3BDHA

Crystal structure of zinc-deficient wild-type e. coli alkaline phosphatase
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
total genus 154
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdhA00
5TJ3A 1N2KA 1HQAA 1ANJA 3M8WA 1EW2A 1ALIA 1FSUA 3MK0A 4LRFA 1B8JA 5IJQA 4GTXA 2W5QA 2RH6A 2GSOA 4KJGA 3TX0A 2D1GA 3WAVA 1KHNA 2XR9A 4LRCA 5EGEA 1ALKA 2W5SA 4LREA 4ZG7A 1URAA 1ZEFA 3M7VA 2IFYA 3MK2A 4FDIA 2W5RA 4UORA 3WBHA 1ED9A 2ANHA 4CXSA 2W8DA 1Y6VA 1AUKA 4LRAA 4TN0A 2GSUA 1KH5A 3NKPA 4ZGAA 3KD8A 5C66A 5DLVA 4YR1A 3TG0A 4LRDA 4CXKA 5AJ9A 4UOOA 2GLQA 4LR2A 1P49A 1K7HA 1E33P 4MHXA 4CXUA 5INHA 4NWJA 1ELXA 3BDGB 1Y7AA 2W5VA 4LR7A 1EJJA 4N7TA 1KH4A 2X98A 1E3CP 3IGZB 3Q3QA 5K4PA 5LRNA 1ELZA 5DLWA 5GRRA 5KXAA 2QZUA 2VQRA 2W5WA 1ED8A 1EW9A 3OT9A 1O99A 1ELYA 3UN5A 3T00A 3WAWA 1O98A 5L0EA 1ANIA 3ED4A 4ZG6A 1SHQA 3M8YA 3M8ZA 3BDHA 3UNYA 1E2SP 5HRTA 3NKOA 3T01A 5GOVA 4KJDA 2ZKTA 1SHNA 2GSNA 1URBA 4LR9A 3T02A 1AJBA 4KAVA 5L0KA 1N2LA 3BDFA 1KH7A 3A52A 1KHKA 4FDJA 3DPCA 2XRGA 1HDHA 3NKNA 1EW8A 1AJDA 2IUCB 4UOPA 2W8SA 3SZZA 4MY4A 4LR8A 4B56A 3SZYA 5L0BA 3TWZA 3BDGA 1KHJA 4GTYA 5LIAA 1HJKA 3LXQA 5LQQA 1KH9A 1ZEBA 3UN3A 1AJCA 5EGHA 4NWXA 3UN2A 3B5QA 2W5XA 2W5TA 4GTWA 1KHLA 1ALHA 1E1ZP 4KAYA 4MIVA 4LRBA 3NKQA 4KM4A 4GTZA 3NKMA 3IDDA 5DLTA 3E2DA 3IGYB 5LRMA 4LQYA 5IJSA 1EI6A 2G9YA 2GA3A 4CYRA 3MK1A 4UPKA 1ZEDA 1EQJA 4UPIA 3WAXA 3WAYA 4CYSA 3NKRA 3CMRA 4ZG9A 4UPLA 1ALJA 2IUCA 4UPHA 1AJAA 3NVLA 4QAXA 3UO0A 3DYCA
chains in the Genus database with same CATH superfamily
5TJ3A 1N2KA 1HQAA 1ANJA 3M8WA 1EW2A 1ALIA 1FSUA 3MK0A 4LRFA 1B8JA 5IJQA 4GTXA 2W5QA 2RH6A 2GSOA 4KJGA 3TX0A 2D1GA 3WAVA 1KHNA 2XR9A 4LRCA 5EGEA 1ALKA 2W5SA 4LREA 4ZG7A 1URAA 1ZEFA 3M7VA 2IFYA 3MK2A 4FDIA 2W5RA 4UORA 3WBHA 1ED9A 2ANHA 4CXSA 2W8DA 1Y6VA 1AUKA 4LRAA 4TN0A 2GSUA 1KH5A 3NKPA 4ZGAA 3KD8A 5C66A 5DLVA 4YR1A 3TG0A 4LRDA 4CXKA 5AJ9A 4UOOA 2GLQA 4LR2A 1P49A 1K7HA 1E33P 4MHXA 4CXUA 5INHA 4NWJA 1ELXA 3BDGB 1Y7AA 2W5VA 4LR7A 1EJJA 4N7TA 1KH4A 2X98A 