1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule keywords Alkaline phosphatase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
4CXSA 3CMRA 3UN5A 4UPIA 4TN0A 4LRBA 1ALHA 4UPHA 5K4PA 1SHNA 5HRTA 1EQJA 3KD8A 3M7VA 4ZG9A 4ZGAA 1EW9A 2W5VA 3WAWA 4CYSA 4FDIA 1N2LA 1KHKA 1URBA 1Y6VA 1ED9A 3MK0A 4GTWA 5C66A 3MK2A 4CXKA 1E3CP 3TWZA 5LRNA 3WAXA 4GTYA 3B5QA 1KH5A 3SZYA 2XR9A 1SHQA 3TG0A 2W5XA 4B56A 1AJCA 2W5WA 3IGZB 1ANJA 3NKNA 3IGYB 4NWJA 5AJ9A 1E1ZP 2X98A 4UOOA 2GLQA 5DLWA 3WAVA 1E2SP 5EGEA 3A52A 5IJQA 1AJDA 1N2KA 4KJGA 3TX0A 4KM4A 1URAA 5EGHA 4CYRA 5LQQA 4YR1A 5IJSA 3NVLA 4GTZA 4UPLA 1O99A 3SZZA 3UN3A 4LR7A 1P49A 1Y7AA 1KHLA 1AJAA 4GTXA 4LREA 5GRRA 2W8SA 2D1GA 3BDGA 1HQAA 3UN2A 4KAVA 2RH6A 2W5SA 2ZKTA 1EW2A 2W5TA 1KH4A 2GSOA 1EI6A 4UOPA 3UNYA 3WAYA 1B8JA 1ALKA 1ZEDA 2GSUA 4NWXA 1ELYA 1ZEBA 1E33P 2IUCB 2W8DA 1KH7A 5TJ3A 2IFYA 3NKQA 3WBHA 2XRGA 1K7HA 3BDHA 3NKMA 5L0EA 5LRMA 3Q3QA 4LRCA 1ELZA 1HJKA 2GSNA 1EW8A 3BDFA 3MK1A 4LR2A 4LRFA 4N7TA 1HDHA 3M8ZA 1ALJA 5LIAA 3ED4A 1AJBA 3NKPA 5DLVA 1ZEFA 3LXQA 5L0KA 4LR9A 5KXAA 4FDJA 1FSUA 1ELXA 1KHJA 3IDDA 1EJJA 2G9YA 2GA3A 4LR8A 3DYCA 4LQYA 3NKOA 3E2DA 5DLTA 4MIVA 4ZG6A 2ANHA 4LRAA 4MHXA 4MY4A 1ED8A 4UORA 3UO0A 2VQRA 4QAXA 5INHA 1AUKA 4ZG7A 2QZUA 3M8YA 3BDGB 3NKRA 4KAYA 2IUCA 2W5RA 1ALIA 1KH9A 3DPCA 3T01A 1ANIA 3T00A 4CXUA 5L0BA 4KJDA 4UPKA 3T02A 3OT9A 4LRDA 2W5QA 1O98A 1KHNA 5GOVA 3M8WA
chains in the Genus database with same CATH superfamily
4CXSA 3CMRA 3UN5A 4UPIA 4TN0A 4LRBA 1ALHA 4UPHA 5K4PA 1SHNA 5HRTA 1EQJA 3KD8A 3M7VA 4ZG9A 4ZGAA 1EW9A 2W5VA 3WAWA 4CYSA 4FDIA 1N2LA 1KHKA 1URBA 1Y6VA 1ED9A 3MK0A 4GTWA 5C66A 3MK2A 4CXKA 1E3CP 3TWZA 5LRNA 3WAXA 4GTYA 3B5QA 1KH5A 3SZYA 2XR9A 1SHQA 3TG0A 2W5XA 4B56A 1AJCA 2W5WA 3IGZB 1ANJA 3NKNA 3IGYB 4NWJA 5AJ9A 1E1ZP 2X98A 4UOOA 2GLQA 5DLWA 3WAVA 1E2SP 5EGEA 3A52A 5IJQA 1AJDA 1N2KA 4KJGA 3TX0A 4KM4A 1URAA 5EGHA 4CYRA 5LQQA 4YR1A 5IJSA 3NVLA 4GTZA 4UPLA 1O99A 3SZZA 3UN3A 4LR7A 1P49A 1Y7AA 1KHLA 1AJAA 4GTXA 