2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
molecule tags Hydrolase
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
2W5WA 5IJSA 4UPIA 2GSNA 4UOPA 3WAYA 3IGZB 5K4PA 4LRBA 2W5RA 1Y7AA 2W5VA 4LRDA 1AJBA 4GTZA 3SZYA 1FSUA 3M8YA 4LREA 1KHJA 3BDFA 2VQRA 2IUCB 1ZEDA 4UPLA 1E33P 3IDDA 4GTYA 4ZG6A 1EW8A 2X98A 3T01A 5LQQA 5DLVA 3WAVA 1ED9A 5AJ9A 4UORA 3NKOA 3WBHA 1Y6VA 3MK1A 2W8SA 5LRMA 3MK2A 2W8DA 1KH7A 1O98A 3NVLA 3UN5A 1EQJA 5INHA 1N2LA 3DYCA 4KJGA 4LR9A 2QZUA 3KD8A 4LRAA 3UN3A 4GTWA 3WAWA 1ELYA 1URAA 4MHXA 4MY4A 4ZGAA 1SHNA 3TX0A 4CXSA 1B8JA 3DPCA 2ANHA 1KH4A 1HQAA 1KH9A 3M8ZA 1KHLA 1ANIA 4LR8A 1EW9A 1ED8A 1URBA 1K7HA 1ALKA 3BDGA 1KH5A 1ELZA 2W5XA 4LQYA 2D1GA 2GLQA 2GSUA 3NKMA 1AJDA 3NKQA 1AUKA 3MK0A 1O99A 2W5SA 4UOOA 2W5TA 2XR9A 2RH6A 5DLTA 1AJAA 2GA3A 3TWZA 4N7TA 4TN0A 3OT9A 4CYRA 5EGEA 4LR2A 3T02A 1AJCA 1ELXA 3NKNA 1EI6A 1N2KA 5LIAA 3CMRA 2GSOA 3M7VA 5L0KA 1ALJA 1EJJA 3SZZA 3UN2A 1ZEFA 1HJKA 5GRRA 5IJQA 5KXAA 2W5QA 4KM4A 3NKPA 4CXUA 5C66A 1E2SP 1ZEBA 3NKRA 4LRFA 1E1ZP 1KHNA 1ALHA 3TG0A 4ZG9A 4LR7A 5EGHA 4GTXA 4UPHA 3LXQA 4CXKA 5L0BA 1ALIA 1P49A 5L0EA 4NWXA 3T00A 2XRGA 4ZG7A 3ED4A 4FDJA 3UO0A 3E2DA 4FDIA 5LRNA 4LRCA 2G9YA 3M8WA 4KJDA 3WAXA 5GOVA 3BDHA 1KHKA 3A52A 5TJ3A 4NWJA 3Q3QA 1EW2A 4QAXA 1HDHA 2IUCA 3BDGB 5DLWA 1ANJA 4B56A 5HRTA 4MIVA 3UNYA 4YR1A 3IGYB 4UPKA 1E3CP 2IFYA 3B5QA 1SHQA 4KAYA 4KAVA 2ZKTA 4CYSA
chains in the Genus database with same CATH superfamily
2W5WA 5IJSA 4UPIA 2GSNA 4UOPA 3WAYA 3IGZB 5K4PA 4LRBA 2W5RA 1Y7AA 2W5VA 4LRDA 1AJBA 4GTZA 3SZYA 1FSUA 3M8YA 4LREA 1KHJA 3BDFA 2VQRA 2IUCB 1ZEDA 4UPLA 1E33P 3IDDA 4GTYA 4ZG6A 1EW8A 2X98A 3T01A 5LQQA 5DLVA 3WAVA 1ED9A 5AJ9A 4UORA 3NKOA 3WBHA 1Y6VA 3MK1A 2W8SA 5LRMA 3MK2A 2W8DA 1KH7A 1O98A 3NVLA 3UN5A 1EQJA 5INHA 1N2LA 3DYCA 4KJGA 4LR9A 2QZUA 3KD8A 4LRAA 3UN3A 4GTWA 3WAWA 1ELYA 1URAA 4MHXA 4MY4A 4ZGAA 1SHNA 3TX0A 4CXSA 1B8JA 3DPCA 2ANHA 1KH4A 1HQAA 1KH9A 3M8ZA 1KHLA 1ANIA 4LR8A 1EW9A 1ED8A 1URBA 1K7HA 1ALKA 3BDGA 