3BDHA

Crystal structure of zinc-deficient wild-type e. coli alkaline phosphatase
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 154
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdhA00
2W8DA 1KHLA 4CXSA 3MK0A 2G9YA 4GTXA 3NKNA 5GOVA 4GTZA 3M7VA 4MY4A 1EW2A 5LRMA 1EI6A 1URBA 3M8WA 4ZG7A 1N2LA 1ED8A 1KHJA 1ELYA 3LXQA 3M8YA 4LRCA 2ZKTA 4LRFA 1ANIA 4LREA 2XRGA 2VQRA 4KAVA 3OT9A 2W5QA 3WAWA 4TN0A 4LR2A 5EGEA 5DLVA 1ELXA 3E2DA 3IGZB 4GTWA 1FSUA 5AJ9A 3TX0A 2IFYA 4B56A 2X98A 1ED9A 4LRBA 3IGYB 5L0KA 2W5TA 1O98A 3UNYA 4GTYA 4UPIA 1KH7A 5KXAA 1AJDA 4N7TA 2GSUA 4NWXA 1ANJA 1HQAA 3NKRA 4CXUA 1Y7AA 3BDGB 1ALHA 1ZEBA 5L0BA 2XR9A 1K7HA 1E2SP 1ZEDA 3NKOA 2GSOA 4UOOA 1AJAA 3Q3QA 3T01A 4FDIA 2GSNA 3NKQA 3CMRA 3MK2A 1B8JA 3NVLA 5DLTA 3UO0A 3B5QA 1E33P 5IJQA 1KHNA 4LRDA 2W5XA 1HJKA 4QAXA 5TJ3A 3NKPA 5C66A 3WAXA 5L0EA 3NKMA 2GA3A 4FDJA 2IUCB 4ZG6A 5LRNA 3TG0A 3MK1A 3IDDA 5IJSA 5LIAA 1ALJA 1O99A 2GLQA 1KH9A 4MIVA 3WBHA 1KH4A 1KHKA 5LQQA 1Y6VA 1ELZA 1E3CP 4KAYA 2W5RA 4UPHA 4LRAA 1E1ZP 1EJJA 1ALIA 1EW9A 3BDFA 5INHA 3BDHA 3SZYA 4ZGAA 1SHQA 1URAA 2QZUA 2ANHA 3WAVA 3DYCA 1AJBA 4LR8A 3WAYA 4CXKA 3UN3A 3A52A 4ZG9A 4MHXA 3DPCA 5HRTA 2IUCA 3T02A 3T00A 4KJDA 4CYSA 1SHNA 4CYRA 3TWZA 3UN5A 1ALKA 4KJGA 4UOPA 4LR9A 3BDGA 5GRRA 1EQJA 1KH5A 2RH6A 5K4PA 2W8SA 4UPKA 4YR1A 2D1GA 4LR7A 1AUKA 3UN2A 1P49A 3ED4A 4LQYA 1AJCA 1N2KA 3M8ZA 3KD8A 1EW8A 4NWJA 1ZEFA 4KM4A 4UORA 2W5VA 5DLWA 2W5SA 3SZZA 4UPLA 2W5WA 1HDHA 5EGHA
chains in the Genus database with same CATH superfamily
2W8DA 1KHLA 4CXSA 3MK0A 2G9YA 4GTXA 3NKNA 5GOVA 4GTZA 3M7VA 4MY4A 1EW2A 5LRMA 1EI6A 1URBA 3M8WA 4ZG7A 1N2LA 1ED8A 1KHJA 1ELYA 3LXQA 3M8YA 4LRCA 2ZKTA 4LRFA 1ANIA 4LREA 2XRGA 2VQRA 4KAVA 3OT9A 2W5QA 3WAWA 4TN0A 4LR2A 5EGEA 5DLVA 1ELXA 3E2DA 3IGZB 4GTWA 1FSUA 5AJ9A 3TX0A 2IFYA 4B56A 2X98A 1ED9A 4LRBA 3IGYB 5L0KA 2W5TA 1O98A 3UNYA 4GTYA 4UPIA 1KH7A 5KXAA 1AJDA 4N7TA 2GSUA 4NWXA 1ANJA 1HQAA 3NKRA 4CXUA 1Y7AA 3BDGB 1ALHA 1ZEBA 5L0BA 2XR9A 1K7HA 1E2SP 1ZEDA 3NKOA 