5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
4LRFA 3UNYA 3T02A 3MK0A 4UOOA 1EW9A 1EW8A 4KJDA 4LRAA 3ED4A 1K7HA 5GRRA 5L0EA 5L0KA 1ANIA 1ELYA 1HQAA 2ZKTA 2W5WA 3IGZB 4LQYA 3T01A 2W5TA 1E3CP 5LRMA 2W8SA 3WAYA 1Y7AA 1ZEDA 3M7VA 4CXSA 3WAVA 4KAVA 4YR1A 3TWZA 1E1ZP 3E2DA 5AJ9A 3IDDA 2W5SA 3IGYB 2GA3A 1Y6VA 4GTWA 3T00A 3UN2A 4MY4A 3CMRA 3SZZA 4N7TA 2XRGA 4MIVA 3NKQA 2XR9A 4KJGA 1ALKA 4UPHA 3NKRA 4CXKA 3Q3QA 4NWXA 5LQQA 4GTYA 2GSUA 1AJCA 1P49A 1KH5A 3B5QA 5HRTA 1EJJA 1ZEBA 3DYCA 4UPKA 5DLTA 4UPLA 1ED8A 1KH7A 1AJAA 3TX0A 4LRDA 4UORA 3OT9A 4ZG9A 1E33P 1ANJA 1FSUA 3DPCA 2GSNA 2W5VA 4CXUA 4LR9A 3BDHA 4KAYA 5INHA 2ANHA 3NKMA 1KHKA 3BDGA 1EI6A 1KH4A 1ELZA 5EGEA 5LRNA 4LR7A 1ALIA 1AUKA 2VQRA 1KHJA 3UN3A 5L0BA 3UN5A 5LIAA 1HDHA 4QAXA 1ELXA 3KD8A 2GSOA 3NVLA 1AJDA 3NKNA 3M8ZA 3WBHA 3NKOA 1KHNA 2W5QA 4CYSA 2W5RA 3BDGB 2IUCB 3LXQA 5C66A 5K4PA 4ZG6A 1ALJA 3SZYA 3NKPA 1URAA 2QZUA 5IJSA 4UPIA 1ED9A 3M8YA 4TN0A 4GTXA 4LRCA 4UOPA 4MHXA 5EGHA 4GTZA 3WAWA 5TJ3A 2D1GA 1EW2A 4B56A 4NWJA 4ZG7A 2IUCA 1AJBA 5GOVA 2RH6A 4ZGAA 4LRBA 2X98A 3WAXA 1HJKA 4FDJA 5KXAA 1EQJA 3A52A 3MK1A 2W5XA 4FDIA 4KM4A 5IJQA 1N2LA 4CYRA 3UO0A 1SHNA 1O98A 1KH9A 1N2KA 1SHQA 2W8DA 3TG0A 3BDFA 5DLWA 3MK2A 1E2SP 1O99A 2GLQA 4LR8A 3M8WA 2IFYA 1ZEFA 4LREA 4LR2A 5DLVA 2G9YA 1KHLA 1B8JA 1URBA 1ALHA
chains in the Genus database with same CATH superfamily
4LRFA 3UNYA 3T02A 3MK0A 4UOOA 1EW9A 1EW8A 4KJDA 4LRAA 3ED4A 1K7HA 5GRRA 5L0EA 5L0KA 1ANIA 1ELYA 1HQAA 2ZKTA 2W5WA 3IGZB 4LQYA 3T01A 2W5TA 1E3CP 5LRMA 2W8SA 3WAYA 1Y7AA 1ZEDA 3M7VA 4CXSA 3WAVA 4KAVA 4YR1A 3TWZA 1E1ZP 3E2DA 5AJ9A 3IDDA 2W5SA 3IGYB 2GA3A 1Y6VA 4GTWA 3T00A 3UN2A 4MY4A 3CMRA 3SZZA 4N7TA 2XRGA 4MIVA 3NKQA 2XR9A 4KJGA 1ALKA 4UPHA 3NKRA 4CXKA 3Q3QA 4NWXA 5LQQA 4GTYA 2GSUA 1AJCA 1P49A 1KH5A 3B5QA 5HRTA 1EJJA 1ZEBA 3DYCA 4UPKA 5DLTA 4UPLA 1ED8A 1KH7A 1AJAA 3TX0A 4LRDA 4UORA 3OT9A 4ZG9A 1E33P 1ANJA 1FSUA 3DPCA 2GSNA 2W5VA 4CXUA 4LR9A 3BDHA 4KAYA 5INHA 2ANHA 3NKMA 1KHKA 