1KH5A 1ELZA 2W5XA 4LQYA 2D1GA 2GLQA 2GSUA 3NKMA 1AJDA 3NKQA 1AUKA 3MK0A 1O99A 2W5SA 4UOOA 2W5TA 2XR9A 2RH6A 5DLTA 1AJAA 2GA3A 3TWZA 4N7TA 4TN0A 3OT9A 4CYRA 5EGEA 4LR2A 3T02A 1AJCA 1ELXA 3NKNA 1EI6A 1N2KA 5LIAA 3CMRA 2GSOA 3M7VA 5L0KA 1ALJA 1EJJA 3SZZA 3UN2A 1ZEFA 1HJKA 5GRRA 5IJQA 5KXAA 2W5QA 4KM4A 3NKPA 4CXUA 5C66A 1E2SP 1ZEBA 3NKRA 4LRFA 1E1ZP 1KHNA 1ALHA 3TG0A 4ZG9A 4LR7A 5EGHA 4GTXA 4UPHA 3LXQA 4CXKA 5L0BA 1ALIA 1P49A 5L0EA 4NWXA 3T00A 2XRGA 4ZG7A 3ED4A 4FDJA 3UO0A 3E2DA 4FDIA 5LRNA 4LRCA 2G9YA 3M8WA 4KJDA 3WAXA 5GOVA 3BDHA 1KHKA 3A52A 5TJ3A 4NWJA 3Q3QA 1EW2A 4QAXA 1HDHA 2IUCA 3BDGB 5DLWA 1ANJA 4B56A 5HRTA 4MIVA 3UNYA 4YR1A 3IGYB 4UPKA 1E3CP 2IFYA 3B5QA 1SHQA 4KAYA 4KAVA 2ZKTA 4CYSA
chains in the Genus database with same CATH topology
2W5WA 5IJSA 4UPIA 2GSNA 4UOPA 3WAYA 3IGZB 5K4PA 4LRBA 2W5RA 1Y7AA 2W5VA 4LRDA 1AJBA 4GTZA 3SZYA 1FSUA 3M8YA 4LREA 1KHJA 3BDFA 2VQRA 2IUCB 1ZEDA 4UPLA 1E33P 3IDDA 4GTYA 4ZG6A 1EW8A 2X98A 3T01A 5LQQA 5DLVA 3WAVA 1ED9A 5AJ9A 4UORA 3NKOA 3WBHA 1Y6VA 3MK1A 2W8SA 5LRMA 3MK2A 2W8DA 1KH7A 1O98A 3NVLA 3UN5A 1EQJA 5INHA 1N2LA 3DYCA 4KJGA 4LR9A 2QZUA 3KD8A 4LRAA 3UN3A 4GTWA 3WAWA 1ELYA 1URAA 4MHXA 4MY4A 4ZGAA 1SHNA 3TX0A 4CXSA 1B8JA 3DPCA 2ANHA 1KH4A 1HQAA 1KH9A 3M8ZA 1KHLA 1ANIA 4LR8A 1EW9A 1ED8A 1URBA 1K7HA 1ALKA 3BDGA 1KH5A 1ELZA 2W5XA 4LQYA 2D1GA 2GLQA 2GSUA 3NKMA 1AJDA 3NKQA 1AUKA 3MK0A 1O99A 2W5SA 4UOOA 2W5TA 2XR9A 2RH6A 5DLTA 1AJAA 2GA3A 3TWZA 4N7TA 4TN0A 3OT9A 4CYRA 5EGEA 4LR2A 3T02A 1AJCA 1ELXA 3NKNA 1EI6A 1N2KA 5LIAA 3CMRA 2GSOA 3M7VA 5L0KA 1ALJA 1EJJA 3SZZA 3UN2A 1ZEFA 1HJKA 5GRRA 5IJQA 5KXAA 2W5QA 4KM4A 3NKPA 4CXUA 5C66A 1E2SP 1ZEBA 3NKRA 4LRFA 1E1ZP 1KHNA 1ALHA 3TG0A 4ZG9A 4LR7A 5EGHA 4GTXA 4UPHA 3LXQA 4CXKA 5L0BA 1ALIA 1P49A 5L0EA 4NWXA 3T00A 2XRGA 4ZG7A 3ED4A 4FDJA 3UO0A 3E2DA 4FDIA 5LRNA 4LRCA 2G9YA 3M8WA 4KJDA 3WAXA 5GOVA 3BDHA 1KHKA 3A52A 5TJ3A 4NWJA 3Q3QA 1EW2A 4QAXA 1HDHA 2IUCA 3BDGB 5DLWA 1ANJA 4B56A 5HRTA 4MIVA 3UNYA 4YR1A 3IGYB 4UPKA 1E3CP 