1ALJA

Alkaline phosphatase mutant (h412n)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aljA00
3MK1A 1EW9A 4NWJA 3BDHA 1O98A 5EGEA 5GOVA 5L0BA 1HDHA 5LIAA 2W8DA 1EI6A 1EQJA 3SZZA 1SHNA 2W5RA 3M8YA 1EW2A 2W5WA 4UPKA 2G9YA 1K7HA 3WAXA 5L0KA 3T01A 2GLQA 5LRMA 4CXKA 3IDDA 1KHLA 3BDGB 1FSUA 3M8WA 1ANJA 1N2LA 4LQYA 1E3CP 4ZG9A 4LR8A 3SZYA 1ALKA 5K4PA 5KXAA 3MK0A 1ALJA 3E2DA 1ELZA 3T00A 3CMRA 1KH9A 4CXSA 2W8SA 3TX0A 2IUCA 1ZEBA 1URBA 3KD8A 3NKNA 2ANHA 1AJCA 4YR1A 1AJBA 2W5VA 4LREA 1ELYA 2IFYA 5LQQA 2W5XA 1O99A 3OT9A 5TJ3A 1AUKA 2W5SA 3MK2A 1ANIA 4CYRA 4FDJA 3DPCA 4N7TA 1P49A 3T02A 5HRTA 3NKOA 4CYSA 2GSNA 3M7VA 4MIVA 1KH4A 4LR7A 3Q3QA 5EGHA 3NKQA 5IJSA 2GSUA 4LRCA 5DLVA 1N2KA 1EJJA 4ZG7A 2QZUA 2VQRA 1E33P 4KAVA 3WAWA 4TN0A 4NWXA 2IUCB 3UO0A 4B56A 4LR2A 2GA3A 1URAA 1E2SP 1SHQA 1ZEFA 4UPLA 1KH7A 1ED8A 1HJKA 4LRDA 2W5QA 4UOOA 3NKPA 4GTZA 5DLWA 3A52A 2W5TA 4LRBA 3NKRA 5DLTA 4QAXA 1B8JA 3UN3A 4KJDA 4KAYA 3UNYA 4GTXA 3TWZA 5INHA 3B5QA 1KHKA 3WAYA 1EW8A 4UPHA 3BDFA 1KH5A 1HQAA 4LRAA 2D1GA 2XRGA 1KHNA 1ALIA 4LR9A 2GSOA 4LRFA 3TG0A 3WBHA 1Y6VA 1KHJA 4ZG6A 4MHXA 1ZEDA 3UN2A 5LRNA 4FDIA 3IGZB 4UPIA 5AJ9A 4UOPA 2X98A 3DYCA 5GRRA 4KM4A 3NKMA 4GTYA 4KJGA 1ELXA 5C66A 3ED4A 3BDGA 2XR9A 3UN5A 1Y7AA 4MY4A 1AJAA 4CXUA 1ED9A 1AJDA 2RH6A 3M8ZA 1ALHA 3LXQA 4UORA 2ZKTA 3WAVA 4GTWA 3NVLA 5IJQA 4ZGAA 5L0EA 3IGYB 1E1ZP
chains in the Genus database with same CATH superfamily
3MK1A 1EW9A 4NWJA 3BDHA 1O98A 5EGEA 5GOVA 5L0BA 1HDHA 5LIAA 2W8DA 1EI6A 1EQJA 3SZZA 1SHNA 2W5RA 3M8YA 1EW2A 2W5WA 4UPKA 2G9YA 1K7HA 3WAXA 5L0KA 3T01A 2GLQA 5LRMA 4CXKA 3IDDA 1KHLA 3BDGB 1FSUA 3M8WA 1ANJA 1N2LA 4LQYA 1E3CP 4ZG9A 4LR8A 3SZYA 1ALKA 5K4PA 5KXAA 3MK0A 1ALJA 3E2DA 1ELZA 3T00A 3CMRA 1KH9A 4CXSA 2W8SA 3TX0A 2IUCA 1ZEBA 1URBA 3KD8A 3NKNA 2ANHA 1AJCA 4YR1A 1AJBA 2W5VA 4LREA 1ELYA 2IFYA 5LQQA 2W5XA 1O99A 3OT9A 5TJ3A 1AUKA 2W5SA 3MK2A 1ANIA 4CYRA 4FDJA 3DPCA 4N7TA 1P49A 3T02A 5HRTA 3NKOA 4CYSA 2GSNA 3M7VA 4MIVA 1KH4A 4LR7A 3Q3QA 5EGHA 