2GLQA

X-ray structure of human alkaline phosphatase in complex with strontium
Total Genus 172
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
172
Knots found
sequence length
479
structure length
478
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
publication title Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
pubmed doi rcsb
total genus 172
structure length 478
sequence length 479
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2006-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2glqA00
3BDHA 5AJ9A 1ALJA 5EGHA 4KJGA 4LREA 1KHNA 1HQAA 4LR2A 3M7VA 4LRAA 1URBA 4UPIA 2QZUA 4MY4A 3TWZA 4UORA 4LRBA 2GSUA 5EGEA 3NKMA 4TN0A 3MK1A 3MK2A 2IFYA 3SZYA 3MK0A 4UPHA 3WAVA 1KHLA 1KH4A 3BDGA 3TX0A 5GRRA 2W5QA 2W5SA 4YR1A 1E3CP 4CXKA 1ELYA 2W5WA 4GTXA 3DPCA 3NKNA 4CYSA 5LRMA 3SZZA 2D1GA 4GTWA 3T00A 5LRNA 1AJDA 3IGZB 5IJSA 2IUCB 4KAVA 2W5TA 2GSOA 5GOVA 5L0BA 1HDHA 3UN5A 2W5RA 3NKRA 4B56A 3NKOA 1EI6A 4ZGAA 5DLVA 3LXQA 4LR9A 4MHXA 3B5QA 1EJJA 2X98A 1N2LA 3WAWA 3WAXA 3BDFA 3IDDA 3UO0A 2ZKTA 2XRGA 4KAYA 5L0KA 1EW2A 1K7HA 3IGYB 1O98A 4UPLA 1E2SP 4LRFA 5TJ3A 4NWJA 1ALIA 4ZG7A 5C66A 1URAA 1ELZA 2GSNA 2IUCA 1KH7A 2XR9A 4ZG9A 4GTYA 4LR8A 2GA3A 4GTZA 1ALHA 1SHQA 4LRCA 2W5VA 3WBHA 3Q3QA 1ANIA 1EW9A 1AUKA 3NVLA 2W8SA 2RH6A 3TG0A 1KH5A 1P49A 4FDJA 1AJCA 3T01A 4KM4A 5DLWA 2ANHA 4LRDA 1ZEDA 1KH9A 3OT9A 4UPKA 4CXSA 3DYCA 1ZEFA 5L0EA 1AJBA 1ED8A 1AJAA 1E33P 5LIAA 4UOOA 4FDIA 4LR7A 4QAXA 5LQQA 1EQJA 1SHNA 1Y6VA 1ELXA 5IJQA 3UN3A 1KHKA 5HRTA 4ZG6A 2W8DA 1ANJA 4N7TA 1ALKA 4KJDA 1ED9A 1ZEBA 3CMRA 4NWXA 4UOPA 5K4PA 2G9YA 3E2DA 5INHA 5DLTA 3A52A 3M8YA 4MIVA 2VQRA 3M8ZA 3KD8A 4CYRA 3BDGB 4LQYA 2GLQA 3UN2A 3T02A 3WAYA 3NKPA 4CXUA 1FSUA 1E1ZP 1EW8A 1N2KA 1O99A 3M8WA 2W5XA 1HJKA 5KXAA 1KHJA 3ED4A 3NKQA 1Y7AA 3UNYA 1B8JA
chains in the Genus database with same CATH superfamily
