1HQAA

Alkaline phosphatase (h412q)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEQTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of a mutant Escherichia coli alkaline phosphatase (His-412-->Gln) at one of the zinc binding sites.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase (alkaline phosphatase)
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-11-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1hqaA00
1AJCA 4KJGA 4NWXA 4FDIA 4CXUA 3M7VA 3UO0A 3B5QA 1N2LA 1P49A 4TN0A 4ZG9A 1HQAA 4CYRA 3TWZA 1EW9A 1KHKA 2W5RA 2W8SA 1FSUA 2X98A 4LRBA 3WAYA 3MK0A 4YR1A 4MHXA 2IFYA 1ZEBA 3DYCA 4LR9A 1ZEFA 4LR8A 1SHNA 2W5SA 4QAXA 2W8DA 1ANJA 2QZUA 4LRAA 2IUCB 1ALHA 5HRTA 4NWJA 3M8WA 5LRMA 5TJ3A 1E2SP 1EQJA 5IJSA 1KHJA 1KHNA 2W5QA 3T01A 4GTZA 1E1ZP 1ZEDA 3SZYA 4KAVA 4ZG7A 3SZZA 3KD8A 5L0KA 3E2DA 3A52A 5L0BA 1KH4A 3TG0A 3BDFA 3NKPA 3Q3QA 1HJKA 3BDHA 3UN5A 3LXQA 1ALJA 1AJAA 1SHQA 1Y6VA 3BDGB 1ALKA 4KJDA 1EW2A 3NKOA 1KH5A 3OT9A 4KM4A 2GSNA 5LIAA 4N7TA 3WAXA 3IGZB 2VQRA 2ANHA 5K4PA 4FDJA 2XRGA 4LREA 1EI6A 1KH9A 4LRFA 3DPCA 3IDDA 3TX0A 1N2KA 3WAVA 5DLTA 3T00A 1EJJA 2GSOA 4LQYA 3IGYB 4MIVA 1Y7AA 4KAYA 3WBHA 5EGEA 1ALIA 4LR2A 4UOOA 1AJBA 5AJ9A 4MY4A 2GA3A 3M8YA 2G9YA 1ELXA 5INHA 4CXKA 5EGHA 1O98A 5DLVA 1ED9A 4LRCA 1URBA 4GTYA 1K7HA 3NKMA 1B8JA 1EW8A 1KH7A 2W5XA 4UPLA 2W5TA 3NKQA 3MK2A 2XR9A 1E3CP 4ZGAA 1E33P 1ELZA 1KHLA 3M8ZA 3UNYA 4CYSA 2W5VA 3WAWA 1AUKA 1ED8A 4ZG6A 3NVLA 4LRDA 3CMRA 1HDHA 5L0EA 4B56A 3NKNA 1AJDA 3ED4A 4UPHA 1URAA 2W5WA 4GTXA 5LRNA 5C66A 4UPIA 5DLWA 3UN2A 3MK1A 4CXSA 2D1GA 4UOPA 1O99A 3T02A 3NKRA 4GTWA 5LQQA 4LR7A 1ELYA 4UPKA 5KXAA 3BDGA 2GSUA 1ANIA 5IJQA 3UN3A 2IUCA 2RH6A 5GOVA 5GRRA 2GLQA 2ZKTA 4UORA
chains in the Genus database with same CATH superfamily