3BDGA 1EI6A 1KH4A 1ELZA 5EGEA 5LRNA 4LR7A 1ALIA 1AUKA 2VQRA 1KHJA 3UN3A 5L0BA 3UN5A 5LIAA 1HDHA 4QAXA 1ELXA 3KD8A 2GSOA 3NVLA 1AJDA 3NKNA 3M8ZA 3WBHA 3NKOA 1KHNA 2W5QA 4CYSA 2W5RA 3BDGB 2IUCB 3LXQA 5C66A 5K4PA 4ZG6A 1ALJA 3SZYA 3NKPA 1URAA 2QZUA 5IJSA 4UPIA 1ED9A 3M8YA 4TN0A 4GTXA 4LRCA 4UOPA 4MHXA 5EGHA 4GTZA 3WAWA 5TJ3A 2D1GA 1EW2A 4B56A 4NWJA 4ZG7A 2IUCA 1AJBA 5GOVA 2RH6A 4ZGAA 4LRBA 2X98A 3WAXA 1HJKA 4FDJA 5KXAA 1EQJA 3A52A 3MK1A 2W5XA 4FDIA 4KM4A 5IJQA 1N2LA 4CYRA 3UO0A 1SHNA 1O98A 1KH9A 1N2KA 1SHQA 2W8DA 3TG0A 3BDFA 5DLWA 3MK2A 1E2SP 1O99A 2GLQA 4LR8A 3M8WA 2IFYA 1ZEFA 4LREA 4LR2A 5DLVA 2G9YA 1KHLA 1B8JA 1URBA 1ALHA
chains in the Genus database with same CATH topology
4LRFA 3UNYA 3T02A 3MK0A 4UOOA 1EW9A 1EW8A 4KJDA 4LRAA 3ED4A 1K7HA 5GRRA 5L0EA 5L0KA 1ANIA 1ELYA 1HQAA 2ZKTA 2W5WA 3IGZB 4LQYA 3T01A 2W5TA 1E3CP 5LRMA 2W8SA 3WAYA 1Y7AA 1ZEDA 3M7VA 4CXSA 3WAVA 4KAVA 4YR1A 3TWZA 1E1ZP 3E2DA 5AJ9A 3IDDA 2W5SA 3IGYB 2GA3A 1Y6VA 4GTWA 3T00A 3UN2A 4MY4A 3CMRA 3SZZA 4N7TA 2XRGA 4MIVA 3NKQA 2XR9A 4KJGA 1ALKA 4UPHA 3NKRA 4CXKA 3Q3QA 4NWXA 5LQQA 4GTYA 2GSUA 1AJCA 1P49A 1KH5A 3B5QA 5HRTA 1EJJA 1ZEBA 3DYCA 4UPKA 5DLTA 4UPLA 1ED8A 1KH7A 1AJAA 3TX0A 4LRDA 4UORA 3OT9A 4ZG9A 1E33P 1ANJA 1FSUA 3DPCA 2GSNA 2W5VA 4CXUA 4LR9A 3BDHA 4KAYA 5INHA 2ANHA 3NKMA 1KHKA 3BDGA 1EI6A 1KH4A 1ELZA 5EGEA 5LRNA 4LR7A 1ALIA 1AUKA 2VQRA 1KHJA 3UN3A 5L0BA 3UN5A 5LIAA 1HDHA 4QAXA 1ELXA 3KD8A 2GSOA 3NVLA 1AJDA 3NKNA 3M8ZA 3WBHA 3NKOA 1KHNA 2W5QA 4CYSA 2W5RA 3BDGB 2IUCB 3LXQA 5C66A 5K4PA 4ZG6A 1ALJA 3SZYA 3NKPA 1URAA 2QZUA 5IJSA 4UPIA 1ED9A 3M8YA 4TN0A 4GTXA 4LRCA 4UOPA 4MHXA 5EGHA 4GTZA 3WAWA 5TJ3A 2D1GA 1EW2A 4B56A 4NWJA 4ZG7A 2IUCA 1AJBA 5GOVA 2RH6A 4ZGAA 4LRBA 2X98A 3WAXA 1HJKA 4FDJA 5KXAA 1EQJA 3A52A 3MK1A 2W5XA 4FDIA 4KM4A 5IJQA 1N2LA 4CYRA 3UO0A 1SHNA 1O98A 1KH9A 1N2KA 1SHQA 2W8DA 3TG0A 3BDFA 5DLWA 3MK2A 1E2SP 1O99A 2GLQA 4LR8A 3M8WA 2IFYA 1ZEFA 4LREA 4LR2A 5DLVA 2G9YA 1KHLA 1B8JA 1URBA 1ALHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LRF A;  3UNY A;  3T02 A;  3MK0 A;  4UOO A;  1EW9 A;  1EW8 A;  4KJD A;  4LRA A;  3ED4 A;  1K7H A;  5GRR A;  5L0E A;  5L0K A;  1ANI A;  1ELY A;  1HQA A;  2ZKT A;  2W5W A;  3IGZ B;  4LQY A;  3T01 A;  2W5T A;  1E3C P;  5LRM A;  2W8S A;  3WAY A;  1Y7A A;  1ZED A;  3M7V A;  4CXS A;  3WAV A;  4KAV A;  4YR1 A;  3TWZ A;  1E1Z P;  3E2D A;  5AJ9 A;  3IDD A;  2W5S A;  3IGY B;  2GA3 A;  1Y6V A;  4GTW A;  3T00 A;  3UN2 A;  4MY4 A;  3CMR A;  3SZZ A;  4N7T A;  2XRG A;  4MIV A;  3NKQ A;  2XR9 A;  4KJG A;  1ALK A;  4UPH A;  3NKR A;  4CXK A;  3Q3Q A;  4NWX A;  5LQQ A;  4GTY A;  2GSU A;  1AJC A;  1P49 A;  1KH5 A;  3B5Q A;  5HRT A;  1EJJ A;  1ZEB A;  3DYC A;  4UPK A;  5DLT A;  4UPL A;  1ED8 A;  1KH7 A;  1AJA A;  3TX0 A;  4LRD A;  4UOR A;  3OT9 A;  4ZG9 A;  1E33 P;  1ANJ A;  1FSU A;  3DPC A;  2GSN A;  2W5V A;  4CXU A;  4LR9 A;  3BDH A;  4KAY A;  5INH A;  2ANH A;  3NKM A;  1KHK A;  3BDG A;  1EI6 A;  1KH4 A;  1ELZ A;  5EGE A;  5LRN A;  4LR7 A;  1ALI A;  1AUK A;  2VQR A;  1KHJ A;  3UN3 A;  5L0B A;  3UN5 A;  5LIA A;  1HDH A;  4QAX A;  1ELX A;  3KD8 A;  2GSO A;  3NVL A;  1AJD A;  3NKN A;  3M8Z A;  3WBH A;  3NKO A;  1KHN A;  2W5Q A;  4CYS A;  2W5R A;  3BDG B;  2IUC B;  3LXQ A;  5C66 A;  5K4P A;  4ZG6 A;  1ALJ A;  3SZY A;  3NKP A;  1URA A;  2QZU A;  5IJS A;  4UPI A;  1ED9 A;  3M8Y A;  4TN0 A;  4GTX A;  4LRC A;  4UOP A;  4MHX A;  5EGH A;  4GTZ A;  3WAW A;  5TJ3 A;  2D1G A;  1EW2 A;  4B56 A;  4NWJ A;  4ZG7 A;  2IUC A;  1AJB A;  5GOV A;  2RH6 A;  4ZGA A;  4LRB A;  2X98 A;  3WAX A;  1HJK A;  4FDJ A;  5KXA A;  1EQJ A;  3A52 A;  3MK1 A;  2W5X A;  4FDI A;  4KM4 A;  5IJQ A;  1N2L A;  4CYR A;  3UO0 A;  1SHN A;  1O98 A;  1KH9 A;  1N2K A;  1SHQ A;  2W8D A;  3TG0 A;  3BDF A;  5DLW A;  3MK2 A;  1E2S P;  1O99 A;  2GLQ A;  4LR8 A;  3M8W A;  2IFY A;  1ZEF A;  4LRE A;  4LR2 A;  5DLV A;  2G9Y A;  1KHL A;  1B8J A;  1URB A;  1ALH A; 
#chains in the Genus database with same CATH topology