3NKQA 5IJSA 2GSUA 4LRCA 5DLVA 1N2KA 1EJJA 4ZG7A 2QZUA 2VQRA 1E33P 4KAVA 3WAWA 4TN0A 4NWXA 2IUCB 3UO0A 4B56A 4LR2A 2GA3A 1URAA 1E2SP 1SHQA 1ZEFA 4UPLA 1KH7A 1ED8A 1HJKA 4LRDA 2W5QA 4UOOA 3NKPA 4GTZA 5DLWA 3A52A 2W5TA 4LRBA 3NKRA 5DLTA 4QAXA 1B8JA 3UN3A 4KJDA 4KAYA 3UNYA 4GTXA 3TWZA 5INHA 3B5QA 1KHKA 3WAYA 1EW8A 4UPHA 3BDFA 1KH5A 1HQAA 4LRAA 2D1GA 2XRGA 1KHNA 1ALIA 4LR9A 2GSOA 4LRFA 3TG0A 3WBHA 1Y6VA 1KHJA 4ZG6A 4MHXA 1ZEDA 3UN2A 5LRNA 4FDIA 3IGZB 4UPIA 5AJ9A 4UOPA 2X98A 3DYCA 5GRRA 4KM4A 3NKMA 4GTYA 4KJGA 1ELXA 5C66A 3ED4A 3BDGA 2XR9A 3UN5A 1Y7AA 4MY4A 1AJAA 4CXUA 1ED9A 1AJDA 2RH6A 3M8ZA 1ALHA 3LXQA 4UORA 2ZKTA 3WAVA 4GTWA 3NVLA 5IJQA 4ZGAA 5L0EA 3IGYB 1E1ZP
chains in the Genus database with same CATH topology
3MK1A 1EW9A 4NWJA 3BDHA 1O98A 5EGEA 5GOVA 5L0BA 1HDHA 5LIAA 2W8DA 1EI6A 1EQJA 3SZZA 1SHNA 2W5RA 3M8YA 1EW2A 2W5WA 4UPKA 2G9YA 1K7HA 3WAXA 5L0KA 3T01A 2GLQA 5LRMA 4CXKA 3IDDA 1KHLA 3BDGB 1FSUA 3M8WA 1ANJA 1N2LA 4LQYA 1E3CP 4ZG9A 4LR8A 3SZYA 1ALKA 5K4PA 5KXAA 3MK0A 1ALJA 3E2DA 1ELZA 3T00A 3CMRA 1KH9A 4CXSA 2W8SA 3TX0A 2IUCA 1ZEBA 1URBA 3KD8A 3NKNA 2ANHA 1AJCA 4YR1A 1AJBA 2W5VA 4LREA 1ELYA 2IFYA 5LQQA 2W5XA 1O99A 3OT9A 5TJ3A 1AUKA 2W5SA 3MK2A 1ANIA 4CYRA 4FDJA 3DPCA 4N7TA 1P49A 3T02A 5HRTA 3NKOA 4CYSA 2GSNA 3M7VA 4MIVA 1KH4A 4LR7A 3Q3QA 5EGHA 3NKQA 5IJSA 2GSUA 4LRCA 5DLVA 1N2KA 1EJJA 4ZG7A 2QZUA 2VQRA 1E33P 4KAVA 3WAWA 4TN0A 4NWXA 2IUCB 3UO0A 4B56A 4LR2A 2GA3A 1URAA 1E2SP 1SHQA 1ZEFA 4UPLA 1KH7A 1ED8A 1HJKA 4LRDA 2W5QA 4UOOA 3NKPA 4GTZA 5DLWA 3A52A 2W5TA 4LRBA 3NKRA 5DLTA 4QAXA 1B8JA 3UN3A 4KJDA 4KAYA 3UNYA 4GTXA 3TWZA 5INHA 3B5QA 1KHKA 3WAYA 1EW8A 4UPHA 3BDFA 1KH5A 1HQAA 4LRAA 2D1GA 2XRGA 1KHNA 1ALIA 4LR9A 2GSOA 4LRFA 3TG0A 3WBHA 1Y6VA 1KHJA 4ZG6A 4MHXA 1ZEDA 3UN2A 5LRNA 4FDIA 3IGZB 4UPIA 5AJ9A 4UOPA 2X98A 3DYCA 5GRRA 4KM4A 3NKMA 4GTYA 4KJGA 1ELXA 5C66A 3ED4A 3BDGA 2XR9A 3UN5A 1Y7AA 4MY4A 1AJAA 4CXUA 1ED9A 1AJDA 2RH6A 3M8ZA 1ALHA 3LXQA 4UORA 2ZKTA 3WAVA 4GTWA 3NVLA 5IJQA 4ZGAA 5L0EA 3IGYB 1E1ZP
