1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
4LR7A 3DPCA 3TWZA 3UNYA 1ELXA 4LQYA 3WAYA 2GSNA 1EI6A 3IGYB 5K4PA 3IDDA 3NKMA 1ZEFA 1EQJA 1EJJA 1ALHA 4LRAA 3A52A 1ANIA 1HQAA 1AJCA 4UORA 3WAXA 1E1ZP 3NVLA 5LRNA 1P49A 1EW2A 4CXUA 3BDHA 2ZKTA 4GTXA 1Y6VA 1ZEDA 5DLWA 5L0KA 3T02A 4LRFA 5GOVA 3IGZB 4UOOA 3NKPA 1SHNA 1E3CP 3UN5A 1N2LA 4CXSA 1N2KA 2W5RA 4GTYA 2VQRA 4GTWA 2W5WA 1ED9A 4UPLA 3WAWA 3NKOA 1ZEBA 1ED8A 3CMRA 4CXKA 2G9YA 2W8SA 2ANHA 5IJSA 4MIVA 4MY4A 1E2SP 5LIAA 2GSUA 4KAVA 2X98A 3T00A 2GLQA 4LR8A 1B8JA 4UPIA 5DLTA 4GTZA 2W8DA 1KHNA 1Y7AA 3NKRA 5GRRA 3MK2A 3SZYA 5LRMA 4ZG6A 2W5QA 3UO0A 4LRBA 4CYRA 3M8WA 4ZG7A 1URBA 2XR9A 4NWXA 1KHJA 1O99A 1KHKA 5L0BA 1SHQA 2GA3A 5C66A 4UPKA 1O98A 4TN0A 1KH9A 3BDGA 4UOPA 2GSOA 4LR9A 5INHA 1URAA 3DYCA 3NKNA 2IFYA 1ALIA 4KAYA 3MK0A 1ALJA 1E33P 4KJDA 3WBHA 3TG0A 2D1GA 1EW9A 1K7HA 3BDFA 3WAVA 2W5SA 1HJKA 1ELZA 3BDGB 4KM4A 4ZGAA 1ALKA 5EGEA 1AJAA 1KH7A 3M8ZA 2XRGA 2QZUA 4QAXA 2IUCA 4ZG9A 5HRTA 3KD8A 1ELYA 4UPHA 3M8YA 1KH4A 3T01A 3MK1A 4CYSA 3UN3A 2RH6A 4MHXA 4B56A 1FSUA 2W5XA 3NKQA 1AUKA 1ANJA 1HDHA 5DLVA 3Q3QA 5AJ9A 2IUCB 4LRCA 3E2DA 5L0EA 1AJBA 4KJGA 1EW8A 4LR2A 5EGHA 5KXAA 5IJQA 4N7TA 4LREA 3SZZA 2W5VA 3M7VA 4FDJA 2W5TA 5TJ3A 3B5QA 3LXQA 3UN2A 4NWJA 3OT9A 4FDIA 4LRDA 3TX0A 5LQQA 4YR1A 3ED4A 1AJDA 1KHLA 1KH5A
chains in the Genus database with same CATH superfamily
4LR7A 3DPCA 3TWZA 3UNYA 1ELXA 4LQYA 3WAYA 2GSNA 1EI6A 3IGYB 5K4PA 3IDDA 3NKMA 1ZEFA 1EQJA 1EJJA 1ALHA 4LRAA 3A52A 1ANIA 1HQAA 1AJCA 4UORA 3WAXA 1E1ZP 3NVLA 5LRNA 1P49A 1EW2A 4CXUA 3BDHA 2ZKTA 4GTXA 1Y6VA 1ZEDA 5DLWA 5L0KA 3T02A 4LRFA 5GOVA 3IGZB 4UOOA 3NKPA 1SHNA 1E3CP 3UN5A 1N2LA 4CXSA 1N2KA 2W5RA 4GTYA 2VQRA 4GTWA 2W5WA 1ED9A 4UPLA 3WAWA 3NKOA 1ZEBA 1ED8A 3CMRA 4CXKA 2G9YA 2W8SA 2ANHA 5IJSA 4MIVA 4MY4A 1E2SP 5LIAA 2GSUA 4KAVA 2X98A 3T00A 2GLQA 4LR8A 1B8JA 4UPIA 5DLTA 4GTZA 2W8DA 1KHNA 1Y7AA 3NKRA 5GRRA 3MK2A 3SZYA 5LRMA 4ZG6A 2W5QA 3UO0A 4LRBA 4CYRA 3M8WA 4ZG7A 1URBA 2XR9A 