2GSOA 4UOOA 1AJAA 3Q3QA 3T01A 4FDIA 2GSNA 3NKQA 3CMRA 3MK2A 1B8JA 3NVLA 5DLTA 3UO0A 3B5QA 1E33P 5IJQA 1KHNA 4LRDA 2W5XA 1HJKA 4QAXA 5TJ3A 3NKPA 5C66A 3WAXA 5L0EA 3NKMA 2GA3A 4FDJA 2IUCB 4ZG6A 5LRNA 3TG0A 3MK1A 3IDDA 5IJSA 5LIAA 1ALJA 1O99A 2GLQA 1KH9A 4MIVA 3WBHA 1KH4A 1KHKA 5LQQA 1Y6VA 1ELZA 1E3CP 4KAYA 2W5RA 4UPHA 4LRAA 1E1ZP 1EJJA 1ALIA 1EW9A 3BDFA 5INHA 3BDHA 3SZYA 4ZGAA 1SHQA 1URAA 2QZUA 2ANHA 3WAVA 3DYCA 1AJBA 4LR8A 3WAYA 4CXKA 3UN3A 3A52A 4ZG9A 4MHXA 3DPCA 5HRTA 2IUCA 3T02A 3T00A 4KJDA 4CYSA 1SHNA 4CYRA 3TWZA 3UN5A 1ALKA 4KJGA 4UOPA 4LR9A 3BDGA 5GRRA 1EQJA 1KH5A 2RH6A 5K4PA 2W8SA 4UPKA 4YR1A 2D1GA 4LR7A 1AUKA 3UN2A 1P49A 3ED4A 4LQYA 1AJCA 1N2KA 3M8ZA 3KD8A 1EW8A 4NWJA 1ZEFA 4KM4A 4UORA 2W5VA 5DLWA 2W5SA 3SZZA 4UPLA 2W5WA 1HDHA 5EGHA
chains in the Genus database with same CATH topology
2W8DA 1KHLA 4CXSA 3MK0A 2G9YA 4GTXA 3NKNA 5GOVA 4GTZA 3M7VA 4MY4A 1EW2A 5LRMA 1EI6A 1URBA 3M8WA 4ZG7A 1N2LA 1ED8A 1KHJA 1ELYA 3LXQA 3M8YA 4LRCA 2ZKTA 4LRFA 1ANIA 4LREA 2XRGA 2VQRA 4KAVA 3OT9A 2W5QA 3WAWA 4TN0A 4LR2A 5EGEA 5DLVA 1ELXA 3E2DA 3IGZB 4GTWA 1FSUA 5AJ9A 3TX0A 2IFYA 4B56A 2X98A 1ED9A 4LRBA 3IGYB 5L0KA 2W5TA 1O98A 3UNYA 4GTYA 4UPIA 1KH7A 5KXAA 1AJDA 4N7TA 2GSUA 4NWXA 1ANJA 1HQAA 3NKRA 4CXUA 1Y7AA 3BDGB 1ALHA 1ZEBA 5L0BA 2XR9A 1K7HA 1E2SP 1ZEDA 3NKOA 2GSOA 4UOOA 1AJAA 3Q3QA 3T01A 4FDIA 2GSNA 3NKQA 3CMRA 3MK2A 1B8JA 3NVLA 5DLTA 3UO0A 3B5QA 1E33P 5IJQA 1KHNA 4LRDA 2W5XA 1HJKA 4QAXA 5TJ3A 3NKPA 5C66A 3WAXA 5L0EA 3NKMA 2GA3A 4FDJA 2IUCB 4ZG6A 5LRNA 3TG0A 3MK1A 3IDDA 5IJSA 5LIAA 1ALJA 1O99A 2GLQA 1KH9A 4MIVA 3WBHA 1KH4A 1KHKA 5LQQA 1Y6VA 1ELZA 1E3CP 4KAYA 2W5RA 4UPHA 4LRAA 1E1ZP 1EJJA 1ALIA 1EW9A 3BDFA 5INHA 3BDHA 3SZYA 4ZGAA 1SHQA 1URAA 2QZUA 2ANHA 3WAVA 3DYCA 1AJBA 4LR8A 3WAYA 4CXKA 3UN3A 3A52A 4ZG9A 4MHXA 3DPCA 5HRTA 2IUCA 3T02A 3T00A 4KJDA 4CYSA 1SHNA 4CYRA 3TWZA 3UN5A 1ALKA 4KJGA 4UOPA 4LR9A 3BDGA 5GRRA 1EQJA 1KH5A 2RH6A 5K4PA 2W8SA 4UPKA 4YR1A 2D1GA 4LR7A 1AUKA 3UN2A 1P49A 3ED4A 4LQYA 1AJCA 1N2KA 3M8ZA 3KD8A 