2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
molecule tags Hydrolase
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
4LRDA 2W5XA 1HQAA 5HRTA 1SHNA 4MIVA 3TG0A 1KHKA 4ZG9A 1ALJA 1KH5A 1ELYA 3WAYA 1URAA 2ANHA 4LR9A 5IJQA 5LRMA 4LRAA 4TN0A 3NKNA 1ALIA 3NKRA 2W8DA 4B56A 3UN3A 3WBHA 2GSNA 3BDFA 1HJKA 4UORA 1EW2A 2QZUA 3M8WA 4GTYA 4YR1A 2GSUA 1EJJA 1EI6A 2XRGA 3M8ZA 2GLQA 2G9YA 3Q3QA 4MHXA 4LRFA 1EQJA 3M7VA 4GTZA 3T00A 4GTXA 2W5SA 1KH4A 4KJDA 5DLVA 3NKOA 4N7TA 3UNYA 2ZKTA 1ED8A 3IGZB 4ZGAA 3NVLA 1KHNA 3NKMA 1E2SP 4GTWA 1KH9A 5TJ3A 4UOOA 1B8JA 3MK2A 4LREA 1AJBA 1ZEBA 3A52A 4KM4A 3UN5A 5KXAA 2W8SA 2VQRA 3WAXA 4KJGA 1ANIA 1KHLA 3LXQA 3BDGA 1Y7AA 4CYSA 4LRBA 1EW9A 2IUCA 4CXSA 3BDHA 3MK0A 5AJ9A 2IFYA 5EGHA 1AJDA 1KHJA 1URBA 3OT9A 3KD8A 1ALKA 1ZEDA 4LR2A 1N2LA 4UPKA 3MK1A 1HDHA 1ELXA 1AUKA 1P49A 2W5VA 1E1ZP 3ED4A 5INHA 3SZZA 3WAWA 3DPCA 5GOVA 5K4PA 2W5RA 3UO0A 3SZYA 1E3CP 5IJSA 4NWXA 2D1GA 1K7HA 1KH7A 1ELZA 4LR7A 3DYCA 4NWJA 5L0EA 3B5QA 3BDGB 5L0KA 4FDJA 2W5QA 1ED9A 2W5WA 2GA3A 3NKPA 3UN2A 4UPHA 2X98A 5EGEA 1ALHA 1AJAA 2GSOA 4KAYA 3TX0A 4LQYA 4CYRA 3TWZA 5LQQA 4FDIA 5LIAA 4UPIA 4UOPA 3T02A 1FSUA 4ZG7A 1ZEFA 2RH6A 3E2DA 1EW8A 5LRNA 3M8YA 5DLTA 5C66A 1N2KA 4LR8A 1E33P 3NKQA 5DLWA 3CMRA 1ANJA 4QAXA 2XR9A 3IDDA 1O98A 5GRRA 3T01A 1AJCA 4CXKA 2W5TA 4MY4A 3WAVA 4LRCA 4ZG6A 4UPLA 4KAVA 4CXUA 3IGYB 2IUCB 1O99A 5L0BA 1Y6VA 1SHQA
chains in the Genus database with same CATH superfamily
4LRDA 2W5XA 1HQAA 5HRTA 1SHNA 4MIVA 3TG0A 1KHKA 4ZG9A 1ALJA 1KH5A 1ELYA 3WAYA 1URAA 2ANHA 4LR9A 5IJQA 5LRMA 4LRAA 4TN0A 3NKNA 1ALIA 3NKRA 2W8DA 4B56A 3UN3A 3WBHA 2GSNA 3BDFA 1HJKA 4UORA 1EW2A 2QZUA 3M8WA 4GTYA 4YR1A 2GSUA 1EJJA 1EI6A 2XRGA 3M8ZA 2GLQA 2G9YA 3Q3QA 4MHXA 4LRFA 1EQJA 3M7VA 4GTZA 3T00A 4GTXA 2W5SA 1KH4A 4KJDA 5DLVA 3NKOA 4N7TA 3UNYA 2ZKTA 1ED8A 3IGZB 4ZGAA 3NVLA 1KHNA 3NKMA 1E2SP 4GTWA 1KH9A 5TJ3A 4UOOA 1B8JA 3MK2A 4LREA 1AJBA 1ZEBA 3A52A 4KM4A 3UN5A 5KXAA 2W8SA 2VQRA 3WAXA 4KJGA 1ANIA 1KHLA 3LXQA 