1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
2GLQA 3IGYB 3TG0A 1EI6A 4GTZA 2ANHA 4B56A 1SHNA 3B5QA 4CXUA 5L0KA 4FDIA 1N2KA 3SZYA 1FSUA 1AJCA 1HDHA 4UORA 5GOVA 1HQAA 4UPLA 4LRCA 3IDDA 4LR8A 1ZEFA 3A52A 5C66A 2GSOA 4KM4A 1KH9A 1ELZA 1ALHA 3UN2A 3UN3A 5L0BA 2D1GA 4LR7A 2G9YA 3ED4A 3WAWA 4N7TA 2IUCA 3BDFA 1E1ZP 3UO0A 1HJKA 2XRGA 4CXSA 2W5TA 5TJ3A 1ZEDA 2W5WA 4LRAA 3M7VA 2W8SA 1AJDA 5LQQA 4ZGAA 4UPIA 1KH7A 4CXKA 3BDGA 3UNYA 4LRFA 5DLTA 3NKNA 2W5SA 1EW9A 1B8JA 1ANJA 3TX0A 1ELXA 1P49A 1ALIA 1EW2A 1ELYA 4LRDA 2W8DA 4MHXA 4MY4A 2X98A 3T02A 3CMRA 1ED9A 1SHQA 1K7HA 2GSUA 4LR2A 5HRTA 1E33P 3NKQA 1KHKA 3WBHA 1ED8A 3E2DA 4GTXA 3NVLA 5AJ9A 3LXQA 3UN5A 1ANIA 1O98A 4UOPA 3WAXA 3WAYA 5KXAA 4UPHA 4UPKA 3MK2A 5IJSA 1ALKA 4GTYA 1E2SP 4YR1A 3NKRA 3M8ZA 1URBA 1O99A 2W5QA 1ALJA 2IFYA 4NWXA 4TN0A 5LRMA 4CYSA 4CYRA 3SZZA 5LRNA 1EJJA 2VQRA 3T00A 1KH4A 4ZG7A 5GRRA 1AJAA 5EGHA 4MIVA 4KJGA 4KAYA 4QAXA 3DPCA 3M8WA 3NKPA 1AJBA 4UOOA 2IUCB 3Q3QA 2RH6A 4NWJA 3DYCA 3OT9A 1KHLA 4KAVA 5K4PA 3TWZA 3MK0A 4GTWA 5EGEA 3WAVA 3IGZB 3T01A 1URAA 4LR9A 1Y7AA 1KH5A 3NKOA 1ZEBA 1N2LA 4KJDA 3BDGB 1E3CP 1Y6VA 3M8YA 5DLWA 2GSNA 2GA3A 4LRBA 3MK1A 1KHNA 5DLVA 2W5XA 4ZG6A 5IJQA 3BDHA 5LIAA 5INHA 3KD8A 4FDJA 2QZUA 1EQJA 2XR9A 4ZG9A 2ZKTA 5L0EA 1KHJA 2W5RA 4LQYA 1AUKA 1EW8A 2W5VA 4LREA 3NKMA
chains in the Genus database with same CATH superfamily
2GLQA 3IGYB 3TG0A 1EI6A 4GTZA 2ANHA 4B56A 1SHNA 3B5QA 4CXUA 5L0KA 4FDIA 1N2KA 3SZYA 1FSUA 1AJCA 1HDHA 4UORA 5GOVA 1HQAA 4UPLA 4LRCA 3IDDA 4LR8A 1ZEFA 3A52A 5C66A 2GSOA 4KM4A 1KH9A 1ELZA 1ALHA 3UN2A 3UN3A 5L0BA 2D1GA 4LR7A 2G9YA 3ED4A 3WAWA 4N7TA 2IUCA 3BDFA 1E1ZP 3UO0A 1HJKA 2XRGA 4CXSA 2W5TA 5TJ3A 1ZEDA 2W5WA 4LRAA 3M7VA 2W8SA 1AJDA 5LQQA 4ZGAA 4UPIA 1KH7A 4CXKA 3BDGA 3UNYA 4LRFA 5DLTA 3NKNA 2W5SA 1EW9A 1B8JA 1ANJA 3TX0A 1ELXA 1P49A 1ALIA 1EW2A 1ELYA 4LRDA 2W8DA 4MHXA 4MY4A 2X98A 3T02A 3CMRA 1ED9A 1SHQA 1K7HA 2GSUA 4LR2A 5HRTA 1E33P 3NKQA 1KHKA 3WBHA 1ED8A 3E2DA 4GTXA 3NVLA 