1ALJA

Alkaline phosphatase mutant (h412n)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase (phosphoric monoester)
molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aljA00
1ED8A 1KHLA 1N2KA 3MK1A 3NKQA 3T01A 4LRFA 1ELZA 3E2DA 2IUCB 4FDIA 2W5TA 1ANIA 4KAVA 4GTWA 3MK0A 4UOPA 5DLVA 4CXKA 1E33P 1ALIA 1URAA 1KHKA 2VQRA 5DLWA 3WAYA 1Y7AA 3SZYA 1Y6VA 2W5XA 3KD8A 1ED9A 4MIVA 3OT9A 1EW8A 4ZG6A 5L0BA 4TN0A 3BDHA 4LR7A 1N2LA 1SHNA 5DLTA 4ZG7A 3UNYA 5IJQA 2W8SA 4ZGAA 5KXAA 1E3CP 1AJCA 5TJ3A 3LXQA 3BDGB 5INHA 3ED4A 5LQQA 2GA3A 2IFYA 5GRRA 2GLQA 3NKMA 2ZKTA 1AJDA 1ALKA 3NKRA 4UPLA 3DPCA 1HJKA 1AJBA 1HQAA 2GSNA 4ZG9A 4UPHA 4LRCA 1AJAA 1ELXA 2XR9A 3Q3QA 4LREA 2QZUA 3UO0A 4YR1A 1KHJA 1EI6A 1KH4A 4LR8A 1O98A 2GSOA 1KHNA 1EW2A 1ZEFA 3CMRA 4LRBA 4QAXA 3B5QA 1KH7A 1URBA 4UPKA 3WBHA 5AJ9A 4CYRA 3NVLA 3SZZA 4LR2A 1ALHA 2ANHA 2IUCA 2W5WA 3M7VA 4KAYA 4UPIA 3WAVA 3UN2A 5LIAA 3NKPA 5L0KA 4UORA 4UOOA 2W5QA 1E1ZP 4CXSA 3M8WA 4LR9A 1ZEBA 1P49A 1AUKA 3UN5A 1O99A 2W5VA 4B56A 3UN3A 5LRMA 5IJSA 5EGHA 3T02A 4GTZA 3IGZB 4NWXA 3MK2A 4KJGA 3WAWA 4LRDA 4MHXA 3DYCA 3M8ZA 2GSUA 2W5RA 2G9YA 3NKNA 2D1GA 1EQJA 1HDHA 3BDFA 4NWJA 1SHQA 4KM4A 3NKOA 4KJDA 3TX0A 5EGEA 5LRNA 3TWZA 4LRAA 1FSUA 4CXUA 1ANJA 5K4PA 1EW9A 1ELYA 3M8YA 1E2SP 3T00A 5HRTA 1B8JA 3TG0A 2X98A 4GTYA 1ZEDA 5C66A 3A52A 4MY4A 3IDDA 2W5SA 3IGYB 4FDJA 4N7TA 5L0EA 3BDGA 4LQYA 3WAXA 2XRGA 1ALJA 1KH9A 1EJJA 4CYSA 5GOVA 2W8DA 2RH6A 4GTXA 1K7HA 1KH5A
chains in the Genus database with same CATH superfamily
1ED8A 1KHLA 1N2KA 3MK1A 3NKQA 3T01A 4LRFA 1ELZA 3E2DA 2IUCB 4FDIA 2W5TA 1ANIA 4KAVA 4GTWA 3MK0A 4UOPA 5DLVA 4CXKA 1E33P 1ALIA 1URAA 1KHKA 2VQRA 5DLWA 3WAYA 1Y7AA 3SZYA 1Y6VA 2W5XA 3KD8A 1ED9A 4MIVA 3OT9A 1EW8A 4ZG6A 5L0BA 4TN0A 3BDHA 4LR7A 1N2LA 1SHNA 5DLTA 4ZG7A 3UNYA 5IJQA 2W8SA 4ZGAA 5KXAA 1E3CP 1AJCA 5TJ3A 3LXQA 3BDGB 5INHA 3ED4A 5LQQA 2GA3A 2IFYA 5GRRA 2GLQA 3NKMA 2ZKTA 1AJDA 1ALKA 3NKRA 4UPLA 3DPCA 1HJKA 1AJBA 1HQAA 2GSNA 4ZG9A 4UPHA 4LRCA 1AJAA 1ELXA 2XR9A 3Q3QA 