1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase (alkaline phosphatase)
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
5GRRA 3NKMA 1URBA 3SZZA 5L0BA 3MK1A 2G9YA 4UPLA 3NKOA 5TJ3A 5HRTA 1E1ZP 5GOVA 3NKPA 3IDDA 2W5RA 5DLWA 1N2KA 4LR7A 2GA3A 5L0KA 4ZG7A 5INHA 5LRMA 4UPHA 1EW8A 1AJBA 3T01A 3WAYA 4N7TA 3M7VA 1KHJA 3BDGB 1HDHA 4QAXA 3BDFA 1AJAA 4NWXA 3WBHA 3NKNA 5LIAA 1O99A 1KHKA 1ELZA 4GTXA 3CMRA 2W8SA 1SHNA 3UN2A 3IGZB 4LRBA 3NKRA 2RH6A 2GSNA 4ZG6A 4LR8A 1E33P 4LQYA 4MHXA 1HQAA 3WAVA 1Y7AA 3NKQA 5IJSA 1ED9A 2QZUA 1ZEBA 2ANHA 2W5QA 3B5QA 3IGYB 3MK0A 4FDJA 4GTWA 4KJGA 1K7HA 4MY4A 4UORA 5LQQA 2W5WA 3SZYA 5C66A 2XRGA 3E2DA 4CXKA 1KHNA 4MIVA 4CYRA 3T00A 2W5TA 3DPCA 4ZG9A 3LXQA 1ALHA 4GTZA 1B8JA 4LRCA 1E2SP 1ANIA 1ELXA 3T02A 4UOPA 2W5XA 4YR1A 1AUKA 1KH7A 1EJJA 2IUCB 3BDGA 3WAXA 3TWZA 3DYCA 2VQRA 3NVLA 3A52A 4UPKA 1KH5A 1E3CP 2W8DA 4NWJA 3OT9A 3TX0A 4KAVA 3UO0A 1ZEDA 4LR9A 2W5SA 3M8ZA 3WAWA 3Q3QA 5DLVA 5IJQA 2IFYA 4UOOA 3M8YA 1URAA 2IUCA 4LR2A 4B56A 4KJDA 5KXAA 2X98A 4KM4A 4UPIA 4GTYA 5AJ9A 4KAYA 4LRAA 1P49A 1ELYA 4CXUA 3BDHA 1Y6VA 3TG0A 3MK2A 2XR9A 2D1GA 1ZEFA 1KH9A 3UN5A 5DLTA 1O98A 1AJCA 5K4PA 1KH4A 1EW2A 5L0EA 2GSUA 4LREA 5EGEA 2GSOA 1SHQA 3UNYA 5EGHA 4LRDA 2GLQA 1FSUA 4CXSA 3KD8A 4FDIA 1EI6A 4LRFA 1ALKA 3ED4A 4TN0A 1ED8A 3UN3A 4CYSA 1AJDA 2W5VA 3M8WA 1ALJA 1ANJA 1EW9A 1HJKA 1N2LA 1ALIA 1KHLA 5LRNA 4ZGAA 2ZKTA 1EQJA
chains in the Genus database with same CATH superfamily
5GRRA 3NKMA 1URBA 3SZZA 5L0BA 3MK1A 2G9YA 4UPLA 3NKOA 5TJ3A 5HRTA 1E1ZP 5GOVA 3NKPA 3IDDA 2W5RA 5DLWA 1N2KA 4LR7A 2GA3A 5L0KA 4ZG7A 5INHA 5LRMA 4UPHA 1EW8A 1AJBA 3T01A 3WAYA 4N7TA 3M7VA 1KHJA 3BDGB 1HDHA 4QAXA 3BDFA 1AJAA 4NWXA 3WBHA 3NKNA 5LIAA 1O99A 1KHKA 1ELZA 4GTXA 3CMRA 2W8SA 1SHNA 3UN2A 3IGZB 4LRBA 3NKRA 2RH6A 2GSNA 4ZG6A 4LR8A 1E33P 4LQYA 4MHXA 1HQAA 3WAVA 1Y7AA 3NKQA 5IJSA 1ED9A 2QZUA 1ZEBA 2ANHA 2W5QA 3B5QA 3IGYB 3MK0A 4FDJA 4GTWA 4KJGA 1K7HA 4MY4A 4UORA 5LQQA 2W5WA 3SZYA 5C66A 2XRGA 3E2DA 4CXKA 1KHNA 