1ELZA

E. coli alkaline phosphatase mutant (s102g)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDGAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elzA00
4GTYA 1Y6VA 3UN2A 4ZG7A 4LR2A 2QZUA 2W5VA 4LRCA 3ED4A 3UO0A 5KXAA 1Y7AA 3BDHA 3WBHA 4UPLA 2IUCB 4LRDA 1KH5A 5HRTA 2W5SA 4CYSA 1ALIA 2W8DA 4LR7A 5DLTA 3TG0A 1ELYA 2XRGA 1E3CP 1E1ZP 4LRAA 3M8ZA 2ANHA 3BDGA 3DYCA 1ANIA 1KHKA 3WAXA 3MK1A 1N2KA 4LR8A 4UPHA 4CYRA 1B8JA 5EGHA 5IJSA 4LRBA 1EW2A 4LR9A 1AJCA 1K7HA 3IGZB 4ZG9A 1E2SP 5C66A 4UOOA 2W5QA 4UPKA 5L0EA 1KH4A 3NKPA 2W5XA 4GTXA 3SZZA 1ZEDA 3Q3QA 1ZEBA 1ALHA 3TX0A 3UNYA 3TWZA 1ANJA 1KHNA 4MHXA 1EQJA 3DPCA 5EGEA 1KH9A 3WAYA 4FDIA 3M7VA 4NWXA 2IFYA 3T01A 3UN3A 5LRNA 1ED9A 4UPIA 1URBA 4ZGAA 2RH6A 1KHLA 3WAVA 1EI6A 4MY4A 5L0KA 3BDFA 4CXKA 3WAWA 3NKMA 2VQRA 1ED8A 5AJ9A 3T02A 3LXQA 2W5WA 3T00A 4UORA 3KD8A 1E33P 4KM4A 4GTWA 4ZG6A 1AJAA 1URAA 3A52A 2D1GA 5K4PA 1AJBA 3CMRA 5IJQA 4LQYA 3OT9A 1O98A 1AUKA 4FDJA 1FSUA 1HJKA 2ZKTA 4NWJA 2GLQA 5INHA 4CXSA 4LREA 1ELZA 3NVLA 3BDGB 3SZYA 1AJDA 5TJ3A 2GSNA 4B56A 5LIAA 1KHJA 1O99A 1HQAA 2XR9A 5LQQA 1EJJA 1ELXA 1N2LA 3NKOA 2W5TA 4GTZA 4CXUA 1SHQA 2W5RA 2GSOA 5DLVA 1EW8A 4QAXA 4N7TA 1KH7A 4TN0A 3UN5A 3M8YA 1ZEFA 5L0BA 3E2DA 1EW9A 5DLWA 2G9YA 3IDDA 3NKNA 3MK0A 2GA3A 2IUCA 4UOPA 3IGYB 4YR1A 1ALJA 3MK2A 3M8WA 1ALKA 4KJDA 1SHNA 5GRRA 5LRMA 1P49A 2GSUA 2W8SA 4KAVA 4KJGA 4KAYA 4LRFA 3NKRA 1HDHA 3B5QA 4MIVA 5GOVA 3NKQA 2X98A
chains in the Genus database with same CATH superfamily
4GTYA 1Y6VA 3UN2A 4ZG7A 4LR2A 2QZUA 2W5VA 4LRCA 3ED4A 3UO0A 5KXAA 1Y7AA 3BDHA 3WBHA 4UPLA 2IUCB 4LRDA 1KH5A 5HRTA 2W5SA 4CYSA 1ALIA 2W8DA 4LR7A 5DLTA 3TG0A 1ELYA 2XRGA 1E3CP 1E1ZP 4LRAA 3M8ZA 2ANHA 3BDGA 3DYCA 1ANIA 1KHKA 3WAXA 3MK1A 1N2KA 4LR8A 4UPHA 4CYRA 1B8JA 5EGHA 5IJSA 4LRBA 1EW2A 4LR9A 1AJCA 1K7HA 3IGZB 4ZG9A 1E2SP 5C66A 4UOOA 2W5QA 4UPKA 5L0EA 1KH4A 3NKPA 2W5XA 4GTXA 3SZZA 1ZEDA 3Q3QA 1ZEBA 1ALHA 3TX0A 3UNYA 3TWZA 1ANJA 1KHNA 4MHXA 1EQJA 3DPCA 5EGEA 1KH9A 3WAYA 4FDIA 3M7VA 4NWXA 