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK1 A;  1EW9 A;  4NWJ A;  3BDH A;  1O98 A;  5EGE A;  5GOV A;  5L0B A;  1HDH A;  5LIA A;  2W8D A;  1EI6 A;  1EQJ A;  3SZZ A;  1SHN A;  2W5R A;  3M8Y A;  1EW2 A;  2W5W A;  4UPK A;  2G9Y A;  1K7H A;  3WAX A;  5L0K A;  3T01 A;  2GLQ A;  5LRM A;  4CXK A;  3IDD A;  1KHL A;  3BDG B;  1FSU A;  3M8W A;  1ANJ A;  1N2L A;  4LQY A;  1E3C P;  4ZG9 A;  4LR8 A;  3SZY A;  1ALK A;  5K4P A;  5KXA A;  3MK0 A;  1ALJ A;  3E2D A;  1ELZ A;  3T00 A;  3CMR A;  1KH9 A;  4CXS A;  2W8S A;  3TX0 A;  2IUC A;  1ZEB A;  1URB A;  3KD8 A;  3NKN A;  2ANH A;  1AJC A;  4YR1 A;  1AJB A;  2W5V A;  4LRE A;  1ELY A;  2IFY A;  5LQQ A;  2W5X A;  1O99 A;  3OT9 A;  5TJ3 A;  1AUK A;  2W5S A;  3MK2 A;  1ANI A;  4CYR A;  4FDJ A;  3DPC A;  4N7T A;  1P49 A;  3T02 A;  5HRT A;  3NKO A;  4CYS A;  2GSN A;  3M7V A;  4MIV A;  1KH4 A;  4LR7 A;  3Q3Q A;  5EGH A;  3NKQ A;  5IJS A;  2GSU A;  4LRC A;  5DLV A;  1N2K A;  1EJJ A;  4ZG7 A;  2QZU A;  2VQR A;  1E33 P;  4KAV A;  3WAW A;  4TN0 A;  4NWX A;  2IUC B;  3UO0 A;  4B56 A;  4LR2 A;  2GA3 A;  1URA A;  1E2S P;  1SHQ A;  1ZEF A;  4UPL A;  1KH7 A;  1ED8 A;  1HJK A;  4LRD A;  2W5Q A;  4UOO A;  3NKP A;  4GTZ A;  5DLW A;  3A52 A;  2W5T A;  4LRB A;  3NKR A;  5DLT A;  4QAX A;  1B8J A;  3UN3 A;  4KJD A;  4KAY A;  3UNY A;  4GTX A;  3TWZ A;  5INH A;  3B5Q A;  1KHK A;  3WAY A;  1EW8 A;  4UPH A;  3BDF A;  1KH5 A;  1HQA A;  4LRA A;  2D1G A;  2XRG A;  1KHN A;  1ALI A;  4LR9 A;  2GSO A;  4LRF A;  3TG0 A;  3WBH A;  1Y6V A;  1KHJ A;  4ZG6 A;  4MHX A;  1ZED A;  3UN2 A;  5LRN A;  4FDI A;  3IGZ B;  4UPI A;  5AJ9 A;  4UOP A;  2X98 A;  3DYC A;  5GRR A;  4KM4 A;  3NKM A;  4GTY A;  4KJG A;  1ELX A;  5C66 A;  3ED4 A;  3BDG A;  2XR9 A;  3UN5 A;  1Y7A A;  4MY4 A;  1AJA A;  4CXU A;  1ED9 A;  1AJD A;  2RH6 A;  3M8Z A;  1ALH A;  3LXQ A;  4UOR A;  2ZKT A;  3WAV A;  4GTW A;  3NVL A;  5IJQ A;  4ZGA A;  5L0E A;  3IGY B;  1E1Z P; 
