2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
1ED8A 2W5VA 3DPCA 1SHQA 3UN3A 3NVLA 3IGYB 4GTWA 3MK0A 2IFYA 4MHXA 5INHA 5IJSA 4KJDA 5L0KA 3MK2A 3WAYA 1B8JA 2GA3A 3NKQA 4LRDA 3WBHA 1HJKA 3T00A 5LRMA 5HRTA 4MY4A 3NKPA 3WAWA 1KHNA 5LIAA 1ANJA 1ELZA 5KXAA 2GSOA 4UOPA 1KH7A 4FDIA 1EI6A 4QAXA 2W5XA 1Y6VA 3KD8A 4UPIA 5EGHA 1E33P 4CYSA 1ED9A 4LRFA 3T02A 3TG0A 3Q3QA 3E2DA 5C66A 3ED4A 2X98A 4ZG7A 5DLTA 2D1GA 4LR8A 3M8ZA 1ZEDA 1EW9A 2XR9A 4LRBA 1E1ZP 4CXUA 3A52A 3M8YA 4CXKA 1ALHA 4LR7A 3UN2A 3CMRA 1FSUA 5DLWA 3B5QA 3M7VA 4ZG9A 3UNYA 5AJ9A 1URAA 4ZGAA 2GLQA 1EW8A 4LREA 1O98A 1EJJA 1ZEFA 3TX0A 1ALKA 1EW2A 2VQRA 2GSUA 1KHKA 1AJDA 3IDDA 4UPLA 4N7TA 5TJ3A 2G9YA 1AUKA 2ANHA 1URBA 3M8WA 4UORA 3LXQA 1HDHA 1K7HA 1N2KA 3BDFA 3T01A 4YR1A 3DYCA 1KH5A 4TN0A 4KJGA 4UPHA 4ZG6A 4CYRA 3BDHA 2IUCB 1HQAA 4LR2A 4NWXA 3SZZA 1ALIA 3NKRA 3NKNA 1ELXA 1O99A 3OT9A 4FDJA 4LR9A 1EQJA 4NWJA 4GTZA 1ZEBA 1AJAA 4KM4A 4LQYA 2W5TA 5K4PA 2W5QA 5GRRA 2XRGA 1ELYA 4UOOA 2W5SA 4UPKA 5L0BA 2GSNA 3UN5A 4CXSA 2IUCA 5LRNA 4LRAA 1ALJA 3IGZB 1ANIA 5L0EA 4MIVA 1KHLA 2W5RA 1Y7AA 2W8DA 1E2SP 4GTYA 3MK1A 3NKMA 4GTXA 4KAVA 1AJBA 1SHNA 1P49A 3SZYA 1KH9A 3UO0A 3NKOA 5GOVA 5DLVA 3TWZA 1KH4A 2ZKTA 2QZUA 5IJQA 2W5WA 3BDGA 3WAVA 4B56A 1E3CP 5LQQA 1N2LA 4LRCA 2RH6A 4KAYA 2W8SA 1AJCA 5EGEA 3WAXA 3BDGB 1KHJA
chains in the Genus database with same CATH superfamily
1ED8A 2W5VA 3DPCA 1SHQA 3UN3A 3NVLA 3IGYB 4GTWA 3MK0A 2IFYA 4MHXA 5INHA 5IJSA 4KJDA 5L0KA 3MK2A 3WAYA 1B8JA 2GA3A 3NKQA 4LRDA 3WBHA 1HJKA 3T00A 5LRMA 5HRTA 4MY4A 3NKPA 3WAWA 1KHNA 5LIAA 1ANJA 1ELZA 5KXAA 2GSOA 4UOPA 1KH7A 4FDIA 1EI6A 4QAXA 2W5XA 1Y6VA 3KD8A 4UPIA 5EGHA 1E33P 4CYSA 1ED9A 4LRFA 3T02A 3TG0A 3Q3QA 3E2DA 5C66A 3ED4A 2X98A 4ZG7A 5DLTA 2D1GA 4LR8A 3M8ZA 1ZEDA 1EW9A 2XR9A 4LRBA 1E1ZP 4CXUA 3A52A 3M8YA 4CXKA 1ALHA 4LR7A 3UN2A 3CMRA 1FSUA 5DLWA 3B5QA 3M7VA 4ZG9A 3UNYA 5AJ9A 1URAA 4ZGAA 2GLQA 1EW8A 4LREA 1O98A 1EJJA 1ZEFA 3TX0A 1ALKA 1EW2A 2VQRA 2GSUA 1KHKA 1AJDA 3IDDA 