1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
3UNYA 3WAVA 4UPIA 2XR9A 1EQJA 1ALIA 5L0KA 3BDHA 2RH6A 3M8ZA 4MHXA 5IJQA 3WAWA 3OT9A 1AJAA 1ED9A 1Y7AA 4CYSA 2W5VA 2X98A 3NVLA 2W5RA 1AJCA 5DLTA 1ZEFA 1HDHA 4FDJA 3BDGB 5EGHA 4UORA 4FDIA 3NKOA 3NKPA 5TJ3A 1EI6A 5LRMA 3WBHA 1KHLA 3CMRA 3NKNA 5K4PA 1E33P 5LQQA 1ALKA 2W5QA 4KJDA 2ANHA 4LR7A 4LREA 3M8WA 3IGZB 4MY4A 4GTXA 1AJBA 1B8JA 3E2DA 3TX0A 2W5SA 3UN3A 4KAYA 5LIAA 2IUCA 4LRAA 3ED4A 3SZZA 1E3CP 1KH7A 3T01A 5GOVA 4UPLA 3IGYB 3M7VA 4LR9A 5AJ9A 4B56A 4CYRA 4LRBA 5DLWA 4CXSA 5DLVA 1EW2A 4ZG7A 1Y6VA 4LR2A 4GTWA 1AJDA 4UOOA 2QZUA 3BDFA 3UN2A 4ZG6A 4CXKA 1ELZA 1ALJA 1AUKA 4KJGA 3UN5A 4ZGAA 4ZG9A 2W5TA 3MK0A 3B5QA 4LQYA 2IUCB 4UPHA 1O99A 3NKQA 1ED8A 2W8SA 1KH9A 1KH4A 3T00A 1HQAA 3SZYA 3KD8A 2W5XA 1FSUA 3NKMA 2G9YA 3Q3QA 1N2KA 2XRGA 3DPCA 4LRFA 4TN0A 1ANIA 3T02A 1N2LA 3TG0A 1EW8A 3M8YA 4LRDA 1KHKA 4N7TA 3WAYA 5GRRA 3DYCA 3A52A 1ANJA 2GLQA 5HRTA 2GA3A 1EW9A 1ELXA 1KHNA 4GTZA 4UPKA 4UOPA 1HJKA 4KAVA 4LRCA 5LRNA 2W5WA 5C66A 2ZKTA 1KHJA 5KXAA 4MIVA 2W8DA 2IFYA 1ZEBA 4CXUA 4GTYA 2GSUA 4KM4A 3WAXA 2D1GA 3TWZA 2GSNA 1E2SP 3IDDA 1SHQA 1URAA 1URBA 1SHNA 4YR1A 5L0EA 5L0BA 1ELYA 1E1ZP 2GSOA 3NKRA 3MK2A 2VQRA 4NWXA 3UO0A 4LR8A 1K7HA 4QAXA 5INHA 5EGEA 1EJJA 1ALHA 3MK1A 1O98A 1ZEDA 3LXQA 1P49A 3BDGA 1KH5A 5IJSA 4NWJA
chains in the Genus database with same CATH superfamily
3UNYA 3WAVA 4UPIA 2XR9A 1EQJA 1ALIA 5L0KA 3BDHA 2RH6A 3M8ZA 4MHXA 5IJQA 3WAWA 3OT9A 1AJAA 1ED9A 1Y7AA 4CYSA 2W5VA 2X98A 3NVLA 2W5RA 1AJCA 5DLTA 1ZEFA 1HDHA 4FDJA 3BDGB 5EGHA 4UORA 4FDIA 3NKOA 3NKPA 5TJ3A 1EI6A 5LRMA 3WBHA 1KHLA 3CMRA 3NKNA 5K4PA 1E33P 5LQQA 1ALKA 2W5QA 4KJDA 2ANHA 4LR7A 4LREA 3M8WA 3IGZB 4MY4A 4GTXA 1AJBA 1B8JA 3E2DA 3TX0A 2W5SA 3UN3A 4KAYA 5LIAA 2IUCA 4LRAA 3ED4A 3SZZA 1E3CP 1KH7A 3T01A 5GOVA 4UPLA 3IGYB 3M7VA 4LR9A 5AJ9A 4B56A 4CYRA 4LRBA 5DLWA 4CXSA 5DLVA 1EW2A 4ZG7A 1Y6VA 4LR2A 4GTWA 1AJDA 4UOOA 2QZUA 3BDFA 3UN2A 4ZG6A 4CXKA 1ELZA 1ALJA 1AUKA 4KJGA 3UN5A 