1Y7AA

Structure of d153h/k328w e. coli alkaline phosphatase in presence of cobalt at 1.77 a resolution
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDWQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y7aA00
1EJJA 1B8JA 4UPKA 3WAWA 1ALJA 3M8WA 1KH5A 4NWXA 3SZZA 5TJ3A 3E2DA 5INHA 1ELYA 4UOOA 4ZG6A 3OT9A 1ANJA 1EW9A 1URAA 4KAYA 1ZEBA 4KM4A 3A52A 3IGYB 4LREA 2IUCA 4LR9A 5HRTA 5GOVA 1E3CP 2RH6A 4UPIA 1HJKA 5LIAA 1K7HA 2W8SA 4MIVA 3UNYA 4LR2A 4CXSA 3UO0A 1KH4A 3LXQA 2XR9A 3KD8A 3MK1A 3MK0A 2GLQA 1O99A 5IJSA 4NWJA 4TN0A 1SHNA 3IDDA 5K4PA 4UOPA 4UORA 5IJQA 3ED4A 1P49A 3BDGB 4GTYA 4CYRA 4KAVA 4CXKA 2W8DA 5LRNA 4LR8A 1KHKA 1KHNA 4GTZA 5LRMA 4MHXA 4N7TA 3IGZB 2W5SA 3M7VA 4UPHA 3M8ZA 2G9YA 2W5QA 4LRDA 2GA3A 1ELXA 1KH7A 3NKRA 3UN5A 1ALHA 1E1ZP 1ELZA 2W5WA 3M8YA 4GTXA 1HQAA 1EQJA 5L0KA 2GSOA 1ZEDA 2GSUA 3T00A 1ANIA 2QZUA 4LRBA 2IFYA 4ZG9A 5EGEA 5LQQA 2X98A 5EGHA 5DLTA 1KH9A 3UN2A 1Y6VA 2VQRA 4KJGA 4KJDA 1ED8A 3Q3QA 4LR7A 1KHLA 2W5TA 3WAXA 1SHQA 1AJDA 4LRAA 3WAYA 5DLWA 2IUCB 3UN3A 3TG0A 2W5XA 3DYCA 3MK2A 5L0EA 4ZGAA 5GRRA 3BDFA 4GTWA 1AJCA 1URBA 4MY4A 1EW2A 3TX0A 4FDJA 4UPLA 3DPCA 5C66A 1ALIA 2W5RA 5L0BA 2ZKTA 1AUKA 1N2LA 5AJ9A 1E33P 4LRCA 3T02A 2ANHA 1N2KA 1ZEFA 1AJBA 4CXUA 3BDGA 4LRFA 4B56A 4YR1A 5KXAA 3B5QA 1O98A 1KHJA 4LQYA 2D1GA 3NKQA 3BDHA 1E2SP 3NKNA 3TWZA 1EW8A 1ED9A 4ZG7A 3SZYA 3T01A 3NVLA 4CYSA 4FDIA 1HDHA 3CMRA 1AJAA 3NKOA 3WAVA 1ALKA 2GSNA 3NKMA 2XRGA 5DLVA 1Y7AA 1EI6A 2W5VA 4QAXA 3NKPA 1FSUA 3WBHA
chains in the Genus database with same CATH superfamily
1EJJA 1B8JA 4UPKA 3WAWA 1ALJA 3M8WA 1KH5A 4NWXA 3SZZA 5TJ3A 3E2DA 5INHA 1ELYA 4UOOA 4ZG6A 3OT9A 1ANJA 1EW9A 1URAA 4KAYA 1ZEBA 4KM4A 3A52A 3IGYB 4LREA 2IUCA 4LR9A 5HRTA 5GOVA 1E3CP 2RH6A 4UPIA 1HJKA 5LIAA 1K7HA 2W8SA 4MIVA 3UNYA 4LR2A 4CXSA 3UO0A 1KH4A 3LXQA 2XR9A 3KD8A 3MK1A 3MK0A 2GLQA 1O99A 5IJSA 4NWJA 4TN0A 1SHNA 3IDDA 5K4PA 4UOPA 4UORA 5IJQA 3ED4A 1P49A 3BDGB 4GTYA 4CYRA 4KAVA 4CXKA 2W8DA 5LRNA 4LR8A 1KHKA 1KHNA 4GTZA 5LRMA 4MHXA 4N7TA 3IGZB 