4LREA 5GRRA 2W8SA 2D1GA 3BDGA 1HQAA 3UN2A 4KAVA 2RH6A 2W5SA 2ZKTA 1EW2A 2W5TA 1KH4A 2GSOA 1EI6A 4UOPA 3UNYA 3WAYA 1B8JA 1ALKA 1ZEDA 2GSUA 4NWXA 1ELYA 1ZEBA 1E33P 2IUCB 2W8DA 1KH7A 5TJ3A 2IFYA 3NKQA 3WBHA 2XRGA 1K7HA 3BDHA 3NKMA 5L0EA 5LRMA 3Q3QA 4LRCA 1ELZA 1HJKA 2GSNA 1EW8A 3BDFA 3MK1A 4LR2A 4LRFA 4N7TA 1HDHA 3M8ZA 1ALJA 5LIAA 3ED4A 1AJBA 3NKPA 5DLVA 1ZEFA 3LXQA 5L0KA 4LR9A 5KXAA 4FDJA 1FSUA 1ELXA 1KHJA 3IDDA 1EJJA 2G9YA 2GA3A 4LR8A 3DYCA 4LQYA 3NKOA 3E2DA 5DLTA 4MIVA 4ZG6A 2ANHA 4LRAA 4MHXA 4MY4A 1ED8A 4UORA 3UO0A 2VQRA 4QAXA 5INHA 1AUKA 4ZG7A 2QZUA 3M8YA 3BDGB 3NKRA 4KAYA 2IUCA 2W5RA 1ALIA 1KH9A 3DPCA 3T01A 1ANIA 3T00A 4CXUA 5L0BA 4KJDA 4UPKA 3T02A 3OT9A 4LRDA 2W5QA 1O98A 1KHNA 5GOVA 3M8WA
chains in the Genus database with same CATH topology
4CXSA 3CMRA 3UN5A 4UPIA 4TN0A 4LRBA 1ALHA 4UPHA 5K4PA 1SHNA 5HRTA 1EQJA 3KD8A 3M7VA 4ZG9A 4ZGAA 1EW9A 2W5VA 3WAWA 4CYSA 4FDIA 1N2LA 1KHKA 1URBA 1Y6VA 1ED9A 3MK0A 4GTWA 5C66A 3MK2A 4CXKA 1E3CP 3TWZA 5LRNA 3WAXA 4GTYA 3B5QA 1KH5A 3SZYA 2XR9A 1SHQA 3TG0A 2W5XA 4B56A 1AJCA 2W5WA 3IGZB 1ANJA 3NKNA 3IGYB 4NWJA 5AJ9A 1E1ZP 2X98A 4UOOA 2GLQA 5DLWA 3WAVA 1E2SP 5EGEA 3A52A 5IJQA 1AJDA 1N2KA 4KJGA 3TX0A 4KM4A 1URAA 5EGHA 4CYRA 5LQQA 4YR1A 5IJSA 3NVLA 4GTZA 4UPLA 1O99A 3SZZA 3UN3A 4LR7A 1P49A 1Y7AA 1KHLA 1AJAA 4GTXA 4LREA 5GRRA 2W8SA 2D1GA 3BDGA 1HQAA 3UN2A 4KAVA 2RH6A 2W5SA 2ZKTA 1EW2A 2W5TA 1KH4A 2GSOA 1EI6A 4UOPA 3UNYA 3WAYA 1B8JA 1ALKA 1ZEDA 2GSUA 4NWXA 1ELYA 1ZEBA 1E33P 2IUCB 2W8DA 1KH7A 5TJ3A 2IFYA 3NKQA 3WBHA 2XRGA 1K7HA 3BDHA 3NKMA 5L0EA 5LRMA 3Q3QA 4LRCA 1ELZA 1HJKA 2GSNA 1EW8A 3BDFA 3MK1A 4LR2A 4LRFA 4N7TA 1HDHA 3M8ZA 1ALJA 5LIAA 3ED4A 1AJBA 3NKPA 5DLVA 1ZEFA 3LXQA 5L0KA 4LR9A 5KXAA 4FDJA 1FSUA 1ELXA 1KHJA 3IDDA 1EJJA 2G9YA 2GA3A 4LR8A 3DYCA 4LQYA 3NKOA 3E2DA 5DLTA 4MIVA 4ZG6A 2ANHA 4LRAA 4MHXA 4MY4A 1ED8A 4UORA 3UO0A 2VQRA 4QAXA 5INHA 1AUKA 4ZG7A 2QZUA 3M8YA 3BDGB 3NKRA 4KAYA 2IUCA 2W5RA 1ALIA 1KH9A 3DPCA 3T01A 1ANIA 3T00A 4CXUA 5L0BA 4KJDA 4UPKA 