3BDGB

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
446
structure length
433
Chain Sequence
b'MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 433
sequence length 446
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgB00
1URAA 4GTXA 4CYSA 2GSOA 4LR7A 3LXQA 1Y7AA 5EGEA 2W5TA 3BDHA 2VQRA 3MK0A 1KHJA 4KAYA 4LRAA 2XR9A 3WAYA 5LRMA 5LIAA 2G9YA 1SHNA 3B5QA 4LRBA 4KJDA 5TJ3A 3UN3A 1ANIA 4UOOA 1EQJA 2W8DA 4TN0A 4UPKA 3Q3QA 1O98A 4UORA 3NKOA 1HJKA 2QZUA 4GTWA 5C66A 3ED4A 4ZG7A 2IUCA 4MHXA 1KH9A 2W8SA 2IFYA 1EI6A 1ALKA 2W5VA 3OT9A 1EW8A 3TX0A 3WBHA 1ZEDA 3CMRA 1O99A 3T00A 1E1ZP 3A52A 3WAXA 4FDJA 4LRDA 4N7TA 2W5QA 4NWJA 4MIVA 3UO0A 3NKPA 2GSNA 3BDGA 4CYRA 3UN5A 1E3CP 4MY4A 1ELZA 4CXSA 1B8JA 1AJCA 3WAVA 4FDIA 4ZG6A 5HRTA 1EW2A 5LQQA 4LR2A 3IDDA 1AUKA 5L0BA 1ELXA 3M8ZA 3NKNA 4NWXA 5L0KA 4CXKA 4UPIA 3TWZA 1SHQA 5INHA 1KHLA 1AJAA 4UOPA 3MK2A 4GTZA 4UPLA 1KH7A 5L0EA 5IJSA 2W5SA 1P49A 2RH6A 3DYCA 3M7VA 1KHKA 1ZEBA 4LRFA 5IJQA 1HDHA 3TG0A 4KAVA 1URBA 5K4PA 5DLVA 3NKQA 3SZYA 3SZZA 5GRRA 1N2KA 2W5RA 1AJBA 3T01A 3NKRA 2IUCB 3UN2A 4ZG9A 5LRNA 3NVLA 5DLWA 2D1GA 4LR9A 3IGYB 4KM4A 1ELYA 4QAXA 5KXAA 2GA3A 3DPCA 1HQAA 1N2LA 4LREA 1EJJA 1ANJA 1E2SP 3UNYA 2GLQA 2ANHA 2W5XA 4UPHA 4ZGAA 1KHNA 1KH5A 4KJGA 3WAWA 1E33P 3BDGB 4LR8A 1ED9A 4LRCA 3M8WA 5GOVA 1EW9A 1FSUA 3E2DA 5AJ9A 1AJDA 3IGZB 3NKMA 1ALJA 3M8YA 2W5WA 2XRGA 1ALIA 4GTYA 3T02A 4CXUA 2ZKTA 4YR1A 1KH4A 1Y6VA 4LQYA 1K7HA 3BDFA 2GSUA 5EGHA 1ALHA 3KD8A 2X98A 1ZEFA 4B56A 3MK1A 5DLTA 1ED8A
chains in the Genus database with same CATH superfamily
1URAA 4GTXA 4CYSA 2GSOA 4LR7A 3LXQA 1Y7AA 5EGEA 2W5TA 3BDHA 2VQRA 3MK0A 1KHJA 4KAYA 4LRAA 2XR9A 3WAYA 5LRMA 5LIAA 2G9YA 1SHNA 3B5QA 4LRBA 4KJDA 5TJ3A 3UN3A 1ANIA 4UOOA 1EQJA 2W8DA 4TN0A 4UPKA 3Q3QA 1O98A 4UORA 3NKOA 1HJKA 2QZUA 4GTWA 5C66A 3ED4A 4ZG7A 2IUCA 4MHXA 1KH9A 2W8SA 2IFYA 1EI6A 1ALKA 2W5VA 3OT9A 1EW8A 3TX0A 3WBHA 1ZEDA 3CMRA 1O99A 3T00A 1E1ZP 3A52A 3WAXA 4FDJA 4LRDA 4N7TA 2W5QA 4NWJA 4MIVA 3UO0A 3NKPA 2GSNA 3BDGA 4CYRA 