1HJKA

Alkaline phosphatase mutant h331q
Total Genus 152
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
152
Knots found
sequence length
449
structure length
448
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDQAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Trapping and visualization of a covalent enzyme-phosphate intermediate.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 152
structure length 448
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1997-05-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hjkA00
3BDHA 1HJKA 1ZEDA 3NKQA 1ED8A 1AJDA 1AJBA 4GTZA 4FDJA 3WBHA 2W5SA 5LQQA 1URAA 5C66A 2GSOA 1Y7AA 4UPLA 3M8WA 1Y6VA 1KH5A 4FDIA 4UPIA 4MHXA 4LR2A 1ZEFA 1SHQA 4CXSA 1HQAA 1ALKA 2VQRA 4KAYA 3E2DA 1ED9A 4CXKA 2W8SA 1ANIA 5K4PA 1KHKA 4QAXA 4ZGAA 3WAXA 2W5VA 3UO0A 4GTYA 3MK1A 4NWJA 5HRTA 1E1ZP 3LXQA 4LRAA 3DPCA 4LQYA 4UPKA 2ZKTA 3M8YA 3NKNA 4UOPA 3IGYB 4LRFA 4CYSA 1EJJA 5LRMA 1KH7A 3CMRA 4KM4A 3A52A 4KJGA 4N7TA 3T01A 3MK0A 4UOOA 2X98A 3UN2A 3SZYA 1KH9A 5INHA 3Q3QA 1ALHA 1E3CP 3UN3A 1EQJA 1EW2A 4UORA 4CYRA 2RH6A 2W5QA 4UPHA 2W5XA 3OT9A 1O99A 3T02A 1EI6A 1KHNA 5L0BA 4MIVA 3WAYA 3BDGB 3M8ZA 2IUCB 5DLTA 5DLVA 1P49A 3NKPA 2W5WA 4NWXA 2W8DA 4GTXA 1AUKA 2IUCA 1ALIA 4LREA 3NKMA 3UN5A 3KD8A 1AJCA 2QZUA 1N2LA 1URBA 2G9YA 1KH4A 4LRCA 5LIAA 2GSNA 1B8JA 3IGZB 3TX0A 3ED4A 1EW9A 1ZEBA 3DYCA 3NKRA 4KJDA 1ELZA 4ZG9A 5IJSA 4ZG7A 2W5RA 4CXUA 1SHNA 5GOVA 4LR7A 1O98A 1KHLA 2D1GA 1EW8A 2GSUA 3B5QA 5AJ9A 5L0EA 2W5TA 4GTWA 3T00A 5DLWA 2XRGA 4KAVA 3WAVA 4ZG6A 1E2SP 4MY4A 2IFYA 3BDFA 1K7HA 1ELYA 1E33P 4LRBA 4LRDA 3M7VA 3IDDA 1N2KA 3UNYA 5L0KA 2XR9A 1HDHA 2GA3A 5TJ3A 1ANJA 2ANHA 1ALJA 3TG0A 3TWZA 5KXAA 5IJQA 3NKOA 1AJAA 5EGHA 1KHJA 3MK2A 1ELXA 3BDGA 5LRNA 3NVLA 4YR1A 5EGEA 4LR9A 4TN0A 5GRRA 3SZZA 2GLQA 3WAWA 1FSUA 4LR8A 4B56A
chains in the Genus database with same CATH superfamily