3BDHA 5AJ9A 1ALJA 5EGHA 4KJGA 4LREA 1KHNA 1HQAA 4LR2A 3M7VA 4LRAA 1URBA 4UPIA 2QZUA 4MY4A 3TWZA 4UORA 4LRBA 2GSUA 5EGEA 3NKMA 4TN0A 3MK1A 3MK2A 2IFYA 3SZYA 3MK0A 4UPHA 3WAVA 1KHLA 1KH4A 3BDGA 3TX0A 5GRRA 2W5QA 2W5SA 4YR1A 1E3CP 4CXKA 1ELYA 2W5WA 4GTXA 3DPCA 3NKNA 4CYSA 5LRMA 3SZZA 2D1GA 4GTWA 3T00A 5LRNA 1AJDA 3IGZB 5IJSA 2IUCB 4KAVA 2W5TA 2GSOA 5GOVA 5L0BA 1HDHA 3UN5A 2W5RA 3NKRA 4B56A 3NKOA 1EI6A 4ZGAA 5DLVA 3LXQA 4LR9A 4MHXA 3B5QA 1EJJA 2X98A 1N2LA 3WAWA 3WAXA 3BDFA 3IDDA 3UO0A 2ZKTA 2XRGA 4KAYA 5L0KA 1EW2A 1K7HA 3IGYB 1O98A 4UPLA 1E2SP 4LRFA 5TJ3A 4NWJA 1ALIA 4ZG7A 5C66A 1URAA 1ELZA 2GSNA 2IUCA 1KH7A 2XR9A 4ZG9A 4GTYA 4LR8A 2GA3A 4GTZA 1ALHA 1SHQA 4LRCA 2W5VA 3WBHA 3Q3QA 1ANIA 1EW9A 1AUKA 3NVLA 2W8SA 2RH6A 3TG0A 1KH5A 1P49A 4FDJA 1AJCA 3T01A 4KM4A 5DLWA 2ANHA 4LRDA 1ZEDA 1KH9A 3OT9A 4UPKA 4CXSA 3DYCA 1ZEFA 5L0EA 1AJBA 1ED8A 1AJAA 1E33P 5LIAA 4UOOA 4FDIA 4LR7A 4QAXA 5LQQA 1EQJA 1SHNA 1Y6VA 1ELXA 5IJQA 3UN3A 1KHKA 5HRTA 4ZG6A 2W8DA 1ANJA 4N7TA 1ALKA 4KJDA 1ED9A 1ZEBA 3CMRA 4NWXA 4UOPA 5K4PA 2G9YA 3E2DA 5INHA 5DLTA 3A52A 3M8YA 4MIVA 2VQRA 3M8ZA 3KD8A 4CYRA 3BDGB 4LQYA 2GLQA 3UN2A 3T02A 3WAYA 3NKPA 4CXUA 1FSUA 1E1ZP 1EW8A 1N2KA 1O99A 3M8WA 2W5XA 1HJKA 5KXAA 1KHJA 3ED4A 3NKQA 1Y7AA 3UNYA 1B8JA
chains in the Genus database with same CATH topology
3BDHA 5AJ9A 1ALJA 5EGHA 4KJGA 4LREA 1KHNA 1HQAA 4LR2A 3M7VA 4LRAA 1URBA 4UPIA 2QZUA 4MY4A 3TWZA 4UORA 4LRBA 2GSUA 5EGEA 3NKMA 4TN0A 3MK1A 3MK2A 2IFYA 3SZYA 3MK0A 4UPHA 3WAVA 1KHLA 1KH4A 3BDGA 3TX0A 5GRRA 2W5QA 2W5SA 4YR1A 1E3CP 4CXKA 1ELYA 2W5WA 4GTXA 3DPCA 3NKNA 4CYSA 5LRMA 3SZZA 2D1GA 4GTWA 3T00A 5LRNA 1AJDA 3IGZB 5IJSA 2IUCB 4KAVA 2W5TA 2GSOA 5GOVA 5L0BA 1HDHA 3UN5A 2W5RA 3NKRA 4B56A 3NKOA 1EI6A 4ZGAA 5DLVA 3LXQA 4LR9A 4MHXA 3B5QA 1EJJA 2X98A 1N2LA 3WAWA 3WAXA 3BDFA 3IDDA 3UO0A 2ZKTA 2XRGA 4KAYA 5L0KA 1EW2A 1K7HA 3IGYB 1O98A 4UPLA 1E2SP 4LRFA 5TJ3A 4NWJA 1ALIA 4ZG7A 5C66A 1URAA 1ELZA 2GSNA 2IUCA 1KH7A 2XR9A 4ZG9A 4GTYA 4LR8A 2GA3A 4GTZA 1ALHA 1SHQA 4LRCA 2W5VA 3WBHA 3Q3QA 1ANIA 1EW9A 1AUKA 3NVLA 2W8SA 2RH6A 3TG0A 1KH5A 1P49A 4FDJA 1AJCA 3T01A 4KM4A 5DLWA 2ANHA 4LRDA 1ZEDA 1KH9A 3OT9A 4UPKA 4CXSA 3DYCA 1ZEFA 5L0EA 1AJBA 1ED8A 1AJAA 1E33P 5LIAA 4UOOA 4FDIA 4LR7A 4QAXA 5LQQA 1EQJA 1SHNA 1Y6VA 1ELXA 5IJQA 3UN3A 1KHKA 5HRTA 