3IGYB

Crystal structures of leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Total Genus 205
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
205
Knots found
sequence length
549
structure length
549
Chain Sequence
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRHFRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGEIYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDGAKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRMFVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQYYPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACSETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITEAAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDAVDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Isomerase
molecule keywords Cofactor-independent phosphoglycerate mutase
publication title Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
pubmed doi rcsb
source organism Leishmania mexicana
total genus 205
structure length 549
sequence length 549
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.1: Transferred entry: 5.4.2.11 and 5.4.2.12.
pdb deposition date 2009-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01676 Metalloenzyme Metalloenzyme superfamily
B PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3igyB01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 3igyB02
4LRFA 3BDHA 3NKQA 2W5VA 4UPKA 4CXKA 1E3CP 5IJQA 2W8SA 1ZEDA 3NKRA 1ANJA 3NKPA 1AJDA 2ANHA 4UOOA 1ALHA 2GLQA 5L0EA 1ANIA 5LIAA 1EW2A 1URBA 4LR7A 1SHNA 4ZG9A 5GRRA 1ELZA 4FDIA 1AJCA 4LRDA 3NKOA 1KHJA 1AJAA 1N2LA 3Q3QA 4LRCA 4N7TA 3BDGA 3WBHA 3TG0A 3M8YA 4KJGA 1EW9A 4UORA 1ZEBA 3BDFA 1ELXA 3SZYA 1KHKA 1SHQA 1EQJA 4MHXA 5LRMA 2RH6A 4CYSA 1KHLA 1KH4A 1ALIA 3MK2A 2W5SA 1KH9A 5KXAA 4LR2A 2W8DA 5TJ3A 5C66A 1URAA 2GSOA 3NKMA 3A52A 4UOPA 4UPHA 5DLTA 5L0BA 4LR8A 4KM4A 3ED4A 2W5WA 2W5XA 3M8WA 3TWZA 4B56A 4UPIA 3TX0A 3OT9A 3DPCA 3M7VA 4LREA 2XR9A 1AJBA 1ALJA 3IGYB 4LRBA 1O99A 3B5QA 3IGZB 4GTWA 4NWJA 2XRGA 4KJDA 4LR9A 2VQRA 1O98A 2IFYA 3UO0A 3T00A 2W5QA 3UN3A 4ZG7A 1ED9A 1KHNA 1HDHA 1EJJA 1P49A 4ZG6A 3E2DA 2IUCB 5GOVA 1HQAA 4CXUA 2QZUA 4UPLA 3LXQA 4MY4A 3SZZA 5L0KA 2W5RA 4GTXA 3M8ZA 4GTYA 1FSUA 1KH7A 3UN5A 3UNYA 4ZGAA 3MK0A 