3BDHA

Crystal structure of zinc-deficient wild-type e. coli alkaline phosphatase
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Alkaline phosphatase
total genus 154
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdhA00
4ZG9A 5EGEA 1N2KA 3ED4A 4NWXA 4UPKA 3UNYA 4LR7A 5AJ9A 1ED9A 3E2DA 3WAYA 4NWJA 3TX0A 5HRTA 2XR9A 2D1GA 4LREA 5GRRA 4KJGA 5L0KA 4LRDA 1ED8A 2W5VA 4LRBA 1HJKA 1AJDA 1Y7AA 1Y6VA 2IUCA 4CXUA 5LIAA 1KH4A 5IJQA 1KH9A 5GOVA 3LXQA 3M8ZA 3SZZA 3NKRA 4KJDA 2IFYA 1ALHA 2QZUA 1AUKA 3NKNA 4UOOA 1KHJA 4KM4A 1KHNA 4LRAA 2W8DA 4QAXA 1ELYA 1SHNA 3IGYB 4KAVA 4UORA 3UN3A 4B56A 2XRGA 4GTZA 1ALJA 1E33P 1EQJA 2RH6A 5EGHA 3WBHA 3UN5A 1O99A 1ELZA 1ALIA 4MY4A 4ZG6A 1SHQA 4KAYA 3T02A 4ZGAA 1K7HA 1FSUA 5KXAA 3WAWA 3Q3QA 2IUCB 5LRNA 1KHKA 2GSOA 3CMRA 2W5SA 5DLVA 4N7TA 4LRCA 2W5WA 3M8YA 1EJJA 1N2LA 5INHA 5IJSA 4UPIA 1E1ZP 1EI6A 1B8JA 4LRFA 2W5TA 1ALKA 3BDGA 4CXKA 3NKPA 4FDIA 3UO0A 3MK0A 4YR1A 1EW9A 5LQQA 1ZEFA 2W5RA 3WAVA 3A52A 4GTYA 4LR9A 1HQAA 5TJ3A 1KH7A 1E2SP 2GA3A 4LQYA 4UPLA 2GSNA 5LRMA 4CXSA 4LR2A 1URAA 2ZKTA 3SZYA 4TN0A 1EW8A 1EW2A 2W8SA 4CYRA 1ANIA 5L0BA 1ELXA 2W5QA 5DLTA 3TG0A 3B5QA 3WAXA 3NKMA 2VQRA 3BDFA 2ANHA 4LR8A 1HDHA 5C66A 4GTWA 2GSUA 4CYSA 3BDHA 3MK1A 1O98A 3NKOA 5DLWA 3KD8A 1AJAA 3IGZB 4FDJA 5L0EA 1KHLA 3DYCA 4MIVA 4UOPA 2G9YA 3M7VA 1AJCA 3OT9A 4GTXA 3T00A 4MHXA 1E3CP 4ZG7A 3DPCA 1URBA 1ANJA 1ZEDA 3TWZA 1ZEBA 3MK2A 5K4PA 2X98A 1AJBA 3NVLA 1P49A 3T01A 3UN2A 3IDDA 1KH5A 3M8WA 3NKQA 4UPHA 2GLQA 2W5XA 3BDGB
chains in the Genus database with same CATH superfamily
4ZG9A 5EGEA 1N2KA 3ED4A 4NWXA 4UPKA 3UNYA 4LR7A 5AJ9A 1ED9A 3E2DA 3WAYA 4NWJA 3TX0A 5HRTA 2XR9A 2D1GA 4LREA 5GRRA 4KJGA 5L0KA 4LRDA 1ED8A 2W5VA 4LRBA 1HJKA 1AJDA 1Y7AA 1Y6VA 2IUCA 4CXUA 5LIAA 1KH4A 5IJQA 1KH9A 5GOVA 3LXQA 3M8ZA 3SZZA 3NKRA 4KJDA 2IFYA 1ALHA 2QZUA 1AUKA 3NKNA 4UOOA 1KHJA 4KM4A 1KHNA 4LRAA 2W8DA 4QAXA 1ELYA 1SHNA 3IGYB 4KAVA 4UORA 3UN3A 4B56A 2XRGA 4GTZA 1ALJA 1E33P 1EQJA 2RH6A 5EGHA 3WBHA 3UN5A 1O99A 1ELZA 1ALIA 4MY4A 