5AJ9A 3LXQA 3UN5A 1ANIA 1O98A 4UOPA 3WAXA 3WAYA 5KXAA 4UPHA 4UPKA 3MK2A 5IJSA 1ALKA 4GTYA 1E2SP 4YR1A 3NKRA 3M8ZA 1URBA 1O99A 2W5QA 1ALJA 2IFYA 4NWXA 4TN0A 5LRMA 4CYSA 4CYRA 3SZZA 5LRNA 1EJJA 2VQRA 3T00A 1KH4A 4ZG7A 5GRRA 1AJAA 5EGHA 4MIVA 4KJGA 4KAYA 4QAXA 3DPCA 3M8WA 3NKPA 1AJBA 4UOOA 2IUCB 3Q3QA 2RH6A 4NWJA 3DYCA 3OT9A 1KHLA 4KAVA 5K4PA 3TWZA 3MK0A 4GTWA 5EGEA 3WAVA 3IGZB 3T01A 1URAA 4LR9A 1Y7AA 1KH5A 3NKOA 1ZEBA 1N2LA 4KJDA 3BDGB 1E3CP 1Y6VA 3M8YA 5DLWA 2GSNA 2GA3A 4LRBA 3MK1A 1KHNA 5DLVA 2W5XA 4ZG6A 5IJQA 3BDHA 5LIAA 5INHA 3KD8A 4FDJA 2QZUA 1EQJA 2XR9A 4ZG9A 2ZKTA 5L0EA 1KHJA 2W5RA 4LQYA 1AUKA 1EW8A 2W5VA 4LREA 3NKMA
chains in the Genus database with same CATH topology
2GLQA 3IGYB 3TG0A 1EI6A 4GTZA 2ANHA 4B56A 1SHNA 3B5QA 4CXUA 5L0KA 4FDIA 1N2KA 3SZYA 1FSUA 1AJCA 1HDHA 4UORA 5GOVA 1HQAA 4UPLA 4LRCA 3IDDA 4LR8A 1ZEFA 3A52A 5C66A 2GSOA 4KM4A 1KH9A 1ELZA 1ALHA 3UN2A 3UN3A 5L0BA 2D1GA 4LR7A 2G9YA 3ED4A 3WAWA 4N7TA 2IUCA 3BDFA 1E1ZP 3UO0A 1HJKA 2XRGA 4CXSA 2W5TA 5TJ3A 1ZEDA 2W5WA 4LRAA 3M7VA 2W8SA 1AJDA 5LQQA 4ZGAA 4UPIA 1KH7A 4CXKA 3BDGA 3UNYA 4LRFA 5DLTA 3NKNA 2W5SA 1EW9A 1B8JA 1ANJA 3TX0A 1ELXA 1P49A 1ALIA 1EW2A 1ELYA 4LRDA 2W8DA 4MHXA 4MY4A 2X98A 3T02A 3CMRA 1ED9A 1SHQA 1K7HA 2GSUA 4LR2A 5HRTA 1E33P 3NKQA 1KHKA 3WBHA 1ED8A 3E2DA 4GTXA 3NVLA 5AJ9A 3LXQA 3UN5A 1ANIA 1O98A 4UOPA 3WAXA 3WAYA 5KXAA 4UPHA 4UPKA 3MK2A 5IJSA 1ALKA 4GTYA 1E2SP 4YR1A 3NKRA 3M8ZA 1URBA 1O99A 2W5QA 1ALJA 2IFYA 4NWXA 4TN0A 5LRMA 4CYSA 4CYRA 3SZZA 5LRNA 1EJJA 2VQRA 3T00A 1KH4A 4ZG7A 5GRRA 1AJAA 5EGHA 4MIVA 4KJGA 4KAYA 4QAXA 3DPCA 3M8WA 3NKPA 1AJBA 4UOOA 2IUCB 3Q3QA 2RH6A 4NWJA 3DYCA 3OT9A 1KHLA 4KAVA 5K4PA 3TWZA 3MK0A 4GTWA 5EGEA 3WAVA 3IGZB 3T01A 1URAA 4LR9A 1Y7AA 1KH5A 3NKOA 1ZEBA 1N2LA 4KJDA 3BDGB 1E3CP 1Y6VA 3M8YA 5DLWA 2GSNA 2GA3A 4LRBA 3MK1A 1KHNA 5DLVA 2W5XA 4ZG6A 5IJQA 3BDHA 5LIAA 5INHA 3KD8A 4FDJA 2QZUA 1EQJA 2XR9A 4ZG9A 2ZKTA 5L0EA 1KHJA 2W5RA 4LQYA 1AUKA 1EW8A 2W5VA 4LREA 3NKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GLQ A;  3IGY B;  3TG0 A;  1EI6 A;  4GTZ A;  2ANH A;  4B56 A;  1SHN A;  3B5Q A;  4CXU A;  5L0K A;  4FDI A;  1N2K A;  3SZY A;  1FSU A;  1AJC A;  1HDH A;  4UOR A;  5GOV A;  1HQA A;  4UPL A;  4LRC A;  3IDD A;  4LR8 A;  1ZEF A;  3A52 A;  5C66 A;  2GSO A;  4KM4 A;  1KH9 A;  1ELZ A;  1ALH A;  3UN2 A;  3UN3 A;  5L0B A;  2D1G A;  4LR7 A;  2G9Y A;  3ED4 A;  3WAW A;  4N7T A;  2IUC A;  3BDF A;  1E1Z P;  3UO0 A;  1HJK A;  2XRG A;  4CXS A;  2W5T A;  5TJ3 A;  1ZED A;  2W5W A;  4LRA A;  3M7V A;  2W8S A;  1AJD A;  5LQQ A;  4ZGA A;  4UPI A;  1KH7 A;  4CXK A;  3BDG A;  3UNY A;  4LRF A;  5DLT A;  3NKN A;  2W5S A;  1EW9 A;  1B8J A;  1ANJ A;  3TX0 A;  1ELX A;  1P49 A;  1ALI A;  1EW2 A;  1ELY A;  4LRD A;  2W8D A;  4MHX A;  4MY4 A;  2X98 A;  3T02 A;  3CMR A;  1ED9 A;  1SHQ A;  1K7H A;  2GSU A;  4LR2 A;  5HRT A;  1E33 P;  3NKQ A;  1KHK A;  3WBH A;  1ED8 A;  3E2D A;  4GTX A;  3NVL A;  5AJ9 A;  3LXQ A;  3UN5 A;  1ANI A;  1O98 A;  4UOP A;  3WAX A;  3WAY A;  5KXA A;  4UPH A;  4UPK A;  3MK2 A;  5IJS A;  1ALK A;  4GTY A;  1E2S P;  4YR1 A;  3NKR A;  3M8Z A;  1URB A;  1O99 A;  2W5Q A;  1ALJ A;  2IFY A;  4NWX A;  4TN0 A;  5LRM A;  4CYS A;  4CYR A;  3SZZ A;  5LRN A;  1EJJ A;  2VQR A;  3T00 A;  1KH4 A;  4ZG7 A;  5GRR A;  1AJA A;  5EGH A;  4MIV A;  4KJG A;  4KAY A;  4QAX A;  3DPC A;  3M8W A;  3NKP A;  1AJB A;  4UOO A;  2IUC B;  3Q3Q A;  2RH6 A;  4NWJ A;  3DYC A;  3OT9 A;  1KHL A;  4KAV A;  5K4P A;  3TWZ A;  3MK0 A;  4GTW A;  5EGE A;  3WAV A;  3IGZ B;  3T01 A;  1URA A;  4LR9 A;  1Y7A A;  1KH5 A;  3NKO A;  1ZEB A;  1N2L A;  4KJD A;  3BDG B;  1E3C P;  1Y6V A;  3M8Y A;  5DLW A;  2GSN A;  2GA3 A;  4LRB A;  3MK1 A;  1KHN A;  5DLV A;  2W5X A;  4ZG6 A;  5IJQ A;  3BDH A;  5LIA A;  5INH A;  3KD8 A;  4FDJ A;  2QZU A;  1EQJ A;  2XR9 A;  4ZG9 A;  2ZKT A;  5L0E A;  1KHJ A;  2W5R A;  4LQY A;  1AUK A;  1EW8 A;  2W5V A;  4LRE A;  3NKM A; 
#chains in the Genus database with same CATH topology
