4YR1A

Crystal structure of e. coli alkaline phosphatase d101a/d153a in complex with inorganic phosphate
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
443
structure length
443
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTASAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQAATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLKSA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
molecule tags Hydrolase
total genus 155
structure length 443
sequence length 443
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4yr1A00
4GTZA 1Y7AA 3TWZA 1ZEDA 1E33P 2W5WA 4LR2A 1ALHA 1KHKA 4MHXA 3TG0A 3E2DA 3UO0A 1EW9A 3IGZB 3TX0A 3NKMA 4QAXA 4KJGA 2D1GA 2W5XA 1E1ZP 4LR8A 2GSUA 3UN5A 2W5QA 3A52A 4CXUA 3B5QA 4GTXA 4LRDA 5DLVA 1ELXA 4GTYA 2W5SA 3M8YA 2W5RA 1FSUA 2ANHA 3BDGB 3WAXA 3ED4A 4UOOA 5C66A 5DLWA 3DPCA 1P49A 1KHJA 4CYSA 4LRBA 3DYCA 3NKNA 4LRCA 5GRRA 1ED9A 4ZGAA 4UPLA 4NWXA 2GSOA 3NKOA 4LREA 1E3CP 2GA3A 2W5TA 3WAWA 5EGHA 5KXAA 5LQQA 1ED8A 4LRAA 3Q3QA 1EI6A 3CMRA 2XRGA 4UPKA 2X98A 4UPHA 4LQYA 4LR7A 5GOVA 5IJSA 4LR9A 1O98A 2W8SA 5TJ3A 5LRMA 3WAYA 4CXSA 1ALIA 1KH9A 2QZUA 1AJCA 1EW2A 3T01A 5AJ9A 5IJQA 4MIVA 3LXQA 1EQJA 3IDDA 4LRFA 5L0BA 2XR9A 4CXKA 1KHNA 5DLTA 4KAYA 4NWJA 1N2KA 3UN2A 1HQAA 3WAVA 1KHLA 1KH4A 2W8DA 4UPIA 1AJAA 4B56A 5HRTA 2ZKTA 3NKQA 1ANIA 1AUKA 2GSNA 4ZG6A 1ALJA 5INHA 4FDJA 2VQRA 1B8JA 4ZG7A 1SHQA 3SZYA 2W5VA 3MK0A 3NKPA 5K4PA 1URAA 2IUCA 4ZG9A 1EJJA 3UN3A 1URBA 1ELYA 3MK2A 3BDFA 2IFYA 4MY4A 1N2LA 4FDIA 4GTWA 1ALKA 4UORA 3MK1A 2G9YA 1HDHA 2IUCB 4UOPA 3KD8A 1O99A 3OT9A 1EW8A 4N7TA 5LIAA 3T02A 1AJDA 3BDGA 1ELZA 1Y6VA 1KH7A 4CYRA 1E2SP 1K7HA 5LRNA 4YR1A 1SHNA 1ANJA 3IGYB 1ZEFA 3NVLA 4KJDA 5EGEA 5L0EA 3NKRA 4TN0A 3UNYA 1AJBA 1KH5A 2GLQA 3T00A 3M8ZA 4KM4A 3M8WA 3SZZA 1HJKA 1ZEBA 3WBHA 4KAVA 3BDHA 2RH6A 3M7VA 5L0KA
chains in the Genus database with same CATH superfamily
