 5KXAA 2W8SA 2W5WA 4LQYA 3T02A 4LRCA 3B5QA 4QAXA 1KHKA 3IGYB 1AJBA 1K7HA 2XR9A 2W5XA 5LQQA 3IGZB 1ZEFA 3BDFA 2G9YA 1P49A 3BDHA 1ALIA 4ZGAA 3M8YA 5HRTA 1SHQA 2W5SA 1E2SP 3UN2A 2IUCB 4MIVA 4UPIA 5GOVA 5LRMA 4LR7A 3OT9A 4LRBA 1ANIA 5DLWA 1ANJA 4CYRA 1KH9A 2IUCA 2X98A 1ZEBA 3NKRA 1AJDA 1E3CP 5TJ3A 2RH6A 2VQRA 5LRNA 1KH7A 4YR1A 5IJSA 4KAYA 3M8WA 5AJ9A 2XRGA 4UPLA 1ED8A 2ANHA 3NKNA 1HDHA 4LRFA 1ELXA 1HQAA 2D1GA 3NKQA 4LRAA 4UORA 1URBA 3SZYA 4GTYA 3BDGB 3WAVA 3IDDA 3T00A 1KHNA 3UN5A 3LXQA 2GA3A 3ED4A 5EGHA 2GSOA 1EW8A 3TWZA 1ZEDA 1O98A 3WBHA 3KD8A 1FSUA 4FDJA 1EJJA 4N7TA 5DLTA 1URAA 3A52A 2W5RA 3UNYA 1ED9A 3NVLA 5EGEA 4NWXA 1Y7AA 3CMRA 1Y6VA 4KAVA 4GTWA 3MK2A 4LR8A 3NKMA 4NWJA 4KJDA 3NKPA 1ALJA 4UOOA 1KHLA 4UPHA 4UOPA 4GTZA 4FDIA 1KHJA 3NKOA 4LR9A 1EQJA 5DLVA 3UO0A 4TN0A 5INHA 1E33P 1N2LA 1EW2A 4KM4A 5LIAA 3E2DA 2GLQA 3TX0A 1O99A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KJG A;  1KH4 A;  4ZG6 A;  1AJC A;  3M7V A;  1ELZ A;  1ELY A;  3BDG A;  1B8J A;  3MK0 A;  4ZG9 A;  2ZKT A;  3MK1 A;  1EI6 A;  4CXK A;  3DYC A;  2QZU A;  4LRD A;  3T01 A;  3DPC A;  4CXS A;  4LR2 A;  4MY4 A;  3WAW A;  1E1Z P;  5L0K A;  1SHN A;  1EW9 A;  1HJK A;  5C66 A;  3M8Z A;  1AUK A;  1AJA A;  5GRR A;  4UPK A;  2W5T A;  3UN3 A;  5IJQ A;  4MHX A;  5L0E A;  4ZG7 A;  4CYS A;  3SZZ A;  3WAX A;  5L0B A;  1N2K A;  5K4P A;  2GSN A;  2W8D A;  1ALH A;  1ALK A;  3TG0 A;  2GSU A;  2W5Q A;  1KH5 A;  3Q3Q A;  2IFY A;  2W5V A;  4GTX A;  4CXU A;  4LRE A;  4B56 A;  3WAY A;  5KXA A;  2W8S A;  2W5W A;  4LQY A;  3T02 A;  4LRC A;  3B5Q A;  4QAX A;  1KHK A;  3IGY B;  1AJB A;  1K7H A;  2XR9 A;  2W5X A;  5LQQ A;  3IGZ B;  1ZEF A;  3BDF A;  2G9Y A;  1P49 A;  3BDH A;  1ALI A;  4ZGA A;  3M8Y A;  5HRT A;  1SHQ A;  2W5S A;  1E2S P;  3UN2 A;  2IUC B;  4MIV A;  4UPI A;  5GOV A;  5LRM A;  4LR7 A;  3OT9 A;  4LRB A;  1ANI A;  5DLW A;  1ANJ A;  4CYR A;  1KH9 A;  2IUC A;  2X98 A;  1ZEB A;  3NKR A;  1AJD A;  1E3C P;  5TJ3 A;  2RH6 A;  2VQR A;  5LRN A;  1KH7 A;  4YR1 A;  5IJS A;  4KAY A;  3M8W A;  5AJ9 A;  2XRG A;  4UPL A;  1ED8 A;  2ANH A;  3NKN A;  1HDH A;  4LRF A;  1ELX A;  1HQA A;  2D1G A;  3NKQ A;  4LRA A;  4UOR A;  1URB A;  3SZY A;  4GTY A;  3BDG B;  3WAV A;  3IDD A;  3T00 A;  1KHN A;  3UN5 A;  3LXQ A;  