4LREA 2QZUA 3UO0A 4YR1A 1KHJA 1EI6A 1KH4A 4LR8A 1O98A 2GSOA 1KHNA 1EW2A 1ZEFA 3CMRA 4LRBA 4QAXA 3B5QA 1KH7A 1URBA 4UPKA 3WBHA 5AJ9A 4CYRA 3NVLA 3SZZA 4LR2A 1ALHA 2ANHA 2IUCA 2W5WA 3M7VA 4KAYA 4UPIA 3WAVA 3UN2A 5LIAA 3NKPA 5L0KA 4UORA 4UOOA 2W5QA 1E1ZP 4CXSA 3M8WA 4LR9A 1ZEBA 1P49A 1AUKA 3UN5A 1O99A 2W5VA 4B56A 3UN3A 5LRMA 5IJSA 5EGHA 3T02A 4GTZA 3IGZB 4NWXA 3MK2A 4KJGA 3WAWA 4LRDA 4MHXA 3DYCA 3M8ZA 2GSUA 2W5RA 2G9YA 3NKNA 2D1GA 1EQJA 1HDHA 3BDFA 4NWJA 1SHQA 4KM4A 3NKOA 4KJDA 3TX0A 5EGEA 5LRNA 3TWZA 4LRAA 1FSUA 4CXUA 1ANJA 5K4PA 1EW9A 1ELYA 3M8YA 1E2SP 3T00A 5HRTA 1B8JA 3TG0A 2X98A 4GTYA 1ZEDA 5C66A 3A52A 4MY4A 3IDDA 2W5SA 3IGYB 4FDJA 4N7TA 5L0EA 3BDGA 4LQYA 3WAXA 2XRGA 1ALJA 1KH9A 1EJJA 4CYSA 5GOVA 2W8DA 2RH6A 4GTXA 1K7HA 1KH5A
chains in the Genus database with same CATH topology
1ED8A 1KHLA 1N2KA 3MK1A 3NKQA 3T01A 4LRFA 1ELZA 3E2DA 2IUCB 4FDIA 2W5TA 1ANIA 4KAVA 4GTWA 3MK0A 4UOPA 5DLVA 4CXKA 1E33P 1ALIA 1URAA 1KHKA 2VQRA 5DLWA 3WAYA 1Y7AA 3SZYA 1Y6VA 2W5XA 3KD8A 1ED9A 4MIVA 3OT9A 1EW8A 4ZG6A 5L0BA 4TN0A 3BDHA 4LR7A 1N2LA 1SHNA 5DLTA 4ZG7A 3UNYA 5IJQA 2W8SA 4ZGAA 5KXAA 1E3CP 1AJCA 5TJ3A 3LXQA 3BDGB 5INHA 3ED4A 5LQQA 2GA3A 2IFYA 5GRRA 2GLQA 3NKMA 2ZKTA 1AJDA 1ALKA 3NKRA 4UPLA 3DPCA 1HJKA 1AJBA 1HQAA 2GSNA 4ZG9A 4UPHA 4LRCA 1AJAA 1ELXA 2XR9A 3Q3QA 4LREA 2QZUA 3UO0A 4YR1A 1KHJA 1EI6A 1KH4A 4LR8A 1O98A 2GSOA 1KHNA 1EW2A 1ZEFA 3CMRA 4LRBA 4QAXA 3B5QA 1KH7A 1URBA 4UPKA 3WBHA 5AJ9A 4CYRA 3NVLA 3SZZA 4LR2A 1ALHA 2ANHA 2IUCA 2W5WA 3M7VA 4KAYA 4UPIA 3WAVA 3UN2A 5LIAA 3NKPA 5L0KA 4UORA 4UOOA 2W5QA 1E1ZP 4CXSA 3M8WA 4LR9A 1ZEBA 1P49A 1AUKA 3UN5A 1O99A 2W5VA 4B56A 3UN3A 5LRMA 5IJSA 5EGHA 3T02A 4GTZA 3IGZB 4NWXA 3MK2A 4KJGA 3WAWA 4LRDA 4MHXA 3DYCA 3M8ZA 2GSUA 2W5RA 2G9YA 3NKNA 2D1GA 1EQJA 1HDHA 3BDFA 4NWJA 1SHQA 4KM4A 3NKOA 4KJDA 3TX0A 5EGEA 5LRNA 3TWZA 4LRAA 1FSUA 4CXUA 1ANJA 5K4PA 1EW9A 1ELYA 3M8YA 1E2SP 3T00A 5HRTA 1B8JA 3TG0A 2X98A 4GTYA 1ZEDA 5C66A 3A52A 4MY4A 3IDDA 2W5SA 3IGYB 4FDJA 4N7TA 5L0EA 3BDGA 4LQYA 