3IGYB

Crystal structures of leishmania mexicana phosphoglycerate mutase at high cobalt concentrations
Total Genus 205
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
205
Knots found
sequence length
549
structure length
549
Chain Sequence
LLLKPHKDLPRRTVLIVVMDGLGIGPEDDYDAVHMASTPFMDAHRRDNRHFRCVRAHGTAVGLPTDADMGNSEVGHNALGAGRVALQGASLVDDAIKSGEIYTGEGYRYLHGAFSKEGSTLHLIGLLSDGGVHSRDNQIYSIIEHAVKDGAKRIRVHALYDGRDVPDGSSFRFTDELEAVLAKVRQNGCDAAIASGGGRMFVTMDRYDADWSIVERGWRAQVLGDARHFHSAKEAITTFREEDPKVTDQYYPPFIVVDEQDKPLGTIEDGDAVLCVNFRGDRVIEMTRAFEDEDFNKFDRVRVPKVRYAGMMRYDGDLGIPNNFLVPPPKLTRVSEEYLCGSGLNIFACSETQKFGHVTYFWNGNRSGKIDEKHETFKEVPSDRVQFNEKPRMQSAAITEAAIEALKSGMYNVVRINFPNGDMVGHTGDLKATITGVEAVDESLAKLKDAVDSVNGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTSHTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPEDYEPSLIYVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Cofactor-independent phosphoglycerate mutase
publication title Crystal structures of Leishmania mexicana phosphoglycerate mutase suggest a one-metal mechanism and a new enzyme subclass
pubmed doi rcsb
source organism Leishmania mexicana
molecule tags Isomerase
total genus 205
structure length 549
sequence length 549
other databases KnotProt 2.0: S +31
ec nomenclature ec 5.4.2.1: Transferred entry: 5.4.2.11 and 5.4.2.12.
pdb deposition date 2009-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF01676 Metalloenzyme Metalloenzyme superfamily
B PF06415 iPGM_N BPG-independent PGAM N-terminus (iPGM_N)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3igyB01
3.40.1450.10 Alpha Beta 3-Layer(aba) Sandwich 2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain BPG-independent phosphoglycerate mutase, domain B 3igyB02
2W8SA 5EGHA 5IJQA 4UPIA 4LRDA 1EQJA 5HRTA 1ELZA 4FDIA 4CXSA 5INHA 2GSUA 3BDHA 3MK1A 3WAXA 3MK0A 5DLVA 3WAYA 3SZZA 1ELYA 4LR8A 2XRGA 4GTXA 1ANJA 4MIVA 1ED8A 4LR2A 1ELXA 1Y6VA 3CMRA 2VQRA 4NWXA 4YR1A 5GOVA 1SHNA 4KJDA 3TX0A 1K7HA 5AJ9A 3A52A 5LRNA 1ALKA 1B8JA 3LXQA 1EI6A 4LREA 1AJCA 2W5TA 1EW2A 2W5SA 5LQQA 1O98A 3WBHA 2IUCA 4MHXA 1KHKA 5LRMA 4UOOA 1HJKA 5TJ3A 1KH4A 3NKOA 3B5QA 4UPKA 3SZYA 3UN3A 4ZG9A 2IUCB 1N2KA 3BDGB 4B56A 1EJJA 4LR7A 3KD8A 4CYRA 1KH9A 1ZEDA 3DPCA 5C66A 1N2LA 3NKPA 4LR9A 4UPLA 1E2SP 4CXKA 5L0EA 1ALJA 1AJBA 