3BDHA

Crystal structure of zinc-deficient wild-type e. coli alkaline phosphatase
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 154
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdhA00
1AUKA 4LR2A 5LQQA 5K4PA 5EGEA 1AJCA 3M8ZA 4UPLA 1ANJA 3LXQA 1EJJA 3IDDA 4LREA 1EW2A 4UOPA 2W5VA 1Y6VA 4NWJA 2W5QA 4KJDA 1KH4A 4UOOA 5GOVA 4FDIA 2W5TA 3T01A 5INHA 3BDHA 3NVLA 4UORA 1ED9A 1E2SP 4LRCA 4UPKA 1KH9A 2W5XA 3MK0A 5KXAA 1ELYA 1N2LA 4LQYA 1EI6A 3NKPA 2G9YA 5LIAA 1EW8A 2GSNA 2D1GA 3DYCA 1P49A 1E33P 3OT9A 4LRAA 2X98A 3CMRA 4GTWA 4ZG6A 3WAWA 5LRNA 1Y7AA 1AJBA 3WAXA 5HRTA 3Q3QA 1ALHA 4KM4A 4ZG7A 4YR1A 1HJKA 3MK1A 3UN5A 1FSUA 3NKMA 3IGYB 3NKOA 3B5QA 4ZG9A 5C66A 2W5SA 4B56A 2ZKTA 5LRMA 1KHNA 1SHNA 1ALJA 3M8WA 4KAYA 1KHLA 3NKRA 4CYRA 4MIVA 1KHKA 1E3CP 5DLWA 5EGHA 4FDJA 4LRFA 5IJQA 3DPCA 1E1ZP 3IGZB 2VQRA 4LR7A 3SZYA 1ALKA 1O98A 2GLQA 3NKQA 3SZZA 1KHJA 5L0BA 2W8DA 4KAVA 1KH5A 3MK2A 3UN3A 2QZUA 3A52A 4NWXA 2XR9A 3UO0A 3WAYA 4CYSA 4LR8A 2W5WA 5GRRA 1KH7A 1EW9A 4LRBA 5L0KA 4UPHA 4QAXA 1ANIA 1ELXA 4TN0A 4ZGAA 2IFYA 1ZEDA 1ED8A 3WAVA 3TX0A 2RH6A 3M8YA 1O99A 2XRGA 2W8SA 3TWZA 2W5RA 3BDGA 2IUCB 5TJ3A 4LRDA 2ANHA 4CXKA 4MY4A 1HQAA 3WBHA 5L0EA 4GTXA 4GTYA 1ELZA 3M7VA 3ED4A 4GTZA 1K7HA 3TG0A 4MHXA 1AJAA 5DLVA 5DLTA 3T02A 3BDGB 4CXUA 2IUCA 2GSOA 4CXSA 1SHQA 1AJDA 1B8JA 1N2KA 2GA3A 3NKNA 1URAA 1EQJA 4LR9A 5IJSA 1URBA 4KJGA 4UPIA 5AJ9A 3BDFA 4N7TA 3KD8A 1ZEFA 3UNYA 3E2DA 1ALIA 3UN2A 2GSUA 1ZEBA 3T00A 1HDHA
chains in the Genus database with same CATH superfamily
1AUKA 4LR2A 5LQQA 5K4PA 5EGEA 1AJCA 3M8ZA 4UPLA 1ANJA 3LXQA 1EJJA 3IDDA 4LREA 1EW2A 4UOPA 2W5VA 1Y6VA 4NWJA 2W5QA 4KJDA 1KH4A 4UOOA 5GOVA 4FDIA 2W5TA 3T01A 5INHA 3BDHA 3NVLA 4UORA 1ED9A 1E2SP 4LRCA 4UPKA 1KH9A 2W5XA 3MK0A 5KXAA 1ELYA 1N2LA 4LQYA 1EI6A 3NKPA 2G9YA 5LIAA 1EW8A 2GSNA 2D1GA 3DYCA 1P49A 1E33P 3OT9A 4LRAA 2X98A 3CMRA 4GTWA 4ZG6A 3WAWA 5LRNA 1Y7AA 1AJBA 3WAXA 5HRTA 3Q3QA 1ALHA 4KM4A 4ZG7A 4YR1A 1HJKA 3MK1A 3UN5A 1FSUA 3NKMA 3IGYB 3NKOA 3B5QA 4ZG9A 