1EW8A 4NWJA 1ZEFA 4KM4A 4UORA 2W5VA 5DLWA 2W5SA 3SZZA 4UPLA 2W5WA 1HDHA 5EGHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W8D A;  1KHL A;  4CXS A;  3MK0 A;  2G9Y A;  4GTX A;  3NKN A;  5GOV A;  4GTZ A;  3M7V A;  4MY4 A;  1EW2 A;  5LRM A;  1EI6 A;  1URB A;  3M8W A;  4ZG7 A;  1N2L A;  1ED8 A;  1KHJ A;  1ELY A;  3LXQ A;  3M8Y A;  4LRC A;  2ZKT A;  4LRF A;  1ANI A;  4LRE A;  2XRG A;  2VQR A;  4KAV A;  3OT9 A;  2W5Q A;  3WAW A;  4TN0 A;  4LR2 A;  5EGE A;  5DLV A;  1ELX A;  3E2D A;  3IGZ B;  4GTW A;  1FSU A;  5AJ9 A;  3TX0 A;  2IFY A;  4B56 A;  2X98 A;  1ED9 A;  4LRB A;  3IGY B;  5L0K A;  2W5T A;  1O98 A;  3UNY A;  4GTY A;  4UPI A;  1KH7 A;  5KXA A;  1AJD A;  4N7T A;  2GSU A;  4NWX A;  1ANJ A;  1HQA A;  3NKR A;  4CXU A;  1Y7A A;  3BDG B;  1ALH A;  1ZEB A;  5L0B A;  2XR9 A;  1K7H A;  1E2S P;  1ZED A;  3NKO A;  2GSO A;  4UOO A;  1AJA A;  3Q3Q A;  3T01 A;  4FDI A;  2GSN A;  3NKQ A;  3CMR A;  3MK2 A;  1B8J A;  3NVL A;  5DLT A;  3UO0 A;  3B5Q A;  1E33 P;  5IJQ A;  1KHN A;  4LRD A;  2W5X A;  1HJK A;  4QAX A;  5TJ3 A;  3NKP A;  5C66 A;  3WAX A;  5L0E A;  3NKM A;  2GA3 A;  4FDJ A;  2IUC B;  4ZG6 A;  5LRN A;  3TG0 A;  3MK1 A;  3IDD A;  5IJS A;  5LIA A;  1ALJ A;  1O99 A;  2GLQ A;  1KH9 A;  4MIV A;  3WBH A;  1KH4 A;  1KHK A;  5LQQ A;  1Y6V A;  1ELZ A;  1E3C P;  4KAY A;  2W5R A;  4UPH A;  4LRA A;  1E1Z P;  1EJJ A;  1ALI A;  1EW9 A;  3BDF A;  5INH A;  3BDH A;  3SZY A;  4ZGA A;  1SHQ A;  1URA A;  2QZU A;  2ANH A;  3WAV A;  3DYC A;  1AJB A;  4LR8 A;  3WAY A;  4CXK A;  3UN3 A;  3A52 A;  4ZG9 A;  4MHX A;  3DPC A;  5HRT A;  2IUC A;  3T02 A;  3T00 A;  4KJD A;  4CYS A;  1SHN A;  4CYR A;  3TWZ A;  3UN5 A;  1ALK A;  4KJG A;  4UOP A;  4LR9 A;  3BDG A;  5GRR A;  1EQJ A;  1KH5 A;  2RH6 A;  5K4P A;  2W8S A;  4UPK A;  4YR1 A;  2D1G A;  4LR7 A;  1AUK A;  3UN2 A;  1P49 A;  3ED4 A;  4LQY A;  1AJC A;  1N2K A;  3M8Z A;  3KD8 A;  1EW8 A;  4NWJ A;  1ZEF A;  4KM4 A;  4UOR A;  2W5V A;  5DLW A;  2W5S A;  3SZZ A;  4UPL A;  2W5W A;  1HDH A;  5EGH A; 
