1Y7AA

Structure of d153h/k328w e. coli alkaline phosphatase in presence of cobalt at 1.77 a resolution
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDWQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 162
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y7aA00
1ELZA 5HRTA 4KM4A 4NWXA 4LR7A 3NKOA 4GTWA 5LRNA 2GA3A 4NWJA 1O98A 3NKQA 1ED9A 1E33P 4CXKA 3E2DA 1Y7AA 1KH9A 5L0EA 1KHJA 3SZZA 3UO0A 3WAYA 3WAXA 4CYRA 3DPCA 4MIVA 3IGZB 3UN5A 1ALJA 2GSNA 5DLTA 3SZYA 1ALKA 4LREA 1EW9A 5LRMA 5KXAA 1AJDA 2GSOA 2QZUA 3UNYA 5DLVA 5LIAA 5LQQA 3NKNA 4LRAA 3BDGB 2ANHA 1ZEDA 2XR9A 3TG0A 3IGYB 4TN0A 1EW8A 5GRRA 1FSUA 1HDHA 1HQAA 1SHNA 1ZEBA 2VQRA 3TX0A 2IFYA 1K7HA 1AJCA 3NKRA 2W5XA 2W5QA 3MK0A 1EI6A 1URAA 4GTZA 1ELYA 1AJAA 4LR8A 1ANJA 4FDIA 2XRGA 4GTXA 4ZGAA 1E2SP 4KJGA 1AJBA 3M8ZA 4LRFA 2IUCA 4LR9A 3ED4A 3LXQA 4UPKA 5EGEA 5DLWA 3M7VA 1N2LA 4UOOA 3WBHA 3NKPA 2W5TA 5L0BA 4UPIA 4UOPA 3WAWA 5INHA 5AJ9A 4UPHA 1KHNA 2IUCB 3IDDA 3T01A 4ZG6A 3Q3QA 3MK2A 4MY4A 3NKMA 3BDHA 4FDJA 1EJJA 1EQJA 3KD8A 3OT9A 3WAVA 2ZKTA 1KHKA 1ALIA 3T02A 5IJSA 1SHQA 3UN3A 2G9YA 1Y6VA 4KAVA 2W5VA 3UN2A 4CXSA 1B8JA 1E1ZP 4UORA 2W8DA 1ED8A 1URBA 1ZEFA 2W8SA 3T00A 4LQYA 1ANIA 2X98A 4LRCA 5EGHA 4LR2A 1N2KA 3TWZA 3M8YA 1KHLA 1KH4A 2RH6A 1KH7A 3M8WA 4YR1A 2W5RA 5K4PA 4UPLA 4ZG9A 1HJKA 3DYCA 5TJ3A 1AUKA 2GLQA 4GTYA 3B5QA 4MHXA 3A52A 3MK1A 4ZG7A 1E3CP 4CXUA 5L0KA 2W5WA 4LRBA 2W5SA 3NVLA 4KAYA 5C66A 4KJDA 3BDFA 3BDGA 4CYSA 4N7TA 4QAXA 1ELXA 4LRDA 5GOVA 4B56A 1ALHA 3CMRA 5IJQA 1O99A 1KH5A 1P49A 1EW2A 2GSUA 2D1GA
chains in the Genus database with same CATH superfamily
1ELZA 5HRTA 4KM4A 4NWXA 4LR7A 3NKOA 4GTWA 5LRNA 2GA3A 4NWJA 1O98A 3NKQA 1ED9A 1E33P 4CXKA 3E2DA 1Y7AA 1KH9A 5L0EA 1KHJA 3SZZA 3UO0A 3WAYA 3WAXA 4CYRA 3DPCA 4MIVA 3IGZB 3UN5A 1ALJA 2GSNA 5DLTA 3SZYA 1ALKA 4LREA 1EW9A 5LRMA 5KXAA 1AJDA 2GSOA 2QZUA 3UNYA 5DLVA 5LIAA 5LQQA 3NKNA 4LRAA 3BDGB 2ANHA 1ZEDA 2XR9A 3TG0A 3IGYB 4TN0A 1EW8A 5GRRA 1FSUA 1HDHA 1HQAA 1SHNA 1ZEBA 2VQRA 3TX0A 2IFYA 1K7HA 1AJCA 3NKRA 