1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Total Genus 167
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
167
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 167
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
4CYSA 4LQYA 1E1ZP 4GTYA 1AJCA 1N2KA 4LRBA 2IUCA 5EGEA 3WAVA 3LXQA 3M8YA 1ZEBA 1KHJA 1EW8A 1ELYA 1SHQA 3NVLA 1KHLA 2W5WA 3NKOA 3M8ZA 3DYCA 1ALHA 4KJGA 2XRGA 5DLWA 3BDHA 1N2LA 3A52A 3MK0A 1ANIA 3Q3QA 3T00A 3OT9A 1ELXA 4CXUA 3CMRA 5LQQA 2D1GA 3BDGA 2W5XA 3MK2A 3BDFA 2W5SA 2ZKTA 2W5TA 2G9YA 4LR2A 4LRCA 2IUCB 2RH6A 2W8DA 3UN3A 1ALKA 4NWJA 2W5VA 4QAXA 5L0BA 5L0KA 4LREA 4UOPA 4UPIA 4UOOA 5IJSA 1KHNA 5LRMA 1EI6A 1EW9A 3WBHA 3NKNA 3UNYA 4ZGAA 5DLTA 3MK1A 1P49A 4UORA 1ZEDA 3WAYA 4LRAA 3SZZA 1EW2A 2ANHA 3UN5A 1E3CP 1Y6VA 4CXKA 2XR9A 3IGYB 4KAVA 4KAYA 1EQJA 3T01A 1URBA 3UO0A 4ZG9A 1SHNA 3NKMA 3NKRA 3NKQA 5GRRA 4MIVA 4UPHA 1URAA 3E2DA 4FDJA 4LR7A 2GSNA 5LIAA 5INHA 4LR9A 3NKPA 3WAWA 1ALJA 2GSUA 3B5QA 1KH9A 2W5RA 4LRFA 2GSOA 3TX0A 2W8SA 1HJKA 4B56A 3KD8A 4MY4A 2QZUA 1KHKA 1ANJA 3WAXA 3TG0A 4LR8A 1AUKA 3UN2A 5TJ3A 3BDGB 1O99A 3TWZA 2GA3A 5KXAA 1B8JA 1E2SP 3DPCA 4ZG7A 1AJAA 2GLQA 3M7VA 5EGHA 2IFYA 4UPLA 4ZG6A 2X98A 1Y7AA 1K7HA 1O98A 5C66A 3SZYA 4CYRA 1AJBA 4LRDA 1ZEFA 5GOVA 1HQAA 3T02A 1FSUA 1KH7A 5AJ9A 3IGZB 4N7TA 5IJQA 4KM4A 5DLVA 2VQRA 5HRTA 4KJDA 1KH4A 1ELZA 1E33P 4NWXA 4MHXA 4CXSA 1ALIA 3M8WA 4GTWA 3IDDA 1ED8A 4GTXA 1KH5A 4YR1A 1AJDA 1ED9A 4FDIA 4TN0A 1EJJA 5K4PA 3ED4A 2W5QA 1HDHA 4UPKA 4GTZA 5L0EA 5LRNA
chains in the Genus database with same CATH superfamily
4CYSA 4LQYA 1E1ZP 4GTYA 1AJCA 1N2KA 4LRBA 2IUCA 5EGEA 3WAVA 3LXQA 3M8YA 1ZEBA 1KHJA 1EW8A 1ELYA 1SHQA 3NVLA 1KHLA 2W5WA 3NKOA 3M8ZA 3DYCA 1ALHA 4KJGA 2XRGA 5DLWA 3BDHA 1N2LA 3A52A 3MK0A 1ANIA 3Q3QA 3T00A 3OT9A 1ELXA 4CXUA 3CMRA 5LQQA 2D1GA 3BDGA 2W5XA 3MK2A 3BDFA 2W5SA 2ZKTA 2W5TA 2G9YA 4LR2A 4LRCA 2IUCB 2RH6A 2W8DA 3UN3A 1ALKA 4NWJA 2W5VA 4QAXA 5L0BA 5L0KA 4LREA 4UOPA 4UPIA 4UOOA 5IJSA 1KHNA 5LRMA 1EI6A 1EW9A 3WBHA 3NKNA 3UNYA 