1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase (alkaline phosphatase)
molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
source organism Escherichia coli
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
4ZG7A 2RH6A 3TG0A 3E2DA 3IDDA 4UPIA 1EW2A 4KJGA 2ANHA 2GA3A 4KM4A 2W5TA 2XR9A 3BDGA 2X98A 3NVLA 3T00A 1HJKA 4ZGAA 4LR9A 1EJJA 2W5QA 3M7VA 2GSUA 1URAA 4LQYA 3UNYA 1ALHA 4UPHA 4FDIA 1ANIA 4UPLA 4N7TA 4MY4A 1K7HA 3NKRA 1AJCA 4LREA 4GTXA 2W8DA 5TJ3A 4KAVA 4NWXA 3WAVA 3A52A 3LXQA 1EQJA 2W5RA 4NWJA 4TN0A 3SZZA 5LIAA 2W5SA 1AJBA 2GSOA 4ZG9A 1E3CP 1KHLA 1AJAA 2W5VA 3BDHA 3SZYA 5HRTA 4CXUA 1KH5A 4GTYA 3TWZA 3IGZB 4ZG6A 5L0EA 2ZKTA 5EGEA 3UO0A 1N2KA 3BDGB 3NKNA 1O98A 1KH9A 4B56A 3WBHA 1ED8A 1KHNA 3OT9A 5IJQA 4UORA 2IUCA 5EGHA 4CYSA 4YR1A 3WAXA 1O99A 1ELYA 2W5XA 3UN5A 1P49A 1ED9A 2G9YA 3MK0A 2VQRA 4LR7A 1ELXA 1E1ZP 1KHJA 2IFYA 4LRAA 4CYRA 5DLWA 3MK2A 3KD8A 4CXKA 5L0KA 3DPCA 3M8ZA 3NKMA 3TX0A 2XRGA 4UOOA 5LRNA 3IGYB 4FDJA 1ALKA 1ANJA 4LRBA 1Y6VA 1KH4A 3T02A 4LRFA 3BDFA 1EW9A 2D1GA 1FSUA 5INHA 5C66A 4LRDA 4CXSA 3WAYA 3B5QA 1HDHA 1ALJA 5K4PA 2W8SA 2W5WA 4GTZA 1N2LA 3UN2A 1ZEFA 2IUCB 3NKPA 4MIVA 1SHNA 3MK1A 4GTWA 1HQAA 1B8JA 2QZUA 1ZEDA 1E2SP 1ALIA 5AJ9A 5IJSA 1E33P 1KHKA 4KJDA 4LR2A 5LQQA 1ZEBA 1AJDA 4QAXA 1EW8A 3ED4A 4LR8A 1URBA 3UN3A 5DLVA 1KH7A 3DYCA 4UOPA 5KXAA 1EI6A 2GSNA 5LRMA 5L0BA 4MHXA 2GLQA 5DLTA 3NKOA 3WAWA 5GOVA 1ELZA 1Y7AA 4LRCA 5GRRA 3NKQA 4KAYA 4UPKA 3Q3QA 3M8WA 3CMRA 3T01A 1AUKA 3M8YA 1SHQA
chains in the Genus database with same CATH superfamily
4ZG7A 2RH6A 3TG0A 3E2DA 3IDDA 4UPIA 1EW2A 4KJGA 2ANHA 2GA3A 4KM4A 2W5TA 2XR9A 3BDGA 2X98A 3NVLA 3T00A 1HJKA 4ZGAA 4LR9A 1EJJA 2W5QA 3M7VA 2GSUA 1URAA 4LQYA 3UNYA 1ALHA 4UPHA 4FDIA 1ANIA 4UPLA 4N7TA 4MY4A 1K7HA 3NKRA 1AJCA 4LREA 4GTXA 2W8DA 5TJ3A 4KAVA 4NWXA 3WAVA 3A52A 3LXQA 1EQJA 2W5RA 4NWJA 4TN0A 3SZZA 5LIAA 2W5SA 1AJBA 2GSOA 4ZG9A 1E3CP 1KHLA 1AJAA 2W5VA 3BDHA 3SZYA 5HRTA 4CXUA 1KH5A 4GTYA 3TWZA 3IGZB 4ZG6A 5L0EA 2ZKTA 5EGEA 3UO0A 1N2KA 