3T02A 3OT9A 4LRDA 2W5QA 1O98A 1KHNA 5GOVA 3M8WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CXS A;  3CMR A;  3UN5 A;  4UPI A;  4TN0 A;  4LRB A;  1ALH A;  4UPH A;  5K4P A;  1SHN A;  5HRT A;  1EQJ A;  3KD8 A;  3M7V A;  4ZG9 A;  4ZGA A;  1EW9 A;  2W5V A;  3WAW A;  4CYS A;  4FDI A;  1N2L A;  1KHK A;  1URB A;  1Y6V A;  1ED9 A;  3MK0 A;  4GTW A;  5C66 A;  3MK2 A;  4CXK A;  1E3C P;  3TWZ A;  5LRN A;  3WAX A;  4GTY A;  3B5Q A;  1KH5 A;  3SZY A;  2XR9 A;  1SHQ A;  3TG0 A;  2W5X A;  4B56 A;  1AJC A;  2W5W A;  3IGZ B;  1ANJ A;  3NKN A;  3IGY B;  4NWJ A;  5AJ9 A;  1E1Z P;  2X98 A;  4UOO A;  2GLQ A;  5DLW A;  3WAV A;  1E2S P;  5EGE A;  3A52 A;  5IJQ A;  1AJD A;  1N2K A;  4KJG A;  3TX0 A;  4KM4 A;  1URA A;  5EGH A;  4CYR A;  5LQQ A;  4YR1 A;  5IJS A;  3NVL A;  4GTZ A;  4UPL A;  1O99 A;  3SZZ A;  3UN3 A;  4LR7 A;  1P49 A;  1Y7A A;  1KHL A;  1AJA A;  4GTX A;  4LRE A;  5GRR A;  2W8S A;  2D1G A;  3BDG A;  1HQA A;  3UN2 A;  4KAV A;  2RH6 A;  2W5S A;  2ZKT A;  1EW2 A;  2W5T A;  1KH4 A;  2GSO A;  1EI6 A;  4UOP A;  3UNY A;  3WAY A;  1B8J A;  1ALK A;  1ZED A;  2GSU A;  4NWX A;  1ELY A;  1ZEB A;  1E33 P;  2IUC B;  2W8D A;  1KH7 A;  5TJ3 A;  2IFY A;  3NKQ A;  3WBH A;  2XRG A;  1K7H A;  3BDH A;  3NKM A;  5L0E A;  5LRM A;  3Q3Q A;  4LRC A;  1ELZ A;  1HJK A;  2GSN A;  1EW8 A;  3BDF A;  3MK1 A;  4LR2 A;  4LRF A;  4N7T A;  1HDH A;  3M8Z A;  1ALJ A;  5LIA A;  3ED4 A;  1AJB A;  3NKP A;  5DLV A;  1ZEF A;  3LXQ A;  5L0K A;  4LR9 A;  5KXA A;  4FDJ A;  1FSU A;  1ELX A;  1KHJ A;  3IDD A;  1EJJ A;  2G9Y A;  2GA3 A;  4LR8 A;  3DYC A;  4LQY A;  3NKO A;  3E2D A;  5DLT A;  4MIV A;  4ZG6 A;  2ANH A;  4LRA A;  4MHX A;  4MY4 A;  1ED8 A;  4UOR A;  3UO0 A;  2VQR A;  4QAX A;  5INH A;  1AUK A;  4ZG7 A;  2QZU A;  3M8Y A;  3BDG B;  3NKR A;  4KAY A;  2IUC A;  2W5R A;  1ALI A;  1KH9 A;  3DPC A;  3T01 A;  1ANI A;  3T00 A;  4CXU A;  5L0B A;  4KJD A;  4UPK A;  3T02 A;  3OT9 A;  4LRD A;  2W5Q A;  1O98 A;  1KHN A;  5GOV A;  3M8W A; 