4ZG6A 1SHQA 4KAYA 3T02A 4ZGAA 1K7HA 1FSUA 5KXAA 3WAWA 3Q3QA 2IUCB 5LRNA 1KHKA 2GSOA 3CMRA 2W5SA 5DLVA 4N7TA 4LRCA 2W5WA 3M8YA 1EJJA 1N2LA 5INHA 5IJSA 4UPIA 1E1ZP 1EI6A 1B8JA 4LRFA 2W5TA 1ALKA 3BDGA 4CXKA 3NKPA 4FDIA 3UO0A 3MK0A 4YR1A 1EW9A 5LQQA 1ZEFA 2W5RA 3WAVA 3A52A 4GTYA 4LR9A 1HQAA 5TJ3A 1KH7A 1E2SP 2GA3A 4LQYA 4UPLA 2GSNA 5LRMA 4CXSA 4LR2A 1URAA 2ZKTA 3SZYA 4TN0A 1EW8A 1EW2A 2W8SA 4CYRA 1ANIA 5L0BA 1ELXA 2W5QA 5DLTA 3TG0A 3B5QA 3WAXA 3NKMA 2VQRA 3BDFA 2ANHA 4LR8A 1HDHA 5C66A 4GTWA 2GSUA 4CYSA 3BDHA 3MK1A 1O98A 3NKOA 5DLWA 3KD8A 1AJAA 3IGZB 4FDJA 5L0EA 1KHLA 3DYCA 4MIVA 4UOPA 2G9YA 3M7VA 1AJCA 3OT9A 4GTXA 3T00A 4MHXA 1E3CP 4ZG7A 3DPCA 1URBA 1ANJA 1ZEDA 3TWZA 1ZEBA 3MK2A 5K4PA 2X98A 1AJBA 3NVLA 1P49A 3T01A 3UN2A 3IDDA 1KH5A 3M8WA 3NKQA 4UPHA 2GLQA 2W5XA 3BDGB
chains in the Genus database with same CATH topology
4ZG9A 5EGEA 1N2KA 3ED4A 4NWXA 4UPKA 3UNYA 4LR7A 5AJ9A 1ED9A 3E2DA 3WAYA 4NWJA 3TX0A 5HRTA 2XR9A 2D1GA 4LREA 5GRRA 4KJGA 5L0KA 4LRDA 1ED8A 2W5VA 4LRBA 1HJKA 1AJDA 1Y7AA 1Y6VA 2IUCA 4CXUA 5LIAA 1KH4A 5IJQA 1KH9A 5GOVA 3LXQA 3M8ZA 3SZZA 3NKRA 4KJDA 2IFYA 1ALHA 2QZUA 1AUKA 3NKNA 4UOOA 1KHJA 4KM4A 1KHNA 4LRAA 2W8DA 4QAXA 1ELYA 1SHNA 3IGYB 4KAVA 4UORA 3UN3A 4B56A 2XRGA 4GTZA 1ALJA 1E33P 1EQJA 2RH6A 5EGHA 3WBHA 3UN5A 1O99A 1ELZA 1ALIA 4MY4A 4ZG6A 1SHQA 4KAYA 3T02A 4ZGAA 1K7HA 1FSUA 5KXAA 3WAWA 3Q3QA 2IUCB 5LRNA 1KHKA 2GSOA 3CMRA 2W5SA 5DLVA 4N7TA 4LRCA 2W5WA 3M8YA 1EJJA 1N2LA 5INHA 5IJSA 4UPIA 1E1ZP 1EI6A 1B8JA 4LRFA 2W5TA 1ALKA 3BDGA 4CXKA 3NKPA 4FDIA 3UO0A 3MK0A 4YR1A 1EW9A 5LQQA 1ZEFA 2W5RA 3WAVA 3A52A 4GTYA 4LR9A 1HQAA 5TJ3A 1KH7A 1E2SP 2GA3A 4LQYA 4UPLA 2GSNA 5LRMA 4CXSA 4LR2A 1URAA 2ZKTA 3SZYA 4TN0A 1EW8A 1EW2A 2W8SA 4CYRA 1ANIA 5L0BA 1ELXA 2W5QA 5DLTA 3TG0A 3B5QA 3WAXA 3NKMA 2VQRA 3BDFA 2ANHA 4LR8A 1HDHA 5C66A 4GTWA 2GSUA 4CYSA 3BDHA 3MK1A 1O98A 3NKOA 5DLWA 3KD8A 1AJAA 3IGZB 4FDJA 5L0EA 1KHLA 3DYCA 4MIVA 4UOPA 2G9YA 3M7VA 1AJCA 3OT9A 4GTXA 3T00A 4MHXA 1E3CP 4ZG7A 3DPCA 1URBA 1ANJA 1ZEDA 3TWZA 1ZEBA 