1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
source organism Escherichia coli
total genus 167
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
5LIAA 1URAA 3SZZA 1EW2A 4LRAA 5IJQA 5INHA 4TN0A 4MIVA 1HQAA 4MY4A 4UOPA 4LR2A 3WAYA 4LRFA 1ZEFA 5EGHA 2IUCA 3ED4A 3MK2A 3NKMA 4LRBA 1B8JA 3BDGA 3CMRA 1ALHA 4UPIA 5K4PA 3T02A 1EW8A 4CXUA 4UPLA 1ED9A 3BDFA 1E33P 5GRRA 2W8SA 1ZEBA 5EGEA 3NKPA 2W5VA 2W5WA 4UPHA 1SHQA 1KHLA 1E3CP 1E1ZP 1KHJA 1AJDA 1KHKA 4UORA 1P49A 3KD8A 2QZUA 3M8YA 4NWJA 4CXKA 4ZG9A 4QAXA 2RH6A 2XR9A 4LRDA 3T01A 1URBA 1ALKA 1KHNA 1Y6VA 1EJJA 3Q3QA 4N7TA 5DLVA 1E2SP 3WBHA 4KJDA 1ANIA 3NKQA 3MK1A 3TX0A 2W5SA 1EI6A 2GLQA 4ZG6A 1KH5A 3NVLA 1N2LA 2IUCB 3LXQA 4KJGA 2D1GA 2W5XA 2ZKTA 1ANJA 1HDHA 5L0KA 3SZYA 2VQRA 4CXSA 1AJCA 1ELXA 3TG0A 1EW9A 1K7HA 4FDJA 2GSUA 2GA3A 1ELYA 3NKOA 3DYCA 3IGYB 4NWXA 2XRGA 3T00A 2G9YA 4LR8A 5GOVA 5LRMA 1O98A 4KAYA 3M8WA 4UOOA 5LQQA 2ANHA 4FDIA 2GSNA 1ED8A 3M8ZA 3UN3A 3UO0A 5AJ9A 3NKNA 5C66A 3WAWA 2X98A 3BDGB 5KXAA 1KH9A 2W5QA 4B56A 4GTWA 4CYSA 4GTYA 3UNYA 1KH7A 4ZGAA 4LQYA 1ELZA 3E2DA 3M7VA 2GSOA 5L0EA 4LREA 4KM4A 1AUKA 1N2KA 3UN5A 4KAVA 4LR9A 2IFYA 3WAVA 1ALJA 5DLWA 1AJBA 1ZEDA 1FSUA 1AJAA 3UN2A 2W5TA 5L0BA 3TWZA 1KH4A 4LRCA 4CYRA 4LR7A 3BDHA 3OT9A 4YR1A 1EQJA 1Y7AA 5DLTA 4ZG7A 3DPCA 2W5RA 5IJSA 5HRTA 3MK0A 1ALIA 3IGZB 3B5QA 3WAXA 3IDDA 4MHXA 3NKRA 3A52A 1HJKA 1O99A 4GTZA 1SHNA 2W8DA 5LRNA 4GTXA 4UPKA 5TJ3A
chains in the Genus database with same CATH superfamily
5LIAA 1URAA 3SZZA 1EW2A 4LRAA 5IJQA 5INHA 4TN0A 4MIVA 1HQAA 4MY4A 4UOPA 4LR2A 3WAYA 4LRFA 1ZEFA 5EGHA 2IUCA 3ED4A 3MK2A 3NKMA 4LRBA 1B8JA 3BDGA 3CMRA 1ALHA 4UPIA 5K4PA 3T02A 1EW8A 4CXUA 4UPLA 1ED9A 3BDFA 1E33P 5GRRA 2W8SA 1ZEBA 5EGEA 3NKPA 2W5VA 2W5WA 4UPHA 1SHQA 1KHLA 1E3CP 1E1ZP 1KHJA 1AJDA 1KHKA 4UORA 1P49A 3KD8A 2QZUA 3M8YA 4NWJA 4CXKA 4ZG9A 4QAXA 2RH6A 2XR9A 4LRDA 3T01A 1URBA 1ALKA 1KHNA 1Y6VA 1EJJA 3Q3QA 4N7TA 5DLVA 1E2SP 3WBHA 4KJDA 1ANIA 3NKQA 3MK1A 3TX0A 2W5SA 1EI6A 2GLQA 4ZG6A 1KH5A 