4YR1A

Crystal structure of e. coli alkaline phosphatase d101a/d153a in complex with inorganic phosphate
Total Genus 155
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
443
structure length
443
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTASAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQAATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLKSA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Hydrolase
total genus 155
structure length 443
sequence length 443
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4yr1A00
1ALKA 1ALJA 3TG0A 1ALHA 1ZEBA 2D1GA 1N2KA 4ZGAA 2XRGA 5LRNA 5GRRA 2GSUA 5DLTA 2W5TA 1P49A 3TX0A 5K4PA 2QZUA 3M8WA 3CMRA 3T02A 1ANIA 2W5RA 1HJKA 5GOVA 3BDGB 5HRTA 5IJQA 5LQQA 3NVLA 1SHNA 4MIVA 3A52A 3TWZA 3UNYA 4LR2A 1O99A 4ZG9A 4GTZA 5IJSA 5EGEA 3B5QA 5DLWA 4LRDA 1KHJA 3MK0A 4KAVA 4CXUA 2IUCB 1KH4A 1ANJA 1Y6VA 2ANHA 2X98A 4LREA 1KH5A 3NKQA 1HQAA 4MHXA 1ED9A 5L0KA 3UO0A 3NKOA 1KHKA 5AJ9A 3UN3A 3WAWA 4GTYA 1E1ZP 1Y7AA 5C66A 1N2LA 4CXKA 3DYCA 3WAVA 1KH7A 1B8JA 1ELXA 1URAA 2GSNA 3LXQA 3MK1A 1E3CP 1ELZA 4YR1A 5INHA 4KAYA 2IUCA 3Q3QA 1FSUA 3M8ZA 4QAXA 3IGYB 3SZYA 3WBHA 4N7TA 3NKNA 5TJ3A 1KHNA 1AJBA 3ED4A 3M7VA 4ZG7A 4UOOA 2G9YA 4FDJA 3IDDA 4UORA 2XR9A 4GTXA 1EQJA 1E33P 1ED8A 4CXSA 2RH6A 4LR7A 2W8DA 4LRBA 3BDHA 4FDIA 5LIAA 2W5VA 1K7HA 1E2SP 1ZEDA 2W5XA 4MY4A 4UPKA 3BDGA 1ALIA 4KM4A 4LRCA 4CYSA 4GTWA 1EW8A 1EW9A 2VQRA 3M8YA 3NKPA 1ELYA 1AJDA 4LRFA 1EJJA 1SHQA 4LR8A 4B56A 5DLVA 5LRMA 3WAYA 3OT9A 1HDHA 1AJAA 2W5WA 2IFYA 3SZZA 4CYRA 4KJDA 4ZG6A 3UN5A 3WAXA 1KH9A 2ZKTA 3T01A 4UPLA 3BDFA 4LQYA 3KD8A 5L0EA 3E2DA 3MK2A 3NKRA 4UPIA 2W5QA 4LR9A 3T00A 2GA3A 4UOPA 1KHLA 3UN2A 5EGHA 5L0BA 2GSOA 4LRAA 3NKMA 4NWXA 1AJCA 4TN0A 4KJGA 2W8SA 4NWJA 5KXAA 1EW2A 1O98A 3IGZB 1URBA 2W5SA 1AUKA 1EI6A 3DPCA 2GLQA 1ZEFA 4UPHA
chains in the Genus database with same CATH superfamily