4ZGAA 5DLTA 3MK1A 1P49A 4UORA 1ZEDA 3WAYA 4LRAA 3SZZA 1EW2A 2ANHA 3UN5A 1E3CP 1Y6VA 4CXKA 2XR9A 3IGYB 4KAVA 4KAYA 1EQJA 3T01A 1URBA 3UO0A 4ZG9A 1SHNA 3NKMA 3NKRA 3NKQA 5GRRA 4MIVA 4UPHA 1URAA 3E2DA 4FDJA 4LR7A 2GSNA 5LIAA 5INHA 4LR9A 3NKPA 3WAWA 1ALJA 2GSUA 3B5QA 1KH9A 2W5RA 4LRFA 2GSOA 3TX0A 2W8SA 1HJKA 4B56A 3KD8A 4MY4A 2QZUA 1KHKA 1ANJA 3WAXA 3TG0A 4LR8A 1AUKA 3UN2A 5TJ3A 3BDGB 1O99A 3TWZA 2GA3A 5KXAA 1B8JA 1E2SP 3DPCA 4ZG7A 1AJAA 2GLQA 3M7VA 5EGHA 2IFYA 4UPLA 4ZG6A 2X98A 1Y7AA 1K7HA 1O98A 5C66A 3SZYA 4CYRA 1AJBA 4LRDA 1ZEFA 5GOVA 1HQAA 3T02A 1FSUA 1KH7A 5AJ9A 3IGZB 4N7TA 5IJQA 4KM4A 5DLVA 2VQRA 5HRTA 4KJDA 1KH4A 1ELZA 1E33P 4NWXA 4MHXA 4CXSA 1ALIA 3M8WA 4GTWA 3IDDA 1ED8A 4GTXA 1KH5A 4YR1A 1AJDA 1ED9A 4FDIA 4TN0A 1EJJA 5K4PA 3ED4A 2W5QA 1HDHA 4UPKA 4GTZA 5L0EA 5LRNA
chains in the Genus database with same CATH topology
4CYSA 4LQYA 1E1ZP 4GTYA 1AJCA 1N2KA 4LRBA 2IUCA 5EGEA 3WAVA 3LXQA 3M8YA 1ZEBA 1KHJA 1EW8A 1ELYA 1SHQA 3NVLA 1KHLA 2W5WA 3NKOA 3M8ZA 3DYCA 1ALHA 4KJGA 2XRGA 5DLWA 3BDHA 1N2LA 3A52A 3MK0A 1ANIA 3Q3QA 3T00A 3OT9A 1ELXA 4CXUA 3CMRA 5LQQA 2D1GA 3BDGA 2W5XA 3MK2A 3BDFA 2W5SA 2ZKTA 2W5TA 2G9YA 4LR2A 4LRCA 2IUCB 2RH6A 2W8DA 3UN3A 1ALKA 4NWJA 2W5VA 4QAXA 5L0BA 5L0KA 4LREA 4UOPA 4UPIA 4UOOA 5IJSA 1KHNA 5LRMA 1EI6A 1EW9A 3WBHA 3NKNA 3UNYA 4ZGAA 5DLTA 3MK1A 1P49A 4UORA 1ZEDA 3WAYA 4LRAA 3SZZA 1EW2A 2ANHA 3UN5A 1E3CP 1Y6VA 4CXKA 2XR9A 3IGYB 4KAVA 4KAYA 1EQJA 3T01A 1URBA 3UO0A 4ZG9A 1SHNA 3NKMA 3NKRA 3NKQA 5GRRA 4MIVA 4UPHA 1URAA 3E2DA 4FDJA 4LR7A 2GSNA 5LIAA 5INHA 4LR9A 3NKPA 3WAWA 1ALJA 2GSUA 3B5QA 1KH9A 2W5RA 4LRFA 2GSOA 3TX0A 2W8SA 1HJKA 4B56A 3KD8A 4MY4A 2QZUA 1KHKA 1ANJA 3WAXA 3TG0A 4LR8A 1AUKA 3UN2A 5TJ3A 3BDGB 1O99A 3TWZA 2GA3A 5KXAA 1B8JA 1E2SP 3DPCA 4ZG7A 1AJAA 2GLQA 3M7VA 5EGHA 2IFYA 4UPLA 4ZG6A 2X98A 1Y7AA 1K7HA 1O98A 5C66A 3SZYA 4CYRA 1AJBA 4LRDA 1ZEFA 5GOVA 1HQAA 3T02A 1FSUA 1KH7A 5AJ9A 3IGZB 4N7TA 5IJQA 4KM4A 5DLVA 2VQRA 5HRTA 4KJDA 1KH4A 1ELZA 1E33P 4NWXA 4MHXA 4CXSA 1ALIA 3M8WA 4GTWA 