1E33P 1E3CP 2RH6A 4GTZA 5L0KA 4MY4A 3WAVA 1FSUA 3DYCA 4LQYA 2ANHA 2QZUA 1ED9A 4CYSA 1EW9A 1ZEBA 1ALHA 2ZKTA 3UO0A 4LRCA 4KAVA 4KM4A 3BDGA 2D1GA 3WAWA 1KHNA 2W5WA 2XR9A 4KJGA 2G9YA 3BDFA 5DLWA 3NKNA 1KH5A 1KHLA 5EGEA 4KAYA 2W5QA 3UNYA 2GA3A 5DLTA 3T01A 5K4PA 2IFYA 3M8ZA 1KHJA 3OT9A 4N7TA 4FDJA 3ED4A 1P49A 3UN5A 5IJSA 3NKMA 3M8WA 4QAXA 5L0BA 3MK2A 1AJAA 2W5RA 2GLQA 3NVLA 1AJDA 4UOPA 4ZG7A 4UPHA 4LRFA 3M8YA 3NKRA 2GSNA 3UN2A 1ALIA 1O99A 3IGZB 4UORA 3M7VA 1E1ZP 1HQAA 1ANIA 5GRRA 3E2DA 1URAA 3T02A 1Y7AA 4CXUA 4GTWA 4LRAA 4NWJA 1KH7A 2W5VA 2X98A 1SHQA 2W5XA 3IDDA 2GSOA 3IGYB 4LRBA 3TWZA 3TG0A 3T00A 1EW8A 5LIAA 1ZEFA 2W8DA 4GTYA 5KXAA 3Q3QA 3NKQA 1AUKA 4ZGAA 4ZG6A 4TN0A 1HDHA 1URBA
chains in the Genus database with same CATH superfamily
2W8SA 5EGHA 5IJQA 4UPIA 4LRDA 1EQJA 5HRTA 1ELZA 4FDIA 4CXSA 5INHA 2GSUA 3BDHA 3MK1A 3WAXA 3MK0A 5DLVA 3WAYA 3SZZA 1ELYA 4LR8A 2XRGA 4GTXA 1ANJA 4MIVA 1ED8A 4LR2A 1ELXA 1Y6VA 3CMRA 2VQRA 4NWXA 4YR1A 5GOVA 1SHNA 4KJDA 3TX0A 1K7HA 5AJ9A 3A52A 5LRNA 1ALKA 1B8JA 3LXQA 1EI6A 4LREA 1AJCA 2W5TA 1EW2A 2W5SA 5LQQA 1O98A 3WBHA 2IUCA 4MHXA 1KHKA 5LRMA 4UOOA 1HJKA 5TJ3A 1KH4A 3NKOA 3B5QA 4UPKA 3SZYA 3UN3A 4ZG9A 2IUCB 1N2KA 3BDGB 4B56A 1EJJA 4LR7A 3KD8A 4CYRA 1KH9A 1ZEDA 3DPCA 5C66A 1N2LA 3NKPA 4LR9A 4UPLA 1E2SP 4CXKA 5L0EA 1ALJA 1AJBA 1E33P 1E3CP 2RH6A 4GTZA 5L0KA 4MY4A 3WAVA 1FSUA 3DYCA 4LQYA 2ANHA 2QZUA 1ED9A 4CYSA 1EW9A 1ZEBA 1ALHA 2ZKTA 3UO0A 4LRCA 4KAVA 4KM4A 3BDGA 2D1GA 3WAWA 1KHNA 2W5WA 2XR9A 4KJGA 2G9YA 3BDFA 5DLWA 3NKNA 1KH5A 1KHLA 5EGEA 4KAYA 2W5QA 3UNYA 2GA3A 5DLTA 3T01A 5K4PA 2IFYA 3M8ZA 1KHJA 3OT9A 4N7TA 4FDJA 3ED4A 1P49A 3UN5A 5IJSA 3NKMA 3M8WA 4QAXA 5L0BA 3MK2A 1AJAA 2W5RA 2GLQA 3NVLA 1AJDA 4UOPA 4ZG7A 4UPHA 4LRFA 3M8YA 3NKRA 2GSNA 3UN2A 1ALIA 1O99A 3IGZB 4UORA 3M7VA 1E1ZP 1HQAA 1ANIA 5GRRA 3E2DA 1URAA 3T02A 1Y7AA 4CXUA 4GTWA 4LRAA 4NWJA 1KH7A 2W5VA 2X98A 1SHQA 2W5XA 3IDDA 2GSOA 3IGYB 4LRBA 3TWZA 3TG0A 3T00A 1EW8A 5LIAA 1ZEFA 2W8DA 4GTYA 5KXAA 3Q3QA 3NKQA 1AUKA 4ZGAA 4ZG6A 4TN0A 1HDHA 1URBA
chains in the Genus database with same CATH topology