3BDHA 1HJKA 1ZEDA 3NKQA 1ED8A 1AJDA 1AJBA 4GTZA 4FDJA 3WBHA 2W5SA 5LQQA 1URAA 5C66A 2GSOA 1Y7AA 4UPLA 3M8WA 1Y6VA 1KH5A 4FDIA 4UPIA 4MHXA 4LR2A 1ZEFA 1SHQA 4CXSA 1HQAA 1ALKA 2VQRA 4KAYA 3E2DA 1ED9A 4CXKA 2W8SA 1ANIA 5K4PA 1KHKA 4QAXA 4ZGAA 3WAXA 2W5VA 3UO0A 4GTYA 3MK1A 4NWJA 5HRTA 1E1ZP 3LXQA 4LRAA 3DPCA 4LQYA 4UPKA 2ZKTA 3M8YA 3NKNA 4UOPA 3IGYB 4LRFA 4CYSA 1EJJA 5LRMA 1KH7A 3CMRA 4KM4A 3A52A 4KJGA 4N7TA 3T01A 3MK0A 4UOOA 2X98A 3UN2A 3SZYA 1KH9A 5INHA 3Q3QA 1ALHA 1E3CP 3UN3A 1EQJA 1EW2A 4UORA 4CYRA 2RH6A 2W5QA 4UPHA 2W5XA 3OT9A 1O99A 3T02A 1EI6A 1KHNA 5L0BA 4MIVA 3WAYA 3BDGB 3M8ZA 2IUCB 5DLTA 5DLVA 1P49A 3NKPA 2W5WA 4NWXA 2W8DA 4GTXA 1AUKA 2IUCA 1ALIA 4LREA 3NKMA 3UN5A 3KD8A 1AJCA 2QZUA 1N2LA 1URBA 2G9YA 1KH4A 4LRCA 5LIAA 2GSNA 1B8JA 3IGZB 3TX0A 3ED4A 1EW9A 1ZEBA 3DYCA 3NKRA 4KJDA 1ELZA 4ZG9A 5IJSA 4ZG7A 2W5RA 4CXUA 1SHNA 5GOVA 4LR7A 1O98A 1KHLA 2D1GA 1EW8A 2GSUA 3B5QA 5AJ9A 5L0EA 2W5TA 4GTWA 3T00A 5DLWA 2XRGA 4KAVA 3WAVA 4ZG6A 1E2SP 4MY4A 2IFYA 3BDFA 1K7HA 1ELYA 1E33P 4LRBA 4LRDA 3M7VA 3IDDA 1N2KA 3UNYA 5L0KA 2XR9A 1HDHA 2GA3A 5TJ3A 1ANJA 2ANHA 1ALJA 3TG0A 3TWZA 5KXAA 5IJQA 3NKOA 1AJAA 5EGHA 1KHJA 3MK2A 1ELXA 3BDGA 5LRNA 3NVLA 4YR1A 5EGEA 4LR9A 4TN0A 5GRRA 3SZZA 2GLQA 3WAWA 1FSUA 4LR8A 4B56A
chains in the Genus database with same CATH topology
3BDHA 1HJKA 1ZEDA 3NKQA 1ED8A 1AJDA 1AJBA 4GTZA 4FDJA 3WBHA 2W5SA 5LQQA 1URAA 5C66A 2GSOA 1Y7AA 4UPLA 3M8WA 1Y6VA 1KH5A 4FDIA 4UPIA 4MHXA 4LR2A 1ZEFA 1SHQA 4CXSA 1HQAA 1ALKA 2VQRA 4KAYA 3E2DA 1ED9A 4CXKA 2W8SA 1ANIA 5K4PA 1KHKA 4QAXA 4ZGAA 3WAXA 2W5VA 3UO0A 4GTYA 3MK1A 4NWJA 5HRTA 1E1ZP 3LXQA 4LRAA 3DPCA 4LQYA 4UPKA 2ZKTA 3M8YA 3NKNA 4UOPA 3IGYB 4LRFA 4CYSA 1EJJA 5LRMA 1KH7A 3CMRA 4KM4A 3A52A 4KJGA 4N7TA 3T01A 3MK0A 4UOOA 2X98A 3UN2A 3SZYA 1KH9A 5INHA 3Q3QA 1ALHA 1E3CP 3UN3A 1EQJA 1EW2A 4UORA 4CYRA 2RH6A 2W5QA 4UPHA 2W5XA 3OT9A 1O99A 3T02A 1EI6A 1KHNA 5L0BA 4MIVA 3WAYA 3BDGB 3M8ZA 2IUCB 5DLTA 5DLVA 1P49A 3NKPA 2W5WA 4NWXA 2W8DA 4GTXA 1AUKA 2IUCA 1ALIA 4LREA 3NKMA 3UN5A 3KD8A 1AJCA 2QZUA 1N2LA 1URBA 2G9YA 1KH4A 4LRCA 5LIAA 2GSNA 1B8JA 3IGZB 3TX0A 3ED4A 1EW9A 1ZEBA 3DYCA 3NKRA 4KJDA 1ELZA 4ZG9A 5IJSA 4ZG7A 2W5RA 4CXUA 1SHNA 5GOVA 4LR7A 1O98A 1KHLA 2D1GA 1EW8A 2GSUA 3B5QA 5AJ9A 5L0EA 2W5TA 4GTWA 3T00A 5DLWA 2XRGA 