5C66A

E. coli alkaline phosphatase in complex with tungstate
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
441
structure length
441
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Tungstate as a Transition State Analog for Catalysis by Alkaline Phosphatase.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 161
structure length 441
sequence length 441
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-06-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 5c66A00
1ALIA 3BDGA 4GTZA 3M8ZA 5DLWA 3SZYA 5KXAA 1E1ZP 1N2LA 5C66A 1ALHA 3NKMA 1E2SP 5LRNA 1KHKA 4LRAA 3UN2A 1EJJA 3IGZB 1ZEFA 5L0KA 1N2KA 2IUCA 4YR1A 5GOVA 4KAYA 1O99A 5GRRA 3MK1A 5AJ9A 1AJDA 1EW9A 1ANJA 3UN3A 3NKPA 3ED4A 5LIAA 3TWZA 2W8SA 1SHQA 4LRCA 3LXQA 4NWXA 1ED9A 1KHLA 3T01A 3T02A 2ANHA 4UOOA 3M8YA 3A52A 4CYRA 4UOPA 5EGEA 2ZKTA 4UPHA 3E2DA 2RH6A 3NKRA 1AUKA 2IFYA 3IDDA 1ELXA 3NVLA 2GLQA 1AJCA 4MIVA 2W8DA 2GSUA 4GTXA 5DLVA 3NKOA 3OT9A 2X98A 3CMRA 1E33P 4CXKA 2W5RA 4CXSA 2G9YA 1AJAA 4B56A 2IUCB 2XRGA 3WAWA 1ZEBA 5L0EA 4TN0A 3WBHA 4KAVA 4LREA 1URBA 4LQYA 2W5QA 1HDHA 4ZGAA 5IJQA 3MK0A 1HJKA 4LR7A 4MY4A 3BDFA 1P49A 3SZZA 1ZEDA 3UN5A 4GTYA 1SHNA 3DYCA 4FDIA 1ELYA 3M8WA 3NKNA 1ED8A 3Q3QA 4KJDA 3UO0A 4NWJA 3WAXA 5DLTA 4KM4A 1KH7A 1EW2A 4CXUA 2GA3A 1O98A 4GTWA 3KD8A 4LRFA 5HRTA 5IJSA 2W5XA 3TG0A 1KH5A 2GSOA 4LRDA 1HQAA 4UPLA 4LR2A 4LR9A 3NKQA 5LQQA 3MK2A 4FDJA 1ALKA 2GSNA 1EW8A 4LR8A 1E3CP 1EQJA 1ANIA 3BDHA 5EGHA 1EI6A 3TX0A 1KHJA 4ZG9A 1B8JA 3DPCA 2W5WA 3B5QA 4ZG6A 2D1GA 1ALJA 1KH4A 5K4PA 2W5SA 1Y7AA 2VQRA 2W5TA 4CYSA 3UNYA 2W5VA 3BDGB 4KJGA 4N7TA 4QAXA 5INHA 1KH9A 1URAA 2XR9A 4LRBA 4UPKA 4ZG7A 3M7VA 1K7HA 1FSUA 3WAYA 4UPIA 3T00A 1Y6VA 4UORA 1ELZA 5L0BA 5TJ3A 3WAVA 3IGYB 2QZUA 1KHNA 5LRMA 4MHXA 1AJBA
chains in the Genus database with same CATH superfamily