2IFYA 3T01A 3UN3A 5LRNA 1ED9A 4UPIA 1URBA 4ZGAA 2RH6A 1KHLA 3WAVA 1EI6A 4MY4A 5L0KA 3BDFA 4CXKA 3WAWA 3NKMA 2VQRA 1ED8A 5AJ9A 3T02A 3LXQA 2W5WA 3T00A 4UORA 3KD8A 1E33P 4KM4A 4GTWA 4ZG6A 1AJAA 1URAA 3A52A 2D1GA 5K4PA 1AJBA 3CMRA 5IJQA 4LQYA 3OT9A 1O98A 1AUKA 4FDJA 1FSUA 1HJKA 2ZKTA 4NWJA 2GLQA 5INHA 4CXSA 4LREA 1ELZA 3NVLA 3BDGB 3SZYA 1AJDA 5TJ3A 2GSNA 4B56A 5LIAA 1KHJA 1O99A 1HQAA 2XR9A 5LQQA 1EJJA 1ELXA 1N2LA 3NKOA 2W5TA 4GTZA 4CXUA 1SHQA 2W5RA 2GSOA 5DLVA 1EW8A 4QAXA 4N7TA 1KH7A 4TN0A 3UN5A 3M8YA 1ZEFA 5L0BA 3E2DA 1EW9A 5DLWA 2G9YA 3IDDA 3NKNA 3MK0A 2GA3A 2IUCA 4UOPA 3IGYB 4YR1A 1ALJA 3MK2A 3M8WA 1ALKA 4KJDA 1SHNA 5GRRA 5LRMA 1P49A 2GSUA 2W8SA 4KAVA 4KJGA 4KAYA 4LRFA 3NKRA 1HDHA 3B5QA 4MIVA 5GOVA 3NKQA 2X98A
chains in the Genus database with same CATH topology
4GTYA 1Y6VA 3UN2A 4ZG7A 4LR2A 2QZUA 2W5VA 4LRCA 3ED4A 3UO0A 5KXAA 1Y7AA 3BDHA 3WBHA 4UPLA 2IUCB 4LRDA 1KH5A 5HRTA 2W5SA 4CYSA 1ALIA 2W8DA 4LR7A 5DLTA 3TG0A 1ELYA 2XRGA 1E3CP 1E1ZP 4LRAA 3M8ZA 2ANHA 3BDGA 3DYCA 1ANIA 1KHKA 3WAXA 3MK1A 1N2KA 4LR8A 4UPHA 4CYRA 1B8JA 5EGHA 5IJSA 4LRBA 1EW2A 4LR9A 1AJCA 1K7HA 3IGZB 4ZG9A 1E2SP 5C66A 4UOOA 2W5QA 4UPKA 5L0EA 1KH4A 3NKPA 2W5XA 4GTXA 3SZZA 1ZEDA 3Q3QA 1ZEBA 1ALHA 3TX0A 3UNYA 3TWZA 1ANJA 1KHNA 4MHXA 1EQJA 3DPCA 5EGEA 1KH9A 3WAYA 4FDIA 3M7VA 4NWXA 2IFYA 3T01A 3UN3A 5LRNA 1ED9A 4UPIA 1URBA 4ZGAA 2RH6A 1KHLA 3WAVA 1EI6A 4MY4A 5L0KA 3BDFA 4CXKA 3WAWA 3NKMA 2VQRA 1ED8A 5AJ9A 3T02A 3LXQA 2W5WA 3T00A 4UORA 3KD8A 1E33P 4KM4A 4GTWA 4ZG6A 1AJAA 1URAA 3A52A 2D1GA 5K4PA 1AJBA 3CMRA 5IJQA 4LQYA 3OT9A 1O98A 1AUKA 4FDJA 1FSUA 1HJKA 2ZKTA 4NWJA 2GLQA 5INHA 4CXSA 4LREA 1ELZA 3NVLA 3BDGB 3SZYA 1AJDA 5TJ3A 2GSNA 4B56A 5LIAA 1KHJA 1O99A 1HQAA 2XR9A 5LQQA 1EJJA 1ELXA 1N2LA 3NKOA 2W5TA 4GTZA 4CXUA 1SHQA 2W5RA 2GSOA 5DLVA 1EW8A 4QAXA 4N7TA 1KH7A 4TN0A 3UN5A 3M8YA 1ZEFA 5L0BA 3E2DA 1EW9A 5DLWA 2G9YA 3IDDA 3NKNA 3MK0A 2GA3A 2IUCA 4UOPA 3IGYB 4YR1A 1ALJA 3MK2A 3M8WA 1ALKA 4KJDA 1SHNA 5GRRA 5LRMA 1P49A 2GSUA 2W8SA 4KAVA 