1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
3WAWA 5LRMA 5L0EA 4GTYA 2W8SA 4ZG9A 2W5RA 3DYCA 1E33P 2GSUA 3B5QA 4KM4A 4QAXA 5DLVA 1EI6A 2GSNA 4GTWA 2ANHA 2VQRA 5LIAA 5INHA 2QZUA 3BDHA 4LR8A 5LRNA 1AJCA 3UN5A 3T02A 1AJAA 1ZEFA 3MK1A 2RH6A 4ZGAA 1E3CP 2XR9A 1B8JA 3NVLA 3M7VA 5GRRA 3M8ZA 1ELZA 4LR2A 4LRCA 3UN3A 4KJDA 1ALKA 2D1GA 2W8DA 2W5QA 2G9YA 3OT9A 4GTXA 1URAA 1ALJA 3NKOA 1KH7A 5LQQA 1P49A 4TN0A 4UOOA 1Y6VA 3CMRA 3BDFA 4LRDA 4LRBA 1ANJA 1ANIA 3BDGA 3UO0A 3DPCA 1HQAA 3WBHA 3SZYA 3LXQA 3T01A 1AJBA 3NKMA 4UOPA 4KJGA 3ED4A 1ALIA 4N7TA 1KHNA 3TWZA 5KXAA 4UPHA 1ZEDA 1AUKA 2IFYA 1EW8A 4ZG7A 5L0BA 1ELYA 4UORA 5AJ9A 3MK0A 1ED8A 4CYSA 2IUCA 4LREA 1KH5A 5L0KA 4KAYA 2ZKTA 1KH9A 1SHNA 3NKPA 4LR9A 2W5VA 4MIVA 5IJQA 1ELXA 4NWXA 3KD8A 1EJJA 1KHLA 5EGHA 3TX0A 4FDJA 1ZEBA 5HRTA 2W5WA 3M8WA 1K7HA 4MY4A 2X98A 4GTZA 4CXKA 5EGEA 5GOVA 3A52A 1KHKA 4UPLA 3IGZB 1N2LA 4UPIA 4ZG6A 4YR1A 3Q3QA 1O98A 5TJ3A 3SZZA 2GSOA 1KH4A 4LRAA 1ALHA 1SHQA 3T00A 3BDGB 4UPKA 5IJSA 2XRGA 3WAXA 1ED9A 3WAYA 4FDIA 4CYRA 4KAVA 3M8YA 1FSUA 3MK2A 3NKNA 3IDDA 1AJDA 1O99A 1E1ZP 1N2KA 4CXSA 2W5SA 3E2DA 3NKQA 1URBA 2W5XA 4B56A 1KHJA 1EW2A 3UN2A 2IUCB 2W5TA 5K4PA 5DLWA 2GLQA 1EW9A 3UNYA 4CXUA 5C66A 1HJKA 1Y7AA 3IGYB 5DLTA 3TG0A 4LRFA 4MHXA 4NWJA 1E2SP 1EQJA 1HDHA 3NKRA 4LR7A 2GA3A 4LQYA 3WAVA
chains in the Genus database with same CATH superfamily
3WAWA 5LRMA 5L0EA 4GTYA 2W8SA 4ZG9A 2W5RA 3DYCA 1E33P 2GSUA 3B5QA 4KM4A 4QAXA 5DLVA 1EI6A 2GSNA 4GTWA 2ANHA 2VQRA 5LIAA 5INHA 2QZUA 3BDHA 4LR8A 5LRNA 1AJCA 3UN5A 3T02A 1AJAA 1ZEFA 3MK1A 2RH6A 4ZGAA 1E3CP 2XR9A 1B8JA 3NVLA 3M7VA 5GRRA 3M8ZA 1ELZA 4LR2A 4LRCA 3UN3A 4KJDA 1ALKA 2D1GA 2W8DA 2W5QA 2G9YA 3OT9A 4GTXA 1URAA 1ALJA 3NKOA 1KH7A 5LQQA 1P49A 4TN0A 4UOOA 1Y6VA 3CMRA 3BDFA 4LRDA 4LRBA 1ANJA 1ANIA 3BDGA 3UO0A 3DPCA 1HQAA 3WBHA 3SZYA 3LXQA 3T01A 1AJBA 3NKMA 4UOPA 4KJGA 3ED4A 1ALIA 4N7TA 1KHNA 3TWZA 5KXAA 4UPHA 1ZEDA 1AUKA 2IFYA 1EW8A 4ZG7A 5L0BA 1ELYA 4UORA 5AJ9A 