1ALJA

Alkaline phosphatase mutant (h412n)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
molecule keywords ALKALINE PHOSPHATASE
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aljA00
1ED9A 4CXSA 3LXQA 1EI6A 5LRNA 1KH9A 5GRRA 3M7VA 1ANJA 1HDHA 2W5XA 4LRAA 5L0BA 4ZG6A 2GSUA 5GOVA 4N7TA 1K7HA 2ANHA 5LIAA 1EW2A 4LR8A 3E2DA 2GSNA 5LQQA 1KHNA 1AJDA 2IFYA 2W5VA 4KAVA 4CYRA 4ZGAA 4YR1A 3BDFA 4UORA 2W8SA 1ED8A 1P49A 3WAXA 3IGZB 3DYCA 3SZYA 3DPCA 1ELXA 4MHXA 2VQRA 3B5QA 1KHKA 4KJGA 1KH7A 1HJKA 1ZEDA 4QAXA 1URAA 4KAYA 5K4PA 3ED4A 1SHNA 2D1GA 2W5TA 1ELYA 4LR7A 5TJ3A 3NKRA 1Y7AA 4ZG7A 3M8WA 3WAVA 1N2LA 1ELZA 4LRDA 4CXKA 4GTWA 1EJJA 3NKNA 1O99A 1ALKA 3M8YA 1E33P 1ALIA 4LRBA 4LR2A 3WAWA 2GA3A 3TG0A 4GTZA 1AUKA 5IJQA 1KH4A 4FDIA 4UOPA 4CXUA 5L0EA 1AJAA 2IUCB 2IUCA 5L0KA 1KHLA 3TX0A 5C66A 3IGYB 2GLQA 3WAYA 5DLWA 1ZEBA 4UPIA 2G9YA 4LREA 1E1ZP 1B8JA 2ZKTA 1ALJA 4LQYA 4TN0A 1E3CP 3M8ZA 3KD8A 4NWJA 4UOOA 1KHJA 3A52A 3NKOA 1EQJA 3T01A 3UN2A 3UO0A 1ALHA 4UPLA 5DLVA 1AJBA 3T02A 2X98A 3UNYA 2GSOA 3MK2A 1EW9A 4GTYA 5INHA 3OT9A 3UN3A 3BDHA 3BDGA 1Y6VA 3BDGB 5KXAA 5LRMA 4FDJA 4ZG9A 1EW8A 3NVLA 3IDDA 4UPKA 4MY4A 4UPHA 1HQAA 3T00A 3NKPA 1SHQA 5EGHA 3TWZA 4KJDA 2QZUA 1FSUA 1AJCA 4CYSA 5EGEA 1ZEFA 2W5WA 5AJ9A 3Q3QA 3CMRA 3NKMA 5DLTA 4NWXA 1O98A 4LR9A 1E2SP 1URBA 2RH6A 5HRTA 2W5QA 4GTXA 3NKQA 4LRCA 1ANIA 2W5SA 4MIVA 3SZZA 1KH5A 3MK0A 2W5RA 2W8DA 4KM4A 1N2KA 4B56A 2XR9A 4LRFA 3UN5A 3WBHA 2XRGA 5IJSA 3MK1A
chains in the Genus database with same CATH superfamily
1ED9A 4CXSA 3LXQA 1EI6A 5LRNA 1KH9A 5GRRA 3M7VA 1ANJA 1HDHA 2W5XA 4LRAA 5L0BA 4ZG6A 2GSUA 5GOVA 4N7TA 1K7HA 2ANHA 5LIAA 1EW2A 4LR8A 3E2DA 2GSNA 5LQQA 1KHNA 1AJDA 2IFYA 2W5VA 4KAVA 4CYRA 4ZGAA 4YR1A 3BDFA 4UORA 2W8SA 1ED8A 1P49A 3WAXA 3IGZB 3DYCA 3SZYA 3DPCA 1ELXA 4MHXA 2VQRA 3B5QA 1KHKA 4KJGA 1KH7A 1HJKA 1ZEDA 4QAXA 1URAA 4KAYA 5K4PA 3ED4A 1SHNA 2D1GA 2W5TA 1ELYA 4LR7A 5TJ3A 3NKRA 1Y7AA 4ZG7A 3M8WA 3WAVA 1N2LA 1ELZA 4LRDA 4CXKA 4GTWA 1EJJA 3NKNA 1O99A 1ALKA 3M8YA 