3UN5A 1E3CP 4MY4A 1ELZA 4CXSA 1B8JA 1AJCA 3WAVA 4FDIA 4ZG6A 5HRTA 1EW2A 5LQQA 4LR2A 3IDDA 1AUKA 5L0BA 1ELXA 3M8ZA 3NKNA 4NWXA 5L0KA 4CXKA 4UPIA 3TWZA 1SHQA 5INHA 1KHLA 1AJAA 4UOPA 3MK2A 4GTZA 4UPLA 1KH7A 5L0EA 5IJSA 2W5SA 1P49A 2RH6A 3DYCA 3M7VA 1KHKA 1ZEBA 4LRFA 5IJQA 1HDHA 3TG0A 4KAVA 1URBA 5K4PA 5DLVA 3NKQA 3SZYA 3SZZA 5GRRA 1N2KA 2W5RA 1AJBA 3T01A 3NKRA 2IUCB 3UN2A 4ZG9A 5LRNA 3NVLA 5DLWA 2D1GA 4LR9A 3IGYB 4KM4A 1ELYA 4QAXA 5KXAA 2GA3A 3DPCA 1HQAA 1N2LA 4LREA 1EJJA 1ANJA 1E2SP 3UNYA 2GLQA 2ANHA 2W5XA 4UPHA 4ZGAA 1KHNA 1KH5A 4KJGA 3WAWA 1E33P 3BDGB 4LR8A 1ED9A 4LRCA 3M8WA 5GOVA 1EW9A 1FSUA 3E2DA 5AJ9A 1AJDA 3IGZB 3NKMA 1ALJA 3M8YA 2W5WA 2XRGA 1ALIA 4GTYA 3T02A 4CXUA 2ZKTA 4YR1A 1KH4A 1Y6VA 4LQYA 1K7HA 3BDFA 2GSUA 5EGHA 1ALHA 3KD8A 2X98A 1ZEFA 4B56A 3MK1A 5DLTA 1ED8A
chains in the Genus database with same CATH topology
1URAA 4GTXA 4CYSA 2GSOA 4LR7A 3LXQA 1Y7AA 5EGEA 2W5TA 3BDHA 2VQRA 3MK0A 1KHJA 4KAYA 4LRAA 2XR9A 3WAYA 5LRMA 5LIAA 2G9YA 1SHNA 3B5QA 4LRBA 4KJDA 5TJ3A 3UN3A 1ANIA 4UOOA 1EQJA 2W8DA 4TN0A 4UPKA 3Q3QA 1O98A 4UORA 3NKOA 1HJKA 2QZUA 4GTWA 5C66A 3ED4A 4ZG7A 2IUCA 4MHXA 1KH9A 2W8SA 2IFYA 1EI6A 1ALKA 2W5VA 3OT9A 1EW8A 3TX0A 3WBHA 1ZEDA 3CMRA 1O99A 3T00A 1E1ZP 3A52A 3WAXA 4FDJA 4LRDA 4N7TA 2W5QA 4NWJA 4MIVA 3UO0A 3NKPA 2GSNA 3BDGA 4CYRA 3UN5A 1E3CP 4MY4A 1ELZA 4CXSA 1B8JA 1AJCA 3WAVA 4FDIA 4ZG6A 5HRTA 1EW2A 5LQQA 4LR2A 3IDDA 1AUKA 5L0BA 1ELXA 3M8ZA 3NKNA 4NWXA 5L0KA 4CXKA 4UPIA 3TWZA 1SHQA 5INHA 1KHLA 1AJAA 4UOPA 3MK2A 4GTZA 4UPLA 1KH7A 5L0EA 5IJSA 2W5SA 1P49A 2RH6A 3DYCA 3M7VA 1KHKA 1ZEBA 4LRFA 5IJQA 1HDHA 3TG0A 4KAVA 1URBA 5K4PA 5DLVA 3NKQA 3SZYA 3SZZA 5GRRA 1N2KA 2W5RA 1AJBA 3T01A 3NKRA 2IUCB 3UN2A 4ZG9A 5LRNA 3NVLA 5DLWA 2D1GA 4LR9A 3IGYB 4KM4A 1ELYA 4QAXA 5KXAA 2GA3A 3DPCA 1HQAA 1N2LA 4LREA 1EJJA 1ANJA 1E2SP 3UNYA 2GLQA 2ANHA 2W5XA 4UPHA 4ZGAA 1KHNA 1KH5A 4KJGA 3WAWA 1E33P 3BDGB 4LR8A 1ED9A 4LRCA 3M8WA 5GOVA 1EW9A 1FSUA 3E2DA 5AJ9A 1AJDA 3IGZB 3NKMA 1ALJA 3M8YA 2W5WA 2XRGA 1ALIA 4GTYA 3T02A 4CXUA 