1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule keywords Alkaline phosphatase
molecule tags Hydrolase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
4MY4A 5EGEA 1ANJA 4B56A 3M8WA 4UOOA 3DPCA 5LQQA 1O99A 3BDGB 1FSUA 4KJDA 5L0BA 1AJAA 4UOPA 4QAXA 1HJKA 2W8DA 3NKPA 3WAVA 2QZUA 1EQJA 3M7VA 2G9YA 4ZG6A 1O98A 3SZZA 1KH4A 4FDJA 4UPKA 1E33P 3NKQA 4KM4A 1ALJA 4LR8A 1K7HA 2IUCB 3SZYA 3T01A 1ALKA 4GTYA 1SHQA 3ED4A 3M8ZA 4CYRA 3WBHA 1ZEFA 1AJCA 3BDHA 2GLQA 4GTWA 4KJGA 3UO0A 4CXUA 4UPLA 4ZGAA 5KXAA 4ZG7A 4CYSA 1ZEBA 3T02A 3NVLA 3TG0A 5INHA 5TJ3A 2W5TA 4YR1A 4UPIA 1EW2A 1E1ZP 2IFYA 1ELYA 1ED8A 4LR9A 2RH6A 5IJSA 3T00A 5L0KA 3UNYA 4CXKA 1URBA 1KH7A 2W5SA 3OT9A 1EI6A 3NKRA 3Q3QA 3UN2A 4UPHA 3UN5A 2VQRA 3NKNA 5DLVA 1ALHA 1KHLA 2D1GA 2GSNA 3B5QA 3LXQA 4LRCA 1KH9A 3BDGA 1ELZA 2W5QA 2W5RA 4FDIA 4LR2A 5HRTA 4CXSA 1ZEDA 5DLWA 1URAA 4LRBA 2X98A 3WAYA 2W5XA 3KD8A 1ELXA 2ZKTA 2IUCA 3MK1A 5K4PA 3IDDA 4NWJA 1E3CP 5IJQA 4NWXA 3UN3A 5C66A 1Y6VA 4LR7A 1Y7AA 5LRNA 1E2SP 3WAXA 1AUKA 2GSOA 4LRFA 4KAYA 1SHNA 1ALIA 3MK0A 4LREA 3MK2A 1KHKA 1N2LA 5DLTA 2GSUA 4LRDA 1P49A 3IGYB 1KHNA 3E2DA 4LRAA 3BDFA 5AJ9A 1HQAA 1EW8A 2W5VA 5L0EA 1EW9A 4LQYA 1KHJA 5LRMA 1HDHA 2W8SA 1ANIA 2GA3A 3NKMA 2XRGA 3TWZA 4KAVA 1EJJA 3M8YA 5GOVA 3IGZB 1KH5A 5EGHA 4MHXA 5LIAA 1AJDA 4ZG9A 4TN0A 3NKOA 4N7TA 1N2KA 1ED9A 5GRRA 4MIVA 3A52A 4GTXA 4UORA 1B8JA 2ANHA 3TX0A 3WAWA 2XR9A 3DYCA 2W5WA 4GTZA 1AJBA 3CMRA
chains in the Genus database with same CATH superfamily
4MY4A 5EGEA 1ANJA 4B56A 3M8WA 4UOOA 3DPCA 5LQQA 1O99A 3BDGB 1FSUA 4KJDA 5L0BA 1AJAA 4UOPA 4QAXA 1HJKA 2W8DA 3NKPA 3WAVA 2QZUA 1EQJA 3M7VA 2G9YA 4ZG6A 1O98A 3SZZA 1KH4A 4FDJA 4UPKA 1E33P 3NKQA 4KM4A 1ALJA 4LR8A 1K7HA 2IUCB 3SZYA 3T01A 1ALKA 4GTYA 1SHQA 3ED4A 3M8ZA 4CYRA 3WBHA 1ZEFA 1AJCA 3BDHA 2GLQA 4GTWA 4KJGA 3UO0A 4CXUA 4UPLA 4ZGAA 5KXAA 4ZG7A 4CYSA 1ZEBA 3T02A 3NVLA 3TG0A 5INHA 5TJ3A 2W5TA 4YR1A 4UPIA 1EW2A 1E1ZP 2IFYA 1ELYA 1ED8A 4LR9A 2RH6A 5IJSA 3T00A 5L0KA 3UNYA 4CXKA 1URBA 1KH7A 