3BDGB 3NKNA 1O98A 1KH9A 4B56A 3WBHA 1ED8A 1KHNA 3OT9A 5IJQA 4UORA 2IUCA 5EGHA 4CYSA 4YR1A 3WAXA 1O99A 1ELYA 2W5XA 3UN5A 1P49A 1ED9A 2G9YA 3MK0A 2VQRA 4LR7A 1ELXA 1E1ZP 1KHJA 2IFYA 4LRAA 4CYRA 5DLWA 3MK2A 3KD8A 4CXKA 5L0KA 3DPCA 3M8ZA 3NKMA 3TX0A 2XRGA 4UOOA 5LRNA 3IGYB 4FDJA 1ALKA 1ANJA 4LRBA 1Y6VA 1KH4A 3T02A 4LRFA 3BDFA 1EW9A 2D1GA 1FSUA 5INHA 5C66A 4LRDA 4CXSA 3WAYA 3B5QA 1HDHA 1ALJA 5K4PA 2W8SA 2W5WA 4GTZA 1N2LA 3UN2A 1ZEFA 2IUCB 3NKPA 4MIVA 1SHNA 3MK1A 4GTWA 1HQAA 1B8JA 2QZUA 1ZEDA 1E2SP 1ALIA 5AJ9A 5IJSA 1E33P 1KHKA 4KJDA 4LR2A 5LQQA 1ZEBA 1AJDA 4QAXA 1EW8A 3ED4A 4LR8A 1URBA 3UN3A 5DLVA 1KH7A 3DYCA 4UOPA 5KXAA 1EI6A 2GSNA 5LRMA 5L0BA 4MHXA 2GLQA 5DLTA 3NKOA 3WAWA 5GOVA 1ELZA 1Y7AA 4LRCA 5GRRA 3NKQA 4KAYA 4UPKA 3Q3QA 3M8WA 3CMRA 3T01A 1AUKA 3M8YA 1SHQA
chains in the Genus database with same CATH topology
4ZG7A 2RH6A 3TG0A 3E2DA 3IDDA 4UPIA 1EW2A 4KJGA 2ANHA 2GA3A 4KM4A 2W5TA 2XR9A 3BDGA 2X98A 3NVLA 3T00A 1HJKA 4ZGAA 4LR9A 1EJJA 2W5QA 3M7VA 2GSUA 1URAA 4LQYA 3UNYA 1ALHA 4UPHA 4FDIA 1ANIA 4UPLA 4N7TA 4MY4A 1K7HA 3NKRA 1AJCA 4LREA 4GTXA 2W8DA 5TJ3A 4KAVA 4NWXA 3WAVA 3A52A 3LXQA 1EQJA 2W5RA 4NWJA 4TN0A 3SZZA 5LIAA 2W5SA 1AJBA 2GSOA 4ZG9A 1E3CP 1KHLA 1AJAA 2W5VA 3BDHA 3SZYA 5HRTA 4CXUA 1KH5A 4GTYA 3TWZA 3IGZB 4ZG6A 5L0EA 2ZKTA 5EGEA 3UO0A 1N2KA 3BDGB 3NKNA 1O98A 1KH9A 4B56A 3WBHA 1ED8A 1KHNA 3OT9A 5IJQA 4UORA 2IUCA 5EGHA 4CYSA 4YR1A 3WAXA 1O99A 1ELYA 2W5XA 3UN5A 1P49A 1ED9A 2G9YA 3MK0A 2VQRA 4LR7A 1ELXA 1E1ZP 1KHJA 2IFYA 4LRAA 4CYRA 5DLWA 3MK2A 3KD8A 4CXKA 5L0KA 3DPCA 3M8ZA 3NKMA 3TX0A 2XRGA 4UOOA 5LRNA 3IGYB 4FDJA 1ALKA 1ANJA 4LRBA 1Y6VA 1KH4A 3T02A 4LRFA 3BDFA 1EW9A 2D1GA 1FSUA 5INHA 5C66A 4LRDA 4CXSA 3WAYA 3B5QA 1HDHA 1ALJA 5K4PA 2W8SA 2W5WA 4GTZA 1N2LA 3UN2A 1ZEFA 2IUCB 3NKPA 4MIVA 1SHNA 3MK1A 4GTWA 1HQAA 1B8JA 2QZUA 1ZEDA 1E2SP 1ALIA 5AJ9A 5IJSA 1E33P 1KHKA 4KJDA 4LR2A 5LQQA 1ZEBA 1AJDA 4QAXA 1EW8A 3ED4A 4LR8A 1URBA 3UN3A 5DLVA 1KH7A 3DYCA 4UOPA 5KXAA 1EI6A 2GSNA 5LRMA 5L0BA 4MHXA 2GLQA 5DLTA 3NKOA 