1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Total Genus 144
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
144
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Alkaline phosphatase
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 144
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
1EW2A 5TJ3A 4YR1A 1ED9A 1EW9A 3LXQA 1HDHA 3M8WA 1KHLA 3NKOA 4CXUA 4LR8A 4CYSA 2G9YA 4ZG7A 1EI6A 1HJKA 4KAVA 1ZEFA 1ELYA 3TG0A 5HRTA 2IUCB 1O98A 1KH9A 4TN0A 4LRAA 5LRMA 2GSOA 1ELZA 3UNYA 1E2SP 1Y7AA 5EGHA 1ALKA 3WAYA 1N2KA 2XR9A 3OT9A 3DYCA 2D1GA 4CXSA 2W8SA 3NKQA 4UPKA 3NKNA 2VQRA 2W5QA 3UN2A 4N7TA 3BDHA 1AJBA 4GTXA 1E33P 4NWXA 1ALJA 5EGEA 4UOOA 1KH4A 3M8ZA 1Y6VA 4LRFA 4CYRA 1B8JA 1KHKA 1E3CP 3BDFA 3IDDA 4NWJA 4MY4A 3SZYA 3WBHA 5C66A 1P49A 1ANIA 4LR9A 5GRRA 3M7VA 3TWZA 3UO0A 4MHXA 1AJDA 4LR7A 1ANJA 4CXKA 2IFYA 2W5RA 4KJDA 4LREA 1HQAA 3UN3A 1EW8A 1ZEDA 3ED4A 5L0KA 3KD8A 2W8DA 2IUCA 3T02A 2GSUA 4UPIA 1ALIA 5KXAA 3BDGB 3NKRA 4GTYA 3A52A 4LRDA 5LQQA 4GTZA 4KJGA 2W5SA 2W5VA 3TX0A 3T01A 1E1ZP 2W5XA 4FDIA 1ALHA 2ZKTA 5AJ9A 4LR2A 2GA3A 1ELXA 5LRNA 1FSUA 4KM4A 3SZZA 1KH7A 2GLQA 1SHNA 1SHQA 5K4PA 2W5TA 2QZUA 3DPCA 1N2LA 3IGZB 5DLWA 1AJAA 4UPLA 1EQJA 5L0EA 3M8YA 1ZEBA 1KHJA 3NKPA 4LQYA 5DLVA 4GTWA 4ZGAA 4LRCA 3CMRA 4UPHA 5INHA 3MK0A 3NVLA 1URBA 4UOPA 3MK2A 3WAVA 1EJJA 4QAXA 1ED8A 2W5WA 1KHNA 3T00A 1KH5A 3WAXA 2XRGA 3NKMA 4B56A 2X98A 1O99A 4LRBA 3WAWA 2GSNA 2ANHA 4UORA 3BDGA 3IGYB 4FDJA 1K7HA 5IJSA 5L0BA 5IJQA 1AUKA 5LIAA 3E2DA 1AJCA 4KAYA 3UN5A 4MIVA 3Q3QA 5GOVA 4ZG9A 1URAA 3MK1A 4ZG6A 2RH6A 3B5QA 5DLTA
chains in the Genus database with same CATH superfamily
1EW2A 5TJ3A 4YR1A 1ED9A 1EW9A 3LXQA 1HDHA 3M8WA 1KHLA 3NKOA 4CXUA 4LR8A 4CYSA 2G9YA 4ZG7A 1EI6A 1HJKA 4KAVA 1ZEFA 1ELYA 3TG0A 5HRTA 2IUCB 1O98A 1KH9A 4TN0A 4LRAA 5LRMA 2GSOA 1ELZA 3UNYA 1E2SP 1Y7AA 5EGHA 1ALKA 3WAYA 1N2KA 2XR9A 3OT9A 3DYCA 2D1GA 4CXSA 2W8SA 3NKQA 4UPKA 3NKNA 2VQRA 2W5QA 3UN2A 4N7TA 3BDHA 1AJBA 4GTXA 1E33P 4NWXA 1ALJA 5EGEA 4UOOA 1KH4A 3M8ZA 1Y6VA 4LRFA 