5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Hydrolase
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
4MHXA 3BDGB 4QAXA 1SHNA 2GA3A 5L0EA 3M8ZA 1KH9A 2W5WA 1AJCA 4GTZA 5C66A 2XR9A 4TN0A 1URAA 4CYRA 1HDHA 2ZKTA 3WAYA 4ZG9A 1KH5A 1KHNA 2X98A 3ED4A 3IGZB 1ANJA 4KJDA 4UOOA 1N2LA 3DPCA 1ZEDA 3T02A 4UOPA 2IFYA 1E3CP 4ZG7A 2QZUA 1ANIA 3IDDA 1O99A 1AUKA 1K7HA 1ALKA 4GTYA 3IGYB 2ANHA 1O98A 1ALIA 4CXKA 1ZEBA 3OT9A 4LRDA 3BDHA 4UPIA 3M8WA 1ELXA 1N2KA 1KH4A 5DLTA 2G9YA 1EW8A 1HJKA 4ZG6A 3LXQA 3A52A 5GOVA 1EW9A 3T00A 1B8JA 4CXSA 1ZEFA 5TJ3A 1E2SP 2W5TA 3MK0A 5LRMA 4LQYA 1AJBA 3WBHA 1SHQA 2RH6A 1ELZA 1EI6A 5LIAA 1ALJA 3Q3QA 5EGHA 5IJSA 3MK1A 4LR7A 3KD8A 4UORA 2GSNA 1P49A 2VQRA 3WAXA 5INHA 4GTWA 3TG0A 5LRNA 4MIVA 3M7VA 4UPLA 2GLQA 2W8SA 5KXAA 5HRTA 4LR2A 3UN3A 4CXUA 5DLVA 5L0KA 1HQAA 5K4PA 5GRRA 1AJDA 3NKPA 2W8DA 3NKRA 2W5RA 4LRBA 4KM4A 1ED8A 4B56A 2W5QA 1EW2A 1KHLA 1Y6VA 4CYSA 3NKNA 3WAWA 4FDJA 3E2DA 3UN2A 2D1GA 4MY4A 5LQQA 1EJJA 4GTXA 3MK2A 4LR9A 3BDFA 4LR8A 4NWXA 1ED9A 1ELYA 3TX0A 1EQJA 4KAYA 3NKQA 4ZGAA 1ALHA 1Y7AA 2GSUA 3CMRA 4UPKA 1FSUA 4NWJA 3UO0A 3NVLA 2W5SA 3UN5A 2IUCA 4FDIA 5IJQA 4YR1A 2W5VA 1AJAA 4KAVA 5DLWA 4UPHA 1URBA 3UNYA 4LRAA 3SZYA 2IUCB 3SZZA 3M8YA 4LRFA 3TWZA 1KH7A 4KJGA 3DYCA 5EGEA 2GSOA 4N7TA 4LREA 1KHJA 3NKMA 1E1ZP 3T01A 3NKOA 3WAVA 3BDGA 4LRCA 1E33P 5L0BA 1KHKA 3B5QA 2XRGA 5AJ9A 2W5XA
chains in the Genus database with same CATH superfamily
4MHXA 3BDGB 4QAXA 1SHNA 2GA3A 5L0EA 3M8ZA 1KH9A 2W5WA 1AJCA 4GTZA 5C66A 2XR9A 4TN0A 1URAA 4CYRA 1HDHA 2ZKTA 3WAYA 4ZG9A 1KH5A 1KHNA 2X98A 3ED4A 3IGZB 1ANJA 4KJDA 4UOOA 1N2LA 3DPCA 1ZEDA 3T02A 4UOPA 2IFYA 1E3CP 4ZG7A 2QZUA 1ANIA 3IDDA 1O99A 1AUKA 1K7HA 1ALKA 4GTYA 3IGYB 2ANHA 1O98A 1ALIA 4CXKA 1ZEBA 3OT9A 4LRDA 3BDHA 4UPIA 3M8WA 1ELXA 1N2KA 1KH4A 5DLTA 2G9YA 1EW8A 1HJKA 4ZG6A 3LXQA 3A52A 5GOVA 1EW9A 3T00A 1B8JA 4CXSA 1ZEFA 5TJ3A 1E2SP 2W5TA 3MK0A 5LRMA 4LQYA 1AJBA 3WBHA 1SHQA 2RH6A 1ELZA 1EI6A 5LIAA 1ALJA 3Q3QA 5EGHA 5IJSA 