 2GLQ A;  3IGY B;  3TG0 A;  1EI6 A;  4GTZ A;  2ANH A;  4B56 A;  1SHN A;  3B5Q A;  4CXU A;  5L0K A;  4FDI A;  1N2K A;  3SZY A;  1FSU A;  1AJC A;  1HDH A;  4UOR A;  5GOV A;  1HQA A;  4UPL A;  4LRC A;  3IDD A;  4LR8 A;  1ZEF A;  3A52 A;  5C66 A;  2GSO A;  4KM4 A;  1KH9 A;  1ELZ A;  1ALH A;  3UN2 A;  3UN3 A;  5L0B A;  2D1G A;  4LR7 A;  2G9Y A;  3ED4 A;  3WAW A;  4N7T A;  2IUC A;  3BDF A;  1E1Z P;  3UO0 A;  1HJK A;  2XRG A;  4CXS A;  2W5T A;  5TJ3 A;  1ZED A;  2W5W A;  4LRA A;  3M7V A;  2W8S A;  1AJD A;  5LQQ A;  4ZGA A;  4UPI A;  1KH7 A;  4CXK A;  3BDG A;  3UNY A;  4LRF A;  5DLT A;  3NKN A;  2W5S A;  1EW9 A;  1B8J A;  1ANJ A;  3TX0 A;  1ELX A;  1P49 A;  1ALI A;  1EW2 A;  1ELY A;  4LRD A;  2W8D A;  4MHX A;  4MY4 A;  2X98 A;  3T02 A;  3CMR A;  1ED9 A;  1SHQ A;  1K7H A;  2GSU A;  4LR2 A;  5HRT A;  1E33 P;  3NKQ A;  1KHK A;  3WBH A;  1ED8 A;  3E2D A;  4GTX A;  3NVL A;  5AJ9 A;  3LXQ A;  3UN5 A;  1ANI A;  1O98 A;  4UOP A;  3WAX A;  3WAY A;  5KXA A;  4UPH A;  4UPK A;  3MK2 A;  5IJS A;  1ALK A;  4GTY A;  1E2S P;  4YR1 A;  3NKR A;  3M8Z A;  1URB A;  1O99 A;  2W5Q A;  1ALJ A;  2IFY A;  4NWX A;  4TN0 A;  5LRM A;  4CYS A;  4CYR A;  3SZZ A;  5LRN A;  1EJJ A;  2VQR A;  3T00 A;  1KH4 A;  4ZG7 A;  5GRR A;  1AJA A;  5EGH A;  4MIV A;  4KJG A;  4KAY A;  4QAX A;  3DPC A;  3M8W A;  3NKP A;  1AJB A;  4UOO A;  2IUC B;  3Q3Q A;  2RH6 A;  4NWJ A;  3DYC A;  3OT9 A;  1KHL A;  4KAV A;  5K4P A;  3TWZ A;  3MK0 A;  4GTW A;  5EGE A;  3WAV A;  3IGZ B;  3T01 A;  1URA A;  4LR9 A;  1Y7A A;  1KH5 A;  3NKO A;  1ZEB A;  1N2L A;  4KJD A;  3BDG B;  1E3C P;  1Y6V A;  3M8Y A;  5DLW A;  2GSN A;  2GA3 A;  4LRB A;  3MK1 A;  1KHN A;  5DLV A;  2W5X A;  4ZG6 A;  5IJQ A;  3BDH A;  5LIA A;  5INH A;  3KD8 A;  4FDJ A;  2QZU A;  1EQJ A;  2XR9 A;  4ZG9 A;  2ZKT A;  5L0E A;  1KHJ A;  2W5R A;  4LQY A;  1AUK A;  1EW8 A;  2W5V A;  4LRE A;  3NKM A; 
#chains in the Genus database with same CATH homology