1ALKA 1ALJA 3TG0A 1ALHA 1ZEBA 2D1GA 1N2KA 4ZGAA 2XRGA 5LRNA 5GRRA 2GSUA 5DLTA 2W5TA 1P49A 3TX0A 5K4PA 2QZUA 3M8WA 3CMRA 3T02A 1ANIA 2W5RA 1HJKA 5GOVA 3BDGB 5HRTA 5IJQA 5LQQA 3NVLA 1SHNA 4MIVA 3A52A 3TWZA 3UNYA 4LR2A 1O99A 4ZG9A 4GTZA 5IJSA 5EGEA 3B5QA 5DLWA 4LRDA 1KHJA 3MK0A 4KAVA 4CXUA 2IUCB 1KH4A 1ANJA 1Y6VA 2ANHA 2X98A 4LREA 1KH5A 3NKQA 1HQAA 4MHXA 1ED9A 5L0KA 3UO0A 3NKOA 1KHKA 5AJ9A 3UN3A 3WAWA 4GTYA 1E1ZP 1Y7AA 5C66A 1N2LA 4CXKA 3DYCA 3WAVA 1KH7A 1B8JA 1ELXA 1URAA 2GSNA 3LXQA 3MK1A 1E3CP 1ELZA 4YR1A 5INHA 4KAYA 2IUCA 3Q3QA 1FSUA 3M8ZA 4QAXA 3IGYB 3SZYA 3WBHA 4N7TA 3NKNA 5TJ3A 1KHNA 1AJBA 3ED4A 3M7VA 4ZG7A 4UOOA 2G9YA 4FDJA 3IDDA 4UORA 2XR9A 4GTXA 1EQJA 1E33P 1ED8A 4CXSA 2RH6A 4LR7A 2W8DA 4LRBA 3BDHA 4FDIA 5LIAA 2W5VA 1K7HA 1E2SP 1ZEDA 2W5XA 4MY4A 4UPKA 3BDGA 1ALIA 4KM4A 4LRCA 4CYSA 4GTWA 1EW8A 1EW9A 2VQRA 3M8YA 3NKPA 1ELYA 1AJDA 4LRFA 1EJJA 1SHQA 4LR8A 4B56A 5DLVA 5LRMA 3WAYA 3OT9A 1HDHA 1AJAA 2W5WA 2IFYA 3SZZA 4CYRA 4KJDA 4ZG6A 3UN5A 3WAXA 1KH9A 2ZKTA 3T01A 4UPLA 3BDFA 4LQYA 3KD8A 5L0EA 3E2DA 3MK2A 3NKRA 4UPIA 2W5QA 4LR9A 3T00A 2GA3A 4UOPA 1KHLA 3UN2A 5EGHA 5L0BA 2GSOA 4LRAA 3NKMA 4NWXA 1AJCA 4TN0A 4KJGA 2W8SA 4NWJA 5KXAA 1EW2A 1O98A 3IGZB 1URBA 2W5SA 1AUKA 1EI6A 3DPCA 2GLQA 1ZEFA 4UPHA
chains in the Genus database with same CATH topology
1ALKA 1ALJA 3TG0A 1ALHA 1ZEBA 2D1GA 1N2KA 4ZGAA 2XRGA 5LRNA 5GRRA 2GSUA 5DLTA 2W5TA 1P49A 3TX0A 5K4PA 2QZUA 3M8WA 3CMRA 3T02A 1ANIA 2W5RA 1HJKA 5GOVA 3BDGB 5HRTA 5IJQA 5LQQA 3NVLA 1SHNA 4MIVA 3A52A 3TWZA 3UNYA 4LR2A 1O99A 4ZG9A 4GTZA 5IJSA 5EGEA 3B5QA 5DLWA 4LRDA 1KHJA 3MK0A 4KAVA 4CXUA 2IUCB 1KH4A 1ANJA 1Y6VA 2ANHA 2X98A 4LREA 1KH5A 3NKQA 1HQAA 4MHXA 1ED9A 5L0KA 3UO0A 3NKOA 1KHKA 5AJ9A 3UN3A 3WAWA 4GTYA 1E1ZP 1Y7AA 5C66A 1N2LA 4CXKA 3DYCA 3WAVA 1KH7A 1B8JA 1ELXA 1URAA 2GSNA 3LXQA 3MK1A 1E3CP 1ELZA 4YR1A 5INHA 4KAYA 2IUCA 3Q3QA 1FSUA 3M8ZA 4QAXA 3IGYB 3SZYA 3WBHA 4N7TA 3NKNA 5TJ3A 1KHNA 1AJBA 3ED4A 3M7VA 4ZG7A 4UOOA 2G9YA 4FDJA 3IDDA 4UORA 2XR9A 4GTXA 1EQJA 1E33P 1ED8A 4CXSA 2RH6A 4LR7A 2W8DA 4LRBA 3BDHA 4FDIA 5LIAA 2W5VA 1K7HA 1E2SP 1ZEDA 2W5XA 4MY4A 4UPKA 3BDGA 1ALIA 4KM4A 4LRCA 4CYSA 4GTWA 1EW8A 1EW9A 2VQRA 3M8YA 3NKPA 1ELYA 1AJDA 4LRFA 1EJJA 1SHQA 4LR8A 4B56A 5DLVA 5LRMA 3WAYA 3OT9A 