1E3CP 3IGZB 3Q3QA 5K4PA 5LRNA 1ELZA 5DLWA 5GRRA 5KXAA 2QZUA 2VQRA 2W5WA 1ED8A 1EW9A 3OT9A 1O99A 1ELYA 3UN5A 3T00A 3WAWA 1O98A 5L0EA 1ANIA 3ED4A 4ZG6A 1SHQA 3M8YA 3M8ZA 3BDHA 3UNYA 1E2SP 5HRTA 3NKOA 3T01A 5GOVA 4KJDA 2ZKTA 1SHNA 2GSNA 1URBA 4LR9A 3T02A 1AJBA 4KAVA 5L0KA 1N2LA 3BDFA 1KH7A 3A52A 1KHKA 4FDJA 3DPCA 2XRGA 1HDHA 3NKNA 1EW8A 1AJDA 2IUCB 4UOPA 2W8SA 3SZZA 4MY4A 4LR8A 4B56A 3SZYA 5L0BA 3TWZA 3BDGA 1KHJA 4GTYA 5LIAA 1HJKA 3LXQA 5LQQA 1KH9A 1ZEBA 3UN3A 1AJCA 5EGHA 4NWXA 3UN2A 3B5QA 2W5XA 2W5TA 4GTWA 1KHLA 1ALHA 1E1ZP 4KAYA 4MIVA 4LRBA 3NKQA 4KM4A 4GTZA 3NKMA 3IDDA 5DLTA 3E2DA 3IGYB 5LRMA 4LQYA 5IJSA 1EI6A 2G9YA 2GA3A 4CYRA 3MK1A 4UPKA 1ZEDA 1EQJA 4UPIA 3WAXA 3WAYA 4CYSA 3NKRA 3CMRA 4ZG9A 4UPLA 1ALJA 2IUCA 4UPHA 1AJAA 3NVLA 4QAXA 3UO0A 3DYCA
chains in the Genus database with same CATH topology
5TJ3A 1N2KA 1HQAA 1ANJA 3M8WA 1EW2A 1ALIA 1FSUA 3MK0A 4LRFA 1B8JA 5IJQA 4GTXA 2W5QA 2RH6A 2GSOA 4KJGA 3TX0A 2D1GA 3WAVA 1KHNA 2XR9A 4LRCA 5EGEA 1ALKA 2W5SA 4LREA 4ZG7A 1URAA 1ZEFA 3M7VA 2IFYA 3MK2A 4FDIA 2W5RA 4UORA 3WBHA 1ED9A 2ANHA 4CXSA 2W8DA 1Y6VA 1AUKA 4LRAA 4TN0A 2GSUA 1KH5A 3NKPA 4ZGAA 3KD8A 5C66A 5DLVA 4YR1A 3TG0A 4LRDA 4CXKA 5AJ9A 4UOOA 2GLQA 4LR2A 1P49A 1K7HA 1E33P 4MHXA 4CXUA 5INHA 4NWJA 1ELXA 3BDGB 1Y7AA 2W5VA 4LR7A 1EJJA 4N7TA 1KH4A 2X98A 1E3CP 3IGZB 3Q3QA 5K4PA 5LRNA 1ELZA 5DLWA 5GRRA 5KXAA 2QZUA 2VQRA 2W5WA 1ED8A 1EW9A 3OT9A 1O99A 1ELYA 3UN5A 3T00A 3WAWA 1O98A 5L0EA 1ANIA 3ED4A 4ZG6A 1SHQA 3M8YA 3M8ZA 3BDHA 3UNYA 1E2SP 5HRTA 3NKOA 3T01A 5GOVA 4KJDA 2ZKTA 1SHNA 2GSNA 1URBA 4LR9A 3T02A 1AJBA 4KAVA 5L0KA 1N2LA 3BDFA 1KH7A 3A52A 1KHKA 4FDJA 3DPCA 2XRGA 1HDHA 3NKNA 1EW8A 1AJDA 2IUCB 4UOPA 2W8SA 3SZZA 4MY4A 4LR8A 4B56A 3SZYA 5L0BA 3TWZA 3BDGA 1KHJA 4GTYA 5LIAA 1HJKA 3LXQA 5LQQA 1KH9A 1ZEBA 3UN3A 1AJCA 5EGHA 4NWXA 3UN2A 3B5QA 2W5XA 2W5TA 4GTWA 1KHLA 1ALHA 1E1ZP 4KAYA 4MIVA 4LRBA 3NKQA 4KM4A 4GTZA 3NKMA 3IDDA 5DLTA 3E2DA 3IGYB 5LRMA 4LQYA 5IJSA 1EI6A 2G9YA 2GA3A 4CYRA 3MK1A 4UPKA 1ZEDA 1EQJA 4UPIA 