2W5XA 2W5QA 3MK0A 1EI6A 1URAA 4GTZA 1ELYA 1AJAA 4LR8A 1ANJA 4FDIA 2XRGA 4GTXA 4ZGAA 1E2SP 4KJGA 1AJBA 3M8ZA 4LRFA 2IUCA 4LR9A 3ED4A 3LXQA 4UPKA 5EGEA 5DLWA 3M7VA 1N2LA 4UOOA 3WBHA 3NKPA 2W5TA 5L0BA 4UPIA 4UOPA 3WAWA 5INHA 5AJ9A 4UPHA 1KHNA 2IUCB 3IDDA 3T01A 4ZG6A 3Q3QA 3MK2A 4MY4A 3NKMA 3BDHA 4FDJA 1EJJA 1EQJA 3KD8A 3OT9A 3WAVA 2ZKTA 1KHKA 1ALIA 3T02A 5IJSA 1SHQA 3UN3A 2G9YA 1Y6VA 4KAVA 2W5VA 3UN2A 4CXSA 1B8JA 1E1ZP 4UORA 2W8DA 1ED8A 1URBA 1ZEFA 2W8SA 3T00A 4LQYA 1ANIA 2X98A 4LRCA 5EGHA 4LR2A 1N2KA 3TWZA 3M8YA 1KHLA 1KH4A 2RH6A 1KH7A 3M8WA 4YR1A 2W5RA 5K4PA 4UPLA 4ZG9A 1HJKA 3DYCA 5TJ3A 1AUKA 2GLQA 4GTYA 3B5QA 4MHXA 3A52A 3MK1A 4ZG7A 1E3CP 4CXUA 5L0KA 2W5WA 4LRBA 2W5SA 3NVLA 4KAYA 5C66A 4KJDA 3BDFA 3BDGA 4CYSA 4N7TA 4QAXA 1ELXA 4LRDA 5GOVA 4B56A 1ALHA 3CMRA 5IJQA 1O99A 1KH5A 1P49A 1EW2A 2GSUA 2D1GA
chains in the Genus database with same CATH topology
1ELZA 5HRTA 4KM4A 4NWXA 4LR7A 3NKOA 4GTWA 5LRNA 2GA3A 4NWJA 1O98A 3NKQA 1ED9A 1E33P 4CXKA 3E2DA 1Y7AA 1KH9A 5L0EA 1KHJA 3SZZA 3UO0A 3WAYA 3WAXA 4CYRA 3DPCA 4MIVA 3IGZB 3UN5A 1ALJA 2GSNA 5DLTA 3SZYA 1ALKA 4LREA 1EW9A 5LRMA 5KXAA 1AJDA 2GSOA 2QZUA 3UNYA 5DLVA 5LIAA 5LQQA 3NKNA 4LRAA 3BDGB 2ANHA 1ZEDA 2XR9A 3TG0A 3IGYB 4TN0A 1EW8A 5GRRA 1FSUA 1HDHA 1HQAA 1SHNA 1ZEBA 2VQRA 3TX0A 2IFYA 1K7HA 1AJCA 3NKRA 2W5XA 2W5QA 3MK0A 1EI6A 1URAA 4GTZA 1ELYA 1AJAA 4LR8A 1ANJA 4FDIA 2XRGA 4GTXA 4ZGAA 1E2SP 4KJGA 1AJBA 3M8ZA 4LRFA 2IUCA 4LR9A 3ED4A 3LXQA 4UPKA 5EGEA 5DLWA 3M7VA 1N2LA 4UOOA 3WBHA 3NKPA 2W5TA 5L0BA 4UPIA 4UOPA 3WAWA 5INHA 5AJ9A 4UPHA 1KHNA 2IUCB 3IDDA 3T01A 4ZG6A 3Q3QA 3MK2A 4MY4A 3NKMA 3BDHA 4FDJA 1EJJA 1EQJA 3KD8A 3OT9A 3WAVA 2ZKTA 1KHKA 1ALIA 3T02A 5IJSA 1SHQA 3UN3A 2G9YA 1Y6VA 4KAVA 2W5VA 3UN2A 4CXSA 1B8JA 1E1ZP 4UORA 2W8DA 1ED8A 1URBA 1ZEFA 2W8SA 3T00A 4LQYA 1ANIA 2X98A 4LRCA 5EGHA 4LR2A 1N2KA 3TWZA 3M8YA 1KHLA 1KH4A 2RH6A 1KH7A 3M8WA 4YR1A 2W5RA 5K4PA 4UPLA 4ZG9A 1HJKA 3DYCA 5TJ3A 1AUKA 2GLQA 4GTYA 3B5QA 4MHXA 3A52A 3MK1A 4ZG7A 1E3CP 4CXUA 5L0KA 2W5WA 4LRBA 2W5SA 3NVLA 