2ZKTA 4YR1A 1KH4A 1Y6VA 4LQYA 1K7HA 3BDFA 2GSUA 5EGHA 1ALHA 3KD8A 2X98A 1ZEFA 4B56A 3MK1A 5DLTA 1ED8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1URA A;  4GTX A;  4CYS A;  2GSO A;  4LR7 A;  3LXQ A;  1Y7A A;  5EGE A;  2W5T A;  3BDH A;  2VQR A;  3MK0 A;  1KHJ A;  4KAY A;  4LRA A;  2XR9 A;  3WAY A;  5LRM A;  5LIA A;  2G9Y A;  1SHN A;  3B5Q A;  4LRB A;  4KJD A;  5TJ3 A;  3UN3 A;  1ANI A;  4UOO A;  1EQJ A;  2W8D A;  4TN0 A;  4UPK A;  3Q3Q A;  1O98 A;  4UOR A;  3NKO A;  1HJK A;  2QZU A;  4GTW A;  5C66 A;  3ED4 A;  4ZG7 A;  2IUC A;  4MHX A;  1KH9 A;  2W8S A;  2IFY A;  1EI6 A;  1ALK A;  2W5V A;  3OT9 A;  1EW8 A;  3TX0 A;  3WBH A;  1ZED A;  3CMR A;  1O99 A;  3T00 A;  1E1Z P;  3A52 A;  3WAX A;  4FDJ A;  4LRD A;  4N7T A;  2W5Q A;  4NWJ A;  4MIV A;  3UO0 A;  3NKP A;  2GSN A;  3BDG A;  4CYR A;  3UN5 A;  1E3C P;  4MY4 A;  1ELZ A;  4CXS A;  1B8J A;  1AJC A;  3WAV A;  4FDI A;  4ZG6 A;  5HRT A;  1EW2 A;  5LQQ A;  4LR2 A;  3IDD A;  1AUK A;  5L0B A;  1ELX A;  3M8Z A;  3NKN A;  4NWX A;  5L0K A;  4CXK A;  4UPI A;  3TWZ A;  1SHQ A;  5INH A;  1KHL A;  1AJA A;  4UOP A;  3MK2 A;  4GTZ A;  4UPL A;  1KH7 A;  5L0E A;  5IJS A;  2W5S A;  1P49 A;  2RH6 A;  3DYC A;  3M7V A;  1KHK A;  1ZEB A;  4LRF A;  5IJQ A;  1HDH A;  3TG0 A;  4KAV A;  1URB A;  5K4P A;  5DLV A;  3NKQ A;  3SZY A;  3SZZ A;  5GRR A;  1N2K A;  2W5R A;  1AJB A;  3T01 A;  3NKR A;  2IUC B;  3UN2 A;  4ZG9 A;  5LRN A;  3NVL A;  5DLW A;  2D1G A;  4LR9 A;  3IGY B;  4KM4 A;  1ELY A;  4QAX A;  5KXA A;  2GA3 A;  3DPC A;  1HQA A;  1N2L A;  4LRE A;  1EJJ A;  1ANJ A;  1E2S P;  3UNY A;  2GLQ A;  2ANH A;  2W5X A;  4UPH A;  4ZGA A;  1KHN A;  1KH5 A;  4KJG A;  3WAW A;  1E33 P;  3BDG B;  4LR8 A;  1ED9 A;  4LRC A;  3M8W A;  5GOV A;  1EW9 A;  1FSU A;  3E2D A;  5AJ9 A;  1AJD A;  3IGZ B;  3NKM A;  1ALJ A;  3M8Y A;  2W5W A;  2XRG A;  1ALI A;  4GTY A;  3T02 A;  4CXU A;  2ZKT A;  4YR1 A;  1KH4 A;  1Y6V A;  4LQY A;  1K7H A;  3BDF A;  2GSU A;  5EGH A;  1ALH A;  3KD8 A;  2X98 A;  1ZEF A;  4B56 A;  3MK1 A;  5DLT A;  1ED8 A; 
