1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Non specific mono-esterase
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
4FDJA 5L0BA 4TN0A 3T01A 2GLQA 3M7VA 1SHQA 4UPKA 2W8DA 1AUKA 3UO0A 5LRMA 4UPIA 1N2LA 4QAXA 1EI6A 2IUCA 5DLTA 1E2SP 1ELZA 4KM4A 3M8ZA 2X98A 5LIAA 4ZG6A 1B8JA 3WAVA 4KJGA 4KAYA 1KHLA 3CMRA 3M8WA 1Y7AA 5L0KA 1O98A 4LR9A 4CYSA 1KHKA 1HDHA 1KHJA 4UPLA 3WAWA 4CXKA 4LRCA 1Y6VA 3MK2A 3E2DA 4ZGAA 1AJCA 2GSUA 4LRBA 3KD8A 1K7HA 4UOPA 2W5VA 5GRRA 1N2KA 2GSNA 1ELYA 4NWXA 1ANIA 2IUCB 2GSOA 1ZEDA 3NKPA 3UNYA 1AJAA 5LQQA 1ALKA 3BDFA 3ED4A 1URBA 4LR2A 4UOOA 5L0EA 3M8YA 3B5QA 3DPCA 1EW8A 4ZG7A 4MIVA 1KH5A 4LREA 4LRDA 5DLWA 1E1ZP 2VQRA 4GTWA 1ALJA 2W5RA 1ED9A 2RH6A 3IGZB 3IGYB 5TJ3A 3UN5A 5IJQA 3NKQA 4FDIA 4UORA 4UPHA 4LR8A 3NKOA 4GTZA 4CYRA 4N7TA 1KH4A 1ZEBA 1KH9A 4YR1A 2G9YA 4MHXA 3NKRA 1HQAA 3TWZA 3OT9A 5KXAA 1KHNA 3TG0A 2W5XA 2ANHA 2D1GA 5AJ9A 1ELXA 1EW2A 2XR9A 4GTYA 1EW9A 4NWJA 4LQYA 1O99A 3NVLA 3WAXA 2IFYA 1HJKA 3NKMA 1ALHA 2XRGA 2W5QA 3BDHA 1ANJA 3LXQA 1E3CP 4LR7A 4LRAA 3T00A 1ZEFA 5HRTA 1AJDA 5EGEA 5DLVA 1SHNA 1P49A 5INHA 2W5TA 3IDDA 3TX0A 4LRFA 3WBHA 3A52A 5GOVA 4B56A 3UN3A 4GTXA 3MK1A 4KJDA 5C66A 3MK0A 2W5SA 4ZG9A 1EJJA 3WAYA 4MY4A 1KH7A 1AJBA 1EQJA 1ALIA 1ED8A 1FSUA 3Q3QA 2ZKTA 1E33P 4CXUA 1URAA 3NKNA 3BDGB 5EGHA 4KAVA 3SZYA 3SZZA 5K4PA 5LRNA 2GA3A 3DYCA 3BDGA 2QZUA 5IJSA 4CXSA 3UN2A 3T02A 2W5WA 2W8SA
chains in the Genus database with same CATH superfamily
4FDJA 5L0BA 4TN0A 3T01A 2GLQA 3M7VA 1SHQA 4UPKA 2W8DA 1AUKA 3UO0A 5LRMA 4UPIA 1N2LA 4QAXA 1EI6A 2IUCA 5DLTA 1E2SP 1ELZA 4KM4A 3M8ZA 2X98A 5LIAA 4ZG6A 1B8JA 3WAVA 4KJGA 4KAYA 1KHLA 3CMRA 3M8WA 1Y7AA 5L0KA 1O98A 4LR9A 4CYSA 1KHKA 1HDHA 1KHJA 4UPLA 3WAWA 4CXKA 4LRCA 1Y6VA 3MK2A 3E2DA 4ZGAA 1AJCA 2GSUA 4LRBA 3KD8A 1K7HA 4UOPA 2W5VA 5GRRA 1N2KA 2GSNA 1ELYA 4NWXA 1ANIA 2IUCB 2GSOA 1ZEDA 3NKPA 3UNYA 1AJAA 5LQQA 1ALKA 3BDFA 3ED4A 1URBA 4LR2A 4UOOA 5L0EA 3M8YA 3B5QA 3DPCA 1EW8A 4ZG7A 4MIVA 1KH5A 4LREA 4LRDA 5DLWA 1E1ZP 