4YR1A

Crystal structure of e. coli alkaline phosphatase d101a/d153a in complex with inorganic phosphate
Total Genus 155
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
155
Knots found
sequence length
443
structure length
443
Chain Sequence
NRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTASAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQAATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLKSA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Extensive site-directed mutagenesis reveals interconnected functional units in the Alkaline Phosphatase active site.
pubmed doi rcsb
source organism Escherichia coli (strain k12)
total genus 155
structure length 443
sequence length 443
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2015-03-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4yr1A00
1KH4A 2ANHA 3IDDA 5INHA 3NKQA 3UNYA 2GSOA 4LR2A 2IUCB 1EW9A 5LQQA 3UN2A 2W5SA 5IJSA 5L0BA 3TG0A 3NKRA 5L0KA 4YR1A 2GSUA 3UN5A 4MY4A 4QAXA 3M8WA 1E2SP 4N7TA 4UOOA 5K4PA 1ALIA 1ELYA 4KJDA 4LRDA 4UORA 3WBHA 1KH5A 1Y7AA 1KH7A 3DYCA 4ZG7A 2XR9A 4GTXA 3SZZA 1SHNA 5TJ3A 2W5XA 3IGZB 4ZG6A 5LRMA 1HDHA 1HQAA 1ALKA 4MHXA 5DLWA 3CMRA 4LQYA 1KHJA 1HJKA 2W5VA 3MK1A 4LRAA 4NWXA 2GSNA 1AJDA 3MK2A 4UOPA 1EW2A 1AJBA 2IUCA 2QZUA 3M7VA 4KJGA 4TN0A 4UPHA 5GOVA 3T02A 3WAXA 4UPIA 4KM4A 2W5QA 1E1ZP 5HRTA 1Y6VA 4B56A 1ED9A 3SZYA 1FSUA 4FDJA 2GLQA 3E2DA 3TWZA 4CYRA 4LREA 3NKNA 4GTWA 4LR7A 3WAVA 3WAWA 2X98A 3BDGA 1EW8A 3T01A 3TX0A 3OT9A 1SHQA 4NWJA 1P49A 1KHLA 1KHKA 1AUKA 3BDFA 5L0EA 1ALHA 1N2LA 4GTYA 5EGEA 1ELZA 3DPCA 3T00A 1URAA 3UO0A 1ANIA 1ALJA 4LRBA 1AJAA 4LRFA 2W5RA 1ED8A 2G9YA 1AJCA 2XRGA 1ZEDA 3NVLA 1B8JA 5KXAA 3Q3QA 5EGHA 3MK0A 4GTZA 1KHNA 1ZEFA 1O98A 3ED4A 2VQRA 2IFYA 5GRRA 1ZEBA 4KAVA 3IGYB 1E3CP 2RH6A 5IJQA 4LR8A 3M8ZA 5LIAA 4UPKA 3NKOA 4UPLA 1ANJA 1URBA 3KD8A 5DLVA 4KAYA 2W5TA 5DLTA 4CXKA 1EJJA 3A52A 4ZGAA 4CXSA 4MIVA 4CYSA 3WAYA 3BDHA 2D1GA 4FDIA 3M8YA 1KH9A 2GA3A 3LXQA 1N2KA 1EQJA 2ZKTA 3NKPA 4CXUA 3BDGB 3NKMA 3UN3A 4ZG9A 5AJ9A 5C66A 1E33P 4LRCA 4LR9A 1EI6A 5LRNA 2W8DA 1K7HA 1O99A 3B5QA 2W8SA 2W5WA 1ELXA
