1ALJA

Alkaline phosphatase mutant (h412n)
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQENTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Escherichia coli alkaline phosphatase: X-ray structural studies of a mutant enzyme (His-412-->Asn) at one of the catalytically important zinc binding sites.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase (phosphoric monoester)
total genus 164
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aljA00
1AJDA 5IJQA 4UPLA 1AJAA 4YR1A 3OT9A 1EW2A 4LQYA 4QAXA 1N2LA 2GA3A 5L0BA 2VQRA 4LREA 4MHXA 1E3CP 2W5RA 3LXQA 1EI6A 4MY4A 3NKRA 3WAVA 4TN0A 5HRTA 4UOOA 1HJKA 3DPCA 3TWZA 3SZZA 3UO0A 4N7TA 3NVLA 1ZEBA 2RH6A 3BDFA 4MIVA 4CXKA 2GSNA 1P49A 1EQJA 4ZG9A 4UORA 4KJDA 3UN3A 3WBHA 1KHKA 4ZG6A 4ZGAA 1ZEDA 2X98A 4GTWA 3TX0A 3M8YA 3IGYB 4FDJA 2XRGA 4LRBA 4LRDA 4UOPA 5IJSA 1E33P 5LQQA 2W5QA 5GRRA 1N2KA 1KH9A 1Y6VA 4GTYA 4FDIA 3NKQA 1AJBA 2W5VA 4KAVA 5DLWA 2IFYA 4LRFA 5EGHA 4CYSA 4LR7A 2ANHA 1KH5A 1ELZA 3T01A 2D1GA 1EW8A 4LRCA 3WAYA 5TJ3A 1O99A 1E1ZP 3UN5A 1SHNA 1FSUA 2GSUA 3E2DA 3UNYA 4B56A 4GTZA 5AJ9A 3IDDA 3M8WA 4LR2A 1E2SP 3M8ZA 1Y7AA 5K4PA 1KH4A 5LRNA 5L0KA 3BDHA 1HDHA 4KJGA 1SHQA 1B8JA 3MK1A 3NKNA 1ANJA 4CXSA 4KAYA 5INHA 3B5QA 1AJCA 1URBA 1ED9A 3BDGB 4ZG7A 4CXUA 1O98A 4UPKA 1KHLA 5C66A 4GTXA 2W8DA 1ED8A 1K7HA 4NWXA 3SZYA 4CYRA 3MK0A 3NKOA 1HQAA 2W5SA 3A52A 4KM4A 2ZKTA 3NKPA 3IGZB 5GOVA 3M7VA 3NKMA 3ED4A 1ALHA 1ALJA 1ALIA 1EW9A 5KXAA 3TG0A 3DYCA 1ELXA 3KD8A 1ALKA 1KHJA 4LR8A 1ANIA 2W5TA 5LRMA 3WAWA 5DLVA 2G9YA 2QZUA 4UPHA 2GLQA 2W8SA 4LRAA 3BDGA 2XR9A 3T00A 5EGEA 1ZEFA 4LR9A 2W5WA 4UPIA 1AUKA 1EJJA 3Q3QA 5DLTA 3T02A 3UN2A 3CMRA 5L0EA 1ELYA 4NWJA 3WAXA 2IUCA 2GSOA 3MK2A 1KH7A 5LIAA 1KHNA 2W5XA 1URAA 2IUCB
chains in the Genus database with same CATH superfamily