2W5SA 3OT9A 1EI6A 3NKRA 3Q3QA 3UN2A 4UPHA 3UN5A 2VQRA 3NKNA 5DLVA 1ALHA 1KHLA 2D1GA 2GSNA 3B5QA 3LXQA 4LRCA 1KH9A 3BDGA 1ELZA 2W5QA 2W5RA 4FDIA 4LR2A 5HRTA 4CXSA 1ZEDA 5DLWA 1URAA 4LRBA 2X98A 3WAYA 2W5XA 3KD8A 1ELXA 2ZKTA 2IUCA 3MK1A 5K4PA 3IDDA 4NWJA 1E3CP 5IJQA 4NWXA 3UN3A 5C66A 1Y6VA 4LR7A 1Y7AA 5LRNA 1E2SP 3WAXA 1AUKA 2GSOA 4LRFA 4KAYA 1SHNA 1ALIA 3MK0A 4LREA 3MK2A 1KHKA 1N2LA 5DLTA 2GSUA 4LRDA 1P49A 3IGYB 1KHNA 3E2DA 4LRAA 3BDFA 5AJ9A 1HQAA 1EW8A 2W5VA 5L0EA 1EW9A 4LQYA 1KHJA 5LRMA 1HDHA 2W8SA 1ANIA 2GA3A 3NKMA 2XRGA 3TWZA 4KAVA 1EJJA 3M8YA 5GOVA 3IGZB 1KH5A 5EGHA 4MHXA 5LIAA 1AJDA 4ZG9A 4TN0A 3NKOA 4N7TA 1N2KA 1ED9A 5GRRA 4MIVA 3A52A 4GTXA 4UORA 1B8JA 2ANHA 3TX0A 3WAWA 2XR9A 3DYCA 2W5WA 4GTZA 1AJBA 3CMRA
chains in the Genus database with same CATH topology
4MY4A 5EGEA 1ANJA 4B56A 3M8WA 4UOOA 3DPCA 5LQQA 1O99A 3BDGB 1FSUA 4KJDA 5L0BA 1AJAA 4UOPA 4QAXA 1HJKA 2W8DA 3NKPA 3WAVA 2QZUA 1EQJA 3M7VA 2G9YA 4ZG6A 1O98A 3SZZA 1KH4A 4FDJA 4UPKA 1E33P 3NKQA 4KM4A 1ALJA 4LR8A 1K7HA 2IUCB 3SZYA 3T01A 1ALKA 4GTYA 1SHQA 3ED4A 3M8ZA 4CYRA 3WBHA 1ZEFA 1AJCA 3BDHA 2GLQA 4GTWA 4KJGA 3UO0A 4CXUA 4UPLA 4ZGAA 5KXAA 4ZG7A 4CYSA 1ZEBA 3T02A 3NVLA 3TG0A 5INHA 5TJ3A 2W5TA 4YR1A 4UPIA 1EW2A 1E1ZP 2IFYA 1ELYA 1ED8A 4LR9A 2RH6A 5IJSA 3T00A 5L0KA 3UNYA 4CXKA 1URBA 1KH7A 2W5SA 3OT9A 1EI6A 3NKRA 3Q3QA 3UN2A 4UPHA 3UN5A 2VQRA 3NKNA 5DLVA 1ALHA 1KHLA 2D1GA 2GSNA 3B5QA 3LXQA 4LRCA 1KH9A 3BDGA 1ELZA 2W5QA 2W5RA 4FDIA 4LR2A 5HRTA 4CXSA 1ZEDA 5DLWA 1URAA 4LRBA 2X98A 3WAYA 2W5XA 3KD8A 1ELXA 2ZKTA 2IUCA 3MK1A 5K4PA 3IDDA 4NWJA 1E3CP 5IJQA 4NWXA 3UN3A 5C66A 1Y6VA 4LR7A 1Y7AA 5LRNA 1E2SP 3WAXA 1AUKA 2GSOA 4LRFA 4KAYA 1SHNA 1ALIA 3MK0A 4LREA 3MK2A 1KHKA 1N2LA 5DLTA 2GSUA 4LRDA 1P49A 3IGYB 1KHNA 3E2DA 4LRAA 3BDFA 5AJ9A 1HQAA 1EW8A 2W5VA 5L0EA 1EW9A 4LQYA 1KHJA 5LRMA 1HDHA 2W8SA 1ANIA 2GA3A 3NKMA 2XRGA 3TWZA 4KAVA 1EJJA 3M8YA 5GOVA 3IGZB 1KH5A 5EGHA 4MHXA 5LIAA 1AJDA 4ZG9A 4TN0A 3NKOA 4N7TA 1N2KA 1ED9A 5GRRA 4MIVA 3A52A 4GTXA 4UORA 