4MIVA 4CYRA 3T00A 2W5TA 3DPCA 4ZG9A 3LXQA 1ALHA 4GTZA 1B8JA 4LRCA 1E2SP 1ANIA 1ELXA 3T02A 4UOPA 2W5XA 4YR1A 1AUKA 1KH7A 1EJJA 2IUCB 3BDGA 3WAXA 3TWZA 3DYCA 2VQRA 3NVLA 3A52A 4UPKA 1KH5A 1E3CP 2W8DA 4NWJA 3OT9A 3TX0A 4KAVA 3UO0A 1ZEDA 4LR9A 2W5SA 3M8ZA 3WAWA 3Q3QA 5DLVA 5IJQA 2IFYA 4UOOA 3M8YA 1URAA 2IUCA 4LR2A 4B56A 4KJDA 5KXAA 2X98A 4KM4A 4UPIA 4GTYA 5AJ9A 4KAYA 4LRAA 1P49A 1ELYA 4CXUA 3BDHA 1Y6VA 3TG0A 3MK2A 2XR9A 2D1GA 1ZEFA 1KH9A 3UN5A 5DLTA 1O98A 1AJCA 5K4PA 1KH4A 1EW2A 5L0EA 2GSUA 4LREA 5EGEA 2GSOA 1SHQA 3UNYA 5EGHA 4LRDA 2GLQA 1FSUA 4CXSA 3KD8A 4FDIA 1EI6A 4LRFA 1ALKA 3ED4A 4TN0A 1ED8A 3UN3A 4CYSA 1AJDA 2W5VA 3M8WA 1ALJA 1ANJA 1EW9A 1HJKA 1N2LA 1ALIA 1KHLA 5LRNA 4ZGAA 2ZKTA 1EQJA
chains in the Genus database with same CATH topology
5GRRA 3NKMA 1URBA 3SZZA 5L0BA 3MK1A 2G9YA 4UPLA 3NKOA 5TJ3A 5HRTA 1E1ZP 5GOVA 3NKPA 3IDDA 2W5RA 5DLWA 1N2KA 4LR7A 2GA3A 5L0KA 4ZG7A 5INHA 5LRMA 4UPHA 1EW8A 1AJBA 3T01A 3WAYA 4N7TA 3M7VA 1KHJA 3BDGB 1HDHA 4QAXA 3BDFA 1AJAA 4NWXA 3WBHA 3NKNA 5LIAA 1O99A 1KHKA 1ELZA 4GTXA 3CMRA 2W8SA 1SHNA 3UN2A 3IGZB 4LRBA 3NKRA 2RH6A 2GSNA 4ZG6A 4LR8A 1E33P 4LQYA 4MHXA 1HQAA 3WAVA 1Y7AA 3NKQA 5IJSA 1ED9A 2QZUA 1ZEBA 2ANHA 2W5QA 3B5QA 3IGYB 3MK0A 4FDJA 4GTWA 4KJGA 1K7HA 4MY4A 4UORA 5LQQA 2W5WA 3SZYA 5C66A 2XRGA 3E2DA 4CXKA 1KHNA 4MIVA 4CYRA 3T00A 2W5TA 3DPCA 4ZG9A 3LXQA 1ALHA 4GTZA 1B8JA 4LRCA 1E2SP 1ANIA 1ELXA 3T02A 4UOPA 2W5XA 4YR1A 1AUKA 1KH7A 1EJJA 2IUCB 3BDGA 3WAXA 3TWZA 3DYCA 2VQRA 3NVLA 3A52A 4UPKA 1KH5A 1E3CP 2W8DA 4NWJA 3OT9A 3TX0A 4KAVA 3UO0A 1ZEDA 4LR9A 2W5SA 3M8ZA 3WAWA 3Q3QA 5DLVA 5IJQA 2IFYA 4UOOA 3M8YA 1URAA 2IUCA 4LR2A 4B56A 4KJDA 5KXAA 2X98A 4KM4A 4UPIA 4GTYA 5AJ9A 4KAYA 4LRAA 1P49A 1ELYA 4CXUA 3BDHA 1Y6VA 3TG0A 3MK2A 2XR9A 2D1GA 1ZEFA 1KH9A 3UN5A 5DLTA 1O98A 1AJCA 5K4PA 1KH4A 1EW2A 5L0EA 2GSUA 4LREA 5EGEA 2GSOA 1SHQA 3UNYA 5EGHA 4LRDA 2GLQA 1FSUA 4CXSA 3KD8A 4FDIA 1EI6A 4LRFA 1ALKA 3ED4A 4TN0A 1ED8A 3UN3A 4CYSA 1AJDA 2W5VA 3M8WA 1ALJA 1ANJA 1EW9A 1HJKA 