1AJDA 5IJQA 4UPLA 1AJAA 4YR1A 3OT9A 1EW2A 4LQYA 4QAXA 1N2LA 2GA3A 5L0BA 2VQRA 4LREA 4MHXA 1E3CP 2W5RA 3LXQA 1EI6A 4MY4A 3NKRA 3WAVA 4TN0A 5HRTA 4UOOA 1HJKA 3DPCA 3TWZA 3SZZA 3UO0A 4N7TA 3NVLA 1ZEBA 2RH6A 3BDFA 4MIVA 4CXKA 2GSNA 1P49A 1EQJA 4ZG9A 4UORA 4KJDA 3UN3A 3WBHA 1KHKA 4ZG6A 4ZGAA 1ZEDA 2X98A 4GTWA 3TX0A 3M8YA 3IGYB 4FDJA 2XRGA 4LRBA 4LRDA 4UOPA 5IJSA 1E33P 5LQQA 2W5QA 5GRRA 1N2KA 1KH9A 1Y6VA 4GTYA 4FDIA 3NKQA 1AJBA 2W5VA 4KAVA 5DLWA 2IFYA 4LRFA 5EGHA 4CYSA 4LR7A 2ANHA 1KH5A 1ELZA 3T01A 2D1GA 1EW8A 4LRCA 3WAYA 5TJ3A 1O99A 1E1ZP 3UN5A 1SHNA 1FSUA 2GSUA 3E2DA 3UNYA 4B56A 4GTZA 5AJ9A 3IDDA 3M8WA 4LR2A 1E2SP 3M8ZA 1Y7AA 5K4PA 1KH4A 5LRNA 5L0KA 3BDHA 1HDHA 4KJGA 1SHQA 1B8JA 3MK1A 3NKNA 1ANJA 4CXSA 4KAYA 5INHA 3B5QA 1AJCA 1URBA 1ED9A 3BDGB 4ZG7A 4CXUA 1O98A 4UPKA 1KHLA 5C66A 4GTXA 2W8DA 1ED8A 1K7HA 4NWXA 3SZYA 4CYRA 3MK0A 3NKOA 1HQAA 2W5SA 3A52A 4KM4A 2ZKTA 3NKPA 3IGZB 5GOVA 3M7VA 3NKMA 3ED4A 1ALHA 1ALJA 1ALIA 1EW9A 5KXAA 3TG0A 3DYCA 1ELXA 3KD8A 1ALKA 1KHJA 4LR8A 1ANIA 2W5TA 5LRMA 3WAWA 5DLVA 2G9YA 2QZUA 4UPHA 2GLQA 2W8SA 4LRAA 3BDGA 2XR9A 3T00A 5EGEA 1ZEFA 4LR9A 2W5WA 4UPIA 1AUKA 1EJJA 3Q3QA 5DLTA 3T02A 3UN2A 3CMRA 5L0EA 1ELYA 4NWJA 3WAXA 2IUCA 2GSOA 3MK2A 1KH7A 5LIAA 1KHNA 2W5XA 1URAA 2IUCB
chains in the Genus database with same CATH topology
1AJDA 5IJQA 4UPLA 1AJAA 4YR1A 3OT9A 1EW2A 4LQYA 4QAXA 1N2LA 2GA3A 5L0BA 2VQRA 4LREA 4MHXA 1E3CP 2W5RA 3LXQA 1EI6A 4MY4A 3NKRA 3WAVA 4TN0A 5HRTA 4UOOA 1HJKA 3DPCA 3TWZA 3SZZA 3UO0A 4N7TA 3NVLA 1ZEBA 2RH6A 3BDFA 4MIVA 4CXKA 2GSNA 1P49A 1EQJA 4ZG9A 4UORA 4KJDA 3UN3A 3WBHA 1KHKA 4ZG6A 4ZGAA 1ZEDA 2X98A 4GTWA 3TX0A 3M8YA 3IGYB 4FDJA 2XRGA 4LRBA 4LRDA 4UOPA 5IJSA 1E33P 5LQQA 2W5QA 5GRRA 1N2KA 1KH9A 1Y6VA 4GTYA 4FDIA 3NKQA 1AJBA 2W5VA 4KAVA 5DLWA 2IFYA 4LRFA 5EGHA 4CYSA 4LR7A 2ANHA 1KH5A 1ELZA 3T01A 2D1GA 1EW8A 4LRCA 3WAYA 5TJ3A 1O99A 1E1ZP 3UN5A 1SHNA 1FSUA 2GSUA 3E2DA 3UNYA 4B56A 4GTZA 5AJ9A 3IDDA 3M8WA 4LR2A 1E2SP 3M8ZA 1Y7AA 5K4PA 1KH4A 5LRNA 5L0KA 3BDHA 1HDHA 4KJGA 1SHQA 1B8JA 3MK1A 3NKNA 1ANJA 4CXSA 4KAYA 5INHA 3B5QA 1AJCA 1URBA 1ED9A 3BDGB 4ZG7A 4CXUA 1O98A 4UPKA 1KHLA 5C66A 4GTXA 2W8DA 1ED8A 1K7HA 4NWXA 3SZYA 4CYRA 3MK0A 3NKOA 1HQAA 2W5SA 3A52A 4KM4A 2ZKTA 3NKPA 3IGZB 5GOVA 3M7VA 3NKMA 3ED4A 1ALHA 1ALJA 1ALIA 1EW9A 5KXAA 3TG0A 3DYCA 1ELXA 3KD8A 1ALKA 1KHJA 