5C66A 2W5SA 4B56A 2ZKTA 5LRMA 1KHNA 1SHNA 1ALJA 3M8WA 4KAYA 1KHLA 3NKRA 4CYRA 4MIVA 1KHKA 1E3CP 5DLWA 5EGHA 4FDJA 4LRFA 5IJQA 3DPCA 1E1ZP 3IGZB 2VQRA 4LR7A 3SZYA 1ALKA 1O98A 2GLQA 3NKQA 3SZZA 1KHJA 5L0BA 2W8DA 4KAVA 1KH5A 3MK2A 3UN3A 2QZUA 3A52A 4NWXA 2XR9A 3UO0A 3WAYA 4CYSA 4LR8A 2W5WA 5GRRA 1KH7A 1EW9A 4LRBA 5L0KA 4UPHA 4QAXA 1ANIA 1ELXA 4TN0A 4ZGAA 2IFYA 1ZEDA 1ED8A 3WAVA 3TX0A 2RH6A 3M8YA 1O99A 2XRGA 2W8SA 3TWZA 2W5RA 3BDGA 2IUCB 5TJ3A 4LRDA 2ANHA 4CXKA 4MY4A 1HQAA 3WBHA 5L0EA 4GTXA 4GTYA 1ELZA 3M7VA 3ED4A 4GTZA 1K7HA 3TG0A 4MHXA 1AJAA 5DLVA 5DLTA 3T02A 3BDGB 4CXUA 2IUCA 2GSOA 4CXSA 1SHQA 1AJDA 1B8JA 1N2KA 2GA3A 3NKNA 1URAA 1EQJA 4LR9A 5IJSA 1URBA 4KJGA 4UPIA 5AJ9A 3BDFA 4N7TA 3KD8A 1ZEFA 3UNYA 3E2DA 1ALIA 3UN2A 2GSUA 1ZEBA 3T00A 1HDHA
chains in the Genus database with same CATH topology
1AUKA 4LR2A 5LQQA 5K4PA 5EGEA 1AJCA 3M8ZA 4UPLA 1ANJA 3LXQA 1EJJA 3IDDA 4LREA 1EW2A 4UOPA 2W5VA 1Y6VA 4NWJA 2W5QA 4KJDA 1KH4A 4UOOA 5GOVA 4FDIA 2W5TA 3T01A 5INHA 3BDHA 3NVLA 4UORA 1ED9A 1E2SP 4LRCA 4UPKA 1KH9A 2W5XA 3MK0A 5KXAA 1ELYA 1N2LA 4LQYA 1EI6A 3NKPA 2G9YA 5LIAA 1EW8A 2GSNA 2D1GA 3DYCA 1P49A 1E33P 3OT9A 4LRAA 2X98A 3CMRA 4GTWA 4ZG6A 3WAWA 5LRNA 1Y7AA 1AJBA 3WAXA 5HRTA 3Q3QA 1ALHA 4KM4A 4ZG7A 4YR1A 1HJKA 3MK1A 3UN5A 1FSUA 3NKMA 3IGYB 3NKOA 3B5QA 4ZG9A 5C66A 2W5SA 4B56A 2ZKTA 5LRMA 1KHNA 1SHNA 1ALJA 3M8WA 4KAYA 1KHLA 3NKRA 4CYRA 4MIVA 1KHKA 1E3CP 5DLWA 5EGHA 4FDJA 4LRFA 5IJQA 3DPCA 1E1ZP 3IGZB 2VQRA 4LR7A 3SZYA 1ALKA 1O98A 2GLQA 3NKQA 3SZZA 1KHJA 5L0BA 2W8DA 4KAVA 1KH5A 3MK2A 3UN3A 2QZUA 3A52A 4NWXA 2XR9A 3UO0A 3WAYA 4CYSA 4LR8A 2W5WA 5GRRA 1KH7A 1EW9A 4LRBA 5L0KA 4UPHA 4QAXA 1ANIA 1ELXA 4TN0A 4ZGAA 2IFYA 1ZEDA 1ED8A 3WAVA 3TX0A 2RH6A 3M8YA 1O99A 2XRGA 2W8SA 3TWZA 2W5RA 3BDGA 2IUCB 5TJ3A 4LRDA 2ANHA 4CXKA 4MY4A 1HQAA 3WBHA 5L0EA 4GTXA 4GTYA 1ELZA 3M7VA 3ED4A 4GTZA 1K7HA 3TG0A 4MHXA 1AJAA 5DLVA 5DLTA 3T02A 3BDGB 4CXUA 2IUCA 2GSOA 4CXSA 1SHQA 1AJDA 1B8JA 1N2KA 2GA3A 3NKNA 1URAA 1EQJA 4LR9A 5IJSA 1URBA 4KJGA 