4KAVA 3WAVA 4ZG6A 1E2SP 4MY4A 2IFYA 3BDFA 1K7HA 1ELYA 1E33P 4LRBA 4LRDA 3M7VA 3IDDA 1N2KA 3UNYA 5L0KA 2XR9A 1HDHA 2GA3A 5TJ3A 1ANJA 2ANHA 1ALJA 3TG0A 3TWZA 5KXAA 5IJQA 3NKOA 1AJAA 5EGHA 1KHJA 3MK2A 1ELXA 3BDGA 5LRNA 3NVLA 4YR1A 5EGEA 4LR9A 4TN0A 5GRRA 3SZZA 2GLQA 3WAWA 1FSUA 4LR8A 4B56A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDH A;  1HJK A;  1ZED A;  3NKQ A;  1ED8 A;  1AJD A;  1AJB A;  4GTZ A;  4FDJ A;  3WBH A;  2W5S A;  5LQQ A;  1URA A;  5C66 A;  2GSO A;  1Y7A A;  4UPL A;  3M8W A;  1Y6V A;  1KH5 A;  4FDI A;  4UPI A;  4MHX A;  4LR2 A;  1ZEF A;  1SHQ A;  4CXS A;  1HQA A;  1ALK A;  2VQR A;  4KAY A;  3E2D A;  1ED9 A;  4CXK A;  2W8S A;  1ANI A;  5K4P A;  1KHK A;  4QAX A;  4ZGA A;  3WAX A;  2W5V A;  3UO0 A;  4GTY A;  3MK1 A;  4NWJ A;  5HRT A;  1E1Z P;  3LXQ A;  4LRA A;  3DPC A;  4LQY A;  4UPK A;  2ZKT A;  3M8Y A;  3NKN A;  4UOP A;  3IGY B;  4LRF A;  4CYS A;  1EJJ A;  5LRM A;  1KH7 A;  3CMR A;  4KM4 A;  3A52 A;  4KJG A;  4N7T A;  3T01 A;  3MK0 A;  4UOO A;  2X98 A;  3UN2 A;  3SZY A;  1KH9 A;  5INH A;  3Q3Q A;  1ALH A;  1E3C P;  3UN3 A;  1EQJ A;  1EW2 A;  4UOR A;  4CYR A;  2RH6 A;  2W5Q A;  4UPH A;  2W5X A;  3OT9 A;  1O99 A;  3T02 A;  1EI6 A;  1KHN A;  5L0B A;  4MIV A;  3WAY A;  3BDG B;  3M8Z A;  2IUC B;  5DLT A;  5DLV A;  1P49 A;  3NKP A;  2W5W A;  4NWX A;  2W8D A;  4GTX A;  1AUK A;  2IUC A;  1ALI A;  4LRE A;  3NKM A;  3UN5 A;  3KD8 A;  1AJC A;  2QZU A;  1N2L A;  1URB A;  2G9Y A;  1KH4 A;  4LRC A;  5LIA A;  2GSN A;  1B8J A;  3IGZ B;  3TX0 A;  3ED4 A;  1EW9 A;  1ZEB A;  3DYC A;  3NKR A;  4KJD A;  1ELZ A;  4ZG9 A;  5IJS A;  4ZG7 A;  2W5R A;  4CXU A;  1SHN A;  5GOV A;  4LR7 A;  1O98 A;  1KHL A;  2D1G A;  1EW8 A;  2GSU A;  3B5Q A;  5AJ9 A;  5L0E A;  2W5T A;  4GTW A;  3T00 A;  5DLW A;  2XRG A;  4KAV A;  3WAV A;  4ZG6 A;  1E2S P;  4MY4 A;  2IFY A;  3BDF A;  1K7H A;  1ELY A;  1E33 P;  4LRB A;  4LRD A;  3M7V A;  3IDD A;  1N2K A;  3UNY A;  5L0K A;  2XR9 A;  1HDH A;  2GA3 A;  5TJ3 A;  1ANJ A;  2ANH A;  1ALJ A;  3TG0 A;  3TWZ A;  5KXA A;  5IJQ A;  3NKO A;  1AJA A;  5EGH A;  1KHJ A;  3MK2 A;  1ELX A;  3BDG A;  5LRN A;  3NVL A;  4YR1 A;  5EGE A;  4LR9 A;  4TN0 A;  5GRR A;  3SZZ A;  2GLQ A;  3WAW A;  1FSU A;  4LR8 A;  4B56 A; 