3WAXA 2XRGA 1ALJA 1KH9A 1EJJA 4CYSA 5GOVA 2W8DA 2RH6A 4GTXA 1K7HA 1KH5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED8 A;  1KHL A;  1N2K A;  3MK1 A;  3NKQ A;  3T01 A;  4LRF A;  1ELZ A;  3E2D A;  2IUC B;  4FDI A;  2W5T A;  1ANI A;  4KAV A;  4GTW A;  3MK0 A;  4UOP A;  5DLV A;  4CXK A;  1E33 P;  1ALI A;  1URA A;  1KHK A;  2VQR A;  5DLW A;  3WAY A;  1Y7A A;  3SZY A;  1Y6V A;  2W5X A;  3KD8 A;  1ED9 A;  4MIV A;  3OT9 A;  1EW8 A;  4ZG6 A;  5L0B A;  4TN0 A;  3BDH A;  4LR7 A;  1N2L A;  1SHN A;  5DLT A;  4ZG7 A;  3UNY A;  5IJQ A;  2W8S A;  4ZGA A;  5KXA A;  1E3C P;  1AJC A;  5TJ3 A;  3LXQ A;  3BDG B;  5INH A;  3ED4 A;  5LQQ A;  2GA3 A;  2IFY A;  5GRR A;  2GLQ A;  3NKM A;  2ZKT A;  1AJD A;  1ALK A;  3NKR A;  4UPL A;  3DPC A;  1HJK A;  1AJB A;  1HQA A;  2GSN A;  4ZG9 A;  4UPH A;  4LRC A;  1AJA A;  1ELX A;  2XR9 A;  3Q3Q A;  4LRE A;  2QZU A;  3UO0 A;  4YR1 A;  1KHJ A;  1EI6 A;  1KH4 A;  4LR8 A;  1O98 A;  2GSO A;  1KHN A;  1EW2 A;  1ZEF A;  3CMR A;  4LRB A;  4QAX A;  3B5Q A;  1KH7 A;  1URB A;  4UPK A;  3WBH A;  5AJ9 A;  4CYR A;  3NVL A;  3SZZ A;  4LR2 A;  1ALH A;  2ANH A;  2IUC A;  2W5W A;  3M7V A;  4KAY A;  4UPI A;  3WAV A;  3UN2 A;  5LIA A;  3NKP A;  5L0K A;  4UOR A;  4UOO A;  2W5Q A;  1E1Z P;  4CXS A;  3M8W A;  4LR9 A;  1ZEB A;  1P49 A;  1AUK A;  3UN5 A;  1O99 A;  2W5V A;  4B56 A;  3UN3 A;  5LRM A;  5IJS A;  5EGH A;  3T02 A;  4GTZ A;  3IGZ B;  4NWX A;  3MK2 A;  4KJG A;  3WAW A;  4LRD A;  4MHX A;  3DYC A;  3M8Z A;  2GSU A;  2W5R A;  2G9Y A;  3NKN A;  2D1G A;  1EQJ A;  1HDH A;  3BDF A;  4NWJ A;  1SHQ A;  4KM4 A;  3NKO A;  4KJD A;  3TX0 A;  5EGE A;  5LRN A;  3TWZ A;  4LRA A;  1FSU A;  4CXU A;  1ANJ A;  5K4P A;  1EW9 A;  1ELY A;  3M8Y A;  1E2S P;  3T00 A;  5HRT A;  1B8J A;  3TG0 A;  2X98 A;  4GTY A;  1ZED A;  5C66 A;  3A52 A;  4MY4 A;  3IDD A;  2W5S A;  3IGY B;  4FDJ A;  4N7T A;  5L0E A;  3BDG A;  4LQY A;  3WAX A;  2XRG A;  1ALJ A;  1KH9 A;  1EJJ A;  4CYS A;  5GOV A;  2W8D A;  2RH6 A;  4GTX A;  1K7H A;  1KH5 A; 
