1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
2XR9A 5DLTA 3SZZA 4KJDA 2GSNA 2W5XA 4TN0A 1E2SP 1ALIA 2VQRA 3WBHA 4NWJA 4UPKA 1SHQA 1ZEDA 3A52A 4CXKA 4LRFA 5LRMA 3MK1A 4LREA 3UNYA 4YR1A 1EW8A 2GSOA 4QAXA 3DYCA 4LRAA 3UN5A 2XRGA 5K4PA 2W8SA 3TX0A 5KXAA 4UPLA 1KH4A 3WAYA 3BDFA 2W5TA 3KD8A 5DLVA 1ELXA 1EI6A 1O99A 1P49A 3ED4A 3Q3QA 4LQYA 4UORA 5LRNA 1HJKA 2W8DA 5LQQA 4CXUA 3TWZA 1ANIA 3WAWA 4UOOA 1EQJA 3MK0A 1HQAA 5HRTA 1AJDA 1ED8A 4GTZA 5INHA 4FDIA 3NKRA 4UPHA 5GOVA 1KH7A 3B5QA 3MK2A 3IGYB 3NKMA 4GTWA 4N7TA 3UN2A 2D1GA 5EGHA 3M8ZA 4ZGAA 4LRDA 3E2DA 4LRCA 1KHLA 4KJGA 4ZG9A 1E33P 4UPIA 4ZG7A 1ZEBA 2G9YA 1HDHA 4LR7A 4LR9A 1URBA 4MHXA 5IJQA 1Y7AA 5TJ3A 4MY4A 1AJBA 5IJSA 2GA3A 1N2LA 1ED9A 1AJCA 3M7VA 3NKPA 1AJAA 3IDDA 4B56A 1E1ZP 1ALHA 4CYRA 1B8JA 1ANJA 3TG0A 3BDGB 3IGZB 1URAA 5C66A 1KH5A 1K7HA 3LXQA 4LR2A 1ALJA 2W5WA 4ZG6A 2W5SA 2GLQA 1N2KA 4LRBA 4CXSA 1ELYA 1SHNA 2QZUA 5L0EA 3OT9A 2RH6A 1KHNA 3BDHA 1FSUA 4KAYA 4NWXA 3T02A 1KHKA 4KAVA 3UO0A 1KHJA 1O98A 4LR8A 2IUCA 2IUCB 3NVLA 1EJJA 3NKNA 5DLWA 1EW9A 1AUKA 4FDJA 2W5VA 1ZEFA 3NKQA 5L0BA 2IFYA 4GTXA 4GTYA 1ALKA 5LIAA 1E3CP 3T00A 4CYSA 2W5QA 3CMRA 4UOPA 4KM4A 3WAXA 3SZYA 3UN3A 3BDGA 1Y6VA 3M8YA 3WAVA 5GRRA 1EW2A 5L0KA 2X98A 5AJ9A 2GSUA 2ZKTA 2W5RA 3NKOA 3M8WA 2ANHA 5EGEA 1KH9A 3T01A 4MIVA 1ELZA 3DPCA
chains in the Genus database with same CATH superfamily
2XR9A 5DLTA 3SZZA 4KJDA 2GSNA 2W5XA 4TN0A 1E2SP 1ALIA 2VQRA 3WBHA 4NWJA 4UPKA 1SHQA 1ZEDA 3A52A 4CXKA 4LRFA 5LRMA 3MK1A 4LREA 3UNYA 4YR1A 1EW8A 2GSOA 4QAXA 3DYCA 4LRAA 3UN5A 2XRGA 5K4PA 2W8SA 3TX0A 5KXAA 4UPLA 1KH4A 3WAYA 3BDFA 2W5TA 3KD8A 5DLVA 1ELXA 1EI6A 1O99A 1P49A 3ED4A 3Q3QA 4LQYA 4UORA 5LRNA 1HJKA 2W8DA 5LQQA 4CXUA 3TWZA 1ANIA 3WAWA 4UOOA 1EQJA 3MK0A 1HQAA 5HRTA 1AJDA 1ED8A 4GTZA 5INHA 4FDIA 3NKRA 4UPHA 5GOVA 1KH7A 3B5QA 3MK2A 3IGYB 3NKMA 4GTWA 4N7TA 3UN2A 2D1GA 5EGHA 3M8ZA 4ZGAA 4LRDA 3E2DA 4LRCA 1KHLA 4KJGA 4ZG9A 1E33P 4UPIA 4ZG7A 1ZEBA 2G9YA 1HDHA 4LR7A 4LR9A 1URBA 