4UPIA 5AJ9A 3BDFA 4N7TA 3KD8A 1ZEFA 3UNYA 3E2DA 1ALIA 3UN2A 2GSUA 1ZEBA 3T00A 1HDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AUK A;  4LR2 A;  5LQQ A;  5K4P A;  5EGE A;  1AJC A;  3M8Z A;  4UPL A;  1ANJ A;  3LXQ A;  1EJJ A;  3IDD A;  4LRE A;  1EW2 A;  4UOP A;  2W5V A;  1Y6V A;  4NWJ A;  2W5Q A;  4KJD A;  1KH4 A;  4UOO A;  5GOV A;  4FDI A;  2W5T A;  3T01 A;  5INH A;  3BDH A;  3NVL A;  4UOR A;  1ED9 A;  1E2S P;  4LRC A;  4UPK A;  1KH9 A;  2W5X A;  3MK0 A;  5KXA A;  1ELY A;  1N2L A;  4LQY A;  1EI6 A;  3NKP A;  2G9Y A;  5LIA A;  1EW8 A;  2GSN A;  2D1G A;  3DYC A;  1P49 A;  1E33 P;  3OT9 A;  4LRA A;  2X98 A;  3CMR A;  4GTW A;  4ZG6 A;  3WAW A;  5LRN A;  1Y7A A;  1AJB A;  3WAX A;  5HRT A;  3Q3Q A;  1ALH A;  4KM4 A;  4ZG7 A;  4YR1 A;  1HJK A;  3MK1 A;  3UN5 A;  1FSU A;  3NKM A;  3IGY B;  3NKO A;  3B5Q A;  4ZG9 A;  5C66 A;  2W5S A;  4B56 A;  2ZKT A;  5LRM A;  1KHN A;  1SHN A;  1ALJ A;  3M8W A;  4KAY A;  1KHL A;  3NKR A;  4CYR A;  4MIV A;  1KHK A;  1E3C P;  5DLW A;  5EGH A;  4FDJ A;  4LRF A;  5IJQ A;  3DPC A;  1E1Z P;  3IGZ B;  2VQR A;  4LR7 A;  3SZY A;  1ALK A;  1O98 A;  2GLQ A;  3NKQ A;  3SZZ A;  1KHJ A;  5L0B A;  2W8D A;  4KAV A;  1KH5 A;  3MK2 A;  3UN3 A;  2QZU A;  3A52 A;  4NWX A;  2XR9 A;  3UO0 A;  3WAY A;  4CYS A;  4LR8 A;  2W5W A;  5GRR A;  1KH7 A;  1EW9 A;  4LRB A;  5L0K A;  4UPH A;  4QAX A;  1ANI A;  1ELX A;  4TN0 A;  4ZGA A;  2IFY A;  1ZED A;  1ED8 A;  3WAV A;  3TX0 A;  2RH6 A;  3M8Y A;  1O99 A;  2XRG A;  2W8S A;  3TWZ A;  2W5R A;  3BDG A;  2IUC B;  5TJ3 A;  4LRD A;  2ANH A;  4CXK A;  4MY4 A;  1HQA A;  3WBH A;  5L0E A;  4GTX A;  4GTY A;  1ELZ A;  3M7V A;  3ED4 A;  4GTZ A;  1K7H A;  3TG0 A;  4MHX A;  1AJA A;  5DLV A;  5DLT A;  3T02 A;  3BDG B;  4CXU A;  2IUC A;  2GSO A;  4CXS A;  1SHQ A;  1AJD A;  1B8J A;  1N2K A;  2GA3 A;  3NKN A;  1URA A;  1EQJ A;  4LR9 A;  5IJS A;  1URB A;  4KJG A;  4UPI A;  5AJ9 A;  3BDF A;  4N7T A;  3KD8 A;  1ZEF A;  3UNY A;  3E2D A;  1ALI A;  3UN2 A;  2GSU A;  1ZEB A;  3T00 A;  1HDH A; 