3MK2A 5K4PA 2X98A 1AJBA 3NVLA 1P49A 3T01A 3UN2A 3IDDA 1KH5A 3M8WA 3NKQA 4UPHA 2GLQA 2W5XA 3BDGB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZG9 A;  5EGE A;  1N2K A;  3ED4 A;  4NWX A;  4UPK A;  3UNY A;  4LR7 A;  5AJ9 A;  1ED9 A;  3E2D A;  3WAY A;  4NWJ A;  3TX0 A;  5HRT A;  2XR9 A;  2D1G A;  4LRE A;  5GRR A;  4KJG A;  5L0K A;  4LRD A;  1ED8 A;  2W5V A;  4LRB A;  1HJK A;  1AJD A;  1Y7A A;  1Y6V A;  2IUC A;  4CXU A;  5LIA A;  1KH4 A;  5IJQ A;  1KH9 A;  5GOV A;  3LXQ A;  3M8Z A;  3SZZ A;  3NKR A;  4KJD A;  2IFY A;  1ALH A;  2QZU A;  1AUK A;  3NKN A;  4UOO A;  1KHJ A;  4KM4 A;  1KHN A;  4LRA A;  2W8D A;  4QAX A;  1ELY A;  1SHN A;  3IGY B;  4KAV A;  4UOR A;  3UN3 A;  4B56 A;  2XRG A;  4GTZ A;  1ALJ A;  1E33 P;  1EQJ A;  2RH6 A;  5EGH A;  3WBH A;  3UN5 A;  1O99 A;  1ELZ A;  1ALI A;  4MY4 A;  4ZG6 A;  1SHQ A;  4KAY A;  3T02 A;  4ZGA A;  1K7H A;  1FSU A;  5KXA A;  3WAW A;  3Q3Q A;  2IUC B;  5LRN A;  1KHK A;  2GSO A;  3CMR A;  2W5S A;  5DLV A;  4N7T A;  4LRC A;  2W5W A;  3M8Y A;  1EJJ A;  1N2L A;  5INH A;  5IJS A;  4UPI A;  1E1Z P;  1EI6 A;  1B8J A;  4LRF A;  2W5T A;  1ALK A;  3BDG A;  4CXK A;  3NKP A;  4FDI A;  3UO0 A;  3MK0 A;  4YR1 A;  1EW9 A;  5LQQ A;  1ZEF A;  2W5R A;  3WAV A;  3A52 A;  4GTY A;  4LR9 A;  1HQA A;  5TJ3 A;  1KH7 A;  1E2S P;  2GA3 A;  4LQY A;  4UPL A;  2GSN A;  5LRM A;  4CXS A;  4LR2 A;  1URA A;  2ZKT A;  3SZY A;  4TN0 A;  1EW8 A;  1EW2 A;  2W8S A;  4CYR A;  1ANI A;  5L0B A;  1ELX A;  2W5Q A;  5DLT A;  3TG0 A;  3B5Q A;  3WAX A;  3NKM A;  2VQR A;  3BDF A;  2ANH A;  4LR8 A;  1HDH A;  5C66 A;  4GTW A;  2GSU A;  4CYS A;  3BDH A;  3MK1 A;  1O98 A;  3NKO A;  5DLW A;  3KD8 A;  1AJA A;  3IGZ B;  4FDJ A;  5L0E A;  1KHL A;  3DYC A;  4MIV A;  4UOP A;  2G9Y A;  3M7V A;  1AJC A;  3OT9 A;  4GTX A;  3T00 A;  4MHX A;  1E3C P;  4ZG7 A;  3DPC A;  1URB A;  1ANJ A;  1ZED A;  3TWZ A;  1ZEB A;  3MK2 A;  5K4P A;  2X98 A;  1AJB A;  3NVL A;  1P49 A;  3T01 A;  3UN2 A;  3IDD A;  1KH5 A;  3M8W A;  3NKQ A;  4UPH A;  2GLQ A;  2W5X A;  3BDG B; 