1ALIA 3BDGA 4GTZA 3M8ZA 5DLWA 3SZYA 5KXAA 1E1ZP 1N2LA 5C66A 1ALHA 3NKMA 1E2SP 5LRNA 1KHKA 4LRAA 3UN2A 1EJJA 3IGZB 1ZEFA 5L0KA 1N2KA 2IUCA 4YR1A 5GOVA 4KAYA 1O99A 5GRRA 3MK1A 5AJ9A 1AJDA 1EW9A 1ANJA 3UN3A 3NKPA 3ED4A 5LIAA 3TWZA 2W8SA 1SHQA 4LRCA 3LXQA 4NWXA 1ED9A 1KHLA 3T01A 3T02A 2ANHA 4UOOA 3M8YA 3A52A 4CYRA 4UOPA 5EGEA 2ZKTA 4UPHA 3E2DA 2RH6A 3NKRA 1AUKA 2IFYA 3IDDA 1ELXA 3NVLA 2GLQA 1AJCA 4MIVA 2W8DA 2GSUA 4GTXA 5DLVA 3NKOA 3OT9A 2X98A 3CMRA 1E33P 4CXKA 2W5RA 4CXSA 2G9YA 1AJAA 4B56A 2IUCB 2XRGA 3WAWA 1ZEBA 5L0EA 4TN0A 3WBHA 4KAVA 4LREA 1URBA 4LQYA 2W5QA 1HDHA 4ZGAA 5IJQA 3MK0A 1HJKA 4LR7A 4MY4A 3BDFA 1P49A 3SZZA 1ZEDA 3UN5A 4GTYA 1SHNA 3DYCA 4FDIA 1ELYA 3M8WA 3NKNA 1ED8A 3Q3QA 4KJDA 3UO0A 4NWJA 3WAXA 5DLTA 4KM4A 1KH7A 1EW2A 4CXUA 2GA3A 1O98A 4GTWA 3KD8A 4LRFA 5HRTA 5IJSA 2W5XA 3TG0A 1KH5A 2GSOA 4LRDA 1HQAA 4UPLA 4LR2A 4LR9A 3NKQA 5LQQA 3MK2A 4FDJA 1ALKA 2GSNA 1EW8A 4LR8A 1E3CP 1EQJA 1ANIA 3BDHA 5EGHA 1EI6A 3TX0A 1KHJA 4ZG9A 1B8JA 3DPCA 2W5WA 3B5QA 4ZG6A 2D1GA 1ALJA 1KH4A 5K4PA 2W5SA 1Y7AA 2VQRA 2W5TA 4CYSA 3UNYA 2W5VA 3BDGB 4KJGA 4N7TA 4QAXA 5INHA 1KH9A 1URAA 2XR9A 4LRBA 4UPKA 4ZG7A 3M7VA 1K7HA 1FSUA 3WAYA 4UPIA 3T00A 1Y6VA 4UORA 1ELZA 5L0BA 5TJ3A 3WAVA 3IGYB 2QZUA 1KHNA 5LRMA 4MHXA 1AJBA
chains in the Genus database with same CATH topology
1ALIA 3BDGA 4GTZA 3M8ZA 5DLWA 3SZYA 5KXAA 1E1ZP 1N2LA 5C66A 1ALHA 3NKMA 1E2SP 5LRNA 1KHKA 4LRAA 3UN2A 1EJJA 3IGZB 1ZEFA 5L0KA 1N2KA 2IUCA 4YR1A 5GOVA 4KAYA 1O99A 5GRRA 3MK1A 5AJ9A 1AJDA 1EW9A 1ANJA 3UN3A 3NKPA 3ED4A 5LIAA 3TWZA 2W8SA 1SHQA 4LRCA 3LXQA 4NWXA 1ED9A 1KHLA 3T01A 3T02A 2ANHA 4UOOA 3M8YA 3A52A 4CYRA 4UOPA 5EGEA 2ZKTA 4UPHA 3E2DA 2RH6A 3NKRA 1AUKA 2IFYA 3IDDA 1ELXA 3NVLA 2GLQA 1AJCA 4MIVA 2W8DA 2GSUA 4GTXA 5DLVA 3NKOA 3OT9A 2X98A 3CMRA 1E33P 4CXKA 2W5RA 4CXSA 2G9YA 1AJAA 4B56A 2IUCB 2XRGA 3WAWA 1ZEBA 5L0EA 4TN0A 3WBHA 4KAVA 4LREA 1URBA 4LQYA 2W5QA 1HDHA 4ZGAA 5IJQA 3MK0A 1HJKA 4LR7A 4MY4A 3BDFA 1P49A 3SZZA 1ZEDA 3UN5A 4GTYA 1SHNA 3DYCA 4FDIA 1ELYA 3M8WA 3NKNA 1ED8A 3Q3QA 4KJDA 3UO0A 4NWJA 3WAXA 5DLTA 4KM4A 1KH7A 1EW2A 4CXUA 2GA3A 1O98A 4GTWA 3KD8A 4LRFA 5HRTA 5IJSA 2W5XA 3TG0A 1KH5A 2GSOA 4LRDA 1HQAA 4UPLA 4LR2A 4LR9A 3NKQA 5LQQA 3MK2A 4FDJA 1ALKA 2GSNA 1EW8A 4LR8A 1E3CP 1EQJA 1ANIA 3BDHA 5EGHA 1EI6A 3TX0A 1KHJA 4ZG9A 1B8JA 3DPCA 2W5WA 