1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase (alkaline phosphatase)
molecule keywords ALKALINE PHOSPHATASE
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
5DLWA 5K4PA 1N2LA 2W5TA 1KH7A 4KAYA 5DLTA 2IFYA 3MK1A 2GA3A 1B8JA 4MY4A 3IGYB 1AJAA 3OT9A 5DLVA 1EW9A 3LXQA 2VQRA 2ANHA 2W5WA 2W5RA 4CXKA 4LR9A 3TWZA 4LRBA 4LRCA 1SHQA 3IDDA 1EI6A 1P49A 3M8YA 3NKRA 4ZG6A 3SZYA 1ALHA 1ZEBA 3BDHA 4KAVA 4UPKA 3WAYA 3NKNA 3MK2A 5HRTA 3CMRA 4N7TA 1AJDA 4FDIA 4CXUA 1E1ZP 4LRFA 1KHJA 3WBHA 3BDGB 4TN0A 4YR1A 3UNYA 5LIAA 4LR7A 3IGZB 1KHNA 1URAA 4ZG9A 4LRAA 1ZEDA 3T01A 1URBA 5INHA 1SHNA 4KM4A 1K7HA 1ZEFA 1Y7AA 2D1GA 5EGEA 1O98A 3Q3QA 3WAWA 1ALJA 2W5VA 1FSUA 1KH9A 2X98A 4LRDA 3T02A 3SZZA 1ELYA 1KHKA 3T00A 1Y6VA 2W8SA 4UPHA 1E3CP 4LREA 3NKMA 4QAXA 4GTWA 2XR9A 1HDHA 1EW8A 1HQAA 3UN5A 5TJ3A 2W8DA 3B5QA 4KJGA 2IUCB 4UOPA 4UPLA 3E2DA 1O99A 1E2SP 1EJJA 5AJ9A 1ALIA 2W5XA 2GSNA 3BDFA 3TX0A 1ED8A 1ED9A 2G9YA 4UPIA 4CYRA 5C66A 1E33P 1KH5A 1ELXA 5LRMA 4FDJA 4LR8A 4ZGAA 3WAVA 1ANJA 3DYCA 1EW2A 1ANIA 2XRGA 5IJSA 3UN2A 4CXSA 2GSOA 4CYSA 4LR2A 3BDGA 4MIVA 4NWXA 5EGHA 5L0KA 3NVLA 4MHXA 3UO0A 5L0BA 3WAXA 3UN3A 3NKPA 1KHLA 2W5SA 3NKQA 4ZG7A 3MK0A 4NWJA 5L0EA 5LQQA 1HJKA 3M8ZA 2IUCA 3NKOA 4UOOA 1ELZA 2RH6A 2GLQA 5GRRA 3M8WA 4KJDA 1AJCA 2ZKTA 2W5QA 3A52A 4LQYA 1N2KA 1ALKA 5LRNA 4B56A 1AJBA 2QZUA 1KH4A 2GSUA 4GTYA 3KD8A 4GTXA 4UORA 5IJQA 3M7VA 3ED4A 5KXAA 3TG0A 1AUKA 4GTZA 5GOVA 1EQJA 3DPCA
chains in the Genus database with same CATH superfamily
5DLWA 5K4PA 1N2LA 2W5TA 1KH7A 4KAYA 5DLTA 2IFYA 3MK1A 2GA3A 1B8JA 4MY4A 3IGYB 1AJAA 3OT9A 5DLVA 1EW9A 3LXQA 2VQRA 2ANHA 2W5WA 2W5RA 4CXKA 4LR9A 3TWZA 4LRBA 4LRCA 1SHQA 3IDDA 1EI6A 1P49A 3M8YA 3NKRA 4ZG6A 3SZYA 1ALHA 1ZEBA 3BDHA 4KAVA 4UPKA 3WAYA 3NKNA 3MK2A 5HRTA 3CMRA 4N7TA 1AJDA 4FDIA 4CXUA 1E1ZP 4LRFA 1KHJA 3WBHA 3BDGB 4TN0A 4YR1A 3UNYA 5LIAA 4LR7A 3IGZB 1KHNA 1URAA 4ZG9A 4LRAA 1ZEDA 3T01A 1URBA 5INHA 1SHNA 4KM4A 1K7HA 1ZEFA 1Y7AA 2D1GA 5EGEA 1O98A 3Q3QA 3WAWA 1ALJA 2W5VA 1FSUA 