3NVLA 1N2LA 2IUCB 3LXQA 4KJGA 2D1GA 2W5XA 2ZKTA 1ANJA 1HDHA 5L0KA 3SZYA 2VQRA 4CXSA 1AJCA 1ELXA 3TG0A 1EW9A 1K7HA 4FDJA 2GSUA 2GA3A 1ELYA 3NKOA 3DYCA 3IGYB 4NWXA 2XRGA 3T00A 2G9YA 4LR8A 5GOVA 5LRMA 1O98A 4KAYA 3M8WA 4UOOA 5LQQA 2ANHA 4FDIA 2GSNA 1ED8A 3M8ZA 3UN3A 3UO0A 5AJ9A 3NKNA 5C66A 3WAWA 2X98A 3BDGB 5KXAA 1KH9A 2W5QA 4B56A 4GTWA 4CYSA 4GTYA 3UNYA 1KH7A 4ZGAA 4LQYA 1ELZA 3E2DA 3M7VA 2GSOA 5L0EA 4LREA 4KM4A 1AUKA 1N2KA 3UN5A 4KAVA 4LR9A 2IFYA 3WAVA 1ALJA 5DLWA 1AJBA 1ZEDA 1FSUA 1AJAA 3UN2A 2W5TA 5L0BA 3TWZA 1KH4A 4LRCA 4CYRA 4LR7A 3BDHA 3OT9A 4YR1A 1EQJA 1Y7AA 5DLTA 4ZG7A 3DPCA 2W5RA 5IJSA 5HRTA 3MK0A 1ALIA 3IGZB 3B5QA 3WAXA 3IDDA 4MHXA 3NKRA 3A52A 1HJKA 1O99A 4GTZA 1SHNA 2W8DA 5LRNA 4GTXA 4UPKA 5TJ3A
chains in the Genus database with same CATH topology
5LIAA 1URAA 3SZZA 1EW2A 4LRAA 5IJQA 5INHA 4TN0A 4MIVA 1HQAA 4MY4A 4UOPA 4LR2A 3WAYA 4LRFA 1ZEFA 5EGHA 2IUCA 3ED4A 3MK2A 3NKMA 4LRBA 1B8JA 3BDGA 3CMRA 1ALHA 4UPIA 5K4PA 3T02A 1EW8A 4CXUA 4UPLA 1ED9A 3BDFA 1E33P 5GRRA 2W8SA 1ZEBA 5EGEA 3NKPA 2W5VA 2W5WA 4UPHA 1SHQA 1KHLA 1E3CP 1E1ZP 1KHJA 1AJDA 1KHKA 4UORA 1P49A 3KD8A 2QZUA 3M8YA 4NWJA 4CXKA 4ZG9A 4QAXA 2RH6A 2XR9A 4LRDA 3T01A 1URBA 1ALKA 1KHNA 1Y6VA 1EJJA 3Q3QA 4N7TA 5DLVA 1E2SP 3WBHA 4KJDA 1ANIA 3NKQA 3MK1A 3TX0A 2W5SA 1EI6A 2GLQA 4ZG6A 1KH5A 3NVLA 1N2LA 2IUCB 3LXQA 4KJGA 2D1GA 2W5XA 2ZKTA 1ANJA 1HDHA 5L0KA 3SZYA 2VQRA 4CXSA 1AJCA 1ELXA 3TG0A 1EW9A 1K7HA 4FDJA 2GSUA 2GA3A 1ELYA 3NKOA 3DYCA 3IGYB 4NWXA 2XRGA 3T00A 2G9YA 4LR8A 5GOVA 5LRMA 1O98A 4KAYA 3M8WA 4UOOA 5LQQA 2ANHA 4FDIA 2GSNA 1ED8A 3M8ZA 3UN3A 3UO0A 5AJ9A 3NKNA 5C66A 3WAWA 2X98A 3BDGB 5KXAA 1KH9A 2W5QA 4B56A 4GTWA 4CYSA 4GTYA 3UNYA 1KH7A 4ZGAA 4LQYA 1ELZA 3E2DA 3M7VA 2GSOA 5L0EA 4LREA 4KM4A 1AUKA 1N2KA 3UN5A 4KAVA 4LR9A 2IFYA 3WAVA 1ALJA 5DLWA 1AJBA 1ZEDA 1FSUA 1AJAA 3UN2A 2W5TA 5L0BA 3TWZA 1KH4A 4LRCA 4CYRA 4LR7A 3BDHA 3OT9A 4YR1A 1EQJA 1Y7AA 5DLTA 4ZG7A 3DPCA 2W5RA 5IJSA 5HRTA 3MK0A 1ALIA 3IGZB 3B5QA 3WAXA 3IDDA 4MHXA 3NKRA 3A52A 