1ELZA

E. coli alkaline phosphatase mutant (s102g)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDGAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elzA00
1AJAA 2G9YA 4GTZA 2XR9A 3MK1A 4MY4A 2W5XA 4B56A 5C66A 1ZEBA 3SZYA 4LR8A 1O98A 2ZKTA 1KHLA 5GOVA 1AJDA 3NKMA 4CXKA 1E2SP 4KAVA 4KJDA 4UOOA 5DLVA 4GTWA 1HDHA 1KHJA 5LQQA 1EI6A 1ED9A 1URAA 1P49A 3BDHA 1SHQA 2W5WA 3UNYA 1HQAA 2RH6A 1KH7A 1ED8A 1EW8A 1ZEDA 3MK2A 1ELZA 4UPHA 1K7HA 3BDFA 1EQJA 3DPCA 1SHNA 3SZZA 1E3CP 1ANIA 5HRTA 2XRGA 3B5QA 4LR2A 5EGHA 4NWJA 4UOPA 5INHA 2GLQA 3OT9A 5LRNA 3UN5A 2GSUA 1ALJA 1E1ZP 1KH5A 3E2DA 3NKNA 3IGZB 3LXQA 2W5TA 3M8YA 4LR7A 5DLTA 3WBHA 3KD8A 3MK0A 5AJ9A 4NWXA 2IUCB 2W8SA 4LRAA 4QAXA 4UPLA 3Q3QA 1KHKA 5IJQA 1URBA 5K4PA 3TX0A 5IJSA 3M7VA 3M8ZA 1E33P 1B8JA 3BDGB 3UN3A 1KH9A 4TN0A 4KJGA 2IUCA 2GSNA 4CYRA 3NVLA 1ELXA 1O99A 1ZEFA 1N2LA 4FDIA 4KM4A 4N7TA 4UPIA 4MIVA 3T01A 1ALKA 3UO0A 2W8DA 2W5SA 5EGEA 1N2KA 3NKOA 2D1GA 3WAVA 3DYCA 3BDGA 1ANJA 3T02A 2GA3A 3T00A 3WAWA 3NKRA 5TJ3A 2VQRA 2W5RA 2X98A 2IFYA 4ZGAA 5L0BA 2W5QA 2GSOA 4ZG6A 3IGYB 3CMRA 2W5VA 4MHXA 5GRRA 3NKPA 5DLWA 3IDDA 1ALHA 1ALIA 1FSUA 3WAYA 5L0KA 4ZG9A 3UN2A 3M8WA 1EJJA 1KHNA 4YR1A 1ELYA 2QZUA 4FDJA 1KH4A 1Y7AA 4CYSA 1HJKA 4LRCA 3NKQA 4GTXA 4KAYA 3WAXA 3A52A 3TWZA 4CXUA 2ANHA 5LRMA 5LIAA 1AJBA 4ZG7A 5KXAA 4LR9A 4UORA 3TG0A 3ED4A 1EW2A 4LQYA 1Y6VA 4LRDA 4LRFA 4CXSA 4LRBA 4LREA 1AJCA 1AUKA 4UPKA 5L0EA 1EW9A 4GTYA
chains in the Genus database with same CATH superfamily
1AJAA 2G9YA 4GTZA 2XR9A 3MK1A 4MY4A 2W5XA 4B56A 5C66A 1ZEBA 3SZYA 4LR8A 1O98A 2ZKTA 1KHLA 5GOVA 1AJDA 3NKMA 4CXKA 1E2SP 4KAVA 4KJDA 4UOOA 5DLVA 4GTWA 1HDHA 1KHJA 5LQQA 1EI6A 1ED9A 1URAA 1P49A 3BDHA 1SHQA 2W5WA 3UNYA 1HQAA 2RH6A 1KH7A 1ED8A 1EW8A 1ZEDA 3MK2A 1ELZA 4UPHA 1K7HA 3BDFA 1EQJA 3DPCA 1SHNA 3SZZA 1E3CP 1ANIA 5HRTA 2XRGA 3B5QA 4LR2A 5EGHA 4NWJA 4UOPA 5INHA 2GLQA 3OT9A 5LRNA 3UN5A 2GSUA 1ALJA 1E1ZP 1KH5A 3E2DA 3NKNA 3IGZB 3LXQA 2W5TA 3M8YA 4LR7A 5DLTA 3WBHA 3KD8A 3MK0A 5AJ9A 4NWXA 