4KJGA 4KAYA 4LRFA 3NKRA 1HDHA 3B5QA 4MIVA 5GOVA 3NKQA 2X98A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTY A;  1Y6V A;  3UN2 A;  4ZG7 A;  4LR2 A;  2QZU A;  2W5V A;  4LRC A;  3ED4 A;  3UO0 A;  5KXA A;  1Y7A A;  3BDH A;  3WBH A;  4UPL A;  2IUC B;  4LRD A;  1KH5 A;  5HRT A;  2W5S A;  4CYS A;  1ALI A;  2W8D A;  4LR7 A;  5DLT A;  3TG0 A;  1ELY A;  2XRG A;  1E3C P;  1E1Z P;  4LRA A;  3M8Z A;  2ANH A;  3BDG A;  3DYC A;  1ANI A;  1KHK A;  3WAX A;  3MK1 A;  1N2K A;  4LR8 A;  4UPH A;  4CYR A;  1B8J A;  5EGH A;  5IJS A;  4LRB A;  1EW2 A;  4LR9 A;  1AJC A;  1K7H A;  3IGZ B;  4ZG9 A;  1E2S P;  5C66 A;  4UOO A;  2W5Q A;  4UPK A;  5L0E A;  1KH4 A;  3NKP A;  2W5X A;  4GTX A;  3SZZ A;  1ZED A;  3Q3Q A;  1ZEB A;  1ALH A;  3TX0 A;  3UNY A;  3TWZ A;  1ANJ A;  1KHN A;  4MHX A;  1EQJ A;  3DPC A;  5EGE A;  1KH9 A;  3WAY A;  4FDI A;  3M7V A;  4NWX A;  2IFY A;  3T01 A;  3UN3 A;  5LRN A;  1ED9 A;  4UPI A;  1URB A;  4ZGA A;  2RH6 A;  1KHL A;  3WAV A;  1EI6 A;  4MY4 A;  5L0K A;  3BDF A;  4CXK A;  3WAW A;  3NKM A;  2VQR A;  1ED8 A;  5AJ9 A;  3T02 A;  3LXQ A;  2W5W A;  3T00 A;  4UOR A;  3KD8 A;  1E33 P;  4KM4 A;  4GTW A;  4ZG6 A;  1AJA A;  1URA A;  3A52 A;  2D1G A;  5K4P A;  1AJB A;  3CMR A;  5IJQ A;  4LQY A;  3OT9 A;  1O98 A;  1AUK A;  4FDJ A;  1FSU A;  1HJK A;  2ZKT A;  4NWJ A;  2GLQ A;  5INH A;  4CXS A;  4LRE A;  1ELZ A;  3NVL A;  3BDG B;  3SZY A;  1AJD A;  5TJ3 A;  2GSN A;  4B56 A;  5LIA A;  1KHJ A;  1O99 A;  1HQA A;  2XR9 A;  5LQQ A;  1EJJ A;  1ELX A;  1N2L A;  3NKO A;  2W5T A;  4GTZ A;  4CXU A;  1SHQ A;  2W5R A;  2GSO A;  5DLV A;  1EW8 A;  4QAX A;  4N7T A;  1KH7 A;  4TN0 A;  3UN5 A;  3M8Y A;  1ZEF A;  5L0B A;  3E2D A;  1EW9 A;  5DLW A;  2G9Y A;  3IDD A;  3NKN A;  3MK0 A;  2GA3 A;  2IUC A;  4UOP A;  3IGY B;  4YR1 A;  1ALJ A;  3MK2 A;  3M8W A;  1ALK A;  4KJD A;  1SHN A;  5GRR A;  5LRM A;  1P49 A;  2GSU A;  2W8S A;  4KAV A;  4KJG A;  4KAY A;  4LRF A;  3NKR A;  1HDH A;  3B5Q A;  4MIV A;  5GOV A;  3NKQ A;  2X98 A; 
