1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
4FDIA 4ZGAA 3BDGB 1HQAA 1EW9A 5K4PA 1KH9A 4LRBA 2IUCA 4KJDA 2W5VA 4LR8A 1URAA 2GLQA 5LIAA 1ANIA 4GTXA 1HJKA 3UN3A 4N7TA 2IUCB 2RH6A 1KH5A 3NVLA 5TJ3A 4KAYA 3SZZA 3NKOA 2ANHA 4LRAA 4KM4A 3E2DA 5IJSA 1ALJA 3IGYB 1ELZA 1KHLA 1E33P 1ED9A 1EW8A 5EGHA 4CYSA 3MK0A 1KHNA 2W5QA 3NKMA 1AJCA 4KAVA 5DLVA 1EJJA 3TG0A 3WAVA 1N2KA 4UOOA 1O98A 4CYRA 3WAWA 3T02A 1ELXA 1N2LA 3B5QA 5LRNA 4NWJA 5L0KA 1AJAA 4CXUA 5KXAA 3SZYA 4ZG6A 2GSUA 1E1ZP 4LR9A 1E3CP 3Q3QA 4KJGA 4UPKA 1ALHA 1ZEDA 3TWZA 5DLTA 5DLWA 3WAYA 5GOVA 4UPHA 3M8ZA 2W5RA 5EGEA 4UPLA 1KH7A 3NKQA 3DPCA 3ED4A 3BDFA 2XR9A 4CXKA 3DYCA 1ELYA 3UNYA 1EW2A 3KD8A 1Y7AA 4FDJA 2D1GA 3IGZB 4MIVA 1ZEFA 3NKPA 4LREA 3MK2A 4B56A 3NKNA 3M8YA 1AJBA 1E2SP 4LRDA 3OT9A 1B8JA 1KH4A 2W5SA 2W8SA 3NKRA 4LR7A 2W5WA 3M7VA 2IFYA 3CMRA 1SHQA 1SHNA 4UPIA 5GRRA 2GA3A 2W5TA 3UO0A 4ZG7A 4LRFA 4LRCA 5L0EA 4ZG9A 3M8WA 1ANJA 1O99A 3BDHA 4GTWA 5AJ9A 3WBHA 3WAXA 5INHA 4MHXA 2W8DA 1URBA 3T01A 3UN5A 4TN0A 5C66A 3UN2A 2ZKTA 4YR1A 2GSNA 4LR2A 1ED8A 5L0BA 3MK1A 4GTZA 4UORA 4NWXA 5LQQA 1FSUA 1EQJA 2QZUA 3T00A 1P49A 1KHJA 3IDDA 4GTYA 1AUKA 1Y6VA 3A52A 1AJDA 2W5XA 2XRGA 5LRMA 2VQRA 4CXSA 3TX0A 2G9YA 3LXQA 4MY4A 4UOPA 1ALIA 4QAXA 3BDGA 1HDHA 5HRTA 4LQYA 5IJQA 1KHKA 2X98A 1EI6A 1ZEBA 1ALKA 2GSOA 1K7HA
chains in the Genus database with same CATH superfamily
4FDIA 4ZGAA 3BDGB 1HQAA 1EW9A 5K4PA 1KH9A 4LRBA 2IUCA 4KJDA 2W5VA 4LR8A 1URAA 2GLQA 5LIAA 1ANIA 4GTXA 1HJKA 3UN3A 4N7TA 2IUCB 2RH6A 1KH5A 3NVLA 5TJ3A 4KAYA 3SZZA 3NKOA 2ANHA 4LRAA 4KM4A 3E2DA 5IJSA 1ALJA 3IGYB 1ELZA 1KHLA 1E33P 1ED9A 1EW8A 5EGHA 4CYSA 3MK0A 1KHNA 2W5QA 3NKMA 1AJCA 4KAVA 5DLVA 1EJJA 3TG0A 3WAVA 1N2KA 4UOOA 1O98A 4CYRA 3WAWA 3T02A 1ELXA 1N2LA 3B5QA 5LRNA 4NWJA 5L0KA 1AJAA 4CXUA 5KXAA 3SZYA 4ZG6A 2GSUA 1E1ZP 4LR9A 1E3CP 3Q3QA 4KJGA 4UPKA 1ALHA 1ZEDA 3TWZA 5DLTA 5DLWA 3WAYA 5GOVA 4UPHA 3M8ZA 2W5RA 5EGEA 4UPLA 1KH7A 3NKQA 3DPCA 3ED4A 3BDFA 2XR9A 4CXKA 3DYCA 1ELYA 