2IUCB 2W8SA 4LRAA 4QAXA 4UPLA 3Q3QA 1KHKA 5IJQA 1URBA 5K4PA 3TX0A 5IJSA 3M7VA 3M8ZA 1E33P 1B8JA 3BDGB 3UN3A 1KH9A 4TN0A 4KJGA 2IUCA 2GSNA 4CYRA 3NVLA 1ELXA 1O99A 1ZEFA 1N2LA 4FDIA 4KM4A 4N7TA 4UPIA 4MIVA 3T01A 1ALKA 3UO0A 2W8DA 2W5SA 5EGEA 1N2KA 3NKOA 2D1GA 3WAVA 3DYCA 3BDGA 1ANJA 3T02A 2GA3A 3T00A 3WAWA 3NKRA 5TJ3A 2VQRA 2W5RA 2X98A 2IFYA 4ZGAA 5L0BA 2W5QA 2GSOA 4ZG6A 3IGYB 3CMRA 2W5VA 4MHXA 5GRRA 3NKPA 5DLWA 3IDDA 1ALHA 1ALIA 1FSUA 3WAYA 5L0KA 4ZG9A 3UN2A 3M8WA 1EJJA 1KHNA 4YR1A 1ELYA 2QZUA 4FDJA 1KH4A 1Y7AA 4CYSA 1HJKA 4LRCA 3NKQA 4GTXA 4KAYA 3WAXA 3A52A 3TWZA 4CXUA 2ANHA 5LRMA 5LIAA 1AJBA 4ZG7A 5KXAA 4LR9A 4UORA 3TG0A 3ED4A 1EW2A 4LQYA 1Y6VA 4LRDA 4LRFA 4CXSA 4LRBA 4LREA 1AJCA 1AUKA 4UPKA 5L0EA 1EW9A 4GTYA
chains in the Genus database with same CATH topology
1AJAA 2G9YA 4GTZA 2XR9A 3MK1A 4MY4A 2W5XA 4B56A 5C66A 1ZEBA 3SZYA 4LR8A 1O98A 2ZKTA 1KHLA 5GOVA 1AJDA 3NKMA 4CXKA 1E2SP 4KAVA 4KJDA 4UOOA 5DLVA 4GTWA 1HDHA 1KHJA 5LQQA 1EI6A 1ED9A 1URAA 1P49A 3BDHA 1SHQA 2W5WA 3UNYA 1HQAA 2RH6A 1KH7A 1ED8A 1EW8A 1ZEDA 3MK2A 1ELZA 4UPHA 1K7HA 3BDFA 1EQJA 3DPCA 1SHNA 3SZZA 1E3CP 1ANIA 5HRTA 2XRGA 3B5QA 4LR2A 5EGHA 4NWJA 4UOPA 5INHA 2GLQA 3OT9A 5LRNA 3UN5A 2GSUA 1ALJA 1E1ZP 1KH5A 3E2DA 3NKNA 3IGZB 3LXQA 2W5TA 3M8YA 4LR7A 5DLTA 3WBHA 3KD8A 3MK0A 5AJ9A 4NWXA 2IUCB 2W8SA 4LRAA 4QAXA 4UPLA 3Q3QA 1KHKA 5IJQA 1URBA 5K4PA 3TX0A 5IJSA 3M7VA 3M8ZA 1E33P 1B8JA 3BDGB 3UN3A 1KH9A 4TN0A 4KJGA 2IUCA 2GSNA 4CYRA 3NVLA 1ELXA 1O99A 1ZEFA 1N2LA 4FDIA 4KM4A 4N7TA 4UPIA 4MIVA 3T01A 1ALKA 3UO0A 2W8DA 2W5SA 5EGEA 1N2KA 3NKOA 2D1GA 3WAVA 3DYCA 3BDGA 1ANJA 3T02A 2GA3A 3T00A 3WAWA 3NKRA 5TJ3A 2VQRA 2W5RA 2X98A 2IFYA 4ZGAA 5L0BA 2W5QA 2GSOA 4ZG6A 3IGYB 3CMRA 2W5VA 4MHXA 5GRRA 3NKPA 5DLWA 3IDDA 1ALHA 1ALIA 1FSUA 3WAYA 5L0KA 4ZG9A 3UN2A 3M8WA 1EJJA 1KHNA 4YR1A 1ELYA 2QZUA 4FDJA 1KH4A 1Y7AA 4CYSA 1HJKA 4LRCA 3NKQA 4GTXA 4KAYA 3WAXA 3A52A 3TWZA 4CXUA 2ANHA 5LRMA 5LIAA 1AJBA 4ZG7A 5KXAA 4LR9A 4UORA 3TG0A 3ED4A 1EW2A 4LQYA 1Y6VA 4LRDA 