3BDGB

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
446
structure length
433
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
total genus 159
structure length 433
sequence length 446
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgB00
3BDGA 4UOPA 3WAYA 4CYRA 2W5VA 5LRMA 4CXSA 4KAVA 1KH5A 4ZG9A 4LR7A 3E2DA 3Q3QA 1ALIA 1KHKA 4ZG7A 3OT9A 1AJAA 1ANIA 3NKMA 1Y6VA 2W8SA 4CYSA 4LRBA 2IFYA 3TX0A 5LIAA 3ED4A 1KH4A 3M7VA 1URBA 4UPHA 5L0BA 4FDIA 2GSUA 1HQAA 5LRNA 3UN5A 1EQJA 3M8WA 1KHJA 5K4PA 3NVLA 1KH9A 1KHNA 4KM4A 1KHLA 1EW2A 5C66A 4GTZA 2QZUA 3MK1A 3M8ZA 2ZKTA 4QAXA 4UPLA 5DLTA 1ALHA 3BDFA 3CMRA 1ZEFA 3T00A 1ALJA 2IUCA 3UO0A 4CXUA 2W8DA 5L0EA 3LXQA 1AJDA 3UN2A 5EGHA 2GSNA 1SHNA 1EJJA 1URAA 4GTYA 3DYCA 3T01A 3WAXA 1N2KA 3SZZA 3BDGB 1P49A 5GOVA 4LREA 2X98A 1HJKA 4ZG6A 5LQQA 1EI6A 1ALKA 1FSUA 1K7HA 4LR8A 1B8JA 3TWZA 1EW8A 5EGEA 4KJDA 5L0KA 3DPCA 4B56A 3NKQA 3NKPA 1E1ZP 2W5TA 2GA3A 2GSOA 3IGYB 1ANJA 1ED8A 4LRDA 4LRFA 1ELYA 1Y7AA 4UPKA 2W5QA 4UPIA 3UN3A 4MIVA 1EW9A 5DLWA 2D1GA 1ED9A 4UOOA 1E3CP 3B5QA 3NKOA 1ELXA 3MK2A 5DLVA 5HRTA 2W5SA 1E33P 2ANHA 5IJSA 3A52A 2XRGA 3MK0A 3SZYA 4UORA 3UNYA 4GTWA 3WBHA 1N2LA 4NWJA 4GTXA 5INHA 5AJ9A 1O98A 1ZEDA 3IGZB 4TN0A 3WAWA 1SHQA 4LRCA 3T02A 4MY4A 2IUCB 4LQYA 2W5RA 4MHXA 4YR1A 4FDJA 4LR2A 1KH7A 5TJ3A 3WAVA 5GRRA 2GLQA 1AJBA 2W5WA 3NKNA 4KAYA 3BDHA 3M8YA 2VQRA 4LRAA 1O99A 1AJCA 1E2SP 1ELZA 2W5XA 2RH6A 5KXAA 1AUKA 5IJQA 4CXKA 1HDHA 2G9YA 4N7TA 3TG0A 3KD8A 4LR9A 4KJGA 3IDDA 1ZEBA 4NWXA 4ZGAA 2XR9A 3NKRA
chains in the Genus database with same CATH superfamily
3BDGA 4UOPA 3WAYA 4CYRA 2W5VA 5LRMA 4CXSA 4KAVA 1KH5A 4ZG9A 4LR7A 3E2DA 3Q3QA 1ALIA 1KHKA 4ZG7A 3OT9A 1AJAA 1ANIA 3NKMA 1Y6VA 2W8SA 4CYSA 4LRBA 2IFYA 3TX0A 5LIAA 3ED4A 1KH4A 3M7VA 1URBA 4UPHA 5L0BA 4FDIA 2GSUA 1HQAA 5LRNA 3UN5A 1EQJA 3M8WA 1KHJA 5K4PA 3NVLA 1KH9A 1KHNA 4KM4A 1KHLA 1EW2A 5C66A 4GTZA 2QZUA 3MK1A 3M8ZA 2ZKTA 4QAXA 4UPLA 5DLTA 1ALHA 3BDFA 3CMRA 1ZEFA 3T00A 1ALJA 2IUCA 3UO0A 4CXUA 2W8DA 5L0EA 3LXQA 1AJDA 