3B5QA 4ZG6A 2D1GA 1ALJA 1KH4A 5K4PA 2W5SA 1Y7AA 2VQRA 2W5TA 4CYSA 3UNYA 2W5VA 3BDGB 4KJGA 4N7TA 4QAXA 5INHA 1KH9A 1URAA 2XR9A 4LRBA 4UPKA 4ZG7A 3M7VA 1K7HA 1FSUA 3WAYA 4UPIA 3T00A 1Y6VA 4UORA 1ELZA 5L0BA 5TJ3A 3WAVA 3IGYB 2QZUA 1KHNA 5LRMA 4MHXA 1AJBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALI A;  3BDG A;  4GTZ A;  3M8Z A;  5DLW A;  3SZY A;  5KXA A;  1E1Z P;  1N2L A;  5C66 A;  1ALH A;  3NKM A;  1E2S P;  5LRN A;  1KHK A;  4LRA A;  3UN2 A;  1EJJ A;  3IGZ B;  1ZEF A;  5L0K A;  1N2K A;  2IUC A;  4YR1 A;  5GOV A;  4KAY A;  1O99 A;  5GRR A;  3MK1 A;  5AJ9 A;  1AJD A;  1EW9 A;  1ANJ A;  3UN3 A;  3NKP A;  3ED4 A;  5LIA A;  3TWZ A;  2W8S A;  1SHQ A;  4LRC A;  3LXQ A;  4NWX A;  1ED9 A;  1KHL A;  3T01 A;  3T02 A;  2ANH A;  4UOO A;  3M8Y A;  3A52 A;  4CYR A;  4UOP A;  5EGE A;  2ZKT A;  4UPH A;  3E2D A;  2RH6 A;  3NKR A;  1AUK A;  2IFY A;  3IDD A;  1ELX A;  3NVL A;  2GLQ A;  1AJC A;  4MIV A;  2W8D A;  2GSU A;  4GTX A;  5DLV A;  3NKO A;  3OT9 A;  2X98 A;  3CMR A;  1E33 P;  4CXK A;  2W5R A;  4CXS A;  2G9Y A;  1AJA A;  4B56 A;  2IUC B;  2XRG A;  3WAW A;  1ZEB A;  5L0E A;  4TN0 A;  3WBH A;  4KAV A;  4LRE A;  1URB A;  4LQY A;  2W5Q A;  1HDH A;  4ZGA A;  5IJQ A;  3MK0 A;  1HJK A;  4LR7 A;  4MY4 A;  3BDF A;  1P49 A;  3SZZ A;  1ZED A;  3UN5 A;  4GTY A;  1SHN A;  3DYC A;  4FDI A;  1ELY A;  3M8W A;  3NKN A;  1ED8 A;  3Q3Q A;  4KJD A;  3UO0 A;  4NWJ A;  3WAX A;  5DLT A;  4KM4 A;  1KH7 A;  1EW2 A;  4CXU A;  2GA3 A;  1O98 A;  4GTW A;  3KD8 A;  4LRF A;  5HRT A;  5IJS A;  2W5X A;  3TG0 A;  1KH5 A;  2GSO A;  4LRD A;  1HQA A;  4UPL A;  4LR2 A;  4LR9 A;  3NKQ A;  5LQQ A;  3MK2 A;  4FDJ A;  1ALK A;  2GSN A;  1EW8 A;  4LR8 A;  1E3C P;  1EQJ A;  1ANI A;  3BDH A;  5EGH A;  1EI6 A;  3TX0 A;  1KHJ A;  4ZG9 A;  1B8J A;  3DPC A;  2W5W A;  3B5Q A;  4ZG6 A;  2D1G A;  1ALJ A;  1KH4 A;  5K4P A;  2W5S A;  1Y7A A;  2VQR A;  2W5T A;  4CYS A;  3UNY A;  2W5V A;  3BDG B;  4KJG A;  4N7T A;  4QAX A;  5INH A;  1KH9 A;  1URA A;  2XR9 A;  4LRB A;  4UPK A;  4ZG7 A;  3M7V A;  1K7H A;  1FSU A;  3WAY A;  4UPI A;  3T00 A;  1Y6V A;  4UOR A;  1ELZ A;  5L0B A;  5TJ3 A;  3WAV A;  3IGY B;  2QZU A;  1KHN A;  5LRM A;  4MHX A;  1AJB A; 