#chains in the Genus database with same CATH topology
 1ED8 A;  1KHL A;  1N2K A;  3MK1 A;  3NKQ A;  3T01 A;  4LRF A;  1ELZ A;  3E2D A;  2IUC B;  4FDI A;  2W5T A;  1ANI A;  4KAV A;  4GTW A;  3MK0 A;  4UOP A;  5DLV A;  4CXK A;  1E33 P;  1ALI A;  1URA A;  1KHK A;  2VQR A;  5DLW A;  3WAY A;  1Y7A A;  3SZY A;  1Y6V A;  2W5X A;  3KD8 A;  1ED9 A;  4MIV A;  3OT9 A;  1EW8 A;  4ZG6 A;  5L0B A;  4TN0 A;  3BDH A;  4LR7 A;  1N2L A;  1SHN A;  5DLT A;  4ZG7 A;  3UNY A;  5IJQ A;  2W8S A;  4ZGA A;  5KXA A;  1E3C P;  1AJC A;  5TJ3 A;  3LXQ A;  3BDG B;  5INH A;  3ED4 A;  5LQQ A;  2GA3 A;  2IFY A;  5GRR A;  2GLQ A;  3NKM A;  2ZKT A;  1AJD A;  1ALK A;  3NKR A;  4UPL A;  3DPC A;  1HJK A;  1AJB A;  1HQA A;  2GSN A;  4ZG9 A;  4UPH A;  4LRC A;  1AJA A;  1ELX A;  2XR9 A;  3Q3Q A;  4LRE A;  2QZU A;  3UO0 A;  4YR1 A;  1KHJ A;  1EI6 A;  1KH4 A;  4LR8 A;  1O98 A;  2GSO A;  1KHN A;  1EW2 A;  1ZEF A;  3CMR A;  4LRB A;  4QAX A;  3B5Q A;  1KH7 A;  1URB A;  4UPK A;  3WBH A;  5AJ9 A;  4CYR A;  3NVL A;  3SZZ A;  4LR2 A;  1ALH A;  2ANH A;  2IUC A;  2W5W A;  3M7V A;  4KAY A;  4UPI A;  3WAV A;  3UN2 A;  5LIA A;  3NKP A;  5L0K A;  4UOR A;  4UOO A;  2W5Q A;  1E1Z P;  4CXS A;  3M8W A;  4LR9 A;  1ZEB A;  1P49 A;  1AUK A;  3UN5 A;  1O99 A;  2W5V A;  4B56 A;  3UN3 A;  5LRM A;  5IJS A;  5EGH A;  3T02 A;  4GTZ A;  3IGZ B;  4NWX A;  3MK2 A;  4KJG A;  3WAW A;  4LRD A;  4MHX A;  3DYC A;  3M8Z A;  2GSU A;  2W5R A;  2G9Y A;  3NKN A;  2D1G A;  1EQJ A;  1HDH A;  3BDF A;  4NWJ A;  1SHQ A;  4KM4 A;  3NKO A;  4KJD A;  3TX0 A;  5EGE A;  5LRN A;  3TWZ A;  4LRA A;  1FSU A;  4CXU A;  1ANJ A;  5K4P A;  1EW9 A;  1ELY A;  3M8Y A;  1E2S P;  3T00 A;  5HRT A;  1B8J A;  3TG0 A;  2X98 A;  4GTY A;  1ZED A;  5C66 A;  3A52 A;  4MY4 A;  3IDD A;  2W5S A;  3IGY B;  4FDJ A;  4N7T A;  5L0E A;  3BDG A;  4LQY A;  3WAX A;  2XRG A;  1ALJ A;  1KH9 A;  1EJJ A;  4CYS A;  5GOV A;  2W8D A;  2RH6 A;  4GTX A;  1K7H A;  1KH5 A; 
#chains in the Genus database with same CATH homology