#chains in the Genus database with same CATH topology
 3BDH A;  1HJK A;  1ZED A;  3NKQ A;  1ED8 A;  1AJD A;  1AJB A;  4GTZ A;  4FDJ A;  3WBH A;  2W5S A;  5LQQ A;  1URA A;  5C66 A;  2GSO A;  1Y7A A;  4UPL A;  3M8W A;  1Y6V A;  1KH5 A;  4FDI A;  4UPI A;  4MHX A;  4LR2 A;  1ZEF A;  1SHQ A;  4CXS A;  1HQA A;  1ALK A;  2VQR A;  4KAY A;  3E2D A;  1ED9 A;  4CXK A;  2W8S A;  1ANI A;  5K4P A;  1KHK A;  4QAX A;  4ZGA A;  3WAX A;  2W5V A;  3UO0 A;  4GTY A;  3MK1 A;  4NWJ A;  5HRT A;  1E1Z P;  3LXQ A;  4LRA A;  3DPC A;  4LQY A;  4UPK A;  2ZKT A;  3M8Y A;  3NKN A;  4UOP A;  3IGY B;  4LRF A;  4CYS A;  1EJJ A;  5LRM A;  1KH7 A;  3CMR A;  4KM4 A;  3A52 A;  4KJG A;  4N7T A;  3T01 A;  3MK0 A;  4UOO A;  2X98 A;  3UN2 A;  3SZY A;  1KH9 A;  5INH A;  3Q3Q A;  1ALH A;  1E3C P;  3UN3 A;  1EQJ A;  1EW2 A;  4UOR A;  4CYR A;  2RH6 A;  2W5Q A;  4UPH A;  2W5X A;  3OT9 A;  1O99 A;  3T02 A;  1EI6 A;  1KHN A;  5L0B A;  4MIV A;  3WAY A;  3BDG B;  3M8Z A;  2IUC B;  5DLT A;  5DLV A;  1P49 A;  3NKP A;  2W5W A;  4NWX A;  2W8D A;  4GTX A;  1AUK A;  2IUC A;  1ALI A;  4LRE A;  3NKM A;  3UN5 A;  3KD8 A;  1AJC A;  2QZU A;  1N2L A;  1URB A;  2G9Y A;  1KH4 A;  4LRC A;  5LIA A;  2GSN A;  1B8J A;  3IGZ B;  3TX0 A;  3ED4 A;  1EW9 A;  1ZEB A;  3DYC A;  3NKR A;  4KJD A;  1ELZ A;  4ZG9 A;  5IJS A;  4ZG7 A;  2W5R A;  4CXU A;  1SHN A;  5GOV A;  4LR7 A;  1O98 A;  1KHL A;  2D1G A;  1EW8 A;  2GSU A;  3B5Q A;  5AJ9 A;  5L0E A;  2W5T A;  4GTW A;  3T00 A;  5DLW A;  2XRG A;  4KAV A;  3WAV A;  4ZG6 A;  1E2S P;  4MY4 A;  2IFY A;  3BDF A;  1K7H A;  1ELY A;  1E33 P;  4LRB A;  4LRD A;  3M7V A;  3IDD A;  1N2K A;  3UNY A;  5L0K A;  2XR9 A;  1HDH A;  2GA3 A;  5TJ3 A;  1ANJ A;  2ANH A;  1ALJ A;  3TG0 A;  3TWZ A;  5KXA A;  5IJQ A;  3NKO A;  1AJA A;  5EGH A;  1KHJ A;  3MK2 A;  1ELX A;  3BDG A;  5LRN A;  3NVL A;  4YR1 A;  5EGE A;  4LR9 A;  4TN0 A;  5GRR A;  3SZZ A;  2GLQ A;  3WAW A;  1FSU A;  4LR8 A;  4B56 A; 