3BDGA 1Y7AA 4CYSA 4LRBA 1EW9A 2IUCA 4CXSA 3BDHA 3MK0A 5AJ9A 2IFYA 5EGHA 1AJDA 1KHJA 1URBA 3OT9A 3KD8A 1ALKA 1ZEDA 4LR2A 1N2LA 4UPKA 3MK1A 1HDHA 1ELXA 1AUKA 1P49A 2W5VA 1E1ZP 3ED4A 5INHA 3SZZA 3WAWA 3DPCA 5GOVA 5K4PA 2W5RA 3UO0A 3SZYA 1E3CP 5IJSA 4NWXA 2D1GA 1K7HA 1KH7A 1ELZA 4LR7A 3DYCA 4NWJA 5L0EA 3B5QA 3BDGB 5L0KA 4FDJA 2W5QA 1ED9A 2W5WA 2GA3A 3NKPA 3UN2A 4UPHA 2X98A 5EGEA 1ALHA 1AJAA 2GSOA 4KAYA 3TX0A 4LQYA 4CYRA 3TWZA 5LQQA 4FDIA 5LIAA 4UPIA 4UOPA 3T02A 1FSUA 4ZG7A 1ZEFA 2RH6A 3E2DA 1EW8A 5LRNA 3M8YA 5DLTA 5C66A 1N2KA 4LR8A 1E33P 3NKQA 5DLWA 3CMRA 1ANJA 4QAXA 2XR9A 3IDDA 1O98A 5GRRA 3T01A 1AJCA 4CXKA 2W5TA 4MY4A 3WAVA 4LRCA 4ZG6A 4UPLA 4KAVA 4CXUA 3IGYB 2IUCB 1O99A 5L0BA 1Y6VA 1SHQA
chains in the Genus database with same CATH topology
4LRDA 2W5XA 1HQAA 5HRTA 1SHNA 4MIVA 3TG0A 1KHKA 4ZG9A 1ALJA 1KH5A 1ELYA 3WAYA 1URAA 2ANHA 4LR9A 5IJQA 5LRMA 4LRAA 4TN0A 3NKNA 1ALIA 3NKRA 2W8DA 4B56A 3UN3A 3WBHA 2GSNA 3BDFA 1HJKA 4UORA 1EW2A 2QZUA 3M8WA 4GTYA 4YR1A 2GSUA 1EJJA 1EI6A 2XRGA 3M8ZA 2GLQA 2G9YA 3Q3QA 4MHXA 4LRFA 1EQJA 3M7VA 4GTZA 3T00A 4GTXA 2W5SA 1KH4A 4KJDA 5DLVA 3NKOA 4N7TA 3UNYA 2ZKTA 1ED8A 3IGZB 4ZGAA 3NVLA 1KHNA 3NKMA 1E2SP 4GTWA 1KH9A 5TJ3A 4UOOA 1B8JA 3MK2A 4LREA 1AJBA 1ZEBA 3A52A 4KM4A 3UN5A 5KXAA 2W8SA 2VQRA 3WAXA 4KJGA 1ANIA 1KHLA 3LXQA 3BDGA 1Y7AA 4CYSA 4LRBA 1EW9A 2IUCA 4CXSA 3BDHA 3MK0A 5AJ9A 2IFYA 5EGHA 1AJDA 1KHJA 1URBA 3OT9A 3KD8A 1ALKA 1ZEDA 4LR2A 1N2LA 4UPKA 3MK1A 1HDHA 1ELXA 1AUKA 1P49A 2W5VA 1E1ZP 3ED4A 5INHA 3SZZA 3WAWA 3DPCA 5GOVA 5K4PA 2W5RA 3UO0A 3SZYA 1E3CP 5IJSA 4NWXA 2D1GA 1K7HA 1KH7A 1ELZA 4LR7A 3DYCA 4NWJA 5L0EA 3B5QA 3BDGB 5L0KA 4FDJA 2W5QA 1ED9A 2W5WA 2GA3A 3NKPA 3UN2A 4UPHA 2X98A 5EGEA 1ALHA 1AJAA 2GSOA 4KAYA 3TX0A 4LQYA 4CYRA 3TWZA 5LQQA 4FDIA 5LIAA 4UPIA 4UOPA 3T02A 1FSUA 4ZG7A 1ZEFA 2RH6A 3E2DA 1EW8A 5LRNA 3M8YA 5DLTA 5C66A 1N2KA 4LR8A 1E33P 3NKQA 5DLWA 3CMRA 1ANJA 4QAXA 2XR9A 3IDDA 1O98A 5GRRA 3T01A 1AJCA 4CXKA 2W5TA 4MY4A 3WAVA 4LRCA 4ZG6A 4UPLA 4KAVA 