 2GLQ A;  3IGY B;  3TG0 A;  1EI6 A;  4GTZ A;  2ANH A;  4B56 A;  1SHN A;  3B5Q A;  4CXU A;  5L0K A;  4FDI A;  1N2K A;  3SZY A;  1FSU A;  1AJC A;  1HDH A;  4UOR A;  5GOV A;  1HQA A;  4UPL A;  4LRC A;  3IDD A;  4LR8 A;  1ZEF A;  3A52 A;  5C66 A;  2GSO A;  4KM4 A;  1KH9 A;  1ELZ A;  1ALH A;  3UN2 A;  3UN3 A;  5L0B A;  2D1G A;  4LR7 A;  2G9Y A;  3ED4 A;  3WAW A;  4N7T A;  2IUC A;  3BDF A;  1E1Z P;  3UO0 A;  1HJK A;  2XRG A;  4CXS A;  2W5T A;  5TJ3 A;  1ZED A;  2W5W A;  4LRA A;  3M7V A;  2W8S A;  1AJD A;  5LQQ A;  4ZGA A;  4UPI A;  1KH7 A;  4CXK A;  3BDG A;  3UNY A;  4LRF A;  5DLT A;  3NKN A;  2W5S A;  1EW9 A;  1B8J A;  1ANJ A;  3TX0 A;  1ELX A;  1P49 A;  1ALI A;  1EW2 A;  1ELY A;  4LRD A;  2W8D A;  4MHX A;  4MY4 A;  2X98 A;  3T02 A;  3CMR A;  1ED9 A;  1SHQ A;  1K7H A;  2GSU A;  4LR2 A;  5HRT A;  1E33 P;  3NKQ A;  1KHK A;  3WBH A;  1ED8 A;  3E2D A;  4GTX A;  3NVL A;  5AJ9 A;  3LXQ A;  3UN5 A;  1ANI A;  1O98 A;  4UOP A;  3WAX A;  3WAY A;  5KXA A;  4UPH A;  4UPK A;  3MK2 A;  5IJS A;  1ALK A;  4GTY A;  1E2S P;  4YR1 A;  3NKR A;  3M8Z A;  1URB A;  1O99 A;  2W5Q A;  1ALJ A;  2IFY A;  4NWX A;  4TN0 A;  5LRM A;  4CYS A;  4CYR A;  3SZZ A;  5LRN A;  1EJJ A;  2VQR A;  3T00 A;  1KH4 A;  4ZG7 A;  5GRR A;  1AJA A;  5EGH A;  4MIV A;  4KJG A;  4KAY A;  4QAX A;  3DPC A;  3M8W A;  3NKP A;  1AJB A;  4UOO A;  2IUC B;  3Q3Q A;  2RH6 A;  4NWJ A;  3DYC A;  3OT9 A;  1KHL A;  4KAV A;  5K4P A;  3TWZ A;  3MK0 A;  4GTW A;  5EGE A;  3WAV A;  3IGZ B;  3T01 A;  1URA A;  4LR9 A;  1Y7A A;  1KH5 A;  3NKO A;  1ZEB A;  1N2L A;  4KJD A;  3BDG B;  1E3C P;  1Y6V A;  3M8Y A;  5DLW A;  2GSN A;  2GA3 A;  4LRB A;  3MK1 A;  1KHN A;  5DLV A;  2W5X A;  4ZG6 A;  5IJQ A;  3BDH A;  5LIA A;  5INH A;  3KD8 A;  4FDJ A;  2QZU A;  1EQJ A;  2XR9 A;  4ZG9 A;  2ZKT A;  5L0E A;  1KHJ A;  2W5R A;  4LQY A;  1AUK A;  1EW8 A;  2W5V A;  4LRE A;  3NKM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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