1HJKA 1O99A 4GTZA 1SHNA 2W8DA 5LRNA 4GTXA 4UPKA 5TJ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LIA A;  1URA A;  3SZZ A;  1EW2 A;  4LRA A;  5IJQ A;  5INH A;  4TN0 A;  4MIV A;  1HQA A;  4MY4 A;  4UOP A;  4LR2 A;  3WAY A;  4LRF A;  1ZEF A;  5EGH A;  2IUC A;  3ED4 A;  3MK2 A;  3NKM A;  4LRB A;  1B8J A;  3BDG A;  3CMR A;  1ALH A;  4UPI A;  5K4P A;  3T02 A;  1EW8 A;  4CXU A;  4UPL A;  1ED9 A;  3BDF A;  1E33 P;  5GRR A;  2W8S A;  1ZEB A;  5EGE A;  3NKP A;  2W5V A;  2W5W A;  4UPH A;  1SHQ A;  1KHL A;  1E3C P;  1E1Z P;  1KHJ A;  1AJD A;  1KHK A;  4UOR A;  1P49 A;  3KD8 A;  2QZU A;  3M8Y A;  4NWJ A;  4CXK A;  4ZG9 A;  4QAX A;  2RH6 A;  2XR9 A;  4LRD A;  3T01 A;  1URB A;  1ALK A;  1KHN A;  1Y6V A;  1EJJ A;  3Q3Q A;  4N7T A;  5DLV A;  1E2S P;  3WBH A;  4KJD A;  1ANI A;  3NKQ A;  3MK1 A;  3TX0 A;  2W5S A;  1EI6 A;  2GLQ A;  4ZG6 A;  1KH5 A;  3NVL A;  1N2L A;  2IUC B;  3LXQ A;  4KJG A;  2D1G A;  2W5X A;  2ZKT A;  1ANJ A;  1HDH A;  5L0K A;  3SZY A;  2VQR A;  4CXS A;  1AJC A;  1ELX A;  3TG0 A;  1EW9 A;  1K7H A;  4FDJ A;  2GSU A;  2GA3 A;  1ELY A;  3NKO A;  3DYC A;  3IGY B;  4NWX A;  2XRG A;  3T00 A;  2G9Y A;  4LR8 A;  5GOV A;  5LRM A;  1O98 A;  4KAY A;  3M8W A;  4UOO A;  5LQQ A;  2ANH A;  4FDI A;  2GSN A;  1ED8 A;  3M8Z A;  3UN3 A;  3UO0 A;  5AJ9 A;  3NKN A;  5C66 A;  3WAW A;  2X98 A;  3BDG B;  5KXA A;  1KH9 A;  2W5Q A;  4B56 A;  4GTW A;  4CYS A;  4GTY A;  3UNY A;  1KH7 A;  4ZGA A;  4LQY A;  1ELZ A;  3E2D A;  3M7V A;  2GSO A;  5L0E A;  4LRE A;  4KM4 A;  1AUK A;  1N2K A;  3UN5 A;  4KAV A;  4LR9 A;  2IFY A;  3WAV A;  1ALJ A;  5DLW A;  1AJB A;  1ZED A;  1FSU A;  1AJA A;  3UN2 A;  2W5T A;  5L0B A;  3TWZ A;  1KH4 A;  4LRC A;  4CYR A;  4LR7 A;  3BDH A;  3OT9 A;  4YR1 A;  1EQJ A;  1Y7A A;  5DLT A;  4ZG7 A;  3DPC A;  2W5R A;  5IJS A;  5HRT A;  3MK0 A;  1ALI A;  3IGZ B;  3B5Q A;  3WAX A;  3IDD A;  4MHX A;  3NKR A;  3A52 A;  1HJK A;  1O99 A;  4GTZ A;  1SHN A;  2W8D A;  5LRN A;  4GTX A;  4UPK A;  5TJ3 A; 