4ZG6A 2W8DA 1ANJA 4N7TA 1ALKA 4KJDA 1ED9A 1ZEBA 3CMRA 4NWXA 4UOPA 5K4PA 2G9YA 3E2DA 5INHA 5DLTA 3A52A 3M8YA 4MIVA 2VQRA 3M8ZA 3KD8A 4CYRA 3BDGB 4LQYA 2GLQA 3UN2A 3T02A 3WAYA 3NKPA 4CXUA 1FSUA 1E1ZP 1EW8A 1N2KA 1O99A 3M8WA 2W5XA 1HJKA 5KXAA 1KHJA 3ED4A 3NKQA 1Y7AA 3UNYA 1B8JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDH A;  5AJ9 A;  1ALJ A;  5EGH A;  4KJG A;  4LRE A;  1KHN A;  1HQA A;  4LR2 A;  3M7V A;  4LRA A;  1URB A;  4UPI A;  2QZU A;  4MY4 A;  3TWZ A;  4UOR A;  4LRB A;  2GSU A;  5EGE A;  3NKM A;  4TN0 A;  3MK1 A;  3MK2 A;  2IFY A;  3SZY A;  3MK0 A;  4UPH A;  3WAV A;  1KHL A;  1KH4 A;  3BDG A;  3TX0 A;  5GRR A;  2W5Q A;  2W5S A;  4YR1 A;  1E3C P;  4CXK A;  1ELY A;  2W5W A;  4GTX A;  3DPC A;  3NKN A;  4CYS A;  5LRM A;  3SZZ A;  2D1G A;  4GTW A;  3T00 A;  5LRN A;  1AJD A;  3IGZ B;  5IJS A;  2IUC B;  4KAV A;  2W5T A;  2GSO A;  5GOV A;  5L0B A;  1HDH A;  3UN5 A;  2W5R A;  3NKR A;  4B56 A;  3NKO A;  1EI6 A;  4ZGA A;  5DLV A;  3LXQ A;  4LR9 A;  4MHX A;  3B5Q A;  1EJJ A;  2X98 A;  1N2L A;  3WAW A;  3WAX A;  3BDF A;  3IDD A;  3UO0 A;  2ZKT A;  2XRG A;  4KAY A;  5L0K A;  1EW2 A;  1K7H A;  3IGY B;  1O98 A;  4UPL A;  1E2S P;  4LRF A;  5TJ3 A;  4NWJ A;  1ALI A;  4ZG7 A;  5C66 A;  1URA A;  1ELZ A;  2GSN A;  2IUC A;  1KH7 A;  2XR9 A;  4ZG9 A;  4GTY A;  4LR8 A;  2GA3 A;  4GTZ A;  1ALH A;  1SHQ A;  4LRC A;  2W5V A;  3WBH A;  3Q3Q A;  1ANI A;  1EW9 A;  1AUK A;  3NVL A;  2W8S A;  2RH6 A;  3TG0 A;  1KH5 A;  1P49 A;  4FDJ A;  1AJC A;  3T01 A;  4KM4 A;  5DLW A;  2ANH A;  4LRD A;  1ZED A;  1KH9 A;  3OT9 A;  4UPK A;  4CXS A;  3DYC A;  1ZEF A;  5L0E A;  1AJB A;  1ED8 A;  1AJA A;  1E33 P;  5LIA A;  4UOO A;  4FDI A;  4LR7 A;  4QAX A;  5LQQ A;  1EQJ A;  1SHN A;  1Y6V A;  1ELX A;  5IJQ A;  3UN3 A;  1KHK A;  5HRT A;  4ZG6 A;  2W8D A;  1ANJ A;  4N7T A;  1ALK A;  4KJD A;  1ED9 A;  1ZEB A;  3CMR A;  4NWX A;  4UOP A;  5K4P A;  2G9Y A;  3E2D A;  5INH A;  5DLT A;  3A52 A;  3M8Y A;  4MIV A;  2VQR A;  3M8Z A;  3KD8 A;  4CYR A;  3BDG B;  4LQY A;  2GLQ A;  3UN2 A;  3T02 A;  3WAY A;  3NKP A;  4CXU A;  1FSU A;  1E1Z P;  1EW8 A;  1N2K A;  1O99 A;  3M8W A;  2W5X A;  1HJK A;  5KXA A;  1KHJ A;  3ED4 A;  3NKQ A;  1Y7A A;  3UNY A;  1B8J A; 