4KAYA 5C66A 4KJDA 3BDFA 3BDGA 4CYSA 4N7TA 4QAXA 1ELXA 4LRDA 5GOVA 4B56A 1ALHA 3CMRA 5IJQA 1O99A 1KH5A 1P49A 1EW2A 2GSUA 2D1GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ELZ A;  5HRT A;  4KM4 A;  4NWX A;  4LR7 A;  3NKO A;  4GTW A;  5LRN A;  2GA3 A;  4NWJ A;  1O98 A;  3NKQ A;  1ED9 A;  1E33 P;  4CXK A;  3E2D A;  1Y7A A;  1KH9 A;  5L0E A;  1KHJ A;  3SZZ A;  3UO0 A;  3WAY A;  3WAX A;  4CYR A;  3DPC A;  4MIV A;  3IGZ B;  3UN5 A;  1ALJ A;  2GSN A;  5DLT A;  3SZY A;  1ALK A;  4LRE A;  1EW9 A;  5LRM A;  5KXA A;  1AJD A;  2GSO A;  2QZU A;  3UNY A;  5DLV A;  5LIA A;  5LQQ A;  3NKN A;  4LRA A;  3BDG B;  2ANH A;  1ZED A;  2XR9 A;  3TG0 A;  3IGY B;  4TN0 A;  1EW8 A;  5GRR A;  1FSU A;  1HDH A;  1HQA A;  1SHN A;  1ZEB A;  2VQR A;  3TX0 A;  2IFY A;  1K7H A;  1AJC A;  3NKR A;  2W5X A;  2W5Q A;  3MK0 A;  1EI6 A;  1URA A;  4GTZ A;  1ELY A;  1AJA A;  4LR8 A;  1ANJ A;  4FDI A;  2XRG A;  4GTX A;  4ZGA A;  1E2S P;  4KJG A;  1AJB A;  3M8Z A;  4LRF A;  2IUC A;  4LR9 A;  3ED4 A;  3LXQ A;  4UPK A;  5EGE A;  5DLW A;  3M7V A;  1N2L A;  4UOO A;  3WBH A;  3NKP A;  2W5T A;  5L0B A;  4UPI A;  4UOP A;  3WAW A;  5INH A;  5AJ9 A;  4UPH A;  1KHN A;  2IUC B;  3IDD A;  3T01 A;  4ZG6 A;  3Q3Q A;  3MK2 A;  4MY4 A;  3NKM A;  3BDH A;  4FDJ A;  1EJJ A;  1EQJ A;  3KD8 A;  3OT9 A;  3WAV A;  2ZKT A;  1KHK A;  1ALI A;  3T02 A;  5IJS A;  1SHQ A;  3UN3 A;  2G9Y A;  1Y6V A;  4KAV A;  2W5V A;  3UN2 A;  4CXS A;  1B8J A;  1E1Z P;  4UOR A;  2W8D A;  1ED8 A;  1URB A;  1ZEF A;  2W8S A;  3T00 A;  4LQY A;  1ANI A;  2X98 A;  4LRC A;  5EGH A;  4LR2 A;  1N2K A;  3TWZ A;  3M8Y A;  1KHL A;  1KH4 A;  2RH6 A;  1KH7 A;  3M8W A;  4YR1 A;  2W5R A;  5K4P A;  4UPL A;  4ZG9 A;  1HJK A;  3DYC A;  5TJ3 A;  1AUK A;  2GLQ A;  4GTY A;  3B5Q A;  4MHX A;  3A52 A;  3MK1 A;  4ZG7 A;  1E3C P;  4CXU A;  5L0K A;  2W5W A;  4LRB A;  2W5S A;  3NVL A;  4KAY A;  5C66 A;  4KJD A;  3BDF A;  3BDG A;  4CYS A;  4N7T A;  4QAX A;  1ELX A;  4LRD A;  5GOV A;  4B56 A;  1ALH A;  3CMR A;  5IJQ A;  1O99 A;  1KH5 A;  1P49 A;  1EW2 A;  2GSU A;  2D1G A; 