3WAXA 3WAYA 4CYSA 3NKRA 3CMRA 4ZG9A 4UPLA 1ALJA 2IUCA 4UPHA 1AJAA 3NVLA 4QAXA 3UO0A 3DYCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5TJ3 A;  1N2K A;  1HQA A;  1ANJ A;  3M8W A;  1EW2 A;  1ALI A;  1FSU A;  3MK0 A;  4LRF A;  1B8J A;  5IJQ A;  4GTX A;  2W5Q A;  2RH6 A;  2GSO A;  4KJG A;  3TX0 A;  2D1G A;  3WAV A;  1KHN A;  2XR9 A;  4LRC A;  5EGE A;  1ALK A;  2W5S A;  4LRE A;  4ZG7 A;  1URA A;  1ZEF A;  3M7V A;  2IFY A;  3MK2 A;  4FDI A;  2W5R A;  4UOR A;  3WBH A;  1ED9 A;  2ANH A;  4CXS A;  2W8D A;  1Y6V A;  1AUK A;  4LRA A;  4TN0 A;  2GSU A;  1KH5 A;  3NKP A;  4ZGA A;  3KD8 A;  5C66 A;  5DLV A;  4YR1 A;  3TG0 A;  4LRD A;  4CXK A;  5AJ9 A;  4UOO A;  2GLQ A;  4LR2 A;  1P49 A;  1K7H A;  1E33 P;  4MHX A;  4CXU A;  5INH A;  4NWJ A;  1ELX A;  3BDG B;  1Y7A A;  2W5V A;  4LR7 A;  1EJJ A;  4N7T A;  1KH4 A;  2X98 A;  1E3C P;  3IGZ B;  3Q3Q A;  5K4P A;  5LRN A;  1ELZ A;  5DLW A;  5GRR A;  5KXA A;  2QZU A;  2VQR A;  2W5W A;  1ED8 A;  1EW9 A;  3OT9 A;  1O99 A;  1ELY A;  3UN5 A;  3T00 A;  3WAW A;  1O98 A;  5L0E A;  1ANI A;  3ED4 A;  4ZG6 A;  1SHQ A;  3M8Y A;  3M8Z A;  3BDH A;  3UNY A;  1E2S P;  5HRT A;  3NKO A;  3T01 A;  5GOV A;  4KJD A;  2ZKT A;  1SHN A;  2GSN A;  1URB A;  4LR9 A;  3T02 A;  1AJB A;  4KAV A;  5L0K A;  1N2L A;  3BDF A;  1KH7 A;  3A52 A;  1KHK A;  4FDJ A;  3DPC A;  2XRG A;  1HDH A;  3NKN A;  1EW8 A;  1AJD A;  2IUC B;  4UOP A;  2W8S A;  3SZZ A;  4MY4 A;  4LR8 A;  4B56 A;  3SZY A;  5L0B A;  3TWZ A;  3BDG A;  1KHJ A;  4GTY A;  5LIA A;  1HJK A;  3LXQ A;  5LQQ A;  1KH9 A;  1ZEB A;  3UN3 A;  1AJC A;  5EGH A;  4NWX A;  3UN2 A;  3B5Q A;  2W5X A;  2W5T A;  4GTW A;  1KHL A;  1ALH A;  1E1Z P;  4KAY A;  4MIV A;  4LRB A;  3NKQ A;  4KM4 A;  4GTZ A;  3NKM A;  3IDD A;  5DLT A;  3E2D A;  3IGY B;  5LRM A;  4LQY A;  5IJS A;  1EI6 A;  2G9Y A;  2GA3 A;  4CYR A;  3MK1 A;  4UPK A;  1ZED A;  1EQJ A;  4UPI A;  3WAX A;  3WAY A;  4CYS A;  3NKR A;  3CMR A;  4ZG9 A;  4UPL A;  1ALJ A;  2IUC A;  4UPH A;  1AJA A;  3NVL A;  4QAX A;  3UO0 A;  3DYC A; 