4NWXA 1KHJA 1O99A 1KHKA 5L0BA 1SHQA 2GA3A 5C66A 4UPKA 1O98A 4TN0A 1KH9A 3BDGA 4UOPA 2GSOA 4LR9A 5INHA 1URAA 3DYCA 3NKNA 2IFYA 1ALIA 4KAYA 3MK0A 1ALJA 1E33P 4KJDA 3WBHA 3TG0A 2D1GA 1EW9A 1K7HA 3BDFA 3WAVA 2W5SA 1HJKA 1ELZA 3BDGB 4KM4A 4ZGAA 1ALKA 5EGEA 1AJAA 1KH7A 3M8ZA 2XRGA 2QZUA 4QAXA 2IUCA 4ZG9A 5HRTA 3KD8A 1ELYA 4UPHA 3M8YA 1KH4A 3T01A 3MK1A 4CYSA 3UN3A 2RH6A 4MHXA 4B56A 1FSUA 2W5XA 3NKQA 1AUKA 1ANJA 1HDHA 5DLVA 3Q3QA 5AJ9A 2IUCB 4LRCA 3E2DA 5L0EA 1AJBA 4KJGA 1EW8A 4LR2A 5EGHA 5KXAA 5IJQA 4N7TA 4LREA 3SZZA 2W5VA 3M7VA 4FDJA 2W5TA 5TJ3A 3B5QA 3LXQA 3UN2A 4NWJA 3OT9A 4FDIA 4LRDA 3TX0A 5LQQA 4YR1A 3ED4A 1AJDA 1KHLA 1KH5A
chains in the Genus database with same CATH topology
4LR7A 3DPCA 3TWZA 3UNYA 1ELXA 4LQYA 3WAYA 2GSNA 1EI6A 3IGYB 5K4PA 3IDDA 3NKMA 1ZEFA 1EQJA 1EJJA 1ALHA 4LRAA 3A52A 1ANIA 1HQAA 1AJCA 4UORA 3WAXA 1E1ZP 3NVLA 5LRNA 1P49A 1EW2A 4CXUA 3BDHA 2ZKTA 4GTXA 1Y6VA 1ZEDA 5DLWA 5L0KA 3T02A 4LRFA 5GOVA 3IGZB 4UOOA 3NKPA 1SHNA 1E3CP 3UN5A 1N2LA 4CXSA 1N2KA 2W5RA 4GTYA 2VQRA 4GTWA 2W5WA 1ED9A 4UPLA 3WAWA 3NKOA 1ZEBA 1ED8A 3CMRA 4CXKA 2G9YA 2W8SA 2ANHA 5IJSA 4MIVA 4MY4A 1E2SP 5LIAA 2GSUA 4KAVA 2X98A 3T00A 2GLQA 4LR8A 1B8JA 4UPIA 5DLTA 4GTZA 2W8DA 1KHNA 1Y7AA 3NKRA 5GRRA 3MK2A 3SZYA 5LRMA 4ZG6A 2W5QA 3UO0A 4LRBA 4CYRA 3M8WA 4ZG7A 1URBA 2XR9A 4NWXA 1KHJA 1O99A 1KHKA 5L0BA 1SHQA 2GA3A 5C66A 4UPKA 1O98A 4TN0A 1KH9A 3BDGA 4UOPA 2GSOA 4LR9A 5INHA 1URAA 3DYCA 3NKNA 2IFYA 1ALIA 4KAYA 3MK0A 1ALJA 1E33P 4KJDA 3WBHA 3TG0A 2D1GA 1EW9A 1K7HA 3BDFA 3WAVA 2W5SA 1HJKA 1ELZA 3BDGB 4KM4A 4ZGAA 1ALKA 5EGEA 1AJAA 1KH7A 3M8ZA 2XRGA 2QZUA 4QAXA 2IUCA 4ZG9A 5HRTA 3KD8A 1ELYA 4UPHA 3M8YA 1KH4A 3T01A 3MK1A 4CYSA 3UN3A 2RH6A 4MHXA 4B56A 1FSUA 2W5XA 3NKQA 1AUKA 1ANJA 1HDHA 5DLVA 3Q3QA 5AJ9A 2IUCB 4LRCA 3E2DA 5L0EA 1AJBA 4KJGA 1EW8A 4LR2A 5EGHA 5KXAA 5IJQA 4N7TA 4LREA 3SZZA 2W5VA 3M7VA 4FDJA 2W5TA 5TJ3A 3B5QA 3LXQA 3UN2A 4NWJA 3OT9A 4FDIA 4LRDA 3TX0A 5LQQA 4YR1A 3ED4A 1AJDA 1KHLA 