4ZGAA 4ZG9A 2W5TA 3MK0A 3B5QA 4LQYA 2IUCB 4UPHA 1O99A 3NKQA 1ED8A 2W8SA 1KH9A 1KH4A 3T00A 1HQAA 3SZYA 3KD8A 2W5XA 1FSUA 3NKMA 2G9YA 3Q3QA 1N2KA 2XRGA 3DPCA 4LRFA 4TN0A 1ANIA 3T02A 1N2LA 3TG0A 1EW8A 3M8YA 4LRDA 1KHKA 4N7TA 3WAYA 5GRRA 3DYCA 3A52A 1ANJA 2GLQA 5HRTA 2GA3A 1EW9A 1ELXA 1KHNA 4GTZA 4UPKA 4UOPA 1HJKA 4KAVA 4LRCA 5LRNA 2W5WA 5C66A 2ZKTA 1KHJA 5KXAA 4MIVA 2W8DA 2IFYA 1ZEBA 4CXUA 4GTYA 2GSUA 4KM4A 3WAXA 2D1GA 3TWZA 2GSNA 1E2SP 3IDDA 1SHQA 1URAA 1URBA 1SHNA 4YR1A 5L0EA 5L0BA 1ELYA 1E1ZP 2GSOA 3NKRA 3MK2A 2VQRA 4NWXA 3UO0A 4LR8A 1K7HA 4QAXA 5INHA 5EGEA 1EJJA 1ALHA 3MK1A 1O98A 1ZEDA 3LXQA 1P49A 3BDGA 1KH5A 5IJSA 4NWJA
chains in the Genus database with same CATH topology
3UNYA 3WAVA 4UPIA 2XR9A 1EQJA 1ALIA 5L0KA 3BDHA 2RH6A 3M8ZA 4MHXA 5IJQA 3WAWA 3OT9A 1AJAA 1ED9A 1Y7AA 4CYSA 2W5VA 2X98A 3NVLA 2W5RA 1AJCA 5DLTA 1ZEFA 1HDHA 4FDJA 3BDGB 5EGHA 4UORA 4FDIA 3NKOA 3NKPA 5TJ3A 1EI6A 5LRMA 3WBHA 1KHLA 3CMRA 3NKNA 5K4PA 1E33P 5LQQA 1ALKA 2W5QA 4KJDA 2ANHA 4LR7A 4LREA 3M8WA 3IGZB 4MY4A 4GTXA 1AJBA 1B8JA 3E2DA 3TX0A 2W5SA 3UN3A 4KAYA 5LIAA 2IUCA 4LRAA 3ED4A 3SZZA 1E3CP 1KH7A 3T01A 5GOVA 4UPLA 3IGYB 3M7VA 4LR9A 5AJ9A 4B56A 4CYRA 4LRBA 5DLWA 4CXSA 5DLVA 1EW2A 4ZG7A 1Y6VA 4LR2A 4GTWA 1AJDA 4UOOA 2QZUA 3BDFA 3UN2A 4ZG6A 4CXKA 1ELZA 1ALJA 1AUKA 4KJGA 3UN5A 4ZGAA 4ZG9A 2W5TA 3MK0A 3B5QA 4LQYA 2IUCB 4UPHA 1O99A 3NKQA 1ED8A 2W8SA 1KH9A 1KH4A 3T00A 1HQAA 3SZYA 3KD8A 2W5XA 1FSUA 3NKMA 2G9YA 3Q3QA 1N2KA 2XRGA 3DPCA 4LRFA 4TN0A 1ANIA 3T02A 1N2LA 3TG0A 1EW8A 3M8YA 4LRDA 1KHKA 4N7TA 3WAYA 5GRRA 3DYCA 3A52A 1ANJA 2GLQA 5HRTA 2GA3A 1EW9A 1ELXA 1KHNA 4GTZA 4UPKA 4UOPA 1HJKA 4KAVA 4LRCA 5LRNA 2W5WA 5C66A 2ZKTA 1KHJA 5KXAA 4MIVA 2W8DA 2IFYA 1ZEBA 4CXUA 4GTYA 2GSUA 4KM4A 3WAXA 2D1GA 3TWZA 2GSNA 1E2SP 3IDDA 1SHQA 1URAA 1URBA 1SHNA 4YR1A 5L0EA 5L0BA 1ELYA 1E1ZP 2GSOA 3NKRA 3MK2A 2VQRA 4NWXA 3UO0A 4LR8A 1K7HA 4QAXA 5INHA 5EGEA 1EJJA 1ALHA 3MK1A 1O98A 1ZEDA 3LXQA 1P49A 3BDGA 1KH5A 5IJSA 4NWJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UNY A;  3WAV A;  4UPI A;  2XR9 A;  1EQJ A;  1ALI A;  5L0K A;  3BDH A;  2RH6 A;  3M8Z A;  4MHX A;  5IJQ A;  3WAW A;  3OT9 A;  1AJA A;  1ED9 A;  1Y7A A;  4CYS A;  2W5V A;  2X98 A;  3NVL A;  2W5R A;  1AJC A;  5DLT A;  1ZEF A;  1HDH A;  4FDJ A;  3BDG B;  5EGH A;  4UOR A;  4FDI A;  3NKO A;  3NKP A;  5TJ3 A;  1EI6 A;  5LRM A;  3WBH A;  1KHL A;  3CMR A;  3NKN A;  5K4P A;  1E33 P;  5LQQ A;  1ALK A;  2W5Q A;  4KJD A;  2ANH A;  4LR7 A;  4LRE A;  3M8W A;  3IGZ B;  4MY4 A;  4GTX A;  1AJB A;  1B8J A;  3E2D A;  3TX0 A;  2W5S A;  3UN3 A;  4KAY A;  5LIA A;  2IUC A;  4LRA A;  3ED4 A;  3SZZ A;  1E3C P;  1KH7 A;  3T01 A;  5GOV A;  4UPL A;  3IGY B;  3M7V A;  4LR9 A;  5AJ9 A;  4B56 A;  4CYR A;  4LRB A;  5DLW A;  4CXS A;  5DLV A;  1EW2 A;  4ZG7 A;  1Y6V A;  4LR2 A;  4GTW A;  1AJD A;  4UOO A;  2QZU A;  3BDF A;  3UN2 A;  4ZG6 A;  4CXK A;  1ELZ A;  1ALJ A;  1AUK A;  4KJG A;  3UN5 A;  4ZGA A;  4ZG9 A;  2W5T A;  3MK0 A;  3B5Q A;  4LQY A;  2IUC B;  4UPH A;  1O99 A;  3NKQ A;  1ED8 A;  2W8S A;  1KH9 A;  1KH4 A;  3T00 A;  1HQA A;  3SZY A;  3KD8 A;  2W5X A;  1FSU A;  3NKM A;  2G9Y A;  3Q3Q A;  1N2K A;  2XRG A;  3DPC A;  4LRF A;  4TN0 A;  1ANI A;  3T02 A;  1N2L A;  3TG0 A;  1EW8 A;  3M8Y A;  4LRD A;  1KHK A;  4N7T A;  3WAY A;  5GRR A;  3DYC A;  3A52 A;  1ANJ A;  2GLQ A;  5HRT A;  2GA3 A;  1EW9 A;  1ELX A;  1KHN A;  4GTZ A;  4UPK A;  4UOP A;  1HJK A;  4KAV A;  4LRC A;  5LRN A;  2W5W A;  5C66 A;  2ZKT A;  1KHJ A;  5KXA A;  4MIV A;  2W8D A;  2IFY A;  1ZEB A;  4CXU A;  4GTY A;  2GSU A;  4KM4 A;  3WAX A;  2D1G A;  3TWZ A;  2GSN A;  1E2S P;  3IDD A;  1SHQ A;  1URA A;  1URB A;  1SHN A;  4YR1 A;  5L0E A;  5L0B A;  1ELY A;  1E1Z P;  2GSO A;  3NKR A;  3MK2 A;  2VQR A;  4NWX A;  3UO0 A;  4LR8 A;  1K7H A;  4QAX A;  5INH A;  5EGE A;  1EJJ A;  1ALH A;  3MK1 A;  1O98 A;  1ZED A;  3LXQ A;  1P49 A;  3BDG A;  1KH5 A;  5IJS A;  4NWJ A; 
#chains in the Genus database with same CATH topology