3MK1A 4LR7A 3KD8A 4UORA 2GSNA 1P49A 2VQRA 3WAXA 5INHA 4GTWA 3TG0A 5LRNA 4MIVA 3M7VA 4UPLA 2GLQA 2W8SA 5KXAA 5HRTA 4LR2A 3UN3A 4CXUA 5DLVA 5L0KA 1HQAA 5K4PA 5GRRA 1AJDA 3NKPA 2W8DA 3NKRA 2W5RA 4LRBA 4KM4A 1ED8A 4B56A 2W5QA 1EW2A 1KHLA 1Y6VA 4CYSA 3NKNA 3WAWA 4FDJA 3E2DA 3UN2A 2D1GA 4MY4A 5LQQA 1EJJA 4GTXA 3MK2A 4LR9A 3BDFA 4LR8A 4NWXA 1ED9A 1ELYA 3TX0A 1EQJA 4KAYA 3NKQA 4ZGAA 1ALHA 1Y7AA 2GSUA 3CMRA 4UPKA 1FSUA 4NWJA 3UO0A 3NVLA 2W5SA 3UN5A 2IUCA 4FDIA 5IJQA 4YR1A 2W5VA 1AJAA 4KAVA 5DLWA 4UPHA 1URBA 3UNYA 4LRAA 3SZYA 2IUCB 3SZZA 3M8YA 4LRFA 3TWZA 1KH7A 4KJGA 3DYCA 5EGEA 2GSOA 4N7TA 4LREA 1KHJA 3NKMA 1E1ZP 3T01A 3NKOA 3WAVA 3BDGA 4LRCA 1E33P 5L0BA 1KHKA 3B5QA 2XRGA 5AJ9A 2W5XA
chains in the Genus database with same CATH topology
4MHXA 3BDGB 4QAXA 1SHNA 2GA3A 5L0EA 3M8ZA 1KH9A 2W5WA 1AJCA 4GTZA 5C66A 2XR9A 4TN0A 1URAA 4CYRA 1HDHA 2ZKTA 3WAYA 4ZG9A 1KH5A 1KHNA 2X98A 3ED4A 3IGZB 1ANJA 4KJDA 4UOOA 1N2LA 3DPCA 1ZEDA 3T02A 4UOPA 2IFYA 1E3CP 4ZG7A 2QZUA 1ANIA 3IDDA 1O99A 1AUKA 1K7HA 1ALKA 4GTYA 3IGYB 2ANHA 1O98A 1ALIA 4CXKA 1ZEBA 3OT9A 4LRDA 3BDHA 4UPIA 3M8WA 1ELXA 1N2KA 1KH4A 5DLTA 2G9YA 1EW8A 1HJKA 4ZG6A 3LXQA 3A52A 5GOVA 1EW9A 3T00A 1B8JA 4CXSA 1ZEFA 5TJ3A 1E2SP 2W5TA 3MK0A 5LRMA 4LQYA 1AJBA 3WBHA 1SHQA 2RH6A 1ELZA 1EI6A 5LIAA 1ALJA 3Q3QA 5EGHA 5IJSA 3MK1A 4LR7A 3KD8A 4UORA 2GSNA 1P49A 2VQRA 3WAXA 5INHA 4GTWA 3TG0A 5LRNA 4MIVA 3M7VA 4UPLA 2GLQA 2W8SA 5KXAA 5HRTA 4LR2A 3UN3A 4CXUA 5DLVA 5L0KA 1HQAA 5K4PA 5GRRA 1AJDA 3NKPA 2W8DA 3NKRA 2W5RA 4LRBA 4KM4A 1ED8A 4B56A 2W5QA 1EW2A 1KHLA 1Y6VA 4CYSA 3NKNA 3WAWA 4FDJA 3E2DA 3UN2A 2D1GA 4MY4A 5LQQA 1EJJA 4GTXA 3MK2A 4LR9A 3BDFA 4LR8A 4NWXA 1ED9A 1ELYA 3TX0A 1EQJA 4KAYA 3NKQA 4ZGAA 1ALHA 1Y7AA 2GSUA 3CMRA 4UPKA 1FSUA 4NWJA 3UO0A 3NVLA 2W5SA 3UN5A 2IUCA 4FDIA 5IJQA 4YR1A 2W5VA 1AJAA 4KAVA 5DLWA 4UPHA 1URBA 3UNYA 4LRAA 3SZYA 2IUCB 3SZZA 3M8YA 4LRFA 3TWZA 1KH7A 4KJGA 3DYCA 5EGEA 2GSOA 4N7TA 4LREA 1KHJA 3NKMA 1E1ZP 3T01A 3NKOA 3WAVA 3BDGA 4LRCA 1E33P 5L0BA 