1B8JA 2ANHA 3TX0A 3WAWA 2XR9A 3DYCA 2W5WA 4GTZA 1AJBA 3CMRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MY4 A;  5EGE A;  1ANJ A;  4B56 A;  3M8W A;  4UOO A;  3DPC A;  5LQQ A;  1O99 A;  3BDG B;  1FSU A;  4KJD A;  5L0B A;  1AJA A;  4UOP A;  4QAX A;  1HJK A;  2W8D A;  3NKP A;  3WAV A;  2QZU A;  1EQJ A;  3M7V A;  2G9Y A;  4ZG6 A;  1O98 A;  3SZZ A;  1KH4 A;  4FDJ A;  4UPK A;  1E33 P;  3NKQ A;  4KM4 A;  1ALJ A;  4LR8 A;  1K7H A;  2IUC B;  3SZY A;  3T01 A;  1ALK A;  4GTY A;  1SHQ A;  3ED4 A;  3M8Z A;  4CYR A;  3WBH A;  1ZEF A;  1AJC A;  3BDH A;  2GLQ A;  4GTW A;  4KJG A;  3UO0 A;  4CXU A;  4UPL A;  4ZGA A;  5KXA A;  4ZG7 A;  4CYS A;  1ZEB A;  3T02 A;  3NVL A;  3TG0 A;  5INH A;  5TJ3 A;  2W5T A;  4YR1 A;  4UPI A;  1EW2 A;  1E1Z P;  2IFY A;  1ELY A;  1ED8 A;  4LR9 A;  2RH6 A;  5IJS A;  3T00 A;  5L0K A;  3UNY A;  4CXK A;  1URB A;  1KH7 A;  2W5S A;  3OT9 A;  1EI6 A;  3NKR A;  3Q3Q A;  3UN2 A;  4UPH A;  3UN5 A;  2VQR A;  3NKN A;  5DLV A;  1ALH A;  1KHL A;  2D1G A;  2GSN A;  3B5Q A;  3LXQ A;  4LRC A;  1KH9 A;  3BDG A;  1ELZ A;  2W5Q A;  2W5R A;  4FDI A;  4LR2 A;  5HRT A;  4CXS A;  1ZED A;  5DLW A;  1URA A;  4LRB A;  2X98 A;  3WAY A;  2W5X A;  3KD8 A;  1ELX A;  2ZKT A;  2IUC A;  3MK1 A;  5K4P A;  3IDD A;  4NWJ A;  1E3C P;  5IJQ A;  4NWX A;  3UN3 A;  5C66 A;  1Y6V A;  4LR7 A;  1Y7A A;  5LRN A;  1E2S P;  3WAX A;  1AUK A;  2GSO A;  4LRF A;  4KAY A;  1SHN A;  1ALI A;  3MK0 A;  4LRE A;  3MK2 A;  1KHK A;  1N2L A;  5DLT A;  2GSU A;  4LRD A;  1P49 A;  3IGY B;  1KHN A;  3E2D A;  4LRA A;  3BDF A;  5AJ9 A;  1HQA A;  1EW8 A;  2W5V A;  5L0E A;  1EW9 A;  4LQY A;  1KHJ A;  5LRM A;  1HDH A;  2W8S A;  1ANI A;  2GA3 A;  3NKM A;  2XRG A;  3TWZ A;  4KAV A;  1EJJ A;  3M8Y A;  5GOV A;  3IGZ B;  1KH5 A;  5EGH A;  4MHX A;  5LIA A;  1AJD A;  4ZG9 A;  4TN0 A;  3NKO A;  4N7T A;  1N2K A;  1ED9 A;  5GRR A;  4MIV A;  3A52 A;  4GTX A;  4UOR A;  1B8J A;  2ANH A;  3TX0 A;  3WAW A;  2XR9 A;  3DYC A;  2W5W A;  4GTZ A;  1AJB A;  3CMR A; 