#chains in the Genus database with same CATH topology
 1AUK A;  4LR2 A;  5LQQ A;  5K4P A;  5EGE A;  1AJC A;  3M8Z A;  4UPL A;  1ANJ A;  3LXQ A;  1EJJ A;  3IDD A;  4LRE A;  1EW2 A;  4UOP A;  2W5V A;  1Y6V A;  4NWJ A;  2W5Q A;  4KJD A;  1KH4 A;  4UOO A;  5GOV A;  4FDI A;  2W5T A;  3T01 A;  5INH A;  3BDH A;  3NVL A;  4UOR A;  1ED9 A;  1E2S P;  4LRC A;  4UPK A;  1KH9 A;  2W5X A;  3MK0 A;  5KXA A;  1ELY A;  1N2L A;  4LQY A;  1EI6 A;  3NKP A;  2G9Y A;  5LIA A;  1EW8 A;  2GSN A;  2D1G A;  3DYC A;  1P49 A;  1E33 P;  3OT9 A;  4LRA A;  2X98 A;  3CMR A;  4GTW A;  4ZG6 A;  3WAW A;  5LRN A;  1Y7A A;  1AJB A;  3WAX A;  5HRT A;  3Q3Q A;  1ALH A;  4KM4 A;  4ZG7 A;  4YR1 A;  1HJK A;  3MK1 A;  3UN5 A;  1FSU A;  3NKM A;  3IGY B;  3NKO A;  3B5Q A;  4ZG9 A;  5C66 A;  2W5S A;  4B56 A;  2ZKT A;  5LRM A;  1KHN A;  1SHN A;  1ALJ A;  3M8W A;  4KAY A;  1KHL A;  3NKR A;  4CYR A;  4MIV A;  1KHK A;  1E3C P;  5DLW A;  5EGH A;  4FDJ A;  4LRF A;  5IJQ A;  3DPC A;  1E1Z P;  3IGZ B;  2VQR A;  4LR7 A;  3SZY A;  1ALK A;  1O98 A;  2GLQ A;  3NKQ A;  3SZZ A;  1KHJ A;  5L0B A;  2W8D A;  4KAV A;  1KH5 A;  3MK2 A;  3UN3 A;  2QZU A;  3A52 A;  4NWX A;  2XR9 A;  3UO0 A;  3WAY A;  4CYS A;  4LR8 A;  2W5W A;  5GRR A;  1KH7 A;  1EW9 A;  4LRB A;  5L0K A;  4UPH A;  4QAX A;  1ANI A;  1ELX A;  4TN0 A;  4ZGA A;  2IFY A;  1ZED A;  1ED8 A;  3WAV A;  3TX0 A;  2RH6 A;  3M8Y A;  1O99 A;  2XRG A;  2W8S A;  3TWZ A;  2W5R A;  3BDG A;  2IUC B;  5TJ3 A;  4LRD A;  2ANH A;  4CXK A;  4MY4 A;  1HQA A;  3WBH A;  5L0E A;  4GTX A;  4GTY A;  1ELZ A;  3M7V A;  3ED4 A;  4GTZ A;  1K7H A;  3TG0 A;  4MHX A;  1AJA A;  5DLV A;  5DLT A;  3T02 A;  3BDG B;  4CXU A;  2IUC A;  2GSO A;  4CXS A;  1SHQ A;  1AJD A;  1B8J A;  1N2K A;  2GA3 A;  3NKN A;  1URA A;  1EQJ A;  4LR9 A;  5IJS A;  1URB A;  4KJG A;  4UPI A;  5AJ9 A;  3BDF A;  4N7T A;  3KD8 A;  1ZEF A;  3UNY A;  3E2D A;  1ALI A;  3UN2 A;  2GSU A;  1ZEB A;  3T00 A;  1HDH A; 
#chains in the Genus database with same CATH homology