 3UNY A;  3WAV A;  4UPI A;  2XR9 A;  1EQJ A;  1ALI A;  5L0K A;  3BDH A;  2RH6 A;  3M8Z A;  4MHX A;  5IJQ A;  3WAW A;  3OT9 A;  1AJA A;  1ED9 A;  1Y7A A;  4CYS A;  2W5V A;  2X98 A;  3NVL A;  2W5R A;  1AJC A;  5DLT A;  1ZEF A;  1HDH A;  4FDJ A;  3BDG B;  5EGH A;  4UOR A;  4FDI A;  3NKO A;  3NKP A;  5TJ3 A;  1EI6 A;  5LRM A;  3WBH A;  1KHL A;  3CMR A;  3NKN A;  5K4P A;  1E33 P;  5LQQ A;  1ALK A;  2W5Q A;  4KJD A;  2ANH A;  4LR7 A;  4LRE A;  3M8W A;  3IGZ B;  4MY4 A;  4GTX A;  1AJB A;  1B8J A;  3E2D A;  3TX0 A;  2W5S A;  3UN3 A;  4KAY A;  5LIA A;  2IUC A;  4LRA A;  3ED4 A;  3SZZ A;  1E3C P;  1KH7 A;  3T01 A;  5GOV A;  4UPL A;  3IGY B;  3M7V A;  4LR9 A;  5AJ9 A;  4B56 A;  4CYR A;  4LRB A;  5DLW A;  4CXS A;  5DLV A;  1EW2 A;  4ZG7 A;  1Y6V A;  4LR2 A;  4GTW A;  1AJD A;  4UOO A;  2QZU A;  3BDF A;  3UN2 A;  4ZG6 A;  4CXK A;  1ELZ A;  1ALJ A;  1AUK A;  4KJG A;  3UN5 A;  4ZGA A;  4ZG9 A;  2W5T A;  3MK0 A;  3B5Q A;  4LQY A;  2IUC B;  4UPH A;  1O99 A;  3NKQ A;  1ED8 A;  2W8S A;  1KH9 A;  1KH4 A;  3T00 A;  1HQA A;  3SZY A;  3KD8 A;  2W5X A;  1FSU A;  3NKM A;  2G9Y A;  3Q3Q A;  1N2K A;  2XRG A;  3DPC A;  4LRF A;  4TN0 A;  1ANI A;  3T02 A;  1N2L A;  3TG0 A;  1EW8 A;  3M8Y A;  4LRD A;  1KHK A;  4N7T A;  3WAY A;  5GRR A;  3DYC A;  3A52 A;  1ANJ A;  2GLQ A;  5HRT A;  2GA3 A;  1EW9 A;  1ELX A;  1KHN A;  4GTZ A;  4UPK A;  4UOP A;  1HJK A;  4KAV A;  4LRC A;  5LRN A;  2W5W A;  5C66 A;  2ZKT A;  1KHJ A;  5KXA A;  4MIV A;  2W8D A;  2IFY A;  1ZEB A;  4CXU A;  4GTY A;  2GSU A;  4KM4 A;  3WAX A;  2D1G A;  3TWZ A;  2GSN A;  1E2S P;  3IDD A;  1SHQ A;  1URA A;  1URB A;  1SHN A;  4YR1 A;  5L0E A;  5L0B A;  1ELY A;  1E1Z P;  2GSO A;  3NKR A;  3MK2 A;  2VQR A;  4NWX A;  3UO0 A;  4LR8 A;  1K7H A;  4QAX A;  5INH A;  5EGE A;  1EJJ A;  1ALH A;  3MK1 A;  1O98 A;  1ZED A;  3LXQ A;  1P49 A;  3BDG A;  1KH5 A;  5IJS A;  4NWJ A; 
#chains in the Genus database with same CATH homology
