2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
5LQQA 1P49A 4LREA 1ZEDA 4CYRA 5HRTA 1KHNA 3NKNA 1ALHA 1O98A 4ZG6A 4KJDA 1ELYA 1EJJA 1ZEBA 2W5VA 3WBHA 1SHNA 3IGYB 3DYCA 3NKRA 3BDHA 2W8SA 3MK0A 4ZG9A 3E2DA 1HDHA 1N2KA 1EW8A 4N7TA 3WAWA 4FDJA 2GSUA 4KJGA 3T00A 5LIAA 2W5QA 4ZGAA 5KXAA 3UNYA 5EGHA 1ED8A 3KD8A 3DPCA 1Y6VA 1SHQA 3UN5A 2ZKTA 4KAVA 4LRAA 4LR8A 2IUCA 1KHJA 2W5WA 3NKQA 2XRGA 4MHXA 4UOOA 2GA3A 5TJ3A 3WAVA 3NKMA 3CMRA 1KH4A 3MK2A 2W5RA 2W5TA 4FDIA 2IFYA 4MIVA 1ALKA 1AJBA 4GTYA 3M7VA 1EQJA 5GOVA 5L0BA 2GSNA 5DLWA 1AUKA 3A52A 3SZZA 4LRDA 3OT9A 2GSOA 1ANJA 3NVLA 1K7HA 4UPKA 3TG0A 3IGZB 3NKPA 3UN3A 2D1GA 1ANIA 3ED4A 1E3CP 3UO0A 4MY4A 2W5XA 4GTWA 4LRBA 4CXSA 5INHA 1N2LA 4UORA 1FSUA 5DLTA 4UOPA 3M8WA 1EW2A 5L0KA 1EI6A 4LR9A 3SZYA 3M8YA 4CXKA 4UPIA 5DLVA 4LR2A 1AJAA 1ALJA 4UPHA 3BDFA 4LR7A 4KM4A 4UPLA 3B5QA 1O99A 1URBA 3BDGB 1B8JA 2ANHA 2XR9A 5GRRA 3TX0A 1E2SP 2RH6A 3Q3QA 5K4PA 1AJDA 2IUCB 3UN2A 5L0EA 4NWXA 2GLQA 1KH9A 2W8DA 3NKOA 1KH7A 2W5SA 4TN0A 4LRFA 5IJQA 2VQRA 4LQYA 3WAYA 1ED9A 3T01A 5IJSA 1E33P 4YR1A 4CYSA 5EGEA 4GTXA 1ELXA 1ALIA 1ELZA 3LXQA 5LRNA 4ZG7A 3M8ZA 4QAXA 1KHKA 3BDGA 4CXUA 3MK1A 1KH5A 1E1ZP 3TWZA 4GTZA 3WAXA 1HJKA 1EW9A 3IDDA 1URAA 1HQAA 3T02A 1ZEFA 2G9YA 1Y7AA 2X98A 4B56A 1KHLA 5AJ9A 4KAYA 4LRCA 2QZUA 4NWJA 5C66A 5LRMA 1AJCA
chains in the Genus database with same CATH superfamily
5LQQA 1P49A 4LREA 1ZEDA 4CYRA 5HRTA 1KHNA 3NKNA 1ALHA 1O98A 4ZG6A 4KJDA 1ELYA 1EJJA 1ZEBA 2W5VA 3WBHA 1SHNA 3IGYB 3DYCA 3NKRA 3BDHA 2W8SA 3MK0A 4ZG9A 3E2DA 1HDHA 1N2KA 1EW8A 4N7TA 3WAWA 4FDJA 2GSUA 4KJGA 3T00A 5LIAA 2W5QA 4ZGAA 5KXAA 3UNYA 5EGHA 1ED8A 3KD8A 3DPCA 1Y6VA 1SHQA 3UN5A 2ZKTA 4KAVA 4LRAA 4LR8A 2IUCA 1KHJA 2W5WA 3NKQA 2XRGA 4MHXA 4UOOA 2GA3A 5TJ3A 3WAVA 3NKMA 3CMRA 1KH4A 3MK2A 2W5RA 2W5TA 4FDIA 2IFYA 4MIVA 1ALKA 1AJBA 4GTYA 3M7VA 1EQJA 5GOVA 5L0BA 2GSNA 5DLWA 1AUKA 3A52A 3SZZA 4LRDA 3OT9A 2GSOA 1ANJA 3NVLA 1K7HA 4UPKA 3TG0A 3IGZB 3NKPA 3UN3A 2D1GA 1ANIA 3ED4A 1E3CP 