2W5SA 3M7VA 4UPHA 3M8ZA 2G9YA 2W5QA 4LRDA 2GA3A 1ELXA 1KH7A 3NKRA 3UN5A 1ALHA 1E1ZP 1ELZA 2W5WA 3M8YA 4GTXA 1HQAA 1EQJA 5L0KA 2GSOA 1ZEDA 2GSUA 3T00A 1ANIA 2QZUA 4LRBA 2IFYA 4ZG9A 5EGEA 5LQQA 2X98A 5EGHA 5DLTA 1KH9A 3UN2A 1Y6VA 2VQRA 4KJGA 4KJDA 1ED8A 3Q3QA 4LR7A 1KHLA 2W5TA 3WAXA 1SHQA 1AJDA 4LRAA 3WAYA 5DLWA 2IUCB 3UN3A 3TG0A 2W5XA 3DYCA 3MK2A 5L0EA 4ZGAA 5GRRA 3BDFA 4GTWA 1AJCA 1URBA 4MY4A 1EW2A 3TX0A 4FDJA 4UPLA 3DPCA 5C66A 1ALIA 2W5RA 5L0BA 2ZKTA 1AUKA 1N2LA 5AJ9A 1E33P 4LRCA 3T02A 2ANHA 1N2KA 1ZEFA 1AJBA 4CXUA 3BDGA 4LRFA 4B56A 4YR1A 5KXAA 3B5QA 1O98A 1KHJA 4LQYA 2D1GA 3NKQA 3BDHA 1E2SP 3NKNA 3TWZA 1EW8A 1ED9A 4ZG7A 3SZYA 3T01A 3NVLA 4CYSA 4FDIA 1HDHA 3CMRA 1AJAA 3NKOA 3WAVA 1ALKA 2GSNA 3NKMA 2XRGA 5DLVA 1Y7AA 1EI6A 2W5VA 4QAXA 3NKPA 1FSUA 3WBHA
chains in the Genus database with same CATH topology
1EJJA 1B8JA 4UPKA 3WAWA 1ALJA 3M8WA 1KH5A 4NWXA 3SZZA 5TJ3A 3E2DA 5INHA 1ELYA 4UOOA 4ZG6A 3OT9A 1ANJA 1EW9A 1URAA 4KAYA 1ZEBA 4KM4A 3A52A 3IGYB 4LREA 2IUCA 4LR9A 5HRTA 5GOVA 1E3CP 2RH6A 4UPIA 1HJKA 5LIAA 1K7HA 2W8SA 4MIVA 3UNYA 4LR2A 4CXSA 3UO0A 1KH4A 3LXQA 2XR9A 3KD8A 3MK1A 3MK0A 2GLQA 1O99A 5IJSA 4NWJA 4TN0A 1SHNA 3IDDA 5K4PA 4UOPA 4UORA 5IJQA 3ED4A 1P49A 3BDGB 4GTYA 4CYRA 4KAVA 4CXKA 2W8DA 5LRNA 4LR8A 1KHKA 1KHNA 4GTZA 5LRMA 4MHXA 4N7TA 3IGZB 2W5SA 3M7VA 4UPHA 3M8ZA 2G9YA 2W5QA 4LRDA 2GA3A 1ELXA 1KH7A 3NKRA 3UN5A 1ALHA 1E1ZP 1ELZA 2W5WA 3M8YA 4GTXA 1HQAA 1EQJA 5L0KA 2GSOA 1ZEDA 2GSUA 3T00A 1ANIA 2QZUA 4LRBA 2IFYA 4ZG9A 5EGEA 5LQQA 2X98A 5EGHA 5DLTA 1KH9A 3UN2A 1Y6VA 2VQRA 4KJGA 4KJDA 1ED8A 3Q3QA 4LR7A 1KHLA 2W5TA 3WAXA 1SHQA 1AJDA 4LRAA 3WAYA 5DLWA 2IUCB 3UN3A 3TG0A 2W5XA 3DYCA 3MK2A 5L0EA 4ZGAA 5GRRA 3BDFA 4GTWA 1AJCA 1URBA 4MY4A 1EW2A 3TX0A 4FDJA 4UPLA 3DPCA 5C66A 1ALIA 2W5RA 5L0BA 2ZKTA 1AUKA 1N2LA 5AJ9A 1E33P 4LRCA 3T02A 2ANHA 1N2KA 1ZEFA 1AJBA 4CXUA 3BDGA 4LRFA 4B56A 4YR1A 5KXAA 3B5QA 1O98A 1KHJA 4LQYA 2D1GA 3NKQA 3BDHA 1E2SP 3NKNA 3TWZA 1EW8A 1ED9A 4ZG7A 3SZYA 3T01A 3NVLA 4CYSA 4FDIA 1HDHA 