 3UNY A;  3WAV A;  4UPI A;  2XR9 A;  1EQJ A;  1ALI A;  5L0K A;  3BDH A;  2RH6 A;  3M8Z A;  4MHX A;  5IJQ A;  3WAW A;  3OT9 A;  1AJA A;  1ED9 A;  1Y7A A;  4CYS A;  2W5V A;  2X98 A;  3NVL A;  2W5R A;  1AJC A;  5DLT A;  1ZEF A;  1HDH A;  4FDJ A;  3BDG B;  5EGH A;  4UOR A;  4FDI A;  3NKO A;  3NKP A;  5TJ3 A;  1EI6 A;  5LRM A;  3WBH A;  1KHL A;  3CMR A;  3NKN A;  5K4P A;  1E33 P;  5LQQ A;  1ALK A;  2W5Q A;  4KJD A;  2ANH A;  4LR7 A;  4LRE A;  3M8W A;  3IGZ B;  4MY4 A;  4GTX A;  1AJB A;  1B8J A;  3E2D A;  3TX0 A;  2W5S A;  3UN3 A;  4KAY A;  5LIA A;  2IUC A;  4LRA A;  3ED4 A;  3SZZ A;  1E3C P;  1KH7 A;  3T01 A;  5GOV A;  4UPL A;  3IGY B;  3M7V A;  4LR9 A;  5AJ9 A;  4B56 A;  4CYR A;  4LRB A;  5DLW A;  4CXS A;  5DLV A;  1EW2 A;  4ZG7 A;  1Y6V A;  4LR2 A;  4GTW A;  1AJD A;  4UOO A;  2QZU A;  3BDF A;  3UN2 A;  4ZG6 A;  4CXK A;  1ELZ A;  1ALJ A;  1AUK A;  4KJG A;  3UN5 A;  4ZGA A;  4ZG9 A;  2W5T A;  3MK0 A;  3B5Q A;  4LQY A;  2IUC B;  4UPH A;  1O99 A;  3NKQ A;  1ED8 A;  2W8S A;  1KH9 A;  1KH4 A;  3T00 A;  1HQA A;  3SZY A;  3KD8 A;  2W5X A;  1FSU A;  3NKM A;  2G9Y A;  3Q3Q A;  1N2K A;  2XRG A;  3DPC A;  4LRF A;  4TN0 A;  1ANI A;  3T02 A;  1N2L A;  3TG0 A;  1EW8 A;  3M8Y A;  4LRD A;  1KHK A;  4N7T A;  3WAY A;  5GRR A;  3DYC A;  3A52 A;  1ANJ A;  2GLQ A;  5HRT A;  2GA3 A;  1EW9 A;  1ELX A;  1KHN A;  4GTZ A;  4UPK A;  4UOP A;  1HJK A;  4KAV A;  4LRC A;  5LRN A;  2W5W A;  5C66 A;  2ZKT A;  1KHJ A;  5KXA A;  4MIV A;  2W8D A;  2IFY A;  1ZEB A;  4CXU A;  4GTY A;  2GSU A;  4KM4 A;  3WAX A;  2D1G A;  3TWZ A;  2GSN A;  1E2S P;  3IDD A;  1SHQ A;  1URA A;  1URB A;  1SHN A;  4YR1 A;  5L0E A;  5L0B A;  1ELY A;  1E1Z P;  2GSO A;  3NKR A;  3MK2 A;  2VQR A;  4NWX A;  3UO0 A;  4LR8 A;  1K7H A;  4QAX A;  5INH A;  5EGE A;  1EJJ A;  1ALH A;  3MK1 A;  1O98 A;  1ZED A;  3LXQ A;  1P49 A;  3BDG A;  1KH5 A;  5IJS A;  4NWJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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