2VQRA 4GTWA 1ALJA 2W5RA 1ED9A 2RH6A 3IGZB 3IGYB 5TJ3A 3UN5A 5IJQA 3NKQA 4FDIA 4UORA 4UPHA 4LR8A 3NKOA 4GTZA 4CYRA 4N7TA 1KH4A 1ZEBA 1KH9A 4YR1A 2G9YA 4MHXA 3NKRA 1HQAA 3TWZA 3OT9A 5KXAA 1KHNA 3TG0A 2W5XA 2ANHA 2D1GA 5AJ9A 1ELXA 1EW2A 2XR9A 4GTYA 1EW9A 4NWJA 4LQYA 1O99A 3NVLA 3WAXA 2IFYA 1HJKA 3NKMA 1ALHA 2XRGA 2W5QA 3BDHA 1ANJA 3LXQA 1E3CP 4LR7A 4LRAA 3T00A 1ZEFA 5HRTA 1AJDA 5EGEA 5DLVA 1SHNA 1P49A 5INHA 2W5TA 3IDDA 3TX0A 4LRFA 3WBHA 3A52A 5GOVA 4B56A 3UN3A 4GTXA 3MK1A 4KJDA 5C66A 3MK0A 2W5SA 4ZG9A 1EJJA 3WAYA 4MY4A 1KH7A 1AJBA 1EQJA 1ALIA 1ED8A 1FSUA 3Q3QA 2ZKTA 1E33P 4CXUA 1URAA 3NKNA 3BDGB 5EGHA 4KAVA 3SZYA 3SZZA 5K4PA 5LRNA 2GA3A 3DYCA 3BDGA 2QZUA 5IJSA 4CXSA 3UN2A 3T02A 2W5WA 2W8SA
chains in the Genus database with same CATH topology
4FDJA 5L0BA 4TN0A 3T01A 2GLQA 3M7VA 1SHQA 4UPKA 2W8DA 1AUKA 3UO0A 5LRMA 4UPIA 1N2LA 4QAXA 1EI6A 2IUCA 5DLTA 1E2SP 1ELZA 4KM4A 3M8ZA 2X98A 5LIAA 4ZG6A 1B8JA 3WAVA 4KJGA 4KAYA 1KHLA 3CMRA 3M8WA 1Y7AA 5L0KA 1O98A 4LR9A 4CYSA 1KHKA 1HDHA 1KHJA 4UPLA 3WAWA 4CXKA 4LRCA 1Y6VA 3MK2A 3E2DA 4ZGAA 1AJCA 2GSUA 4LRBA 3KD8A 1K7HA 4UOPA 2W5VA 5GRRA 1N2KA 2GSNA 1ELYA 4NWXA 1ANIA 2IUCB 2GSOA 1ZEDA 3NKPA 3UNYA 1AJAA 5LQQA 1ALKA 3BDFA 3ED4A 1URBA 4LR2A 4UOOA 5L0EA 3M8YA 3B5QA 3DPCA 1EW8A 4ZG7A 4MIVA 1KH5A 4LREA 4LRDA 5DLWA 1E1ZP 2VQRA 4GTWA 1ALJA 2W5RA 1ED9A 2RH6A 3IGZB 3IGYB 5TJ3A 3UN5A 5IJQA 3NKQA 4FDIA 4UORA 4UPHA 4LR8A 3NKOA 4GTZA 4CYRA 4N7TA 1KH4A 1ZEBA 1KH9A 4YR1A 2G9YA 4MHXA 3NKRA 1HQAA 3TWZA 3OT9A 5KXAA 1KHNA 3TG0A 2W5XA 2ANHA 2D1GA 5AJ9A 1ELXA 1EW2A 2XR9A 4GTYA 1EW9A 4NWJA 4LQYA 1O99A 3NVLA 3WAXA 2IFYA 1HJKA 3NKMA 1ALHA 2XRGA 2W5QA 3BDHA 1ANJA 3LXQA 1E3CP 4LR7A 4LRAA 3T00A 1ZEFA 5HRTA 1AJDA 5EGEA 5DLVA 1SHNA 1P49A 5INHA 2W5TA 3IDDA 3TX0A 4LRFA 3WBHA 3A52A 5GOVA 4B56A 3UN3A 4GTXA 3MK1A 4KJDA 5C66A 3MK0A 2W5SA 4ZG9A 1EJJA 3WAYA 4MY4A 1KH7A 1AJBA 1EQJA 1ALIA 1ED8A 1FSUA 3Q3QA 2ZKTA 1E33P 4CXUA 1URAA 3NKNA 3BDGB 5EGHA 4KAVA 3SZYA 3SZZA 5K4PA 5LRNA 2GA3A 3DYCA 3BDGA 