#chains in the Genus database with same CATH topology
 4ZG9 A;  5EGE A;  1N2K A;  3ED4 A;  4NWX A;  4UPK A;  3UNY A;  4LR7 A;  5AJ9 A;  1ED9 A;  3E2D A;  3WAY A;  4NWJ A;  3TX0 A;  5HRT A;  2XR9 A;  2D1G A;  4LRE A;  5GRR A;  4KJG A;  5L0K A;  4LRD A;  1ED8 A;  2W5V A;  4LRB A;  1HJK A;  1AJD A;  1Y7A A;  1Y6V A;  2IUC A;  4CXU A;  5LIA A;  1KH4 A;  5IJQ A;  1KH9 A;  5GOV A;  3LXQ A;  3M8Z A;  3SZZ A;  3NKR A;  4KJD A;  2IFY A;  1ALH A;  2QZU A;  1AUK A;  3NKN A;  4UOO A;  1KHJ A;  4KM4 A;  1KHN A;  4LRA A;  2W8D A;  4QAX A;  1ELY A;  1SHN A;  3IGY B;  4KAV A;  4UOR A;  3UN3 A;  4B56 A;  2XRG A;  4GTZ A;  1ALJ A;  1E33 P;  1EQJ A;  2RH6 A;  5EGH A;  3WBH A;  3UN5 A;  1O99 A;  1ELZ A;  1ALI A;  4MY4 A;  4ZG6 A;  1SHQ A;  4KAY A;  3T02 A;  4ZGA A;  1K7H A;  1FSU A;  5KXA A;  3WAW A;  3Q3Q A;  2IUC B;  5LRN A;  1KHK A;  2GSO A;  3CMR A;  2W5S A;  5DLV A;  4N7T A;  4LRC A;  2W5W A;  3M8Y A;  1EJJ A;  1N2L A;  5INH A;  5IJS A;  4UPI A;  1E1Z P;  1EI6 A;  1B8J A;  4LRF A;  2W5T A;  1ALK A;  3BDG A;  4CXK A;  3NKP A;  4FDI A;  3UO0 A;  3MK0 A;  4YR1 A;  1EW9 A;  5LQQ A;  1ZEF A;  2W5R A;  3WAV A;  3A52 A;  4GTY A;  4LR9 A;  1HQA A;  5TJ3 A;  1KH7 A;  1E2S P;  2GA3 A;  4LQY A;  4UPL A;  2GSN A;  5LRM A;  4CXS A;  4LR2 A;  1URA A;  2ZKT A;  3SZY A;  4TN0 A;  1EW8 A;  1EW2 A;  2W8S A;  4CYR A;  1ANI A;  5L0B A;  1ELX A;  2W5Q A;  5DLT A;  3TG0 A;  3B5Q A;  3WAX A;  3NKM A;  2VQR A;  3BDF A;  2ANH A;  4LR8 A;  1HDH A;  5C66 A;  4GTW A;  2GSU A;  4CYS A;  3BDH A;  3MK1 A;  1O98 A;  3NKO A;  5DLW A;  3KD8 A;  1AJA A;  3IGZ B;  4FDJ A;  5L0E A;  1KHL A;  3DYC A;  4MIV A;  4UOP A;  2G9Y A;  3M7V A;  1AJC A;  3OT9 A;  4GTX A;  3T00 A;  4MHX A;  1E3C P;  4ZG7 A;  3DPC A;  1URB A;  1ANJ A;  1ZED A;  3TWZ A;  1ZEB A;  3MK2 A;  5K4P A;  2X98 A;  1AJB A;  3NVL A;  1P49 A;  3T01 A;  3UN2 A;  3IDD A;  1KH5 A;  3M8W A;  3NKQ A;  4UPH A;  2GLQ A;  2W5X A;  3BDG B; 
#chains in the Genus database with same CATH homology