4LR8A 1ANIA 2W5TA 5LRMA 3WAWA 5DLVA 2G9YA 2QZUA 4UPHA 2GLQA 2W8SA 4LRAA 3BDGA 2XR9A 3T00A 5EGEA 1ZEFA 4LR9A 2W5WA 4UPIA 1AUKA 1EJJA 3Q3QA 5DLTA 3T02A 3UN2A 3CMRA 5L0EA 1ELYA 4NWJA 3WAXA 2IUCA 2GSOA 3MK2A 1KH7A 5LIAA 1KHNA 2W5XA 1URAA 2IUCB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJD A;  5IJQ A;  4UPL A;  1AJA A;  4YR1 A;  3OT9 A;  1EW2 A;  4LQY A;  4QAX A;  1N2L A;  2GA3 A;  5L0B A;  2VQR A;  4LRE A;  4MHX A;  1E3C P;  2W5R A;  3LXQ A;  1EI6 A;  4MY4 A;  3NKR A;  3WAV A;  4TN0 A;  5HRT A;  4UOO A;  1HJK A;  3DPC A;  3TWZ A;  3SZZ A;  3UO0 A;  4N7T A;  3NVL A;  1ZEB A;  2RH6 A;  3BDF A;  4MIV A;  4CXK A;  2GSN A;  1P49 A;  1EQJ A;  4ZG9 A;  4UOR A;  4KJD A;  3UN3 A;  3WBH A;  1KHK A;  4ZG6 A;  4ZGA A;  1ZED A;  2X98 A;  4GTW A;  3TX0 A;  3M8Y A;  3IGY B;  4FDJ A;  2XRG A;  4LRB A;  4LRD A;  4UOP A;  5IJS A;  1E33 P;  5LQQ A;  2W5Q A;  5GRR A;  1N2K A;  1KH9 A;  1Y6V A;  4GTY A;  4FDI A;  3NKQ A;  1AJB A;  2W5V A;  4KAV A;  5DLW A;  2IFY A;  4LRF A;  5EGH A;  4CYS A;  4LR7 A;  2ANH A;  1KH5 A;  1ELZ A;  3T01 A;  2D1G A;  1EW8 A;  4LRC A;  3WAY A;  5TJ3 A;  1O99 A;  1E1Z P;  3UN5 A;  1SHN A;  1FSU A;  2GSU A;  3E2D A;  3UNY A;  4B56 A;  4GTZ A;  5AJ9 A;  3IDD A;  3M8W A;  4LR2 A;  1E2S P;  3M8Z A;  1Y7A A;  5K4P A;  1KH4 A;  5LRN A;  5L0K A;  3BDH A;  1HDH A;  4KJG A;  1SHQ A;  1B8J A;  3MK1 A;  3NKN A;  1ANJ A;  4CXS A;  4KAY A;  5INH A;  3B5Q A;  1AJC A;  1URB A;  1ED9 A;  3BDG B;  4ZG7 A;  4CXU A;  1O98 A;  4UPK A;  1KHL A;  5C66 A;  4GTX A;  2W8D A;  1ED8 A;  1K7H A;  4NWX A;  3SZY A;  4CYR A;  3MK0 A;  3NKO A;  1HQA A;  2W5S A;  3A52 A;  4KM4 A;  2ZKT A;  3NKP A;  3IGZ B;  5GOV A;  3M7V A;  3NKM A;  3ED4 A;  1ALH A;  1ALJ A;  1ALI A;  1EW9 A;  5KXA A;  3TG0 A;  3DYC A;  1ELX A;  3KD8 A;  1ALK A;  1KHJ A;  4LR8 A;  1ANI A;  2W5T A;  5LRM A;  3WAW A;  5DLV A;  2G9Y A;  2QZU A;  4UPH A;  2GLQ A;  2W8S A;  4LRA A;  3BDG A;  2XR9 A;  3T00 A;  5EGE A;  1ZEF A;  4LR9 A;  2W5W A;  4UPI A;  1AUK A;  1EJJ A;  3Q3Q A;  5DLT A;  3T02 A;  3UN2 A;  3CMR A;  5L0E A;  1ELY A;  4NWJ A;  3WAX A;  2IUC A;  2GSO A;  3MK2 A;  1KH7 A;  5LIA A;  1KHN A;  2W5X A;  1URA A;  2IUC B; 
