1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Total Genus 176
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
176
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 176
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
5L0BA 3BDGB 1ED9A 3IDDA 2W8SA 3SZZA 2W5RA 4ZGAA 2IUCA 4MIVA 4KAYA 3UN3A 4KJDA 1ZEBA 4CYRA 5HRTA 4GTXA 4GTZA 1ANIA 1KHNA 2GSNA 2W5WA 5IJQA 1KH5A 3T00A 1EW8A 1AJDA 3OT9A 4LRFA 1P49A 4QAXA 3UNYA 2VQRA 1SHNA 2XRGA 3DPCA 4LREA 3TX0A 4CXSA 4MY4A 3M8WA 4LR7A 3ED4A 5GOVA 2RH6A 4LR2A 2X98A 4UPHA 4UPIA 3WAWA 2G9YA 1URBA 1AUKA 1KH7A 3IGZB 5DLWA 1E33P 1HJKA 2W8DA 3A52A 5DLTA 4UOOA 1Y6VA 4UORA 3NKRA 4ZG9A 1EQJA 3BDHA 3LXQA 4KJGA 4LRDA 3MK1A 5AJ9A 2GA3A 4B56A 4LRBA 1KHJA 5IJSA 1EJJA 2GSUA 3Q3QA 5LRNA 5EGEA 5KXAA 5C66A 3SZYA 1O98A 4NWJA 3WAXA 3UN2A 1ED8A 3UO0A 1N2KA 2ANHA 1EW2A 4FDIA 1KHLA 4GTWA 1AJBA 2D1GA 4NWXA 1K7HA 1Y7AA 4UPKA 4KM4A 5L0KA 4YR1A 4ZG7A 4LR8A 3NKQA 3KD8A 1KHKA 1N2LA 4UPLA 1E2SP 4GTYA 1ELXA 2W5QA 3DYCA 2GLQA 3M7VA 3E2DA 5LRMA 3M8ZA 2W5SA 3NKPA 1ANJA 1E3CP 3NVLA 4KAVA 4LRCA 4N7TA 4ZG6A 1ALJA 4UOPA 1ALKA 2GSOA 3CMRA 1O99A 4LRAA 3IGYB 1EI6A 5INHA 1ZEFA 3UN5A 4LR9A 1E1ZP 1HQAA 1KH9A 5TJ3A 3WAYA 1URAA 3B5QA 2ZKTA 1AJCA 2IFYA 2W5TA 3T01A 5L0EA 3TG0A 1KH4A 3MK2A 5DLVA 1ALHA 2W5XA 2W5VA 2IUCB 3NKMA 5K4PA 4MHXA 3M8YA 3MK0A 5GRRA 2QZUA 3NKOA 5EGHA 3WBHA 3BDFA 4CXUA 1AJAA 4FDJA 1ALIA 5LQQA 5LIAA 1EW9A 1SHQA 4CYSA 3NKNA 3BDGA 3TWZA 1ELZA 1HDHA 1B8JA 3T02A 4TN0A 4CXKA 1FSUA 1ZEDA 3WAVA 1ELYA 4LQYA 2XR9A
chains in the Genus database with same CATH superfamily
5L0BA 3BDGB 1ED9A 3IDDA 2W8SA 3SZZA 2W5RA 4ZGAA 2IUCA 4MIVA 4KAYA 3UN3A 4KJDA 1ZEBA 4CYRA 5HRTA 4GTXA 4GTZA 1ANIA 1KHNA 2GSNA 2W5WA 5IJQA 1KH5A 3T00A 1EW8A 1AJDA 3OT9A 4LRFA 1P49A 4QAXA 3UNYA 2VQRA 1SHNA 2XRGA 3DPCA 4LREA 3TX0A 4CXSA 4MY4A 3M8WA 4LR7A 3ED4A 5GOVA 2RH6A 4LR2A 2X98A 4UPHA 4UPIA 3WAWA 2G9YA 1URBA 1AUKA 1KH7A 3IGZB 5DLWA 1E33P 1HJKA 2W8DA 3A52A 5DLTA 4UOOA 1Y6VA 4UORA 3NKRA 4ZG9A 1EQJA 3BDHA 3LXQA 4KJGA 