chains in the Genus database with same CATH superfamily
1KH4A 2ANHA 3IDDA 5INHA 3NKQA 3UNYA 2GSOA 4LR2A 2IUCB 1EW9A 5LQQA 3UN2A 2W5SA 5IJSA 5L0BA 3TG0A 3NKRA 5L0KA 4YR1A 2GSUA 3UN5A 4MY4A 4QAXA 3M8WA 1E2SP 4N7TA 4UOOA 5K4PA 1ALIA 1ELYA 4KJDA 4LRDA 4UORA 3WBHA 1KH5A 1Y7AA 1KH7A 3DYCA 4ZG7A 2XR9A 4GTXA 3SZZA 1SHNA 5TJ3A 2W5XA 3IGZB 4ZG6A 5LRMA 1HDHA 1HQAA 1ALKA 4MHXA 5DLWA 3CMRA 4LQYA 1KHJA 1HJKA 2W5VA 3MK1A 4LRAA 4NWXA 2GSNA 1AJDA 3MK2A 4UOPA 1EW2A 1AJBA 2IUCA 2QZUA 3M7VA 4KJGA 4TN0A 4UPHA 5GOVA 3T02A 3WAXA 4UPIA 4KM4A 2W5QA 1E1ZP 5HRTA 1Y6VA 4B56A 1ED9A 3SZYA 1FSUA 4FDJA 2GLQA 3E2DA 3TWZA 4CYRA 4LREA 3NKNA 4GTWA 4LR7A 3WAVA 3WAWA 2X98A 3BDGA 1EW8A 3T01A 3TX0A 3OT9A 1SHQA 4NWJA 1P49A 1KHLA 1KHKA 1AUKA 3BDFA 5L0EA 1ALHA 1N2LA 4GTYA 5EGEA 1ELZA 3DPCA 3T00A 1URAA 3UO0A 1ANIA 1ALJA 4LRBA 1AJAA 4LRFA 2W5RA 1ED8A 2G9YA 1AJCA 2XRGA 1ZEDA 3NVLA 1B8JA 5KXAA 3Q3QA 5EGHA 3MK0A 4GTZA 1KHNA 1ZEFA 1O98A 3ED4A 2VQRA 2IFYA 5GRRA 1ZEBA 4KAVA 3IGYB 1E3CP 2RH6A 5IJQA 4LR8A 3M8ZA 5LIAA 4UPKA 3NKOA 4UPLA 1ANJA 1URBA 3KD8A 5DLVA 4KAYA 2W5TA 5DLTA 4CXKA 1EJJA 3A52A 4ZGAA 4CXSA 4MIVA 4CYSA 3WAYA 3BDHA 2D1GA 4FDIA 3M8YA 1KH9A 2GA3A 3LXQA 1N2KA 1EQJA 2ZKTA 3NKPA 4CXUA 3BDGB 3NKMA 3UN3A 4ZG9A 5AJ9A 5C66A 1E33P 4LRCA 4LR9A 1EI6A 5LRNA 2W8DA 1K7HA 1O99A 3B5QA 2W8SA 2W5WA 1ELXA
chains in the Genus database with same CATH topology
1KH4A 2ANHA 3IDDA 5INHA 3NKQA 3UNYA 2GSOA 4LR2A 2IUCB 1EW9A 5LQQA 3UN2A 2W5SA 5IJSA 5L0BA 3TG0A 3NKRA 5L0KA 4YR1A 2GSUA 3UN5A 4MY4A 4QAXA 3M8WA 1E2SP 4N7TA 4UOOA 5K4PA 1ALIA 1ELYA 4KJDA 4LRDA 4UORA 3WBHA 1KH5A 1Y7AA 1KH7A 3DYCA 4ZG7A 2XR9A 4GTXA 3SZZA 1SHNA 5TJ3A 2W5XA 3IGZB 4ZG6A 5LRMA 1HDHA 1HQAA 1ALKA 4MHXA 5DLWA 3CMRA 4LQYA 1KHJA 1HJKA 2W5VA 3MK1A 4LRAA 4NWXA 2GSNA 1AJDA 3MK2A 4UOPA 1EW2A 1AJBA 2IUCA 2QZUA 3M7VA 4KJGA 4TN0A 4UPHA 5GOVA 3T02A 3WAXA 4UPIA 4KM4A 2W5QA 1E1ZP 5HRTA 1Y6VA 4B56A 1ED9A 3SZYA 1FSUA 4FDJA 2GLQA 3E2DA 3TWZA 4CYRA 4LREA 3NKNA 4GTWA 4LR7A 3WAVA 3WAWA 2X98A 3BDGA 1EW8A 3T01A 3TX0A 3OT9A 1SHQA 4NWJA 1P49A 1KHLA 1KHKA 1AUKA 3BDFA 5L0EA 1ALHA 1N2LA 4GTYA 5EGEA 1ELZA 3DPCA 3T00A 1URAA 3UO0A 1ANIA 1ALJA 4LRBA 1AJAA 4LRFA 