3MK0A 1ED8A 4CYSA 2IUCA 4LREA 1KH5A 5L0KA 4KAYA 2ZKTA 1KH9A 1SHNA 3NKPA 4LR9A 2W5VA 4MIVA 5IJQA 1ELXA 4NWXA 3KD8A 1EJJA 1KHLA 5EGHA 3TX0A 4FDJA 1ZEBA 5HRTA 2W5WA 3M8WA 1K7HA 4MY4A 2X98A 4GTZA 4CXKA 5EGEA 5GOVA 3A52A 1KHKA 4UPLA 3IGZB 1N2LA 4UPIA 4ZG6A 4YR1A 3Q3QA 1O98A 5TJ3A 3SZZA 2GSOA 1KH4A 4LRAA 1ALHA 1SHQA 3T00A 3BDGB 4UPKA 5IJSA 2XRGA 3WAXA 1ED9A 3WAYA 4FDIA 4CYRA 4KAVA 3M8YA 1FSUA 3MK2A 3NKNA 3IDDA 1AJDA 1O99A 1E1ZP 1N2KA 4CXSA 2W5SA 3E2DA 3NKQA 1URBA 2W5XA 4B56A 1KHJA 1EW2A 3UN2A 2IUCB 2W5TA 5K4PA 5DLWA 2GLQA 1EW9A 3UNYA 4CXUA 5C66A 1HJKA 1Y7AA 3IGYB 5DLTA 3TG0A 4LRFA 4MHXA 4NWJA 1E2SP 1EQJA 1HDHA 3NKRA 4LR7A 2GA3A 4LQYA 3WAVA
chains in the Genus database with same CATH topology
3WAWA 5LRMA 5L0EA 4GTYA 2W8SA 4ZG9A 2W5RA 3DYCA 1E33P 2GSUA 3B5QA 4KM4A 4QAXA 5DLVA 1EI6A 2GSNA 4GTWA 2ANHA 2VQRA 5LIAA 5INHA 2QZUA 3BDHA 4LR8A 5LRNA 1AJCA 3UN5A 3T02A 1AJAA 1ZEFA 3MK1A 2RH6A 4ZGAA 1E3CP 2XR9A 1B8JA 3NVLA 3M7VA 5GRRA 3M8ZA 1ELZA 4LR2A 4LRCA 3UN3A 4KJDA 1ALKA 2D1GA 2W8DA 2W5QA 2G9YA 3OT9A 4GTXA 1URAA 1ALJA 3NKOA 1KH7A 5LQQA 1P49A 4TN0A 4UOOA 1Y6VA 3CMRA 3BDFA 4LRDA 4LRBA 1ANJA 1ANIA 3BDGA 3UO0A 3DPCA 1HQAA 3WBHA 3SZYA 3LXQA 3T01A 1AJBA 3NKMA 4UOPA 4KJGA 3ED4A 1ALIA 4N7TA 1KHNA 3TWZA 5KXAA 4UPHA 1ZEDA 1AUKA 2IFYA 1EW8A 4ZG7A 5L0BA 1ELYA 4UORA 5AJ9A 3MK0A 1ED8A 4CYSA 2IUCA 4LREA 1KH5A 5L0KA 4KAYA 2ZKTA 1KH9A 1SHNA 3NKPA 4LR9A 2W5VA 4MIVA 5IJQA 1ELXA 4NWXA 3KD8A 1EJJA 1KHLA 5EGHA 3TX0A 4FDJA 1ZEBA 5HRTA 2W5WA 3M8WA 1K7HA 4MY4A 2X98A 4GTZA 4CXKA 5EGEA 5GOVA 3A52A 1KHKA 4UPLA 3IGZB 1N2LA 4UPIA 4ZG6A 4YR1A 3Q3QA 1O98A 5TJ3A 3SZZA 2GSOA 1KH4A 4LRAA 1ALHA 1SHQA 3T00A 3BDGB 4UPKA 5IJSA 2XRGA 3WAXA 1ED9A 3WAYA 4FDIA 4CYRA 4KAVA 3M8YA 1FSUA 3MK2A 3NKNA 3IDDA 1AJDA 1O99A 1E1ZP 1N2KA 4CXSA 2W5SA 3E2DA 3NKQA 1URBA 2W5XA 4B56A 1KHJA 1EW2A 3UN2A 2IUCB 2W5TA 5K4PA 5DLWA 2GLQA 1EW9A 3UNYA 4CXUA 5C66A 1HJKA 1Y7AA 3IGYB 5DLTA 3TG0A 4LRFA 4MHXA 4NWJA 1E2SP 1EQJA 1HDHA 3NKRA 4LR7A 2GA3A 