3UN2A 5EGHA 2GSNA 1SHNA 1EJJA 1URAA 4GTYA 3DYCA 3T01A 3WAXA 1N2KA 3SZZA 3BDGB 1P49A 5GOVA 4LREA 2X98A 1HJKA 4ZG6A 5LQQA 1EI6A 1ALKA 1FSUA 1K7HA 4LR8A 1B8JA 3TWZA 1EW8A 5EGEA 4KJDA 5L0KA 3DPCA 4B56A 3NKQA 3NKPA 1E1ZP 2W5TA 2GA3A 2GSOA 3IGYB 1ANJA 1ED8A 4LRDA 4LRFA 1ELYA 1Y7AA 4UPKA 2W5QA 4UPIA 3UN3A 4MIVA 1EW9A 5DLWA 2D1GA 1ED9A 4UOOA 1E3CP 3B5QA 3NKOA 1ELXA 3MK2A 5DLVA 5HRTA 2W5SA 1E33P 2ANHA 5IJSA 3A52A 2XRGA 3MK0A 3SZYA 4UORA 3UNYA 4GTWA 3WBHA 1N2LA 4NWJA 4GTXA 5INHA 5AJ9A 1O98A 1ZEDA 3IGZB 4TN0A 3WAWA 1SHQA 4LRCA 3T02A 4MY4A 2IUCB 4LQYA 2W5RA 4MHXA 4YR1A 4FDJA 4LR2A 1KH7A 5TJ3A 3WAVA 5GRRA 2GLQA 1AJBA 2W5WA 3NKNA 4KAYA 3BDHA 3M8YA 2VQRA 4LRAA 1O99A 1AJCA 1E2SP 1ELZA 2W5XA 2RH6A 5KXAA 1AUKA 5IJQA 4CXKA 1HDHA 2G9YA 4N7TA 3TG0A 3KD8A 4LR9A 4KJGA 3IDDA 1ZEBA 4NWXA 4ZGAA 2XR9A 3NKRA
chains in the Genus database with same CATH topology
3BDGA 4UOPA 3WAYA 4CYRA 2W5VA 5LRMA 4CXSA 4KAVA 1KH5A 4ZG9A 4LR7A 3E2DA 3Q3QA 1ALIA 1KHKA 4ZG7A 3OT9A 1AJAA 1ANIA 3NKMA 1Y6VA 2W8SA 4CYSA 4LRBA 2IFYA 3TX0A 5LIAA 3ED4A 1KH4A 3M7VA 1URBA 4UPHA 5L0BA 4FDIA 2GSUA 1HQAA 5LRNA 3UN5A 1EQJA 3M8WA 1KHJA 5K4PA 3NVLA 1KH9A 1KHNA 4KM4A 1KHLA 1EW2A 5C66A 4GTZA 2QZUA 3MK1A 3M8ZA 2ZKTA 4QAXA 4UPLA 5DLTA 1ALHA 3BDFA 3CMRA 1ZEFA 3T00A 1ALJA 2IUCA 3UO0A 4CXUA 2W8DA 5L0EA 3LXQA 1AJDA 3UN2A 5EGHA 2GSNA 1SHNA 1EJJA 1URAA 4GTYA 3DYCA 3T01A 3WAXA 1N2KA 3SZZA 3BDGB 1P49A 5GOVA 4LREA 2X98A 1HJKA 4ZG6A 5LQQA 1EI6A 1ALKA 1FSUA 1K7HA 4LR8A 1B8JA 3TWZA 1EW8A 5EGEA 4KJDA 5L0KA 3DPCA 4B56A 3NKQA 3NKPA 1E1ZP 2W5TA 2GA3A 2GSOA 3IGYB 1ANJA 1ED8A 4LRDA 4LRFA 1ELYA 1Y7AA 4UPKA 2W5QA 4UPIA 3UN3A 4MIVA 1EW9A 5DLWA 2D1GA 1ED9A 4UOOA 1E3CP 3B5QA 3NKOA 1ELXA 3MK2A 5DLVA 5HRTA 2W5SA 1E33P 2ANHA 5IJSA 3A52A 2XRGA 3MK0A 3SZYA 4UORA 3UNYA 4GTWA 3WBHA 1N2LA 4NWJA 4GTXA 5INHA 5AJ9A 1O98A 1ZEDA 3IGZB 4TN0A 3WAWA 1SHQA 4LRCA 3T02A 4MY4A 2IUCB 4LQYA 2W5RA 4MHXA 4YR1A 4FDJA 4LR2A 1KH7A 5TJ3A 3WAVA 5GRRA 2GLQA 1AJBA 2W5WA 3NKNA 4KAYA 3BDHA 3M8YA 2VQRA 4LRAA 1O99A 1AJCA 1E2SP 1ELZA 