#chains in the Genus database with same CATH topology
 4GTY A;  1Y6V A;  3UN2 A;  4ZG7 A;  4LR2 A;  2QZU A;  2W5V A;  4LRC A;  3ED4 A;  3UO0 A;  5KXA A;  1Y7A A;  3BDH A;  3WBH A;  4UPL A;  2IUC B;  4LRD A;  1KH5 A;  5HRT A;  2W5S A;  4CYS A;  1ALI A;  2W8D A;  4LR7 A;  5DLT A;  3TG0 A;  1ELY A;  2XRG A;  1E3C P;  1E1Z P;  4LRA A;  3M8Z A;  2ANH A;  3BDG A;  3DYC A;  1ANI A;  1KHK A;  3WAX A;  3MK1 A;  1N2K A;  4LR8 A;  4UPH A;  4CYR A;  1B8J A;  5EGH A;  5IJS A;  4LRB A;  1EW2 A;  4LR9 A;  1AJC A;  1K7H A;  3IGZ B;  4ZG9 A;  1E2S P;  5C66 A;  4UOO A;  2W5Q A;  4UPK A;  5L0E A;  1KH4 A;  3NKP A;  2W5X A;  4GTX A;  3SZZ A;  1ZED A;  3Q3Q A;  1ZEB A;  1ALH A;  3TX0 A;  3UNY A;  3TWZ A;  1ANJ A;  1KHN A;  4MHX A;  1EQJ A;  3DPC A;  5EGE A;  1KH9 A;  3WAY A;  4FDI A;  3M7V A;  4NWX A;  2IFY A;  3T01 A;  3UN3 A;  5LRN A;  1ED9 A;  4UPI A;  1URB A;  4ZGA A;  2RH6 A;  1KHL A;  3WAV A;  1EI6 A;  4MY4 A;  5L0K A;  3BDF A;  4CXK A;  3WAW A;  3NKM A;  2VQR A;  1ED8 A;  5AJ9 A;  3T02 A;  3LXQ A;  2W5W A;  3T00 A;  4UOR A;  3KD8 A;  1E33 P;  4KM4 A;  4GTW A;  4ZG6 A;  1AJA A;  1URA A;  3A52 A;  2D1G A;  5K4P A;  1AJB A;  3CMR A;  5IJQ A;  4LQY A;  3OT9 A;  1O98 A;  1AUK A;  4FDJ A;  1FSU A;  1HJK A;  2ZKT A;  4NWJ A;  2GLQ A;  5INH A;  4CXS A;  4LRE A;  1ELZ A;  3NVL A;  3BDG B;  3SZY A;  1AJD A;  5TJ3 A;  2GSN A;  4B56 A;  5LIA A;  1KHJ A;  1O99 A;  1HQA A;  2XR9 A;  5LQQ A;  1EJJ A;  1ELX A;  1N2L A;  3NKO A;  2W5T A;  4GTZ A;  4CXU A;  1SHQ A;  2W5R A;  2GSO A;  5DLV A;  1EW8 A;  4QAX A;  4N7T A;  1KH7 A;  4TN0 A;  3UN5 A;  3M8Y A;  1ZEF A;  5L0B A;  3E2D A;  1EW9 A;  5DLW A;  2G9Y A;  3IDD A;  3NKN A;  3MK0 A;  2GA3 A;  2IUC A;  4UOP A;  3IGY B;  4YR1 A;  1ALJ A;  3MK2 A;  3M8W A;  1ALK A;  4KJD A;  1SHN A;  5GRR A;  5LRM A;  1P49 A;  2GSU A;  2W8S A;  4KAV A;  4KJG A;  4KAY A;  4LRF A;  3NKR A;  1HDH A;  3B5Q A;  4MIV A;  5GOV A;  3NKQ A;  2X98 A; 
#chains in the Genus database with same CATH homology