1KH5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR7 A;  3DPC A;  3TWZ A;  3UNY A;  1ELX A;  4LQY A;  3WAY A;  2GSN A;  1EI6 A;  3IGY B;  5K4P A;  3IDD A;  3NKM A;  1ZEF A;  1EQJ A;  1EJJ A;  1ALH A;  4LRA A;  3A52 A;  1ANI A;  1HQA A;  1AJC A;  4UOR A;  3WAX A;  1E1Z P;  3NVL A;  5LRN A;  1P49 A;  1EW2 A;  4CXU A;  3BDH A;  2ZKT A;  4GTX A;  1Y6V A;  1ZED A;  5DLW A;  5L0K A;  3T02 A;  4LRF A;  5GOV A;  3IGZ B;  4UOO A;  3NKP A;  1SHN A;  1E3C P;  3UN5 A;  1N2L A;  4CXS A;  1N2K A;  2W5R A;  4GTY A;  2VQR A;  4GTW A;  2W5W A;  1ED9 A;  4UPL A;  3WAW A;  3NKO A;  1ZEB A;  1ED8 A;  3CMR A;  4CXK A;  2G9Y A;  2W8S A;  2ANH A;  5IJS A;  4MIV A;  4MY4 A;  1E2S P;  5LIA A;  2GSU A;  4KAV A;  2X98 A;  3T00 A;  2GLQ A;  4LR8 A;  1B8J A;  4UPI A;  5DLT A;  4GTZ A;  2W8D A;  1KHN A;  1Y7A A;  3NKR A;  5GRR A;  3MK2 A;  3SZY A;  5LRM A;  4ZG6 A;  2W5Q A;  3UO0 A;  4LRB A;  4CYR A;  3M8W A;  4ZG7 A;  1URB A;  2XR9 A;  4NWX A;  1KHJ A;  1O99 A;  1KHK A;  5L0B A;  1SHQ A;  2GA3 A;  5C66 A;  4UPK A;  1O98 A;  4TN0 A;  1KH9 A;  3BDG A;  4UOP A;  2GSO A;  4LR9 A;  5INH A;  1URA A;  3DYC A;  3NKN A;  2IFY A;  1ALI A;  4KAY A;  3MK0 A;  1ALJ A;  1E33 P;  4KJD A;  3WBH A;  3TG0 A;  2D1G A;  1EW9 A;  1K7H A;  3BDF A;  3WAV A;  2W5S A;  1HJK A;  1ELZ A;  3BDG B;  4KM4 A;  4ZGA A;  1ALK A;  5EGE A;  1AJA A;  1KH7 A;  3M8Z A;  2XRG A;  2QZU A;  4QAX A;  2IUC A;  4ZG9 A;  5HRT A;  3KD8 A;  1ELY A;  4UPH A;  3M8Y A;  1KH4 A;  3T01 A;  3MK1 A;  4CYS A;  3UN3 A;  2RH6 A;  4MHX A;  4B56 A;  1FSU A;  2W5X A;  3NKQ A;  1AUK A;  1ANJ A;  1HDH A;  5DLV A;  3Q3Q A;  5AJ9 A;  2IUC B;  4LRC A;  3E2D A;  5L0E A;  1AJB A;  4KJG A;  1EW8 A;  4LR2 A;  5EGH A;  5KXA A;  5IJQ A;  4N7T A;  4LRE A;  3SZZ A;  2W5V A;  3M7V A;  4FDJ A;  2W5T A;  5TJ3 A;  3B5Q A;  3LXQ A;  3UN2 A;  4NWJ A;  3OT9 A;  4FDI A;  4LRD A;  3TX0 A;  5LQQ A;  4YR1 A;  3ED4 A;  1AJD A;  1KHL A;  1KH5 A; 
#chains in the Genus database with same CATH topology