1E33P 1ALIA 4LRBA 4LR2A 3WAWA 2GA3A 3TG0A 4GTZA 1AUKA 5IJQA 1KH4A 4FDIA 4UOPA 4CXUA 5L0EA 1AJAA 2IUCB 2IUCA 5L0KA 1KHLA 3TX0A 5C66A 3IGYB 2GLQA 3WAYA 5DLWA 1ZEBA 4UPIA 2G9YA 4LREA 1E1ZP 1B8JA 2ZKTA 1ALJA 4LQYA 4TN0A 1E3CP 3M8ZA 3KD8A 4NWJA 4UOOA 1KHJA 3A52A 3NKOA 1EQJA 3T01A 3UN2A 3UO0A 1ALHA 4UPLA 5DLVA 1AJBA 3T02A 2X98A 3UNYA 2GSOA 3MK2A 1EW9A 4GTYA 5INHA 3OT9A 3UN3A 3BDHA 3BDGA 1Y6VA 3BDGB 5KXAA 5LRMA 4FDJA 4ZG9A 1EW8A 3NVLA 3IDDA 4UPKA 4MY4A 4UPHA 1HQAA 3T00A 3NKPA 1SHQA 5EGHA 3TWZA 4KJDA 2QZUA 1FSUA 1AJCA 4CYSA 5EGEA 1ZEFA 2W5WA 5AJ9A 3Q3QA 3CMRA 3NKMA 5DLTA 4NWXA 1O98A 4LR9A 1E2SP 1URBA 2RH6A 5HRTA 2W5QA 4GTXA 3NKQA 4LRCA 1ANIA 2W5SA 4MIVA 3SZZA 1KH5A 3MK0A 2W5RA 2W8DA 4KM4A 1N2KA 4B56A 2XR9A 4LRFA 3UN5A 3WBHA 2XRGA 5IJSA 3MK1A
chains in the Genus database with same CATH topology
1ED9A 4CXSA 3LXQA 1EI6A 5LRNA 1KH9A 5GRRA 3M7VA 1ANJA 1HDHA 2W5XA 4LRAA 5L0BA 4ZG6A 2GSUA 5GOVA 4N7TA 1K7HA 2ANHA 5LIAA 1EW2A 4LR8A 3E2DA 2GSNA 5LQQA 1KHNA 1AJDA 2IFYA 2W5VA 4KAVA 4CYRA 4ZGAA 4YR1A 3BDFA 4UORA 2W8SA 1ED8A 1P49A 3WAXA 3IGZB 3DYCA 3SZYA 3DPCA 1ELXA 4MHXA 2VQRA 3B5QA 1KHKA 4KJGA 1KH7A 1HJKA 1ZEDA 4QAXA 1URAA 4KAYA 5K4PA 3ED4A 1SHNA 2D1GA 2W5TA 1ELYA 4LR7A 5TJ3A 3NKRA 1Y7AA 4ZG7A 3M8WA 3WAVA 1N2LA 1ELZA 4LRDA 4CXKA 4GTWA 1EJJA 3NKNA 1O99A 1ALKA 3M8YA 1E33P 1ALIA 4LRBA 4LR2A 3WAWA 2GA3A 3TG0A 4GTZA 1AUKA 5IJQA 1KH4A 4FDIA 4UOPA 4CXUA 5L0EA 1AJAA 2IUCB 2IUCA 5L0KA 1KHLA 3TX0A 5C66A 3IGYB 2GLQA 3WAYA 5DLWA 1ZEBA 4UPIA 2G9YA 4LREA 1E1ZP 1B8JA 2ZKTA 1ALJA 4LQYA 4TN0A 1E3CP 3M8ZA 3KD8A 4NWJA 4UOOA 1KHJA 3A52A 3NKOA 1EQJA 3T01A 3UN2A 3UO0A 1ALHA 4UPLA 5DLVA 1AJBA 3T02A 2X98A 3UNYA 2GSOA 3MK2A 1EW9A 4GTYA 5INHA 3OT9A 3UN3A 3BDHA 3BDGA 1Y6VA 3BDGB 5KXAA 5LRMA 4FDJA 4ZG9A 1EW8A 3NVLA 3IDDA 4UPKA 4MY4A 4UPHA 1HQAA 3T00A 3NKPA 1SHQA 5EGHA 3TWZA 4KJDA 2QZUA 1FSUA 1AJCA 4CYSA 5EGEA 1ZEFA 2W5WA 5AJ9A 3Q3QA 3CMRA 3NKMA 5DLTA 4NWXA 1O98A 4LR9A 1E2SP 1URBA 2RH6A 5HRTA 2W5QA 4GTXA 3NKQA 4LRCA 1ANIA 2W5SA 4MIVA 3SZZA 1KH5A 