3WAWA 5GOVA 1ELZA 1Y7AA 4LRCA 5GRRA 3NKQA 4KAYA 4UPKA 3Q3QA 3M8WA 3CMRA 3T01A 1AUKA 3M8YA 1SHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZG7 A;  2RH6 A;  3TG0 A;  3E2D A;  3IDD A;  4UPI A;  1EW2 A;  4KJG A;  2ANH A;  2GA3 A;  4KM4 A;  2W5T A;  2XR9 A;  3BDG A;  2X98 A;  3NVL A;  3T00 A;  1HJK A;  4ZGA A;  4LR9 A;  1EJJ A;  2W5Q A;  3M7V A;  2GSU A;  1URA A;  4LQY A;  3UNY A;  1ALH A;  4UPH A;  4FDI A;  1ANI A;  4UPL A;  4N7T A;  4MY4 A;  1K7H A;  3NKR A;  1AJC A;  4LRE A;  4GTX A;  2W8D A;  5TJ3 A;  4KAV A;  4NWX A;  3WAV A;  3A52 A;  3LXQ A;  1EQJ A;  2W5R A;  4NWJ A;  4TN0 A;  3SZZ A;  5LIA A;  2W5S A;  1AJB A;  2GSO A;  4ZG9 A;  1E3C P;  1KHL A;  1AJA A;  2W5V A;  3BDH A;  3SZY A;  5HRT A;  4CXU A;  1KH5 A;  4GTY A;  3TWZ A;  3IGZ B;  4ZG6 A;  5L0E A;  2ZKT A;  5EGE A;  3UO0 A;  1N2K A;  3BDG B;  3NKN A;  1O98 A;  1KH9 A;  4B56 A;  3WBH A;  1ED8 A;  1KHN A;  3OT9 A;  5IJQ A;  4UOR A;  2IUC A;  5EGH A;  4CYS A;  4YR1 A;  3WAX A;  1O99 A;  1ELY A;  2W5X A;  3UN5 A;  1P49 A;  1ED9 A;  2G9Y A;  3MK0 A;  2VQR A;  4LR7 A;  1ELX A;  1E1Z P;  1KHJ A;  2IFY A;  4LRA A;  4CYR A;  5DLW A;  3MK2 A;  3KD8 A;  4CXK A;  5L0K A;  3DPC A;  3M8Z A;  3NKM A;  3TX0 A;  2XRG A;  4UOO A;  5LRN A;  3IGY B;  4FDJ A;  1ALK A;  1ANJ A;  4LRB A;  1Y6V A;  1KH4 A;  3T02 A;  4LRF A;  3BDF A;  1EW9 A;  2D1G A;  1FSU A;  5INH A;  5C66 A;  4LRD A;  4CXS A;  3WAY A;  3B5Q A;  1HDH A;  1ALJ A;  5K4P A;  2W8S A;  2W5W A;  4GTZ A;  1N2L A;  3UN2 A;  1ZEF A;  2IUC B;  3NKP A;  4MIV A;  1SHN A;  3MK1 A;  4GTW A;  1HQA A;  1B8J A;  2QZU A;  1ZED A;  1E2S P;  1ALI A;  5AJ9 A;  5IJS A;  1E33 P;  1KHK A;  4KJD A;  4LR2 A;  5LQQ A;  1ZEB A;  1AJD A;  4QAX A;  1EW8 A;  3ED4 A;  4LR8 A;  1URB A;  3UN3 A;  5DLV A;  1KH7 A;  3DYC A;  4UOP A;  5KXA A;  1EI6 A;  2GSN A;  5LRM A;  5L0B A;  4MHX A;  2GLQ A;  5DLT A;  3NKO A;  3WAW A;  5GOV A;  1ELZ A;  1Y7A A;  4LRC A;  5GRR A;  3NKQ A;  4KAY A;  4UPK A;  3Q3Q A;  3M8W A;  3CMR A;  3T01 A;  1AUK A;  3M8Y A;  1SHQ A; 