#chains in the Genus database with same CATH topology
 1AJD A;  5IJQ A;  4UPL A;  1AJA A;  4YR1 A;  3OT9 A;  1EW2 A;  4LQY A;  4QAX A;  1N2L A;  2GA3 A;  5L0B A;  2VQR A;  4LRE A;  4MHX A;  1E3C P;  2W5R A;  3LXQ A;  1EI6 A;  4MY4 A;  3NKR A;  3WAV A;  4TN0 A;  5HRT A;  4UOO A;  1HJK A;  3DPC A;  3TWZ A;  3SZZ A;  3UO0 A;  4N7T A;  3NVL A;  1ZEB A;  2RH6 A;  3BDF A;  4MIV A;  4CXK A;  2GSN A;  1P49 A;  1EQJ A;  4ZG9 A;  4UOR A;  4KJD A;  3UN3 A;  3WBH A;  1KHK A;  4ZG6 A;  4ZGA A;  1ZED A;  2X98 A;  4GTW A;  3TX0 A;  3M8Y A;  3IGY B;  4FDJ A;  2XRG A;  4LRB A;  4LRD A;  4UOP A;  5IJS A;  1E33 P;  5LQQ A;  2W5Q A;  5GRR A;  1N2K A;  1KH9 A;  1Y6V A;  4GTY A;  4FDI A;  3NKQ A;  1AJB A;  2W5V A;  4KAV A;  5DLW A;  2IFY A;  4LRF A;  5EGH A;  4CYS A;  4LR7 A;  2ANH A;  1KH5 A;  1ELZ A;  3T01 A;  2D1G A;  1EW8 A;  4LRC A;  3WAY A;  5TJ3 A;  1O99 A;  1E1Z P;  3UN5 A;  1SHN A;  1FSU A;  2GSU A;  3E2D A;  3UNY A;  4B56 A;  4GTZ A;  5AJ9 A;  3IDD A;  3M8W A;  4LR2 A;  1E2S P;  3M8Z A;  1Y7A A;  5K4P A;  1KH4 A;  5LRN A;  5L0K A;  3BDH A;  1HDH A;  4KJG A;  1SHQ A;  1B8J A;  3MK1 A;  3NKN A;  1ANJ A;  4CXS A;  4KAY A;  5INH A;  3B5Q A;  1AJC A;  1URB A;  1ED9 A;  3BDG B;  4ZG7 A;  4CXU A;  1O98 A;  4UPK A;  1KHL A;  5C66 A;  4GTX A;  2W8D A;  1ED8 A;  1K7H A;  4NWX A;  3SZY A;  4CYR A;  3MK0 A;  3NKO A;  1HQA A;  2W5S A;  3A52 A;  4KM4 A;  2ZKT A;  3NKP A;  3IGZ B;  5GOV A;  3M7V A;  3NKM A;  3ED4 A;  1ALH A;  1ALJ A;  1ALI A;  1EW9 A;  5KXA A;  3TG0 A;  3DYC A;  1ELX A;  3KD8 A;  1ALK A;  1KHJ A;  4LR8 A;  1ANI A;  2W5T A;  5LRM A;  3WAW A;  5DLV A;  2G9Y A;  2QZU A;  4UPH A;  2GLQ A;  2W8S A;  4LRA A;  3BDG A;  2XR9 A;  3T00 A;  5EGE A;  1ZEF A;  4LR9 A;  2W5W A;  4UPI A;  1AUK A;  1EJJ A;  3Q3Q A;  5DLT A;  3T02 A;  3UN2 A;  3CMR A;  5L0E A;  1ELY A;  4NWJ A;  3WAX A;  2IUC A;  2GSO A;  3MK2 A;  1KH7 A;  5LIA A;  1KHN A;  2W5X A;  1URA A;  2IUC B; 