 4ZG9 A;  5EGE A;  1N2K A;  3ED4 A;  4NWX A;  4UPK A;  3UNY A;  4LR7 A;  5AJ9 A;  1ED9 A;  3E2D A;  3WAY A;  4NWJ A;  3TX0 A;  5HRT A;  2XR9 A;  2D1G A;  4LRE A;  5GRR A;  4KJG A;  5L0K A;  4LRD A;  1ED8 A;  2W5V A;  4LRB A;  1HJK A;  1AJD A;  1Y7A A;  1Y6V A;  2IUC A;  4CXU A;  5LIA A;  1KH4 A;  5IJQ A;  1KH9 A;  5GOV A;  3LXQ A;  3M8Z A;  3SZZ A;  3NKR A;  4KJD A;  2IFY A;  1ALH A;  2QZU A;  1AUK A;  3NKN A;  4UOO A;  1KHJ A;  4KM4 A;  1KHN A;  4LRA A;  2W8D A;  4QAX A;  1ELY A;  1SHN A;  3IGY B;  4KAV A;  4UOR A;  3UN3 A;  4B56 A;  2XRG A;  4GTZ A;  1ALJ A;  1E33 P;  1EQJ A;  2RH6 A;  5EGH A;  3WBH A;  3UN5 A;  1O99 A;  1ELZ A;  1ALI A;  4MY4 A;  4ZG6 A;  1SHQ A;  4KAY A;  3T02 A;  4ZGA A;  1K7H A;  1FSU A;  5KXA A;  3WAW A;  3Q3Q A;  2IUC B;  5LRN A;  1KHK A;  2GSO A;  3CMR A;  2W5S A;  5DLV A;  4N7T A;  4LRC A;  2W5W A;  3M8Y A;  1EJJ A;  1N2L A;  5INH A;  5IJS A;  4UPI A;  1E1Z P;  1EI6 A;  1B8J A;  4LRF A;  2W5T A;  1ALK A;  3BDG A;  4CXK A;  3NKP A;  4FDI A;  3UO0 A;  3MK0 A;  4YR1 A;  1EW9 A;  5LQQ A;  1ZEF A;  2W5R A;  3WAV A;  3A52 A;  4GTY A;  4LR9 A;  1HQA A;  5TJ3 A;  1KH7 A;  1E2S P;  2GA3 A;  4LQY A;  4UPL A;  2GSN A;  5LRM A;  4CXS A;  4LR2 A;  1URA A;  2ZKT A;  3SZY A;  4TN0 A;  1EW8 A;  1EW2 A;  2W8S A;  4CYR A;  1ANI A;  5L0B A;  1ELX A;  2W5Q A;  5DLT A;  3TG0 A;  3B5Q A;  3WAX A;  3NKM A;  2VQR A;  3BDF A;  2ANH A;  4LR8 A;  1HDH A;  5C66 A;  4GTW A;  2GSU A;  4CYS A;  3BDH A;  3MK1 A;  1O98 A;  3NKO A;  5DLW A;  3KD8 A;  1AJA A;  3IGZ B;  4FDJ A;  5L0E A;  1KHL A;  3DYC A;  4MIV A;  4UOP A;  2G9Y A;  3M7V A;  1AJC A;  3OT9 A;  4GTX A;  3T00 A;  4MHX A;  1E3C P;  4ZG7 A;  3DPC A;  1URB A;  1ANJ A;  1ZED A;  3TWZ A;  1ZEB A;  3MK2 A;  5K4P A;  2X98 A;  1AJB A;  3NVL A;  1P49 A;  3T01 A;  3UN2 A;  3IDD A;  1KH5 A;  3M8W A;  3NKQ A;  4UPH A;  2GLQ A;  2W5X A;  3BDG B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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