4LRFA 4CXSA 4LRBA 4LREA 1AJCA 1AUKA 4UPKA 5L0EA 1EW9A 4GTYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AJA A;  2G9Y A;  4GTZ A;  2XR9 A;  3MK1 A;  4MY4 A;  2W5X A;  4B56 A;  5C66 A;  1ZEB A;  3SZY A;  4LR8 A;  1O98 A;  2ZKT A;  1KHL A;  5GOV A;  1AJD A;  3NKM A;  4CXK A;  1E2S P;  4KAV A;  4KJD A;  4UOO A;  5DLV A;  4GTW A;  1HDH A;  1KHJ A;  5LQQ A;  1EI6 A;  1ED9 A;  1URA A;  1P49 A;  3BDH A;  1SHQ A;  2W5W A;  3UNY A;  1HQA A;  2RH6 A;  1KH7 A;  1ED8 A;  1EW8 A;  1ZED A;  3MK2 A;  1ELZ A;  4UPH A;  1K7H A;  3BDF A;  1EQJ A;  3DPC A;  1SHN A;  3SZZ A;  1E3C P;  1ANI A;  5HRT A;  2XRG A;  3B5Q A;  4LR2 A;  5EGH A;  4NWJ A;  4UOP A;  5INH A;  2GLQ A;  3OT9 A;  5LRN A;  3UN5 A;  2GSU A;  1ALJ A;  1E1Z P;  1KH5 A;  3E2D A;  3NKN A;  3IGZ B;  3LXQ A;  2W5T A;  3M8Y A;  4LR7 A;  5DLT A;  3WBH A;  3KD8 A;  3MK0 A;  5AJ9 A;  4NWX A;  2IUC B;  2W8S A;  4LRA A;  4QAX A;  4UPL A;  3Q3Q A;  1KHK A;  5IJQ A;  1URB A;  5K4P A;  3TX0 A;  5IJS A;  3M7V A;  3M8Z A;  1E33 P;  1B8J A;  3BDG B;  3UN3 A;  1KH9 A;  4TN0 A;  4KJG A;  2IUC A;  2GSN A;  4CYR A;  3NVL A;  1ELX A;  1O99 A;  1ZEF A;  1N2L A;  4FDI A;  4KM4 A;  4N7T A;  4UPI A;  4MIV A;  3T01 A;  1ALK A;  3UO0 A;  2W8D A;  2W5S A;  5EGE A;  1N2K A;  3NKO A;  2D1G A;  3WAV A;  3DYC A;  3BDG A;  1ANJ A;  3T02 A;  2GA3 A;  3T00 A;  3WAW A;  3NKR A;  5TJ3 A;  2VQR A;  2W5R A;  2X98 A;  2IFY A;  4ZGA A;  5L0B A;  2W5Q A;  2GSO A;  4ZG6 A;  3IGY B;  3CMR A;  2W5V A;  4MHX A;  5GRR A;  3NKP A;  5DLW A;  3IDD A;  1ALH A;  1ALI A;  1FSU A;  3WAY A;  5L0K A;  4ZG9 A;  3UN2 A;  3M8W A;  1EJJ A;  1KHN A;  4YR1 A;  1ELY A;  2QZU A;  4FDJ A;  1KH4 A;  1Y7A A;  4CYS A;  1HJK A;  4LRC A;  3NKQ A;  4GTX A;  4KAY A;  3WAX A;  3A52 A;  3TWZ A;  4CXU A;  2ANH A;  5LRM A;  5LIA A;  1AJB A;  4ZG7 A;  5KXA A;  4LR9 A;  4UOR A;  3TG0 A;  3ED4 A;  1EW2 A;  4LQY A;  1Y6V A;  4LRD A;  4LRF A;  4CXS A;  4LRB A;  4LRE A;  1AJC A;  1AUK A;  4UPK A;  5L0E A;  1EW9 A;  4GTY A; 