#chains in the Genus database with same CATH topology
 3MK1 A;  1EW9 A;  4NWJ A;  3BDH A;  1O98 A;  5EGE A;  5GOV A;  5L0B A;  1HDH A;  5LIA A;  2W8D A;  1EI6 A;  1EQJ A;  3SZZ A;  1SHN A;  2W5R A;  3M8Y A;  1EW2 A;  2W5W A;  4UPK A;  2G9Y A;  1K7H A;  3WAX A;  5L0K A;  3T01 A;  2GLQ A;  5LRM A;  4CXK A;  3IDD A;  1KHL A;  3BDG B;  1FSU A;  3M8W A;  1ANJ A;  1N2L A;  4LQY A;  1E3C P;  4ZG9 A;  4LR8 A;  3SZY A;  1ALK A;  5K4P A;  5KXA A;  3MK0 A;  1ALJ A;  3E2D A;  1ELZ A;  3T00 A;  3CMR A;  1KH9 A;  4CXS A;  2W8S A;  3TX0 A;  2IUC A;  1ZEB A;  1URB A;  3KD8 A;  3NKN A;  2ANH A;  1AJC A;  4YR1 A;  1AJB A;  2W5V A;  4LRE A;  1ELY A;  2IFY A;  5LQQ A;  2W5X A;  1O99 A;  3OT9 A;  5TJ3 A;  1AUK A;  2W5S A;  3MK2 A;  1ANI A;  4CYR A;  4FDJ A;  3DPC A;  4N7T A;  1P49 A;  3T02 A;  5HRT A;  3NKO A;  4CYS A;  2GSN A;  3M7V A;  4MIV A;  1KH4 A;  4LR7 A;  3Q3Q A;  5EGH A;  3NKQ A;  5IJS A;  2GSU A;  4LRC A;  5DLV A;  1N2K A;  1EJJ A;  4ZG7 A;  2QZU A;  2VQR A;  1E33 P;  4KAV A;  3WAW A;  4TN0 A;  4NWX A;  2IUC B;  3UO0 A;  4B56 A;  4LR2 A;  2GA3 A;  1URA A;  1E2S P;  1SHQ A;  1ZEF A;  4UPL A;  1KH7 A;  1ED8 A;  1HJK A;  4LRD A;  2W5Q A;  4UOO A;  3NKP A;  4GTZ A;  5DLW A;  3A52 A;  2W5T A;  4LRB A;  3NKR A;  5DLT A;  4QAX A;  1B8J A;  3UN3 A;  4KJD A;  4KAY A;  3UNY A;  4GTX A;  3TWZ A;  5INH A;  3B5Q A;  1KHK A;  3WAY A;  1EW8 A;  4UPH A;  3BDF A;  1KH5 A;  1HQA A;  4LRA A;  2D1G A;  2XRG A;  1KHN A;  1ALI A;  4LR9 A;  2GSO A;  4LRF A;  3TG0 A;  3WBH A;  1Y6V A;  1KHJ A;  4ZG6 A;  4MHX A;  1ZED A;  3UN2 A;  5LRN A;  4FDI A;  3IGZ B;  4UPI A;  5AJ9 A;  4UOP A;  2X98 A;  3DYC A;  5GRR A;  4KM4 A;  3NKM A;  4GTY A;  4KJG A;  1ELX A;  5C66 A;  3ED4 A;  3BDG A;  2XR9 A;  3UN5 A;  1Y7A A;  4MY4 A;  1AJA A;  4CXU A;  1ED9 A;  1AJD A;  2RH6 A;  3M8Z A;  1ALH A;  3LXQ A;  4UOR A;  2ZKT A;  3WAV A;  4GTW A;  3NVL A;  5IJQ A;  4ZGA A;  5L0E A;  3IGY B;  1E1Z P; 
#chains in the Genus database with same CATH homology