2W5RA 1ED8A 2G9YA 1AJCA 2XRGA 1ZEDA 3NVLA 1B8JA 5KXAA 3Q3QA 5EGHA 3MK0A 4GTZA 1KHNA 1ZEFA 1O98A 3ED4A 2VQRA 2IFYA 5GRRA 1ZEBA 4KAVA 3IGYB 1E3CP 2RH6A 5IJQA 4LR8A 3M8ZA 5LIAA 4UPKA 3NKOA 4UPLA 1ANJA 1URBA 3KD8A 5DLVA 4KAYA 2W5TA 5DLTA 4CXKA 1EJJA 3A52A 4ZGAA 4CXSA 4MIVA 4CYSA 3WAYA 3BDHA 2D1GA 4FDIA 3M8YA 1KH9A 2GA3A 3LXQA 1N2KA 1EQJA 2ZKTA 3NKPA 4CXUA 3BDGB 3NKMA 3UN3A 4ZG9A 5AJ9A 5C66A 1E33P 4LRCA 4LR9A 1EI6A 5LRNA 2W8DA 1K7HA 1O99A 3B5QA 2W8SA 2W5WA 1ELXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KH4 A;  2ANH A;  3IDD A;  5INH A;  3NKQ A;  3UNY A;  2GSO A;  4LR2 A;  2IUC B;  1EW9 A;  5LQQ A;  3UN2 A;  2W5S A;  5IJS A;  5L0B A;  3TG0 A;  3NKR A;  5L0K A;  4YR1 A;  2GSU A;  3UN5 A;  4MY4 A;  4QAX A;  3M8W A;  1E2S P;  4N7T A;  4UOO A;  5K4P A;  1ALI A;  1ELY A;  4KJD A;  4LRD A;  4UOR A;  3WBH A;  1KH5 A;  1Y7A A;  1KH7 A;  3DYC A;  4ZG7 A;  2XR9 A;  4GTX A;  3SZZ A;  1SHN A;  5TJ3 A;  2W5X A;  3IGZ B;  4ZG6 A;  5LRM A;  1HDH A;  1HQA A;  1ALK A;  4MHX A;  5DLW A;  3CMR A;  4LQY A;  1KHJ A;  1HJK A;  2W5V A;  3MK1 A;  4LRA A;  4NWX A;  2GSN A;  1AJD A;  3MK2 A;  4UOP A;  1EW2 A;  1AJB A;  2IUC A;  2QZU A;  3M7V A;  4KJG A;  4TN0 A;  4UPH A;  5GOV A;  3T02 A;  3WAX A;  4UPI A;  4KM4 A;  2W5Q A;  1E1Z P;  5HRT A;  1Y6V A;  4B56 A;  1ED9 A;  3SZY A;  1FSU A;  4FDJ A;  2GLQ A;  3E2D A;  3TWZ A;  4CYR A;  4LRE A;  3NKN A;  4GTW A;  4LR7 A;  3WAV A;  3WAW A;  2X98 A;  3BDG A;  1EW8 A;  3T01 A;  3TX0 A;  3OT9 A;  1SHQ A;  4NWJ A;  1P49 A;  1KHL A;  1KHK A;  1AUK A;  3BDF A;  5L0E A;  1ALH A;  1N2L A;  4GTY A;  5EGE A;  1ELZ A;  3DPC A;  3T00 A;  1URA A;  3UO0 A;  1ANI A;  1ALJ A;  4LRB A;  1AJA A;  4LRF A;  2W5R A;  1ED8 A;  2G9Y A;  1AJC A;  2XRG A;  1ZED A;  3NVL A;  1B8J A;  5KXA A;  3Q3Q A;  5EGH A;  3MK0 A;  4GTZ A;  1KHN A;  1ZEF A;  1O98 A;  3ED4 A;  2VQR A;  2IFY A;  5GRR A;  1ZEB A;  4KAV A;  3IGY B;  1E3C P;  2RH6 A;  5IJQ A;  4LR8 A;  3M8Z A;  5LIA A;  4UPK A;  3NKO A;  4UPL A;  1ANJ A;  1URB A;  3KD8 A;  5DLV A;  4KAY A;  2W5T A;  5DLT A;  4CXK A;  1EJJ A;  3A52 A;  4ZGA A;  4CXS A;  4MIV A;  4CYS A;  3WAY A;  3BDH A;  2D1G A;  4FDI A;  3M8Y A;  1KH9 A;  2GA3 A;  3LXQ A;  1N2K A;  1EQJ A;  2ZKT A;  3NKP A;  4CXU A;  3BDG B;  3NKM A;  3UN3 A;  4ZG9 A;  5AJ9 A;  5C66 A;  1E33 P;  4LRC A;  4LR9 A;  1EI6 A;  5LRN A;  2W8D A;  1K7H A;  1O99 A;  3B5Q A;  2W8S A;  2W5W A;  1ELX A; 