 1ED8 A;  1KHL A;  1N2K A;  3MK1 A;  3NKQ A;  3T01 A;  4LRF A;  1ELZ A;  3E2D A;  2IUC B;  4FDI A;  2W5T A;  1ANI A;  4KAV A;  4GTW A;  3MK0 A;  4UOP A;  5DLV A;  4CXK A;  1E33 P;  1ALI A;  1URA A;  1KHK A;  2VQR A;  5DLW A;  3WAY A;  1Y7A A;  3SZY A;  1Y6V A;  2W5X A;  3KD8 A;  1ED9 A;  4MIV A;  3OT9 A;  1EW8 A;  4ZG6 A;  5L0B A;  4TN0 A;  3BDH A;  4LR7 A;  1N2L A;  1SHN A;  5DLT A;  4ZG7 A;  3UNY A;  5IJQ A;  2W8S A;  4ZGA A;  5KXA A;  1E3C P;  1AJC A;  5TJ3 A;  3LXQ A;  3BDG B;  5INH A;  3ED4 A;  5LQQ A;  2GA3 A;  2IFY A;  5GRR A;  2GLQ A;  3NKM A;  2ZKT A;  1AJD A;  1ALK A;  3NKR A;  4UPL A;  3DPC A;  1HJK A;  1AJB A;  1HQA A;  2GSN A;  4ZG9 A;  4UPH A;  4LRC A;  1AJA A;  1ELX A;  2XR9 A;  3Q3Q A;  4LRE A;  2QZU A;  3UO0 A;  4YR1 A;  1KHJ A;  1EI6 A;  1KH4 A;  4LR8 A;  1O98 A;  2GSO A;  1KHN A;  1EW2 A;  1ZEF A;  3CMR A;  4LRB A;  4QAX A;  3B5Q A;  1KH7 A;  1URB A;  4UPK A;  3WBH A;  5AJ9 A;  4CYR A;  3NVL A;  3SZZ A;  4LR2 A;  1ALH A;  2ANH A;  2IUC A;  2W5W A;  3M7V A;  4KAY A;  4UPI A;  3WAV A;  3UN2 A;  5LIA A;  3NKP A;  5L0K A;  4UOR A;  4UOO A;  2W5Q A;  1E1Z P;  4CXS A;  3M8W A;  4LR9 A;  1ZEB A;  1P49 A;  1AUK A;  3UN5 A;  1O99 A;  2W5V A;  4B56 A;  3UN3 A;  5LRM A;  5IJS A;  5EGH A;  3T02 A;  4GTZ A;  3IGZ B;  4NWX A;  3MK2 A;  4KJG A;  3WAW A;  4LRD A;  4MHX A;  3DYC A;  3M8Z A;  2GSU A;  2W5R A;  2G9Y A;  3NKN A;  2D1G A;  1EQJ A;  1HDH A;  3BDF A;  4NWJ A;  1SHQ A;  4KM4 A;  3NKO A;  4KJD A;  3TX0 A;  5EGE A;  5LRN A;  3TWZ A;  4LRA A;  1FSU A;  4CXU A;  1ANJ A;  5K4P A;  1EW9 A;  1ELY A;  3M8Y A;  1E2S P;  3T00 A;  5HRT A;  1B8J A;  3TG0 A;  2X98 A;  4GTY A;  1ZED A;  5C66 A;  3A52 A;  4MY4 A;  3IDD A;  2W5S A;  3IGY B;  4FDJ A;  4N7T A;  5L0E A;  3BDG A;  4LQY A;  3WAX A;  2XRG A;  1ALJ A;  1KH9 A;  1EJJ A;  4CYS A;  5GOV A;  2W8D A;  2RH6 A;  4GTX A;  1K7H A;  1KH5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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