2GA3 A;  3ED4 A;  5EGH A;  2GSO A;  1EW8 A;  3TWZ A;  1ZED A;  1O98 A;  3WBH A;  3KD8 A;  1FSU A;  4FDJ A;  1EJJ A;  4N7T A;  5DLT A;  1URA A;  3A52 A;  2W5R A;  3UNY A;  1ED9 A;  3NVL A;  5EGE A;  4NWX A;  1Y7A A;  3CMR A;  1Y6V A;  4KAV A;  4GTW A;  3MK2 A;  4LR8 A;  3NKM A;  4NWJ A;  4KJD A;  3NKP A;  1ALJ A;  4UOO A;  1KHL A;  4UPH A;  4UOP A;  4GTZ A;  4FDI A;  1KHJ A;  3NKO A;  4LR9 A;  1EQJ A;  5DLV A;  3UO0 A;  4TN0 A;  5INH A;  1E33 P;  1N2L A;  1EW2 A;  4KM4 A;  5LIA A;  3E2D A;  2GLQ A;  3TX0 A;  1O99 A; 
#chains in the Genus database with same CATH topology
 4KJG A;  1KH4 A;  4ZG6 A;  1AJC A;  3M7V A;  1ELZ A;  1ELY A;  3BDG A;  1B8J A;  3MK0 A;  4ZG9 A;  2ZKT A;  3MK1 A;  1EI6 A;  4CXK A;  3DYC A;  2QZU A;  4LRD A;  3T01 A;  3DPC A;  4CXS A;  4LR2 A;  4MY4 A;  3WAW A;  1E1Z P;  5L0K A;  1SHN A;  1EW9 A;  1HJK A;  5C66 A;  3M8Z A;  1AUK A;  1AJA A;  5GRR A;  4UPK A;  2W5T A;  3UN3 A;  5IJQ A;  4MHX A;  5L0E A;  4ZG7 A;  4CYS A;  3SZZ A;  3WAX A;  5L0B A;  1N2K A;  5K4P A;  2GSN A;  2W8D A;  1ALH A;  1ALK A;  3TG0 A;  2GSU A;  2W5Q A;  1KH5 A;  3Q3Q A;  2IFY A;  2W5V A;  4GTX A;  4CXU A;  4LRE A;  4B56 A;  3WAY A;  5KXA A;  2W8S A;  2W5W A;  4LQY A;  3T02 A;  4LRC A;  3B5Q A;  4QAX A;  1KHK A;  3IGY B;  1AJB A;  1K7H A;  2XR9 A;  2W5X A;  5LQQ A;  3IGZ B;  1ZEF A;  3BDF A;  2G9Y A;  1P49 A;  3BDH A;  1ALI A;  4ZGA A;  3M8Y A;  5HRT A;  1SHQ A;  2W5S A;  1E2S P;  3UN2 A;  2IUC B;  4MIV A;  4UPI A;  5GOV A;  5LRM A;  4LR7 A;  3OT9 A;  4LRB A;  1ANI A;  5DLW A;  1ANJ A;  4CYR A;  1KH9 A;  2IUC A;  2X98 A;  1ZEB A;  3NKR A;  1AJD A;  1E3C P;  5TJ3 A;  2RH6 A;  2VQR A;  5LRN A;  1KH7 A;  4YR1 A;  5IJS A;  4KAY A;  3M8W A;  5AJ9 A;  2XRG A;  4UPL A;  1ED8 A;  2ANH A;  3NKN A;  1HDH A;  4LRF A;  1ELX A;  1HQA A;  2D1G A;  3NKQ A;  4LRA A;  4UOR A;  1URB A;  3SZY A;  4GTY A;  3BDG B;  3WAV A;  3IDD A;  3T00 A;  1KHN A;  3UN5 A;  3LXQ A;  2GA3 A;  3ED4 A;  5EGH A;  2GSO A;  1EW8 A;  3TWZ A;  1ZED A;  1O98 A;  3WBH A;  3KD8 A;  1FSU A;  4FDJ A;  1EJJ A;  4N7T A;  5DLT A;  1URA A;  3A52 A;  2W5R A;  3UNY A;  1ED9 A;  3NVL A;  5EGE A;  4NWX A;  1Y7A A;  3CMR A;  1Y6V A;  4KAV A;  4GTW A;  3MK2 A;  4LR8 A;  3NKM A;  4NWJ A;  4KJD A;  3NKP A;  1ALJ A;  4UOO A;  1KHL A;  4UPH A;  4UOP A;  4GTZ A;  4FDI A;  1KHJ A;  3NKO A;  4LR9 A;  1EQJ A;  5DLV A;  3UO0 A;  4TN0 A;  5INH A;  1E33 P;  1N2L A;  1EW2 A;  4KM4 A;  5LIA A;  3E2D A;  2GLQ A;  3TX0 A;  1O99 A; 