4GTZA 1Y7AA 3TWZA 1ZEDA 1E33P 2W5WA 4LR2A 1ALHA 1KHKA 4MHXA 3TG0A 3E2DA 3UO0A 1EW9A 3IGZB 3TX0A 3NKMA 4QAXA 4KJGA 2D1GA 2W5XA 1E1ZP 4LR8A 2GSUA 3UN5A 2W5QA 3A52A 4CXUA 3B5QA 4GTXA 4LRDA 5DLVA 1ELXA 4GTYA 2W5SA 3M8YA 2W5RA 1FSUA 2ANHA 3BDGB 3WAXA 3ED4A 4UOOA 5C66A 5DLWA 3DPCA 1P49A 1KHJA 4CYSA 4LRBA 3DYCA 3NKNA 4LRCA 5GRRA 1ED9A 4ZGAA 4UPLA 4NWXA 2GSOA 3NKOA 4LREA 1E3CP 2GA3A 2W5TA 3WAWA 5EGHA 5KXAA 5LQQA 1ED8A 4LRAA 3Q3QA 1EI6A 3CMRA 2XRGA 4UPKA 2X98A 4UPHA 4LQYA 4LR7A 5GOVA 5IJSA 4LR9A 1O98A 2W8SA 5TJ3A 5LRMA 3WAYA 4CXSA 1ALIA 1KH9A 2QZUA 1AJCA 1EW2A 3T01A 5AJ9A 5IJQA 4MIVA 3LXQA 1EQJA 3IDDA 4LRFA 5L0BA 2XR9A 4CXKA 1KHNA 5DLTA 4KAYA 4NWJA 1N2KA 3UN2A 1HQAA 3WAVA 1KHLA 1KH4A 2W8DA 4UPIA 1AJAA 4B56A 5HRTA 2ZKTA 3NKQA 1ANIA 1AUKA 2GSNA 4ZG6A 1ALJA 5INHA 4FDJA 2VQRA 1B8JA 4ZG7A 1SHQA 3SZYA 2W5VA 3MK0A 3NKPA 5K4PA 1URAA 2IUCA 4ZG9A 1EJJA 3UN3A 1URBA 1ELYA 3MK2A 3BDFA 2IFYA 4MY4A 1N2LA 4FDIA 4GTWA 1ALKA 4UORA 3MK1A 2G9YA 1HDHA 2IUCB 4UOPA 3KD8A 1O99A 3OT9A 1EW8A 4N7TA 5LIAA 3T02A 1AJDA 3BDGA 1ELZA 1Y6VA 1KH7A 4CYRA 1E2SP 1K7HA 5LRNA 4YR1A 1SHNA 1ANJA 3IGYB 1ZEFA 3NVLA 4KJDA 5EGEA 5L0EA 3NKRA 4TN0A 3UNYA 1AJBA 1KH5A 2GLQA 3T00A 3M8ZA 4KM4A 3M8WA 3SZZA 1HJKA 1ZEBA 3WBHA 4KAVA 3BDHA 2RH6A 3M7VA 5L0KA
chains in the Genus database with same CATH topology
4GTZA 1Y7AA 3TWZA 1ZEDA 1E33P 2W5WA 4LR2A 1ALHA 1KHKA 4MHXA 3TG0A 3E2DA 3UO0A 1EW9A 3IGZB 3TX0A 3NKMA 4QAXA 4KJGA 2D1GA 2W5XA 1E1ZP 4LR8A 2GSUA 3UN5A 2W5QA 3A52A 4CXUA 3B5QA 4GTXA 4LRDA 5DLVA 1ELXA 4GTYA 2W5SA 3M8YA 2W5RA 1FSUA 2ANHA 3BDGB 3WAXA 3ED4A 4UOOA 5C66A 5DLWA 3DPCA 1P49A 1KHJA 4CYSA 4LRBA 3DYCA 3NKNA 4LRCA 5GRRA 1ED9A 4ZGAA 4UPLA 4NWXA 2GSOA 3NKOA 4LREA 1E3CP 2GA3A 2W5TA 3WAWA 5EGHA 5KXAA 5LQQA 1ED8A 4LRAA 3Q3QA 1EI6A 3CMRA 2XRGA 4UPKA 2X98A 4UPHA 4LQYA 4LR7A 5GOVA 5IJSA 4LR9A 1O98A 2W8SA 5TJ3A 5LRMA 3WAYA 4CXSA 1ALIA 1KH9A 2QZUA 1AJCA 1EW2A 3T01A 5AJ9A 5IJQA 4MIVA 3LXQA 1EQJA 3IDDA 4LRFA 5L0BA 2XR9A 4CXKA 1KHNA 5DLTA 4KAYA 4NWJA 1N2KA 3UN2A 1HQAA 3WAVA 1KHLA 1KH4A 2W8DA 4UPIA 1AJAA 4B56A 5HRTA 2ZKTA 3NKQA 1ANIA 1AUKA 2GSNA 4ZG6A 1ALJA 5INHA 4FDJA 2VQRA 1B8JA 4ZG7A 1SHQA 3SZYA 2W5VA 3MK0A 3NKPA 5K4PA 1URAA 2IUCA 4ZG9A 1EJJA 3UN3A 1URBA 1ELYA 3MK2A 3BDFA 2IFYA 4MY4A 1N2LA 4FDIA 4GTWA 1ALKA 4UORA 