#chains in the Genus database with same CATH topology
 1AJA A;  2G9Y A;  4GTZ A;  2XR9 A;  3MK1 A;  4MY4 A;  2W5X A;  4B56 A;  5C66 A;  1ZEB A;  3SZY A;  4LR8 A;  1O98 A;  2ZKT A;  1KHL A;  5GOV A;  1AJD A;  3NKM A;  4CXK A;  1E2S P;  4KAV A;  4KJD A;  4UOO A;  5DLV A;  4GTW A;  1HDH A;  1KHJ A;  5LQQ A;  1EI6 A;  1ED9 A;  1URA A;  1P49 A;  3BDH A;  1SHQ A;  2W5W A;  3UNY A;  1HQA A;  2RH6 A;  1KH7 A;  1ED8 A;  1EW8 A;  1ZED A;  3MK2 A;  1ELZ A;  4UPH A;  1K7H A;  3BDF A;  1EQJ A;  3DPC A;  1SHN A;  3SZZ A;  1E3C P;  1ANI A;  5HRT A;  2XRG A;  3B5Q A;  4LR2 A;  5EGH A;  4NWJ A;  4UOP A;  5INH A;  2GLQ A;  3OT9 A;  5LRN A;  3UN5 A;  2GSU A;  1ALJ A;  1E1Z P;  1KH5 A;  3E2D A;  3NKN A;  3IGZ B;  3LXQ A;  2W5T A;  3M8Y A;  4LR7 A;  5DLT A;  3WBH A;  3KD8 A;  3MK0 A;  5AJ9 A;  4NWX A;  2IUC B;  2W8S A;  4LRA A;  4QAX A;  4UPL A;  3Q3Q A;  1KHK A;  5IJQ A;  1URB A;  5K4P A;  3TX0 A;  5IJS A;  3M7V A;  3M8Z A;  1E33 P;  1B8J A;  3BDG B;  3UN3 A;  1KH9 A;  4TN0 A;  4KJG A;  2IUC A;  2GSN A;  4CYR A;  3NVL A;  1ELX A;  1O99 A;  1ZEF A;  1N2L A;  4FDI A;  4KM4 A;  4N7T A;  4UPI A;  4MIV A;  3T01 A;  1ALK A;  3UO0 A;  2W8D A;  2W5S A;  5EGE A;  1N2K A;  3NKO A;  2D1G A;  3WAV A;  3DYC A;  3BDG A;  1ANJ A;  3T02 A;  2GA3 A;  3T00 A;  3WAW A;  3NKR A;  5TJ3 A;  2VQR A;  2W5R A;  2X98 A;  2IFY A;  4ZGA A;  5L0B A;  2W5Q A;  2GSO A;  4ZG6 A;  3IGY B;  3CMR A;  2W5V A;  4MHX A;  5GRR A;  3NKP A;  5DLW A;  3IDD A;  1ALH A;  1ALI A;  1FSU A;  3WAY A;  5L0K A;  4ZG9 A;  3UN2 A;  3M8W A;  1EJJ A;  1KHN A;  4YR1 A;  1ELY A;  2QZU A;  4FDJ A;  1KH4 A;  1Y7A A;  4CYS A;  1HJK A;  4LRC A;  3NKQ A;  4GTX A;  4KAY A;  3WAX A;  3A52 A;  3TWZ A;  4CXU A;  2ANH A;  5LRM A;  5LIA A;  1AJB A;  4ZG7 A;  5KXA A;  4LR9 A;  4UOR A;  3TG0 A;  3ED4 A;  1EW2 A;  4LQY A;  1Y6V A;  4LRD A;  4LRF A;  4CXS A;  4LRB A;  4LRE A;  1AJC A;  1AUK A;  4UPK A;  5L0E A;  1EW9 A;  4GTY A; 
#chains in the Genus database with same CATH homology