3UNYA 1EW2A 3KD8A 1Y7AA 4FDJA 2D1GA 3IGZB 4MIVA 1ZEFA 3NKPA 4LREA 3MK2A 4B56A 3NKNA 3M8YA 1AJBA 1E2SP 4LRDA 3OT9A 1B8JA 1KH4A 2W5SA 2W8SA 3NKRA 4LR7A 2W5WA 3M7VA 2IFYA 3CMRA 1SHQA 1SHNA 4UPIA 5GRRA 2GA3A 2W5TA 3UO0A 4ZG7A 4LRFA 4LRCA 5L0EA 4ZG9A 3M8WA 1ANJA 1O99A 3BDHA 4GTWA 5AJ9A 3WBHA 3WAXA 5INHA 4MHXA 2W8DA 1URBA 3T01A 3UN5A 4TN0A 5C66A 3UN2A 2ZKTA 4YR1A 2GSNA 4LR2A 1ED8A 5L0BA 3MK1A 4GTZA 4UORA 4NWXA 5LQQA 1FSUA 1EQJA 2QZUA 3T00A 1P49A 1KHJA 3IDDA 4GTYA 1AUKA 1Y6VA 3A52A 1AJDA 2W5XA 2XRGA 5LRMA 2VQRA 4CXSA 3TX0A 2G9YA 3LXQA 4MY4A 4UOPA 1ALIA 4QAXA 3BDGA 1HDHA 5HRTA 4LQYA 5IJQA 1KHKA 2X98A 1EI6A 1ZEBA 1ALKA 2GSOA 1K7HA
chains in the Genus database with same CATH topology
4FDIA 4ZGAA 3BDGB 1HQAA 1EW9A 5K4PA 1KH9A 4LRBA 2IUCA 4KJDA 2W5VA 4LR8A 1URAA 2GLQA 5LIAA 1ANIA 4GTXA 1HJKA 3UN3A 4N7TA 2IUCB 2RH6A 1KH5A 3NVLA 5TJ3A 4KAYA 3SZZA 3NKOA 2ANHA 4LRAA 4KM4A 3E2DA 5IJSA 1ALJA 3IGYB 1ELZA 1KHLA 1E33P 1ED9A 1EW8A 5EGHA 4CYSA 3MK0A 1KHNA 2W5QA 3NKMA 1AJCA 4KAVA 5DLVA 1EJJA 3TG0A 3WAVA 1N2KA 4UOOA 1O98A 4CYRA 3WAWA 3T02A 1ELXA 1N2LA 3B5QA 5LRNA 4NWJA 5L0KA 1AJAA 4CXUA 5KXAA 3SZYA 4ZG6A 2GSUA 1E1ZP 4LR9A 1E3CP 3Q3QA 4KJGA 4UPKA 1ALHA 1ZEDA 3TWZA 5DLTA 5DLWA 3WAYA 5GOVA 4UPHA 3M8ZA 2W5RA 5EGEA 4UPLA 1KH7A 3NKQA 3DPCA 3ED4A 3BDFA 2XR9A 4CXKA 3DYCA 1ELYA 3UNYA 1EW2A 3KD8A 1Y7AA 4FDJA 2D1GA 3IGZB 4MIVA 1ZEFA 3NKPA 4LREA 3MK2A 4B56A 3NKNA 3M8YA 1AJBA 1E2SP 4LRDA 3OT9A 1B8JA 1KH4A 2W5SA 2W8SA 3NKRA 4LR7A 2W5WA 3M7VA 2IFYA 3CMRA 1SHQA 1SHNA 4UPIA 5GRRA 2GA3A 2W5TA 3UO0A 4ZG7A 4LRFA 4LRCA 5L0EA 4ZG9A 3M8WA 1ANJA 1O99A 3BDHA 4GTWA 5AJ9A 3WBHA 3WAXA 5INHA 4MHXA 2W8DA 1URBA 3T01A 3UN5A 4TN0A 5C66A 3UN2A 2ZKTA 4YR1A 2GSNA 4LR2A 1ED8A 5L0BA 3MK1A 4GTZA 4UORA 4NWXA 5LQQA 1FSUA 1EQJA 2QZUA 3T00A 1P49A 1KHJA 3IDDA 4GTYA 1AUKA 1Y6VA 3A52A 1AJDA 2W5XA 2XRGA 5LRMA 2VQRA 4CXSA 3TX0A 2G9YA 3LXQA 4MY4A 4UOPA 1ALIA 4QAXA 3BDGA 1HDHA 5HRTA 4LQYA 5IJQA 1KHKA 2X98A 1EI6A 1ZEBA 1ALKA 2GSOA 