2W5XA 2RH6A 5KXAA 1AUKA 5IJQA 4CXKA 1HDHA 2G9YA 4N7TA 3TG0A 3KD8A 4LR9A 4KJGA 3IDDA 1ZEBA 4NWXA 4ZGAA 2XR9A 3NKRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDG A;  4UOP A;  3WAY A;  4CYR A;  2W5V A;  5LRM A;  4CXS A;  4KAV A;  1KH5 A;  4ZG9 A;  4LR7 A;  3E2D A;  3Q3Q A;  1ALI A;  1KHK A;  4ZG7 A;  3OT9 A;  1AJA A;  1ANI A;  3NKM A;  1Y6V A;  2W8S A;  4CYS A;  4LRB A;  2IFY A;  3TX0 A;  5LIA A;  3ED4 A;  1KH4 A;  3M7V A;  1URB A;  4UPH A;  5L0B A;  4FDI A;  2GSU A;  1HQA A;  5LRN A;  3UN5 A;  1EQJ A;  3M8W A;  1KHJ A;  5K4P A;  3NVL A;  1KH9 A;  1KHN A;  4KM4 A;  1KHL A;  1EW2 A;  5C66 A;  4GTZ A;  2QZU A;  3MK1 A;  3M8Z A;  2ZKT A;  4QAX A;  4UPL A;  5DLT A;  1ALH A;  3BDF A;  3CMR A;  1ZEF A;  3T00 A;  1ALJ A;  2IUC A;  3UO0 A;  4CXU A;  2W8D A;  5L0E A;  3LXQ A;  1AJD A;  3UN2 A;  5EGH A;  2GSN A;  1SHN A;  1EJJ A;  1URA A;  4GTY A;  3DYC A;  3T01 A;  3WAX A;  1N2K A;  3SZZ A;  3BDG B;  1P49 A;  5GOV A;  4LRE A;  2X98 A;  1HJK A;  4ZG6 A;  5LQQ A;  1EI6 A;  1ALK A;  1FSU A;  1K7H A;  4LR8 A;  1B8J A;  3TWZ A;  1EW8 A;  5EGE A;  4KJD A;  5L0K A;  3DPC A;  4B56 A;  3NKQ A;  3NKP A;  1E1Z P;  2W5T A;  2GA3 A;  2GSO A;  3IGY B;  1ANJ A;  1ED8 A;  4LRD A;  4LRF A;  1ELY A;  1Y7A A;  4UPK A;  2W5Q A;  4UPI A;  3UN3 A;  4MIV A;  1EW9 A;  5DLW A;  2D1G A;  1ED9 A;  4UOO A;  1E3C P;  3B5Q A;  3NKO A;  1ELX A;  3MK2 A;  5DLV A;  5HRT A;  2W5S A;  1E33 P;  2ANH A;  5IJS A;  3A52 A;  2XRG A;  3MK0 A;  3SZY A;  4UOR A;  3UNY A;  4GTW A;  3WBH A;  1N2L A;  4NWJ A;  4GTX A;  5INH A;  5AJ9 A;  1O98 A;  1ZED A;  3IGZ B;  4TN0 A;  3WAW A;  1SHQ A;  4LRC A;  3T02 A;  4MY4 A;  2IUC B;  4LQY A;  2W5R A;  4MHX A;  4YR1 A;  4FDJ A;  4LR2 A;  1KH7 A;  5TJ3 A;  3WAV A;  5GRR A;  2GLQ A;  1AJB A;  2W5W A;  3NKN A;  4KAY A;  3BDH A;  3M8Y A;  2VQR A;  4LRA A;  1O99 A;  1AJC A;  1E2S P;  1ELZ A;  2W5X A;  2RH6 A;  5KXA A;  1AUK A;  5IJQ A;  4CXK A;  1HDH A;  2G9Y A;  4N7T A;  3TG0 A;  3KD8 A;  4LR9 A;  4KJG A;  3IDD A;  1ZEB A;  4NWX A;  4ZGA A;  2XR9 A;  3NKR A; 