#chains in the Genus database with same CATH topology
 4MY4 A;  5EGE A;  1ANJ A;  4B56 A;  3M8W A;  4UOO A;  3DPC A;  5LQQ A;  1O99 A;  3BDG B;  1FSU A;  4KJD A;  5L0B A;  1AJA A;  4UOP A;  4QAX A;  1HJK A;  2W8D A;  3NKP A;  3WAV A;  2QZU A;  1EQJ A;  3M7V A;  2G9Y A;  4ZG6 A;  1O98 A;  3SZZ A;  1KH4 A;  4FDJ A;  4UPK A;  1E33 P;  3NKQ A;  4KM4 A;  1ALJ A;  4LR8 A;  1K7H A;  2IUC B;  3SZY A;  3T01 A;  1ALK A;  4GTY A;  1SHQ A;  3ED4 A;  3M8Z A;  4CYR A;  3WBH A;  1ZEF A;  1AJC A;  3BDH A;  2GLQ A;  4GTW A;  4KJG A;  3UO0 A;  4CXU A;  4UPL A;  4ZGA A;  5KXA A;  4ZG7 A;  4CYS A;  1ZEB A;  3T02 A;  3NVL A;  3TG0 A;  5INH A;  5TJ3 A;  2W5T A;  4YR1 A;  4UPI A;  1EW2 A;  1E1Z P;  2IFY A;  1ELY A;  1ED8 A;  4LR9 A;  2RH6 A;  5IJS A;  3T00 A;  5L0K A;  3UNY A;  4CXK A;  1URB A;  1KH7 A;  2W5S A;  3OT9 A;  1EI6 A;  3NKR A;  3Q3Q A;  3UN2 A;  4UPH A;  3UN5 A;  2VQR A;  3NKN A;  5DLV A;  1ALH A;  1KHL A;  2D1G A;  2GSN A;  3B5Q A;  3LXQ A;  4LRC A;  1KH9 A;  3BDG A;  1ELZ A;  2W5Q A;  2W5R A;  4FDI A;  4LR2 A;  5HRT A;  4CXS A;  1ZED A;  5DLW A;  1URA A;  4LRB A;  2X98 A;  3WAY A;  2W5X A;  3KD8 A;  1ELX A;  2ZKT A;  2IUC A;  3MK1 A;  5K4P A;  3IDD A;  4NWJ A;  1E3C P;  5IJQ A;  4NWX A;  3UN3 A;  5C66 A;  1Y6V A;  4LR7 A;  1Y7A A;  5LRN A;  1E2S P;  3WAX A;  1AUK A;  2GSO A;  4LRF A;  4KAY A;  1SHN A;  1ALI A;  3MK0 A;  4LRE A;  3MK2 A;  1KHK A;  1N2L A;  5DLT A;  2GSU A;  4LRD A;  1P49 A;  3IGY B;  1KHN A;  3E2D A;  4LRA A;  3BDF A;  5AJ9 A;  1HQA A;  1EW8 A;  2W5V A;  5L0E A;  1EW9 A;  4LQY A;  1KHJ A;  5LRM A;  1HDH A;  2W8S A;  1ANI A;  2GA3 A;  3NKM A;  2XRG A;  3TWZ A;  4KAV A;  1EJJ A;  3M8Y A;  5GOV A;  3IGZ B;  1KH5 A;  5EGH A;  4MHX A;  5LIA A;  1AJD A;  4ZG9 A;  4TN0 A;  3NKO A;  4N7T A;  1N2K A;  1ED9 A;  5GRR A;  4MIV A;  3A52 A;  4GTX A;  4UOR A;  1B8J A;  2ANH A;  3TX0 A;  3WAW A;  2XR9 A;  3DYC A;  2W5W A;  4GTZ A;  1AJB A;  3CMR A; 
#chains in the Genus database with same CATH homology