#chains in the Genus database with same CATH topology
 3BDH A;  5AJ9 A;  1ALJ A;  5EGH A;  4KJG A;  4LRE A;  1KHN A;  1HQA A;  4LR2 A;  3M7V A;  4LRA A;  1URB A;  4UPI A;  2QZU A;  4MY4 A;  3TWZ A;  4UOR A;  4LRB A;  2GSU A;  5EGE A;  3NKM A;  4TN0 A;  3MK1 A;  3MK2 A;  2IFY A;  3SZY A;  3MK0 A;  4UPH A;  3WAV A;  1KHL A;  1KH4 A;  3BDG A;  3TX0 A;  5GRR A;  2W5Q A;  2W5S A;  4YR1 A;  1E3C P;  4CXK A;  1ELY A;  2W5W A;  4GTX A;  3DPC A;  3NKN A;  4CYS A;  5LRM A;  3SZZ A;  2D1G A;  4GTW A;  3T00 A;  5LRN A;  1AJD A;  3IGZ B;  5IJS A;  2IUC B;  4KAV A;  2W5T A;  2GSO A;  5GOV A;  5L0B A;  1HDH A;  3UN5 A;  2W5R A;  3NKR A;  4B56 A;  3NKO A;  1EI6 A;  4ZGA A;  5DLV A;  3LXQ A;  4LR9 A;  4MHX A;  3B5Q A;  1EJJ A;  2X98 A;  1N2L A;  3WAW A;  3WAX A;  3BDF A;  3IDD A;  3UO0 A;  2ZKT A;  2XRG A;  4KAY A;  5L0K A;  1EW2 A;  1K7H A;  3IGY B;  1O98 A;  4UPL A;  1E2S P;  4LRF A;  5TJ3 A;  4NWJ A;  1ALI A;  4ZG7 A;  5C66 A;  1URA A;  1ELZ A;  2GSN A;  2IUC A;  1KH7 A;  2XR9 A;  4ZG9 A;  4GTY A;  4LR8 A;  2GA3 A;  4GTZ A;  1ALH A;  1SHQ A;  4LRC A;  2W5V A;  3WBH A;  3Q3Q A;  1ANI A;  1EW9 A;  1AUK A;  3NVL A;  2W8S A;  2RH6 A;  3TG0 A;  1KH5 A;  1P49 A;  4FDJ A;  1AJC A;  3T01 A;  4KM4 A;  5DLW A;  2ANH A;  4LRD A;  1ZED A;  1KH9 A;  3OT9 A;  4UPK A;  4CXS A;  3DYC A;  1ZEF A;  5L0E A;  1AJB A;  1ED8 A;  1AJA A;  1E33 P;  5LIA A;  4UOO A;  4FDI A;  4LR7 A;  4QAX A;  5LQQ A;  1EQJ A;  1SHN A;  1Y6V A;  1ELX A;  5IJQ A;  3UN3 A;  1KHK A;  5HRT A;  4ZG6 A;  2W8D A;  1ANJ A;  4N7T A;  1ALK A;  4KJD A;  1ED9 A;  1ZEB A;  3CMR A;  4NWX A;  4UOP A;  5K4P A;  2G9Y A;  3E2D A;  5INH A;  5DLT A;  3A52 A;  3M8Y A;  4MIV A;  2VQR A;  3M8Z A;  3KD8 A;  4CYR A;  3BDG B;  4LQY A;  2GLQ A;  3UN2 A;  3T02 A;  3WAY A;  3NKP A;  4CXU A;  1FSU A;  1E1Z P;  1EW8 A;  1N2K A;  1O99 A;  3M8W A;  2W5X A;  1HJK A;  5KXA A;  1KHJ A;  3ED4 A;  3NKQ A;  1Y7A A;  3UNY A;  1B8J A; 