#chains in the Genus database with same CATH topology
 3BDG A;  4UOP A;  3WAY A;  4CYR A;  2W5V A;  5LRM A;  4CXS A;  4KAV A;  1KH5 A;  4ZG9 A;  4LR7 A;  3E2D A;  3Q3Q A;  1ALI A;  1KHK A;  4ZG7 A;  3OT9 A;  1AJA A;  1ANI A;  3NKM A;  1Y6V A;  2W8S A;  4CYS A;  4LRB A;  2IFY A;  3TX0 A;  5LIA A;  3ED4 A;  1KH4 A;  3M7V A;  1URB A;  4UPH A;  5L0B A;  4FDI A;  2GSU A;  1HQA A;  5LRN A;  3UN5 A;  1EQJ A;  3M8W A;  1KHJ A;  5K4P A;  3NVL A;  1KH9 A;  1KHN A;  4KM4 A;  1KHL A;  1EW2 A;  5C66 A;  4GTZ A;  2QZU A;  3MK1 A;  3M8Z A;  2ZKT A;  4QAX A;  4UPL A;  5DLT A;  1ALH A;  3BDF A;  3CMR A;  1ZEF A;  3T00 A;  1ALJ A;  2IUC A;  3UO0 A;  4CXU A;  2W8D A;  5L0E A;  3LXQ A;  1AJD A;  3UN2 A;  5EGH A;  2GSN A;  1SHN A;  1EJJ A;  1URA A;  4GTY A;  3DYC A;  3T01 A;  3WAX A;  1N2K A;  3SZZ A;  3BDG B;  1P49 A;  5GOV A;  4LRE A;  2X98 A;  1HJK A;  4ZG6 A;  5LQQ A;  1EI6 A;  1ALK A;  1FSU A;  1K7H A;  4LR8 A;  1B8J A;  3TWZ A;  1EW8 A;  5EGE A;  4KJD A;  5L0K A;  3DPC A;  4B56 A;  3NKQ A;  3NKP A;  1E1Z P;  2W5T A;  2GA3 A;  2GSO A;  3IGY B;  1ANJ A;  1ED8 A;  4LRD A;  4LRF A;  1ELY A;  1Y7A A;  4UPK A;  2W5Q A;  4UPI A;  3UN3 A;  4MIV A;  1EW9 A;  5DLW A;  2D1G A;  1ED9 A;  4UOO A;  1E3C P;  3B5Q A;  3NKO A;  1ELX A;  3MK2 A;  5DLV A;  5HRT A;  2W5S A;  1E33 P;  2ANH A;  5IJS A;  3A52 A;  2XRG A;  3MK0 A;  3SZY A;  4UOR A;  3UNY A;  4GTW A;  3WBH A;  1N2L A;  4NWJ A;  4GTX A;  5INH A;  5AJ9 A;  1O98 A;  1ZED A;  3IGZ B;  4TN0 A;  3WAW A;  1SHQ A;  4LRC A;  3T02 A;  4MY4 A;  2IUC B;  4LQY A;  2W5R A;  4MHX A;  4YR1 A;  4FDJ A;  4LR2 A;  1KH7 A;  5TJ3 A;  3WAV A;  5GRR A;  2GLQ A;  1AJB A;  2W5W A;  3NKN A;  4KAY A;  3BDH A;  3M8Y A;  2VQR A;  4LRA A;  1O99 A;  1AJC A;  1E2S P;  1ELZ A;  2W5X A;  2RH6 A;  5KXA A;  1AUK A;  5IJQ A;  4CXK A;  1HDH A;  2G9Y A;  4N7T A;  3TG0 A;  3KD8 A;  4LR9 A;  4KJG A;  3IDD A;  1ZEB A;  4NWX A;  4ZGA A;  2XR9 A;  3NKR A; 
#chains in the Genus database with same CATH homology