1AJCA 4KJGA 4NWXA 4FDIA 4CXUA 3M7VA 3UO0A 3B5QA 1N2LA 1P49A 4TN0A 4ZG9A 1HQAA 4CYRA 3TWZA 1EW9A 1KHKA 2W5RA 2W8SA 1FSUA 2X98A 4LRBA 3WAYA 3MK0A 4YR1A 4MHXA 2IFYA 1ZEBA 3DYCA 4LR9A 1ZEFA 4LR8A 1SHNA 2W5SA 4QAXA 2W8DA 1ANJA 2QZUA 4LRAA 2IUCB 1ALHA 5HRTA 4NWJA 3M8WA 5LRMA 5TJ3A 1E2SP 1EQJA 5IJSA 1KHJA 1KHNA 2W5QA 3T01A 4GTZA 1E1ZP 1ZEDA 3SZYA 4KAVA 4ZG7A 3SZZA 3KD8A 5L0KA 3E2DA 3A52A 5L0BA 1KH4A 3TG0A 3BDFA 3NKPA 3Q3QA 1HJKA 3BDHA 3UN5A 3LXQA 1ALJA 1AJAA 1SHQA 1Y6VA 3BDGB 1ALKA 4KJDA 1EW2A 3NKOA 1KH5A 3OT9A 4KM4A 2GSNA 5LIAA 4N7TA 3WAXA 3IGZB 2VQRA 2ANHA 5K4PA 4FDJA 2XRGA 4LREA 1EI6A 1KH9A 4LRFA 3DPCA 3IDDA 3TX0A 1N2KA 3WAVA 5DLTA 3T00A 1EJJA 2GSOA 4LQYA 3IGYB 4MIVA 1Y7AA 4KAYA 3WBHA 5EGEA 1ALIA 4LR2A 4UOOA 1AJBA 5AJ9A 4MY4A 2GA3A 3M8YA 2G9YA 1ELXA 5INHA 4CXKA 5EGHA 1O98A 5DLVA 1ED9A 4LRCA 1URBA 4GTYA 1K7HA 3NKMA 1B8JA 1EW8A 1KH7A 2W5XA 4UPLA 2W5TA 3NKQA 3MK2A 2XR9A 1E3CP 4ZGAA 1E33P 1ELZA 1KHLA 3M8ZA 3UNYA 4CYSA 2W5VA 3WAWA 1AUKA 1ED8A 4ZG6A 3NVLA 4LRDA 3CMRA 1HDHA 5L0EA 4B56A 3NKNA 1AJDA 3ED4A 4UPHA 1URAA 2W5WA 4GTXA 5LRNA 5C66A 4UPIA 5DLWA 3UN2A 3MK1A 4CXSA 2D1GA 4UOPA 1O99A 3T02A 3NKRA 4GTWA 5LQQA 4LR7A 1ELYA 4UPKA 5KXAA 3BDGA 2GSUA 1ANIA 5IJQA 3UN3A 2IUCA 2RH6A 5GOVA 5GRRA 2GLQA 2ZKTA 4UORA
chains in the Genus database with same CATH topology
1AJCA 4KJGA 4NWXA 4FDIA 4CXUA 3M7VA 3UO0A 3B5QA 1N2LA 1P49A 4TN0A 4ZG9A 1HQAA 4CYRA 3TWZA 1EW9A 1KHKA 2W5RA 2W8SA 1FSUA 2X98A 4LRBA 3WAYA 3MK0A 4YR1A 4MHXA 2IFYA 1ZEBA 3DYCA 4LR9A 1ZEFA 4LR8A 1SHNA 2W5SA 4QAXA 2W8DA 1ANJA 2QZUA 4LRAA 2IUCB 1ALHA 5HRTA 4NWJA 3M8WA 5LRMA 5TJ3A 1E2SP 1EQJA 5IJSA 1KHJA 1KHNA 2W5QA 3T01A 4GTZA 1E1ZP 1ZEDA 3SZYA 4KAVA 4ZG7A 3SZZA 3KD8A 5L0KA 3E2DA 3A52A 5L0BA 1KH4A 3TG0A 3BDFA 3NKPA 3Q3QA 1HJKA 3BDHA 3UN5A 3LXQA 1ALJA 1AJAA 1SHQA 1Y6VA 3BDGB 1ALKA 4KJDA 1EW2A 3NKOA 1KH5A 3OT9A 4KM4A 2GSNA 5LIAA 4N7TA 3WAXA 3IGZB 2VQRA 2ANHA 5K4PA 4FDJA 2XRGA 4LREA 1EI6A 1KH9A 4LRFA 3DPCA 3IDDA 3TX0A 1N2KA 3WAVA 5DLTA 3T00A 1EJJA 2GSOA 4LQYA 3IGYB 4MIVA 1Y7AA 4KAYA 3WBHA 5EGEA 1ALIA 4LR2A 4UOOA 1AJBA 5AJ9A 4MY4A 2GA3A 3M8YA 2G9YA 1ELXA 5INHA 4CXKA 5EGHA 1O98A 5DLVA 1ED9A 4LRCA 1URBA 4GTYA 1K7HA 3NKMA 1B8JA 1EW8A 1KH7A 2W5XA 4UPLA 2W5TA 3NKQA 3MK2A 2XR9A 1E3CP 4ZGAA 1E33P 1ELZA 1KHLA 3M8ZA 3UNYA 4CYSA 2W5VA 3WAWA 1AUKA 1ED8A 4ZG6A 3NVLA 4LRDA 3CMRA 1HDHA 5L0EA 