#chains in the Genus database with same CATH topology
 1ELZ A;  5HRT A;  4KM4 A;  4NWX A;  4LR7 A;  3NKO A;  4GTW A;  5LRN A;  2GA3 A;  4NWJ A;  1O98 A;  3NKQ A;  1ED9 A;  1E33 P;  4CXK A;  3E2D A;  1Y7A A;  1KH9 A;  5L0E A;  1KHJ A;  3SZZ A;  3UO0 A;  3WAY A;  3WAX A;  4CYR A;  3DPC A;  4MIV A;  3IGZ B;  3UN5 A;  1ALJ A;  2GSN A;  5DLT A;  3SZY A;  1ALK A;  4LRE A;  1EW9 A;  5LRM A;  5KXA A;  1AJD A;  2GSO A;  2QZU A;  3UNY A;  5DLV A;  5LIA A;  5LQQ A;  3NKN A;  4LRA A;  3BDG B;  2ANH A;  1ZED A;  2XR9 A;  3TG0 A;  3IGY B;  4TN0 A;  1EW8 A;  5GRR A;  1FSU A;  1HDH A;  1HQA A;  1SHN A;  1ZEB A;  2VQR A;  3TX0 A;  2IFY A;  1K7H A;  1AJC A;  3NKR A;  2W5X A;  2W5Q A;  3MK0 A;  1EI6 A;  1URA A;  4GTZ A;  1ELY A;  1AJA A;  4LR8 A;  1ANJ A;  4FDI A;  2XRG A;  4GTX A;  4ZGA A;  1E2S P;  4KJG A;  1AJB A;  3M8Z A;  4LRF A;  2IUC A;  4LR9 A;  3ED4 A;  3LXQ A;  4UPK A;  5EGE A;  5DLW A;  3M7V A;  1N2L A;  4UOO A;  3WBH A;  3NKP A;  2W5T A;  5L0B A;  4UPI A;  4UOP A;  3WAW A;  5INH A;  5AJ9 A;  4UPH A;  1KHN A;  2IUC B;  3IDD A;  3T01 A;  4ZG6 A;  3Q3Q A;  3MK2 A;  4MY4 A;  3NKM A;  3BDH A;  4FDJ A;  1EJJ A;  1EQJ A;  3KD8 A;  3OT9 A;  3WAV A;  2ZKT A;  1KHK A;  1ALI A;  3T02 A;  5IJS A;  1SHQ A;  3UN3 A;  2G9Y A;  1Y6V A;  4KAV A;  2W5V A;  3UN2 A;  4CXS A;  1B8J A;  1E1Z P;  4UOR A;  2W8D A;  1ED8 A;  1URB A;  1ZEF A;  2W8S A;  3T00 A;  4LQY A;  1ANI A;  2X98 A;  4LRC A;  5EGH A;  4LR2 A;  1N2K A;  3TWZ A;  3M8Y A;  1KHL A;  1KH4 A;  2RH6 A;  1KH7 A;  3M8W A;  4YR1 A;  2W5R A;  5K4P A;  4UPL A;  4ZG9 A;  1HJK A;  3DYC A;  5TJ3 A;  1AUK A;  2GLQ A;  4GTY A;  3B5Q A;  4MHX A;  3A52 A;  3MK1 A;  4ZG7 A;  1E3C P;  4CXU A;  5L0K A;  2W5W A;  4LRB A;  2W5S A;  3NVL A;  4KAY A;  5C66 A;  4KJD A;  3BDF A;  3BDG A;  4CYS A;  4N7T A;  4QAX A;  1ELX A;  4LRD A;  5GOV A;  4B56 A;  1ALH A;  3CMR A;  5IJQ A;  1O99 A;  1KH5 A;  1P49 A;  1EW2 A;  2GSU A;  2D1G A; 