3MK0A 2W5RA 2W8DA 4KM4A 1N2KA 4B56A 2XR9A 4LRFA 3UN5A 3WBHA 2XRGA 5IJSA 3MK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED9 A;  4CXS A;  3LXQ A;  1EI6 A;  5LRN A;  1KH9 A;  5GRR A;  3M7V A;  1ANJ A;  1HDH A;  2W5X A;  4LRA A;  5L0B A;  4ZG6 A;  2GSU A;  5GOV A;  4N7T A;  1K7H A;  2ANH A;  5LIA A;  1EW2 A;  4LR8 A;  3E2D A;  2GSN A;  5LQQ A;  1KHN A;  1AJD A;  2IFY A;  2W5V A;  4KAV A;  4CYR A;  4ZGA A;  4YR1 A;  3BDF A;  4UOR A;  2W8S A;  1ED8 A;  1P49 A;  3WAX A;  3IGZ B;  3DYC A;  3SZY A;  3DPC A;  1ELX A;  4MHX A;  2VQR A;  3B5Q A;  1KHK A;  4KJG A;  1KH7 A;  1HJK A;  1ZED A;  4QAX A;  1URA A;  4KAY A;  5K4P A;  3ED4 A;  1SHN A;  2D1G A;  2W5T A;  1ELY A;  4LR7 A;  5TJ3 A;  3NKR A;  1Y7A A;  4ZG7 A;  3M8W A;  3WAV A;  1N2L A;  1ELZ A;  4LRD A;  4CXK A;  4GTW A;  1EJJ A;  3NKN A;  1O99 A;  1ALK A;  3M8Y A;  1E33 P;  1ALI A;  4LRB A;  4LR2 A;  3WAW A;  2GA3 A;  3TG0 A;  4GTZ A;  1AUK A;  5IJQ A;  1KH4 A;  4FDI A;  4UOP A;  4CXU A;  5L0E A;  1AJA A;  2IUC B;  2IUC A;  5L0K A;  1KHL A;  3TX0 A;  5C66 A;  3IGY B;  2GLQ A;  3WAY A;  5DLW A;  1ZEB A;  4UPI A;  2G9Y A;  4LRE A;  1E1Z P;  1B8J A;  2ZKT A;  1ALJ A;  4LQY A;  4TN0 A;  1E3C P;  3M8Z A;  3KD8 A;  4NWJ A;  4UOO A;  1KHJ A;  3A52 A;  3NKO A;  1EQJ A;  3T01 A;  3UN2 A;  3UO0 A;  1ALH A;  4UPL A;  5DLV A;  1AJB A;  3T02 A;  2X98 A;  3UNY A;  2GSO A;  3MK2 A;  1EW9 A;  4GTY A;  5INH A;  3OT9 A;  3UN3 A;  3BDH A;  3BDG A;  1Y6V A;  3BDG B;  5KXA A;  5LRM A;  4FDJ A;  4ZG9 A;  1EW8 A;  3NVL A;  3IDD A;  4UPK A;  4MY4 A;  4UPH A;  1HQA A;  3T00 A;  3NKP A;  1SHQ A;  5EGH A;  3TWZ A;  4KJD A;  2QZU A;  1FSU A;  1AJC A;  4CYS A;  5EGE A;  1ZEF A;  2W5W A;  5AJ9 A;  3Q3Q A;  3CMR A;  3NKM A;  5DLT A;  4NWX A;  1O98 A;  4LR9 A;  1E2S P;  1URB A;  2RH6 A;  5HRT A;  2W5Q A;  4GTX A;  3NKQ A;  4LRC A;  1ANI A;  2W5S A;  4MIV A;  3SZZ A;  1KH5 A;  3MK0 A;  2W5R A;  2W8D A;  4KM4 A;  1N2K A;  4B56 A;  2XR9 A;  4LRF A;  3UN5 A;  3WBH A;  2XRG A;  5IJS A;  3MK1 A; 