 3BDG A;  4UOP A;  3WAY A;  4CYR A;  2W5V A;  5LRM A;  4CXS A;  4KAV A;  1KH5 A;  4ZG9 A;  4LR7 A;  3E2D A;  3Q3Q A;  1ALI A;  1KHK A;  4ZG7 A;  3OT9 A;  1AJA A;  1ANI A;  3NKM A;  1Y6V A;  2W8S A;  4CYS A;  4LRB A;  2IFY A;  3TX0 A;  5LIA A;  3ED4 A;  1KH4 A;  3M7V A;  1URB A;  4UPH A;  5L0B A;  4FDI A;  2GSU A;  1HQA A;  5LRN A;  3UN5 A;  1EQJ A;  3M8W A;  1KHJ A;  5K4P A;  3NVL A;  1KH9 A;  1KHN A;  4KM4 A;  1KHL A;  1EW2 A;  5C66 A;  4GTZ A;  2QZU A;  3MK1 A;  3M8Z A;  2ZKT A;  4QAX A;  4UPL A;  5DLT A;  1ALH A;  3BDF A;  3CMR A;  1ZEF A;  3T00 A;  1ALJ A;  2IUC A;  3UO0 A;  4CXU A;  2W8D A;  5L0E A;  3LXQ A;  1AJD A;  3UN2 A;  5EGH A;  2GSN A;  1SHN A;  1EJJ A;  1URA A;  4GTY A;  3DYC A;  3T01 A;  3WAX A;  1N2K A;  3SZZ A;  3BDG B;  1P49 A;  5GOV A;  4LRE A;  2X98 A;  1HJK A;  4ZG6 A;  5LQQ A;  1EI6 A;  1ALK A;  1FSU A;  1K7H A;  4LR8 A;  1B8J A;  3TWZ A;  1EW8 A;  5EGE A;  4KJD A;  5L0K A;  3DPC A;  4B56 A;  3NKQ A;  3NKP A;  1E1Z P;  2W5T A;  2GA3 A;  2GSO A;  3IGY B;  1ANJ A;  1ED8 A;  4LRD A;  4LRF A;  1ELY A;  1Y7A A;  4UPK A;  2W5Q A;  4UPI A;  3UN3 A;  4MIV A;  1EW9 A;  5DLW A;  2D1G A;  1ED9 A;  4UOO A;  1E3C P;  3B5Q A;  3NKO A;  1ELX A;  3MK2 A;  5DLV A;  5HRT A;  2W5S A;  1E33 P;  2ANH A;  5IJS A;  3A52 A;  2XRG A;  3MK0 A;  3SZY A;  4UOR A;  3UNY A;  4GTW A;  3WBH A;  1N2L A;  4NWJ A;  4GTX A;  5INH A;  5AJ9 A;  1O98 A;  1ZED A;  3IGZ B;  4TN0 A;  3WAW A;  1SHQ A;  4LRC A;  3T02 A;  4MY4 A;  2IUC B;  4LQY A;  2W5R A;  4MHX A;  4YR1 A;  4FDJ A;  4LR2 A;  1KH7 A;  5TJ3 A;  3WAV A;  5GRR A;  2GLQ A;  1AJB A;  2W5W A;  3NKN A;  4KAY A;  3BDH A;  3M8Y A;  2VQR A;  4LRA A;  1O99 A;  1AJC A;  1E2S P;  1ELZ A;  2W5X A;  2RH6 A;  5KXA A;  1AUK A;  5IJQ A;  4CXK A;  1HDH A;  2G9Y A;  4N7T A;  3TG0 A;  3KD8 A;  4LR9 A;  4KJG A;  3IDD A;  1ZEB A;  4NWX A;  4ZGA A;  2XR9 A;  3NKR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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