4LRDA 3MK1A 5AJ9A 2GA3A 4B56A 4LRBA 1KHJA 5IJSA 1EJJA 2GSUA 3Q3QA 5LRNA 5EGEA 5KXAA 5C66A 3SZYA 1O98A 4NWJA 3WAXA 3UN2A 1ED8A 3UO0A 1N2KA 2ANHA 1EW2A 4FDIA 1KHLA 4GTWA 1AJBA 2D1GA 4NWXA 1K7HA 1Y7AA 4UPKA 4KM4A 5L0KA 4YR1A 4ZG7A 4LR8A 3NKQA 3KD8A 1KHKA 1N2LA 4UPLA 1E2SP 4GTYA 1ELXA 2W5QA 3DYCA 2GLQA 3M7VA 3E2DA 5LRMA 3M8ZA 2W5SA 3NKPA 1ANJA 1E3CP 3NVLA 4KAVA 4LRCA 4N7TA 4ZG6A 1ALJA 4UOPA 1ALKA 2GSOA 3CMRA 1O99A 4LRAA 3IGYB 1EI6A 5INHA 1ZEFA 3UN5A 4LR9A 1E1ZP 1HQAA 1KH9A 5TJ3A 3WAYA 1URAA 3B5QA 2ZKTA 1AJCA 2IFYA 2W5TA 3T01A 5L0EA 3TG0A 1KH4A 3MK2A 5DLVA 1ALHA 2W5XA 2W5VA 2IUCB 3NKMA 5K4PA 4MHXA 3M8YA 3MK0A 5GRRA 2QZUA 3NKOA 5EGHA 3WBHA 3BDFA 4CXUA 1AJAA 4FDJA 1ALIA 5LQQA 5LIAA 1EW9A 1SHQA 4CYSA 3NKNA 3BDGA 3TWZA 1ELZA 1HDHA 1B8JA 3T02A 4TN0A 4CXKA 1FSUA 1ZEDA 3WAVA 1ELYA 4LQYA 2XR9A
chains in the Genus database with same CATH topology
5L0BA 3BDGB 1ED9A 3IDDA 2W8SA 3SZZA 2W5RA 4ZGAA 2IUCA 4MIVA 4KAYA 3UN3A 4KJDA 1ZEBA 4CYRA 5HRTA 4GTXA 4GTZA 1ANIA 1KHNA 2GSNA 2W5WA 5IJQA 1KH5A 3T00A 1EW8A 1AJDA 3OT9A 4LRFA 1P49A 4QAXA 3UNYA 2VQRA 1SHNA 2XRGA 3DPCA 4LREA 3TX0A 4CXSA 4MY4A 3M8WA 4LR7A 3ED4A 5GOVA 2RH6A 4LR2A 2X98A 4UPHA 4UPIA 3WAWA 2G9YA 1URBA 1AUKA 1KH7A 3IGZB 5DLWA 1E33P 1HJKA 2W8DA 3A52A 5DLTA 4UOOA 1Y6VA 4UORA 3NKRA 4ZG9A 1EQJA 3BDHA 3LXQA 4KJGA 4LRDA 3MK1A 5AJ9A 2GA3A 4B56A 4LRBA 1KHJA 5IJSA 1EJJA 2GSUA 3Q3QA 5LRNA 5EGEA 5KXAA 5C66A 3SZYA 1O98A 4NWJA 3WAXA 3UN2A 1ED8A 3UO0A 1N2KA 2ANHA 1EW2A 4FDIA 1KHLA 4GTWA 1AJBA 2D1GA 4NWXA 1K7HA 1Y7AA 4UPKA 4KM4A 5L0KA 4YR1A 4ZG7A 4LR8A 3NKQA 3KD8A 1KHKA 1N2LA 4UPLA 1E2SP 4GTYA 1ELXA 2W5QA 3DYCA 2GLQA 3M7VA 3E2DA 5LRMA 3M8ZA 2W5SA 3NKPA 1ANJA 1E3CP 3NVLA 4KAVA 4LRCA 4N7TA 4ZG6A 1ALJA 4UOPA 1ALKA 2GSOA 3CMRA 1O99A 4LRAA 3IGYB 1EI6A 5INHA 1ZEFA 3UN5A 4LR9A 1E1ZP 1HQAA 1KH9A 5TJ3A 3WAYA 1URAA 3B5QA 2ZKTA 1AJCA 2IFYA 2W5TA 3T01A 5L0EA 3TG0A 1KH4A 3MK2A 5DLVA 1ALHA 2W5XA 2W5VA 2IUCB 3NKMA 5K4PA 4MHXA 3M8YA 3MK0A 5GRRA 2QZUA 3NKOA 5EGHA 3WBHA 3BDFA 4CXUA 1AJAA 4FDJA 