#chains in the Genus database with same CATH homology
 3BDH A;  1HJK A;  1ZED A;  3NKQ A;  1ED8 A;  1AJD A;  1AJB A;  4GTZ A;  4FDJ A;  3WBH A;  2W5S A;  5LQQ A;  1URA A;  5C66 A;  2GSO A;  1Y7A A;  4UPL A;  3M8W A;  1Y6V A;  1KH5 A;  4FDI A;  4UPI A;  4MHX A;  4LR2 A;  1ZEF A;  1SHQ A;  4CXS A;  1HQA A;  1ALK A;  2VQR A;  4KAY A;  3E2D A;  1ED9 A;  4CXK A;  2W8S A;  1ANI A;  5K4P A;  1KHK A;  4QAX A;  4ZGA A;  3WAX A;  2W5V A;  3UO0 A;  4GTY A;  3MK1 A;  4NWJ A;  5HRT A;  1E1Z P;  3LXQ A;  4LRA A;  3DPC A;  4LQY A;  4UPK A;  2ZKT A;  3M8Y A;  3NKN A;  4UOP A;  3IGY B;  4LRF A;  4CYS A;  1EJJ A;  5LRM A;  1KH7 A;  3CMR A;  4KM4 A;  3A52 A;  4KJG A;  4N7T A;  3T01 A;  3MK0 A;  4UOO A;  2X98 A;  3UN2 A;  3SZY A;  1KH9 A;  5INH A;  3Q3Q A;  1ALH A;  1E3C P;  3UN3 A;  1EQJ A;  1EW2 A;  4UOR A;  4CYR A;  2RH6 A;  2W5Q A;  4UPH A;  2W5X A;  3OT9 A;  1O99 A;  3T02 A;  1EI6 A;  1KHN A;  5L0B A;  4MIV A;  3WAY A;  3BDG B;  3M8Z A;  2IUC B;  5DLT A;  5DLV A;  1P49 A;  3NKP A;  2W5W A;  4NWX A;  2W8D A;  4GTX A;  1AUK A;  2IUC A;  1ALI A;  4LRE A;  3NKM A;  3UN5 A;  3KD8 A;  1AJC A;  2QZU A;  1N2L A;  1URB A;  2G9Y A;  1KH4 A;  4LRC A;  5LIA A;  2GSN A;  1B8J A;  3IGZ B;  3TX0 A;  3ED4 A;  1EW9 A;  1ZEB A;  3DYC A;  3NKR A;  4KJD A;  1ELZ A;  4ZG9 A;  5IJS A;  4ZG7 A;  2W5R A;  4CXU A;  1SHN A;  5GOV A;  4LR7 A;  1O98 A;  1KHL A;  2D1G A;  1EW8 A;  2GSU A;  3B5Q A;  5AJ9 A;  5L0E A;  2W5T A;  4GTW A;  3T00 A;  5DLW A;  2XRG A;  4KAV A;  3WAV A;  4ZG6 A;  1E2S P;  4MY4 A;  2IFY A;  3BDF A;  1K7H A;  1ELY A;  1E33 P;  4LRB A;  4LRD A;  3M7V A;  3IDD A;  1N2K A;  3UNY A;  5L0K A;  2XR9 A;  1HDH A;  2GA3 A;  5TJ3 A;  1ANJ A;  2ANH A;  1ALJ A;  3TG0 A;  3TWZ A;  5KXA A;  5IJQ A;  3NKO A;  1AJA A;  5EGH A;  1KHJ A;  3MK2 A;  1ELX A;  3BDG A;  5LRN A;  3NVL A;  4YR1 A;  5EGE A;  4LR9 A;  4TN0 A;  5GRR A;  3SZZ A;  2GLQ A;  3WAW A;  1FSU A;  4LR8 A;  4B56 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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