2QZUA 5IJSA 4CXSA 3UN2A 3T02A 2W5WA 2W8SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDJ A;  5L0B A;  4TN0 A;  3T01 A;  2GLQ A;  3M7V A;  1SHQ A;  4UPK A;  2W8D A;  1AUK A;  3UO0 A;  5LRM A;  4UPI A;  1N2L A;  4QAX A;  1EI6 A;  2IUC A;  5DLT A;  1E2S P;  1ELZ A;  4KM4 A;  3M8Z A;  2X98 A;  5LIA A;  4ZG6 A;  1B8J A;  3WAV A;  4KJG A;  4KAY A;  1KHL A;  3CMR A;  3M8W A;  1Y7A A;  5L0K A;  1O98 A;  4LR9 A;  4CYS A;  1KHK A;  1HDH A;  1KHJ A;  4UPL A;  3WAW A;  4CXK A;  4LRC A;  1Y6V A;  3MK2 A;  3E2D A;  4ZGA A;  1AJC A;  2GSU A;  4LRB A;  3KD8 A;  1K7H A;  4UOP A;  2W5V A;  5GRR A;  1N2K A;  2GSN A;  1ELY A;  4NWX A;  1ANI A;  2IUC B;  2GSO A;  1ZED A;  3NKP A;  3UNY A;  1AJA A;  5LQQ A;  1ALK A;  3BDF A;  3ED4 A;  1URB A;  4LR2 A;  4UOO A;  5L0E A;  3M8Y A;  3B5Q A;  3DPC A;  1EW8 A;  4ZG7 A;  4MIV A;  1KH5 A;  4LRE A;  4LRD A;  5DLW A;  1E1Z P;  2VQR A;  4GTW A;  1ALJ A;  2W5R A;  1ED9 A;  2RH6 A;  3IGZ B;  3IGY B;  5TJ3 A;  3UN5 A;  5IJQ A;  3NKQ A;  4FDI A;  4UOR A;  4UPH A;  4LR8 A;  3NKO A;  4GTZ A;  4CYR A;  4N7T A;  1KH4 A;  1ZEB A;  1KH9 A;  4YR1 A;  2G9Y A;  4MHX A;  3NKR A;  1HQA A;  3TWZ A;  3OT9 A;  5KXA A;  1KHN A;  3TG0 A;  2W5X A;  2ANH A;  2D1G A;  5AJ9 A;  1ELX A;  1EW2 A;  2XR9 A;  4GTY A;  1EW9 A;  4NWJ A;  4LQY A;  1O99 A;  3NVL A;  3WAX A;  2IFY A;  1HJK A;  3NKM A;  1ALH A;  2XRG A;  2W5Q A;  3BDH A;  1ANJ A;  3LXQ A;  1E3C P;  4LR7 A;  4LRA A;  3T00 A;  1ZEF A;  5HRT A;  1AJD A;  5EGE A;  5DLV A;  1SHN A;  1P49 A;  5INH A;  2W5T A;  3IDD A;  3TX0 A;  4LRF A;  3WBH A;  3A52 A;  5GOV A;  4B56 A;  3UN3 A;  4GTX A;  3MK1 A;  4KJD A;  5C66 A;  3MK0 A;  2W5S A;  4ZG9 A;  1EJJ A;  3WAY A;  4MY4 A;  1KH7 A;  1AJB A;  1EQJ A;  1ALI A;  1ED8 A;  1FSU A;  3Q3Q A;  2ZKT A;  1E33 P;  4CXU A;  1URA A;  3NKN A;  3BDG B;  5EGH A;  4KAV A;  3SZY A;  3SZZ A;  5K4P A;  5LRN A;  2GA3 A;  3DYC A;  3BDG A;  2QZU A;  5IJS A;  4CXS A;  3UN2 A;  3T02 A;  2W5W A;  2W8S A; 