1KH9A 2X98A 4LRDA 3T02A 3SZZA 1ELYA 1KHKA 3T00A 1Y6VA 2W8SA 4UPHA 1E3CP 4LREA 3NKMA 4QAXA 4GTWA 2XR9A 1HDHA 1EW8A 1HQAA 3UN5A 5TJ3A 2W8DA 3B5QA 4KJGA 2IUCB 4UOPA 4UPLA 3E2DA 1O99A 1E2SP 1EJJA 5AJ9A 1ALIA 2W5XA 2GSNA 3BDFA 3TX0A 1ED8A 1ED9A 2G9YA 4UPIA 4CYRA 5C66A 1E33P 1KH5A 1ELXA 5LRMA 4FDJA 4LR8A 4ZGAA 3WAVA 1ANJA 3DYCA 1EW2A 1ANIA 2XRGA 5IJSA 3UN2A 4CXSA 2GSOA 4CYSA 4LR2A 3BDGA 4MIVA 4NWXA 5EGHA 5L0KA 3NVLA 4MHXA 3UO0A 5L0BA 3WAXA 3UN3A 3NKPA 1KHLA 2W5SA 3NKQA 4ZG7A 3MK0A 4NWJA 5L0EA 5LQQA 1HJKA 3M8ZA 2IUCA 3NKOA 4UOOA 1ELZA 2RH6A 2GLQA 5GRRA 3M8WA 4KJDA 1AJCA 2ZKTA 2W5QA 3A52A 4LQYA 1N2KA 1ALKA 5LRNA 4B56A 1AJBA 2QZUA 1KH4A 2GSUA 4GTYA 3KD8A 4GTXA 4UORA 5IJQA 3M7VA 3ED4A 5KXAA 3TG0A 1AUKA 4GTZA 5GOVA 1EQJA 3DPCA
chains in the Genus database with same CATH topology
5DLWA 5K4PA 1N2LA 2W5TA 1KH7A 4KAYA 5DLTA 2IFYA 3MK1A 2GA3A 1B8JA 4MY4A 3IGYB 1AJAA 3OT9A 5DLVA 1EW9A 3LXQA 2VQRA 2ANHA 2W5WA 2W5RA 4CXKA 4LR9A 3TWZA 4LRBA 4LRCA 1SHQA 3IDDA 1EI6A 1P49A 3M8YA 3NKRA 4ZG6A 3SZYA 1ALHA 1ZEBA 3BDHA 4KAVA 4UPKA 3WAYA 3NKNA 3MK2A 5HRTA 3CMRA 4N7TA 1AJDA 4FDIA 4CXUA 1E1ZP 4LRFA 1KHJA 3WBHA 3BDGB 4TN0A 4YR1A 3UNYA 5LIAA 4LR7A 3IGZB 1KHNA 1URAA 4ZG9A 4LRAA 1ZEDA 3T01A 1URBA 5INHA 1SHNA 4KM4A 1K7HA 1ZEFA 1Y7AA 2D1GA 5EGEA 1O98A 3Q3QA 3WAWA 1ALJA 2W5VA 1FSUA 1KH9A 2X98A 4LRDA 3T02A 3SZZA 1ELYA 1KHKA 3T00A 1Y6VA 2W8SA 4UPHA 1E3CP 4LREA 3NKMA 4QAXA 4GTWA 2XR9A 1HDHA 1EW8A 1HQAA 3UN5A 5TJ3A 2W8DA 3B5QA 4KJGA 2IUCB 4UOPA 4UPLA 3E2DA 1O99A 1E2SP 1EJJA 5AJ9A 1ALIA 2W5XA 2GSNA 3BDFA 3TX0A 1ED8A 1ED9A 2G9YA 4UPIA 4CYRA 5C66A 1E33P 1KH5A 1ELXA 5LRMA 4FDJA 4LR8A 4ZGAA 3WAVA 1ANJA 3DYCA 1EW2A 1ANIA 2XRGA 5IJSA 3UN2A 4CXSA 2GSOA 4CYSA 4LR2A 3BDGA 4MIVA 4NWXA 5EGHA 5L0KA 3NVLA 4MHXA 3UO0A 5L0BA 3WAXA 3UN3A 3NKPA 1KHLA 2W5SA 3NKQA 4ZG7A 3MK0A 4NWJA 5L0EA 5LQQA 1HJKA 3M8ZA 2IUCA 3NKOA 4UOOA 1ELZA 2RH6A 2GLQA 5GRRA 3M8WA 4KJDA 1AJCA 2ZKTA 2W5QA 3A52A 4LQYA 1N2KA 1ALKA 5LRNA 4B56A 1AJBA 2QZUA 1KH4A 2GSUA 4GTYA 3KD8A 4GTXA 