#chains in the Genus database with same CATH topology
 1ED9 A;  4CXS A;  3LXQ A;  1EI6 A;  5LRN A;  1KH9 A;  5GRR A;  3M7V A;  1ANJ A;  1HDH A;  2W5X A;  4LRA A;  5L0B A;  4ZG6 A;  2GSU A;  5GOV A;  4N7T A;  1K7H A;  2ANH A;  5LIA A;  1EW2 A;  4LR8 A;  3E2D A;  2GSN A;  5LQQ A;  1KHN A;  1AJD A;  2IFY A;  2W5V A;  4KAV A;  4CYR A;  4ZGA A;  4YR1 A;  3BDF A;  4UOR A;  2W8S A;  1ED8 A;  1P49 A;  3WAX A;  3IGZ B;  3DYC A;  3SZY A;  3DPC A;  1ELX A;  4MHX A;  2VQR A;  3B5Q A;  1KHK A;  4KJG A;  1KH7 A;  1HJK A;  1ZED A;  4QAX A;  1URA A;  4KAY A;  5K4P A;  3ED4 A;  1SHN A;  2D1G A;  2W5T A;  1ELY A;  4LR7 A;  5TJ3 A;  3NKR A;  1Y7A A;  4ZG7 A;  3M8W A;  3WAV A;  1N2L A;  1ELZ A;  4LRD A;  4CXK A;  4GTW A;  1EJJ A;  3NKN A;  1O99 A;  1ALK A;  3M8Y A;  1E33 P;  1ALI A;  4LRB A;  4LR2 A;  3WAW A;  2GA3 A;  3TG0 A;  4GTZ A;  1AUK A;  5IJQ A;  1KH4 A;  4FDI A;  4UOP A;  4CXU A;  5L0E A;  1AJA A;  2IUC B;  2IUC A;  5L0K A;  1KHL A;  3TX0 A;  5C66 A;  3IGY B;  2GLQ A;  3WAY A;  5DLW A;  1ZEB A;  4UPI A;  2G9Y A;  4LRE A;  1E1Z P;  1B8J A;  2ZKT A;  1ALJ A;  4LQY A;  4TN0 A;  1E3C P;  3M8Z A;  3KD8 A;  4NWJ A;  4UOO A;  1KHJ A;  3A52 A;  3NKO A;  1EQJ A;  3T01 A;  3UN2 A;  3UO0 A;  1ALH A;  4UPL A;  5DLV A;  1AJB A;  3T02 A;  2X98 A;  3UNY A;  2GSO A;  3MK2 A;  1EW9 A;  4GTY A;  5INH A;  3OT9 A;  3UN3 A;  3BDH A;  3BDG A;  1Y6V A;  3BDG B;  5KXA A;  5LRM A;  4FDJ A;  4ZG9 A;  1EW8 A;  3NVL A;  3IDD A;  4UPK A;  4MY4 A;  4UPH A;  1HQA A;  3T00 A;  3NKP A;  1SHQ A;  5EGH A;  3TWZ A;  4KJD A;  2QZU A;  1FSU A;  1AJC A;  4CYS A;  5EGE A;  1ZEF A;  2W5W A;  5AJ9 A;  3Q3Q A;  3CMR A;  3NKM A;  5DLT A;  4NWX A;  1O98 A;  4LR9 A;  1E2S P;  1URB A;  2RH6 A;  5HRT A;  2W5Q A;  4GTX A;  3NKQ A;  4LRC A;  1ANI A;  2W5S A;  4MIV A;  3SZZ A;  1KH5 A;  3MK0 A;  2W5R A;  2W8D A;  4KM4 A;  1N2K A;  4B56 A;  2XR9 A;  4LRF A;  3UN5 A;  3WBH A;  2XRG A;  5IJS A;  3MK1 A; 
#chains in the Genus database with same CATH homology