#chains in the Genus database with same CATH topology
 5LIA A;  1URA A;  3SZZ A;  1EW2 A;  4LRA A;  5IJQ A;  5INH A;  4TN0 A;  4MIV A;  1HQA A;  4MY4 A;  4UOP A;  4LR2 A;  3WAY A;  4LRF A;  1ZEF A;  5EGH A;  2IUC A;  3ED4 A;  3MK2 A;  3NKM A;  4LRB A;  1B8J A;  3BDG A;  3CMR A;  1ALH A;  4UPI A;  5K4P A;  3T02 A;  1EW8 A;  4CXU A;  4UPL A;  1ED9 A;  3BDF A;  1E33 P;  5GRR A;  2W8S A;  1ZEB A;  5EGE A;  3NKP A;  2W5V A;  2W5W A;  4UPH A;  1SHQ A;  1KHL A;  1E3C P;  1E1Z P;  1KHJ A;  1AJD A;  1KHK A;  4UOR A;  1P49 A;  3KD8 A;  2QZU A;  3M8Y A;  4NWJ A;  4CXK A;  4ZG9 A;  4QAX A;  2RH6 A;  2XR9 A;  4LRD A;  3T01 A;  1URB A;  1ALK A;  1KHN A;  1Y6V A;  1EJJ A;  3Q3Q A;  4N7T A;  5DLV A;  1E2S P;  3WBH A;  4KJD A;  1ANI A;  3NKQ A;  3MK1 A;  3TX0 A;  2W5S A;  1EI6 A;  2GLQ A;  4ZG6 A;  1KH5 A;  3NVL A;  1N2L A;  2IUC B;  3LXQ A;  4KJG A;  2D1G A;  2W5X A;  2ZKT A;  1ANJ A;  1HDH A;  5L0K A;  3SZY A;  2VQR A;  4CXS A;  1AJC A;  1ELX A;  3TG0 A;  1EW9 A;  1K7H A;  4FDJ A;  2GSU A;  2GA3 A;  1ELY A;  3NKO A;  3DYC A;  3IGY B;  4NWX A;  2XRG A;  3T00 A;  2G9Y A;  4LR8 A;  5GOV A;  5LRM A;  1O98 A;  4KAY A;  3M8W A;  4UOO A;  5LQQ A;  2ANH A;  4FDI A;  2GSN A;  1ED8 A;  3M8Z A;  3UN3 A;  3UO0 A;  5AJ9 A;  3NKN A;  5C66 A;  3WAW A;  2X98 A;  3BDG B;  5KXA A;  1KH9 A;  2W5Q A;  4B56 A;  4GTW A;  4CYS A;  4GTY A;  3UNY A;  1KH7 A;  4ZGA A;  4LQY A;  1ELZ A;  3E2D A;  3M7V A;  2GSO A;  5L0E A;  4LRE A;  4KM4 A;  1AUK A;  1N2K A;  3UN5 A;  4KAV A;  4LR9 A;  2IFY A;  3WAV A;  1ALJ A;  5DLW A;  1AJB A;  1ZED A;  1FSU A;  1AJA A;  3UN2 A;  2W5T A;  5L0B A;  3TWZ A;  1KH4 A;  4LRC A;  4CYR A;  4LR7 A;  3BDH A;  3OT9 A;  4YR1 A;  1EQJ A;  1Y7A A;  5DLT A;  4ZG7 A;  3DPC A;  2W5R A;  5IJS A;  5HRT A;  3MK0 A;  1ALI A;  3IGZ B;  3B5Q A;  3WAX A;  3IDD A;  4MHX A;  3NKR A;  3A52 A;  1HJK A;  1O99 A;  4GTZ A;  1SHN A;  2W8D A;  5LRN A;  4GTX A;  4UPK A;  5TJ3 A; 
#chains in the Genus database with same CATH homology