 4LRF A;  3UNY A;  3T02 A;  3MK0 A;  4UOO A;  1EW9 A;  1EW8 A;  4KJD A;  4LRA A;  3ED4 A;  1K7H A;  5GRR A;  5L0E A;  5L0K A;  1ANI A;  1ELY A;  1HQA A;  2ZKT A;  2W5W A;  3IGZ B;  4LQY A;  3T01 A;  2W5T A;  1E3C P;  5LRM A;  2W8S A;  3WAY A;  1Y7A A;  1ZED A;  3M7V A;  4CXS A;  3WAV A;  4KAV A;  4YR1 A;  3TWZ A;  1E1Z P;  3E2D A;  5AJ9 A;  3IDD A;  2W5S A;  3IGY B;  2GA3 A;  1Y6V A;  4GTW A;  3T00 A;  3UN2 A;  4MY4 A;  3CMR A;  3SZZ A;  4N7T A;  2XRG A;  4MIV A;  3NKQ A;  2XR9 A;  4KJG A;  1ALK A;  4UPH A;  3NKR A;  4CXK A;  3Q3Q A;  4NWX A;  5LQQ A;  4GTY A;  2GSU A;  1AJC A;  1P49 A;  1KH5 A;  3B5Q A;  5HRT A;  1EJJ A;  1ZEB A;  3DYC A;  4UPK A;  5DLT A;  4UPL A;  1ED8 A;  1KH7 A;  1AJA A;  3TX0 A;  4LRD A;  4UOR A;  3OT9 A;  4ZG9 A;  1E33 P;  1ANJ A;  1FSU A;  3DPC A;  2GSN A;  2W5V A;  4CXU A;  4LR9 A;  3BDH A;  4KAY A;  5INH A;  2ANH A;  3NKM A;  1KHK A;  3BDG A;  1EI6 A;  1KH4 A;  1ELZ A;  5EGE A;  5LRN A;  4LR7 A;  1ALI A;  1AUK A;  2VQR A;  1KHJ A;  3UN3 A;  5L0B A;  3UN5 A;  5LIA A;  1HDH A;  4QAX A;  1ELX A;  3KD8 A;  2GSO A;  3NVL A;  1AJD A;  3NKN A;  3M8Z A;  3WBH A;  3NKO A;  1KHN A;  2W5Q A;  4CYS A;  2W5R A;  3BDG B;  2IUC B;  3LXQ A;  5C66 A;  5K4P A;  4ZG6 A;  1ALJ A;  3SZY A;  3NKP A;  1URA A;  2QZU A;  5IJS A;  4UPI A;  1ED9 A;  3M8Y A;  4TN0 A;  4GTX A;  4LRC A;  4UOP A;  4MHX A;  5EGH A;  4GTZ A;  3WAW A;  5TJ3 A;  2D1G A;  1EW2 A;  4B56 A;  4NWJ A;  4ZG7 A;  2IUC A;  1AJB A;  5GOV A;  2RH6 A;  4ZGA A;  4LRB A;  2X98 A;  3WAX A;  1HJK A;  4FDJ A;  5KXA A;  1EQJ A;  3A52 A;  3MK1 A;  2W5X A;  4FDI A;  4KM4 A;  5IJQ A;  1N2L A;  4CYR A;  3UO0 A;  1SHN A;  1O98 A;  1KH9 A;  1N2K A;  1SHQ A;  2W8D A;  3TG0 A;  3BDF A;  5DLW A;  3MK2 A;  1E2S P;  1O99 A;  2GLQ A;  4LR8 A;  3M8W A;  2IFY A;  1ZEF A;  4LRE A;  4LR2 A;  5DLV A;  2G9Y A;  1KHL A;  1B8J A;  1URB A;  1ALH A; 
#chains in the Genus database with same CATH homology