3CMRA 1AJAA 3NKOA 3WAVA 1ALKA 2GSNA 3NKMA 2XRGA 5DLVA 1Y7AA 1EI6A 2W5VA 4QAXA 3NKPA 1FSUA 3WBHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EJJ A;  1B8J A;  4UPK A;  3WAW A;  1ALJ A;  3M8W A;  1KH5 A;  4NWX A;  3SZZ A;  5TJ3 A;  3E2D A;  5INH A;  1ELY A;  4UOO A;  4ZG6 A;  3OT9 A;  1ANJ A;  1EW9 A;  1URA A;  4KAY A;  1ZEB A;  4KM4 A;  3A52 A;  3IGY B;  4LRE A;  2IUC A;  4LR9 A;  5HRT A;  5GOV A;  1E3C P;  2RH6 A;  4UPI A;  1HJK A;  5LIA A;  1K7H A;  2W8S A;  4MIV A;  3UNY A;  4LR2 A;  4CXS A;  3UO0 A;  1KH4 A;  3LXQ A;  2XR9 A;  3KD8 A;  3MK1 A;  3MK0 A;  2GLQ A;  1O99 A;  5IJS A;  4NWJ A;  4TN0 A;  1SHN A;  3IDD A;  5K4P A;  4UOP A;  4UOR A;  5IJQ A;  3ED4 A;  1P49 A;  3BDG B;  4GTY A;  4CYR A;  4KAV A;  4CXK A;  2W8D A;  5LRN A;  4LR8 A;  1KHK A;  1KHN A;  4GTZ A;  5LRM A;  4MHX A;  4N7T A;  3IGZ B;  2W5S A;  3M7V A;  4UPH A;  3M8Z A;  2G9Y A;  2W5Q A;  4LRD A;  2GA3 A;  1ELX A;  1KH7 A;  3NKR A;  3UN5 A;  1ALH A;  1E1Z P;  1ELZ A;  2W5W A;  3M8Y A;  4GTX A;  1HQA A;  1EQJ A;  5L0K A;  2GSO A;  1ZED A;  2GSU A;  3T00 A;  1ANI A;  2QZU A;  4LRB A;  2IFY A;  4ZG9 A;  5EGE A;  5LQQ A;  2X98 A;  5EGH A;  5DLT A;  1KH9 A;  3UN2 A;  1Y6V A;  2VQR A;  4KJG A;  4KJD A;  1ED8 A;  3Q3Q A;  4LR7 A;  1KHL A;  2W5T A;  3WAX A;  1SHQ A;  1AJD A;  4LRA A;  3WAY A;  5DLW A;  2IUC B;  3UN3 A;  3TG0 A;  2W5X A;  3DYC A;  3MK2 A;  5L0E A;  4ZGA A;  5GRR A;  3BDF A;  4GTW A;  1AJC A;  1URB A;  4MY4 A;  1EW2 A;  3TX0 A;  4FDJ A;  4UPL A;  3DPC A;  5C66 A;  1ALI A;  2W5R A;  5L0B A;  2ZKT A;  1AUK A;  1N2L A;  5AJ9 A;  1E33 P;  4LRC A;  3T02 A;  2ANH A;  1N2K A;  1ZEF A;  1AJB A;  4CXU A;  3BDG A;  4LRF A;  4B56 A;  4YR1 A;  5KXA A;  3B5Q A;  1O98 A;  1KHJ A;  4LQY A;  2D1G A;  3NKQ A;  3BDH A;  1E2S P;  3NKN A;  3TWZ A;  1EW8 A;  1ED9 A;  4ZG7 A;  3SZY A;  3T01 A;  3NVL A;  4CYS A;  4FDI A;  1HDH A;  3CMR A;  1AJA A;  3NKO A;  3WAV A;  1ALK A;  2GSN A;  3NKM A;  2XRG A;  5DLV A;  1Y7A A;  1EI6 A;  2W5V A;  4QAX A;  3NKP A;  1FSU A;  3WBH A; 