3IDDA 1ED8A 4GTXA 1KH5A 4YR1A 1AJDA 1ED9A 4FDIA 4TN0A 1EJJA 5K4PA 3ED4A 2W5QA 1HDHA 4UPKA 4GTZA 5L0EA 5LRNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CYS A;  4LQY A;  1E1Z P;  4GTY A;  1AJC A;  1N2K A;  4LRB A;  2IUC A;  5EGE A;  3WAV A;  3LXQ A;  3M8Y A;  1ZEB A;  1KHJ A;  1EW8 A;  1ELY A;  1SHQ A;  3NVL A;  1KHL A;  2W5W A;  3NKO A;  3M8Z A;  3DYC A;  1ALH A;  4KJG A;  2XRG A;  5DLW A;  3BDH A;  1N2L A;  3A52 A;  3MK0 A;  1ANI A;  3Q3Q A;  3T00 A;  3OT9 A;  1ELX A;  4CXU A;  3CMR A;  5LQQ A;  2D1G A;  3BDG A;  2W5X A;  3MK2 A;  3BDF A;  2W5S A;  2ZKT A;  2W5T A;  2G9Y A;  4LR2 A;  4LRC A;  2IUC B;  2RH6 A;  2W8D A;  3UN3 A;  1ALK A;  4NWJ A;  2W5V A;  4QAX A;  5L0B A;  5L0K A;  4LRE A;  4UOP A;  4UPI A;  4UOO A;  5IJS A;  1KHN A;  5LRM A;  1EI6 A;  1EW9 A;  3WBH A;  3NKN A;  3UNY A;  4ZGA A;  5DLT A;  3MK1 A;  1P49 A;  4UOR A;  1ZED A;  3WAY A;  4LRA A;  3SZZ A;  1EW2 A;  2ANH A;  3UN5 A;  1E3C P;  1Y6V A;  4CXK A;  2XR9 A;  3IGY B;  4KAV A;  4KAY A;  1EQJ A;  3T01 A;  1URB A;  3UO0 A;  4ZG9 A;  1SHN A;  3NKM A;  3NKR A;  3NKQ A;  5GRR A;  4MIV A;  4UPH A;  1URA A;  3E2D A;  4FDJ A;  4LR7 A;  2GSN A;  5LIA A;  5INH A;  4LR9 A;  3NKP A;  3WAW A;  1ALJ A;  2GSU A;  3B5Q A;  1KH9 A;  2W5R A;  4LRF A;  2GSO A;  3TX0 A;  2W8S A;  1HJK A;  4B56 A;  3KD8 A;  4MY4 A;  2QZU A;  1KHK A;  1ANJ A;  3WAX A;  3TG0 A;  4LR8 A;  1AUK A;  3UN2 A;  5TJ3 A;  3BDG B;  1O99 A;  3TWZ A;  2GA3 A;  5KXA A;  1B8J A;  1E2S P;  3DPC A;  4ZG7 A;  1AJA A;  2GLQ A;  3M7V A;  5EGH A;  2IFY A;  4UPL A;  4ZG6 A;  2X98 A;  1Y7A A;  1K7H A;  1O98 A;  5C66 A;  3SZY A;  4CYR A;  1AJB A;  4LRD A;  1ZEF A;  5GOV A;  1HQA A;  3T02 A;  1FSU A;  1KH7 A;  5AJ9 A;  3IGZ B;  4N7T A;  5IJQ A;  4KM4 A;  5DLV A;  2VQR A;  5HRT A;  4KJD A;  1KH4 A;  1ELZ A;  1E33 P;  4NWX A;  4MHX A;  4CXS A;  1ALI A;  3M8W A;  4GTW A;  3IDD A;  1ED8 A;  4GTX A;  1KH5 A;  4YR1 A;  1AJD A;  1ED9 A;  4FDI A;  4TN0 A;  1EJJ A;  5K4P A;  3ED4 A;  2W5Q A;  1HDH A;  4UPK A;  4GTZ A;  5L0E A;  5LRN A; 