 4LRF A;  3UNY A;  3T02 A;  3MK0 A;  4UOO A;  1EW9 A;  1EW8 A;  4KJD A;  4LRA A;  3ED4 A;  1K7H A;  5GRR A;  5L0E A;  5L0K A;  1ANI A;  1ELY A;  1HQA A;  2ZKT A;  2W5W A;  3IGZ B;  4LQY A;  3T01 A;  2W5T A;  1E3C P;  5LRM A;  2W8S A;  3WAY A;  1Y7A A;  1ZED A;  3M7V A;  4CXS A;  3WAV A;  4KAV A;  4YR1 A;  3TWZ A;  1E1Z P;  3E2D A;  5AJ9 A;  3IDD A;  2W5S A;  3IGY B;  2GA3 A;  1Y6V A;  4GTW A;  3T00 A;  3UN2 A;  4MY4 A;  3CMR A;  3SZZ A;  4N7T A;  2XRG A;  4MIV A;  3NKQ A;  2XR9 A;  4KJG A;  1ALK A;  4UPH A;  3NKR A;  4CXK A;  3Q3Q A;  4NWX A;  5LQQ A;  4GTY A;  2GSU A;  1AJC A;  1P49 A;  1KH5 A;  3B5Q A;  5HRT A;  1EJJ A;  1ZEB A;  3DYC A;  4UPK A;  5DLT A;  4UPL A;  1ED8 A;  1KH7 A;  1AJA A;  3TX0 A;  4LRD A;  4UOR A;  3OT9 A;  4ZG9 A;  1E33 P;  1ANJ A;  1FSU A;  3DPC A;  2GSN A;  2W5V A;  4CXU A;  4LR9 A;  3BDH A;  4KAY A;  5INH A;  2ANH A;  3NKM A;  1KHK A;  3BDG A;  1EI6 A;  1KH4 A;  1ELZ A;  5EGE A;  5LRN A;  4LR7 A;  1ALI A;  1AUK A;  2VQR A;  1KHJ A;  3UN3 A;  5L0B A;  3UN5 A;  5LIA A;  1HDH A;  4QAX A;  1ELX A;  3KD8 A;  2GSO A;  3NVL A;  1AJD A;  3NKN A;  3M8Z A;  3WBH A;  3NKO A;  1KHN A;  2W5Q A;  4CYS A;  2W5R A;  3BDG B;  2IUC B;  3LXQ A;  5C66 A;  5K4P A;  4ZG6 A;  1ALJ A;  3SZY A;  3NKP A;  1URA A;  2QZU A;  5IJS A;  4UPI A;  1ED9 A;  3M8Y A;  4TN0 A;  4GTX A;  4LRC A;  4UOP A;  4MHX A;  5EGH A;  4GTZ A;  3WAW A;  5TJ3 A;  2D1G A;  1EW2 A;  4B56 A;  4NWJ A;  4ZG7 A;  2IUC A;  1AJB A;  5GOV A;  2RH6 A;  4ZGA A;  4LRB A;  2X98 A;  3WAX A;  1HJK A;  4FDJ A;  5KXA A;  1EQJ A;  3A52 A;  3MK1 A;  2W5X A;  4FDI A;  4KM4 A;  5IJQ A;  1N2L A;  4CYR A;  3UO0 A;  1SHN A;  1O98 A;  1KH9 A;  1N2K A;  1SHQ A;  2W8D A;  3TG0 A;  3BDF A;  5DLW A;  3MK2 A;  1E2S P;  1O99 A;  2GLQ A;  4LR8 A;  3M8W A;  2IFY A;  1ZEF A;  4LRE A;  4LR2 A;  5DLV A;  2G9Y A;  1KHL A;  1B8J A;  1URB A;  1ALH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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