1N2LA 1ALIA 1KHLA 5LRNA 4ZGAA 2ZKTA 1EQJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GRR A;  3NKM A;  1URB A;  3SZZ A;  5L0B A;  3MK1 A;  2G9Y A;  4UPL A;  3NKO A;  5TJ3 A;  5HRT A;  1E1Z P;  5GOV A;  3NKP A;  3IDD A;  2W5R A;  5DLW A;  1N2K A;  4LR7 A;  2GA3 A;  5L0K A;  4ZG7 A;  5INH A;  5LRM A;  4UPH A;  1EW8 A;  1AJB A;  3T01 A;  3WAY A;  4N7T A;  3M7V A;  1KHJ A;  3BDG B;  1HDH A;  4QAX A;  3BDF A;  1AJA A;  4NWX A;  3WBH A;  3NKN A;  5LIA A;  1O99 A;  1KHK A;  1ELZ A;  4GTX A;  3CMR A;  2W8S A;  1SHN A;  3UN2 A;  3IGZ B;  4LRB A;  3NKR A;  2RH6 A;  2GSN A;  4ZG6 A;  4LR8 A;  1E33 P;  4LQY A;  4MHX A;  1HQA A;  3WAV A;  1Y7A A;  3NKQ A;  5IJS A;  1ED9 A;  2QZU A;  1ZEB A;  2ANH A;  2W5Q A;  3B5Q A;  3IGY B;  3MK0 A;  4FDJ A;  4GTW A;  4KJG A;  1K7H A;  4MY4 A;  4UOR A;  5LQQ A;  2W5W A;  3SZY A;  5C66 A;  2XRG A;  3E2D A;  4CXK A;  1KHN A;  4MIV A;  4CYR A;  3T00 A;  2W5T A;  3DPC A;  4ZG9 A;  3LXQ A;  1ALH A;  4GTZ A;  1B8J A;  4LRC A;  1E2S P;  1ANI A;  1ELX A;  3T02 A;  4UOP A;  2W5X A;  4YR1 A;  1AUK A;  1KH7 A;  1EJJ A;  2IUC B;  3BDG A;  3WAX A;  3TWZ A;  3DYC A;  2VQR A;  3NVL A;  3A52 A;  4UPK A;  1KH5 A;  1E3C P;  2W8D A;  4NWJ A;  3OT9 A;  3TX0 A;  4KAV A;  3UO0 A;  1ZED A;  4LR9 A;  2W5S A;  3M8Z A;  3WAW A;  3Q3Q A;  5DLV A;  5IJQ A;  2IFY A;  4UOO A;  3M8Y A;  1URA A;  2IUC A;  4LR2 A;  4B56 A;  4KJD A;  5KXA A;  2X98 A;  4KM4 A;  4UPI A;  4GTY A;  5AJ9 A;  4KAY A;  4LRA A;  1P49 A;  1ELY A;  4CXU A;  3BDH A;  1Y6V A;  3TG0 A;  3MK2 A;  2XR9 A;  2D1G A;  1ZEF A;  1KH9 A;  3UN5 A;  5DLT A;  1O98 A;  1AJC A;  5K4P A;  1KH4 A;  1EW2 A;  5L0E A;  2GSU A;  4LRE A;  5EGE A;  2GSO A;  1SHQ A;  3UNY A;  5EGH A;  4LRD A;  2GLQ A;  1FSU A;  4CXS A;  3KD8 A;  4FDI A;  1EI6 A;  4LRF A;  1ALK A;  3ED4 A;  4TN0 A;  1ED8 A;  3UN3 A;  4CYS A;  1AJD A;  2W5V A;  3M8W A;  1ALJ A;  1ANJ A;  1EW9 A;  1HJK A;  1N2L A;  1ALI A;  1KHL A;  5LRN A;  4ZGA A;  2ZKT A;  1EQJ A; 