#chains in the Genus database with same CATH topology
 4FDJ A;  5L0B A;  4TN0 A;  3T01 A;  2GLQ A;  3M7V A;  1SHQ A;  4UPK A;  2W8D A;  1AUK A;  3UO0 A;  5LRM A;  4UPI A;  1N2L A;  4QAX A;  1EI6 A;  2IUC A;  5DLT A;  1E2S P;  1ELZ A;  4KM4 A;  3M8Z A;  2X98 A;  5LIA A;  4ZG6 A;  1B8J A;  3WAV A;  4KJG A;  4KAY A;  1KHL A;  3CMR A;  3M8W A;  1Y7A A;  5L0K A;  1O98 A;  4LR9 A;  4CYS A;  1KHK A;  1HDH A;  1KHJ A;  4UPL A;  3WAW A;  4CXK A;  4LRC A;  1Y6V A;  3MK2 A;  3E2D A;  4ZGA A;  1AJC A;  2GSU A;  4LRB A;  3KD8 A;  1K7H A;  4UOP A;  2W5V A;  5GRR A;  1N2K A;  2GSN A;  1ELY A;  4NWX A;  1ANI A;  2IUC B;  2GSO A;  1ZED A;  3NKP A;  3UNY A;  1AJA A;  5LQQ A;  1ALK A;  3BDF A;  3ED4 A;  1URB A;  4LR2 A;  4UOO A;  5L0E A;  3M8Y A;  3B5Q A;  3DPC A;  1EW8 A;  4ZG7 A;  4MIV A;  1KH5 A;  4LRE A;  4LRD A;  5DLW A;  1E1Z P;  2VQR A;  4GTW A;  1ALJ A;  2W5R A;  1ED9 A;  2RH6 A;  3IGZ B;  3IGY B;  5TJ3 A;  3UN5 A;  5IJQ A;  3NKQ A;  4FDI A;  4UOR A;  4UPH A;  4LR8 A;  3NKO A;  4GTZ A;  4CYR A;  4N7T A;  1KH4 A;  1ZEB A;  1KH9 A;  4YR1 A;  2G9Y A;  4MHX A;  3NKR A;  1HQA A;  3TWZ A;  3OT9 A;  5KXA A;  1KHN A;  3TG0 A;  2W5X A;  2ANH A;  2D1G A;  5AJ9 A;  1ELX A;  1EW2 A;  2XR9 A;  4GTY A;  1EW9 A;  4NWJ A;  4LQY A;  1O99 A;  3NVL A;  3WAX A;  2IFY A;  1HJK A;  3NKM A;  1ALH A;  2XRG A;  2W5Q A;  3BDH A;  1ANJ A;  3LXQ A;  1E3C P;  4LR7 A;  4LRA A;  3T00 A;  1ZEF A;  5HRT A;  1AJD A;  5EGE A;  5DLV A;  1SHN A;  1P49 A;  5INH A;  2W5T A;  3IDD A;  3TX0 A;  4LRF A;  3WBH A;  3A52 A;  5GOV A;  4B56 A;  3UN3 A;  4GTX A;  3MK1 A;  4KJD A;  5C66 A;  3MK0 A;  2W5S A;  4ZG9 A;  1EJJ A;  3WAY A;  4MY4 A;  1KH7 A;  1AJB A;  1EQJ A;  1ALI A;  1ED8 A;  1FSU A;  3Q3Q A;  2ZKT A;  1E33 P;  4CXU A;  1URA A;  3NKN A;  3BDG B;  5EGH A;  4KAV A;  3SZY A;  3SZZ A;  5K4P A;  5LRN A;  2GA3 A;  3DYC A;  3BDG A;  2QZU A;  5IJS A;  4CXS A;  3UN2 A;  3T02 A;  2W5W A;  2W8S A; 
#chains in the Genus database with same CATH homology