1ALIA 5LQQA 5LIAA 1EW9A 1SHQA 4CYSA 3NKNA 3BDGA 3TWZA 1ELZA 1HDHA 1B8JA 3T02A 4TN0A 4CXKA 1FSUA 1ZEDA 3WAVA 1ELYA 4LQYA 2XR9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0B A;  3BDG B;  1ED9 A;  3IDD A;  2W8S A;  3SZZ A;  2W5R A;  4ZGA A;  2IUC A;  4MIV A;  4KAY A;  3UN3 A;  4KJD A;  1ZEB A;  4CYR A;  5HRT A;  4GTX A;  4GTZ A;  1ANI A;  1KHN A;  2GSN A;  2W5W A;  5IJQ A;  1KH5 A;  3T00 A;  1EW8 A;  1AJD A;  3OT9 A;  4LRF A;  1P49 A;  4QAX A;  3UNY A;  2VQR A;  1SHN A;  2XRG A;  3DPC A;  4LRE A;  3TX0 A;  4CXS A;  4MY4 A;  3M8W A;  4LR7 A;  3ED4 A;  5GOV A;  2RH6 A;  4LR2 A;  2X98 A;  4UPH A;  4UPI A;  3WAW A;  2G9Y A;  1URB A;  1AUK A;  1KH7 A;  3IGZ B;  5DLW A;  1E33 P;  1HJK A;  2W8D A;  3A52 A;  5DLT A;  4UOO A;  1Y6V A;  4UOR A;  3NKR A;  4ZG9 A;  1EQJ A;  3BDH A;  3LXQ A;  4KJG A;  4LRD A;  3MK1 A;  5AJ9 A;  2GA3 A;  4B56 A;  4LRB A;  1KHJ A;  5IJS A;  1EJJ A;  2GSU A;  3Q3Q A;  5LRN A;  5EGE A;  5KXA A;  5C66 A;  3SZY A;  1O98 A;  4NWJ A;  3WAX A;  3UN2 A;  1ED8 A;  3UO0 A;  1N2K A;  2ANH A;  1EW2 A;  4FDI A;  1KHL A;  4GTW A;  1AJB A;  2D1G A;  4NWX A;  1K7H A;  1Y7A A;  4UPK A;  4KM4 A;  5L0K A;  4YR1 A;  4ZG7 A;  4LR8 A;  3NKQ A;  3KD8 A;  1KHK A;  1N2L A;  4UPL A;  1E2S P;  4GTY A;  1ELX A;  2W5Q A;  3DYC A;  2GLQ A;  3M7V A;  3E2D A;  5LRM A;  3M8Z A;  2W5S A;  3NKP A;  1ANJ A;  1E3C P;  3NVL A;  4KAV A;  4LRC A;  4N7T A;  4ZG6 A;  1ALJ A;  4UOP A;  1ALK A;  2GSO A;  3CMR A;  1O99 A;  4LRA A;  3IGY B;  1EI6 A;  5INH A;  1ZEF A;  3UN5 A;  4LR9 A;  1E1Z P;  1HQA A;  1KH9 A;  5TJ3 A;  3WAY A;  1URA A;  3B5Q A;  2ZKT A;  1AJC A;  2IFY A;  2W5T A;  3T01 A;  5L0E A;  3TG0 A;  1KH4 A;  3MK2 A;  5DLV A;  1ALH A;  2W5X A;  2W5V A;  2IUC B;  3NKM A;  5K4P A;  4MHX A;  3M8Y A;  3MK0 A;  5GRR A;  2QZU A;  3NKO A;  5EGH A;  3WBH A;  3BDF A;  4CXU A;  1AJA A;  4FDJ A;  1ALI A;  5LQQ A;  5LIA A;  1EW9 A;  1SHQ A;  4CYS A;  3NKN A;  3BDG A;  3TWZ A;  1ELZ A;  1HDH A;  1B8J A;  3T02 A;  4TN0 A;  4CXK A;  1FSU A;  1ZED A;  3WAV A;  1ELY A;  4LQY A;  2XR9 A; 