4CXUA 3IGYB 2IUCB 1O99A 5L0BA 1Y6VA 1SHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRD A;  2W5X A;  1HQA A;  5HRT A;  1SHN A;  4MIV A;  3TG0 A;  1KHK A;  4ZG9 A;  1ALJ A;  1KH5 A;  1ELY A;  3WAY A;  1URA A;  2ANH A;  4LR9 A;  5IJQ A;  5LRM A;  4LRA A;  4TN0 A;  3NKN A;  1ALI A;  3NKR A;  2W8D A;  4B56 A;  3UN3 A;  3WBH A;  2GSN A;  3BDF A;  1HJK A;  4UOR A;  1EW2 A;  2QZU A;  3M8W A;  4GTY A;  4YR1 A;  2GSU A;  1EJJ A;  1EI6 A;  2XRG A;  3M8Z A;  2GLQ A;  2G9Y A;  3Q3Q A;  4MHX A;  4LRF A;  1EQJ A;  3M7V A;  4GTZ A;  3T00 A;  4GTX A;  2W5S A;  1KH4 A;  4KJD A;  5DLV A;  3NKO A;  4N7T A;  3UNY A;  2ZKT A;  1ED8 A;  3IGZ B;  4ZGA A;  3NVL A;  1KHN A;  3NKM A;  1E2S P;  4GTW A;  1KH9 A;  5TJ3 A;  4UOO A;  1B8J A;  3MK2 A;  4LRE A;  1AJB A;  1ZEB A;  3A52 A;  4KM4 A;  3UN5 A;  5KXA A;  2W8S A;  2VQR A;  3WAX A;  4KJG A;  1ANI A;  1KHL A;  3LXQ A;  3BDG A;  1Y7A A;  4CYS A;  4LRB A;  1EW9 A;  2IUC A;  4CXS A;  3BDH A;  3MK0 A;  5AJ9 A;  2IFY A;  5EGH A;  1AJD A;  1KHJ A;  1URB A;  3OT9 A;  3KD8 A;  1ALK A;  1ZED A;  4LR2 A;  1N2L A;  4UPK A;  3MK1 A;  1HDH A;  1ELX A;  1AUK A;  1P49 A;  2W5V A;  1E1Z P;  3ED4 A;  5INH A;  3SZZ A;  3WAW A;  3DPC A;  5GOV A;  5K4P A;  2W5R A;  3UO0 A;  3SZY A;  1E3C P;  5IJS A;  4NWX A;  2D1G A;  1K7H A;  1KH7 A;  1ELZ A;  4LR7 A;  3DYC A;  4NWJ A;  5L0E A;  3B5Q A;  3BDG B;  5L0K A;  4FDJ A;  2W5Q A;  1ED9 A;  2W5W A;  2GA3 A;  3NKP A;  3UN2 A;  4UPH A;  2X98 A;  5EGE A;  1ALH A;  1AJA A;  2GSO A;  4KAY A;  3TX0 A;  4LQY A;  4CYR A;  3TWZ A;  5LQQ A;  4FDI A;  5LIA A;  4UPI A;  4UOP A;  3T02 A;  1FSU A;  4ZG7 A;  1ZEF A;  2RH6 A;  3E2D A;  1EW8 A;  5LRN A;  3M8Y A;  5DLT A;  5C66 A;  1N2K A;  4LR8 A;  1E33 P;  3NKQ A;  5DLW A;  3CMR A;  1ANJ A;  4QAX A;  2XR9 A;  3IDD A;  1O98 A;  5GRR A;  3T01 A;  1AJC A;  4CXK A;  2W5T A;  4MY4 A;  3WAV A;  4LRC A;  4ZG6 A;  4UPL A;  4KAV A;  4CXU A;  3IGY B;  2IUC B;  1O99 A;  5L0B A;  1Y6V A;  1SHQ A; 