 4FDJ A;  5L0B A;  4TN0 A;  3T01 A;  2GLQ A;  3M7V A;  1SHQ A;  4UPK A;  2W8D A;  1AUK A;  3UO0 A;  5LRM A;  4UPI A;  1N2L A;  4QAX A;  1EI6 A;  2IUC A;  5DLT A;  1E2S P;  1ELZ A;  4KM4 A;  3M8Z A;  2X98 A;  5LIA A;  4ZG6 A;  1B8J A;  3WAV A;  4KJG A;  4KAY A;  1KHL A;  3CMR A;  3M8W A;  1Y7A A;  5L0K A;  1O98 A;  4LR9 A;  4CYS A;  1KHK A;  1HDH A;  1KHJ A;  4UPL A;  3WAW A;  4CXK A;  4LRC A;  1Y6V A;  3MK2 A;  3E2D A;  4ZGA A;  1AJC A;  2GSU A;  4LRB A;  3KD8 A;  1K7H A;  4UOP A;  2W5V A;  5GRR A;  1N2K A;  2GSN A;  1ELY A;  4NWX A;  1ANI A;  2IUC B;  2GSO A;  1ZED A;  3NKP A;  3UNY A;  1AJA A;  5LQQ A;  1ALK A;  3BDF A;  3ED4 A;  1URB A;  4LR2 A;  4UOO A;  5L0E A;  3M8Y A;  3B5Q A;  3DPC A;  1EW8 A;  4ZG7 A;  4MIV A;  1KH5 A;  4LRE A;  4LRD A;  5DLW A;  1E1Z P;  2VQR A;  4GTW A;  1ALJ A;  2W5R A;  1ED9 A;  2RH6 A;  3IGZ B;  3IGY B;  5TJ3 A;  3UN5 A;  5IJQ A;  3NKQ A;  4FDI A;  4UOR A;  4UPH A;  4LR8 A;  3NKO A;  4GTZ A;  4CYR A;  4N7T A;  1KH4 A;  1ZEB A;  1KH9 A;  4YR1 A;  2G9Y A;  4MHX A;  3NKR A;  1HQA A;  3TWZ A;  3OT9 A;  5KXA A;  1KHN A;  3TG0 A;  2W5X A;  2ANH A;  2D1G A;  5AJ9 A;  1ELX A;  1EW2 A;  2XR9 A;  4GTY A;  1EW9 A;  4NWJ A;  4LQY A;  1O99 A;  3NVL A;  3WAX A;  2IFY A;  1HJK A;  3NKM A;  1ALH A;  2XRG A;  2W5Q A;  3BDH A;  1ANJ A;  3LXQ A;  1E3C P;  4LR7 A;  4LRA A;  3T00 A;  1ZEF A;  5HRT A;  1AJD A;  5EGE A;  5DLV A;  1SHN A;  1P49 A;  5INH A;  2W5T A;  3IDD A;  3TX0 A;  4LRF A;  3WBH A;  3A52 A;  5GOV A;  4B56 A;  3UN3 A;  4GTX A;  3MK1 A;  4KJD A;  5C66 A;  3MK0 A;  2W5S A;  4ZG9 A;  1EJJ A;  3WAY A;  4MY4 A;  1KH7 A;  1AJB A;  1EQJ A;  1ALI A;  1ED8 A;  1FSU A;  3Q3Q A;  2ZKT A;  1E33 P;  4CXU A;  1URA A;  3NKN A;  3BDG B;  5EGH A;  4KAV A;  3SZY A;  3SZZ A;  5K4P A;  5LRN A;  2GA3 A;  3DYC A;  3BDG A;  2QZU A;  5IJS A;  4CXS A;  3UN2 A;  3T02 A;  2W5W A;  2W8S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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