4CXSA 5DLWA 4KAYA 1EI6A 1ZEFA 3WAYA 1E1ZP 4NWXA 1ELYA 1K7HA 1AUKA 3DYCA 5IJSA 3MK1A 1B8JA 2W5TA 3T01A 5DLVA 5LQQA 4LRAA 2ZKTA 3BDGB 3UN2A 5LRNA 1Y7AA 3T02A 4KAVA 5EGEA 3WAXA 1N2KA 4GTZA 1EW8A 2D1GA 5K4PA 4LQYA 4TN0A 3KD8A 2G9YA 1ALKA 3NKNA 1HJKA 1KH5A 4YR1A 3CMRA 2IUCA 5AJ9A 5INHA 2GSNA 1E2SP 4MIVA 5EGHA 3WAWA 1ED8A 1Y6VA 4CYRA 2GA3A 3IDDA 1E33P 2GSUA 5HRTA 4QAXA 4FDJA 2X98A 3NVLA 3WAVA
chains in the Genus database with same CATH superfamily
4LRFA 3BDHA 3NKQA 2W5VA 4UPKA 4CXKA 1E3CP 5IJQA 2W8SA 1ZEDA 3NKRA 1ANJA 3NKPA 1AJDA 2ANHA 4UOOA 1ALHA 2GLQA 5L0EA 1ANIA 5LIAA 1EW2A 1URBA 4LR7A 1SHNA 4ZG9A 5GRRA 1ELZA 4FDIA 1AJCA 4LRDA 3NKOA 1KHJA 1AJAA 1N2LA 3Q3QA 4LRCA 4N7TA 3BDGA 3WBHA 3TG0A 3M8YA 4KJGA 1EW9A 4UORA 1ZEBA 3BDFA 1ELXA 3SZYA 1KHKA 1SHQA 1EQJA 4MHXA 5LRMA 2RH6A 4CYSA 1KHLA 1KH4A 1ALIA 3MK2A 2W5SA 1KH9A 5KXAA 4LR2A 2W8DA 5TJ3A 5C66A 1URAA 2GSOA 3NKMA 3A52A 4UOPA 4UPHA 5DLTA 5L0BA 4LR8A 4KM4A 3ED4A 2W5WA 2W5XA 3M8WA 3TWZA 4B56A 4UPIA 3TX0A 3OT9A 3DPCA 3M7VA 4LREA 2XR9A 1AJBA 1ALJA 3IGYB 4LRBA 1O99A 3B5QA 3IGZB 4GTWA 4NWJA 2XRGA 4KJDA 4LR9A 2VQRA 1O98A 2IFYA 3UO0A 3T00A 2W5QA 3UN3A 4ZG7A 1ED9A 1KHNA 1HDHA 1EJJA 1P49A 4ZG6A 3E2DA 2IUCB 5GOVA 1HQAA 4CXUA 2QZUA 4UPLA 3LXQA 4MY4A 3SZZA 5L0KA 2W5RA 4GTXA 3M8ZA 4GTYA 1FSUA 1KH7A 3UN5A 3UNYA 4ZGAA 3MK0A 4CXSA 5DLWA 4KAYA 1EI6A 1ZEFA 3WAYA 1E1ZP 4NWXA 1ELYA 1K7HA 1AUKA 3DYCA 5IJSA 3MK1A 1B8JA 2W5TA 3T01A 5DLVA 5LQQA 4LRAA 2ZKTA 3BDGB 3UN2A 5LRNA 1Y7AA 3T02A 4KAVA 5EGEA 3WAXA 1N2KA 4GTZA 1EW8A 2D1GA 5K4PA 4LQYA 4TN0A 3KD8A 2G9YA 1ALKA 3NKNA 1HJKA 1KH5A 4YR1A 3CMRA 2IUCA 5AJ9A 5INHA 2GSNA 1E2SP 4MIVA 5EGHA 3WAWA 1ED8A 1Y6VA 4CYRA 2GA3A 3IDDA 1E33P 2GSUA 5HRTA 4QAXA 4FDJA 2X98A 3NVLA 3WAVA
chains in the Genus database with same CATH topology
4LRFA 3BDHA 3NKQA 2W5VA 4UPKA 4CXKA 1E3CP 5IJQA 2W8SA 1ZEDA 3NKRA 1ANJA 3NKPA 1AJDA 2ANHA 4UOOA 1ALHA 2GLQA 5L0EA 1ANIA 5LIAA 1EW2A 1URBA 4LR7A 1SHNA 4ZG9A 5GRRA 1ELZA 4FDIA 1AJCA 4LRDA 3NKOA 1KHJA 1AJAA 1N2LA 3Q3QA 4LRCA 4N7TA 3BDGA 3WBHA 3TG0A 3M8YA 4KJGA 1EW9A 4UORA 1ZEBA 3BDFA 1ELXA 3SZYA 1KHKA 1SHQA 1EQJA 4MHXA 5LRMA 2RH6A 4CYSA 1KHLA 1KH4A 1ALIA 3MK2A 2W5SA 1KH9A 5KXAA 4LR2A 2W8DA 5TJ3A 5C66A 1URAA 2GSOA 3NKMA 3A52A 4UOPA 4UPHA 5DLTA 5L0BA 