#chains in the Genus database with same CATH topology
 5GRR A;  3NKM A;  1URB A;  3SZZ A;  5L0B A;  3MK1 A;  2G9Y A;  4UPL A;  3NKO A;  5TJ3 A;  5HRT A;  1E1Z P;  5GOV A;  3NKP A;  3IDD A;  2W5R A;  5DLW A;  1N2K A;  4LR7 A;  2GA3 A;  5L0K A;  4ZG7 A;  5INH A;  5LRM A;  4UPH A;  1EW8 A;  1AJB A;  3T01 A;  3WAY A;  4N7T A;  3M7V A;  1KHJ A;  3BDG B;  1HDH A;  4QAX A;  3BDF A;  1AJA A;  4NWX A;  3WBH A;  3NKN A;  5LIA A;  1O99 A;  1KHK A;  1ELZ A;  4GTX A;  3CMR A;  2W8S A;  1SHN A;  3UN2 A;  3IGZ B;  4LRB A;  3NKR A;  2RH6 A;  2GSN A;  4ZG6 A;  4LR8 A;  1E33 P;  4LQY A;  4MHX A;  1HQA A;  3WAV A;  1Y7A A;  3NKQ A;  5IJS A;  1ED9 A;  2QZU A;  1ZEB A;  2ANH A;  2W5Q A;  3B5Q A;  3IGY B;  3MK0 A;  4FDJ A;  4GTW A;  4KJG A;  1K7H A;  4MY4 A;  4UOR A;  5LQQ A;  2W5W A;  3SZY A;  5C66 A;  2XRG A;  3E2D A;  4CXK A;  1KHN A;  4MIV A;  4CYR A;  3T00 A;  2W5T A;  3DPC A;  4ZG9 A;  3LXQ A;  1ALH A;  4GTZ A;  1B8J A;  4LRC A;  1E2S P;  1ANI A;  1ELX A;  3T02 A;  4UOP A;  2W5X A;  4YR1 A;  1AUK A;  1KH7 A;  1EJJ A;  2IUC B;  3BDG A;  3WAX A;  3TWZ A;  3DYC A;  2VQR A;  3NVL A;  3A52 A;  4UPK A;  1KH5 A;  1E3C P;  2W8D A;  4NWJ A;  3OT9 A;  3TX0 A;  4KAV A;  3UO0 A;  1ZED A;  4LR9 A;  2W5S A;  3M8Z A;  3WAW A;  3Q3Q A;  5DLV A;  5IJQ A;  2IFY A;  4UOO A;  3M8Y A;  1URA A;  2IUC A;  4LR2 A;  4B56 A;  4KJD A;  5KXA A;  2X98 A;  4KM4 A;  4UPI A;  4GTY A;  5AJ9 A;  4KAY A;  4LRA A;  1P49 A;  1ELY A;  4CXU A;  3BDH A;  1Y6V A;  3TG0 A;  3MK2 A;  2XR9 A;  2D1G A;  1ZEF A;  1KH9 A;  3UN5 A;  5DLT A;  1O98 A;  1AJC A;  5K4P A;  1KH4 A;  1EW2 A;  5L0E A;  2GSU A;  4LRE A;  5EGE A;  2GSO A;  1SHQ A;  3UNY A;  5EGH A;  4LRD A;  2GLQ A;  1FSU A;  4CXS A;  3KD8 A;  4FDI A;  1EI6 A;  4LRF A;  1ALK A;  3ED4 A;  4TN0 A;  1ED8 A;  3UN3 A;  4CYS A;  1AJD A;  2W5V A;  3M8W A;  1ALJ A;  1ANJ A;  1EW9 A;  1HJK A;  1N2L A;  1ALI A;  1KHL A;  5LRN A;  4ZGA A;  2ZKT A;  1EQJ A; 
#chains in the Genus database with same CATH homology