#chains in the Genus database with same CATH topology
 1EJJ A;  1B8J A;  4UPK A;  3WAW A;  1ALJ A;  3M8W A;  1KH5 A;  4NWX A;  3SZZ A;  5TJ3 A;  3E2D A;  5INH A;  1ELY A;  4UOO A;  4ZG6 A;  3OT9 A;  1ANJ A;  1EW9 A;  1URA A;  4KAY A;  1ZEB A;  4KM4 A;  3A52 A;  3IGY B;  4LRE A;  2IUC A;  4LR9 A;  5HRT A;  5GOV A;  1E3C P;  2RH6 A;  4UPI A;  1HJK A;  5LIA A;  1K7H A;  2W8S A;  4MIV A;  3UNY A;  4LR2 A;  4CXS A;  3UO0 A;  1KH4 A;  3LXQ A;  2XR9 A;  3KD8 A;  3MK1 A;  3MK0 A;  2GLQ A;  1O99 A;  5IJS A;  4NWJ A;  4TN0 A;  1SHN A;  3IDD A;  5K4P A;  4UOP A;  4UOR A;  5IJQ A;  3ED4 A;  1P49 A;  3BDG B;  4GTY A;  4CYR A;  4KAV A;  4CXK A;  2W8D A;  5LRN A;  4LR8 A;  1KHK A;  1KHN A;  4GTZ A;  5LRM A;  4MHX A;  4N7T A;  3IGZ B;  2W5S A;  3M7V A;  4UPH A;  3M8Z A;  2G9Y A;  2W5Q A;  4LRD A;  2GA3 A;  1ELX A;  1KH7 A;  3NKR A;  3UN5 A;  1ALH A;  1E1Z P;  1ELZ A;  2W5W A;  3M8Y A;  4GTX A;  1HQA A;  1EQJ A;  5L0K A;  2GSO A;  1ZED A;  2GSU A;  3T00 A;  1ANI A;  2QZU A;  4LRB A;  2IFY A;  4ZG9 A;  5EGE A;  5LQQ A;  2X98 A;  5EGH A;  5DLT A;  1KH9 A;  3UN2 A;  1Y6V A;  2VQR A;  4KJG A;  4KJD A;  1ED8 A;  3Q3Q A;  4LR7 A;  1KHL A;  2W5T A;  3WAX A;  1SHQ A;  1AJD A;  4LRA A;  3WAY A;  5DLW A;  2IUC B;  3UN3 A;  3TG0 A;  2W5X A;  3DYC A;  3MK2 A;  5L0E A;  4ZGA A;  5GRR A;  3BDF A;  4GTW A;  1AJC A;  1URB A;  4MY4 A;  1EW2 A;  3TX0 A;  4FDJ A;  4UPL A;  3DPC A;  5C66 A;  1ALI A;  2W5R A;  5L0B A;  2ZKT A;  1AUK A;  1N2L A;  5AJ9 A;  1E33 P;  4LRC A;  3T02 A;  2ANH A;  1N2K A;  1ZEF A;  1AJB A;  4CXU A;  3BDG A;  4LRF A;  4B56 A;  4YR1 A;  5KXA A;  3B5Q A;  1O98 A;  1KHJ A;  4LQY A;  2D1G A;  3NKQ A;  3BDH A;  1E2S P;  3NKN A;  3TWZ A;  1EW8 A;  1ED9 A;  4ZG7 A;  3SZY A;  3T01 A;  3NVL A;  4CYS A;  4FDI A;  1HDH A;  3CMR A;  1AJA A;  3NKO A;  3WAV A;  1ALK A;  2GSN A;  3NKM A;  2XRG A;  5DLV A;  1Y7A A;  1EI6 A;  2W5V A;  4QAX A;  3NKP A;  1FSU A;  3WBH A; 
#chains in the Genus database with same CATH homology