1KHKA 3B5QA 2XRGA 5AJ9A 2W5XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MHX A;  3BDG B;  4QAX A;  1SHN A;  2GA3 A;  5L0E A;  3M8Z A;  1KH9 A;  2W5W A;  1AJC A;  4GTZ A;  5C66 A;  2XR9 A;  4TN0 A;  1URA A;  4CYR A;  1HDH A;  2ZKT A;  3WAY A;  4ZG9 A;  1KH5 A;  1KHN A;  2X98 A;  3ED4 A;  3IGZ B;  1ANJ A;  4KJD A;  4UOO A;  1N2L A;  3DPC A;  1ZED A;  3T02 A;  4UOP A;  2IFY A;  1E3C P;  4ZG7 A;  2QZU A;  1ANI A;  3IDD A;  1O99 A;  1AUK A;  1K7H A;  1ALK A;  4GTY A;  3IGY B;  2ANH A;  1O98 A;  1ALI A;  4CXK A;  1ZEB A;  3OT9 A;  4LRD A;  3BDH A;  4UPI A;  3M8W A;  1ELX A;  1N2K A;  1KH4 A;  5DLT A;  2G9Y A;  1EW8 A;  1HJK A;  4ZG6 A;  3LXQ A;  3A52 A;  5GOV A;  1EW9 A;  3T00 A;  1B8J A;  4CXS A;  1ZEF A;  5TJ3 A;  1E2S P;  2W5T A;  3MK0 A;  5LRM A;  4LQY A;  1AJB A;  3WBH A;  1SHQ A;  2RH6 A;  1ELZ A;  1EI6 A;  5LIA A;  1ALJ A;  3Q3Q A;  5EGH A;  5IJS A;  3MK1 A;  4LR7 A;  3KD8 A;  4UOR A;  2GSN A;  1P49 A;  2VQR A;  3WAX A;  5INH A;  4GTW A;  3TG0 A;  5LRN A;  4MIV A;  3M7V A;  4UPL A;  2GLQ A;  2W8S A;  5KXA A;  5HRT A;  4LR2 A;  3UN3 A;  4CXU A;  5DLV A;  5L0K A;  1HQA A;  5K4P A;  5GRR A;  1AJD A;  3NKP A;  2W8D A;  3NKR A;  2W5R A;  4LRB A;  4KM4 A;  1ED8 A;  4B56 A;  2W5Q A;  1EW2 A;  1KHL A;  1Y6V A;  4CYS A;  3NKN A;  3WAW A;  4FDJ A;  3E2D A;  3UN2 A;  2D1G A;  4MY4 A;  5LQQ A;  1EJJ A;  4GTX A;  3MK2 A;  4LR9 A;  3BDF A;  4LR8 A;  4NWX A;  1ED9 A;  1ELY A;  3TX0 A;  1EQJ A;  4KAY A;  3NKQ A;  4ZGA A;  1ALH A;  1Y7A A;  2GSU A;  3CMR A;  4UPK A;  1FSU A;  4NWJ A;  3UO0 A;  3NVL A;  2W5S A;  3UN5 A;  2IUC A;  4FDI A;  5IJQ A;  4YR1 A;  2W5V A;  1AJA A;  4KAV A;  5DLW A;  4UPH A;  1URB A;  3UNY A;  4LRA A;  3SZY A;  2IUC B;  3SZZ A;  3M8Y A;  4LRF A;  3TWZ A;  1KH7 A;  4KJG A;  3DYC A;  5EGE A;  2GSO A;  4N7T A;  4LRE A;  1KHJ A;  3NKM A;  1E1Z P;  3T01 A;  3NKO A;  3WAV A;  3BDG A;  4LRC A;  1E33 P;  5L0B A;  1KHK A;  3B5Q A;  2XRG A;  5AJ9 A;  2W5X A; 