#chains in the Genus database with same CATH topology
 4CXS A;  3CMR A;  3UN5 A;  4UPI A;  4TN0 A;  4LRB A;  1ALH A;  4UPH A;  5K4P A;  1SHN A;  5HRT A;  1EQJ A;  3KD8 A;  3M7V A;  4ZG9 A;  4ZGA A;  1EW9 A;  2W5V A;  3WAW A;  4CYS A;  4FDI A;  1N2L A;  1KHK A;  1URB A;  1Y6V A;  1ED9 A;  3MK0 A;  4GTW A;  5C66 A;  3MK2 A;  4CXK A;  1E3C P;  3TWZ A;  5LRN A;  3WAX A;  4GTY A;  3B5Q A;  1KH5 A;  3SZY A;  2XR9 A;  1SHQ A;  3TG0 A;  2W5X A;  4B56 A;  1AJC A;  2W5W A;  3IGZ B;  1ANJ A;  3NKN A;  3IGY B;  4NWJ A;  5AJ9 A;  1E1Z P;  2X98 A;  4UOO A;  2GLQ A;  5DLW A;  3WAV A;  1E2S P;  5EGE A;  3A52 A;  5IJQ A;  1AJD A;  1N2K A;  4KJG A;  3TX0 A;  4KM4 A;  1URA A;  5EGH A;  4CYR A;  5LQQ A;  4YR1 A;  5IJS A;  3NVL A;  4GTZ A;  4UPL A;  1O99 A;  3SZZ A;  3UN3 A;  4LR7 A;  1P49 A;  1Y7A A;  1KHL A;  1AJA A;  4GTX A;  4LRE A;  5GRR A;  2W8S A;  2D1G A;  3BDG A;  1HQA A;  3UN2 A;  4KAV A;  2RH6 A;  2W5S A;  2ZKT A;  1EW2 A;  2W5T A;  1KH4 A;  2GSO A;  1EI6 A;  4UOP A;  3UNY A;  3WAY A;  1B8J A;  1ALK A;  1ZED A;  2GSU A;  4NWX A;  1ELY A;  1ZEB A;  1E33 P;  2IUC B;  2W8D A;  1KH7 A;  5TJ3 A;  2IFY A;  3NKQ A;  3WBH A;  2XRG A;  1K7H A;  3BDH A;  3NKM A;  5L0E A;  5LRM A;  3Q3Q A;  4LRC A;  1ELZ A;  1HJK A;  2GSN A;  1EW8 A;  3BDF A;  3MK1 A;  4LR2 A;  4LRF A;  4N7T A;  1HDH A;  3M8Z A;  1ALJ A;  5LIA A;  3ED4 A;  1AJB A;  3NKP A;  5DLV A;  1ZEF A;  3LXQ A;  5L0K A;  4LR9 A;  5KXA A;  4FDJ A;  1FSU A;  1ELX A;  1KHJ A;  3IDD A;  1EJJ A;  2G9Y A;  2GA3 A;  4LR8 A;  3DYC A;  4LQY A;  3NKO A;  3E2D A;  5DLT A;  4MIV A;  4ZG6 A;  2ANH A;  4LRA A;  4MHX A;  4MY4 A;  1ED8 A;  4UOR A;  3UO0 A;  2VQR A;  4QAX A;  5INH A;  1AUK A;  4ZG7 A;  2QZU A;  3M8Y A;  3BDG B;  3NKR A;  4KAY A;  2IUC A;  2W5R A;  1ALI A;  1KH9 A;  3DPC A;  3T01 A;  1ANI A;  3T00 A;  4CXU A;  5L0B A;  4KJD A;  4UPK A;  3T02 A;  3OT9 A;  4LRD A;  2W5Q A;  1O98 A;  1KHN A;  5GOV A;  3M8W A; 
#chains in the Genus database with same CATH homology