2W8SA 5EGHA 5IJQA 4UPIA 4LRDA 1EQJA 5HRTA 1ELZA 4FDIA 4CXSA 5INHA 2GSUA 3BDHA 3MK1A 3WAXA 3MK0A 5DLVA 3WAYA 3SZZA 1ELYA 4LR8A 2XRGA 4GTXA 1ANJA 4MIVA 1ED8A 4LR2A 1ELXA 1Y6VA 3CMRA 2VQRA 4NWXA 4YR1A 5GOVA 1SHNA 4KJDA 3TX0A 1K7HA 5AJ9A 3A52A 5LRNA 1ALKA 1B8JA 3LXQA 1EI6A 4LREA 1AJCA 2W5TA 1EW2A 2W5SA 5LQQA 1O98A 3WBHA 2IUCA 4MHXA 1KHKA 5LRMA 4UOOA 1HJKA 5TJ3A 1KH4A 3NKOA 3B5QA 4UPKA 3SZYA 3UN3A 4ZG9A 2IUCB 1N2KA 3BDGB 4B56A 1EJJA 4LR7A 3KD8A 4CYRA 1KH9A 1ZEDA 3DPCA 5C66A 1N2LA 3NKPA 4LR9A 4UPLA 1E2SP 4CXKA 5L0EA 1ALJA 1AJBA 1E33P 1E3CP 2RH6A 4GTZA 5L0KA 4MY4A 3WAVA 1FSUA 3DYCA 4LQYA 2ANHA 2QZUA 1ED9A 4CYSA 1EW9A 1ZEBA 1ALHA 2ZKTA 3UO0A 4LRCA 4KAVA 4KM4A 3BDGA 2D1GA 3WAWA 1KHNA 2W5WA 2XR9A 4KJGA 2G9YA 3BDFA 5DLWA 3NKNA 1KH5A 1KHLA 5EGEA 4KAYA 2W5QA 3UNYA 2GA3A 5DLTA 3T01A 5K4PA 2IFYA 3M8ZA 1KHJA 3OT9A 4N7TA 4FDJA 3ED4A 1P49A 3UN5A 5IJSA 3NKMA 3M8WA 4QAXA 5L0BA 3MK2A 1AJAA 2W5RA 2GLQA 3NVLA 1AJDA 4UOPA 4ZG7A 4UPHA 4LRFA 3M8YA 3NKRA 2GSNA 3UN2A 1ALIA 1O99A 3IGZB 4UORA 3M7VA 1E1ZP 1HQAA 1ANIA 5GRRA 3E2DA 1URAA 3T02A 1Y7AA 4CXUA 4GTWA 4LRAA 4NWJA 1KH7A 2W5VA 2X98A 1SHQA 2W5XA 3IDDA 2GSOA 3IGYB 4LRBA 3TWZA 3TG0A 3T00A 1EW8A 5LIAA 1ZEFA 2W8DA 4GTYA 5KXAA 3Q3QA 3NKQA 1AUKA 4ZGAA 4ZG6A 4TN0A 1HDHA 1URBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W8S A;  5EGH A;  5IJQ A;  4UPI A;  4LRD A;  1EQJ A;  5HRT A;  1ELZ A;  4FDI A;  4CXS A;  5INH A;  2GSU A;  3BDH A;  3MK1 A;  3WAX A;  3MK0 A;  5DLV A;  3WAY A;  3SZZ A;  1ELY A;  4LR8 A;  2XRG A;  4GTX A;  1ANJ A;  4MIV A;  1ED8 A;  4LR2 A;  1ELX A;  1Y6V A;  3CMR A;  2VQR A;  4NWX A;  4YR1 A;  5GOV A;  1SHN A;  4KJD A;  3TX0 A;  1K7H A;  5AJ9 A;  3A52 A;  5LRN A;  1ALK A;  1B8J A;  3LXQ A;  1EI6 A;  4LRE A;  1AJC A;  2W5T A;  1EW2 A;  2W5S A;  5LQQ A;  1O98 A;  3WBH A;  2IUC A;  4MHX A;  1KHK A;  5LRM A;  4UOO A;  1HJK A;  5TJ3 A;  1KH4 A;  3NKO A;  3B5Q A;  4UPK A;  3SZY A;  3UN3 A;  4ZG9 A;  2IUC B;  1N2K A;  3BDG B;  4B56 A;  1EJJ A;  4LR7 A;  3KD8 A;  4CYR A;  1KH9 A;  1ZED A;  3DPC A;  5C66 A;  1N2L A;  3NKP A;  4LR9 A;  4UPL A;  1E2S P;  4CXK A;  5L0E A;  1ALJ A;  1AJB A;  1E33 P;  1E3C P;  2RH6 A;  4GTZ A;  5L0K A;  4MY4 A;  3WAV A;  1FSU A;  3DYC A;  4LQY A;  2ANH A;  2QZU A;  1ED9 A;  4CYS A;  1EW9 A;  1ZEB A;  1ALH A;  2ZKT A;  3UO0 A;  4LRC A;  4KAV A;  4KM4 A;  3BDG A;  2D1G A;  3WAW A;  1KHN A;  2W5W A;  2XR9 A;  4KJG A;  2G9Y A;  3BDF A;  5DLW A;  3NKN A;  1KH5 A;  1KHL A;  5EGE A;  4KAY A;  2W5Q A;  3UNY A;  2GA3 A;  5DLT A;  3T01 A;  5K4P A;  2IFY A;  3M8Z A;  