4LR8A 4KM4A 3ED4A 2W5WA 2W5XA 3M8WA 3TWZA 4B56A 4UPIA 3TX0A 3OT9A 3DPCA 3M7VA 4LREA 2XR9A 1AJBA 1ALJA 3IGYB 4LRBA 1O99A 3B5QA 3IGZB 4GTWA 4NWJA 2XRGA 4KJDA 4LR9A 2VQRA 1O98A 2IFYA 3UO0A 3T00A 2W5QA 3UN3A 4ZG7A 1ED9A 1KHNA 1HDHA 1EJJA 1P49A 4ZG6A 3E2DA 2IUCB 5GOVA 1HQAA 4CXUA 2QZUA 4UPLA 3LXQA 4MY4A 3SZZA 5L0KA 2W5RA 4GTXA 3M8ZA 4GTYA 1FSUA 1KH7A 3UN5A 3UNYA 4ZGAA 3MK0A 4CXSA 5DLWA 4KAYA 1EI6A 1ZEFA 3WAYA 1E1ZP 4NWXA 1ELYA 1K7HA 1AUKA 3DYCA 5IJSA 3MK1A 1B8JA 2W5TA 3T01A 5DLVA 5LQQA 4LRAA 2ZKTA 3BDGB 3UN2A 5LRNA 1Y7AA 3T02A 4KAVA 5EGEA 3WAXA 1N2KA 4GTZA 1EW8A 2D1GA 5K4PA 4LQYA 4TN0A 3KD8A 2G9YA 1ALKA 3NKNA 1HJKA 1KH5A 4YR1A 3CMRA 2IUCA 5AJ9A 5INHA 2GSNA 1E2SP 4MIVA 5EGHA 3WAWA 1ED8A 1Y6VA 4CYRA 2GA3A 3IDDA 1E33P 2GSUA 5HRTA 4QAXA 4FDJA 2X98A 3NVLA 3WAVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRF A;  3BDH A;  3NKQ A;  2W5V A;  4UPK A;  4CXK A;  1E3C P;  5IJQ A;  2W8S A;  1ZED A;  3NKR A;  1ANJ A;  3NKP A;  1AJD A;  2ANH A;  4UOO A;  1ALH A;  2GLQ A;  5L0E A;  1ANI A;  5LIA A;  1EW2 A;  1URB A;  4LR7 A;  1SHN A;  4ZG9 A;  5GRR A;  1ELZ A;  4FDI A;  1AJC A;  4LRD A;  3NKO A;  1KHJ A;  1AJA A;  1N2L A;  3Q3Q A;  4LRC A;  4N7T A;  3BDG A;  3WBH A;  3TG0 A;  3M8Y A;  4KJG A;  1EW9 A;  4UOR A;  1ZEB A;  3BDF A;  1ELX A;  3SZY A;  1KHK A;  1SHQ A;  1EQJ A;  4MHX A;  5LRM A;  2RH6 A;  4CYS A;  1KHL A;  1KH4 A;  1ALI A;  3MK2 A;  2W5S A;  1KH9 A;  5KXA A;  4LR2 A;  2W8D A;  5TJ3 A;  5C66 A;  1URA A;  2GSO A;  3NKM A;  3A52 A;  4UOP A;  4UPH A;  5DLT A;  5L0B A;  4LR8 A;  4KM4 A;  3ED4 A;  2W5W A;  2W5X A;  3M8W A;  3TWZ A;  4B56 A;  4UPI A;  3TX0 A;  3OT9 A;  3DPC A;  3M7V A;  4LRE A;  2XR9 A;  1AJB A;  1ALJ A;  3IGY B;  4LRB A;  1O99 A;  3B5Q A;  3IGZ B;  4GTW A;  4NWJ A;  2XRG A;  4KJD A;  4LR9 A;  2VQR A;  1O98 A;  2IFY A;  3UO0 A;  3T00 A;  2W5Q A;  3UN3 A;  4ZG7 A;  1ED9 A;  1KHN A;  1HDH A;  1EJJ A;  1P49 A;  4ZG6 A;  3E2D A;  2IUC B;  5GOV A;  1HQA A;  4CXU A;  2QZU A;  4UPL A;  3LXQ A;  4MY4 A;  3SZZ A;  5L0K A;  2W5R A;  4GTX A;  3M8Z A;  4GTY A;  1FSU A;  1KH7 A;  3UN5 A;  3UNY A;  4ZGA A;  3MK0 A;  4CXS A;  5DLW A;  4KAY A;  1EI6 A;  1ZEF A;  3WAY A;  1E1Z P;  4NWX A;  1ELY A;  1K7H A;  1AUK A;  3DYC A;  5IJS