#chains in the Genus database with same CATH topology
 5L0B A;  3BDG B;  1ED9 A;  3IDD A;  2W8S A;  3SZZ A;  2W5R A;  4ZGA A;  2IUC A;  4MIV A;  4KAY A;  3UN3 A;  4KJD A;  1ZEB A;  4CYR A;  5HRT A;  4GTX A;  4GTZ A;  1ANI A;  1KHN A;  2GSN A;  2W5W A;  5IJQ A;  1KH5 A;  3T00 A;  1EW8 A;  1AJD A;  3OT9 A;  4LRF A;  1P49 A;  4QAX A;  3UNY A;  2VQR A;  1SHN A;  2XRG A;  3DPC A;  4LRE A;  3TX0 A;  4CXS A;  4MY4 A;  3M8W A;  4LR7 A;  3ED4 A;  5GOV A;  2RH6 A;  4LR2 A;  2X98 A;  4UPH A;  4UPI A;  3WAW A;  2G9Y A;  1URB A;  1AUK A;  1KH7 A;  3IGZ B;  5DLW A;  1E33 P;  1HJK A;  2W8D A;  3A52 A;  5DLT A;  4UOO A;  1Y6V A;  4UOR A;  3NKR A;  4ZG9 A;  1EQJ A;  3BDH A;  3LXQ A;  4KJG A;  4LRD A;  3MK1 A;  5AJ9 A;  2GA3 A;  4B56 A;  4LRB A;  1KHJ A;  5IJS A;  1EJJ A;  2GSU A;  3Q3Q A;  5LRN A;  5EGE A;  5KXA A;  5C66 A;  3SZY A;  1O98 A;  4NWJ A;  3WAX A;  3UN2 A;  1ED8 A;  3UO0 A;  1N2K A;  2ANH A;  1EW2 A;  4FDI A;  1KHL A;  4GTW A;  1AJB A;  2D1G A;  4NWX A;  1K7H A;  1Y7A A;  4UPK A;  4KM4 A;  5L0K A;  4YR1 A;  4ZG7 A;  4LR8 A;  3NKQ A;  3KD8 A;  1KHK A;  1N2L A;  4UPL A;  1E2S P;  4GTY A;  1ELX A;  2W5Q A;  3DYC A;  2GLQ A;  3M7V A;  3E2D A;  5LRM A;  3M8Z A;  2W5S A;  3NKP A;  1ANJ A;  1E3C P;  3NVL A;  4KAV A;  4LRC A;  4N7T A;  4ZG6 A;  1ALJ A;  4UOP A;  1ALK A;  2GSO A;  3CMR A;  1O99 A;  4LRA A;  3IGY B;  1EI6 A;  5INH A;  1ZEF A;  3UN5 A;  4LR9 A;  1E1Z P;  1HQA A;  1KH9 A;  5TJ3 A;  3WAY A;  1URA A;  3B5Q A;  2ZKT A;  1AJC A;  2IFY A;  2W5T A;  3T01 A;  5L0E A;  3TG0 A;  1KH4 A;  3MK2 A;  5DLV A;  1ALH A;  2W5X A;  2W5V A;  2IUC B;  3NKM A;  5K4P A;  4MHX A;  3M8Y A;  3MK0 A;  5GRR A;  2QZU A;  3NKO A;  5EGH A;  3WBH A;  3BDF A;  4CXU A;  1AJA A;  4FDJ A;  1ALI A;  5LQQ A;  5LIA A;  1EW9 A;  1SHQ A;  4CYS A;  3NKN A;  3BDG A;  3TWZ A;  1ELZ A;  1HDH A;  1B8J A;  3T02 A;  4TN0 A;  4CXK A;  1FSU A;  1ZED A;  3WAV A;  1ELY A;  4LQY A;  2XR9 A; 