1KHJ A;  3OT9 A;  4N7T A;  4FDJ A;  3ED4 A;  1P49 A;  3UN5 A;  5IJS A;  3NKM A;  3M8W A;  4QAX A;  5L0B A;  3MK2 A;  1AJA A;  2W5R A;  2GLQ A;  3NVL A;  1AJD A;  4UOP A;  4ZG7 A;  4UPH A;  4LRF A;  3M8Y A;  3NKR A;  2GSN A;  3UN2 A;  1ALI A;  1O99 A;  3IGZ B;  4UOR A;  3M7V A;  1E1Z P;  1HQA A;  1ANI A;  5GRR A;  3E2D A;  1URA A;  3T02 A;  1Y7A A;  4CXU A;  4GTW A;  4LRA A;  4NWJ A;  1KH7 A;  2W5V A;  2X98 A;  1SHQ A;  2W5X A;  3IDD A;  2GSO A;  3IGY B;  4LRB A;  3TWZ A;  3TG0 A;  3T00 A;  1EW8 A;  5LIA A;  1ZEF A;  2W8D A;  4GTY A;  5KXA A;  3Q3Q A;  3NKQ A;  1AUK A;  4ZGA A;  4ZG6 A;  4TN0 A;  1HDH A;  1URB A; 
#chains in the Genus database with same CATH topology
 2W8S A;  5EGH A;  5IJQ A;  4UPI A;  4LRD A;  1EQJ A;  5HRT A;  1ELZ A;  4FDI A;  4CXS A;  5INH A;  2GSU A;  3BDH A;  3MK1 A;  3WAX A;  3MK0 A;  5DLV A;  3WAY A;  3SZZ A;  1ELY A;  4LR8 A;  2XRG A;  4GTX A;  1ANJ A;  4MIV A;  1ED8 A;  4LR2 A;  1ELX A;  1Y6V A;  3CMR A;  2VQR A;  4NWX A;  4YR1 A;  5GOV A;  1SHN A;  4KJD A;  3TX0 A;  1K7H A;  5AJ9 A;  3A52 A;  5LRN A;  1ALK A;  1B8J A;  3LXQ A;  1EI6 A;  4LRE A;  1AJC A;  2W5T A;  1EW2 A;  2W5S A;  5LQQ A;  1O98 A;  3WBH A;  2IUC A;  4MHX A;  1KHK A;  5LRM A;  4UOO A;  1HJK A;  5TJ3 A;  1KH4 A;  3NKO A;  3B5Q A;  4UPK A;  3SZY A;  3UN3 A;  4ZG9 A;  2IUC B;  1N2K A;  3BDG B;  4B56 A;  1EJJ A;  4LR7 A;  3KD8 A;  4CYR A;  1KH9 A;  1ZED A;  3DPC A;  5C66 A;  1N2L A;  3NKP A;  4LR9 A;  4UPL A;  1E2S P;  4CXK A;  5L0E A;  1ALJ A;  1AJB A;  1E33 P;  1E3C P;  2RH6 A;  4GTZ A;  5L0K A;  4MY4 A;  3WAV A;  1FSU A;  3DYC A;  4LQY A;  2ANH A;  2QZU A;  1ED9 A;  4CYS A;  1EW9 A;  1ZEB A;  1ALH A;  2ZKT A;  3UO0 A;  4LRC A;  4KAV A;  4KM4 A;  3BDG A;  2D1G A;  3WAW A;  1KHN A;  2W5W A;  2XR9 A;  4KJG A;  2G9Y A;  3BDF A;  5DLW A;  3NKN A;  1KH5 A;  1KHL A;  5EGE A;  4KAY A;  2W5Q A;  3UNY A;  2GA3 A;  5DLT A;  3T01 A;  5K4P A;  2IFY A;  3M8Z A;  1KHJ A;  3OT9 A;  4N7T A;  4FDJ A;  3ED4 A;  1P49 A;  3UN5 A;  5IJS A;  3NKM A;  3M8W A;  4QAX A;  5L0B A;  3MK2 A;  1AJA A;  2W5R A;  2GLQ A;  3NVL A;  1AJD A;  4UOP A;  4ZG7 A;  4UPH A;  4LRF A;  3M8Y A;  3NKR A;  2GSN A;  3UN2 A;  1ALI A;  1O99 A;  3IGZ B;  4UOR A;  3M7V A;  1E1Z P;  1HQA A;  1ANI A;  5GRR A;  3E2D A;  1URA A;  3T02 A;  1Y7A A;  4CXU A;  4GTW A;  4LRA A;  4NWJ A;  1KH7 A;  2W5V A;  2X98 A;  1SHQ A;  2W5X A;  3IDD A;  2GSO A;  3IGY B;  4LRB A;  3TWZ A;  3TG0 A;  3T00 A;  1EW8 A;  5LIA A;  1ZEF A;  2W8D A;  4GTY A;  5KXA A;  3Q3Q A;  3NKQ A;  1AUK A;  4ZGA A;  4ZG6 A;  4TN0 A;  1HDH A;  1URB A; 