3MK1A 2G9YA 1HDHA 2IUCB 4UOPA 3KD8A 1O99A 3OT9A 1EW8A 4N7TA 5LIAA 3T02A 1AJDA 3BDGA 1ELZA 1Y6VA 1KH7A 4CYRA 1E2SP 1K7HA 5LRNA 4YR1A 1SHNA 1ANJA 3IGYB 1ZEFA 3NVLA 4KJDA 5EGEA 5L0EA 3NKRA 4TN0A 3UNYA 1AJBA 1KH5A 2GLQA 3T00A 3M8ZA 4KM4A 3M8WA 3SZZA 1HJKA 1ZEBA 3WBHA 4KAVA 3BDHA 2RH6A 3M7VA 5L0KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTZ A;  1Y7A A;  3TWZ A;  1ZED A;  1E33 P;  2W5W A;  4LR2 A;  1ALH A;  1KHK A;  4MHX A;  3TG0 A;  3E2D A;  3UO0 A;  1EW9 A;  3IGZ B;  3TX0 A;  3NKM A;  4QAX A;  4KJG A;  2D1G A;  2W5X A;  1E1Z P;  4LR8 A;  2GSU A;  3UN5 A;  2W5Q A;  3A52 A;  4CXU A;  3B5Q A;  4GTX A;  4LRD A;  5DLV A;  1ELX A;  4GTY A;  2W5S A;  3M8Y A;  2W5R A;  1FSU A;  2ANH A;  3BDG B;  3WAX A;  3ED4 A;  4UOO A;  5C66 A;  5DLW A;  3DPC A;  1P49 A;  1KHJ A;  4CYS A;  4LRB A;  3DYC A;  3NKN A;  4LRC A;  5GRR A;  1ED9 A;  4ZGA A;  4UPL A;  4NWX A;  2GSO A;  3NKO A;  4LRE A;  1E3C P;  2GA3 A;  2W5T A;  3WAW A;  5EGH A;  5KXA A;  5LQQ A;  1ED8 A;  4LRA A;  3Q3Q A;  1EI6 A;  3CMR A;  2XRG A;  4UPK A;  2X98 A;  4UPH A;  4LQY A;  4LR7 A;  5GOV A;  5IJS A;  4LR9 A;  1O98 A;  2W8S A;  5TJ3 A;  5LRM A;  3WAY A;  4CXS A;  1ALI A;  1KH9 A;  2QZU A;  1AJC A;  1EW2 A;  3T01 A;  5AJ9 A;  5IJQ A;  4MIV A;  3LXQ A;  1EQJ A;  3IDD A;  4LRF A;  5L0B A;  2XR9 A;  4CXK A;  1KHN A;  5DLT A;  4KAY A;  4NWJ A;  1N2K A;  3UN2 A;  1HQA A;  3WAV A;  1KHL A;  1KH4 A;  2W8D A;  4UPI A;  1AJA A;  4B56 A;  5HRT A;  2ZKT A;  3NKQ A;  1ANI A;  1AUK A;  2GSN A;  4ZG6 A;  1ALJ A;  5INH A;  4FDJ A;  2VQR A;  1B8J A;  4ZG7 A;  1SHQ A;  3SZY A;  2W5V A;  3MK0 A;  3NKP A;  5K4P A;  1URA A;  2IUC A;  4ZG9 A;  1EJJ A;  3UN3 A;  1URB A;  1ELY A;  3MK2 A;  3BDF A;  2IFY A;  4MY4 A;  1N2L A;  4FDI A;  4GTW A;  1ALK A;  4UOR A;  3MK1 A;  2G9Y A;  1HDH A;  2IUC B;  4UOP A;  3KD8 A;  1O99 A;  3OT9 A;  1EW8 A;  4N7T A;  5LIA A;  3T02 A;  1AJD A;  3BDG A;  1ELZ A;  1Y6V A;  1KH7 A;  4CYR A;  1E2S P;  1K7H A;  5LRN A;  4YR1 A;  1SHN A;  1ANJ A;  3IGY B;  1ZEF A;  3NVL A;  4KJD A;  5EGE A;  5L0E A;  3NKR A;  4TN0 A;  3UNY A;  1AJB A;  1KH5 A;  2GLQ A;  3T00 A;  3M8Z A;  4KM4 A;  3M8W A;  3SZZ A;  1HJK A;  1ZEB A;  3WBH A;  4KAV A;  3BDH A;  2RH6 A;  3M7V A;  5L0K A; 