#chains in the Genus database with same CATH homology
 1AJD A;  5IJQ A;  4UPL A;  1AJA A;  4YR1 A;  3OT9 A;  1EW2 A;  4LQY A;  4QAX A;  1N2L A;  2GA3 A;  5L0B A;  2VQR A;  4LRE A;  4MHX A;  1E3C P;  2W5R A;  3LXQ A;  1EI6 A;  4MY4 A;  3NKR A;  3WAV A;  4TN0 A;  5HRT A;  4UOO A;  1HJK A;  3DPC A;  3TWZ A;  3SZZ A;  3UO0 A;  4N7T A;  3NVL A;  1ZEB A;  2RH6 A;  3BDF A;  4MIV A;  4CXK A;  2GSN A;  1P49 A;  1EQJ A;  4ZG9 A;  4UOR A;  4KJD A;  3UN3 A;  3WBH A;  1KHK A;  4ZG6 A;  4ZGA A;  1ZED A;  2X98 A;  4GTW A;  3TX0 A;  3M8Y A;  3IGY B;  4FDJ A;  2XRG A;  4LRB A;  4LRD A;  4UOP A;  5IJS A;  1E33 P;  5LQQ A;  2W5Q A;  5GRR A;  1N2K A;  1KH9 A;  1Y6V A;  4GTY A;  4FDI A;  3NKQ A;  1AJB A;  2W5V A;  4KAV A;  5DLW A;  2IFY A;  4LRF A;  5EGH A;  4CYS A;  4LR7 A;  2ANH A;  1KH5 A;  1ELZ A;  3T01 A;  2D1G A;  1EW8 A;  4LRC A;  3WAY A;  5TJ3 A;  1O99 A;  1E1Z P;  3UN5 A;  1SHN A;  1FSU A;  2GSU A;  3E2D A;  3UNY A;  4B56 A;  4GTZ A;  5AJ9 A;  3IDD A;  3M8W A;  4LR2 A;  1E2S P;  3M8Z A;  1Y7A A;  5K4P A;  1KH4 A;  5LRN A;  5L0K A;  3BDH A;  1HDH A;  4KJG A;  1SHQ A;  1B8J A;  3MK1 A;  3NKN A;  1ANJ A;  4CXS A;  4KAY A;  5INH A;  3B5Q A;  1AJC A;  1URB A;  1ED9 A;  3BDG B;  4ZG7 A;  4CXU A;  1O98 A;  4UPK A;  1KHL A;  5C66 A;  4GTX A;  2W8D A;  1ED8 A;  1K7H A;  4NWX A;  3SZY A;  4CYR A;  3MK0 A;  3NKO A;  1HQA A;  2W5S A;  3A52 A;  4KM4 A;  2ZKT A;  3NKP A;  3IGZ B;  5GOV A;  3M7V A;  3NKM A;  3ED4 A;  1ALH A;  1ALJ A;  1ALI A;  1EW9 A;  5KXA A;  3TG0 A;  3DYC A;  1ELX A;  3KD8 A;  1ALK A;  1KHJ A;  4LR8 A;  1ANI A;  2W5T A;  5LRM A;  3WAW A;  5DLV A;  2G9Y A;  2QZU A;  4UPH A;  2GLQ A;  2W8S A;  4LRA A;  3BDG A;  2XR9 A;  3T00 A;  5EGE A;  1ZEF A;  4LR9 A;  2W5W A;  4UPI A;  1AUK A;  1EJJ A;  3Q3Q A;  5DLT A;  3T02 A;  3UN2 A;  3CMR A;  5L0E A;  1ELY A;  4NWJ A;  3WAX A;  2IUC A;  2GSO A;  3MK2 A;  1KH7 A;  5LIA A;  1KHN A;  2W5X A;  1URA A;  2IUC B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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