 4MY4 A;  5EGE A;  1ANJ A;  4B56 A;  3M8W A;  4UOO A;  3DPC A;  5LQQ A;  1O99 A;  3BDG B;  1FSU A;  4KJD A;  5L0B A;  1AJA A;  4UOP A;  4QAX A;  1HJK A;  2W8D A;  3NKP A;  3WAV A;  2QZU A;  1EQJ A;  3M7V A;  2G9Y A;  4ZG6 A;  1O98 A;  3SZZ A;  1KH4 A;  4FDJ A;  4UPK A;  1E33 P;  3NKQ A;  4KM4 A;  1ALJ A;  4LR8 A;  1K7H A;  2IUC B;  3SZY A;  3T01 A;  1ALK A;  4GTY A;  1SHQ A;  3ED4 A;  3M8Z A;  4CYR A;  3WBH A;  1ZEF A;  1AJC A;  3BDH A;  2GLQ A;  4GTW A;  4KJG A;  3UO0 A;  4CXU A;  4UPL A;  4ZGA A;  5KXA A;  4ZG7 A;  4CYS A;  1ZEB A;  3T02 A;  3NVL A;  3TG0 A;  5INH A;  5TJ3 A;  2W5T A;  4YR1 A;  4UPI A;  1EW2 A;  1E1Z P;  2IFY A;  1ELY A;  1ED8 A;  4LR9 A;  2RH6 A;  5IJS A;  3T00 A;  5L0K A;  3UNY A;  4CXK A;  1URB A;  1KH7 A;  2W5S A;  3OT9 A;  1EI6 A;  3NKR A;  3Q3Q A;  3UN2 A;  4UPH A;  3UN5 A;  2VQR A;  3NKN A;  5DLV A;  1ALH A;  1KHL A;  2D1G A;  2GSN A;  3B5Q A;  3LXQ A;  4LRC A;  1KH9 A;  3BDG A;  1ELZ A;  2W5Q A;  2W5R A;  4FDI A;  4LR2 A;  5HRT A;  4CXS A;  1ZED A;  5DLW A;  1URA A;  4LRB A;  2X98 A;  3WAY A;  2W5X A;  3KD8 A;  1ELX A;  2ZKT A;  2IUC A;  3MK1 A;  5K4P A;  3IDD A;  4NWJ A;  1E3C P;  5IJQ A;  4NWX A;  3UN3 A;  5C66 A;  1Y6V A;  4LR7 A;  1Y7A A;  5LRN A;  1E2S P;  3WAX A;  1AUK A;  2GSO A;  4LRF A;  4KAY A;  1SHN A;  1ALI A;  3MK0 A;  4LRE A;  3MK2 A;  1KHK A;  1N2L A;  5DLT A;  2GSU A;  4LRD A;  1P49 A;  3IGY B;  1KHN A;  3E2D A;  4LRA A;  3BDF A;  5AJ9 A;  1HQA A;  1EW8 A;  2W5V A;  5L0E A;  1EW9 A;  4LQY A;  1KHJ A;  5LRM A;  1HDH A;  2W8S A;  1ANI A;  2GA3 A;  3NKM A;  2XRG A;  3TWZ A;  4KAV A;  1EJJ A;  3M8Y A;  5GOV A;  3IGZ B;  1KH5 A;  5EGH A;  4MHX A;  5LIA A;  1AJD A;  4ZG9 A;  4TN0 A;  3NKO A;  4N7T A;  1N2K A;  1ED9 A;  5GRR A;  4MIV A;  3A52 A;  4GTX A;  4UOR A;  1B8J A;  2ANH A;  3TX0 A;  3WAW A;  2XR9 A;  3DYC A;  2W5W A;  4GTZ A;  1AJB A;  3CMR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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