 4LR7 A;  3DPC A;  3TWZ A;  3UNY A;  1ELX A;  4LQY A;  3WAY A;  2GSN A;  1EI6 A;  3IGY B;  5K4P A;  3IDD A;  3NKM A;  1ZEF A;  1EQJ A;  1EJJ A;  1ALH A;  4LRA A;  3A52 A;  1ANI A;  1HQA A;  1AJC A;  4UOR A;  3WAX A;  1E1Z P;  3NVL A;  5LRN A;  1P49 A;  1EW2 A;  4CXU A;  3BDH A;  2ZKT A;  4GTX A;  1Y6V A;  1ZED A;  5DLW A;  5L0K A;  3T02 A;  4LRF A;  5GOV A;  3IGZ B;  4UOO A;  3NKP A;  1SHN A;  1E3C P;  3UN5 A;  1N2L A;  4CXS A;  1N2K A;  2W5R A;  4GTY A;  2VQR A;  4GTW A;  2W5W A;  1ED9 A;  4UPL A;  3WAW A;  3NKO A;  1ZEB A;  1ED8 A;  3CMR A;  4CXK A;  2G9Y A;  2W8S A;  2ANH A;  5IJS A;  4MIV A;  4MY4 A;  1E2S P;  5LIA A;  2GSU A;  4KAV A;  2X98 A;  3T00 A;  2GLQ A;  4LR8 A;  1B8J A;  4UPI A;  5DLT A;  4GTZ A;  2W8D A;  1KHN A;  1Y7A A;  3NKR A;  5GRR A;  3MK2 A;  3SZY A;  5LRM A;  4ZG6 A;  2W5Q A;  3UO0 A;  4LRB A;  4CYR A;  3M8W A;  4ZG7 A;  1URB A;  2XR9 A;  4NWX A;  1KHJ A;  1O99 A;  1KHK A;  5L0B A;  1SHQ A;  2GA3 A;  5C66 A;  4UPK A;  1O98 A;  4TN0 A;  1KH9 A;  3BDG A;  4UOP A;  2GSO A;  4LR9 A;  5INH A;  1URA A;  3DYC A;  3NKN A;  2IFY A;  1ALI A;  4KAY A;  3MK0 A;  1ALJ A;  1E33 P;  4KJD A;  3WBH A;  3TG0 A;  2D1G A;  1EW9 A;  1K7H A;  3BDF A;  3WAV A;  2W5S A;  1HJK A;  1ELZ A;  3BDG B;  4KM4 A;  4ZGA A;  1ALK A;  5EGE A;  1AJA A;  1KH7 A;  3M8Z A;  2XRG A;  2QZU A;  4QAX A;  2IUC A;  4ZG9 A;  5HRT A;  3KD8 A;  1ELY A;  4UPH A;  3M8Y A;  1KH4 A;  3T01 A;  3MK1 A;  4CYS A;  3UN3 A;  2RH6 A;  4MHX A;  4B56 A;  1FSU A;  2W5X A;  3NKQ A;  1AUK A;  1ANJ A;  1HDH A;  5DLV A;  3Q3Q A;  5AJ9 A;  2IUC B;  4LRC A;  3E2D A;  5L0E A;  1AJB A;  4KJG A;  1EW8 A;  4LR2 A;  5EGH A;  5KXA A;  5IJQ A;  4N7T A;  4LRE A;  3SZZ A;  2W5V A;  3M7V A;  4FDJ A;  2W5T A;  5TJ3 A;  3B5Q A;  3LXQ A;  3UN2 A;  4NWJ A;  3OT9 A;  4FDI A;  4LRD A;  3TX0 A;  5LQQ A;  4YR1 A;  3ED4 A;  1AJD A;  1KHL A;  1KH5 A; 
#chains in the Genus database with same CATH homology