4B56A 3NKNA 1AJDA 3ED4A 4UPHA 1URAA 2W5WA 4GTXA 5LRNA 5C66A 4UPIA 5DLWA 3UN2A 3MK1A 4CXSA 2D1GA 4UOPA 1O99A 3T02A 3NKRA 4GTWA 5LQQA 4LR7A 1ELYA 4UPKA 5KXAA 3BDGA 2GSUA 1ANIA 5IJQA 3UN3A 2IUCA 2RH6A 5GOVA 5GRRA 2GLQA 2ZKTA 4UORA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJC A;  4KJG A;  4NWX A;  4FDI A;  4CXU A;  3M7V A;  3UO0 A;  3B5Q A;  1N2L A;  1P49 A;  4TN0 A;  4ZG9 A;  1HQA A;  4CYR A;  3TWZ A;  1EW9 A;  1KHK A;  2W5R A;  2W8S A;  1FSU A;  2X98 A;  4LRB A;  3WAY A;  3MK0 A;  4YR1 A;  4MHX A;  2IFY A;  1ZEB A;  3DYC A;  4LR9 A;  1ZEF A;  4LR8 A;  1SHN A;  2W5S A;  4QAX A;  2W8D A;  1ANJ A;  2QZU A;  4LRA A;  2IUC B;  1ALH A;  5HRT A;  4NWJ A;  3M8W A;  5LRM A;  5TJ3 A;  1E2S P;  1EQJ A;  5IJS A;  1KHJ A;  1KHN A;  2W5Q A;  3T01 A;  4GTZ A;  1E1Z P;  1ZED A;  3SZY A;  4KAV A;  4ZG7 A;  3SZZ A;  3KD8 A;  5L0K A;  3E2D A;  3A52 A;  5L0B A;  1KH4 A;  3TG0 A;  3BDF A;  3NKP A;  3Q3Q A;  1HJK A;  3BDH A;  3UN5 A;  3LXQ A;  1ALJ A;  1AJA A;  1SHQ A;  1Y6V A;  3BDG B;  1ALK A;  4KJD A;  1EW2 A;  3NKO A;  1KH5 A;  3OT9 A;  4KM4 A;  2GSN A;  5LIA A;  4N7T A;  3WAX A;  3IGZ B;  2VQR A;  2ANH A;  5K4P A;  4FDJ A;  2XRG A;  4LRE A;  1EI6 A;  1KH9 A;  4LRF A;  3DPC A;  3IDD A;  3TX0 A;  1N2K A;  3WAV A;  5DLT A;  3T00 A;  1EJJ A;  2GSO A;  4LQY A;  3IGY B;  4MIV A;  1Y7A A;  4KAY A;  3WBH A;  5EGE A;  1ALI A;  4LR2 A;  4UOO A;  1AJB A;  5AJ9 A;  4MY4 A;  2GA3 A;  3M8Y A;  2G9Y A;  1ELX A;  5INH A;  4CXK A;  5EGH A;  1O98 A;  5DLV A;  1ED9 A;  4LRC A;  1URB A;  4GTY A;  1K7H A;  3NKM A;  1B8J A;  1EW8 A;  1KH7 A;  2W5X A;  4UPL A;  2W5T A;  3NKQ A;  3MK2 A;  2XR9 A;  1E3C P;  4ZGA A;  1E33 P;  1ELZ A;  1KHL A;  3M8Z A;  3UNY A;  4CYS A;  2W5V A;  3WAW A;  1AUK A;  1ED8 A;  4ZG6 A;  3NVL A;  4LRD A;  3CMR A;  1HDH A;  5L0E A;  4B56 A;  3NKN A;  1AJD A;  3ED4 A;  4UPH A;  1URA A;  2W5W A;  4GTX A;  5LRN A;  5C66 A;  4UPI A;  5DLW A;  3UN2 A;  3MK1 A;  4CXS A;  2D1G A;  4UOP A;  1O99 A;  3T02 A;  3NKR A;  4GTW A;  5LQQ A;  4LR7 A;  1ELY A;  4UPK A;  5KXA A;  3BDG A;  2GSU A;  1ANI A;  5IJQ A;  3UN3 A;  2IUC A;  2RH6 A;  5GOV A;  5GRR A;  2GLQ A;  2ZKT A;  4UOR A; 