#chains in the Genus database with same CATH topology
 2W8D A;  1KHL A;  4CXS A;  3MK0 A;  2G9Y A;  4GTX A;  3NKN A;  5GOV A;  4GTZ A;  3M7V A;  4MY4 A;  1EW2 A;  5LRM A;  1EI6 A;  1URB A;  3M8W A;  4ZG7 A;  1N2L A;  1ED8 A;  1KHJ A;  1ELY A;  3LXQ A;  3M8Y A;  4LRC A;  2ZKT A;  4LRF A;  1ANI A;  4LRE A;  2XRG A;  2VQR A;  4KAV A;  3OT9 A;  2W5Q A;  3WAW A;  4TN0 A;  4LR2 A;  5EGE A;  5DLV A;  1ELX A;  3E2D A;  3IGZ B;  4GTW A;  1FSU A;  5AJ9 A;  3TX0 A;  2IFY A;  4B56 A;  2X98 A;  1ED9 A;  4LRB A;  3IGY B;  5L0K A;  2W5T A;  1O98 A;  3UNY A;  4GTY A;  4UPI A;  1KH7 A;  5KXA A;  1AJD A;  4N7T A;  2GSU A;  4NWX A;  1ANJ A;  1HQA A;  3NKR A;  4CXU A;  1Y7A A;  3BDG B;  1ALH A;  1ZEB A;  5L0B A;  2XR9 A;  1K7H A;  1E2S P;  1ZED A;  3NKO A;  2GSO A;  4UOO A;  1AJA A;  3Q3Q A;  3T01 A;  4FDI A;  2GSN A;  3NKQ A;  3CMR A;  3MK2 A;  1B8J A;  3NVL A;  5DLT A;  3UO0 A;  3B5Q A;  1E33 P;  5IJQ A;  1KHN A;  4LRD A;  2W5X A;  1HJK A;  4QAX A;  5TJ3 A;  3NKP A;  5C66 A;  3WAX A;  5L0E A;  3NKM A;  2GA3 A;  4FDJ A;  2IUC B;  4ZG6 A;  5LRN A;  3TG0 A;  3MK1 A;  3IDD A;  5IJS A;  5LIA A;  1ALJ A;  1O99 A;  2GLQ A;  1KH9 A;  4MIV A;  3WBH A;  1KH4 A;  1KHK A;  5LQQ A;  1Y6V A;  1ELZ A;  1E3C P;  4KAY A;  2W5R A;  4UPH A;  4LRA A;  1E1Z P;  1EJJ A;  1ALI A;  1EW9 A;  3BDF A;  5INH A;  3BDH A;  3SZY A;  4ZGA A;  1SHQ A;  1URA A;  2QZU A;  2ANH A;  3WAV A;  3DYC A;  1AJB A;  4LR8 A;  3WAY A;  4CXK A;  3UN3 A;  3A52 A;  4ZG9 A;  4MHX A;  3DPC A;  5HRT A;  2IUC A;  3T02 A;  3T00 A;  4KJD A;  4CYS A;  1SHN A;  4CYR A;  3TWZ A;  3UN5 A;  1ALK A;  4KJG A;  4UOP A;  4LR9 A;  3BDG A;  5GRR A;  1EQJ A;  1KH5 A;  2RH6 A;  5K4P A;  2W8S A;  4UPK A;  4YR1 A;  2D1G A;  4LR7 A;  1AUK A;  3UN2 A;  1P49 A;  3ED4 A;  4LQY A;  1AJC A;  1N2K A;  3M8Z A;  3KD8 A;  1EW8 A;  4NWJ A;  1ZEF A;  4KM4 A;  4UOR A;  2W5V A;  5DLW A;  2W5S A;  3SZZ A;  4UPL A;  2W5W A;  1HDH A;  5EGH A; 
#chains in the Genus database with same CATH homology