4UORA 5IJQA 3M7VA 3ED4A 5KXAA 3TG0A 1AUKA 4GTZA 5GOVA 1EQJA 3DPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DLW A;  5K4P A;  1N2L A;  2W5T A;  1KH7 A;  4KAY A;  5DLT A;  2IFY A;  3MK1 A;  2GA3 A;  1B8J A;  4MY4 A;  3IGY B;  1AJA A;  3OT9 A;  5DLV A;  1EW9 A;  3LXQ A;  2VQR A;  2ANH A;  2W5W A;  2W5R A;  4CXK A;  4LR9 A;  3TWZ A;  4LRB A;  4LRC A;  1SHQ A;  3IDD A;  1EI6 A;  1P49 A;  3M8Y A;  3NKR A;  4ZG6 A;  3SZY A;  1ALH A;  1ZEB A;  3BDH A;  4KAV A;  4UPK A;  3WAY A;  3NKN A;  3MK2 A;  5HRT A;  3CMR A;  4N7T A;  1AJD A;  4FDI A;  4CXU A;  1E1Z P;  4LRF A;  1KHJ A;  3WBH A;  3BDG B;  4TN0 A;  4YR1 A;  3UNY A;  5LIA A;  4LR7 A;  3IGZ B;  1KHN A;  1URA A;  4ZG9 A;  4LRA A;  1ZED A;  3T01 A;  1URB A;  5INH A;  1SHN A;  4KM4 A;  1K7H A;  1ZEF A;  1Y7A A;  2D1G A;  5EGE A;  1O98 A;  3Q3Q A;  3WAW A;  1ALJ A;  2W5V A;  1FSU A;  1KH9 A;  2X98 A;  4LRD A;  3T02 A;  3SZZ A;  1ELY A;  1KHK A;  3T00 A;  1Y6V A;  2W8S A;  4UPH A;  1E3C P;  4LRE A;  3NKM A;  4QAX A;  4GTW A;  2XR9 A;  1HDH A;  1EW8 A;  1HQA A;  3UN5 A;  5TJ3 A;  2W8D A;  3B5Q A;  4KJG A;  2IUC B;  4UOP A;  4UPL A;  3E2D A;  1O99 A;  1E2S P;  1EJJ A;  5AJ9 A;  1ALI A;  2W5X A;  2GSN A;  3BDF A;  3TX0 A;  1ED8 A;  1ED9 A;  2G9Y A;  4UPI A;  4CYR A;  5C66 A;  1E33 P;  1KH5 A;  1ELX A;  5LRM A;  4FDJ A;  4LR8 A;  4ZGA A;  3WAV A;  1ANJ A;  3DYC A;  1EW2 A;  1ANI A;  2XRG A;  5IJS A;  3UN2 A;  4CXS A;  2GSO A;  4CYS A;  4LR2 A;  3BDG A;  4MIV A;  4NWX A;  5EGH A;  5L0K A;  3NVL A;  4MHX A;  3UO0 A;  5L0B A;  3WAX A;  3UN3 A;  3NKP A;  1KHL A;  2W5S A;  3NKQ A;  4ZG7 A;  3MK0 A;  4NWJ A;  5L0E A;  5LQQ A;  1HJK A;  3M8Z A;  2IUC A;  3NKO A;  4UOO A;  1ELZ A;  2RH6 A;  2GLQ A;  5GRR A;  3M8W A;  4KJD A;  1AJC A;  2ZKT A;  2W5Q A;  3A52 A;  4LQY A;  1N2K A;  1ALK A;  5LRN A;  4B56 A;  1AJB A;  2QZU A;  1KH4 A;  2GSU A;  4GTY A;  3KD8 A;  4GTX A;  4UOR A;  5IJQ A;  3M7V A;  3ED4 A;  5KXA A;  3TG0 A;  1AUK A;  4GTZ A;  5GOV A;  1EQJ A;  3DPC A; 