#chains in the Genus database with same CATH homology
 1ELZ A;  5HRT A;  4KM4 A;  4NWX A;  4LR7 A;  3NKO A;  4GTW A;  5LRN A;  2GA3 A;  4NWJ A;  1O98 A;  3NKQ A;  1ED9 A;  1E33 P;  4CXK A;  3E2D A;  1Y7A A;  1KH9 A;  5L0E A;  1KHJ A;  3SZZ A;  3UO0 A;  3WAY A;  3WAX A;  4CYR A;  3DPC A;  4MIV A;  3IGZ B;  3UN5 A;  1ALJ A;  2GSN A;  5DLT A;  3SZY A;  1ALK A;  4LRE A;  1EW9 A;  5LRM A;  5KXA A;  1AJD A;  2GSO A;  2QZU A;  3UNY A;  5DLV A;  5LIA A;  5LQQ A;  3NKN A;  4LRA A;  3BDG B;  2ANH A;  1ZED A;  2XR9 A;  3TG0 A;  3IGY B;  4TN0 A;  1EW8 A;  5GRR A;  1FSU A;  1HDH A;  1HQA A;  1SHN A;  1ZEB A;  2VQR A;  3TX0 A;  2IFY A;  1K7H A;  1AJC A;  3NKR A;  2W5X A;  2W5Q A;  3MK0 A;  1EI6 A;  1URA A;  4GTZ A;  1ELY A;  1AJA A;  4LR8 A;  1ANJ A;  4FDI A;  2XRG A;  4GTX A;  4ZGA A;  1E2S P;  4KJG A;  1AJB A;  3M8Z A;  4LRF A;  2IUC A;  4LR9 A;  3ED4 A;  3LXQ A;  4UPK A;  5EGE A;  5DLW A;  3M7V A;  1N2L A;  4UOO A;  3WBH A;  3NKP A;  2W5T A;  5L0B A;  4UPI A;  4UOP A;  3WAW A;  5INH A;  5AJ9 A;  4UPH A;  1KHN A;  2IUC B;  3IDD A;  3T01 A;  4ZG6 A;  3Q3Q A;  3MK2 A;  4MY4 A;  3NKM A;  3BDH A;  4FDJ A;  1EJJ A;  1EQJ A;  3KD8 A;  3OT9 A;  3WAV A;  2ZKT A;  1KHK A;  1ALI A;  3T02 A;  5IJS A;  1SHQ A;  3UN3 A;  2G9Y A;  1Y6V A;  4KAV A;  2W5V A;  3UN2 A;  4CXS A;  1B8J A;  1E1Z P;  4UOR A;  2W8D A;  1ED8 A;  1URB A;  1ZEF A;  2W8S A;  3T00 A;  4LQY A;  1ANI A;  2X98 A;  4LRC A;  5EGH A;  4LR2 A;  1N2K A;  3TWZ A;  3M8Y A;  1KHL A;  1KH4 A;  2RH6 A;  1KH7 A;  3M8W A;  4YR1 A;  2W5R A;  5K4P A;  4UPL A;  4ZG9 A;  1HJK A;  3DYC A;  5TJ3 A;  1AUK A;  2GLQ A;  4GTY A;  3B5Q A;  4MHX A;  3A52 A;  3MK1 A;  4ZG7 A;  1E3C P;  4CXU A;  5L0K A;  2W5W A;  4LRB A;  2W5S A;  3NVL A;  4KAY A;  5C66 A;  4KJD A;  3BDF A;  3BDG A;  4CYS A;  4N7T A;  4QAX A;  1ELX A;  4LRD A;  5GOV A;  4B56 A;  1ALH A;  3CMR A;  5IJQ A;  1O99 A;  1KH5 A;  1P49 A;  1EW2 A;  2GSU A;  2D1G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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