4CYRA 1B8JA 1KHKA 1E3CP 3BDFA 3IDDA 4NWJA 4MY4A 3SZYA 3WBHA 5C66A 1P49A 1ANIA 4LR9A 5GRRA 3M7VA 3TWZA 3UO0A 4MHXA 1AJDA 4LR7A 1ANJA 4CXKA 2IFYA 2W5RA 4KJDA 4LREA 1HQAA 3UN3A 1EW8A 1ZEDA 3ED4A 5L0KA 3KD8A 2W8DA 2IUCA 3T02A 2GSUA 4UPIA 1ALIA 5KXAA 3BDGB 3NKRA 4GTYA 3A52A 4LRDA 5LQQA 4GTZA 4KJGA 2W5SA 2W5VA 3TX0A 3T01A 1E1ZP 2W5XA 4FDIA 1ALHA 2ZKTA 5AJ9A 4LR2A 2GA3A 1ELXA 5LRNA 1FSUA 4KM4A 3SZZA 1KH7A 2GLQA 1SHNA 1SHQA 5K4PA 2W5TA 2QZUA 3DPCA 1N2LA 3IGZB 5DLWA 1AJAA 4UPLA 1EQJA 5L0EA 3M8YA 1ZEBA 1KHJA 3NKPA 4LQYA 5DLVA 4GTWA 4ZGAA 4LRCA 3CMRA 4UPHA 5INHA 3MK0A 3NVLA 1URBA 4UOPA 3MK2A 3WAVA 1EJJA 4QAXA 1ED8A 2W5WA 1KHNA 3T00A 1KH5A 3WAXA 2XRGA 3NKMA 4B56A 2X98A 1O99A 4LRBA 3WAWA 2GSNA 2ANHA 4UORA 3BDGA 3IGYB 4FDJA 1K7HA 5IJSA 5L0BA 5IJQA 1AUKA 5LIAA 3E2DA 1AJCA 4KAYA 3UN5A 4MIVA 3Q3QA 5GOVA 4ZG9A 1URAA 3MK1A 4ZG6A 2RH6A 3B5QA 5DLTA
chains in the Genus database with same CATH topology
1EW2A 5TJ3A 4YR1A 1ED9A 1EW9A 3LXQA 1HDHA 3M8WA 1KHLA 3NKOA 4CXUA 4LR8A 4CYSA 2G9YA 4ZG7A 1EI6A 1HJKA 4KAVA 1ZEFA 1ELYA 3TG0A 5HRTA 2IUCB 1O98A 1KH9A 4TN0A 4LRAA 5LRMA 2GSOA 1ELZA 3UNYA 1E2SP 1Y7AA 5EGHA 1ALKA 3WAYA 1N2KA 2XR9A 3OT9A 3DYCA 2D1GA 4CXSA 2W8SA 3NKQA 4UPKA 3NKNA 2VQRA 2W5QA 3UN2A 4N7TA 3BDHA 1AJBA 4GTXA 1E33P 4NWXA 1ALJA 5EGEA 4UOOA 1KH4A 3M8ZA 1Y6VA 4LRFA 4CYRA 1B8JA 1KHKA 1E3CP 3BDFA 3IDDA 4NWJA 4MY4A 3SZYA 3WBHA 5C66A 1P49A 1ANIA 4LR9A 5GRRA 3M7VA 3TWZA 3UO0A 4MHXA 1AJDA 4LR7A 1ANJA 4CXKA 2IFYA 2W5RA 4KJDA 4LREA 1HQAA 3UN3A 1EW8A 1ZEDA 3ED4A 5L0KA 3KD8A 2W8DA 2IUCA 3T02A 2GSUA 4UPIA 1ALIA 5KXAA 3BDGB 3NKRA 4GTYA 3A52A 4LRDA 5LQQA 4GTZA 4KJGA 2W5SA 2W5VA 3TX0A 3T01A 1E1ZP 2W5XA 4FDIA 1ALHA 2ZKTA 5AJ9A 4LR2A 2GA3A 1ELXA 5LRNA 1FSUA 4KM4A 3SZZA 1KH7A 2GLQA 1SHNA 1SHQA 5K4PA 2W5TA 2QZUA 3DPCA 1N2LA 3IGZB 5DLWA 1AJAA 4UPLA 1EQJA 5L0EA 3M8YA 1ZEBA 1KHJA 3NKPA 4LQYA 5DLVA 4GTWA 4ZGAA 4LRCA 3CMRA 4UPHA 5INHA 3MK0A 3NVLA 1URBA 4UOPA 3MK2A 3WAVA 1EJJA 4QAXA 1ED8A 2W5WA 1KHNA 3T00A 1KH5A 3WAXA 2XRGA 3NKMA 4B56A 2X98A 1O99A 4LRBA 3WAWA 2GSNA 