#chains in the Genus database with same CATH topology
 5DLW A;  5K4P A;  1N2L A;  2W5T A;  1KH7 A;  4KAY A;  5DLT A;  2IFY A;  3MK1 A;  2GA3 A;  1B8J A;  4MY4 A;  3IGY B;  1AJA A;  3OT9 A;  5DLV A;  1EW9 A;  3LXQ A;  2VQR A;  2ANH A;  2W5W A;  2W5R A;  4CXK A;  4LR9 A;  3TWZ A;  4LRB A;  4LRC A;  1SHQ A;  3IDD A;  1EI6 A;  1P49 A;  3M8Y A;  3NKR A;  4ZG6 A;  3SZY A;  1ALH A;  1ZEB A;  3BDH A;  4KAV A;  4UPK A;  3WAY A;  3NKN A;  3MK2 A;  5HRT A;  3CMR A;  4N7T A;  1AJD A;  4FDI A;  4CXU A;  1E1Z P;  4LRF A;  1KHJ A;  3WBH A;  3BDG B;  4TN0 A;  4YR1 A;  3UNY A;  5LIA A;  4LR7 A;  3IGZ B;  1KHN A;  1URA A;  4ZG9 A;  4LRA A;  1ZED A;  3T01 A;  1URB A;  5INH A;  1SHN A;  4KM4 A;  1K7H A;  1ZEF A;  1Y7A A;  2D1G A;  5EGE A;  1O98 A;  3Q3Q A;  3WAW A;  1ALJ A;  2W5V A;  1FSU A;  1KH9 A;  2X98 A;  4LRD A;  3T02 A;  3SZZ A;  1ELY A;  1KHK A;  3T00 A;  1Y6V A;  2W8S A;  4UPH A;  1E3C P;  4LRE A;  3NKM A;  4QAX A;  4GTW A;  2XR9 A;  1HDH A;  1EW8 A;  1HQA A;  3UN5 A;  5TJ3 A;  2W8D A;  3B5Q A;  4KJG A;  2IUC B;  4UOP A;  4UPL A;  3E2D A;  1O99 A;  1E2S P;  1EJJ A;  5AJ9 A;  1ALI A;  2W5X A;  2GSN A;  3BDF A;  3TX0 A;  1ED8 A;  1ED9 A;  2G9Y A;  4UPI A;  4CYR A;  5C66 A;  1E33 P;  1KH5 A;  1ELX A;  5LRM A;  4FDJ A;  4LR8 A;  4ZGA A;  3WAV A;  1ANJ A;  3DYC A;  1EW2 A;  1ANI A;  2XRG A;  5IJS A;  3UN2 A;  4CXS A;  2GSO A;  4CYS A;  4LR2 A;  3BDG A;  4MIV A;  4NWX A;  5EGH A;  5L0K A;  3NVL A;  4MHX A;  3UO0 A;  5L0B A;  3WAX A;  3UN3 A;  3NKP A;  1KHL A;  2W5S A;  3NKQ A;  4ZG7 A;  3MK0 A;  4NWJ A;  5L0E A;  5LQQ A;  1HJK A;  3M8Z A;  2IUC A;  3NKO A;  4UOO A;  1ELZ A;  2RH6 A;  2GLQ A;  5GRR A;  3M8W A;  4KJD A;  1AJC A;  2ZKT A;  2W5Q A;  3A52 A;  4LQY A;  1N2K A;  1ALK A;  5LRN A;  4B56 A;  1AJB A;  2QZU A;  1KH4 A;  2GSU A;  4GTY A;  3KD8 A;  4GTX A;  4UOR A;  5IJQ A;  3M7V A;  3ED4 A;  5KXA A;  3TG0 A;  1AUK A;  4GTZ A;  5GOV A;  1EQJ A;  3DPC A; 
#chains in the Genus database with same CATH homology