#chains in the Genus database with same CATH topology
 4GTZ A;  1Y7A A;  3TWZ A;  1ZED A;  1E33 P;  2W5W A;  4LR2 A;  1ALH A;  1KHK A;  4MHX A;  3TG0 A;  3E2D A;  3UO0 A;  1EW9 A;  3IGZ B;  3TX0 A;  3NKM A;  4QAX A;  4KJG A;  2D1G A;  2W5X A;  1E1Z P;  4LR8 A;  2GSU A;  3UN5 A;  2W5Q A;  3A52 A;  4CXU A;  3B5Q A;  4GTX A;  4LRD A;  5DLV A;  1ELX A;  4GTY A;  2W5S A;  3M8Y A;  2W5R A;  1FSU A;  2ANH A;  3BDG B;  3WAX A;  3ED4 A;  4UOO A;  5C66 A;  5DLW A;  3DPC A;  1P49 A;  1KHJ A;  4CYS A;  4LRB A;  3DYC A;  3NKN A;  4LRC A;  5GRR A;  1ED9 A;  4ZGA A;  4UPL A;  4NWX A;  2GSO A;  3NKO A;  4LRE A;  1E3C P;  2GA3 A;  2W5T A;  3WAW A;  5EGH A;  5KXA A;  5LQQ A;  1ED8 A;  4LRA A;  3Q3Q A;  1EI6 A;  3CMR A;  2XRG A;  4UPK A;  2X98 A;  4UPH A;  4LQY A;  4LR7 A;  5GOV A;  5IJS A;  4LR9 A;  1O98 A;  2W8S A;  5TJ3 A;  5LRM A;  3WAY A;  4CXS A;  1ALI A;  1KH9 A;  2QZU A;  1AJC A;  1EW2 A;  3T01 A;  5AJ9 A;  5IJQ A;  4MIV A;  3LXQ A;  1EQJ A;  3IDD A;  4LRF A;  5L0B A;  2XR9 A;  4CXK A;  1KHN A;  5DLT A;  4KAY A;  4NWJ A;  1N2K A;  3UN2 A;  1HQA A;  3WAV A;  1KHL A;  1KH4 A;  2W8D A;  4UPI A;  1AJA A;  4B56 A;  5HRT A;  2ZKT A;  3NKQ A;  1ANI A;  1AUK A;  2GSN A;  4ZG6 A;  1ALJ A;  5INH A;  4FDJ A;  2VQR A;  1B8J A;  4ZG7 A;  1SHQ A;  3SZY A;  2W5V A;  3MK0 A;  3NKP A;  5K4P A;  1URA A;  2IUC A;  4ZG9 A;  1EJJ A;  3UN3 A;  1URB A;  1ELY A;  3MK2 A;  3BDF A;  2IFY A;  4MY4 A;  1N2L A;  4FDI A;  4GTW A;  1ALK A;  4UOR A;  3MK1 A;  2G9Y A;  1HDH A;  2IUC B;  4UOP A;  3KD8 A;  1O99 A;  3OT9 A;  1EW8 A;  4N7T A;  5LIA A;  3T02 A;  1AJD A;  3BDG A;  1ELZ A;  1Y6V A;  1KH7 A;  4CYR A;  1E2S P;  1K7H A;  5LRN A;  4YR1 A;  1SHN A;  1ANJ A;  3IGY B;  1ZEF A;  3NVL A;  4KJD A;  5EGE A;  5L0E A;  3NKR A;  4TN0 A;  3UNY A;  1AJB A;  1KH5 A;  2GLQ A;  3T00 A;  3M8Z A;  4KM4 A;  3M8W A;  3SZZ A;  1HJK A;  1ZEB A;  3WBH A;  4KAV A;  3BDH A;  2RH6 A;  3M7V A;  5L0K A; 