1K7HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FDI A;  4ZGA A;  3BDG B;  1HQA A;  1EW9 A;  5K4P A;  1KH9 A;  4LRB A;  2IUC A;  4KJD A;  2W5V A;  4LR8 A;  1URA A;  2GLQ A;  5LIA A;  1ANI A;  4GTX A;  1HJK A;  3UN3 A;  4N7T A;  2IUC B;  2RH6 A;  1KH5 A;  3NVL A;  5TJ3 A;  4KAY A;  3SZZ A;  3NKO A;  2ANH A;  4LRA A;  4KM4 A;  3E2D A;  5IJS A;  1ALJ A;  3IGY B;  1ELZ A;  1KHL A;  1E33 P;  1ED9 A;  1EW8 A;  5EGH A;  4CYS A;  3MK0 A;  1KHN A;  2W5Q A;  3NKM A;  1AJC A;  4KAV A;  5DLV A;  1EJJ A;  3TG0 A;  3WAV A;  1N2K A;  4UOO A;  1O98 A;  4CYR A;  3WAW A;  3T02 A;  1ELX A;  1N2L A;  3B5Q A;  5LRN A;  4NWJ A;  5L0K A;  1AJA A;  4CXU A;  5KXA A;  3SZY A;  4ZG6 A;  2GSU A;  1E1Z P;  4LR9 A;  1E3C P;  3Q3Q A;  4KJG A;  4UPK A;  1ALH A;  1ZED A;  3TWZ A;  5DLT A;  5DLW A;  3WAY A;  5GOV A;  4UPH A;  3M8Z A;  2W5R A;  5EGE A;  4UPL A;  1KH7 A;  3NKQ A;  3DPC A;  3ED4 A;  3BDF A;  2XR9 A;  4CXK A;  3DYC A;  1ELY A;  3UNY A;  1EW2 A;  3KD8 A;  1Y7A A;  4FDJ A;  2D1G A;  3IGZ B;  4MIV A;  1ZEF A;  3NKP A;  4LRE A;  3MK2 A;  4B56 A;  3NKN A;  3M8Y A;  1AJB A;  1E2S P;  4LRD A;  3OT9 A;  1B8J A;  1KH4 A;  2W5S A;  2W8S A;  3NKR A;  4LR7 A;  2W5W A;  3M7V A;  2IFY A;  3CMR A;  1SHQ A;  1SHN A;  4UPI A;  5GRR A;  2GA3 A;  2W5T A;  3UO0 A;  4ZG7 A;  4LRF A;  4LRC A;  5L0E A;  4ZG9 A;  3M8W A;  1ANJ A;  1O99 A;  3BDH A;  4GTW A;  5AJ9 A;  3WBH A;  3WAX A;  5INH A;  4MHX A;  2W8D A;  1URB A;  3T01 A;  3UN5 A;  4TN0 A;  5C66 A;  3UN2 A;  2ZKT A;  4YR1 A;  2GSN A;  4LR2 A;  1ED8 A;  5L0B A;  3MK1 A;  4GTZ A;  4UOR A;  4NWX A;  5LQQ A;  1FSU A;  1EQJ A;  2QZU A;  3T00 A;  1P49 A;  1KHJ A;  3IDD A;  4GTY A;  1AUK A;  1Y6V A;  3A52 A;  1AJD A;  2W5X A;  2XRG A;  5LRM A;  2VQR A;  4CXS A;  3TX0 A;  2G9Y A;  3LXQ A;  4MY4 A;  4UOP A;  1ALI A;  4QAX A;  3BDG A;  1HDH A;  5HRT A;  4LQY A;  5IJQ A;  1KHK A;  2X98 A;  1EI6 A;  1ZEB A;  1ALK A;  2GSO A;  1K7H A; 
#chains in the Genus database with same CATH topology