3UO0A 4MY4A 2W5XA 4GTWA 4LRBA 4CXSA 5INHA 1N2LA 4UORA 1FSUA 5DLTA 4UOPA 3M8WA 1EW2A 5L0KA 1EI6A 4LR9A 3SZYA 3M8YA 4CXKA 4UPIA 5DLVA 4LR2A 1AJAA 1ALJA 4UPHA 3BDFA 4LR7A 4KM4A 4UPLA 3B5QA 1O99A 1URBA 3BDGB 1B8JA 2ANHA 2XR9A 5GRRA 3TX0A 1E2SP 2RH6A 3Q3QA 5K4PA 1AJDA 2IUCB 3UN2A 5L0EA 4NWXA 2GLQA 1KH9A 2W8DA 3NKOA 1KH7A 2W5SA 4TN0A 4LRFA 5IJQA 2VQRA 4LQYA 3WAYA 1ED9A 3T01A 5IJSA 1E33P 4YR1A 4CYSA 5EGEA 4GTXA 1ELXA 1ALIA 1ELZA 3LXQA 5LRNA 4ZG7A 3M8ZA 4QAXA 1KHKA 3BDGA 4CXUA 3MK1A 1KH5A 1E1ZP 3TWZA 4GTZA 3WAXA 1HJKA 1EW9A 3IDDA 1URAA 1HQAA 3T02A 1ZEFA 2G9YA 1Y7AA 2X98A 4B56A 1KHLA 5AJ9A 4KAYA 4LRCA 2QZUA 4NWJA 5C66A 5LRMA 1AJCA
chains in the Genus database with same CATH topology
5LQQA 1P49A 4LREA 1ZEDA 4CYRA 5HRTA 1KHNA 3NKNA 1ALHA 1O98A 4ZG6A 4KJDA 1ELYA 1EJJA 1ZEBA 2W5VA 3WBHA 1SHNA 3IGYB 3DYCA 3NKRA 3BDHA 2W8SA 3MK0A 4ZG9A 3E2DA 1HDHA 1N2KA 1EW8A 4N7TA 3WAWA 4FDJA 2GSUA 4KJGA 3T00A 5LIAA 2W5QA 4ZGAA 5KXAA 3UNYA 5EGHA 1ED8A 3KD8A 3DPCA 1Y6VA 1SHQA 3UN5A 2ZKTA 4KAVA 4LRAA 4LR8A 2IUCA 1KHJA 2W5WA 3NKQA 2XRGA 4MHXA 4UOOA 2GA3A 5TJ3A 3WAVA 3NKMA 3CMRA 1KH4A 3MK2A 2W5RA 2W5TA 4FDIA 2IFYA 4MIVA 1ALKA 1AJBA 4GTYA 3M7VA 1EQJA 5GOVA 5L0BA 2GSNA 5DLWA 1AUKA 3A52A 3SZZA 4LRDA 3OT9A 2GSOA 1ANJA 3NVLA 1K7HA 4UPKA 3TG0A 3IGZB 3NKPA 3UN3A 2D1GA 1ANIA 3ED4A 1E3CP 3UO0A 4MY4A 2W5XA 4GTWA 4LRBA 4CXSA 5INHA 1N2LA 4UORA 1FSUA 5DLTA 4UOPA 3M8WA 1EW2A 5L0KA 1EI6A 4LR9A 3SZYA 3M8YA 4CXKA 4UPIA 5DLVA 4LR2A 1AJAA 1ALJA 4UPHA 3BDFA 4LR7A 4KM4A 4UPLA 3B5QA 1O99A 1URBA 3BDGB 1B8JA 2ANHA 2XR9A 5GRRA 3TX0A 1E2SP 2RH6A 3Q3QA 5K4PA 1AJDA 2IUCB 3UN2A 5L0EA 4NWXA 2GLQA 1KH9A 2W8DA 3NKOA 1KH7A 2W5SA 4TN0A 4LRFA 5IJQA 2VQRA 4LQYA 3WAYA 1ED9A 3T01A 5IJSA 1E33P 4YR1A 4CYSA 5EGEA 4GTXA 1ELXA 1ALIA 1ELZA 3LXQA 5LRNA 4ZG7A 3M8ZA 4QAXA 1KHKA 3BDGA 4CXUA 3MK1A 1KH5A 1E1ZP 3TWZA 4GTZA 3WAXA 1HJKA 1EW9A 3IDDA 1URAA 1HQAA 3T02A 1ZEFA 2G9YA 1Y7AA 2X98A 4B56A 1KHLA 5AJ9A 4KAYA 4LRCA 2QZUA 4NWJA 5C66A 5LRMA 1AJCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LQQ A;  1P49 A;  4LRE A;  1ZED A;  4CYR A;  5HRT A;  1KHN A;  3NKN A;  1ALH A;  1O98 A;  4ZG6 A;  4KJD A;  1ELY A;  1EJJ A;  1ZEB A;  2W5V A;  3WBH A;  1SHN A;  3IGY B;  3DYC A;  3NKR A;  3BDH A;  2W8S A;  3MK0 A;  4ZG9 A;  3E2D A;  1HDH A;  1N2K A;  1EW8 A;  4N7T A;  3WAW A;  4FDJ A;  2GSU A;  4KJG A;  3T00 A;  5LIA A;  2W5Q A;  4ZGA A;  5KXA A;  3UNY A;  5EGH A;  1ED8 A;  3KD8 A;  3DPC A;  1Y6V A;  1SHQ A;  3UN5 A;  2ZKT A;  4KAV A;  4LRA A;  4LR8 A;  2IUC A;  1KHJ A;  2W5W A;  3NKQ A;  2XRG A;  4MHX A;  4UOO A;  2GA3 A;  5TJ3 A;  3WAV A;  3NKM A;  3CMR A;  1KH4 A;  3MK2 A;  2W5R A;  2W5T A;  4FDI A;  2IFY A;  4MIV A;  1ALK A;  1AJB A;  4GTY A;  3M7V A;  1EQJ A;  5GOV A;  5L0B A;  2GSN A;  5DLW A;  1AUK A;  3A52 A;  3SZZ A;  4LRD A;  3OT9 A;  2GSO A;  1ANJ A;  3NVL A;  1K7H A;  4UPK A;  3TG0 A;  3IGZ B;  3NKP A;  3UN3 A;  2D1G A;  1ANI A;  3ED4 A;  1E3C P;  3UO0 A;  4MY4 A;  2W5X A;  4GTW A;  4LRB A;  4CXS A;  5INH A;  1N2L A;  4UOR A;  1FSU A;  5DLT A;  4UOP A;  3M8W A;  1EW2 A;  5L0K A;  1EI6 A;  4LR9 A;  3SZY A;  3M8Y A;  4CXK A;  4UPI A;  5DLV A;  4LR2 A;  1AJA A;  1ALJ A;  4UPH A;  3BDF A;  4LR7 A;  4KM4 A;  4UPL A;  3B5Q A;  1O99 A;  1URB A;  3BDG B;  1B8J A;  2ANH A;  2XR9 A;  5GRR A;  3TX0 A;  1E2S P;  2RH6 A;  3Q3Q A;  5K4P A;  1AJD A;  2IUC B;  3UN2 A;  5L0E A;  4NWX A;  2GLQ A;  1KH9 A;  2W8D A;  3NKO A;  1KH7 A;  2W5S A;  4TN0 A;  4LRF A;  5IJQ A;  2VQR A;  4LQY A;  3WAY A;  1ED9 A;  3T01 A;  5IJS A;  1E33 P;  4YR1 A;  4CYS A;  5EGE A;  4GTX A;  1ELX A;  1ALI A;  1ELZ A;  3LXQ A;  5LRN A;  4ZG7 A;  3M8Z A;  4QAX A;  1KHK A;  3BDG A;  4CXU A;  3MK1 A;  1KH5 A;  1E1Z P;  3TWZ A;  4GTZ A;  3WAX A;  1HJK A;  1EW9 A;  3IDD A;  1URA A;  1HQA A;  3T02 A;  1ZEF A;  2G9Y A;  1Y7A A;  2X98 A;  4B56 A;  1KHL A;  5AJ9 A;  4KAY A;  4LRC A;  2QZU A;  4NWJ A;  5C66 A;  5LRM A;  1AJC A; 
#chains in the Genus database with same CATH topology