1HDHA 1AJAA 2W5WA 2IFYA 3SZZA 4CYRA 4KJDA 4ZG6A 3UN5A 3WAXA 1KH9A 2ZKTA 3T01A 4UPLA 3BDFA 4LQYA 3KD8A 5L0EA 3E2DA 3MK2A 3NKRA 4UPIA 2W5QA 4LR9A 3T00A 2GA3A 4UOPA 1KHLA 3UN2A 5EGHA 5L0BA 2GSOA 4LRAA 3NKMA 4NWXA 1AJCA 4TN0A 4KJGA 2W8SA 4NWJA 5KXAA 1EW2A 1O98A 3IGZB 1URBA 2W5SA 1AUKA 1EI6A 3DPCA 2GLQA 1ZEFA 4UPHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ALK A;  1ALJ A;  3TG0 A;  1ALH A;  1ZEB A;  2D1G A;  1N2K A;  4ZGA A;  2XRG A;  5LRN A;  5GRR A;  2GSU A;  5DLT A;  2W5T A;  1P49 A;  3TX0 A;  5K4P A;  2QZU A;  3M8W A;  3CMR A;  3T02 A;  1ANI A;  2W5R A;  1HJK A;  5GOV A;  3BDG B;  5HRT A;  5IJQ A;  5LQQ A;  3NVL A;  1SHN A;  4MIV A;  3A52 A;  3TWZ A;  3UNY A;  4LR2 A;  1O99 A;  4ZG9 A;  4GTZ A;  5IJS A;  5EGE A;  3B5Q A;  5DLW A;  4LRD A;  1KHJ A;  3MK0 A;  4KAV A;  4CXU A;  2IUC B;  1KH4 A;  1ANJ A;  1Y6V A;  2ANH A;  2X98 A;  4LRE A;  1KH5 A;  3NKQ A;  1HQA A;  4MHX A;  1ED9 A;  5L0K A;  3UO0 A;  3NKO A;  1KHK A;  5AJ9 A;  3UN3 A;  3WAW A;  4GTY A;  1E1Z P;  1Y7A A;  5C66 A;  1N2L A;  4CXK A;  3DYC A;  3WAV A;  1KH7 A;  1B8J A;  1ELX A;  1URA A;  2GSN A;  3LXQ A;  3MK1 A;  1E3C P;  1ELZ A;  4YR1 A;  5INH A;  4KAY A;  2IUC A;  3Q3Q A;  1FSU A;  3M8Z A;  4QAX A;  3IGY B;  3SZY A;  3WBH A;  4N7T A;  3NKN A;  5TJ3 A;  1KHN A;  1AJB A;  3ED4 A;  3M7V A;  4ZG7 A;  4UOO A;  2G9Y A;  4FDJ A;  3IDD A;  4UOR A;  2XR9 A;  4GTX A;  1EQJ A;  1E33 P;  1ED8 A;  4CXS A;  2RH6 A;  4LR7 A;  2W8D A;  4LRB A;  3BDH A;  4FDI A;  5LIA A;  2W5V A;  1K7H A;  1E2S P;  1ZED A;  2W5X A;  4MY4 A;  4UPK A;  3BDG A;  1ALI A;  4KM4 A;  4LRC A;  4CYS A;  4GTW A;  1EW8 A;  1EW9 A;  2VQR A;  3M8Y A;  3NKP A;  1ELY A;  1AJD A;  4LRF A;  1EJJ A;  1SHQ A;  4LR8 A;  4B56 A;  5DLV A;  5LRM A;  3WAY A;  3OT9 A;  1HDH A;  1AJA A;  2W5W A;  2IFY A;  3SZZ A;  4CYR A;  4KJD A;  4ZG6 A;  3UN5 A;  3WAX A;  1KH9 A;  2ZKT A;  3T01 A;  4UPL A;  3BDF A;  4LQY A;  3KD8 A;  5L0E A;  3E2D A;  3MK2 A;  3NKR A;  4UPI A;  2W5Q A;  4LR9 A;  3T00 A;  2GA3 A;  4UOP A;  1KHL A;  3UN2 A;  5EGH A;  5L0B A;  2GSO A;  4LRA A;  3NKM A;  4NWX A;  1AJC A;  4TN0 A;  4KJG A;  2W8S A;  4NWJ A;  5KXA A;  1EW2 A;  1O98 A;  3IGZ B;  1URB A;  2W5S A;  1AUK A;  1EI6 A;  3DPC A;  2GLQ A;  1ZEF A;  4UPH A; 