#chains in the Genus database with same CATH topology
 1URA A;  4GTX A;  4CYS A;  2GSO A;  4LR7 A;  3LXQ A;  1Y7A A;  5EGE A;  2W5T A;  3BDH A;  2VQR A;  3MK0 A;  1KHJ A;  4KAY A;  4LRA A;  2XR9 A;  3WAY A;  5LRM A;  5LIA A;  2G9Y A;  1SHN A;  3B5Q A;  4LRB A;  4KJD A;  5TJ3 A;  3UN3 A;  1ANI A;  4UOO A;  1EQJ A;  2W8D A;  4TN0 A;  4UPK A;  3Q3Q A;  1O98 A;  4UOR A;  3NKO A;  1HJK A;  2QZU A;  4GTW A;  5C66 A;  3ED4 A;  4ZG7 A;  2IUC A;  4MHX A;  1KH9 A;  2W8S A;  2IFY A;  1EI6 A;  1ALK A;  2W5V A;  3OT9 A;  1EW8 A;  3TX0 A;  3WBH A;  1ZED A;  3CMR A;  1O99 A;  3T00 A;  1E1Z P;  3A52 A;  3WAX A;  4FDJ A;  4LRD A;  4N7T A;  2W5Q A;  4NWJ A;  4MIV A;  3UO0 A;  3NKP A;  2GSN A;  3BDG A;  4CYR A;  3UN5 A;  1E3C P;  4MY4 A;  1ELZ A;  4CXS A;  1B8J A;  1AJC A;  3WAV A;  4FDI A;  4ZG6 A;  5HRT A;  1EW2 A;  5LQQ A;  4LR2 A;  3IDD A;  1AUK A;  5L0B A;  1ELX A;  3M8Z A;  3NKN A;  4NWX A;  5L0K A;  4CXK A;  4UPI A;  3TWZ A;  1SHQ A;  5INH A;  1KHL A;  1AJA A;  4UOP A;  3MK2 A;  4GTZ A;  4UPL A;  1KH7 A;  5L0E A;  5IJS A;  2W5S A;  1P49 A;  2RH6 A;  3DYC A;  3M7V A;  1KHK A;  1ZEB A;  4LRF A;  5IJQ A;  1HDH A;  3TG0 A;  4KAV A;  1URB A;  5K4P A;  5DLV A;  3NKQ A;  3SZY A;  3SZZ A;  5GRR A;  1N2K A;  2W5R A;  1AJB A;  3T01 A;  3NKR A;  2IUC B;  3UN2 A;  4ZG9 A;  5LRN A;  3NVL A;  5DLW A;  2D1G A;  4LR9 A;  3IGY B;  4KM4 A;  1ELY A;  4QAX A;  5KXA A;  2GA3 A;  3DPC A;  1HQA A;  1N2L A;  4LRE A;  1EJJ A;  1ANJ A;  1E2S P;  3UNY A;  2GLQ A;  2ANH A;  2W5X A;  4UPH A;  4ZGA A;  1KHN A;  1KH5 A;  4KJG A;  3WAW A;  1E33 P;  3BDG B;  4LR8 A;  1ED9 A;  4LRC A;  3M8W A;  5GOV A;  1EW9 A;  1FSU A;  3E2D A;  5AJ9 A;  1AJD A;  3IGZ B;  3NKM A;  1ALJ A;  3M8Y A;  2W5W A;  2XRG A;  1ALI A;  4GTY A;  3T02 A;  4CXU A;  2ZKT A;  4YR1 A;  1KH4 A;  1Y6V A;  4LQY A;  1K7H A;  3BDF A;  2GSU A;  5EGH A;  1ALH A;  3KD8 A;  2X98 A;  1ZEF A;  4B56 A;  3MK1 A;  5DLT A;  1ED8 A; 
#chains in the Genus database with same CATH homology