4LQYA 3WAVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WAW A;  5LRM A;  5L0E A;  4GTY A;  2W8S A;  4ZG9 A;  2W5R A;  3DYC A;  1E33 P;  2GSU A;  3B5Q A;  4KM4 A;  4QAX A;  5DLV A;  1EI6 A;  2GSN A;  4GTW A;  2ANH A;  2VQR A;  5LIA A;  5INH A;  2QZU A;  3BDH A;  4LR8 A;  5LRN A;  1AJC A;  3UN5 A;  3T02 A;  1AJA A;  1ZEF A;  3MK1 A;  2RH6 A;  4ZGA A;  1E3C P;  2XR9 A;  1B8J A;  3NVL A;  3M7V A;  5GRR A;  3M8Z A;  1ELZ A;  4LR2 A;  4LRC A;  3UN3 A;  4KJD A;  1ALK A;  2D1G A;  2W8D A;  2W5Q A;  2G9Y A;  3OT9 A;  4GTX A;  1URA A;  1ALJ A;  3NKO A;  1KH7 A;  5LQQ A;  1P49 A;  4TN0 A;  4UOO A;  1Y6V A;  3CMR A;  3BDF A;  4LRD A;  4LRB A;  1ANJ A;  1ANI A;  3BDG A;  3UO0 A;  3DPC A;  1HQA A;  3WBH A;  3SZY A;  3LXQ A;  3T01 A;  1AJB A;  3NKM A;  4UOP A;  4KJG A;  3ED4 A;  1ALI A;  4N7T A;  1KHN A;  3TWZ A;  5KXA A;  4UPH A;  1ZED A;  1AUK A;  2IFY A;  1EW8 A;  4ZG7 A;  5L0B A;  1ELY A;  4UOR A;  5AJ9 A;  3MK0 A;  1ED8 A;  4CYS A;  2IUC A;  4LRE A;  1KH5 A;  5L0K A;  4KAY A;  2ZKT A;  1KH9 A;  1SHN A;  3NKP A;  4LR9 A;  2W5V A;  4MIV A;  5IJQ A;  1ELX A;  4NWX A;  3KD8 A;  1EJJ A;  1KHL A;  5EGH A;  3TX0 A;  4FDJ A;  1ZEB A;  5HRT A;  2W5W A;  3M8W A;  1K7H A;  4MY4 A;  2X98 A;  4GTZ A;  4CXK A;  5EGE A;  5GOV A;  3A52 A;  1KHK A;  4UPL A;  3IGZ B;  1N2L A;  4UPI A;  4ZG6 A;  4YR1 A;  3Q3Q A;  1O98 A;  5TJ3 A;  3SZZ A;  2GSO A;  1KH4 A;  4LRA A;  1ALH A;  1SHQ A;  3T00 A;  3BDG B;  4UPK A;  5IJS A;  2XRG A;  3WAX A;  1ED9 A;  3WAY A;  4FDI A;  4CYR A;  4KAV A;  3M8Y A;  1FSU A;  3MK2 A;  3NKN A;  3IDD A;  1AJD A;  1O99 A;  1E1Z P;  1N2K A;  4CXS A;  2W5S A;  3E2D A;  3NKQ A;  1URB A;  2W5X A;  4B56 A;  1KHJ A;  1EW2 A;  3UN2 A;  2IUC B;  2W5T A;  5K4P A;  5DLW A;  2GLQ A;  1EW9 A;  3UNY A;  4CXU A;  5C66 A;  1HJK A;  1Y7A A;  3IGY B;  5DLT A;  3TG0 A;  4LRF A;  4MHX A;  4NWJ A;  1E2S P;  1EQJ A;  1HDH A;  3NKR A;  4LR7 A;  2GA3 A;  4LQY A;  3WAV A; 