#chains in the Genus database with same CATH topology
 4ZG7 A;  2RH6 A;  3TG0 A;  3E2D A;  3IDD A;  4UPI A;  1EW2 A;  4KJG A;  2ANH A;  2GA3 A;  4KM4 A;  2W5T A;  2XR9 A;  3BDG A;  2X98 A;  3NVL A;  3T00 A;  1HJK A;  4ZGA A;  4LR9 A;  1EJJ A;  2W5Q A;  3M7V A;  2GSU A;  1URA A;  4LQY A;  3UNY A;  1ALH A;  4UPH A;  4FDI A;  1ANI A;  4UPL A;  4N7T A;  4MY4 A;  1K7H A;  3NKR A;  1AJC A;  4LRE A;  4GTX A;  2W8D A;  5TJ3 A;  4KAV A;  4NWX A;  3WAV A;  3A52 A;  3LXQ A;  1EQJ A;  2W5R A;  4NWJ A;  4TN0 A;  3SZZ A;  5LIA A;  2W5S A;  1AJB A;  2GSO A;  4ZG9 A;  1E3C P;  1KHL A;  1AJA A;  2W5V A;  3BDH A;  3SZY A;  5HRT A;  4CXU A;  1KH5 A;  4GTY A;  3TWZ A;  3IGZ B;  4ZG6 A;  5L0E A;  2ZKT A;  5EGE A;  3UO0 A;  1N2K A;  3BDG B;  3NKN A;  1O98 A;  1KH9 A;  4B56 A;  3WBH A;  1ED8 A;  1KHN A;  3OT9 A;  5IJQ A;  4UOR A;  2IUC A;  5EGH A;  4CYS A;  4YR1 A;  3WAX A;  1O99 A;  1ELY A;  2W5X A;  3UN5 A;  1P49 A;  1ED9 A;  2G9Y A;  3MK0 A;  2VQR A;  4LR7 A;  1ELX A;  1E1Z P;  1KHJ A;  2IFY A;  4LRA A;  4CYR A;  5DLW A;  3MK2 A;  3KD8 A;  4CXK A;  5L0K A;  3DPC A;  3M8Z A;  3NKM A;  3TX0 A;  2XRG A;  4UOO A;  5LRN A;  3IGY B;  4FDJ A;  1ALK A;  1ANJ A;  4LRB A;  1Y6V A;  1KH4 A;  3T02 A;  4LRF A;  3BDF A;  1EW9 A;  2D1G A;  1FSU A;  5INH A;  5C66 A;  4LRD A;  4CXS A;  3WAY A;  3B5Q A;  1HDH A;  1ALJ A;  5K4P A;  2W8S A;  2W5W A;  4GTZ A;  1N2L A;  3UN2 A;  1ZEF A;  2IUC B;  3NKP A;  4MIV A;  1SHN A;  3MK1 A;  4GTW A;  1HQA A;  1B8J A;  2QZU A;  1ZED A;  1E2S P;  1ALI A;  5AJ9 A;  5IJS A;  1E33 P;  1KHK A;  4KJD A;  4LR2 A;  5LQQ A;  1ZEB A;  1AJD A;  4QAX A;  1EW8 A;  3ED4 A;  4LR8 A;  1URB A;  3UN3 A;  5DLV A;  1KH7 A;  3DYC A;  4UOP A;  5KXA A;  1EI6 A;  2GSN A;  5LRM A;  5L0B A;  4MHX A;  2GLQ A;  5DLT A;  3NKO A;  3WAW A;  5GOV A;  1ELZ A;  1Y7A A;  4LRC A;  5GRR A;  3NKQ A;  4KAY A;  4UPK A;  3Q3Q A;  3M8W A;  3CMR A;  3T01 A;  1AUK A;  3M8Y A;  1SHQ A; 
#chains in the Genus database with same CATH homology