4MHXA 5IJQA 1Y7AA 5TJ3A 4MY4A 1AJBA 5IJSA 2GA3A 1N2LA 1ED9A 1AJCA 3M7VA 3NKPA 1AJAA 3IDDA 4B56A 1E1ZP 1ALHA 4CYRA 1B8JA 1ANJA 3TG0A 3BDGB 3IGZB 1URAA 5C66A 1KH5A 1K7HA 3LXQA 4LR2A 1ALJA 2W5WA 4ZG6A 2W5SA 2GLQA 1N2KA 4LRBA 4CXSA 1ELYA 1SHNA 2QZUA 5L0EA 3OT9A 2RH6A 1KHNA 3BDHA 1FSUA 4KAYA 4NWXA 3T02A 1KHKA 4KAVA 3UO0A 1KHJA 1O98A 4LR8A 2IUCA 2IUCB 3NVLA 1EJJA 3NKNA 5DLWA 1EW9A 1AUKA 4FDJA 2W5VA 1ZEFA 3NKQA 5L0BA 2IFYA 4GTXA 4GTYA 1ALKA 5LIAA 1E3CP 3T00A 4CYSA 2W5QA 3CMRA 4UOPA 4KM4A 3WAXA 3SZYA 3UN3A 3BDGA 1Y6VA 3M8YA 3WAVA 5GRRA 1EW2A 5L0KA 2X98A 5AJ9A 2GSUA 2ZKTA 2W5RA 3NKOA 3M8WA 2ANHA 5EGEA 1KH9A 3T01A 4MIVA 1ELZA 3DPCA
chains in the Genus database with same CATH topology
2XR9A 5DLTA 3SZZA 4KJDA 2GSNA 2W5XA 4TN0A 1E2SP 1ALIA 2VQRA 3WBHA 4NWJA 4UPKA 1SHQA 1ZEDA 3A52A 4CXKA 4LRFA 5LRMA 3MK1A 4LREA 3UNYA 4YR1A 1EW8A 2GSOA 4QAXA 3DYCA 4LRAA 3UN5A 2XRGA 5K4PA 2W8SA 3TX0A 5KXAA 4UPLA 1KH4A 3WAYA 3BDFA 2W5TA 3KD8A 5DLVA 1ELXA 1EI6A 1O99A 1P49A 3ED4A 3Q3QA 4LQYA 4UORA 5LRNA 1HJKA 2W8DA 5LQQA 4CXUA 3TWZA 1ANIA 3WAWA 4UOOA 1EQJA 3MK0A 1HQAA 5HRTA 1AJDA 1ED8A 4GTZA 5INHA 4FDIA 3NKRA 4UPHA 5GOVA 1KH7A 3B5QA 3MK2A 3IGYB 3NKMA 4GTWA 4N7TA 3UN2A 2D1GA 5EGHA 3M8ZA 4ZGAA 4LRDA 3E2DA 4LRCA 1KHLA 4KJGA 4ZG9A 1E33P 4UPIA 4ZG7A 1ZEBA 2G9YA 1HDHA 4LR7A 4LR9A 1URBA 4MHXA 5IJQA 1Y7AA 5TJ3A 4MY4A 1AJBA 5IJSA 2GA3A 1N2LA 1ED9A 1AJCA 3M7VA 3NKPA 1AJAA 3IDDA 4B56A 1E1ZP 1ALHA 4CYRA 1B8JA 1ANJA 3TG0A 3BDGB 3IGZB 1URAA 5C66A 1KH5A 1K7HA 3LXQA 4LR2A 1ALJA 2W5WA 4ZG6A 2W5SA 2GLQA 1N2KA 4LRBA 4CXSA 1ELYA 1SHNA 2QZUA 5L0EA 3OT9A 2RH6A 1KHNA 3BDHA 1FSUA 4KAYA 4NWXA 3T02A 1KHKA 4KAVA 3UO0A 1KHJA 1O98A 4LR8A 2IUCA 2IUCB 3NVLA 1EJJA 3NKNA 5DLWA 1EW9A 1AUKA 4FDJA 2W5VA 1ZEFA 3NKQA 5L0BA 2IFYA 4GTXA 4GTYA 1ALKA 5LIAA 1E3CP 3T00A 4CYSA 2W5QA 3CMRA 4UOPA 4KM4A 3WAXA 3SZYA 3UN3A 3BDGA 1Y6VA 3M8YA 3WAVA 5GRRA 1EW2A 5L0KA 2X98A 5AJ9A 2GSUA 2ZKTA 2W5RA 3NKOA 3M8WA 2ANHA 5EGEA 1KH9A 3T01A 4MIVA 1ELZA 3DPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XR9 A;  5DLT A;  3SZZ A;  4KJD A;  2GSN A;  2W5X A;  4TN0 A;  1E2S P;  1ALI A;  2VQR A;  3WBH A;  4NWJ A;  4UPK A;  1SHQ A;  1ZED A;  3A52 A;  4CXK A;  4LRF A;  5LRM A;  3MK1 A;  4LRE A;  3UNY A;  4YR1 A;  1EW8 A;  2GSO A;  4QAX A;  3DYC A;  4LRA A;  3UN5 A;  2XRG A;  5K4P A;  2W8S A;  3TX0 A;  5KXA A;  4UPL A;  1KH4 A;  3WAY A;  3BDF A;  2W5T A;  3KD8 A;  5DLV A;  1ELX A;  1EI6 A;  1O99 A;  1P49 A;  3ED4 A;  3Q3Q A;  4LQY A;  4UOR A;  5LRN A;  1HJK A;  2W8D A;  5LQQ A;  4CXU A;  3TWZ A;  1ANI A;  3WAW A;  4UOO A;  1EQJ A;  3MK0 A;  1HQA A;  5HRT A;  1AJD A;  1ED8 A;  4GTZ A;  5INH A;  4FDI A;  3NKR A;  4UPH A;  5GOV A;  1KH7 A;  3B5Q A;  3MK2 A;  3IGY B;  3NKM A;  4GTW A;  4N7T A;  3UN2 A;  2D1G A;  5EGH A;  3M8Z A;  4ZGA A;  4LRD A;  3E2D A;  4LRC A;  1KHL A;  4KJG A;  4ZG9 A;  1E33 P;  4UPI A;  4ZG7 A;  1ZEB A;  2G9Y A;  1HDH A;  4LR7 A;  4LR9 A;  1URB A;  4MHX A;  5IJQ A;  1Y7A A;  5TJ3 A;  4MY4 A;  1AJB A;  5IJS A;  2GA3 A;  1N2L A;  1ED9 A;  1AJC A;  3M7V A;  3NKP A;  1AJA A;  3IDD A;  4B56 A;  1E1Z P;  1ALH A;  4CYR A;  1B8J A;  1ANJ A;  3TG0 A;  3BDG B;  3IGZ B;  1URA A;  5C66 A;  1KH5 A;  1K7H A;  3LXQ A;  4LR2 A;  1ALJ A;  2W5W A;  4ZG6 A;  2W5S A;  2GLQ A;  1N2K A;  4LRB A;  4CXS A;  1ELY A;  1SHN A;  2QZU A;  5L0E A;  3OT9 A;  2RH6 A;  1KHN A;  3BDH A;  1FSU A;  4KAY A;  4NWX A;  3T02 A;  1KHK A;  4KAV A;  3UO0 A;  1KHJ A;  1O98 A;  4LR8 A;  2IUC A;  2IUC B;  3NVL A;  1EJJ A;  3NKN A;  5DLW A;  1EW9 A;  1AUK A;  4FDJ A;  2W5V A;  1ZEF A;  3NKQ A;  5L0B A;  2IFY A;  4GTX A;  4GTY A;  1ALK A;  5LIA A;  1E3C P;  3T00 A;  4CYS A;  2W5Q A;  3CMR A;  4UOP A;  4KM4 A;  3WAX A;  3SZY A;  3UN3 A;  3BDG A;  1Y6V A;  3M8Y A;  3WAV A;  5GRR A;  1EW2 A;  5L0K A;  2X98 A;  5AJ9 A;  2GSU A;  2ZKT A;  2W5R A;  3NKO A;  3M8W A;  2ANH A;  5EGE A;  1KH9 A;  3T01 A;  4MIV A;  1ELZ A;  3DPC A; 
#chains in the Genus database with same CATH topology