#chains in the Genus database with same CATH topology
 3WAW A;  5LRM A;  5L0E A;  4GTY A;  2W8S A;  4ZG9 A;  2W5R A;  3DYC A;  1E33 P;  2GSU A;  3B5Q A;  4KM4 A;  4QAX A;  5DLV A;  1EI6 A;  2GSN A;  4GTW A;  2ANH A;  2VQR A;  5LIA A;  5INH A;  2QZU A;  3BDH A;  4LR8 A;  5LRN A;  1AJC A;  3UN5 A;  3T02 A;  1AJA A;  1ZEF A;  3MK1 A;  2RH6 A;  4ZGA A;  1E3C P;  2XR9 A;  1B8J A;  3NVL A;  3M7V A;  5GRR A;  3M8Z A;  1ELZ A;  4LR2 A;  4LRC A;  3UN3 A;  4KJD A;  1ALK A;  2D1G A;  2W8D A;  2W5Q A;  2G9Y A;  3OT9 A;  4GTX A;  1URA A;  1ALJ A;  3NKO A;  1KH7 A;  5LQQ A;  1P49 A;  4TN0 A;  4UOO A;  1Y6V A;  3CMR A;  3BDF A;  4LRD A;  4LRB A;  1ANJ A;  1ANI A;  3BDG A;  3UO0 A;  3DPC A;  1HQA A;  3WBH A;  3SZY A;  3LXQ A;  3T01 A;  1AJB A;  3NKM A;  4UOP A;  4KJG A;  3ED4 A;  1ALI A;  4N7T A;  1KHN A;  3TWZ A;  5KXA A;  4UPH A;  1ZED A;  1AUK A;  2IFY A;  1EW8 A;  4ZG7 A;  5L0B A;  1ELY A;  4UOR A;  5AJ9 A;  3MK0 A;  1ED8 A;  4CYS A;  2IUC A;  4LRE A;  1KH5 A;  5L0K A;  4KAY A;  2ZKT A;  1KH9 A;  1SHN A;  3NKP A;  4LR9 A;  2W5V A;  4MIV A;  5IJQ A;  1ELX A;  4NWX A;  3KD8 A;  1EJJ A;  1KHL A;  5EGH A;  3TX0 A;  4FDJ A;  1ZEB A;  5HRT A;  2W5W A;  3M8W A;  1K7H A;  4MY4 A;  2X98 A;  4GTZ A;  4CXK A;  5EGE A;  5GOV A;  3A52 A;  1KHK A;  4UPL A;  3IGZ B;  1N2L A;  4UPI A;  4ZG6 A;  4YR1 A;  3Q3Q A;  1O98 A;  5TJ3 A;  3SZZ A;  2GSO A;  1KH4 A;  4LRA A;  1ALH A;  1SHQ A;  3T00 A;  3BDG B;  4UPK A;  5IJS A;  2XRG A;  3WAX A;  1ED9 A;  3WAY A;  4FDI A;  4CYR A;  4KAV A;  3M8Y A;  1FSU A;  3MK2 A;  3NKN A;  3IDD A;  1AJD A;  1O99 A;  1E1Z P;  1N2K A;  4CXS A;  2W5S A;  3E2D A;  3NKQ A;  1URB A;  2W5X A;  4B56 A;  1KHJ A;  1EW2 A;  3UN2 A;  2IUC B;  2W5T A;  5K4P A;  5DLW A;  2GLQ A;  1EW9 A;  3UNY A;  4CXU A;  5C66 A;  1HJK A;  1Y7A A;  3IGY B;  5DLT A;  3TG0 A;  4LRF A;  4MHX A;  4NWJ A;  1E2S P;  1EQJ A;  1HDH A;  3NKR A;  4LR7 A;  2GA3 A;  4LQY A;  3WAV A; 
#chains in the Genus database with same CATH homology