#chains in the Genus database with same CATH topology
 4MHX A;  3BDG B;  4QAX A;  1SHN A;  2GA3 A;  5L0E A;  3M8Z A;  1KH9 A;  2W5W A;  1AJC A;  4GTZ A;  5C66 A;  2XR9 A;  4TN0 A;  1URA A;  4CYR A;  1HDH A;  2ZKT A;  3WAY A;  4ZG9 A;  1KH5 A;  1KHN A;  2X98 A;  3ED4 A;  3IGZ B;  1ANJ A;  4KJD A;  4UOO A;  1N2L A;  3DPC A;  1ZED A;  3T02 A;  4UOP A;  2IFY A;  1E3C P;  4ZG7 A;  2QZU A;  1ANI A;  3IDD A;  1O99 A;  1AUK A;  1K7H A;  1ALK A;  4GTY A;  3IGY B;  2ANH A;  1O98 A;  1ALI A;  4CXK A;  1ZEB A;  3OT9 A;  4LRD A;  3BDH A;  4UPI A;  3M8W A;  1ELX A;  1N2K A;  1KH4 A;  5DLT A;  2G9Y A;  1EW8 A;  1HJK A;  4ZG6 A;  3LXQ A;  3A52 A;  5GOV A;  1EW9 A;  3T00 A;  1B8J A;  4CXS A;  1ZEF A;  5TJ3 A;  1E2S P;  2W5T A;  3MK0 A;  5LRM A;  4LQY A;  1AJB A;  3WBH A;  1SHQ A;  2RH6 A;  1ELZ A;  1EI6 A;  5LIA A;  1ALJ A;  3Q3Q A;  5EGH A;  5IJS A;  3MK1 A;  4LR7 A;  3KD8 A;  4UOR A;  2GSN A;  1P49 A;  2VQR A;  3WAX A;  5INH A;  4GTW A;  3TG0 A;  5LRN A;  4MIV A;  3M7V A;  4UPL A;  2GLQ A;  2W8S A;  5KXA A;  5HRT A;  4LR2 A;  3UN3 A;  4CXU A;  5DLV A;  5L0K A;  1HQA A;  5K4P A;  5GRR A;  1AJD A;  3NKP A;  2W8D A;  3NKR A;  2W5R A;  4LRB A;  4KM4 A;  1ED8 A;  4B56 A;  2W5Q A;  1EW2 A;  1KHL A;  1Y6V A;  4CYS A;  3NKN A;  3WAW A;  4FDJ A;  3E2D A;  3UN2 A;  2D1G A;  4MY4 A;  5LQQ A;  1EJJ A;  4GTX A;  3MK2 A;  4LR9 A;  3BDF A;  4LR8 A;  4NWX A;  1ED9 A;  1ELY A;  3TX0 A;  1EQJ A;  4KAY A;  3NKQ A;  4ZGA A;  1ALH A;  1Y7A A;  2GSU A;  3CMR A;  4UPK A;  1FSU A;  4NWJ A;  3UO0 A;  3NVL A;  2W5S A;  3UN5 A;  2IUC A;  4FDI A;  5IJQ A;  4YR1 A;  2W5V A;  1AJA A;  4KAV A;  5DLW A;  4UPH A;  1URB A;  3UNY A;  4LRA A;  3SZY A;  2IUC B;  3SZZ A;  3M8Y A;  4LRF A;  3TWZ A;  1KH7 A;  4KJG A;  3DYC A;  5EGE A;  2GSO A;  4N7T A;  4LRE A;  1KHJ A;  3NKM A;  1E1Z P;  3T01 A;  3NKO A;  3WAV A;  3BDG A;  4LRC A;  1E33 P;  5L0B A;  1KHK A;  3B5Q A;  2XRG A;  5AJ9 A;  2W5X A; 
#chains in the Genus database with same CATH homology