#chains in the Genus database with same CATH homology
 5L0B A;  3BDG B;  1ED9 A;  3IDD A;  2W8S A;  3SZZ A;  2W5R A;  4ZGA A;  2IUC A;  4MIV A;  4KAY A;  3UN3 A;  4KJD A;  1ZEB A;  4CYR A;  5HRT A;  4GTX A;  4GTZ A;  1ANI A;  1KHN A;  2GSN A;  2W5W A;  5IJQ A;  1KH5 A;  3T00 A;  1EW8 A;  1AJD A;  3OT9 A;  4LRF A;  1P49 A;  4QAX A;  3UNY A;  2VQR A;  1SHN A;  2XRG A;  3DPC A;  4LRE A;  3TX0 A;  4CXS A;  4MY4 A;  3M8W A;  4LR7 A;  3ED4 A;  5GOV A;  2RH6 A;  4LR2 A;  2X98 A;  4UPH A;  4UPI A;  3WAW A;  2G9Y A;  1URB A;  1AUK A;  1KH7 A;  3IGZ B;  5DLW A;  1E33 P;  1HJK A;  2W8D A;  3A52 A;  5DLT A;  4UOO A;  1Y6V A;  4UOR A;  3NKR A;  4ZG9 A;  1EQJ A;  3BDH A;  3LXQ A;  4KJG A;  4LRD A;  3MK1 A;  5AJ9 A;  2GA3 A;  4B56 A;  4LRB A;  1KHJ A;  5IJS A;  1EJJ A;  2GSU A;  3Q3Q A;  5LRN A;  5EGE A;  5KXA A;  5C66 A;  3SZY A;  1O98 A;  4NWJ A;  3WAX A;  3UN2 A;  1ED8 A;  3UO0 A;  1N2K A;  2ANH A;  1EW2 A;  4FDI A;  1KHL A;  4GTW A;  1AJB A;  2D1G A;  4NWX A;  1K7H A;  1Y7A A;  4UPK A;  4KM4 A;  5L0K A;  4YR1 A;  4ZG7 A;  4LR8 A;  3NKQ A;  3KD8 A;  1KHK A;  1N2L A;  4UPL A;  1E2S P;  4GTY A;  1ELX A;  2W5Q A;  3DYC A;  2GLQ A;  3M7V A;  3E2D A;  5LRM A;  3M8Z A;  2W5S A;  3NKP A;  1ANJ A;  1E3C P;  3NVL A;  4KAV A;  4LRC A;  4N7T A;  4ZG6 A;  1ALJ A;  4UOP A;  1ALK A;  2GSO A;  3CMR A;  1O99 A;  4LRA A;  3IGY B;  1EI6 A;  5INH A;  1ZEF A;  3UN5 A;  4LR9 A;  1E1Z P;  1HQA A;  1KH9 A;  5TJ3 A;  3WAY A;  1URA A;  3B5Q A;  2ZKT A;  1AJC A;  2IFY A;  2W5T A;  3T01 A;  5L0E A;  3TG0 A;  1KH4 A;  3MK2 A;  5DLV A;  1ALH A;  2W5X A;  2W5V A;  2IUC B;  3NKM A;  5K4P A;  4MHX A;  3M8Y A;  3MK0 A;  5GRR A;  2QZU A;  3NKO A;  5EGH A;  3WBH A;  3BDF A;  4CXU A;  1AJA A;  4FDJ A;  1ALI A;  5LQQ A;  5LIA A;  1EW9 A;  1SHQ A;  4CYS A;  3NKN A;  3BDG A;  3TWZ A;  1ELZ A;  1HDH A;  1B8J A;  3T02 A;  4TN0 A;  4CXK A;  1FSU A;  1ZED A;  3WAV A;  1ELY A;  4LQY A;  2XR9 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...