 1ED9 A;  4CXS A;  3LXQ A;  1EI6 A;  5LRN A;  1KH9 A;  5GRR A;  3M7V A;  1ANJ A;  1HDH A;  2W5X A;  4LRA A;  5L0B A;  4ZG6 A;  2GSU A;  5GOV A;  4N7T A;  1K7H A;  2ANH A;  5LIA A;  1EW2 A;  4LR8 A;  3E2D A;  2GSN A;  5LQQ A;  1KHN A;  1AJD A;  2IFY A;  2W5V A;  4KAV A;  4CYR A;  4ZGA A;  4YR1 A;  3BDF A;  4UOR A;  2W8S A;  1ED8 A;  1P49 A;  3WAX A;  3IGZ B;  3DYC A;  3SZY A;  3DPC A;  1ELX A;  4MHX A;  2VQR A;  3B5Q A;  1KHK A;  4KJG A;  1KH7 A;  1HJK A;  1ZED A;  4QAX A;  1URA A;  4KAY A;  5K4P A;  3ED4 A;  1SHN A;  2D1G A;  2W5T A;  1ELY A;  4LR7 A;  5TJ3 A;  3NKR A;  1Y7A A;  4ZG7 A;  3M8W A;  3WAV A;  1N2L A;  1ELZ A;  4LRD A;  4CXK A;  4GTW A;  1EJJ A;  3NKN A;  1O99 A;  1ALK A;  3M8Y A;  1E33 P;  1ALI A;  4LRB A;  4LR2 A;  3WAW A;  2GA3 A;  3TG0 A;  4GTZ A;  1AUK A;  5IJQ A;  1KH4 A;  4FDI A;  4UOP A;  4CXU A;  5L0E A;  1AJA A;  2IUC B;  2IUC A;  5L0K A;  1KHL A;  3TX0 A;  5C66 A;  3IGY B;  2GLQ A;  3WAY A;  5DLW A;  1ZEB A;  4UPI A;  2G9Y A;  4LRE A;  1E1Z P;  1B8J A;  2ZKT A;  1ALJ A;  4LQY A;  4TN0 A;  1E3C P;  3M8Z A;  3KD8 A;  4NWJ A;  4UOO A;  1KHJ A;  3A52 A;  3NKO A;  1EQJ A;  3T01 A;  3UN2 A;  3UO0 A;  1ALH A;  4UPL A;  5DLV A;  1AJB A;  3T02 A;  2X98 A;  3UNY A;  2GSO A;  3MK2 A;  1EW9 A;  4GTY A;  5INH A;  3OT9 A;  3UN3 A;  3BDH A;  3BDG A;  1Y6V A;  3BDG B;  5KXA A;  5LRM A;  4FDJ A;  4ZG9 A;  1EW8 A;  3NVL A;  3IDD A;  4UPK A;  4MY4 A;  4UPH A;  1HQA A;  3T00 A;  3NKP A;  1SHQ A;  5EGH A;  3TWZ A;  4KJD A;  2QZU A;  1FSU A;  1AJC A;  4CYS A;  5EGE A;  1ZEF A;  2W5W A;  5AJ9 A;  3Q3Q A;  3CMR A;  3NKM A;  5DLT A;  4NWX A;  1O98 A;  4LR9 A;  1E2S P;  1URB A;  2RH6 A;  5HRT A;  2W5Q A;  4GTX A;  3NKQ A;  4LRC A;  1ANI A;  2W5S A;  4MIV A;  3SZZ A;  1KH5 A;  3MK0 A;  2W5R A;  2W8D A;  4KM4 A;  1N2K A;  4B56 A;  2XR9 A;  4LRF A;  3UN5 A;  3WBH A;  2XRG A;  5IJS A;  3MK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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