 5LQQ A;  1P49 A;  4LRE A;  1ZED A;  4CYR A;  5HRT A;  1KHN A;  3NKN A;  1ALH A;  1O98 A;  4ZG6 A;  4KJD A;  1ELY A;  1EJJ A;  1ZEB A;  2W5V A;  3WBH A;  1SHN A;  3IGY B;  3DYC A;  3NKR A;  3BDH A;  2W8S A;  3MK0 A;  4ZG9 A;  3E2D A;  1HDH A;  1N2K A;  1EW8 A;  4N7T A;  3WAW A;  4FDJ A;  2GSU A;  4KJG A;  3T00 A;  5LIA A;  2W5Q A;  4ZGA A;  5KXA A;  3UNY A;  5EGH A;  1ED8 A;  3KD8 A;  3DPC A;  1Y6V A;  1SHQ A;  3UN5 A;  2ZKT A;  4KAV A;  4LRA A;  4LR8 A;  2IUC A;  1KHJ A;  2W5W A;  3NKQ A;  2XRG A;  4MHX A;  4UOO A;  2GA3 A;  5TJ3 A;  3WAV A;  3NKM A;  3CMR A;  1KH4 A;  3MK2 A;  2W5R A;  2W5T A;  4FDI A;  2IFY A;  4MIV A;  1ALK A;  1AJB A;  4GTY A;  3M7V A;  1EQJ A;  5GOV A;  5L0B A;  2GSN A;  5DLW A;  1AUK A;  3A52 A;  3SZZ A;  4LRD A;  3OT9 A;  2GSO A;  1ANJ A;  3NVL A;  1K7H A;  4UPK A;  3TG0 A;  3IGZ B;  3NKP A;  3UN3 A;  2D1G A;  1ANI A;  3ED4 A;  1E3C P;  3UO0 A;  4MY4 A;  2W5X A;  4GTW A;  4LRB A;  4CXS A;  5INH A;  1N2L A;  4UOR A;  1FSU A;  5DLT A;  4UOP A;  3M8W A;  1EW2 A;  5L0K A;  1EI6 A;  4LR9 A;  3SZY A;  3M8Y A;  4CXK A;  4UPI A;  5DLV A;  4LR2 A;  1AJA A;  1ALJ A;  4UPH A;  3BDF A;  4LR7 A;  4KM4 A;  4UPL A;  3B5Q A;  1O99 A;  1URB A;  3BDG B;  1B8J A;  2ANH A;  2XR9 A;  5GRR A;  3TX0 A;  1E2S P;  2RH6 A;  3Q3Q A;  5K4P A;  1AJD A;  2IUC B;  3UN2 A;  5L0E A;  4NWX A;  2GLQ A;  1KH9 A;  2W8D A;  3NKO A;  1KH7 A;  2W5S A;  4TN0 A;  4LRF A;  5IJQ A;  2VQR A;  4LQY A;  3WAY A;  1ED9 A;  3T01 A;  5IJS A;  1E33 P;  4YR1 A;  4CYS A;  5EGE A;  4GTX A;  1ELX A;  1ALI A;  1ELZ A;  3LXQ A;  5LRN A;  4ZG7 A;  3M8Z A;  4QAX A;  1KHK A;  3BDG A;  4CXU A;  3MK1 A;  1KH5 A;  1E1Z P;  3TWZ A;  4GTZ A;  3WAX A;  1HJK A;  1EW9 A;  3IDD A;  1URA A;  1HQA A;  3T02 A;  1ZEF A;  2G9Y A;  1Y7A A;  2X98 A;  4B56 A;  1KHL A;  5AJ9 A;  4KAY A;  4LRC A;  2QZU A;  4NWJ A;  5C66 A;  5LRM A;  1AJC A; 
#chains in the Genus database with same CATH homology