 4GTY A;  1Y6V A;  3UN2 A;  4ZG7 A;  4LR2 A;  2QZU A;  2W5V A;  4LRC A;  3ED4 A;  3UO0 A;  5KXA A;  1Y7A A;  3BDH A;  3WBH A;  4UPL A;  2IUC B;  4LRD A;  1KH5 A;  5HRT A;  2W5S A;  4CYS A;  1ALI A;  2W8D A;  4LR7 A;  5DLT A;  3TG0 A;  1ELY A;  2XRG A;  1E3C P;  1E1Z P;  4LRA A;  3M8Z A;  2ANH A;  3BDG A;  3DYC A;  1ANI A;  1KHK A;  3WAX A;  3MK1 A;  1N2K A;  4LR8 A;  4UPH A;  4CYR A;  1B8J A;  5EGH A;  5IJS A;  4LRB A;  1EW2 A;  4LR9 A;  1AJC A;  1K7H A;  3IGZ B;  4ZG9 A;  1E2S P;  5C66 A;  4UOO A;  2W5Q A;  4UPK A;  5L0E A;  1KH4 A;  3NKP A;  2W5X A;  4GTX A;  3SZZ A;  1ZED A;  3Q3Q A;  1ZEB A;  1ALH A;  3TX0 A;  3UNY A;  3TWZ A;  1ANJ A;  1KHN A;  4MHX A;  1EQJ A;  3DPC A;  5EGE A;  1KH9 A;  3WAY A;  4FDI A;  3M7V A;  4NWX A;  2IFY A;  3T01 A;  3UN3 A;  5LRN A;  1ED9 A;  4UPI A;  1URB A;  4ZGA A;  2RH6 A;  1KHL A;  3WAV A;  1EI6 A;  4MY4 A;  5L0K A;  3BDF A;  4CXK A;  3WAW A;  3NKM A;  2VQR A;  1ED8 A;  5AJ9 A;  3T02 A;  3LXQ A;  2W5W A;  3T00 A;  4UOR A;  3KD8 A;  1E33 P;  4KM4 A;  4GTW A;  4ZG6 A;  1AJA A;  1URA A;  3A52 A;  2D1G A;  5K4P A;  1AJB A;  3CMR A;  5IJQ A;  4LQY A;  3OT9 A;  1O98 A;  1AUK A;  4FDJ A;  1FSU A;  1HJK A;  2ZKT A;  4NWJ A;  2GLQ A;  5INH A;  4CXS A;  4LRE A;  1ELZ A;  3NVL A;  3BDG B;  3SZY A;  1AJD A;  5TJ3 A;  2GSN A;  4B56 A;  5LIA A;  1KHJ A;  1O99 A;  1HQA A;  2XR9 A;  5LQQ A;  1EJJ A;  1ELX A;  1N2L A;  3NKO A;  2W5T A;  4GTZ A;  4CXU A;  1SHQ A;  2W5R A;  2GSO A;  5DLV A;  1EW8 A;  4QAX A;  4N7T A;  1KH7 A;  4TN0 A;  3UN5 A;  3M8Y A;  1ZEF A;  5L0B A;  3E2D A;  1EW9 A;  5DLW A;  2G9Y A;  3IDD A;  3NKN A;  3MK0 A;  2GA3 A;  2IUC A;  4UOP A;  3IGY B;  4YR1 A;  1ALJ A;  3MK2 A;  3M8W A;  1ALK A;  4KJD A;  1SHN A;  5GRR A;  5LRM A;  1P49 A;  2GSU A;  2W8S A;  4KAV A;  4KJG A;  4KAY A;  4LRF A;  3NKR A;  1HDH A;  3B5Q A;  4MIV A;  5GOV A;  3NKQ A;  2X98 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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