 4LR7 A;  3DPC A;  3TWZ A;  3UNY A;  1ELX A;  4LQY A;  3WAY A;  2GSN A;  1EI6 A;  3IGY B;  5K4P A;  3IDD A;  3NKM A;  1ZEF A;  1EQJ A;  1EJJ A;  1ALH A;  4LRA A;  3A52 A;  1ANI A;  1HQA A;  1AJC A;  4UOR A;  3WAX A;  1E1Z P;  3NVL A;  5LRN A;  1P49 A;  1EW2 A;  4CXU A;  3BDH A;  2ZKT A;  4GTX A;  1Y6V A;  1ZED A;  5DLW A;  5L0K A;  3T02 A;  4LRF A;  5GOV A;  3IGZ B;  4UOO A;  3NKP A;  1SHN A;  1E3C P;  3UN5 A;  1N2L A;  4CXS A;  1N2K A;  2W5R A;  4GTY A;  2VQR A;  4GTW A;  2W5W A;  1ED9 A;  4UPL A;  3WAW A;  3NKO A;  1ZEB A;  1ED8 A;  3CMR A;  4CXK A;  2G9Y A;  2W8S A;  2ANH A;  5IJS A;  4MIV A;  4MY4 A;  1E2S P;  5LIA A;  2GSU A;  4KAV A;  2X98 A;  3T00 A;  2GLQ A;  4LR8 A;  1B8J A;  4UPI A;  5DLT A;  4GTZ A;  2W8D A;  1KHN A;  1Y7A A;  3NKR A;  5GRR A;  3MK2 A;  3SZY A;  5LRM A;  4ZG6 A;  2W5Q A;  3UO0 A;  4LRB A;  4CYR A;  3M8W A;  4ZG7 A;  1URB A;  2XR9 A;  4NWX A;  1KHJ A;  1O99 A;  1KHK A;  5L0B A;  1SHQ A;  2GA3 A;  5C66 A;  4UPK A;  1O98 A;  4TN0 A;  1KH9 A;  3BDG A;  4UOP A;  2GSO A;  4LR9 A;  5INH A;  1URA A;  3DYC A;  3NKN A;  2IFY A;  1ALI A;  4KAY A;  3MK0 A;  1ALJ A;  1E33 P;  4KJD A;  3WBH A;  3TG0 A;  2D1G A;  1EW9 A;  1K7H A;  3BDF A;  3WAV A;  2W5S A;  1HJK A;  1ELZ A;  3BDG B;  4KM4 A;  4ZGA A;  1ALK A;  5EGE A;  1AJA A;  1KH7 A;  3M8Z A;  2XRG A;  2QZU A;  4QAX A;  2IUC A;  4ZG9 A;  5HRT A;  3KD8 A;  1ELY A;  4UPH A;  3M8Y A;  1KH4 A;  3T01 A;  3MK1 A;  4CYS A;  3UN3 A;  2RH6 A;  4MHX A;  4B56 A;  1FSU A;  2W5X A;  3NKQ A;  1AUK A;  1ANJ A;  1HDH A;  5DLV A;  3Q3Q A;  5AJ9 A;  2IUC B;  4LRC A;  3E2D A;  5L0E A;  1AJB A;  4KJG A;  1EW8 A;  4LR2 A;  5EGH A;  5KXA A;  5IJQ A;  4N7T A;  4LRE A;  3SZZ A;  2W5V A;  3M7V A;  4FDJ A;  2W5T A;  5TJ3 A;  3B5Q A;  3LXQ A;  3UN2 A;  4NWJ A;  3OT9 A;  4FDI A;  4LRD A;  3TX0 A;  5LQQ A;  4YR1 A;  3ED4 A;  1AJD A;  1KHL A;  1KH5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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