#chains in the Genus database with same CATH topology
 1KH4 A;  2ANH A;  3IDD A;  5INH A;  3NKQ A;  3UNY A;  2GSO A;  4LR2 A;  2IUC B;  1EW9 A;  5LQQ A;  3UN2 A;  2W5S A;  5IJS A;  5L0B A;  3TG0 A;  3NKR A;  5L0K A;  4YR1 A;  2GSU A;  3UN5 A;  4MY4 A;  4QAX A;  3M8W A;  1E2S P;  4N7T A;  4UOO A;  5K4P A;  1ALI A;  1ELY A;  4KJD A;  4LRD A;  4UOR A;  3WBH A;  1KH5 A;  1Y7A A;  1KH7 A;  3DYC A;  4ZG7 A;  2XR9 A;  4GTX A;  3SZZ A;  1SHN A;  5TJ3 A;  2W5X A;  3IGZ B;  4ZG6 A;  5LRM A;  1HDH A;  1HQA A;  1ALK A;  4MHX A;  5DLW A;  3CMR A;  4LQY A;  1KHJ A;  1HJK A;  2W5V A;  3MK1 A;  4LRA A;  4NWX A;  2GSN A;  1AJD A;  3MK2 A;  4UOP A;  1EW2 A;  1AJB A;  2IUC A;  2QZU A;  3M7V A;  4KJG A;  4TN0 A;  4UPH A;  5GOV A;  3T02 A;  3WAX A;  4UPI A;  4KM4 A;  2W5Q A;  1E1Z P;  5HRT A;  1Y6V A;  4B56 A;  1ED9 A;  3SZY A;  1FSU A;  4FDJ A;  2GLQ A;  3E2D A;  3TWZ A;  4CYR A;  4LRE A;  3NKN A;  4GTW A;  4LR7 A;  3WAV A;  3WAW A;  2X98 A;  3BDG A;  1EW8 A;  3T01 A;  3TX0 A;  3OT9 A;  1SHQ A;  4NWJ A;  1P49 A;  1KHL A;  1KHK A;  1AUK A;  3BDF A;  5L0E A;  1ALH A;  1N2L A;  4GTY A;  5EGE A;  1ELZ A;  3DPC A;  3T00 A;  1URA A;  3UO0 A;  1ANI A;  1ALJ A;  4LRB A;  1AJA A;  4LRF A;  2W5R A;  1ED8 A;  2G9Y A;  1AJC A;  2XRG A;  1ZED A;  3NVL A;  1B8J A;  5KXA A;  3Q3Q A;  5EGH A;  3MK0 A;  4GTZ A;  1KHN A;  1ZEF A;  1O98 A;  3ED4 A;  2VQR A;  2IFY A;  5GRR A;  1ZEB A;  4KAV A;  3IGY B;  1E3C P;  2RH6 A;  5IJQ A;  4LR8 A;  3M8Z A;  5LIA A;  4UPK A;  3NKO A;  4UPL A;  1ANJ A;  1URB A;  3KD8 A;  5DLV A;  4KAY A;  2W5T A;  5DLT A;  4CXK A;  1EJJ A;  3A52 A;  4ZGA A;  4CXS A;  4MIV A;  4CYS A;  3WAY A;  3BDH A;  2D1G A;  4FDI A;  3M8Y A;  1KH9 A;  2GA3 A;  3LXQ A;  1N2K A;  1EQJ A;  2ZKT A;  3NKP A;  4CXU A;  3BDG B;  3NKM A;  3UN3 A;  4ZG9 A;  5AJ9 A;  5C66 A;  1E33 P;  4LRC A;  4LR9 A;  1EI6 A;  5LRN A;  2W8D A;  1K7H A;  1O99 A;  3B5Q A;  2W8S A;  2W5W A;  1ELX A; 