#chains in the Genus database with same CATH topology
 5TJ3 A;  1N2K A;  1HQA A;  1ANJ A;  3M8W A;  1EW2 A;  1ALI A;  1FSU A;  3MK0 A;  4LRF A;  1B8J A;  5IJQ A;  4GTX A;  2W5Q A;  2RH6 A;  2GSO A;  4KJG A;  3TX0 A;  2D1G A;  3WAV A;  1KHN A;  2XR9 A;  4LRC A;  5EGE A;  1ALK A;  2W5S A;  4LRE A;  4ZG7 A;  1URA A;  1ZEF A;  3M7V A;  2IFY A;  3MK2 A;  4FDI A;  2W5R A;  4UOR A;  3WBH A;  1ED9 A;  2ANH A;  4CXS A;  2W8D A;  1Y6V A;  1AUK A;  4LRA A;  4TN0 A;  2GSU A;  1KH5 A;  3NKP A;  4ZGA A;  3KD8 A;  5C66 A;  5DLV A;  4YR1 A;  3TG0 A;  4LRD A;  4CXK A;  5AJ9 A;  4UOO A;  2GLQ A;  4LR2 A;  1P49 A;  1K7H A;  1E33 P;  4MHX A;  4CXU A;  5INH A;  4NWJ A;  1ELX A;  3BDG B;  1Y7A A;  2W5V A;  4LR7 A;  1EJJ A;  4N7T A;  1KH4 A;  2X98 A;  1E3C P;  3IGZ B;  3Q3Q A;  5K4P A;  5LRN A;  1ELZ A;  5DLW A;  5GRR A;  5KXA A;  2QZU A;  2VQR A;  2W5W A;  1ED8 A;  1EW9 A;  3OT9 A;  1O99 A;  1ELY A;  3UN5 A;  3T00 A;  3WAW A;  1O98 A;  5L0E A;  1ANI A;  3ED4 A;  4ZG6 A;  1SHQ A;  3M8Y A;  3M8Z A;  3BDH A;  3UNY A;  1E2S P;  5HRT A;  3NKO A;  3T01 A;  5GOV A;  4KJD A;  2ZKT A;  1SHN A;  2GSN A;  1URB A;  4LR9 A;  3T02 A;  1AJB A;  4KAV A;  5L0K A;  1N2L A;  3BDF A;  1KH7 A;  3A52 A;  1KHK A;  4FDJ A;  3DPC A;  2XRG A;  1HDH A;  3NKN A;  1EW8 A;  1AJD A;  2IUC B;  4UOP A;  2W8S A;  3SZZ A;  4MY4 A;  4LR8 A;  4B56 A;  3SZY A;  5L0B A;  3TWZ A;  3BDG A;  1KHJ A;  4GTY A;  5LIA A;  1HJK A;  3LXQ A;  5LQQ A;  1KH9 A;  1ZEB A;  3UN3 A;  1AJC A;  5EGH A;  4NWX A;  3UN2 A;  3B5Q A;  2W5X A;  2W5T A;  4GTW A;  1KHL A;  1ALH A;  1E1Z P;  4KAY A;  4MIV A;  4LRB A;  3NKQ A;  4KM4 A;  4GTZ A;  3NKM A;  3IDD A;  5DLT A;  3E2D A;  3IGY B;  5LRM A;  4LQY A;  5IJS A;  1EI6 A;  2G9Y A;  2GA3 A;  4CYR A;  3MK1 A;  4UPK A;  1ZED A;  1EQJ A;  4UPI A;  3WAX A;  3WAY A;  4CYS A;  3NKR A;  3CMR A;  4ZG9 A;  4UPL A;  1ALJ A;  2IUC A;  4UPH A;  1AJA A;  3NVL A;  4QAX A;  3UO0 A;  3DYC A; 
#chains in the Genus database with same CATH homology