 1EJJ A;  1B8J A;  4UPK A;  3WAW A;  1ALJ A;  3M8W A;  1KH5 A;  4NWX A;  3SZZ A;  5TJ3 A;  3E2D A;  5INH A;  1ELY A;  4UOO A;  4ZG6 A;  3OT9 A;  1ANJ A;  1EW9 A;  1URA A;  4KAY A;  1ZEB A;  4KM4 A;  3A52 A;  3IGY B;  4LRE A;  2IUC A;  4LR9 A;  5HRT A;  5GOV A;  1E3C P;  2RH6 A;  4UPI A;  1HJK A;  5LIA A;  1K7H A;  2W8S A;  4MIV A;  3UNY A;  4LR2 A;  4CXS A;  3UO0 A;  1KH4 A;  3LXQ A;  2XR9 A;  3KD8 A;  3MK1 A;  3MK0 A;  2GLQ A;  1O99 A;  5IJS A;  4NWJ A;  4TN0 A;  1SHN A;  3IDD A;  5K4P A;  4UOP A;  4UOR A;  5IJQ A;  3ED4 A;  1P49 A;  3BDG B;  4GTY A;  4CYR A;  4KAV A;  4CXK A;  2W8D A;  5LRN A;  4LR8 A;  1KHK A;  1KHN A;  4GTZ A;  5LRM A;  4MHX A;  4N7T A;  3IGZ B;  2W5S A;  3M7V A;  4UPH A;  3M8Z A;  2G9Y A;  2W5Q A;  4LRD A;  2GA3 A;  1ELX A;  1KH7 A;  3NKR A;  3UN5 A;  1ALH A;  1E1Z P;  1ELZ A;  2W5W A;  3M8Y A;  4GTX A;  1HQA A;  1EQJ A;  5L0K A;  2GSO A;  1ZED A;  2GSU A;  3T00 A;  1ANI A;  2QZU A;  4LRB A;  2IFY A;  4ZG9 A;  5EGE A;  5LQQ A;  2X98 A;  5EGH A;  5DLT A;  1KH9 A;  3UN2 A;  1Y6V A;  2VQR A;  4KJG A;  4KJD A;  1ED8 A;  3Q3Q A;  4LR7 A;  1KHL A;  2W5T A;  3WAX A;  1SHQ A;  1AJD A;  4LRA A;  3WAY A;  5DLW A;  2IUC B;  3UN3 A;  3TG0 A;  2W5X A;  3DYC A;  3MK2 A;  5L0E A;  4ZGA A;  5GRR A;  3BDF A;  4GTW A;  1AJC A;  1URB A;  4MY4 A;  1EW2 A;  3TX0 A;  4FDJ A;  4UPL A;  3DPC A;  5C66 A;  1ALI A;  2W5R A;  5L0B A;  2ZKT A;  1AUK A;  1N2L A;  5AJ9 A;  1E33 P;  4LRC A;  3T02 A;  2ANH A;  1N2K A;  1ZEF A;  1AJB A;  4CXU A;  3BDG A;  4LRF A;  4B56 A;  4YR1 A;  5KXA A;  3B5Q A;  1O98 A;  1KHJ A;  4LQY A;  2D1G A;  3NKQ A;  3BDH A;  1E2S P;  3NKN A;  3TWZ A;  1EW8 A;  1ED9 A;  4ZG7 A;  3SZY A;  3T01 A;  3NVL A;  4CYS A;  4FDI A;  1HDH A;  3CMR A;  1AJA A;  3NKO A;  3WAV A;  1ALK A;  2GSN A;  3NKM A;  2XRG A;  5DLV A;  1Y7A A;  1EI6 A;  2W5V A;  4QAX A;  3NKP A;  1FSU A;  3WBH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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