#chains in the Genus database with same CATH topology
 1ALK A;  1ALJ A;  3TG0 A;  1ALH A;  1ZEB A;  2D1G A;  1N2K A;  4ZGA A;  2XRG A;  5LRN A;  5GRR A;  2GSU A;  5DLT A;  2W5T A;  1P49 A;  3TX0 A;  5K4P A;  2QZU A;  3M8W A;  3CMR A;  3T02 A;  1ANI A;  2W5R A;  1HJK A;  5GOV A;  3BDG B;  5HRT A;  5IJQ A;  5LQQ A;  3NVL A;  1SHN A;  4MIV A;  3A52 A;  3TWZ A;  3UNY A;  4LR2 A;  1O99 A;  4ZG9 A;  4GTZ A;  5IJS A;  5EGE A;  3B5Q A;  5DLW A;  4LRD A;  1KHJ A;  3MK0 A;  4KAV A;  4CXU A;  2IUC B;  1KH4 A;  1ANJ A;  1Y6V A;  2ANH A;  2X98 A;  4LRE A;  1KH5 A;  3NKQ A;  1HQA A;  4MHX A;  1ED9 A;  5L0K A;  3UO0 A;  3NKO A;  1KHK A;  5AJ9 A;  3UN3 A;  3WAW A;  4GTY A;  1E1Z P;  1Y7A A;  5C66 A;  1N2L A;  4CXK A;  3DYC A;  3WAV A;  1KH7 A;  1B8J A;  1ELX A;  1URA A;  2GSN A;  3LXQ A;  3MK1 A;  1E3C P;  1ELZ A;  4YR1 A;  5INH A;  4KAY A;  2IUC A;  3Q3Q A;  1FSU A;  3M8Z A;  4QAX A;  3IGY B;  3SZY A;  3WBH A;  4N7T A;  3NKN A;  5TJ3 A;  1KHN A;  1AJB A;  3ED4 A;  3M7V A;  4ZG7 A;  4UOO A;  2G9Y A;  4FDJ A;  3IDD A;  4UOR A;  2XR9 A;  4GTX A;  1EQJ A;  1E33 P;  1ED8 A;  4CXS A;  2RH6 A;  4LR7 A;  2W8D A;  4LRB A;  3BDH A;  4FDI A;  5LIA A;  2W5V A;  1K7H A;  1E2S P;  1ZED A;  2W5X A;  4MY4 A;  4UPK A;  3BDG A;  1ALI A;  4KM4 A;  4LRC A;  4CYS A;  4GTW A;  1EW8 A;  1EW9 A;  2VQR A;  3M8Y A;  3NKP A;  1ELY A;  1AJD A;  4LRF A;  1EJJ A;  1SHQ A;  4LR8 A;  4B56 A;  5DLV A;  5LRM A;  3WAY A;  3OT9 A;  1HDH A;  1AJA A;  2W5W A;  2IFY A;  3SZZ A;  4CYR A;  4KJD A;  4ZG6 A;  3UN5 A;  3WAX A;  1KH9 A;  2ZKT A;  3T01 A;  4UPL A;  3BDF A;  4LQY A;  3KD8 A;  5L0E A;  3E2D A;  3MK2 A;  3NKR A;  4UPI A;  2W5Q A;  4LR9 A;  3T00 A;  2GA3 A;  4UOP A;  1KHL A;  3UN2 A;  5EGH A;  5L0B A;  2GSO A;  4LRA A;  3NKM A;  4NWX A;  1AJC A;  4TN0 A;  4KJG A;  2W8S A;  4NWJ A;  5KXA A;  1EW2 A;  1O98 A;  3IGZ B;  1URB A;  2W5S A;  1AUK A;  1EI6 A;  3DPC A;  2GLQ A;  1ZEF A;  4UPH A; 