#chains in the Genus database with same CATH topology
 1AJC A;  4KJG A;  4NWX A;  4FDI A;  4CXU A;  3M7V A;  3UO0 A;  3B5Q A;  1N2L A;  1P49 A;  4TN0 A;  4ZG9 A;  1HQA A;  4CYR A;  3TWZ A;  1EW9 A;  1KHK A;  2W5R A;  2W8S A;  1FSU A;  2X98 A;  4LRB A;  3WAY A;  3MK0 A;  4YR1 A;  4MHX A;  2IFY A;  1ZEB A;  3DYC A;  4LR9 A;  1ZEF A;  4LR8 A;  1SHN A;  2W5S A;  4QAX A;  2W8D A;  1ANJ A;  2QZU A;  4LRA A;  2IUC B;  1ALH A;  5HRT A;  4NWJ A;  3M8W A;  5LRM A;  5TJ3 A;  1E2S P;  1EQJ A;  5IJS A;  1KHJ A;  1KHN A;  2W5Q A;  3T01 A;  4GTZ A;  1E1Z P;  1ZED A;  3SZY A;  4KAV A;  4ZG7 A;  3SZZ A;  3KD8 A;  5L0K A;  3E2D A;  3A52 A;  5L0B A;  1KH4 A;  3TG0 A;  3BDF A;  3NKP A;  3Q3Q A;  1HJK A;  3BDH A;  3UN5 A;  3LXQ A;  1ALJ A;  1AJA A;  1SHQ A;  1Y6V A;  3BDG B;  1ALK A;  4KJD A;  1EW2 A;  3NKO A;  1KH5 A;  3OT9 A;  4KM4 A;  2GSN A;  5LIA A;  4N7T A;  3WAX A;  3IGZ B;  2VQR A;  2ANH A;  5K4P A;  4FDJ A;  2XRG A;  4LRE A;  1EI6 A;  1KH9 A;  4LRF A;  3DPC A;  3IDD A;  3TX0 A;  1N2K A;  3WAV A;  5DLT A;  3T00 A;  1EJJ A;  2GSO A;  4LQY A;  3IGY B;  4MIV A;  1Y7A A;  4KAY A;  3WBH A;  5EGE A;  1ALI A;  4LR2 A;  4UOO A;  1AJB A;  5AJ9 A;  4MY4 A;  2GA3 A;  3M8Y A;  2G9Y A;  1ELX A;  5INH A;  4CXK A;  5EGH A;  1O98 A;  5DLV A;  1ED9 A;  4LRC A;  1URB A;  4GTY A;  1K7H A;  3NKM A;  1B8J A;  1EW8 A;  1KH7 A;  2W5X A;  4UPL A;  2W5T A;  3NKQ A;  3MK2 A;  2XR9 A;  1E3C P;  4ZGA A;  1E33 P;  1ELZ A;  1KHL A;  3M8Z A;  3UNY A;  4CYS A;  2W5V A;  3WAW A;  1AUK A;  1ED8 A;  4ZG6 A;  3NVL A;  4LRD A;  3CMR A;  1HDH A;  5L0E A;  4B56 A;  3NKN A;  1AJD A;  3ED4 A;  4UPH A;  1URA A;  2W5W A;  4GTX A;  5LRN A;  5C66 A;  4UPI A;  5DLW A;  3UN2 A;  3MK1 A;  4CXS A;  2D1G A;  4UOP A;  1O99 A;  3T02 A;  3NKR A;  4GTW A;  5LQQ A;  4LR7 A;  1ELY A;  4UPK A;  5KXA A;  3BDG A;  2GSU A;  1ANI A;  5IJQ A;  3UN3 A;  2IUC A;  2RH6 A;  5GOV A;  5GRR A;  2GLQ A;  2ZKT A;  4UOR A; 