 5GRR A;  3NKM A;  1URB A;  3SZZ A;  5L0B A;  3MK1 A;  2G9Y A;  4UPL A;  3NKO A;  5TJ3 A;  5HRT A;  1E1Z P;  5GOV A;  3NKP A;  3IDD A;  2W5R A;  5DLW A;  1N2K A;  4LR7 A;  2GA3 A;  5L0K A;  4ZG7 A;  5INH A;  5LRM A;  4UPH A;  1EW8 A;  1AJB A;  3T01 A;  3WAY A;  4N7T A;  3M7V A;  1KHJ A;  3BDG B;  1HDH A;  4QAX A;  3BDF A;  1AJA A;  4NWX A;  3WBH A;  3NKN A;  5LIA A;  1O99 A;  1KHK A;  1ELZ A;  4GTX A;  3CMR A;  2W8S A;  1SHN A;  3UN2 A;  3IGZ B;  4LRB A;  3NKR A;  2RH6 A;  2GSN A;  4ZG6 A;  4LR8 A;  1E33 P;  4LQY A;  4MHX A;  1HQA A;  3WAV A;  1Y7A A;  3NKQ A;  5IJS A;  1ED9 A;  2QZU A;  1ZEB A;  2ANH A;  2W5Q A;  3B5Q A;  3IGY B;  3MK0 A;  4FDJ A;  4GTW A;  4KJG A;  1K7H A;  4MY4 A;  4UOR A;  5LQQ A;  2W5W A;  3SZY A;  5C66 A;  2XRG A;  3E2D A;  4CXK A;  1KHN A;  4MIV A;  4CYR A;  3T00 A;  2W5T A;  3DPC A;  4ZG9 A;  3LXQ A;  1ALH A;  4GTZ A;  1B8J A;  4LRC A;  1E2S P;  1ANI A;  1ELX A;  3T02 A;  4UOP A;  2W5X A;  4YR1 A;  1AUK A;  1KH7 A;  1EJJ A;  2IUC B;  3BDG A;  3WAX A;  3TWZ A;  3DYC A;  2VQR A;  3NVL A;  3A52 A;  4UPK A;  1KH5 A;  1E3C P;  2W8D A;  4NWJ A;  3OT9 A;  3TX0 A;  4KAV A;  3UO0 A;  1ZED A;  4LR9 A;  2W5S A;  3M8Z A;  3WAW A;  3Q3Q A;  5DLV A;  5IJQ A;  2IFY A;  4UOO A;  3M8Y A;  1URA A;  2IUC A;  4LR2 A;  4B56 A;  4KJD A;  5KXA A;  2X98 A;  4KM4 A;  4UPI A;  4GTY A;  5AJ9 A;  4KAY A;  4LRA A;  1P49 A;  1ELY A;  4CXU A;  3BDH A;  1Y6V A;  3TG0 A;  3MK2 A;  2XR9 A;  2D1G A;  1ZEF A;  1KH9 A;  3UN5 A;  5DLT A;  1O98 A;  1AJC A;  5K4P A;  1KH4 A;  1EW2 A;  5L0E A;  2GSU A;  4LRE A;  5EGE A;  2GSO A;  1SHQ A;  3UNY A;  5EGH A;  4LRD A;  2GLQ A;  1FSU A;  4CXS A;  3KD8 A;  4FDI A;  1EI6 A;  4LRF A;  1ALK A;  3ED4 A;  4TN0 A;  1ED8 A;  3UN3 A;  4CYS A;  1AJD A;  2W5V A;  3M8W A;  1ALJ A;  1ANJ A;  1EW9 A;  1HJK A;  1N2L A;  1ALI A;  1KHL A;  5LRN A;  4ZGA A;  2ZKT A;  1EQJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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