 2XR9 A;  5DLT A;  3SZZ A;  4KJD A;  2GSN A;  2W5X A;  4TN0 A;  1E2S P;  1ALI A;  2VQR A;  3WBH A;  4NWJ A;  4UPK A;  1SHQ A;  1ZED A;  3A52 A;  4CXK A;  4LRF A;  5LRM A;  3MK1 A;  4LRE A;  3UNY A;  4YR1 A;  1EW8 A;  2GSO A;  4QAX A;  3DYC A;  4LRA A;  3UN5 A;  2XRG A;  5K4P A;  2W8S A;  3TX0 A;  5KXA A;  4UPL A;  1KH4 A;  3WAY A;  3BDF A;  2W5T A;  3KD8 A;  5DLV A;  1ELX A;  1EI6 A;  1O99 A;  1P49 A;  3ED4 A;  3Q3Q A;  4LQY A;  4UOR A;  5LRN A;  1HJK A;  2W8D A;  5LQQ A;  4CXU A;  3TWZ A;  1ANI A;  3WAW A;  4UOO A;  1EQJ A;  3MK0 A;  1HQA A;  5HRT A;  1AJD A;  1ED8 A;  4GTZ A;  5INH A;  4FDI A;  3NKR A;  4UPH A;  5GOV A;  1KH7 A;  3B5Q A;  3MK2 A;  3IGY B;  3NKM A;  4GTW A;  4N7T A;  3UN2 A;  2D1G A;  5EGH A;  3M8Z A;  4ZGA A;  4LRD A;  3E2D A;  4LRC A;  1KHL A;  4KJG A;  4ZG9 A;  1E33 P;  4UPI A;  4ZG7 A;  1ZEB A;  2G9Y A;  1HDH A;  4LR7 A;  4LR9 A;  1URB A;  4MHX A;  5IJQ A;  1Y7A A;  5TJ3 A;  4MY4 A;  1AJB A;  5IJS A;  2GA3 A;  1N2L A;  1ED9 A;  1AJC A;  3M7V A;  3NKP A;  1AJA A;  3IDD A;  4B56 A;  1E1Z P;  1ALH A;  4CYR A;  1B8J A;  1ANJ A;  3TG0 A;  3BDG B;  3IGZ B;  1URA A;  5C66 A;  1KH5 A;  1K7H A;  3LXQ A;  4LR2 A;  1ALJ A;  2W5W A;  4ZG6 A;  2W5S A;  2GLQ A;  1N2K A;  4LRB A;  4CXS A;  1ELY A;  1SHN A;  2QZU A;  5L0E A;  3OT9 A;  2RH6 A;  1KHN A;  3BDH A;  1FSU A;  4KAY A;  4NWX A;  3T02 A;  1KHK A;  4KAV A;  3UO0 A;  1KHJ A;  1O98 A;  4LR8 A;  2IUC A;  2IUC B;  3NVL A;  1EJJ A;  3NKN A;  5DLW A;  1EW9 A;  1AUK A;  4FDJ A;  2W5V A;  1ZEF A;  3NKQ A;  5L0B A;  2IFY A;  4GTX A;  4GTY A;  1ALK A;  5LIA A;  1E3C P;  3T00 A;  4CYS A;  2W5Q A;  3CMR A;  4UOP A;  4KM4 A;  3WAX A;  3SZY A;  3UN3 A;  3BDG A;  1Y6V A;  3M8Y A;  3WAV A;  5GRR A;  1EW2 A;  5L0K A;  2X98 A;  5AJ9 A;  2GSU A;  2ZKT A;  2W5R A;  3NKO A;  3M8W A;  2ANH A;  5EGE A;  1KH9 A;  3T01 A;  4MIV A;  1ELZ A;  3DPC A; 
#chains in the Genus database with same CATH homology