#chains in the Genus database with same CATH homology
 1AJC A;  4KJG A;  4NWX A;  4FDI A;  4CXU A;  3M7V A;  3UO0 A;  3B5Q A;  1N2L A;  1P49 A;  4TN0 A;  4ZG9 A;  1HQA A;  4CYR A;  3TWZ A;  1EW9 A;  1KHK A;  2W5R A;  2W8S A;  1FSU A;  2X98 A;  4LRB A;  3WAY A;  3MK0 A;  4YR1 A;  4MHX A;  2IFY A;  1ZEB A;  3DYC A;  4LR9 A;  1ZEF A;  4LR8 A;  1SHN A;  2W5S A;  4QAX A;  2W8D A;  1ANJ A;  2QZU A;  4LRA A;  2IUC B;  1ALH A;  5HRT A;  4NWJ A;  3M8W A;  5LRM A;  5TJ3 A;  1E2S P;  1EQJ A;  5IJS A;  1KHJ A;  1KHN A;  2W5Q A;  3T01 A;  4GTZ A;  1E1Z P;  1ZED A;  3SZY A;  4KAV A;  4ZG7 A;  3SZZ A;  3KD8 A;  5L0K A;  3E2D A;  3A52 A;  5L0B A;  1KH4 A;  3TG0 A;  3BDF A;  3NKP A;  3Q3Q A;  1HJK A;  3BDH A;  3UN5 A;  3LXQ A;  1ALJ A;  1AJA A;  1SHQ A;  1Y6V A;  3BDG B;  1ALK A;  4KJD A;  1EW2 A;  3NKO A;  1KH5 A;  3OT9 A;  4KM4 A;  2GSN A;  5LIA A;  4N7T A;  3WAX A;  3IGZ B;  2VQR A;  2ANH A;  5K4P A;  4FDJ A;  2XRG A;  4LRE A;  1EI6 A;  1KH9 A;  4LRF A;  3DPC A;  3IDD A;  3TX0 A;  1N2K A;  3WAV A;  5DLT A;  3T00 A;  1EJJ A;  2GSO A;  4LQY A;  3IGY B;  4MIV A;  1Y7A A;  4KAY A;  3WBH A;  5EGE A;  1ALI A;  4LR2 A;  4UOO A;  1AJB A;  5AJ9 A;  4MY4 A;  2GA3 A;  3M8Y A;  2G9Y A;  1ELX A;  5INH A;  4CXK A;  5EGH A;  1O98 A;  5DLV A;  1ED9 A;  4LRC A;  1URB A;  4GTY A;  1K7H A;  3NKM A;  1B8J A;  1EW8 A;  1KH7 A;  2W5X A;  4UPL A;  2W5T A;  3NKQ A;  3MK2 A;  2XR9 A;  1E3C P;  4ZGA A;  1E33 P;  1ELZ A;  1KHL A;  3M8Z A;  3UNY A;  4CYS A;  2W5V A;  3WAW A;  1AUK A;  1ED8 A;  4ZG6 A;  3NVL A;  4LRD A;  3CMR A;  1HDH A;  5L0E A;  4B56 A;  3NKN A;  1AJD A;  3ED4 A;  4UPH A;  1URA A;  2W5W A;  4GTX A;  5LRN A;  5C66 A;  4UPI A;  5DLW A;  3UN2 A;  3MK1 A;  4CXS A;  2D1G A;  4UOP A;  1O99 A;  3T02 A;  3NKR A;  4GTW A;  5LQQ A;  4LR7 A;  1ELY A;  4UPK A;  5KXA A;  3BDG A;  2GSU A;  1ANI A;  5IJQ A;  3UN3 A;  2IUC A;  2RH6 A;  5GOV A;  5GRR A;  2GLQ A;  2ZKT A;  4UOR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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