#chains in the Genus database with same CATH topology
 4CYS A;  4LQY A;  1E1Z P;  4GTY A;  1AJC A;  1N2K A;  4LRB A;  2IUC A;  5EGE A;  3WAV A;  3LXQ A;  3M8Y A;  1ZEB A;  1KHJ A;  1EW8 A;  1ELY A;  1SHQ A;  3NVL A;  1KHL A;  2W5W A;  3NKO A;  3M8Z A;  3DYC A;  1ALH A;  4KJG A;  2XRG A;  5DLW A;  3BDH A;  1N2L A;  3A52 A;  3MK0 A;  1ANI A;  3Q3Q A;  3T00 A;  3OT9 A;  1ELX A;  4CXU A;  3CMR A;  5LQQ A;  2D1G A;  3BDG A;  2W5X A;  3MK2 A;  3BDF A;  2W5S A;  2ZKT A;  2W5T A;  2G9Y A;  4LR2 A;  4LRC A;  2IUC B;  2RH6 A;  2W8D A;  3UN3 A;  1ALK A;  4NWJ A;  2W5V A;  4QAX A;  5L0B A;  5L0K A;  4LRE A;  4UOP A;  4UPI A;  4UOO A;  5IJS A;  1KHN A;  5LRM A;  1EI6 A;  1EW9 A;  3WBH A;  3NKN A;  3UNY A;  4ZGA A;  5DLT A;  3MK1 A;  1P49 A;  4UOR A;  1ZED A;  3WAY A;  4LRA A;  3SZZ A;  1EW2 A;  2ANH A;  3UN5 A;  1E3C P;  1Y6V A;  4CXK A;  2XR9 A;  3IGY B;  4KAV A;  4KAY A;  1EQJ A;  3T01 A;  1URB A;  3UO0 A;  4ZG9 A;  1SHN A;  3NKM A;  3NKR A;  3NKQ A;  5GRR A;  4MIV A;  4UPH A;  1URA A;  3E2D A;  4FDJ A;  4LR7 A;  2GSN A;  5LIA A;  5INH A;  4LR9 A;  3NKP A;  3WAW A;  1ALJ A;  2GSU A;  3B5Q A;  1KH9 A;  2W5R A;  4LRF A;  2GSO A;  3TX0 A;  2W8S A;  1HJK A;  4B56 A;  3KD8 A;  4MY4 A;  2QZU A;  1KHK A;  1ANJ A;  3WAX A;  3TG0 A;  4LR8 A;  1AUK A;  3UN2 A;  5TJ3 A;  3BDG B;  1O99 A;  3TWZ A;  2GA3 A;  5KXA A;  1B8J A;  1E2S P;  3DPC A;  4ZG7 A;  1AJA A;  2GLQ A;  3M7V A;  5EGH A;  2IFY A;  4UPL A;  4ZG6 A;  2X98 A;  1Y7A A;  1K7H A;  1O98 A;  5C66 A;  3SZY A;  4CYR A;  1AJB A;  4LRD A;  1ZEF A;  5GOV A;  1HQA A;  3T02 A;  1FSU A;  1KH7 A;  5AJ9 A;  3IGZ B;  4N7T A;  5IJQ A;  4KM4 A;  5DLV A;  2VQR A;  5HRT A;  4KJD A;  1KH4 A;  1ELZ A;  1E33 P;  4NWX A;  4MHX A;  4CXS A;  1ALI A;  3M8W A;  4GTW A;  3IDD A;  1ED8 A;  4GTX A;  1KH5 A;  4YR1 A;  1AJD A;  1ED9 A;  4FDI A;  4TN0 A;  1EJJ A;  5K4P A;  3ED4 A;  2W5Q A;  1HDH A;  4UPK A;  4GTZ A;  5L0E A;  5LRN A; 
#chains in the Genus database with same CATH homology