2ANHA 4UORA 3BDGA 3IGYB 4FDJA 1K7HA 5IJSA 5L0BA 5IJQA 1AUKA 5LIAA 3E2DA 1AJCA 4KAYA 3UN5A 4MIVA 3Q3QA 5GOVA 4ZG9A 1URAA 3MK1A 4ZG6A 2RH6A 3B5QA 5DLTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EW2 A;  5TJ3 A;  4YR1 A;  1ED9 A;  1EW9 A;  3LXQ A;  1HDH A;  3M8W A;  1KHL A;  3NKO A;  4CXU A;  4LR8 A;  4CYS A;  2G9Y A;  4ZG7 A;  1EI6 A;  1HJK A;  4KAV A;  1ZEF A;  1ELY A;  3TG0 A;  5HRT A;  2IUC B;  1O98 A;  1KH9 A;  4TN0 A;  4LRA A;  5LRM A;  2GSO A;  1ELZ A;  3UNY A;  1E2S P;  1Y7A A;  5EGH A;  1ALK A;  3WAY A;  1N2K A;  2XR9 A;  3OT9 A;  3DYC A;  2D1G A;  4CXS A;  2W8S A;  3NKQ A;  4UPK A;  3NKN A;  2VQR A;  2W5Q A;  3UN2 A;  4N7T A;  3BDH A;  1AJB A;  4GTX A;  1E33 P;  4NWX A;  1ALJ A;  5EGE A;  4UOO A;  1KH4 A;  3M8Z A;  1Y6V A;  4LRF A;  4CYR A;  1B8J A;  1KHK A;  1E3C P;  3BDF A;  3IDD A;  4NWJ A;  4MY4 A;  3SZY A;  3WBH A;  5C66 A;  1P49 A;  1ANI A;  4LR9 A;  5GRR A;  3M7V A;  3TWZ A;  3UO0 A;  4MHX A;  1AJD A;  4LR7 A;  1ANJ A;  4CXK A;  2IFY A;  2W5R A;  4KJD A;  4LRE A;  1HQA A;  3UN3 A;  1EW8 A;  1ZED A;  3ED4 A;  5L0K A;  3KD8 A;  2W8D A;  2IUC A;  3T02 A;  2GSU A;  4UPI A;  1ALI A;  5KXA A;  3BDG B;  3NKR A;  4GTY A;  3A52 A;  4LRD A;  5LQQ A;  4GTZ A;  4KJG A;  2W5S A;  2W5V A;  3TX0 A;  3T01 A;  1E1Z P;  2W5X A;  4FDI A;  1ALH A;  2ZKT A;  5AJ9 A;  4LR2 A;  2GA3 A;  1ELX A;  5LRN A;  1FSU A;  4KM4 A;  3SZZ A;  1KH7 A;  2GLQ A;  1SHN A;  1SHQ A;  5K4P A;  2W5T A;  2QZU A;  3DPC A;  1N2L A;  3IGZ B;  5DLW A;  1AJA A;  4UPL A;  1EQJ A;  5L0E A;  3M8Y A;  1ZEB A;  1KHJ A;  3NKP A;  4LQY A;  5DLV A;  4GTW A;  4ZGA A;  4LRC A;  3CMR A;  4UPH A;  5INH A;  3MK0 A;  3NVL A;  1URB A;  4UOP A;  3MK2 A;  3WAV A;  1EJJ A;  4QAX A;  1ED8 A;  2W5W A;  1KHN A;  3T00 A;  1KH5 A;  3WAX A;  2XRG A;  3NKM A;  4B56 A;  2X98 A;  1O99 A;  4LRB A;  3WAW A;  2GSN A;  2ANH A;  4UOR A;  3BDG A;  3IGY B;  4FDJ A;  1K7H A;  5IJS A;  5L0B A;  5IJQ A;  1AUK A;  5LIA A;  3E2D A;  1AJC A;  4KAY A;  3UN5 A;  4MIV A;  3Q3Q A;  5GOV A;  4ZG9 A;  1URA A;  3MK1 A;  4ZG6 A;  2RH6 A;  3B5Q A;  5DLT A; 