4UPLA 4N7TA 5TJ3A 2G9YA 1AUKA 2ANHA 1URBA 3M8WA 4UORA 3LXQA 1HDHA 1K7HA 1N2KA 3BDFA 3T01A 4YR1A 3DYCA 1KH5A 4TN0A 4KJGA 4UPHA 4ZG6A 4CYRA 3BDHA 2IUCB 1HQAA 4LR2A 4NWXA 3SZZA 1ALIA 3NKRA 3NKNA 1ELXA 1O99A 3OT9A 4FDJA 4LR9A 1EQJA 4NWJA 4GTZA 1ZEBA 1AJAA 4KM4A 4LQYA 2W5TA 5K4PA 2W5QA 5GRRA 2XRGA 1ELYA 4UOOA 2W5SA 4UPKA 5L0BA 2GSNA 3UN5A 4CXSA 2IUCA 5LRNA 4LRAA 1ALJA 3IGZB 1ANIA 5L0EA 4MIVA 1KHLA 2W5RA 1Y7AA 2W8DA 1E2SP 4GTYA 3MK1A 3NKMA 4GTXA 4KAVA 1AJBA 1SHNA 1P49A 3SZYA 1KH9A 3UO0A 3NKOA 5GOVA 5DLVA 3TWZA 1KH4A 2ZKTA 2QZUA 5IJQA 2W5WA 3BDGA 3WAVA 4B56A 1E3CP 5LQQA 1N2LA 4LRCA 2RH6A 4KAYA 2W8SA 1AJCA 5EGEA 3WAXA 3BDGB 1KHJA
chains in the Genus database with same CATH topology
1ED8A 2W5VA 3DPCA 1SHQA 3UN3A 3NVLA 3IGYB 4GTWA 3MK0A 2IFYA 4MHXA 5INHA 5IJSA 4KJDA 5L0KA 3MK2A 3WAYA 1B8JA 2GA3A 3NKQA 4LRDA 3WBHA 1HJKA 3T00A 5LRMA 5HRTA 4MY4A 3NKPA 3WAWA 1KHNA 5LIAA 1ANJA 1ELZA 5KXAA 2GSOA 4UOPA 1KH7A 4FDIA 1EI6A 4QAXA 2W5XA 1Y6VA 3KD8A 4UPIA 5EGHA 1E33P 4CYSA 1ED9A 4LRFA 3T02A 3TG0A 3Q3QA 3E2DA 5C66A 3ED4A 2X98A 4ZG7A 5DLTA 2D1GA 4LR8A 3M8ZA 1ZEDA 1EW9A 2XR9A 4LRBA 1E1ZP 4CXUA 3A52A 3M8YA 4CXKA 1ALHA 4LR7A 3UN2A 3CMRA 1FSUA 5DLWA 3B5QA 3M7VA 4ZG9A 3UNYA 5AJ9A 1URAA 4ZGAA 2GLQA 1EW8A 4LREA 1O98A 1EJJA 1ZEFA 3TX0A 1ALKA 1EW2A 2VQRA 2GSUA 1KHKA 1AJDA 3IDDA 4UPLA 4N7TA 5TJ3A 2G9YA 1AUKA 2ANHA 1URBA 3M8WA 4UORA 3LXQA 1HDHA 1K7HA 1N2KA 3BDFA 3T01A 4YR1A 3DYCA 1KH5A 4TN0A 4KJGA 4UPHA 4ZG6A 4CYRA 3BDHA 2IUCB 1HQAA 4LR2A 4NWXA 3SZZA 1ALIA 3NKRA 3NKNA 1ELXA 1O99A 3OT9A 4FDJA 4LR9A 1EQJA 4NWJA 4GTZA 1ZEBA 1AJAA 4KM4A 4LQYA 2W5TA 5K4PA 2W5QA 5GRRA 2XRGA 1ELYA 4UOOA 2W5SA 4UPKA 5L0BA 2GSNA 3UN5A 4CXSA 2IUCA 5LRNA 4LRAA 1ALJA 3IGZB 1ANIA 5L0EA 4MIVA 1KHLA 2W5RA 1Y7AA 2W8DA 1E2SP 4GTYA 3MK1A 3NKMA 4GTXA 4KAVA 1AJBA 1SHNA 1P49A 3SZYA 1KH9A 3UO0A 3NKOA 5GOVA 5DLVA 3TWZA 1KH4A 2ZKTA 2QZUA 5IJQA 2W5WA 3BDGA 3WAVA 4B56A 1E3CP 5LQQA 1N2LA 4LRCA 2RH6A 4KAYA 2W8SA 1AJCA 5EGEA 3WAXA 3BDGB 1KHJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED8 A;  2W5V A;  3DPC A;  1SHQ A;  3UN3 A;  3NVL A;  3IGY B;  4GTW A;  3MK0 A;  2IFY A;  4MHX A;  5INH A;  5IJS A;  4KJD A;  5L0K A;  3MK2 A;  3WAY A;  1B8J A;  2GA3 A;  3NKQ A;  4LRD A;  3WBH A;  1HJK A;  3T00 A;  5LRM A;  5HRT A;  4MY4 A;  3NKP A;  3WAW A;  1KHN A;  5LIA A;  1ANJ A;  1ELZ A;  5KXA A;  2GSO A;  4UOP A;  1KH7 A;  4FDI A;  1EI6 A;  4QAX A;  2W5X A;  1Y6V A;  3KD8 A;  4UPI A;  5EGH A;  1E33 P;  4CYS A;  1ED9 A;  4LRF A;  3T02 A;  3TG0 A;  3Q3Q A;  3E2D A;  5C66 A;  3ED4 A;  2X98 A;  4ZG7 A;  5DLT A;  2D1G A;  4LR8 A;  3M8Z A;  1ZED A;  1EW9 A;  2XR9 A;  4LRB A;  1E1Z P;  4CXU A;  3A52 A;  3M8Y A;  4CXK A;  1ALH A;  4LR7 A;  3UN2 A;  3CMR A;  1FSU A;  5DLW A;  3B5Q A;  3M7V A;  4ZG9 A;  3UNY A;  5AJ9 A;  1URA A;  4ZGA A;  2GLQ A;  1EW8 A;  4LRE A;  1O98 A;  1EJJ A;  1ZEF A;  3TX0 A;  1ALK A;  1EW2 A;  2VQR A;  2GSU A;  1KHK A;  1AJD A;  3IDD A;  4UPL A;  4N7T A;  5TJ3 A;  2G9Y A;  1AUK A;  2ANH A;  1URB A;  3M8W A;  4UOR A;  3LXQ A;  1HDH A;  1K7H A;  1N2K A;  3BDF A;  3T01 A;  4YR1 A;  3DYC A;  1KH5 A;  4TN0 A;  4KJG A;  4UPH A;  4ZG6 A;  4CYR A;  3BDH A;  2IUC B;  1HQA A;  4LR2 A;  4NWX A;  3SZZ A;  1ALI A;  3NKR A;  3NKN A;  1ELX A;  1O99 A;  3OT9 A;  4FDJ A;  4LR9 A;  1EQJ A;  4NWJ A;  4GTZ A;  1ZEB A;  1AJA A;  4KM4 A;  4LQY A;  2W5T A;  5K4P A;  2W5Q A;  5GRR A;  2XRG A;  1ELY A;  4UOO A;  2W5S A;  4UPK A;  5L0B A;  2GSN A;  3UN5 A;  4CXS A;  2IUC A;  5LRN A;  4LRA A;  1ALJ A;  3IGZ B;  1ANI A;  5L0E A;  4MIV A;  1KHL A;  2W5R A;  1Y7A A;  2W8D A;  1E2S P;  4GTY A;  3MK1 A;  3NKM A;  4GTX A;  4KAV A;  1AJB A;  1SHN A;  1P49 A;  3SZY A;  1KH9 A;  3UO0 A;  3NKO A;  5GOV A;  5DLV A;  3TWZ A;  1KH4 A;  2ZKT A;  2QZU A;  5IJQ A;  2W5W A;  3BDG A;  3WAV A;  4B56 A;  1E3C P;  5LQQ A;  1N2L A;  4LRC A;  2RH6 A;  4KAY A;  2W8S A;  1AJC A;  5EGE A;  3WAX A;  3BDG B;  1KHJ A; 
#chains in the Genus database with same CATH topology