2IFYA 3B5QA 1SHQA 4KAYA 4KAVA 2ZKTA 4CYSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5W A;  5IJS A;  4UPI A;  2GSN A;  4UOP A;  3WAY A;  3IGZ B;  5K4P A;  4LRB A;  2W5R A;  1Y7A A;  2W5V A;  4LRD A;  1AJB A;  4GTZ A;  3SZY A;  1FSU A;  3M8Y A;  4LRE A;  1KHJ A;  3BDF A;  2VQR A;  2IUC B;  1ZED A;  4UPL A;  1E33 P;  3IDD A;  4GTY A;  4ZG6 A;  1EW8 A;  2X98 A;  3T01 A;  5LQQ A;  5DLV A;  3WAV A;  1ED9 A;  5AJ9 A;  4UOR A;  3NKO A;  3WBH A;  1Y6V A;  3MK1 A;  2W8S A;  5LRM A;  3MK2 A;  2W8D A;  1KH7 A;  1O98 A;  3NVL A;  3UN5 A;  1EQJ A;  5INH A;  1N2L A;  3DYC A;  4KJG A;  4LR9 A;  2QZU A;  3KD8 A;  4LRA A;  3UN3 A;  4GTW A;  3WAW A;  1ELY A;  1URA A;  4MHX A;  4MY4 A;  4ZGA A;  1SHN A;  3TX0 A;  4CXS A;  1B8J A;  3DPC A;  2ANH A;  1KH4 A;  1HQA A;  1KH9 A;  3M8Z A;  1KHL A;  1ANI A;  4LR8 A;  1EW9 A;  1ED8 A;  1URB A;  1K7H A;  1ALK A;  3BDG A;  1KH5 A;  1ELZ A;  2W5X A;  4LQY A;  2D1G A;  2GLQ A;  2GSU A;  3NKM A;  1AJD A;  3NKQ A;  1AUK A;  3MK0 A;  1O99 A;  2W5S A;  4UOO A;  2W5T A;  2XR9 A;  2RH6 A;  5DLT A;  1AJA A;  2GA3 A;  3TWZ A;  4N7T A;  4TN0 A;  3OT9 A;  4CYR A;  5EGE A;  4LR2 A;  3T02 A;  1AJC A;  1ELX A;  3NKN A;  1EI6 A;  1N2K A;  5LIA A;  3CMR A;  2GSO A;  3M7V A;  5L0K A;  1ALJ A;  1EJJ A;  3SZZ A;  3UN2 A;  1ZEF A;  1HJK A;  5GRR A;  5IJQ A;  5KXA A;  2W5Q A;  4KM4 A;  3NKP A;  4CXU A;  5C66 A;  1E2S P;  1ZEB A;  3NKR A;  4LRF A;  1E1Z P;  1KHN A;  1ALH A;  3TG0 A;  4ZG9 A;  4LR7 A;  5EGH A;  4GTX A;  4UPH A;  3LXQ A;  4CXK A;  5L0B A;  1ALI A;  1P49 A;  5L0E A;  4NWX A;  3T00 A;  2XRG A;  4ZG7 A;  3ED4 A;  4FDJ A;  3UO0 A;  3E2D A;  4FDI A;  5LRN A;  4LRC A;  2G9Y A;  3M8W A;  4KJD A;  3WAX A;  5GOV A;  3BDH A;  1KHK A;  3A52 A;  5TJ3 A;  4NWJ A;  3Q3Q A;  1EW2 A;  4QAX A;  1HDH A;  2IUC A;  3BDG B;  5DLW A;  1ANJ A;  4B56 A;  5HRT A;  4MIV A;  3UNY A;  4YR1 A;  3IGY B;  4UPK A;  1E3C P;  2IFY A;  3B5Q A;  1SHQ A;  4KAY A;  4KAV A;  2ZKT A;  4CYS A; 