 4MHX A;  3BDG B;  4QAX A;  1SHN A;  2GA3 A;  5L0E A;  3M8Z A;  1KH9 A;  2W5W A;  1AJC A;  4GTZ A;  5C66 A;  2XR9 A;  4TN0 A;  1URA A;  4CYR A;  1HDH A;  2ZKT A;  3WAY A;  4ZG9 A;  1KH5 A;  1KHN A;  2X98 A;  3ED4 A;  3IGZ B;  1ANJ A;  4KJD A;  4UOO A;  1N2L A;  3DPC A;  1ZED A;  3T02 A;  4UOP A;  2IFY A;  1E3C P;  4ZG7 A;  2QZU A;  1ANI A;  3IDD A;  1O99 A;  1AUK A;  1K7H A;  1ALK A;  4GTY A;  3IGY B;  2ANH A;  1O98 A;  1ALI A;  4CXK A;  1ZEB A;  3OT9 A;  4LRD A;  3BDH A;  4UPI A;  3M8W A;  1ELX A;  1N2K A;  1KH4 A;  5DLT A;  2G9Y A;  1EW8 A;  1HJK A;  4ZG6 A;  3LXQ A;  3A52 A;  5GOV A;  1EW9 A;  3T00 A;  1B8J A;  4CXS A;  1ZEF A;  5TJ3 A;  1E2S P;  2W5T A;  3MK0 A;  5LRM A;  4LQY A;  1AJB A;  3WBH A;  1SHQ A;  2RH6 A;  1ELZ A;  1EI6 A;  5LIA A;  1ALJ A;  3Q3Q A;  5EGH A;  5IJS A;  3MK1 A;  4LR7 A;  3KD8 A;  4UOR A;  2GSN A;  1P49 A;  2VQR A;  3WAX A;  5INH A;  4GTW A;  3TG0 A;  5LRN A;  4MIV A;  3M7V A;  4UPL A;  2GLQ A;  2W8S A;  5KXA A;  5HRT A;  4LR2 A;  3UN3 A;  4CXU A;  5DLV A;  5L0K A;  1HQA A;  5K4P A;  5GRR A;  1AJD A;  3NKP A;  2W8D A;  3NKR A;  2W5R A;  4LRB A;  4KM4 A;  1ED8 A;  4B56 A;  2W5Q A;  1EW2 A;  1KHL A;  1Y6V A;  4CYS A;  3NKN A;  3WAW A;  4FDJ A;  3E2D A;  3UN2 A;  2D1G A;  4MY4 A;  5LQQ A;  1EJJ A;  4GTX A;  3MK2 A;  4LR9 A;  3BDF A;  4LR8 A;  4NWX A;  1ED9 A;  1ELY A;  3TX0 A;  1EQJ A;  4KAY A;  3NKQ A;  4ZGA A;  1ALH A;  1Y7A A;  2GSU A;  3CMR A;  4UPK A;  1FSU A;  4NWJ A;  3UO0 A;  3NVL A;  2W5S A;  3UN5 A;  2IUC A;  4FDI A;  5IJQ A;  4YR1 A;  2W5V A;  1AJA A;  4KAV A;  5DLW A;  4UPH A;  1URB A;  3UNY A;  4LRA A;  3SZY A;  2IUC B;  3SZZ A;  3M8Y A;  4LRF A;  3TWZ A;  1KH7 A;  4KJG A;  3DYC A;  5EGE A;  2GSO A;  4N7T A;  4LRE A;  1KHJ A;  3NKM A;  1E1Z P;  3T01 A;  3NKO A;  3WAV A;  3BDG A;  4LRC A;  1E33 P;  5L0B A;  1KHK A;  3B5Q A;  2XRG A;  5AJ9 A;  2W5X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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