 5LQQ A;  1P49 A;  4LRE A;  1ZED A;  4CYR A;  5HRT A;  1KHN A;  3NKN A;  1ALH A;  1O98 A;  4ZG6 A;  4KJD A;  1ELY A;  1EJJ A;  1ZEB A;  2W5V A;  3WBH A;  1SHN A;  3IGY B;  3DYC A;  3NKR A;  3BDH A;  2W8S A;  3MK0 A;  4ZG9 A;  3E2D A;  1HDH A;  1N2K A;  1EW8 A;  4N7T A;  3WAW A;  4FDJ A;  2GSU A;  4KJG A;  3T00 A;  5LIA A;  2W5Q A;  4ZGA A;  5KXA A;  3UNY A;  5EGH A;  1ED8 A;  3KD8 A;  3DPC A;  1Y6V A;  1SHQ A;  3UN5 A;  2ZKT A;  4KAV A;  4LRA A;  4LR8 A;  2IUC A;  1KHJ A;  2W5W A;  3NKQ A;  2XRG A;  4MHX A;  4UOO A;  2GA3 A;  5TJ3 A;  3WAV A;  3NKM A;  3CMR A;  1KH4 A;  3MK2 A;  2W5R A;  2W5T A;  4FDI A;  2IFY A;  4MIV A;  1ALK A;  1AJB A;  4GTY A;  3M7V A;  1EQJ A;  5GOV A;  5L0B A;  2GSN A;  5DLW A;  1AUK A;  3A52 A;  3SZZ A;  4LRD A;  3OT9 A;  2GSO A;  1ANJ A;  3NVL A;  1K7H A;  4UPK A;  3TG0 A;  3IGZ B;  3NKP A;  3UN3 A;  2D1G A;  1ANI A;  3ED4 A;  1E3C P;  3UO0 A;  4MY4 A;  2W5X A;  4GTW A;  4LRB A;  4CXS A;  5INH A;  1N2L A;  4UOR A;  1FSU A;  5DLT A;  4UOP A;  3M8W A;  1EW2 A;  5L0K A;  1EI6 A;  4LR9 A;  3SZY A;  3M8Y A;  4CXK A;  4UPI A;  5DLV A;  4LR2 A;  1AJA A;  1ALJ A;  4UPH A;  3BDF A;  4LR7 A;  4KM4 A;  4UPL A;  3B5Q A;  1O99 A;  1URB A;  3BDG B;  1B8J A;  2ANH A;  2XR9 A;  5GRR A;  3TX0 A;  1E2S P;  2RH6 A;  3Q3Q A;  5K4P A;  1AJD A;  2IUC B;  3UN2 A;  5L0E A;  4NWX A;  2GLQ A;  1KH9 A;  2W8D A;  3NKO A;  1KH7 A;  2W5S A;  4TN0 A;  4LRF A;  5IJQ A;  2VQR A;  4LQY A;  3WAY A;  1ED9 A;  3T01 A;  5IJS A;  1E33 P;  4YR1 A;  4CYS A;  5EGE A;  4GTX A;  1ELX A;  1ALI A;  1ELZ A;  3LXQ A;  5LRN A;  4ZG7 A;  3M8Z A;  4QAX A;  1KHK A;  3BDG A;  4CXU A;  3MK1 A;  1KH5 A;  1E1Z P;  3TWZ A;  4GTZ A;  3WAX A;  1HJK A;  1EW9 A;  3IDD A;  1URA A;  1HQA A;  3T02 A;  1ZEF A;  2G9Y A;  1Y7A A;  2X98 A;  4B56 A;  1KHL A;  5AJ9 A;  4KAY A;  4LRC A;  2QZU A;  4NWJ A;  5C66 A;  5LRM A;  1AJC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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