#chains in the Genus database with same CATH homology
 4GTZ A;  1Y7A A;  3TWZ A;  1ZED A;  1E33 P;  2W5W A;  4LR2 A;  1ALH A;  1KHK A;  4MHX A;  3TG0 A;  3E2D A;  3UO0 A;  1EW9 A;  3IGZ B;  3TX0 A;  3NKM A;  4QAX A;  4KJG A;  2D1G A;  2W5X A;  1E1Z P;  4LR8 A;  2GSU A;  3UN5 A;  2W5Q A;  3A52 A;  4CXU A;  3B5Q A;  4GTX A;  4LRD A;  5DLV A;  1ELX A;  4GTY A;  2W5S A;  3M8Y A;  2W5R A;  1FSU A;  2ANH A;  3BDG B;  3WAX A;  3ED4 A;  4UOO A;  5C66 A;  5DLW A;  3DPC A;  1P49 A;  1KHJ A;  4CYS A;  4LRB A;  3DYC A;  3NKN A;  4LRC A;  5GRR A;  1ED9 A;  4ZGA A;  4UPL A;  4NWX A;  2GSO A;  3NKO A;  4LRE A;  1E3C P;  2GA3 A;  2W5T A;  3WAW A;  5EGH A;  5KXA A;  5LQQ A;  1ED8 A;  4LRA A;  3Q3Q A;  1EI6 A;  3CMR A;  2XRG A;  4UPK A;  2X98 A;  4UPH A;  4LQY A;  4LR7 A;  5GOV A;  5IJS A;  4LR9 A;  1O98 A;  2W8S A;  5TJ3 A;  5LRM A;  3WAY A;  4CXS A;  1ALI A;  1KH9 A;  2QZU A;  1AJC A;  1EW2 A;  3T01 A;  5AJ9 A;  5IJQ A;  4MIV A;  3LXQ A;  1EQJ A;  3IDD A;  4LRF A;  5L0B A;  2XR9 A;  4CXK A;  1KHN A;  5DLT A;  4KAY A;  4NWJ A;  1N2K A;  3UN2 A;  1HQA A;  3WAV A;  1KHL A;  1KH4 A;  2W8D A;  4UPI A;  1AJA A;  4B56 A;  5HRT A;  2ZKT A;  3NKQ A;  1ANI A;  1AUK A;  2GSN A;  4ZG6 A;  1ALJ A;  5INH A;  4FDJ A;  2VQR A;  1B8J A;  4ZG7 A;  1SHQ A;  3SZY A;  2W5V A;  3MK0 A;  3NKP A;  5K4P A;  1URA A;  2IUC A;  4ZG9 A;  1EJJ A;  3UN3 A;  1URB A;  1ELY A;  3MK2 A;  3BDF A;  2IFY A;  4MY4 A;  1N2L A;  4FDI A;  4GTW A;  1ALK A;  4UOR A;  3MK1 A;  2G9Y A;  1HDH A;  2IUC B;  4UOP A;  3KD8 A;  1O99 A;  3OT9 A;  1EW8 A;  4N7T A;  5LIA A;  3T02 A;  1AJD A;  3BDG A;  1ELZ A;  1Y6V A;  1KH7 A;  4CYR A;  1E2S P;  1K7H A;  5LRN A;  4YR1 A;  1SHN A;  1ANJ A;  3IGY B;  1ZEF A;  3NVL A;  4KJD A;  5EGE A;  5L0E A;  3NKR A;  4TN0 A;  3UNY A;  1AJB A;  1KH5 A;  2GLQ A;  3T00 A;  3M8Z A;  4KM4 A;  3M8W A;  3SZZ A;  1HJK A;  1ZEB A;  3WBH A;  4KAV A;  3BDH A;  2RH6 A;  3M7V A;  5L0K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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