 2W8D A;  1KHL A;  4CXS A;  3MK0 A;  2G9Y A;  4GTX A;  3NKN A;  5GOV A;  4GTZ A;  3M7V A;  4MY4 A;  1EW2 A;  5LRM A;  1EI6 A;  1URB A;  3M8W A;  4ZG7 A;  1N2L A;  1ED8 A;  1KHJ A;  1ELY A;  3LXQ A;  3M8Y A;  4LRC A;  2ZKT A;  4LRF A;  1ANI A;  4LRE A;  2XRG A;  2VQR A;  4KAV A;  3OT9 A;  2W5Q A;  3WAW A;  4TN0 A;  4LR2 A;  5EGE A;  5DLV A;  1ELX A;  3E2D A;  3IGZ B;  4GTW A;  1FSU A;  5AJ9 A;  3TX0 A;  2IFY A;  4B56 A;  2X98 A;  1ED9 A;  4LRB A;  3IGY B;  5L0K A;  2W5T A;  1O98 A;  3UNY A;  4GTY A;  4UPI A;  1KH7 A;  5KXA A;  1AJD A;  4N7T A;  2GSU A;  4NWX A;  1ANJ A;  1HQA A;  3NKR A;  4CXU A;  1Y7A A;  3BDG B;  1ALH A;  1ZEB A;  5L0B A;  2XR9 A;  1K7H A;  1E2S P;  1ZED A;  3NKO A;  2GSO A;  4UOO A;  1AJA A;  3Q3Q A;  3T01 A;  4FDI A;  2GSN A;  3NKQ A;  3CMR A;  3MK2 A;  1B8J A;  3NVL A;  5DLT A;  3UO0 A;  3B5Q A;  1E33 P;  5IJQ A;  1KHN A;  4LRD A;  2W5X A;  1HJK A;  4QAX A;  5TJ3 A;  3NKP A;  5C66 A;  3WAX A;  5L0E A;  3NKM A;  2GA3 A;  4FDJ A;  2IUC B;  4ZG6 A;  5LRN A;  3TG0 A;  3MK1 A;  3IDD A;  5IJS A;  5LIA A;  1ALJ A;  1O99 A;  2GLQ A;  1KH9 A;  4MIV A;  3WBH A;  1KH4 A;  1KHK A;  5LQQ A;  1Y6V A;  1ELZ A;  1E3C P;  4KAY A;  2W5R A;  4UPH A;  4LRA A;  1E1Z P;  1EJJ A;  1ALI A;  1EW9 A;  3BDF A;  5INH A;  3BDH A;  3SZY A;  4ZGA A;  1SHQ A;  1URA A;  2QZU A;  2ANH A;  3WAV A;  3DYC A;  1AJB A;  4LR8 A;  3WAY A;  4CXK A;  3UN3 A;  3A52 A;  4ZG9 A;  4MHX A;  3DPC A;  5HRT A;  2IUC A;  3T02 A;  3T00 A;  4KJD A;  4CYS A;  1SHN A;  4CYR A;  3TWZ A;  3UN5 A;  1ALK A;  4KJG A;  4UOP A;  4LR9 A;  3BDG A;  5GRR A;  1EQJ A;  1KH5 A;  2RH6 A;  5K4P A;  2W8S A;  4UPK A;  4YR1 A;  2D1G A;  4LR7 A;  1AUK A;  3UN2 A;  1P49 A;  3ED4 A;  4LQY A;  1AJC A;  1N2K A;  3M8Z A;  3KD8 A;  1EW8 A;  4NWJ A;  1ZEF A;  4KM4 A;  4UOR A;  2W5V A;  5DLW A;  2W5S A;  3SZZ A;  4UPL A;  2W5W A;  1HDH A;  5EGH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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