#chains in the Genus database with same CATH homology
 2W8S A;  5EGH A;  5IJQ A;  4UPI A;  4LRD A;  1EQJ A;  5HRT A;  1ELZ A;  4FDI A;  4CXS A;  5INH A;  2GSU A;  3BDH A;  3MK1 A;  3WAX A;  3MK0 A;  5DLV A;  3WAY A;  3SZZ A;  1ELY A;  4LR8 A;  2XRG A;  4GTX A;  1ANJ A;  4MIV A;  1ED8 A;  4LR2 A;  1ELX A;  1Y6V A;  3CMR A;  2VQR A;  4NWX A;  4YR1 A;  5GOV A;  1SHN A;  4KJD A;  3TX0 A;  1K7H A;  5AJ9 A;  3A52 A;  5LRN A;  1ALK A;  1B8J A;  3LXQ A;  1EI6 A;  4LRE A;  1AJC A;  2W5T A;  1EW2 A;  2W5S A;  5LQQ A;  1O98 A;  3WBH A;  2IUC A;  4MHX A;  1KHK A;  5LRM A;  4UOO A;  1HJK A;  5TJ3 A;  1KH4 A;  3NKO A;  3B5Q A;  4UPK A;  3SZY A;  3UN3 A;  4ZG9 A;  2IUC B;  1N2K A;  3BDG B;  4B56 A;  1EJJ A;  4LR7 A;  3KD8 A;  4CYR A;  1KH9 A;  1ZED A;  3DPC A;  5C66 A;  1N2L A;  3NKP A;  4LR9 A;  4UPL A;  1E2S P;  4CXK A;  5L0E A;  1ALJ A;  1AJB A;  1E33 P;  1E3C P;  2RH6 A;  4GTZ A;  5L0K A;  4MY4 A;  3WAV A;  1FSU A;  3DYC A;  4LQY A;  2ANH A;  2QZU A;  1ED9 A;  4CYS A;  1EW9 A;  1ZEB A;  1ALH A;  2ZKT A;  3UO0 A;  4LRC A;  4KAV A;  4KM4 A;  3BDG A;  2D1G A;  3WAW A;  1KHN A;  2W5W A;  2XR9 A;  4KJG A;  2G9Y A;  3BDF A;  5DLW A;  3NKN A;  1KH5 A;  1KHL A;  5EGE A;  4KAY A;  2W5Q A;  3UNY A;  2GA3 A;  5DLT A;  3T01 A;  5K4P A;  2IFY A;  3M8Z A;  1KHJ A;  3OT9 A;  4N7T A;  4FDJ A;  3ED4 A;  1P49 A;  3UN5 A;  5IJS A;  3NKM A;  3M8W A;  4QAX A;  5L0B A;  3MK2 A;  1AJA A;  2W5R A;  2GLQ A;  3NVL A;  1AJD A;  4UOP A;  4ZG7 A;  4UPH A;  4LRF A;  3M8Y A;  3NKR A;  2GSN A;  3UN2 A;  1ALI A;  1O99 A;  3IGZ B;  4UOR A;  3M7V A;  1E1Z P;  1HQA A;  1ANI A;  5GRR A;  3E2D A;  1URA A;  3T02 A;  1Y7A A;  4CXU A;  4GTW A;  4LRA A;  4NWJ A;  1KH7 A;  2W5V A;  2X98 A;  1SHQ A;  2W5X A;  3IDD A;  2GSO A;  3IGY B;  4LRB A;  3TWZ A;  3TG0 A;  3T00 A;  1EW8 A;  5LIA A;  1ZEF A;  2W8D A;  4GTY A;  5KXA A;  3Q3Q A;  3NKQ A;  1AUK A;  4ZGA A;  4ZG6 A;  4TN0 A;  1HDH A;  1URB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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