 1URA A;  4GTX A;  4CYS A;  2GSO A;  4LR7 A;  3LXQ A;  1Y7A A;  5EGE A;  2W5T A;  3BDH A;  2VQR A;  3MK0 A;  1KHJ A;  4KAY A;  4LRA A;  2XR9 A;  3WAY A;  5LRM A;  5LIA A;  2G9Y A;  1SHN A;  3B5Q A;  4LRB A;  4KJD A;  5TJ3 A;  3UN3 A;  1ANI A;  4UOO A;  1EQJ A;  2W8D A;  4TN0 A;  4UPK A;  3Q3Q A;  1O98 A;  4UOR A;  3NKO A;  1HJK A;  2QZU A;  4GTW A;  5C66 A;  3ED4 A;  4ZG7 A;  2IUC A;  4MHX A;  1KH9 A;  2W8S A;  2IFY A;  1EI6 A;  1ALK A;  2W5V A;  3OT9 A;  1EW8 A;  3TX0 A;  3WBH A;  1ZED A;  3CMR A;  1O99 A;  3T00 A;  1E1Z P;  3A52 A;  3WAX A;  4FDJ A;  4LRD A;  4N7T A;  2W5Q A;  4NWJ A;  4MIV A;  3UO0 A;  3NKP A;  2GSN A;  3BDG A;  4CYR A;  3UN5 A;  1E3C P;  4MY4 A;  1ELZ A;  4CXS A;  1B8J A;  1AJC A;  3WAV A;  4FDI A;  4ZG6 A;  5HRT A;  1EW2 A;  5LQQ A;  4LR2 A;  3IDD A;  1AUK A;  5L0B A;  1ELX A;  3M8Z A;  3NKN A;  4NWX A;  5L0K A;  4CXK A;  4UPI A;  3TWZ A;  1SHQ A;  5INH A;  1KHL A;  1AJA A;  4UOP A;  3MK2 A;  4GTZ A;  4UPL A;  1KH7 A;  5L0E A;  5IJS A;  2W5S A;  1P49 A;  2RH6 A;  3DYC A;  3M7V A;  1KHK A;  1ZEB A;  4LRF A;  5IJQ A;  1HDH A;  3TG0 A;  4KAV A;  1URB A;  5K4P A;  5DLV A;  3NKQ A;  3SZY A;  3SZZ A;  5GRR A;  1N2K A;  2W5R A;  1AJB A;  3T01 A;  3NKR A;  2IUC B;  3UN2 A;  4ZG9 A;  5LRN A;  3NVL A;  5DLW A;  2D1G A;  4LR9 A;  3IGY B;  4KM4 A;  1ELY A;  4QAX A;  5KXA A;  2GA3 A;  3DPC A;  1HQA A;  1N2L A;  4LRE A;  1EJJ A;  1ANJ A;  1E2S P;  3UNY A;  2GLQ A;  2ANH A;  2W5X A;  4UPH A;  4ZGA A;  1KHN A;  1KH5 A;  4KJG A;  3WAW A;  1E33 P;  3BDG B;  4LR8 A;  1ED9 A;  4LRC A;  3M8W A;  5GOV A;  1EW9 A;  1FSU A;  3E2D A;  5AJ9 A;  1AJD A;  3IGZ B;  3NKM A;  1ALJ A;  3M8Y A;  2W5W A;  2XRG A;  1ALI A;  4GTY A;  3T02 A;  4CXU A;  2ZKT A;  4YR1 A;  1KH4 A;  1Y6V A;  4LQY A;  1K7H A;  3BDF A;  2GSU A;  5EGH A;  1ALH A;  3KD8 A;  2X98 A;  1ZEF A;  4B56 A;  3MK1 A;  5DLT A;  1ED8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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