 4FDI A;  4ZGA A;  3BDG B;  1HQA A;  1EW9 A;  5K4P A;  1KH9 A;  4LRB A;  2IUC A;  4KJD A;  2W5V A;  4LR8 A;  1URA A;  2GLQ A;  5LIA A;  1ANI A;  4GTX A;  1HJK A;  3UN3 A;  4N7T A;  2IUC B;  2RH6 A;  1KH5 A;  3NVL A;  5TJ3 A;  4KAY A;  3SZZ A;  3NKO A;  2ANH A;  4LRA A;  4KM4 A;  3E2D A;  5IJS A;  1ALJ A;  3IGY B;  1ELZ A;  1KHL A;  1E33 P;  1ED9 A;  1EW8 A;  5EGH A;  4CYS A;  3MK0 A;  1KHN A;  2W5Q A;  3NKM A;  1AJC A;  4KAV A;  5DLV A;  1EJJ A;  3TG0 A;  3WAV A;  1N2K A;  4UOO A;  1O98 A;  4CYR A;  3WAW A;  3T02 A;  1ELX A;  1N2L A;  3B5Q A;  5LRN A;  4NWJ A;  5L0K A;  1AJA A;  4CXU A;  5KXA A;  3SZY A;  4ZG6 A;  2GSU A;  1E1Z P;  4LR9 A;  1E3C P;  3Q3Q A;  4KJG A;  4UPK A;  1ALH A;  1ZED A;  3TWZ A;  5DLT A;  5DLW A;  3WAY A;  5GOV A;  4UPH A;  3M8Z A;  2W5R A;  5EGE A;  4UPL A;  1KH7 A;  3NKQ A;  3DPC A;  3ED4 A;  3BDF A;  2XR9 A;  4CXK A;  3DYC A;  1ELY A;  3UNY A;  1EW2 A;  3KD8 A;  1Y7A A;  4FDJ A;  2D1G A;  3IGZ B;  4MIV A;  1ZEF A;  3NKP A;  4LRE A;  3MK2 A;  4B56 A;  3NKN A;  3M8Y A;  1AJB A;  1E2S P;  4LRD A;  3OT9 A;  1B8J A;  1KH4 A;  2W5S A;  2W8S A;  3NKR A;  4LR7 A;  2W5W A;  3M7V A;  2IFY A;  3CMR A;  1SHQ A;  1SHN A;  4UPI A;  5GRR A;  2GA3 A;  2W5T A;  3UO0 A;  4ZG7 A;  4LRF A;  4LRC A;  5L0E A;  4ZG9 A;  3M8W A;  1ANJ A;  1O99 A;  3BDH A;  4GTW A;  5AJ9 A;  3WBH A;  3WAX A;  5INH A;  4MHX A;  2W8D A;  1URB A;  3T01 A;  3UN5 A;  4TN0 A;  5C66 A;  3UN2 A;  2ZKT A;  4YR1 A;  2GSN A;  4LR2 A;  1ED8 A;  5L0B A;  3MK1 A;  4GTZ A;  4UOR A;  4NWX A;  5LQQ A;  1FSU A;  1EQJ A;  2QZU A;  3T00 A;  1P49 A;  1KHJ A;  3IDD A;  4GTY A;  1AUK A;  1Y6V A;  3A52 A;  1AJD A;  2W5X A;  2XRG A;  5LRM A;  2VQR A;  4CXS A;  3TX0 A;  2G9Y A;  3LXQ A;  4MY4 A;  4UOP A;  1ALI A;  4QAX A;  3BDG A;  1HDH A;  5HRT A;  4LQY A;  5IJQ A;  1KHK A;  2X98 A;  1EI6 A;  1ZEB A;  1ALK A;  2GSO A;  1K7H A; 
#chains in the Genus database with same CATH homology