#chains in the Genus database with same CATH topology
 1EW2 A;  5TJ3 A;  4YR1 A;  1ED9 A;  1EW9 A;  3LXQ A;  1HDH A;  3M8W A;  1KHL A;  3NKO A;  4CXU A;  4LR8 A;  4CYS A;  2G9Y A;  4ZG7 A;  1EI6 A;  1HJK A;  4KAV A;  1ZEF A;  1ELY A;  3TG0 A;  5HRT A;  2IUC B;  1O98 A;  1KH9 A;  4TN0 A;  4LRA A;  5LRM A;  2GSO A;  1ELZ A;  3UNY A;  1E2S P;  1Y7A A;  5EGH A;  1ALK A;  3WAY A;  1N2K A;  2XR9 A;  3OT9 A;  3DYC A;  2D1G A;  4CXS A;  2W8S A;  3NKQ A;  4UPK A;  3NKN A;  2VQR A;  2W5Q A;  3UN2 A;  4N7T A;  3BDH A;  1AJB A;  4GTX A;  1E33 P;  4NWX A;  1ALJ A;  5EGE A;  4UOO A;  1KH4 A;  3M8Z A;  1Y6V A;  4LRF A;  4CYR A;  1B8J A;  1KHK A;  1E3C P;  3BDF A;  3IDD A;  4NWJ A;  4MY4 A;  3SZY A;  3WBH A;  5C66 A;  1P49 A;  1ANI A;  4LR9 A;  5GRR A;  3M7V A;  3TWZ A;  3UO0 A;  4MHX A;  1AJD A;  4LR7 A;  1ANJ A;  4CXK A;  2IFY A;  2W5R A;  4KJD A;  4LRE A;  1HQA A;  3UN3 A;  1EW8 A;  1ZED A;  3ED4 A;  5L0K A;  3KD8 A;  2W8D A;  2IUC A;  3T02 A;  2GSU A;  4UPI A;  1ALI A;  5KXA A;  3BDG B;  3NKR A;  4GTY A;  3A52 A;  4LRD A;  5LQQ A;  4GTZ A;  4KJG A;  2W5S A;  2W5V A;  3TX0 A;  3T01 A;  1E1Z P;  2W5X A;  4FDI A;  1ALH A;  2ZKT A;  5AJ9 A;  4LR2 A;  2GA3 A;  1ELX A;  5LRN A;  1FSU A;  4KM4 A;  3SZZ A;  1KH7 A;  2GLQ A;  1SHN A;  1SHQ A;  5K4P A;  2W5T A;  2QZU A;  3DPC A;  1N2L A;  3IGZ B;  5DLW A;  1AJA A;  4UPL A;  1EQJ A;  5L0E A;  3M8Y A;  1ZEB A;  1KHJ A;  3NKP A;  4LQY A;  5DLV A;  4GTW A;  4ZGA A;  4LRC A;  3CMR A;  4UPH A;  5INH A;  3MK0 A;  3NVL A;  1URB A;  4UOP A;  3MK2 A;  3WAV A;  1EJJ A;  4QAX A;  1ED8 A;  2W5W A;  1KHN A;  3T00 A;  1KH5 A;  3WAX A;  2XRG A;  3NKM A;  4B56 A;  2X98 A;  1O99 A;  4LRB A;  3WAW A;  2GSN A;  2ANH A;  4UOR A;  3BDG A;  3IGY B;  4FDJ A;  1K7H A;  5IJS A;  5L0B A;  5IJQ A;  1AUK A;  5LIA A;  3E2D A;  1AJC A;  4KAY A;  3UN5 A;  4MIV A;  3Q3Q A;  5GOV A;  4ZG9 A;  1URA A;  3MK1 A;  4ZG6 A;  2RH6 A;  3B5Q A;  5DLT A; 