#chains in the Genus database with same CATH homology
 1KH4 A;  2ANH A;  3IDD A;  5INH A;  3NKQ A;  3UNY A;  2GSO A;  4LR2 A;  2IUC B;  1EW9 A;  5LQQ A;  3UN2 A;  2W5S A;  5IJS A;  5L0B A;  3TG0 A;  3NKR A;  5L0K A;  4YR1 A;  2GSU A;  3UN5 A;  4MY4 A;  4QAX A;  3M8W A;  1E2S P;  4N7T A;  4UOO A;  5K4P A;  1ALI A;  1ELY A;  4KJD A;  4LRD A;  4UOR A;  3WBH A;  1KH5 A;  1Y7A A;  1KH7 A;  3DYC A;  4ZG7 A;  2XR9 A;  4GTX A;  3SZZ A;  1SHN A;  5TJ3 A;  2W5X A;  3IGZ B;  4ZG6 A;  5LRM A;  1HDH A;  1HQA A;  1ALK A;  4MHX A;  5DLW A;  3CMR A;  4LQY A;  1KHJ A;  1HJK A;  2W5V A;  3MK1 A;  4LRA A;  4NWX A;  2GSN A;  1AJD A;  3MK2 A;  4UOP A;  1EW2 A;  1AJB A;  2IUC A;  2QZU A;  3M7V A;  4KJG A;  4TN0 A;  4UPH A;  5GOV A;  3T02 A;  3WAX A;  4UPI A;  4KM4 A;  2W5Q A;  1E1Z P;  5HRT A;  1Y6V A;  4B56 A;  1ED9 A;  3SZY A;  1FSU A;  4FDJ A;  2GLQ A;  3E2D A;  3TWZ A;  4CYR A;  4LRE A;  3NKN A;  4GTW A;  4LR7 A;  3WAV A;  3WAW A;  2X98 A;  3BDG A;  1EW8 A;  3T01 A;  3TX0 A;  3OT9 A;  1SHQ A;  4NWJ A;  1P49 A;  1KHL A;  1KHK A;  1AUK A;  3BDF A;  5L0E A;  1ALH A;  1N2L A;  4GTY A;  5EGE A;  1ELZ A;  3DPC A;  3T00 A;  1URA A;  3UO0 A;  1ANI A;  1ALJ A;  4LRB A;  1AJA A;  4LRF A;  2W5R A;  1ED8 A;  2G9Y A;  1AJC A;  2XRG A;  1ZED A;  3NVL A;  1B8J A;  5KXA A;  3Q3Q A;  5EGH A;  3MK0 A;  4GTZ A;  1KHN A;  1ZEF A;  1O98 A;  3ED4 A;  2VQR A;  2IFY A;  5GRR A;  1ZEB A;  4KAV A;  3IGY B;  1E3C P;  2RH6 A;  5IJQ A;  4LR8 A;  3M8Z A;  5LIA A;  4UPK A;  3NKO A;  4UPL A;  1ANJ A;  1URB A;  3KD8 A;  5DLV A;  4KAY A;  2W5T A;  5DLT A;  4CXK A;  1EJJ A;  3A52 A;  4ZGA A;  4CXS A;  4MIV A;  4CYS A;  3WAY A;  3BDH A;  2D1G A;  4FDI A;  3M8Y A;  1KH9 A;  2GA3 A;  3LXQ A;  1N2K A;  1EQJ A;  2ZKT A;  3NKP A;  4CXU A;  3BDG B;  3NKM A;  3UN3 A;  4ZG9 A;  5AJ9 A;  5C66 A;  1E33 P;  4LRC A;  4LR9 A;  1EI6 A;  5LRN A;  2W8D A;  1K7H A;  1O99 A;  3B5Q A;  2W8S A;  2W5W A;  1ELX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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