#chains in the Genus database with same CATH topology
 4LRD A;  2W5X A;  1HQA A;  5HRT A;  1SHN A;  4MIV A;  3TG0 A;  1KHK A;  4ZG9 A;  1ALJ A;  1KH5 A;  1ELY A;  3WAY A;  1URA A;  2ANH A;  4LR9 A;  5IJQ A;  5LRM A;  4LRA A;  4TN0 A;  3NKN A;  1ALI A;  3NKR A;  2W8D A;  4B56 A;  3UN3 A;  3WBH A;  2GSN A;  3BDF A;  1HJK A;  4UOR A;  1EW2 A;  2QZU A;  3M8W A;  4GTY A;  4YR1 A;  2GSU A;  1EJJ A;  1EI6 A;  2XRG A;  3M8Z A;  2GLQ A;  2G9Y A;  3Q3Q A;  4MHX A;  4LRF A;  1EQJ A;  3M7V A;  4GTZ A;  3T00 A;  4GTX A;  2W5S A;  1KH4 A;  4KJD A;  5DLV A;  3NKO A;  4N7T A;  3UNY A;  2ZKT A;  1ED8 A;  3IGZ B;  4ZGA A;  3NVL A;  1KHN A;  3NKM A;  1E2S P;  4GTW A;  1KH9 A;  5TJ3 A;  4UOO A;  1B8J A;  3MK2 A;  4LRE A;  1AJB A;  1ZEB A;  3A52 A;  4KM4 A;  3UN5 A;  5KXA A;  2W8S A;  2VQR A;  3WAX A;  4KJG A;  1ANI A;  1KHL A;  3LXQ A;  3BDG A;  1Y7A A;  4CYS A;  4LRB A;  1EW9 A;  2IUC A;  4CXS A;  3BDH A;  3MK0 A;  5AJ9 A;  2IFY A;  5EGH A;  1AJD A;  1KHJ A;  1URB A;  3OT9 A;  3KD8 A;  1ALK A;  1ZED A;  4LR2 A;  1N2L A;  4UPK A;  3MK1 A;  1HDH A;  1ELX A;  1AUK A;  1P49 A;  2W5V A;  1E1Z P;  3ED4 A;  5INH A;  3SZZ A;  3WAW A;  3DPC A;  5GOV A;  5K4P A;  2W5R A;  3UO0 A;  3SZY A;  1E3C P;  5IJS A;  4NWX A;  2D1G A;  1K7H A;  1KH7 A;  1ELZ A;  4LR7 A;  3DYC A;  4NWJ A;  5L0E A;  3B5Q A;  3BDG B;  5L0K A;  4FDJ A;  2W5Q A;  1ED9 A;  2W5W A;  2GA3 A;  3NKP A;  3UN2 A;  4UPH A;  2X98 A;  5EGE A;  1ALH A;  1AJA A;  2GSO A;  4KAY A;  3TX0 A;  4LQY A;  4CYR A;  3TWZ A;  5LQQ A;  4FDI A;  5LIA A;  4UPI A;  4UOP A;  3T02 A;  1FSU A;  4ZG7 A;  1ZEF A;  2RH6 A;  3E2D A;  1EW8 A;  5LRN A;  3M8Y A;  5DLT A;  5C66 A;  1N2K A;  4LR8 A;  1E33 P;  3NKQ A;  5DLW A;  3CMR A;  1ANJ A;  4QAX A;  2XR9 A;  3IDD A;  1O98 A;  5GRR A;  3T01 A;  1AJC A;  4CXK A;  2W5T A;  4MY4 A;  3WAV A;  4LRC A;  4ZG6 A;  4UPL A;  4KAV A;  4CXU A;  3IGY B;  2IUC B;  1O99 A;  5L0B A;  1Y6V A;  1SHQ A; 
#chains in the Genus database with same CATH homology