 1ED8 A;  2W5V A;  3DPC A;  1SHQ A;  3UN3 A;  3NVL A;  3IGY B;  4GTW A;  3MK0 A;  2IFY A;  4MHX A;  5INH A;  5IJS A;  4KJD A;  5L0K A;  3MK2 A;  3WAY A;  1B8J A;  2GA3 A;  3NKQ A;  4LRD A;  3WBH A;  1HJK A;  3T00 A;  5LRM A;  5HRT A;  4MY4 A;  3NKP A;  3WAW A;  1KHN A;  5LIA A;  1ANJ A;  1ELZ A;  5KXA A;  2GSO A;  4UOP A;  1KH7 A;  4FDI A;  1EI6 A;  4QAX A;  2W5X A;  1Y6V A;  3KD8 A;  4UPI A;  5EGH A;  1E33 P;  4CYS A;  1ED9 A;  4LRF A;  3T02 A;  3TG0 A;  3Q3Q A;  3E2D A;  5C66 A;  3ED4 A;  2X98 A;  4ZG7 A;  5DLT A;  2D1G A;  4LR8 A;  3M8Z A;  1ZED A;  1EW9 A;  2XR9 A;  4LRB A;  1E1Z P;  4CXU A;  3A52 A;  3M8Y A;  4CXK A;  1ALH A;  4LR7 A;  3UN2 A;  3CMR A;  1FSU A;  5DLW A;  3B5Q A;  3M7V A;  4ZG9 A;  3UNY A;  5AJ9 A;  1URA A;  4ZGA A;  2GLQ A;  1EW8 A;  4LRE A;  1O98 A;  1EJJ A;  1ZEF A;  3TX0 A;  1ALK A;  1EW2 A;  2VQR A;  2GSU A;  1KHK A;  1AJD A;  3IDD A;  4UPL A;  4N7T A;  5TJ3 A;  2G9Y A;  1AUK A;  2ANH A;  1URB A;  3M8W A;  4UOR A;  3LXQ A;  1HDH A;  1K7H A;  1N2K A;  3BDF A;  3T01 A;  4YR1 A;  3DYC A;  1KH5 A;  4TN0 A;  4KJG A;  4UPH A;  4ZG6 A;  4CYR A;  3BDH A;  2IUC B;  1HQA A;  4LR2 A;  4NWX A;  3SZZ A;  1ALI A;  3NKR A;  3NKN A;  1ELX A;  1O99 A;  3OT9 A;  4FDJ A;  4LR9 A;  1EQJ A;  4NWJ A;  4GTZ A;  1ZEB A;  1AJA A;  4KM4 A;  4LQY A;  2W5T A;  5K4P A;  2W5Q A;  5GRR A;  2XRG A;  1ELY A;  4UOO A;  2W5S A;  4UPK A;  5L0B A;  2GSN A;  3UN5 A;  4CXS A;  2IUC A;  5LRN A;  4LRA A;  1ALJ A;  3IGZ B;  1ANI A;  5L0E A;  4MIV A;  1KHL A;  2W5R A;  1Y7A A;  2W8D A;  1E2S P;  4GTY A;  3MK1 A;  3NKM A;  4GTX A;  4KAV A;  1AJB A;  1SHN A;  1P49 A;  3SZY A;  1KH9 A;  3UO0 A;  3NKO A;  5GOV A;  5DLV A;  3TWZ A;  1KH4 A;  2ZKT A;  2QZU A;  5IJQ A;  2W5W A;  3BDG A;  3WAV A;  4B56 A;  1E3C P;  5LQQ A;  1N2L A;  4LRC A;  2RH6 A;  4KAY A;  2W8S A;  1AJC A;  5EGE A;  3WAX A;  3BDG B;  1KHJ A; 
#chains in the Genus database with same CATH homology