 5DLW A;  5K4P A;  1N2L A;  2W5T A;  1KH7 A;  4KAY A;  5DLT A;  2IFY A;  3MK1 A;  2GA3 A;  1B8J A;  4MY4 A;  3IGY B;  1AJA A;  3OT9 A;  5DLV A;  1EW9 A;  3LXQ A;  2VQR A;  2ANH A;  2W5W A;  2W5R A;  4CXK A;  4LR9 A;  3TWZ A;  4LRB A;  4LRC A;  1SHQ A;  3IDD A;  1EI6 A;  1P49 A;  3M8Y A;  3NKR A;  4ZG6 A;  3SZY A;  1ALH A;  1ZEB A;  3BDH A;  4KAV A;  4UPK A;  3WAY A;  3NKN A;  3MK2 A;  5HRT A;  3CMR A;  4N7T A;  1AJD A;  4FDI A;  4CXU A;  1E1Z P;  4LRF A;  1KHJ A;  3WBH A;  3BDG B;  4TN0 A;  4YR1 A;  3UNY A;  5LIA A;  4LR7 A;  3IGZ B;  1KHN A;  1URA A;  4ZG9 A;  4LRA A;  1ZED A;  3T01 A;  1URB A;  5INH A;  1SHN A;  4KM4 A;  1K7H A;  1ZEF A;  1Y7A A;  2D1G A;  5EGE A;  1O98 A;  3Q3Q A;  3WAW A;  1ALJ A;  2W5V A;  1FSU A;  1KH9 A;  2X98 A;  4LRD A;  3T02 A;  3SZZ A;  1ELY A;  1KHK A;  3T00 A;  1Y6V A;  2W8S A;  4UPH A;  1E3C P;  4LRE A;  3NKM A;  4QAX A;  4GTW A;  2XR9 A;  1HDH A;  1EW8 A;  1HQA A;  3UN5 A;  5TJ3 A;  2W8D A;  3B5Q A;  4KJG A;  2IUC B;  4UOP A;  4UPL A;  3E2D A;  1O99 A;  1E2S P;  1EJJ A;  5AJ9 A;  1ALI A;  2W5X A;  2GSN A;  3BDF A;  3TX0 A;  1ED8 A;  1ED9 A;  2G9Y A;  4UPI A;  4CYR A;  5C66 A;  1E33 P;  1KH5 A;  1ELX A;  5LRM A;  4FDJ A;  4LR8 A;  4ZGA A;  3WAV A;  1ANJ A;  3DYC A;  1EW2 A;  1ANI A;  2XRG A;  5IJS A;  3UN2 A;  4CXS A;  2GSO A;  4CYS A;  4LR2 A;  3BDG A;  4MIV A;  4NWX A;  5EGH A;  5L0K A;  3NVL A;  4MHX A;  3UO0 A;  5L0B A;  3WAX A;  3UN3 A;  3NKP A;  1KHL A;  2W5S A;  3NKQ A;  4ZG7 A;  3MK0 A;  4NWJ A;  5L0E A;  5LQQ A;  1HJK A;  3M8Z A;  2IUC A;  3NKO A;  4UOO A;  1ELZ A;  2RH6 A;  2GLQ A;  5GRR A;  3M8W A;  4KJD A;  1AJC A;  2ZKT A;  2W5Q A;  3A52 A;  4LQY A;  1N2K A;  1ALK A;  5LRN A;  4B56 A;  1AJB A;  2QZU A;  1KH4 A;  2GSU A;  4GTY A;  3KD8 A;  4GTX A;  4UOR A;  5IJQ A;  3M7V A;  3ED4 A;  5KXA A;  3TG0 A;  1AUK A;  4GTZ A;  5GOV A;  1EQJ A;  3DPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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