#chains in the Genus database with same CATH topology
 1ALI A;  3BDG A;  4GTZ A;  3M8Z A;  5DLW A;  3SZY A;  5KXA A;  1E1Z P;  1N2L A;  5C66 A;  1ALH A;  3NKM A;  1E2S P;  5LRN A;  1KHK A;  4LRA A;  3UN2 A;  1EJJ A;  3IGZ B;  1ZEF A;  5L0K A;  1N2K A;  2IUC A;  4YR1 A;  5GOV A;  4KAY A;  1O99 A;  5GRR A;  3MK1 A;  5AJ9 A;  1AJD A;  1EW9 A;  1ANJ A;  3UN3 A;  3NKP A;  3ED4 A;  5LIA A;  3TWZ A;  2W8S A;  1SHQ A;  4LRC A;  3LXQ A;  4NWX A;  1ED9 A;  1KHL A;  3T01 A;  3T02 A;  2ANH A;  4UOO A;  3M8Y A;  3A52 A;  4CYR A;  4UOP A;  5EGE A;  2ZKT A;  4UPH A;  3E2D A;  2RH6 A;  3NKR A;  1AUK A;  2IFY A;  3IDD A;  1ELX A;  3NVL A;  2GLQ A;  1AJC A;  4MIV A;  2W8D A;  2GSU A;  4GTX A;  5DLV A;  3NKO A;  3OT9 A;  2X98 A;  3CMR A;  1E33 P;  4CXK A;  2W5R A;  4CXS A;  2G9Y A;  1AJA A;  4B56 A;  2IUC B;  2XRG A;  3WAW A;  1ZEB A;  5L0E A;  4TN0 A;  3WBH A;  4KAV A;  4LRE A;  1URB A;  4LQY A;  2W5Q A;  1HDH A;  4ZGA A;  5IJQ A;  3MK0 A;  1HJK A;  4LR7 A;  4MY4 A;  3BDF A;  1P49 A;  3SZZ A;  1ZED A;  3UN5 A;  4GTY A;  1SHN A;  3DYC A;  4FDI A;  1ELY A;  3M8W A;  3NKN A;  1ED8 A;  3Q3Q A;  4KJD A;  3UO0 A;  4NWJ A;  3WAX A;  5DLT A;  4KM4 A;  1KH7 A;  1EW2 A;  4CXU A;  2GA3 A;  1O98 A;  4GTW A;  3KD8 A;  4LRF A;  5HRT A;  5IJS A;  2W5X A;  3TG0 A;  1KH5 A;  2GSO A;  4LRD A;  1HQA A;  4UPL A;  4LR2 A;  4LR9 A;  3NKQ A;  5LQQ A;  3MK2 A;  4FDJ A;  1ALK A;  2GSN A;  1EW8 A;  4LR8 A;  1E3C P;  1EQJ A;  1ANI A;  3BDH A;  5EGH A;  1EI6 A;  3TX0 A;  1KHJ A;  4ZG9 A;  1B8J A;  3DPC A;  2W5W A;  3B5Q A;  4ZG6 A;  2D1G A;  1ALJ A;  1KH4 A;  5K4P A;  2W5S A;  1Y7A A;  2VQR A;  2W5T A;  4CYS A;  3UNY A;  2W5V A;  3BDG B;  4KJG A;  4N7T A;  4QAX A;  5INH A;  1KH9 A;  1URA A;  2XR9 A;  4LRB A;  4UPK A;  4ZG7 A;  3M7V A;  1K7H A;  1FSU A;  3WAY A;  4UPI A;  3T00 A;  1Y6V A;  4UOR A;  1ELZ A;  5L0B A;  5TJ3 A;  3WAV A;  3IGY B;  2QZU A;  1KHN A;  5LRM A;  4MHX A;  1AJB A; 