 5LIA A;  1URA A;  3SZZ A;  1EW2 A;  4LRA A;  5IJQ A;  5INH A;  4TN0 A;  4MIV A;  1HQA A;  4MY4 A;  4UOP A;  4LR2 A;  3WAY A;  4LRF A;  1ZEF A;  5EGH A;  2IUC A;  3ED4 A;  3MK2 A;  3NKM A;  4LRB A;  1B8J A;  3BDG A;  3CMR A;  1ALH A;  4UPI A;  5K4P A;  3T02 A;  1EW8 A;  4CXU A;  4UPL A;  1ED9 A;  3BDF A;  1E33 P;  5GRR A;  2W8S A;  1ZEB A;  5EGE A;  3NKP A;  2W5V A;  2W5W A;  4UPH A;  1SHQ A;  1KHL A;  1E3C P;  1E1Z P;  1KHJ A;  1AJD A;  1KHK A;  4UOR A;  1P49 A;  3KD8 A;  2QZU A;  3M8Y A;  4NWJ A;  4CXK A;  4ZG9 A;  4QAX A;  2RH6 A;  2XR9 A;  4LRD A;  3T01 A;  1URB A;  1ALK A;  1KHN A;  1Y6V A;  1EJJ A;  3Q3Q A;  4N7T A;  5DLV A;  1E2S P;  3WBH A;  4KJD A;  1ANI A;  3NKQ A;  3MK1 A;  3TX0 A;  2W5S A;  1EI6 A;  2GLQ A;  4ZG6 A;  1KH5 A;  3NVL A;  1N2L A;  2IUC B;  3LXQ A;  4KJG A;  2D1G A;  2W5X A;  2ZKT A;  1ANJ A;  1HDH A;  5L0K A;  3SZY A;  2VQR A;  4CXS A;  1AJC A;  1ELX A;  3TG0 A;  1EW9 A;  1K7H A;  4FDJ A;  2GSU A;  2GA3 A;  1ELY A;  3NKO A;  3DYC A;  3IGY B;  4NWX A;  2XRG A;  3T00 A;  2G9Y A;  4LR8 A;  5GOV A;  5LRM A;  1O98 A;  4KAY A;  3M8W A;  4UOO A;  5LQQ A;  2ANH A;  4FDI A;  2GSN A;  1ED8 A;  3M8Z A;  3UN3 A;  3UO0 A;  5AJ9 A;  3NKN A;  5C66 A;  3WAW A;  2X98 A;  3BDG B;  5KXA A;  1KH9 A;  2W5Q A;  4B56 A;  4GTW A;  4CYS A;  4GTY A;  3UNY A;  1KH7 A;  4ZGA A;  4LQY A;  1ELZ A;  3E2D A;  3M7V A;  2GSO A;  5L0E A;  4LRE A;  4KM4 A;  1AUK A;  1N2K A;  3UN5 A;  4KAV A;  4LR9 A;  2IFY A;  3WAV A;  1ALJ A;  5DLW A;  1AJB A;  1ZED A;  1FSU A;  1AJA A;  3UN2 A;  2W5T A;  5L0B A;  3TWZ A;  1KH4 A;  4LRC A;  4CYR A;  4LR7 A;  3BDH A;  3OT9 A;  4YR1 A;  1EQJ A;  1Y7A A;  5DLT A;  4ZG7 A;  3DPC A;  2W5R A;  5IJS A;  5HRT A;  3MK0 A;  1ALI A;  3IGZ B;  3B5Q A;  3WAX A;  3IDD A;  4MHX A;  3NKR A;  3A52 A;  1HJK A;  1O99 A;  4GTZ A;  1SHN A;  2W8D A;  5LRN A;  4GTX A;  4UPK A;  5TJ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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