#chains in the Genus database with same CATH homology
 1ALK A;  1ALJ A;  3TG0 A;  1ALH A;  1ZEB A;  2D1G A;  1N2K A;  4ZGA A;  2XRG A;  5LRN A;  5GRR A;  2GSU A;  5DLT A;  2W5T A;  1P49 A;  3TX0 A;  5K4P A;  2QZU A;  3M8W A;  3CMR A;  3T02 A;  1ANI A;  2W5R A;  1HJK A;  5GOV A;  3BDG B;  5HRT A;  5IJQ A;  5LQQ A;  3NVL A;  1SHN A;  4MIV A;  3A52 A;  3TWZ A;  3UNY A;  4LR2 A;  1O99 A;  4ZG9 A;  4GTZ A;  5IJS A;  5EGE A;  3B5Q A;  5DLW A;  4LRD A;  1KHJ A;  3MK0 A;  4KAV A;  4CXU A;  2IUC B;  1KH4 A;  1ANJ A;  1Y6V A;  2ANH A;  2X98 A;  4LRE A;  1KH5 A;  3NKQ A;  1HQA A;  4MHX A;  1ED9 A;  5L0K A;  3UO0 A;  3NKO A;  1KHK A;  5AJ9 A;  3UN3 A;  3WAW A;  4GTY A;  1E1Z P;  1Y7A A;  5C66 A;  1N2L A;  4CXK A;  3DYC A;  3WAV A;  1KH7 A;  1B8J A;  1ELX A;  1URA A;  2GSN A;  3LXQ A;  3MK1 A;  1E3C P;  1ELZ A;  4YR1 A;  5INH A;  4KAY A;  2IUC A;  3Q3Q A;  1FSU A;  3M8Z A;  4QAX A;  3IGY B;  3SZY A;  3WBH A;  4N7T A;  3NKN A;  5TJ3 A;  1KHN A;  1AJB A;  3ED4 A;  3M7V A;  4ZG7 A;  4UOO A;  2G9Y A;  4FDJ A;  3IDD A;  4UOR A;  2XR9 A;  4GTX A;  1EQJ A;  1E33 P;  1ED8 A;  4CXS A;  2RH6 A;  4LR7 A;  2W8D A;  4LRB A;  3BDH A;  4FDI A;  5LIA A;  2W5V A;  1K7H A;  1E2S P;  1ZED A;  2W5X A;  4MY4 A;  4UPK A;  3BDG A;  1ALI A;  4KM4 A;  4LRC A;  4CYS A;  4GTW A;  1EW8 A;  1EW9 A;  2VQR A;  3M8Y A;  3NKP A;  1ELY A;  1AJD A;  4LRF A;  1EJJ A;  1SHQ A;  4LR8 A;  4B56 A;  5DLV A;  5LRM A;  3WAY A;  3OT9 A;  1HDH A;  1AJA A;  2W5W A;  2IFY A;  3SZZ A;  4CYR A;  4KJD A;  4ZG6 A;  3UN5 A;  3WAX A;  1KH9 A;  2ZKT A;  3T01 A;  4UPL A;  3BDF A;  4LQY A;  3KD8 A;  5L0E A;  3E2D A;  3MK2 A;  3NKR A;  4UPI A;  2W5Q A;  4LR9 A;  3T00 A;  2GA3 A;  4UOP A;  1KHL A;  3UN2 A;  5EGH A;  5L0B A;  2GSO A;  4LRA A;  3NKM A;  4NWX A;  1AJC A;  4TN0 A;  4KJG A;  2W8S A;  4NWJ A;  5KXA A;  1EW2 A;  1O98 A;  3IGZ B;  1URB A;  2W5S A;  1AUK A;  1EI6 A;  3DPC A;  2GLQ A;  1ZEF A;  4UPH A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...