 4LRD A;  2W5X A;  1HQA A;  5HRT A;  1SHN A;  4MIV A;  3TG0 A;  1KHK A;  4ZG9 A;  1ALJ A;  1KH5 A;  1ELY A;  3WAY A;  1URA A;  2ANH A;  4LR9 A;  5IJQ A;  5LRM A;  4LRA A;  4TN0 A;  3NKN A;  1ALI A;  3NKR A;  2W8D A;  4B56 A;  3UN3 A;  3WBH A;  2GSN A;  3BDF A;  1HJK A;  4UOR A;  1EW2 A;  2QZU A;  3M8W A;  4GTY A;  4YR1 A;  2GSU A;  1EJJ A;  1EI6 A;  2XRG A;  3M8Z A;  2GLQ A;  2G9Y A;  3Q3Q A;  4MHX A;  4LRF A;  1EQJ A;  3M7V A;  4GTZ A;  3T00 A;  4GTX A;  2W5S A;  1KH4 A;  4KJD A;  5DLV A;  3NKO A;  4N7T A;  3UNY A;  2ZKT A;  1ED8 A;  3IGZ B;  4ZGA A;  3NVL A;  1KHN A;  3NKM A;  1E2S P;  4GTW A;  1KH9 A;  5TJ3 A;  4UOO A;  1B8J A;  3MK2 A;  4LRE A;  1AJB A;  1ZEB A;  3A52 A;  4KM4 A;  3UN5 A;  5KXA A;  2W8S A;  2VQR A;  3WAX A;  4KJG A;  1ANI A;  1KHL A;  3LXQ A;  3BDG A;  1Y7A A;  4CYS A;  4LRB A;  1EW9 A;  2IUC A;  4CXS A;  3BDH A;  3MK0 A;  5AJ9 A;  2IFY A;  5EGH A;  1AJD A;  1KHJ A;  1URB A;  3OT9 A;  3KD8 A;  1ALK A;  1ZED A;  4LR2 A;  1N2L A;  4UPK A;  3MK1 A;  1HDH A;  1ELX A;  1AUK A;  1P49 A;  2W5V A;  1E1Z P;  3ED4 A;  5INH A;  3SZZ A;  3WAW A;  3DPC A;  5GOV A;  5K4P A;  2W5R A;  3UO0 A;  3SZY A;  1E3C P;  5IJS A;  4NWX A;  2D1G A;  1K7H A;  1KH7 A;  1ELZ A;  4LR7 A;  3DYC A;  4NWJ A;  5L0E A;  3B5Q A;  3BDG B;  5L0K A;  4FDJ A;  2W5Q A;  1ED9 A;  2W5W A;  2GA3 A;  3NKP A;  3UN2 A;  4UPH A;  2X98 A;  5EGE A;  1ALH A;  1AJA A;  2GSO A;  4KAY A;  3TX0 A;  4LQY A;  4CYR A;  3TWZ A;  5LQQ A;  4FDI A;  5LIA A;  4UPI A;  4UOP A;  3T02 A;  1FSU A;  4ZG7 A;  1ZEF A;  2RH6 A;  3E2D A;  1EW8 A;  5LRN A;  3M8Y A;  5DLT A;  5C66 A;  1N2K A;  4LR8 A;  1E33 P;  3NKQ A;  5DLW A;  3CMR A;  1ANJ A;  4QAX A;  2XR9 A;  3IDD A;  1O98 A;  5GRR A;  3T01 A;  1AJC A;  4CXK A;  2W5T A;  4MY4 A;  3WAV A;  4LRC A;  4ZG6 A;  4UPL A;  4KAV A;  4CXU A;  3IGY B;  2IUC B;  1O99 A;  5L0B A;  1Y6V A;  1SHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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