 3MK1 A;  1EW9 A;  4NWJ A;  3BDH A;  1O98 A;  5EGE A;  5GOV A;  5L0B A;  1HDH A;  5LIA A;  2W8D A;  1EI6 A;  1EQJ A;  3SZZ A;  1SHN A;  2W5R A;  3M8Y A;  1EW2 A;  2W5W A;  4UPK A;  2G9Y A;  1K7H A;  3WAX A;  5L0K A;  3T01 A;  2GLQ A;  5LRM A;  4CXK A;  3IDD A;  1KHL A;  3BDG B;  1FSU A;  3M8W A;  1ANJ A;  1N2L A;  4LQY A;  1E3C P;  4ZG9 A;  4LR8 A;  3SZY A;  1ALK A;  5K4P A;  5KXA A;  3MK0 A;  1ALJ A;  3E2D A;  1ELZ A;  3T00 A;  3CMR A;  1KH9 A;  4CXS A;  2W8S A;  3TX0 A;  2IUC A;  1ZEB A;  1URB A;  3KD8 A;  3NKN A;  2ANH A;  1AJC A;  4YR1 A;  1AJB A;  2W5V A;  4LRE A;  1ELY A;  2IFY A;  5LQQ A;  2W5X A;  1O99 A;  3OT9 A;  5TJ3 A;  1AUK A;  2W5S A;  3MK2 A;  1ANI A;  4CYR A;  4FDJ A;  3DPC A;  4N7T A;  1P49 A;  3T02 A;  5HRT A;  3NKO A;  4CYS A;  2GSN A;  3M7V A;  4MIV A;  1KH4 A;  4LR7 A;  3Q3Q A;  5EGH A;  3NKQ A;  5IJS A;  2GSU A;  4LRC A;  5DLV A;  1N2K A;  1EJJ A;  4ZG7 A;  2QZU A;  2VQR A;  1E33 P;  4KAV A;  3WAW A;  4TN0 A;  4NWX A;  2IUC B;  3UO0 A;  4B56 A;  4LR2 A;  2GA3 A;  1URA A;  1E2S P;  1SHQ A;  1ZEF A;  4UPL A;  1KH7 A;  1ED8 A;  1HJK A;  4LRD A;  2W5Q A;  4UOO A;  3NKP A;  4GTZ A;  5DLW A;  3A52 A;  2W5T A;  4LRB A;  3NKR A;  5DLT A;  4QAX A;  1B8J A;  3UN3 A;  4KJD A;  4KAY A;  3UNY A;  4GTX A;  3TWZ A;  5INH A;  3B5Q A;  1KHK A;  3WAY A;  1EW8 A;  4UPH A;  3BDF A;  1KH5 A;  1HQA A;  4LRA A;  2D1G A;  2XRG A;  1KHN A;  1ALI A;  4LR9 A;  2GSO A;  4LRF A;  3TG0 A;  3WBH A;  1Y6V A;  1KHJ A;  4ZG6 A;  4MHX A;  1ZED A;  3UN2 A;  5LRN A;  4FDI A;  3IGZ B;  4UPI A;  5AJ9 A;  4UOP A;  2X98 A;  3DYC A;  5GRR A;  4KM4 A;  3NKM A;  4GTY A;  4KJG A;  1ELX A;  5C66 A;  3ED4 A;  3BDG A;  2XR9 A;  3UN5 A;  1Y7A A;  4MY4 A;  1AJA A;  4CXU A;  1ED9 A;  1AJD A;  2RH6 A;  3M8Z A;  1ALH A;  3LXQ A;  4UOR A;  2ZKT A;  3WAV A;  4GTW A;  3NVL A;  5IJQ A;  4ZGA A;  5L0E A;  3IGY B;  1E1Z P; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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