A;  3MK1 A;  1B8J A;  2W5T A;  3T01 A;  5DLV A;  5LQQ A;  4LRA A;  2ZKT A;  3BDG B;  3UN2 A;  5LRN A;  1Y7A A;  3T02 A;  4KAV A;  5EGE A;  3WAX A;  1N2K A;  4GTZ A;  1EW8 A;  2D1G A;  5K4P A;  4LQY A;  4TN0 A;  3KD8 A;  2G9Y A;  1ALK A;  3NKN A;  1HJK A;  1KH5 A;  4YR1 A;  3CMR A;  2IUC A;  5AJ9 A;  5INH A;  2GSN A;  1E2S P;  4MIV A;  5EGH A;  3WAW A;  1ED8 A;  1Y6V A;  4CYR A;  2GA3 A;  3IDD A;  1E33 P;  2GSU A;  5HRT A;  4QAX A;  4FDJ A;  2X98 A;  3NVL A;  3WAV A; 
#chains in the Genus database with same CATH topology
 4LRF A;  3BDH A;  3NKQ A;  2W5V A;  4UPK A;  4CXK A;  1E3C P;  5IJQ A;  2W8S A;  1ZED A;  3NKR A;  1ANJ A;  3NKP A;  1AJD A;  2ANH A;  4UOO A;  1ALH A;  2GLQ A;  5L0E A;  1ANI A;  5LIA A;  1EW2 A;  1URB A;  4LR7 A;  1SHN A;  4ZG9 A;  5GRR A;  1ELZ A;  4FDI A;  1AJC A;  4LRD A;  3NKO A;  1KHJ A;  1AJA A;  1N2L A;  3Q3Q A;  4LRC A;  4N7T A;  3BDG A;  3WBH A;  3TG0 A;  3M8Y A;  4KJG A;  1EW9 A;  4UOR A;  1ZEB A;  3BDF A;  1ELX A;  3SZY A;  1KHK A;  1SHQ A;  1EQJ A;  4MHX A;  5LRM A;  2RH6 A;  4CYS A;  1KHL A;  1KH4 A;  1ALI A;  3MK2 A;  2W5S A;  1KH9 A;  5KXA A;  4LR2 A;  2W8D A;  5TJ3 A;  5C66 A;  1URA A;  2GSO A;  3NKM A;  3A52 A;  4UOP A;  4UPH A;  5DLT A;  5L0B A;  4LR8 A;  4KM4 A;  3ED4 A;  2W5W A;  2W5X A;  3M8W A;  3TWZ A;  4B56 A;  4UPI A;  3TX0 A;  3OT9 A;  3DPC A;  3M7V A;  4LRE A;  2XR9 A;  1AJB A;  1ALJ A;  3IGY B;  4LRB A;  1O99 A;  3B5Q A;  3IGZ B;  4GTW A;  4NWJ A;  2XRG A;  4KJD A;  4LR9 A;  2VQR A;  1O98 A;  2IFY A;  3UO0 A;  3T00 A;  2W5Q A;  3UN3 A;  4ZG7 A;  1ED9 A;  1KHN A;  1HDH A;  1EJJ A;  1P49 A;  4ZG6 A;  3E2D A;  2IUC B;  5GOV A;  1HQA A;  4CXU A;  2QZU A;  4UPL A;  3LXQ A;  4MY4 A;  3SZZ A;  5L0K A;  2W5R A;  4GTX A;  3M8Z A;  4GTY A;  1FSU A;  1KH7 A;  3UN5 A;  3UNY A;  4ZGA A;  3MK0 A;  4CXS A;  5DLW A;  4KAY A;  1EI6 A;  1ZEF A;  3WAY A;  1E1Z P;  4NWX A;  1ELY A;  1K7H A;  1AUK A;  3DYC A;  5IJS A;  3MK1 A;  1B8J A;  2W5T A;  3T01 A;  5DLV A;  5LQQ A;  4LRA A;  2ZKT A;  3BDG B;  3UN2 A;  5LRN A;  1Y7A A;  3T02 A;  4KAV A;  5EGE A;  3WAX A;  1N2K A;  4GTZ A;  1EW8 A;  2D1G A;  5K4P A;  4LQY A;  4TN0 A;  3KD8 A;  2G9Y A;  1ALK A;  3NKN A;  1HJK A;  1KH5 A;  4YR1 A;  3CMR A;  2IUC A;  5AJ9 A;  5INH A;  2GSN A;  1E2S P;  4MIV A;  5EGH A;  3WAW A;  1ED8 A;  1Y6V A;  4CYR A;  2GA3 A;  3IDD A;  1E33 P;  2GSU A;  5HRT A;  4QAX A;  4FDJ A;  2X98 A;  3NVL A;  3WAV A; 