#chains in the Genus database with same CATH homology
 1EW2 A;  5TJ3 A;  4YR1 A;  1ED9 A;  1EW9 A;  3LXQ A;  1HDH A;  3M8W A;  1KHL A;  3NKO A;  4CXU A;  4LR8 A;  4CYS A;  2G9Y A;  4ZG7 A;  1EI6 A;  1HJK A;  4KAV A;  1ZEF A;  1ELY A;  3TG0 A;  5HRT A;  2IUC B;  1O98 A;  1KH9 A;  4TN0 A;  4LRA A;  5LRM A;  2GSO A;  1ELZ A;  3UNY A;  1E2S P;  1Y7A A;  5EGH A;  1ALK A;  3WAY A;  1N2K A;  2XR9 A;  3OT9 A;  3DYC A;  2D1G A;  4CXS A;  2W8S A;  3NKQ A;  4UPK A;  3NKN A;  2VQR A;  2W5Q A;  3UN2 A;  4N7T A;  3BDH A;  1AJB A;  4GTX A;  1E33 P;  4NWX A;  1ALJ A;  5EGE A;  4UOO A;  1KH4 A;  3M8Z A;  1Y6V A;  4LRF A;  4CYR A;  1B8J A;  1KHK A;  1E3C P;  3BDF A;  3IDD A;  4NWJ A;  4MY4 A;  3SZY A;  3WBH A;  5C66 A;  1P49 A;  1ANI A;  4LR9 A;  5GRR A;  3M7V A;  3TWZ A;  3UO0 A;  4MHX A;  1AJD A;  4LR7 A;  1ANJ A;  4CXK A;  2IFY A;  2W5R A;  4KJD A;  4LRE A;  1HQA A;  3UN3 A;  1EW8 A;  1ZED A;  3ED4 A;  5L0K A;  3KD8 A;  2W8D A;  2IUC A;  3T02 A;  2GSU A;  4UPI A;  1ALI A;  5KXA A;  3BDG B;  3NKR A;  4GTY A;  3A52 A;  4LRD A;  5LQQ A;  4GTZ A;  4KJG A;  2W5S A;  2W5V A;  3TX0 A;  3T01 A;  1E1Z P;  2W5X A;  4FDI A;  1ALH A;  2ZKT A;  5AJ9 A;  4LR2 A;  2GA3 A;  1ELX A;  5LRN A;  1FSU A;  4KM4 A;  3SZZ A;  1KH7 A;  2GLQ A;  1SHN A;  1SHQ A;  5K4P A;  2W5T A;  2QZU A;  3DPC A;  1N2L A;  3IGZ B;  5DLW A;  1AJA A;  4UPL A;  1EQJ A;  5L0E A;  3M8Y A;  1ZEB A;  1KHJ A;  3NKP A;  4LQY A;  5DLV A;  4GTW A;  4ZGA A;  4LRC A;  3CMR A;  4UPH A;  5INH A;  3MK0 A;  3NVL A;  1URB A;  4UOP A;  3MK2 A;  3WAV A;  1EJJ A;  4QAX A;  1ED8 A;  2W5W A;  1KHN A;  3T00 A;  1KH5 A;  3WAX A;  2XRG A;  3NKM A;  4B56 A;  2X98 A;  1O99 A;  4LRB A;  3WAW A;  2GSN A;  2ANH A;  4UOR A;  3BDG A;  3IGY B;  4FDJ A;  1K7H A;  5IJS A;  5L0B A;  5IJQ A;  1AUK A;  5LIA A;  3E2D A;  1AJC A;  4KAY A;  3UN5 A;  4MIV A;  3Q3Q A;  5GOV A;  4ZG9 A;  1URA A;  3MK1 A;  4ZG6 A;  2RH6 A;  3B5Q A;  5DLT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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