 1AJA A;  2G9Y A;  4GTZ A;  2XR9 A;  3MK1 A;  4MY4 A;  2W5X A;  4B56 A;  5C66 A;  1ZEB A;  3SZY A;  4LR8 A;  1O98 A;  2ZKT A;  1KHL A;  5GOV A;  1AJD A;  3NKM A;  4CXK A;  1E2S P;  4KAV A;  4KJD A;  4UOO A;  5DLV A;  4GTW A;  1HDH A;  1KHJ A;  5LQQ A;  1EI6 A;  1ED9 A;  1URA A;  1P49 A;  3BDH A;  1SHQ A;  2W5W A;  3UNY A;  1HQA A;  2RH6 A;  1KH7 A;  1ED8 A;  1EW8 A;  1ZED A;  3MK2 A;  1ELZ A;  4UPH A;  1K7H A;  3BDF A;  1EQJ A;  3DPC A;  1SHN A;  3SZZ A;  1E3C P;  1ANI A;  5HRT A;  2XRG A;  3B5Q A;  4LR2 A;  5EGH A;  4NWJ A;  4UOP A;  5INH A;  2GLQ A;  3OT9 A;  5LRN A;  3UN5 A;  2GSU A;  1ALJ A;  1E1Z P;  1KH5 A;  3E2D A;  3NKN A;  3IGZ B;  3LXQ A;  2W5T A;  3M8Y A;  4LR7 A;  5DLT A;  3WBH A;  3KD8 A;  3MK0 A;  5AJ9 A;  4NWX A;  2IUC B;  2W8S A;  4LRA A;  4QAX A;  4UPL A;  3Q3Q A;  1KHK A;  5IJQ A;  1URB A;  5K4P A;  3TX0 A;  5IJS A;  3M7V A;  3M8Z A;  1E33 P;  1B8J A;  3BDG B;  3UN3 A;  1KH9 A;  4TN0 A;  4KJG A;  2IUC A;  2GSN A;  4CYR A;  3NVL A;  1ELX A;  1O99 A;  1ZEF A;  1N2L A;  4FDI A;  4KM4 A;  4N7T A;  4UPI A;  4MIV A;  3T01 A;  1ALK A;  3UO0 A;  2W8D A;  2W5S A;  5EGE A;  1N2K A;  3NKO A;  2D1G A;  3WAV A;  3DYC A;  3BDG A;  1ANJ A;  3T02 A;  2GA3 A;  3T00 A;  3WAW A;  3NKR A;  5TJ3 A;  2VQR A;  2W5R A;  2X98 A;  2IFY A;  4ZGA A;  5L0B A;  2W5Q A;  2GSO A;  4ZG6 A;  3IGY B;  3CMR A;  2W5V A;  4MHX A;  5GRR A;  3NKP A;  5DLW A;  3IDD A;  1ALH A;  1ALI A;  1FSU A;  3WAY A;  5L0K A;  4ZG9 A;  3UN2 A;  3M8W A;  1EJJ A;  1KHN A;  4YR1 A;  1ELY A;  2QZU A;  4FDJ A;  1KH4 A;  1Y7A A;  4CYS A;  1HJK A;  4LRC A;  3NKQ A;  4GTX A;  4KAY A;  3WAX A;  3A52 A;  3TWZ A;  4CXU A;  2ANH A;  5LRM A;  5LIA A;  1AJB A;  4ZG7 A;  5KXA A;  4LR9 A;  4UOR A;  3TG0 A;  3ED4 A;  1EW2 A;  4LQY A;  1Y6V A;  4LRD A;  4LRF A;  4CXS A;  4LRB A;  4LRE A;  1AJC A;  1AUK A;  4UPK A;  5L0E A;  1EW9 A;  4GTY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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