 1AUK A;  4LR2 A;  5LQQ A;  5K4P A;  5EGE A;  1AJC A;  3M8Z A;  4UPL A;  1ANJ A;  3LXQ A;  1EJJ A;  3IDD A;  4LRE A;  1EW2 A;  4UOP A;  2W5V A;  1Y6V A;  4NWJ A;  2W5Q A;  4KJD A;  1KH4 A;  4UOO A;  5GOV A;  4FDI A;  2W5T A;  3T01 A;  5INH A;  3BDH A;  3NVL A;  4UOR A;  1ED9 A;  1E2S P;  4LRC A;  4UPK A;  1KH9 A;  2W5X A;  3MK0 A;  5KXA A;  1ELY A;  1N2L A;  4LQY A;  1EI6 A;  3NKP A;  2G9Y A;  5LIA A;  1EW8 A;  2GSN A;  2D1G A;  3DYC A;  1P49 A;  1E33 P;  3OT9 A;  4LRA A;  2X98 A;  3CMR A;  4GTW A;  4ZG6 A;  3WAW A;  5LRN A;  1Y7A A;  1AJB A;  3WAX A;  5HRT A;  3Q3Q A;  1ALH A;  4KM4 A;  4ZG7 A;  4YR1 A;  1HJK A;  3MK1 A;  3UN5 A;  1FSU A;  3NKM A;  3IGY B;  3NKO A;  3B5Q A;  4ZG9 A;  5C66 A;  2W5S A;  4B56 A;  2ZKT A;  5LRM A;  1KHN A;  1SHN A;  1ALJ A;  3M8W A;  4KAY A;  1KHL A;  3NKR A;  4CYR A;  4MIV A;  1KHK A;  1E3C P;  5DLW A;  5EGH A;  4FDJ A;  4LRF A;  5IJQ A;  3DPC A;  1E1Z P;  3IGZ B;  2VQR A;  4LR7 A;  3SZY A;  1ALK A;  1O98 A;  2GLQ A;  3NKQ A;  3SZZ A;  1KHJ A;  5L0B A;  2W8D A;  4KAV A;  1KH5 A;  3MK2 A;  3UN3 A;  2QZU A;  3A52 A;  4NWX A;  2XR9 A;  3UO0 A;  3WAY A;  4CYS A;  4LR8 A;  2W5W A;  5GRR A;  1KH7 A;  1EW9 A;  4LRB A;  5L0K A;  4UPH A;  4QAX A;  1ANI A;  1ELX A;  4TN0 A;  4ZGA A;  2IFY A;  1ZED A;  1ED8 A;  3WAV A;  3TX0 A;  2RH6 A;  3M8Y A;  1O99 A;  2XRG A;  2W8S A;  3TWZ A;  2W5R A;  3BDG A;  2IUC B;  5TJ3 A;  4LRD A;  2ANH A;  4CXK A;  4MY4 A;  1HQA A;  3WBH A;  5L0E A;  4GTX A;  4GTY A;  1ELZ A;  3M7V A;  3ED4 A;  4GTZ A;  1K7H A;  3TG0 A;  4MHX A;  1AJA A;  5DLV A;  5DLT A;  3T02 A;  3BDG B;  4CXU A;  2IUC A;  2GSO A;  4CXS A;  1SHQ A;  1AJD A;  1B8J A;  1N2K A;  2GA3 A;  3NKN A;  1URA A;  1EQJ A;  4LR9 A;  5IJS A;  1URB A;  4KJG A;  4UPI A;  5AJ9 A;  3BDF A;  4N7T A;  3KD8 A;  1ZEF A;  3UNY A;  3E2D A;  1ALI A;  3UN2 A;  2GSU A;  1ZEB A;  3T00 A;  1HDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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