#chains in the Genus database with same CATH homology
 4KJG A;  1KH4 A;  4ZG6 A;  1AJC A;  3M7V A;  1ELZ A;  1ELY A;  3BDG A;  1B8J A;  3MK0 A;  4ZG9 A;  2ZKT A;  3MK1 A;  1EI6 A;  4CXK A;  3DYC A;  2QZU A;  4LRD A;  3T01 A;  3DPC A;  4CXS A;  4LR2 A;  4MY4 A;  3WAW A;  1E1Z P;  5L0K A;  1SHN A;  1EW9 A;  1HJK A;  5C66 A;  3M8Z A;  1AUK A;  1AJA A;  5GRR A;  4UPK A;  2W5T A;  3UN3 A;  5IJQ A;  4MHX A;  5L0E A;  4ZG7 A;  4CYS A;  3SZZ A;  3WAX A;  5L0B A;  1N2K A;  5K4P A;  2GSN A;  2W8D A;  1ALH A;  1ALK A;  3TG0 A;  2GSU A;  2W5Q A;  1KH5 A;  3Q3Q A;  2IFY A;  2W5V A;  4GTX A;  4CXU A;  4LRE A;  4B56 A;  3WAY A;  5KXA A;  2W8S A;  2W5W A;  4LQY A;  3T02 A;  4LRC A;  3B5Q A;  4QAX A;  1KHK A;  3IGY B;  1AJB A;  1K7H A;  2XR9 A;  2W5X A;  5LQQ A;  3IGZ B;  1ZEF A;  3BDF A;  2G9Y A;  1P49 A;  3BDH A;  1ALI A;  4ZGA A;  3M8Y A;  5HRT A;  1SHQ A;  2W5S A;  1E2S P;  3UN2 A;  2IUC B;  4MIV A;  4UPI A;  5GOV A;  5LRM A;  4LR7 A;  3OT9 A;  4LRB A;  1ANI A;  5DLW A;  1ANJ A;  4CYR A;  1KH9 A;  2IUC A;  2X98 A;  1ZEB A;  3NKR A;  1AJD A;  1E3C P;  5TJ3 A;  2RH6 A;  2VQR A;  5LRN A;  1KH7 A;  4YR1 A;  5IJS A;  4KAY A;  3M8W A;  5AJ9 A;  2XRG A;  4UPL A;  1ED8 A;  2ANH A;  3NKN A;  1HDH A;  4LRF A;  1ELX A;  1HQA A;  2D1G A;  3NKQ A;  4LRA A;  4UOR A;  1URB A;  3SZY A;  4GTY A;  3BDG B;  3WAV A;  3IDD A;  3T00 A;  1KHN A;  3UN5 A;  3LXQ A;  2GA3 A;  3ED4 A;  5EGH A;  2GSO A;  1EW8 A;  3TWZ A;  1ZED A;  1O98 A;  3WBH A;  3KD8 A;  1FSU A;  4FDJ A;  1EJJ A;  4N7T A;  5DLT A;  1URA A;  3A52 A;  2W5R A;  3UNY A;  1ED9 A;  3NVL A;  5EGE A;  4NWX A;  1Y7A A;  3CMR A;  1Y6V A;  4KAV A;  4GTW A;  3MK2 A;  4LR8 A;  3NKM A;  4NWJ A;  4KJD A;  3NKP A;  1ALJ A;  4UOO A;  1KHL A;  4UPH A;  4UOP A;  4GTZ A;  4FDI A;  1KHJ A;  3NKO A;  4LR9 A;  1EQJ A;  5DLV A;  3UO0 A;  4TN0 A;  5INH A;  1E33 P;  1N2L A;  1EW2 A;  4KM4 A;  5LIA A;  3E2D A;  2GLQ A;  3TX0 A;  1O99 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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