 4CYS A;  4LQY A;  1E1Z P;  4GTY A;  1AJC A;  1N2K A;  4LRB A;  2IUC A;  5EGE A;  3WAV A;  3LXQ A;  3M8Y A;  1ZEB A;  1KHJ A;  1EW8 A;  1ELY A;  1SHQ A;  3NVL A;  1KHL A;  2W5W A;  3NKO A;  3M8Z A;  3DYC A;  1ALH A;  4KJG A;  2XRG A;  5DLW A;  3BDH A;  1N2L A;  3A52 A;  3MK0 A;  1ANI A;  3Q3Q A;  3T00 A;  3OT9 A;  1ELX A;  4CXU A;  3CMR A;  5LQQ A;  2D1G A;  3BDG A;  2W5X A;  3MK2 A;  3BDF A;  2W5S A;  2ZKT A;  2W5T A;  2G9Y A;  4LR2 A;  4LRC A;  2IUC B;  2RH6 A;  2W8D A;  3UN3 A;  1ALK A;  4NWJ A;  2W5V A;  4QAX A;  5L0B A;  5L0K A;  4LRE A;  4UOP A;  4UPI A;  4UOO A;  5IJS A;  1KHN A;  5LRM A;  1EI6 A;  1EW9 A;  3WBH A;  3NKN A;  3UNY A;  4ZGA A;  5DLT A;  3MK1 A;  1P49 A;  4UOR A;  1ZED A;  3WAY A;  4LRA A;  3SZZ A;  1EW2 A;  2ANH A;  3UN5 A;  1E3C P;  1Y6V A;  4CXK A;  2XR9 A;  3IGY B;  4KAV A;  4KAY A;  1EQJ A;  3T01 A;  1URB A;  3UO0 A;  4ZG9 A;  1SHN A;  3NKM A;  3NKR A;  3NKQ A;  5GRR A;  4MIV A;  4UPH A;  1URA A;  3E2D A;  4FDJ A;  4LR7 A;  2GSN A;  5LIA A;  5INH A;  4LR9 A;  3NKP A;  3WAW A;  1ALJ A;  2GSU A;  3B5Q A;  1KH9 A;  2W5R A;  4LRF A;  2GSO A;  3TX0 A;  2W8S A;  1HJK A;  4B56 A;  3KD8 A;  4MY4 A;  2QZU A;  1KHK A;  1ANJ A;  3WAX A;  3TG0 A;  4LR8 A;  1AUK A;  3UN2 A;  5TJ3 A;  3BDG B;  1O99 A;  3TWZ A;  2GA3 A;  5KXA A;  1B8J A;  1E2S P;  3DPC A;  4ZG7 A;  1AJA A;  2GLQ A;  3M7V A;  5EGH A;  2IFY A;  4UPL A;  4ZG6 A;  2X98 A;  1Y7A A;  1K7H A;  1O98 A;  5C66 A;  3SZY A;  4CYR A;  1AJB A;  4LRD A;  1ZEF A;  5GOV A;  1HQA A;  3T02 A;  1FSU A;  1KH7 A;  5AJ9 A;  3IGZ B;  4N7T A;  5IJQ A;  4KM4 A;  5DLV A;  2VQR A;  5HRT A;  4KJD A;  1KH4 A;  1ELZ A;  1E33 P;  4NWX A;  4MHX A;  4CXS A;  1ALI A;  3M8W A;  4GTW A;  3IDD A;  1ED8 A;  4GTX A;  1KH5 A;  4YR1 A;  1AJD A;  1ED9 A;  4FDI A;  4TN0 A;  1EJJ A;  5K4P A;  3ED4 A;  2W5Q A;  1HDH A;  4UPK A;  4GTZ A;  5L0E A;  5LRN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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