#chains in the Genus database with same CATH homology
 4LRF A;  3BDH A;  3NKQ A;  2W5V A;  4UPK A;  4CXK A;  1E3C P;  5IJQ A;  2W8S A;  1ZED A;  3NKR A;  1ANJ A;  3NKP A;  1AJD A;  2ANH A;  4UOO A;  1ALH A;  2GLQ A;  5L0E A;  1ANI A;  5LIA A;  1EW2 A;  1URB A;  4LR7 A;  1SHN A;  4ZG9 A;  5GRR A;  1ELZ A;  4FDI A;  1AJC A;  4LRD A;  3NKO A;  1KHJ A;  1AJA A;  1N2L A;  3Q3Q A;  4LRC A;  4N7T A;  3BDG A;  3WBH A;  3TG0 A;  3M8Y A;  4KJG A;  1EW9 A;  4UOR A;  1ZEB A;  3BDF A;  1ELX A;  3SZY A;  1KHK A;  1SHQ A;  1EQJ A;  4MHX A;  5LRM A;  2RH6 A;  4CYS A;  1KHL A;  1KH4 A;  1ALI A;  3MK2 A;  2W5S A;  1KH9 A;  5KXA A;  4LR2 A;  2W8D A;  5TJ3 A;  5C66 A;  1URA A;  2GSO A;  3NKM A;  3A52 A;  4UOP A;  4UPH A;  5DLT A;  5L0B A;  4LR8 A;  4KM4 A;  3ED4 A;  2W5W A;  2W5X A;  3M8W A;  3TWZ A;  4B56 A;  4UPI A;  3TX0 A;  3OT9 A;  3DPC A;  3M7V A;  4LRE A;  2XR9 A;  1AJB A;  1ALJ A;  3IGY B;  4LRB A;  1O99 A;  3B5Q A;  3IGZ B;  4GTW A;  4NWJ A;  2XRG A;  4KJD A;  4LR9 A;  2VQR A;  1O98 A;  2IFY A;  3UO0 A;  3T00 A;  2W5Q A;  3UN3 A;  4ZG7 A;  1ED9 A;  1KHN A;  1HDH A;  1EJJ A;  1P49 A;  4ZG6 A;  3E2D A;  2IUC B;  5GOV A;  1HQA A;  4CXU A;  2QZU A;  4UPL A;  3LXQ A;  4MY4 A;  3SZZ A;  5L0K A;  2W5R A;  4GTX A;  3M8Z A;  4GTY A;  1FSU A;  1KH7 A;  3UN5 A;  3UNY A;  4ZGA A;  3MK0 A;  4CXS A;  5DLW A;  4KAY A;  1EI6 A;  1ZEF A;  3WAY A;  1E1Z P;  4NWX A;  1ELY A;  1K7H A;  1AUK A;  3DYC A;  5IJS A;  3MK1 A;  1B8J A;  2W5T A;  3T01 A;  5DLV A;  5LQQ A;  4LRA A;  2ZKT A;  3BDG B;  3UN2 A;  5LRN A;  1Y7A A;  3T02 A;  4KAV A;  5EGE A;  3WAX A;  1N2K A;  4GTZ A;  1EW8 A;  2D1G A;  5K4P A;  4LQY A;  4TN0 A;  3KD8 A;  2G9Y A;  1ALK A;  3NKN A;  1HJK A;  1KH5 A;  4YR1 A;  3CMR A;  2IUC A;  5AJ9 A;  5INH A;  2GSN A;  1E2S P;  4MIV A;  5EGH A;  3WAW A;  1ED8 A;  1Y6V A;  4CYR A;  2GA3 A;  3IDD A;  1E33 P;  2GSU A;  5HRT A;  4QAX A;  4FDJ A;  2X98 A;  3NVL A;  3WAV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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