 4FDI A;  4ZGA A;  3BDG B;  1HQA A;  1EW9 A;  5K4P A;  1KH9 A;  4LRB A;  2IUC A;  4KJD A;  2W5V A;  4LR8 A;  1URA A;  2GLQ A;  5LIA A;  1ANI A;  4GTX A;  1HJK A;  3UN3 A;  4N7T A;  2IUC B;  2RH6 A;  1KH5 A;  3NVL A;  5TJ3 A;  4KAY A;  3SZZ A;  3NKO A;  2ANH A;  4LRA A;  4KM4 A;  3E2D A;  5IJS A;  1ALJ A;  3IGY B;  1ELZ A;  1KHL A;  1E33 P;  1ED9 A;  1EW8 A;  5EGH A;  4CYS A;  3MK0 A;  1KHN A;  2W5Q A;  3NKM A;  1AJC A;  4KAV A;  5DLV A;  1EJJ A;  3TG0 A;  3WAV A;  1N2K A;  4UOO A;  1O98 A;  4CYR A;  3WAW A;  3T02 A;  1ELX A;  1N2L A;  3B5Q A;  5LRN A;  4NWJ A;  5L0K A;  1AJA A;  4CXU A;  5KXA A;  3SZY A;  4ZG6 A;  2GSU A;  1E1Z P;  4LR9 A;  1E3C P;  3Q3Q A;  4KJG A;  4UPK A;  1ALH A;  1ZED A;  3TWZ A;  5DLT A;  5DLW A;  3WAY A;  5GOV A;  4UPH A;  3M8Z A;  2W5R A;  5EGE A;  4UPL A;  1KH7 A;  3NKQ A;  3DPC A;  3ED4 A;  3BDF A;  2XR9 A;  4CXK A;  3DYC A;  1ELY A;  3UNY A;  1EW2 A;  3KD8 A;  1Y7A A;  4FDJ A;  2D1G A;  3IGZ B;  4MIV A;  1ZEF A;  3NKP A;  4LRE A;  3MK2 A;  4B56 A;  3NKN A;  3M8Y A;  1AJB A;  1E2S P;  4LRD A;  3OT9 A;  1B8J A;  1KH4 A;  2W5S A;  2W8S A;  3NKR A;  4LR7 A;  2W5W A;  3M7V A;  2IFY A;  3CMR A;  1SHQ A;  1SHN A;  4UPI A;  5GRR A;  2GA3 A;  2W5T A;  3UO0 A;  4ZG7 A;  4LRF A;  4LRC A;  5L0E A;  4ZG9 A;  3M8W A;  1ANJ A;  1O99 A;  3BDH A;  4GTW A;  5AJ9 A;  3WBH A;  3WAX A;  5INH A;  4MHX A;  2W8D A;  1URB A;  3T01 A;  3UN5 A;  4TN0 A;  5C66 A;  3UN2 A;  2ZKT A;  4YR1 A;  2GSN A;  4LR2 A;  1ED8 A;  5L0B A;  3MK1 A;  4GTZ A;  4UOR A;  4NWX A;  5LQQ A;  1FSU A;  1EQJ A;  2QZU A;  3T00 A;  1P49 A;  1KHJ A;  3IDD A;  4GTY A;  1AUK A;  1Y6V A;  3A52 A;  1AJD A;  2W5X A;  2XRG A;  5LRM A;  2VQR A;  4CXS A;  3TX0 A;  2G9Y A;  3LXQ A;  4MY4 A;  4UOP A;  1ALI A;  4QAX A;  3BDG A;  1HDH A;  5HRT A;  4LQY A;  5IJQ A;  1KHK A;  2X98 A;  1EI6 A;  1ZEB A;  1ALK A;  2GSO A;  1K7H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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