#chains in the Genus database with same CATH homology
 1ALI A;  3BDG A;  4GTZ A;  3M8Z A;  5DLW A;  3SZY A;  5KXA A;  1E1Z P;  1N2L A;  5C66 A;  1ALH A;  3NKM A;  1E2S P;  5LRN A;  1KHK A;  4LRA A;  3UN2 A;  1EJJ A;  3IGZ B;  1ZEF A;  5L0K A;  1N2K A;  2IUC A;  4YR1 A;  5GOV A;  4KAY A;  1O99 A;  5GRR A;  3MK1 A;  5AJ9 A;  1AJD A;  1EW9 A;  1ANJ A;  3UN3 A;  3NKP A;  3ED4 A;  5LIA A;  3TWZ A;  2W8S A;  1SHQ A;  4LRC A;  3LXQ A;  4NWX A;  1ED9 A;  1KHL A;  3T01 A;  3T02 A;  2ANH A;  4UOO A;  3M8Y A;  3A52 A;  4CYR A;  4UOP A;  5EGE A;  2ZKT A;  4UPH A;  3E2D A;  2RH6 A;  3NKR A;  1AUK A;  2IFY A;  3IDD A;  1ELX A;  3NVL A;  2GLQ A;  1AJC A;  4MIV A;  2W8D A;  2GSU A;  4GTX A;  5DLV A;  3NKO A;  3OT9 A;  2X98 A;  3CMR A;  1E33 P;  4CXK A;  2W5R A;  4CXS A;  2G9Y A;  1AJA A;  4B56 A;  2IUC B;  2XRG A;  3WAW A;  1ZEB A;  5L0E A;  4TN0 A;  3WBH A;  4KAV A;  4LRE A;  1URB A;  4LQY A;  2W5Q A;  1HDH A;  4ZGA A;  5IJQ A;  3MK0 A;  1HJK A;  4LR7 A;  4MY4 A;  3BDF A;  1P49 A;  3SZZ A;  1ZED A;  3UN5 A;  4GTY A;  1SHN A;  3DYC A;  4FDI A;  1ELY A;  3M8W A;  3NKN A;  1ED8 A;  3Q3Q A;  4KJD A;  3UO0 A;  4NWJ A;  3WAX A;  5DLT A;  4KM4 A;  1KH7 A;  1EW2 A;  4CXU A;  2GA3 A;  1O98 A;  4GTW A;  3KD8 A;  4LRF A;  5HRT A;  5IJS A;  2W5X A;  3TG0 A;  1KH5 A;  2GSO A;  4LRD A;  1HQA A;  4UPL A;  4LR2 A;  4LR9 A;  3NKQ A;  5LQQ A;  3MK2 A;  4FDJ A;  1ALK A;  2GSN A;  1EW8 A;  4LR8 A;  1E3C P;  1EQJ A;  1ANI A;  3BDH A;  5EGH A;  1EI6 A;  3TX0 A;  1KHJ A;  4ZG9 A;  1B8J A;  3DPC A;  2W5W A;  3B5Q A;  4ZG6 A;  2D1G A;  1ALJ A;  1KH4 A;  5K4P A;  2W5S A;  1Y7A A;  2VQR A;  2W5T A;  4CYS A;  3UNY A;  2W5V A;  3BDG B;  4KJG A;  4N7T A;  4QAX A;  5INH A;  1KH9 A;  1URA A;  2XR9 A;  4LRB A;  4UPK A;  4ZG7 A;  3M7V A;  1K7H A;  1FSU A;  3WAY A;  4UPI A;  3T00 A;  1Y6V A;  4UOR A;  1ELZ A;  5L0B A;  5TJ3 A;  3WAV A;  3IGY B;  2QZU A;  1KHN A;  5LRM A;  4MHX A;  1AJB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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