 4CXS A;  3CMR A;  3UN5 A;  4UPI A;  4TN0 A;  4LRB A;  1ALH A;  4UPH A;  5K4P A;  1SHN A;  5HRT A;  1EQJ A;  3KD8 A;  3M7V A;  4ZG9 A;  4ZGA A;  1EW9 A;  2W5V A;  3WAW A;  4CYS A;  4FDI A;  1N2L A;  1KHK A;  1URB A;  1Y6V A;  1ED9 A;  3MK0 A;  4GTW A;  5C66 A;  3MK2 A;  4CXK A;  1E3C P;  3TWZ A;  5LRN A;  3WAX A;  4GTY A;  3B5Q A;  1KH5 A;  3SZY A;  2XR9 A;  1SHQ A;  3TG0 A;  2W5X A;  4B56 A;  1AJC A;  2W5W A;  3IGZ B;  1ANJ A;  3NKN A;  3IGY B;  4NWJ A;  5AJ9 A;  1E1Z P;  2X98 A;  4UOO A;  2GLQ A;  5DLW A;  3WAV A;  1E2S P;  5EGE A;  3A52 A;  5IJQ A;  1AJD A;  1N2K A;  4KJG A;  3TX0 A;  4KM4 A;  1URA A;  5EGH A;  4CYR A;  5LQQ A;  4YR1 A;  5IJS A;  3NVL A;  4GTZ A;  4UPL A;  1O99 A;  3SZZ A;  3UN3 A;  4LR7 A;  1P49 A;  1Y7A A;  1KHL A;  1AJA A;  4GTX A;  4LRE A;  5GRR A;  2W8S A;  2D1G A;  3BDG A;  1HQA A;  3UN2 A;  4KAV A;  2RH6 A;  2W5S A;  2ZKT A;  1EW2 A;  2W5T A;  1KH4 A;  2GSO A;  1EI6 A;  4UOP A;  3UNY A;  3WAY A;  1B8J A;  1ALK A;  1ZED A;  2GSU A;  4NWX A;  1ELY A;  1ZEB A;  1E33 P;  2IUC B;  2W8D A;  1KH7 A;  5TJ3 A;  2IFY A;  3NKQ A;  3WBH A;  2XRG A;  1K7H A;  3BDH A;  3NKM A;  5L0E A;  5LRM A;  3Q3Q A;  4LRC A;  1ELZ A;  1HJK A;  2GSN A;  1EW8 A;  3BDF A;  3MK1 A;  4LR2 A;  4LRF A;  4N7T A;  1HDH A;  3M8Z A;  1ALJ A;  5LIA A;  3ED4 A;  1AJB A;  3NKP A;  5DLV A;  1ZEF A;  3LXQ A;  5L0K A;  4LR9 A;  5KXA A;  4FDJ A;  1FSU A;  1ELX A;  1KHJ A;  3IDD A;  1EJJ A;  2G9Y A;  2GA3 A;  4LR8 A;  3DYC A;  4LQY A;  3NKO A;  3E2D A;  5DLT A;  4MIV A;  4ZG6 A;  2ANH A;  4LRA A;  4MHX A;  4MY4 A;  1ED8 A;  4UOR A;  3UO0 A;  2VQR A;  4QAX A;  5INH A;  1AUK A;  4ZG7 A;  2QZU A;  3M8Y A;  3BDG B;  3NKR A;  4KAY A;  2IUC A;  2W5R A;  1ALI A;  1KH9 A;  3DPC A;  3T01 A;  1ANI A;  3T00 A;  4CXU A;  5L0B A;  4KJD A;  4UPK A;  3T02 A;  3OT9 A;  4LRD A;  2W5Q A;  1O98 A;  1KHN A;  5GOV A;  3M8W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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