#chains in the Genus database with same CATH topology
 2W5W A;  5IJS A;  4UPI A;  2GSN A;  4UOP A;  3WAY A;  3IGZ B;  5K4P A;  4LRB A;  2W5R A;  1Y7A A;  2W5V A;  4LRD A;  1AJB A;  4GTZ A;  3SZY A;  1FSU A;  3M8Y A;  4LRE A;  1KHJ A;  3BDF A;  2VQR A;  2IUC B;  1ZED A;  4UPL A;  1E33 P;  3IDD A;  4GTY A;  4ZG6 A;  1EW8 A;  2X98 A;  3T01 A;  5LQQ A;  5DLV A;  3WAV A;  1ED9 A;  5AJ9 A;  4UOR A;  3NKO A;  3WBH A;  1Y6V A;  3MK1 A;  2W8S A;  5LRM A;  3MK2 A;  2W8D A;  1KH7 A;  1O98 A;  3NVL A;  3UN5 A;  1EQJ A;  5INH A;  1N2L A;  3DYC A;  4KJG A;  4LR9 A;  2QZU A;  3KD8 A;  4LRA A;  3UN3 A;  4GTW A;  3WAW A;  1ELY A;  1URA A;  4MHX A;  4MY4 A;  4ZGA A;  1SHN A;  3TX0 A;  4CXS A;  1B8J A;  3DPC A;  2ANH A;  1KH4 A;  1HQA A;  1KH9 A;  3M8Z A;  1KHL A;  1ANI A;  4LR8 A;  1EW9 A;  1ED8 A;  1URB A;  1K7H A;  1ALK A;  3BDG A;  1KH5 A;  1ELZ A;  2W5X A;  4LQY A;  2D1G A;  2GLQ A;  2GSU A;  3NKM A;  1AJD A;  3NKQ A;  1AUK A;  3MK0 A;  1O99 A;  2W5S A;  4UOO A;  2W5T A;  2XR9 A;  2RH6 A;  5DLT A;  1AJA A;  2GA3 A;  3TWZ A;  4N7T A;  4TN0 A;  3OT9 A;  4CYR A;  5EGE A;  4LR2 A;  3T02 A;  1AJC A;  1ELX A;  3NKN A;  1EI6 A;  1N2K A;  5LIA A;  3CMR A;  2GSO A;  3M7V A;  5L0K A;  1ALJ A;  1EJJ A;  3SZZ A;  3UN2 A;  1ZEF A;  1HJK A;  5GRR A;  5IJQ A;  5KXA A;  2W5Q A;  4KM4 A;  3NKP A;  4CXU A;  5C66 A;  1E2S P;  1ZEB A;  3NKR A;  4LRF A;  1E1Z P;  1KHN A;  1ALH A;  3TG0 A;  4ZG9 A;  4LR7 A;  5EGH A;  4GTX A;  4UPH A;  3LXQ A;  4CXK A;  5L0B A;  1ALI A;  1P49 A;  5L0E A;  4NWX A;  3T00 A;  2XRG A;  4ZG7 A;  3ED4 A;  4FDJ A;  3UO0 A;  3E2D A;  4FDI A;  5LRN A;  4LRC A;  2G9Y A;  3M8W A;  4KJD A;  3WAX A;  5GOV A;  3BDH A;  1KHK A;  3A52 A;  5TJ3 A;  4NWJ A;  3Q3Q A;  1EW2 A;  4QAX A;  1HDH A;  2IUC A;  3BDG B;  5DLW A;  1ANJ A;  4B56 A;  5HRT A;  4MIV A;  3UNY A;  4YR1 A;  3IGY B;  4UPK A;  1E3C P;  2IFY A;  3B5Q A;  1SHQ A;  4KAY A;  4KAV A;  2ZKT A;  4CYS A; 
#chains in the Genus database with same CATH homology