 3WAW A;  5LRM A;  5L0E A;  4GTY A;  2W8S A;  4ZG9 A;  2W5R A;  3DYC A;  1E33 P;  2GSU A;  3B5Q A;  4KM4 A;  4QAX A;  5DLV A;  1EI6 A;  2GSN A;  4GTW A;  2ANH A;  2VQR A;  5LIA A;  5INH A;  2QZU A;  3BDH A;  4LR8 A;  5LRN A;  1AJC A;  3UN5 A;  3T02 A;  1AJA A;  1ZEF A;  3MK1 A;  2RH6 A;  4ZGA A;  1E3C P;  2XR9 A;  1B8J A;  3NVL A;  3M7V A;  5GRR A;  3M8Z A;  1ELZ A;  4LR2 A;  4LRC A;  3UN3 A;  4KJD A;  1ALK A;  2D1G A;  2W8D A;  2W5Q A;  2G9Y A;  3OT9 A;  4GTX A;  1URA A;  1ALJ A;  3NKO A;  1KH7 A;  5LQQ A;  1P49 A;  4TN0 A;  4UOO A;  1Y6V A;  3CMR A;  3BDF A;  4LRD A;  4LRB A;  1ANJ A;  1ANI A;  3BDG A;  3UO0 A;  3DPC A;  1HQA A;  3WBH A;  3SZY A;  3LXQ A;  3T01 A;  1AJB A;  3NKM A;  4UOP A;  4KJG A;  3ED4 A;  1ALI A;  4N7T A;  1KHN A;  3TWZ A;  5KXA A;  4UPH A;  1ZED A;  1AUK A;  2IFY A;  1EW8 A;  4ZG7 A;  5L0B A;  1ELY A;  4UOR A;  5AJ9 A;  3MK0 A;  1ED8 A;  4CYS A;  2IUC A;  4LRE A;  1KH5 A;  5L0K A;  4KAY A;  2ZKT A;  1KH9 A;  1SHN A;  3NKP A;  4LR9 A;  2W5V A;  4MIV A;  5IJQ A;  1ELX A;  4NWX A;  3KD8 A;  1EJJ A;  1KHL A;  5EGH A;  3TX0 A;  4FDJ A;  1ZEB A;  5HRT A;  2W5W A;  3M8W A;  1K7H A;  4MY4 A;  2X98 A;  4GTZ A;  4CXK A;  5EGE A;  5GOV A;  3A52 A;  1KHK A;  4UPL A;  3IGZ B;  1N2L A;  4UPI A;  4ZG6 A;  4YR1 A;  3Q3Q A;  1O98 A;  5TJ3 A;  3SZZ A;  2GSO A;  1KH4 A;  4LRA A;  1ALH A;  1SHQ A;  3T00 A;  3BDG B;  4UPK A;  5IJS A;  2XRG A;  3WAX A;  1ED9 A;  3WAY A;  4FDI A;  4CYR A;  4KAV A;  3M8Y A;  1FSU A;  3MK2 A;  3NKN A;  3IDD A;  1AJD A;  1O99 A;  1E1Z P;  1N2K A;  4CXS A;  2W5S A;  3E2D A;  3NKQ A;  1URB A;  2W5X A;  4B56 A;  1KHJ A;  1EW2 A;  3UN2 A;  2IUC B;  2W5T A;  5K4P A;  5DLW A;  2GLQ A;  1EW9 A;  3UNY A;  4CXU A;  5C66 A;  1HJK A;  1Y7A A;  3IGY B;  5DLT A;  3TG0 A;  4LRF A;  4MHX A;  4NWJ A;  1E2S P;  1EQJ A;  1HDH A;  3NKR A;  4LR7 A;  2GA3 A;  4LQY A;  3WAV A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...