 2XR9 A;  5DLT A;  3SZZ A;  4KJD A;  2GSN A;  2W5X A;  4TN0 A;  1E2S P;  1ALI A;  2VQR A;  3WBH A;  4NWJ A;  4UPK A;  1SHQ A;  1ZED A;  3A52 A;  4CXK A;  4LRF A;  5LRM A;  3MK1 A;  4LRE A;  3UNY A;  4YR1 A;  1EW8 A;  2GSO A;  4QAX A;  3DYC A;  4LRA A;  3UN5 A;  2XRG A;  5K4P A;  2W8S A;  3TX0 A;  5KXA A;  4UPL A;  1KH4 A;  3WAY A;  3BDF A;  2W5T A;  3KD8 A;  5DLV A;  1ELX A;  1EI6 A;  1O99 A;  1P49 A;  3ED4 A;  3Q3Q A;  4LQY A;  4UOR A;  5LRN A;  1HJK A;  2W8D A;  5LQQ A;  4CXU A;  3TWZ A;  1ANI A;  3WAW A;  4UOO A;  1EQJ A;  3MK0 A;  1HQA A;  5HRT A;  1AJD A;  1ED8 A;  4GTZ A;  5INH A;  4FDI A;  3NKR A;  4UPH A;  5GOV A;  1KH7 A;  3B5Q A;  3MK2 A;  3IGY B;  3NKM A;  4GTW A;  4N7T A;  3UN2 A;  2D1G A;  5EGH A;  3M8Z A;  4ZGA A;  4LRD A;  3E2D A;  4LRC A;  1KHL A;  4KJG A;  4ZG9 A;  1E33 P;  4UPI A;  4ZG7 A;  1ZEB A;  2G9Y A;  1HDH A;  4LR7 A;  4LR9 A;  1URB A;  4MHX A;  5IJQ A;  1Y7A A;  5TJ3 A;  4MY4 A;  1AJB A;  5IJS A;  2GA3 A;  1N2L A;  1ED9 A;  1AJC A;  3M7V A;  3NKP A;  1AJA A;  3IDD A;  4B56 A;  1E1Z P;  1ALH A;  4CYR A;  1B8J A;  1ANJ A;  3TG0 A;  3BDG B;  3IGZ B;  1URA A;  5C66 A;  1KH5 A;  1K7H A;  3LXQ A;  4LR2 A;  1ALJ A;  2W5W A;  4ZG6 A;  2W5S A;  2GLQ A;  1N2K A;  4LRB A;  4CXS A;  1ELY A;  1SHN A;  2QZU A;  5L0E A;  3OT9 A;  2RH6 A;  1KHN A;  3BDH A;  1FSU A;  4KAY A;  4NWX A;  3T02 A;  1KHK A;  4KAV A;  3UO0 A;  1KHJ A;  1O98 A;  4LR8 A;  2IUC A;  2IUC B;  3NVL A;  1EJJ A;  3NKN A;  5DLW A;  1EW9 A;  1AUK A;  4FDJ A;  2W5V A;  1ZEF A;  3NKQ A;  5L0B A;  2IFY A;  4GTX A;  4GTY A;  1ALK A;  5LIA A;  1E3C P;  3T00 A;  4CYS A;  2W5Q A;  3CMR A;  4UOP A;  4KM4 A;  3WAX A;  3SZY A;  3UN3 A;  3BDG A;  1Y6V A;  3M8Y A;  3WAV A;  5GRR A;  1EW2 A;  5L0K A;  2X98 A;  5AJ9 A;  2GSU A;  2ZKT A;  2W5R A;  3NKO A;  3M8W A;  2ANH A;  5EGE A;  1KH9 A;  3T01 A;  4MIV A;  1ELZ A;  3DPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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