 1ED8 A;  2W5V A;  3DPC A;  1SHQ A;  3UN3 A;  3NVL A;  3IGY B;  4GTW A;  3MK0 A;  2IFY A;  4MHX A;  5INH A;  5IJS A;  4KJD A;  5L0K A;  3MK2 A;  3WAY A;  1B8J A;  2GA3 A;  3NKQ A;  4LRD A;  3WBH A;  1HJK A;  3T00 A;  5LRM A;  5HRT A;  4MY4 A;  3NKP A;  3WAW A;  1KHN A;  5LIA A;  1ANJ A;  1ELZ A;  5KXA A;  2GSO A;  4UOP A;  1KH7 A;  4FDI A;  1EI6 A;  4QAX A;  2W5X A;  1Y6V A;  3KD8 A;  4UPI A;  5EGH A;  1E33 P;  4CYS A;  1ED9 A;  4LRF A;  3T02 A;  3TG0 A;  3Q3Q A;  3E2D A;  5C66 A;  3ED4 A;  2X98 A;  4ZG7 A;  5DLT A;  2D1G A;  4LR8 A;  3M8Z A;  1ZED A;  1EW9 A;  2XR9 A;  4LRB A;  1E1Z P;  4CXU A;  3A52 A;  3M8Y A;  4CXK A;  1ALH A;  4LR7 A;  3UN2 A;  3CMR A;  1FSU A;  5DLW A;  3B5Q A;  3M7V A;  4ZG9 A;  3UNY A;  5AJ9 A;  1URA A;  4ZGA A;  2GLQ A;  1EW8 A;  4LRE A;  1O98 A;  1EJJ A;  1ZEF A;  3TX0 A;  1ALK A;  1EW2 A;  2VQR A;  2GSU A;  1KHK A;  1AJD A;  3IDD A;  4UPL A;  4N7T A;  5TJ3 A;  2G9Y A;  1AUK A;  2ANH A;  1URB A;  3M8W A;  4UOR A;  3LXQ A;  1HDH A;  1K7H A;  1N2K A;  3BDF A;  3T01 A;  4YR1 A;  3DYC A;  1KH5 A;  4TN0 A;  4KJG A;  4UPH A;  4ZG6 A;  4CYR A;  3BDH A;  2IUC B;  1HQA A;  4LR2 A;  4NWX A;  3SZZ A;  1ALI A;  3NKR A;  3NKN A;  1ELX A;  1O99 A;  3OT9 A;  4FDJ A;  4LR9 A;  1EQJ A;  4NWJ A;  4GTZ A;  1ZEB A;  1AJA A;  4KM4 A;  4LQY A;  2W5T A;  5K4P A;  2W5Q A;  5GRR A;  2XRG A;  1ELY A;  4UOO A;  2W5S A;  4UPK A;  5L0B A;  2GSN A;  3UN5 A;  4CXS A;  2IUC A;  5LRN A;  4LRA A;  1ALJ A;  3IGZ B;  1ANI A;  5L0E A;  4MIV A;  1KHL A;  2W5R A;  1Y7A A;  2W8D A;  1E2S P;  4GTY A;  3MK1 A;  3NKM A;  4GTX A;  4KAV A;  1AJB A;  1SHN A;  1P49 A;  3SZY A;  1KH9 A;  3UO0 A;  3NKO A;  5GOV A;  5DLV A;  3TWZ A;  1KH4 A;  2ZKT A;  2QZU A;  5IJQ A;  2W5W A;  3BDG A;  3WAV A;  4B56 A;  1E3C P;  5LQQ A;  1N2L A;  4LRC A;  2RH6 A;  4KAY A;  2W8S A;  1AJC A;  5EGE A;  3WAX A;  3BDG B;  1KHJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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