#chains in the Genus database with same CATH homology
 3BDH A;  5AJ9 A;  1ALJ A;  5EGH A;  4KJG A;  4LRE A;  1KHN A;  1HQA A;  4LR2 A;  3M7V A;  4LRA A;  1URB A;  4UPI A;  2QZU A;  4MY4 A;  3TWZ A;  4UOR A;  4LRB A;  2GSU A;  5EGE A;  3NKM A;  4TN0 A;  3MK1 A;  3MK2 A;  2IFY A;  3SZY A;  3MK0 A;  4UPH A;  3WAV A;  1KHL A;  1KH4 A;  3BDG A;  3TX0 A;  5GRR A;  2W5Q A;  2W5S A;  4YR1 A;  1E3C P;  4CXK A;  1ELY A;  2W5W A;  4GTX A;  3DPC A;  3NKN A;  4CYS A;  5LRM A;  3SZZ A;  2D1G A;  4GTW A;  3T00 A;  5LRN A;  1AJD A;  3IGZ B;  5IJS A;  2IUC B;  4KAV A;  2W5T A;  2GSO A;  5GOV A;  5L0B A;  1HDH A;  3UN5 A;  2W5R A;  3NKR A;  4B56 A;  3NKO A;  1EI6 A;  4ZGA A;  5DLV A;  3LXQ A;  4LR9 A;  4MHX A;  3B5Q A;  1EJJ A;  2X98 A;  1N2L A;  3WAW A;  3WAX A;  3BDF A;  3IDD A;  3UO0 A;  2ZKT A;  2XRG A;  4KAY A;  5L0K A;  1EW2 A;  1K7H A;  3IGY B;  1O98 A;  4UPL A;  1E2S P;  4LRF A;  5TJ3 A;  4NWJ A;  1ALI A;  4ZG7 A;  5C66 A;  1URA A;  1ELZ A;  2GSN A;  2IUC A;  1KH7 A;  2XR9 A;  4ZG9 A;  4GTY A;  4LR8 A;  2GA3 A;  4GTZ A;  1ALH A;  1SHQ A;  4LRC A;  2W5V A;  3WBH A;  3Q3Q A;  1ANI A;  1EW9 A;  1AUK A;  3NVL A;  2W8S A;  2RH6 A;  3TG0 A;  1KH5 A;  1P49 A;  4FDJ A;  1AJC A;  3T01 A;  4KM4 A;  5DLW A;  2ANH A;  4LRD A;  1ZED A;  1KH9 A;  3OT9 A;  4UPK A;  4CXS A;  3DYC A;  1ZEF A;  5L0E A;  1AJB A;  1ED8 A;  1AJA A;  1E33 P;  5LIA A;  4UOO A;  4FDI A;  4LR7 A;  4QAX A;  5LQQ A;  1EQJ A;  1SHN A;  1Y6V A;  1ELX A;  5IJQ A;  3UN3 A;  1KHK A;  5HRT A;  4ZG6 A;  2W8D A;  1ANJ A;  4N7T A;  1ALK A;  4KJD A;  1ED9 A;  1ZEB A;  3CMR A;  4NWX A;  4UOP A;  5K4P A;  2G9Y A;  3E2D A;  5INH A;  5DLT A;  3A52 A;  3M8Y A;  4MIV A;  2VQR A;  3M8Z A;  3KD8 A;  4CYR A;  3BDG B;  4LQY A;  2GLQ A;  3UN2 A;  3T02 A;  3WAY A;  3NKP A;  4CXU A;  1FSU A;  1E1Z P;  1EW8 A;  1N2K A;  1O99 A;  3M8W A;  2W5X A;  1HJK A;  5KXA A;  1KHJ A;  3ED4 A;  3NKQ A;  1Y7A A;  3UNY A;  1B8J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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