 2W5W A;  5IJS A;  4UPI A;  2GSN A;  4UOP A;  3WAY A;  3IGZ B;  5K4P A;  4LRB A;  2W5R A;  1Y7A A;  2W5V A;  4LRD A;  1AJB A;  4GTZ A;  3SZY A;  1FSU A;  3M8Y A;  4LRE A;  1KHJ A;  3BDF A;  2VQR A;  2IUC B;  1ZED A;  4UPL A;  1E33 P;  3IDD A;  4GTY A;  4ZG6 A;  1EW8 A;  2X98 A;  3T01 A;  5LQQ A;  5DLV A;  3WAV A;  1ED9 A;  5AJ9 A;  4UOR A;  3NKO A;  3WBH A;  1Y6V A;  3MK1 A;  2W8S A;  5LRM A;  3MK2 A;  2W8D A;  1KH7 A;  1O98 A;  3NVL A;  3UN5 A;  1EQJ A;  5INH A;  1N2L A;  3DYC A;  4KJG A;  4LR9 A;  2QZU A;  3KD8 A;  4LRA A;  3UN3 A;  4GTW A;  3WAW A;  1ELY A;  1URA A;  4MHX A;  4MY4 A;  4ZGA A;  1SHN A;  3TX0 A;  4CXS A;  1B8J A;  3DPC A;  2ANH A;  1KH4 A;  1HQA A;  1KH9 A;  3M8Z A;  1KHL A;  1ANI A;  4LR8 A;  1EW9 A;  1ED8 A;  1URB A;  1K7H A;  1ALK A;  3BDG A;  1KH5 A;  1ELZ A;  2W5X A;  4LQY A;  2D1G A;  2GLQ A;  2GSU A;  3NKM A;  1AJD A;  3NKQ A;  1AUK A;  3MK0 A;  1O99 A;  2W5S A;  4UOO A;  2W5T A;  2XR9 A;  2RH6 A;  5DLT A;  1AJA A;  2GA3 A;  3TWZ A;  4N7T A;  4TN0 A;  3OT9 A;  4CYR A;  5EGE A;  4LR2 A;  3T02 A;  1AJC A;  1ELX A;  3NKN A;  1EI6 A;  1N2K A;  5LIA A;  3CMR A;  2GSO A;  3M7V A;  5L0K A;  1ALJ A;  1EJJ A;  3SZZ A;  3UN2 A;  1ZEF A;  1HJK A;  5GRR A;  5IJQ A;  5KXA A;  2W5Q A;  4KM4 A;  3NKP A;  4CXU A;  5C66 A;  1E2S P;  1ZEB A;  3NKR A;  4LRF A;  1E1Z P;  1KHN A;  1ALH A;  3TG0 A;  4ZG9 A;  4LR7 A;  5EGH A;  4GTX A;  4UPH A;  3LXQ A;  4CXK A;  5L0B A;  1ALI A;  1P49 A;  5L0E A;  4NWX A;  3T00 A;  2XRG A;  4ZG7 A;  3ED4 A;  4FDJ A;  3UO0 A;  3E2D A;  4FDI A;  5LRN A;  4LRC A;  2G9Y A;  3M8W A;  4KJD A;  3WAX A;  5GOV A;  3BDH A;  1KHK A;  3A52 A;  5TJ3 A;  4NWJ A;  3Q3Q A;  1EW2 A;  4QAX A;  1HDH A;  2IUC A;  3BDG B;  5DLW A;  1ANJ A;  4B56 A;  5HRT A;  4MIV A;  3UNY A;  4YR1 A;  3IGY B;  4UPK A;  1E3C P;  2IFY A;  3B5Q A;  1SHQ A;  4KAY A;  4KAV A;  2ZKT A;  4CYS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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