 5TJ3 A;  1N2K A;  1HQA A;  1ANJ A;  3M8W A;  1EW2 A;  1ALI A;  1FSU A;  3MK0 A;  4LRF A;  1B8J A;  5IJQ A;  4GTX A;  2W5Q A;  2RH6 A;  2GSO A;  4KJG A;  3TX0 A;  2D1G A;  3WAV A;  1KHN A;  2XR9 A;  4LRC A;  5EGE A;  1ALK A;  2W5S A;  4LRE A;  4ZG7 A;  1URA A;  1ZEF A;  3M7V A;  2IFY A;  3MK2 A;  4FDI A;  2W5R A;  4UOR A;  3WBH A;  1ED9 A;  2ANH A;  4CXS A;  2W8D A;  1Y6V A;  1AUK A;  4LRA A;  4TN0 A;  2GSU A;  1KH5 A;  3NKP A;  4ZGA A;  3KD8 A;  5C66 A;  5DLV A;  4YR1 A;  3TG0 A;  4LRD A;  4CXK A;  5AJ9 A;  4UOO A;  2GLQ A;  4LR2 A;  1P49 A;  1K7H A;  1E33 P;  4MHX A;  4CXU A;  5INH A;  4NWJ A;  1ELX A;  3BDG B;  1Y7A A;  2W5V A;  4LR7 A;  1EJJ A;  4N7T A;  1KH4 A;  2X98 A;  1E3C P;  3IGZ B;  3Q3Q A;  5K4P A;  5LRN A;  1ELZ A;  5DLW A;  5GRR A;  5KXA A;  2QZU A;  2VQR A;  2W5W A;  1ED8 A;  1EW9 A;  3OT9 A;  1O99 A;  1ELY A;  3UN5 A;  3T00 A;  3WAW A;  1O98 A;  5L0E A;  1ANI A;  3ED4 A;  4ZG6 A;  1SHQ A;  3M8Y A;  3M8Z A;  3BDH A;  3UNY A;  1E2S P;  5HRT A;  3NKO A;  3T01 A;  5GOV A;  4KJD A;  2ZKT A;  1SHN A;  2GSN A;  1URB A;  4LR9 A;  3T02 A;  1AJB A;  4KAV A;  5L0K A;  1N2L A;  3BDF A;  1KH7 A;  3A52 A;  1KHK A;  4FDJ A;  3DPC A;  2XRG A;  1HDH A;  3NKN A;  1EW8 A;  1AJD A;  2IUC B;  4UOP A;  2W8S A;  3SZZ A;  4MY4 A;  4LR8 A;  4B56 A;  3SZY A;  5L0B A;  3TWZ A;  3BDG A;  1KHJ A;  4GTY A;  5LIA A;  1HJK A;  3LXQ A;  5LQQ A;  1KH9 A;  1ZEB A;  3UN3 A;  1AJC A;  5EGH A;  4NWX A;  3UN2 A;  3B5Q A;  2W5X A;  2W5T A;  4GTW A;  1KHL A;  1ALH A;  1E1Z P;  4KAY A;  4MIV A;  4LRB A;  3NKQ A;  4KM4 A;  4GTZ A;  3NKM A;  3IDD A;  5DLT A;  3E2D A;  3IGY B;  5LRM A;  4LQY A;  5IJS A;  1EI6 A;  2G9Y A;  2GA3 A;  4CYR A;  3MK1 A;  4UPK A;  1ZED A;  1EQJ A;  4UPI A;  3WAX A;  3WAY A;  4CYS A;  3NKR A;  3CMR A;  4ZG9 A;  4UPL A;  1ALJ A;  2IUC A;  4UPH A;  1AJA A;  3NVL A;  4QAX A;  3UO0 A;  3DYC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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