 4ZG7 A;  2RH6 A;  3TG0 A;  3E2D A;  3IDD A;  4UPI A;  1EW2 A;  4KJG A;  2ANH A;  2GA3 A;  4KM4 A;  2W5T A;  2XR9 A;  3BDG A;  2X98 A;  3NVL A;  3T00 A;  1HJK A;  4ZGA A;  4LR9 A;  1EJJ A;  2W5Q A;  3M7V A;  2GSU A;  1URA A;  4LQY A;  3UNY A;  1ALH A;  4UPH A;  4FDI A;  1ANI A;  4UPL A;  4N7T A;  4MY4 A;  1K7H A;  3NKR A;  1AJC A;  4LRE A;  4GTX A;  2W8D A;  5TJ3 A;  4KAV A;  4NWX A;  3WAV A;  3A52 A;  3LXQ A;  1EQJ A;  2W5R A;  4NWJ A;  4TN0 A;  3SZZ A;  5LIA A;  2W5S A;  1AJB A;  2GSO A;  4ZG9 A;  1E3C P;  1KHL A;  1AJA A;  2W5V A;  3BDH A;  3SZY A;  5HRT A;  4CXU A;  1KH5 A;  4GTY A;  3TWZ A;  3IGZ B;  4ZG6 A;  5L0E A;  2ZKT A;  5EGE A;  3UO0 A;  1N2K A;  3BDG B;  3NKN A;  1O98 A;  1KH9 A;  4B56 A;  3WBH A;  1ED8 A;  1KHN A;  3OT9 A;  5IJQ A;  4UOR A;  2IUC A;  5EGH A;  4CYS A;  4YR1 A;  3WAX A;  1O99 A;  1ELY A;  2W5X A;  3UN5 A;  1P49 A;  1ED9 A;  2G9Y A;  3MK0 A;  2VQR A;  4LR7 A;  1ELX A;  1E1Z P;  1KHJ A;  2IFY A;  4LRA A;  4CYR A;  5DLW A;  3MK2 A;  3KD8 A;  4CXK A;  5L0K A;  3DPC A;  3M8Z A;  3NKM A;  3TX0 A;  2XRG A;  4UOO A;  5LRN A;  3IGY B;  4FDJ A;  1ALK A;  1ANJ A;  4LRB A;  1Y6V A;  1KH4 A;  3T02 A;  4LRF A;  3BDF A;  1EW9 A;  2D1G A;  1FSU A;  5INH A;  5C66 A;  4LRD A;  4CXS A;  3WAY A;  3B5Q A;  1HDH A;  1ALJ A;  5K4P A;  2W8S A;  2W5W A;  4GTZ A;  1N2L A;  3UN2 A;  1ZEF A;  2IUC B;  3NKP A;  4MIV A;  1SHN A;  3MK1 A;  4GTW A;  1HQA A;  1B8J A;  2QZU A;  1ZED A;  1E2S P;  1ALI A;  5AJ9 A;  5IJS A;  1E33 P;  1KHK A;  4KJD A;  4LR2 A;  5LQQ A;  1ZEB A;  1AJD A;  4QAX A;  1EW8 A;  3ED4 A;  4LR8 A;  1URB A;  3UN3 A;  5DLV A;  1KH7 A;  3DYC A;  4UOP A;  5KXA A;  1EI6 A;  2GSN A;  5LRM A;  5L0B A;  4MHX A;  2GLQ A;  5DLT A;  3NKO A;  3WAW A;  5GOV A;  1ELZ A;  1Y7A A;  4LRC A;  5GRR A;  3NKQ A;  4KAY A;  4UPK A;  3Q3Q A;  3M8W A;  3CMR A;  3T01 A;  1AUK A;  3M8Y A;  1SHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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