1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
4KAYA 4CYSA 1KHNA 2W5SA 3NKMA 1ANIA 3UN2A 4FDJA 4NWJA 4ZG6A 1ELZA 1O98A 3NKPA 4CXSA 3IGZB 3DYCA 4FDIA 3MK2A 3BDGA 2IUCA 1ELXA 1EW2A 3WAYA 1KHKA 4UPKA 2W5XA 1EQJA 3T00A 2XRGA 5GRRA 1P49A 3T02A 1KH7A 3M8YA 4GTYA 1E33P 3BDGB 4LR8A 4LRFA 4UPIA 1KH9A 4ZGAA 1ZEDA 3TX0A 3MK0A 3WBHA 1AJCA 3NKRA 1AJDA 2RH6A 4ZG9A 2D1GA 5KXAA 4NWXA 3E2DA 3UO0A 3B5QA 1E1ZP 1E3CP 4LRDA 3DPCA 1HDHA 4LR9A 5DLTA 1ZEFA 3BDFA 4UOPA 4CYRA 4CXKA 1AUKA 2W5VA 5IJSA 2ZKTA 3BDHA 3NKQA 3UNYA 3CMRA 4KJDA 4B56A 4N7TA 3M8ZA 1HJKA 4LQYA 5IJQA 1KHJA 2QZUA 1AJBA 2X98A 4MHXA 5LIAA 1O99A 3TWZA 1E2SP 5INHA 2ANHA 2W5WA 4KJGA 3SZZA 3NKNA 1KH5A 2W8DA 2IUCB 3IGYB 3NVLA 4LR7A 1B8JA 1EW8A 2W5TA 2GLQA 3LXQA 3WAWA 5L0KA 4UORA 4CXUA 5C66A 2VQRA 1ALKA 4QAXA 1KH4A 1ED9A 3OT9A 3TG0A 5EGHA 5L0EA 4MIVA 1EW9A 4MY4A 4GTWA 1ELYA 5L0BA 3Q3QA 3UN5A 1ANJA 4YR1A 1SHQA 4TN0A 3SZYA 3WAVA 1KHLA 4UOOA 4LRBA 3KD8A 2W8SA 3M8WA 4KAVA 2XR9A 5TJ3A 3WAXA 5HRTA 1EI6A 1ZEBA 5AJ9A 1SHNA 3T01A 4GTZA 1FSUA 3M7VA 3IDDA 4LRCA 2GA3A 5K4PA 2W5RA 1HQAA 1K7HA 4UPHA 4LREA 1URAA 1N2LA 5DLWA 4KM4A 2IFYA 1EJJA 1Y6VA 3NKOA 3ED4A 4UPLA 5GOVA 5DLVA 1Y7AA 1ALIA 1ED8A 4ZG7A 2GSUA 1URBA 3A52A 5LQQA 1AJAA 2GSNA 3MK1A 4LR2A 4LRAA 2G9YA 2W5QA 5LRNA 1ALHA 1N2KA 5LRMA 3UN3A 5EGEA 4GTXA 1ALJA 2GSOA
chains in the Genus database with same CATH superfamily
4KAYA 4CYSA 1KHNA 2W5SA 3NKMA 1ANIA 3UN2A 4FDJA 4NWJA 4ZG6A 1ELZA 1O98A 3NKPA 4CXSA 3IGZB 3DYCA 4FDIA 3MK2A 3BDGA 2IUCA 1ELXA 1EW2A 3WAYA 1KHKA 4UPKA 2W5XA 1EQJA 3T00A 2XRGA 5GRRA 1P49A 3T02A 1KH7A 3M8YA 4GTYA 1E33P 3BDGB 4LR8A 4LRFA 4UPIA 1KH9A 4ZGAA 1ZEDA 3TX0A 3MK0A 3WBHA 1AJCA 3NKRA 1AJDA 2RH6A 4ZG9A 2D1GA 5KXAA 4NWXA 3E2DA 3UO0A 3B5QA 1E1ZP 1E3CP 4LRDA 3DPCA 1HDHA 4LR9A 5DLTA 1ZEFA 3BDFA 4UOPA 4CYRA 4CXKA 1AUKA 2W5VA 5IJSA 2ZKTA 3BDHA 3NKQA 3UNYA 3CMRA 4KJDA 4B56A 4N7TA 3M8ZA 1HJKA 4LQYA 5IJQA 1KHJA 2QZUA 1AJBA 2X98A 4MHXA 5LIAA 1O99A 3TWZA 1E2SP 5INHA 2ANHA 2W5WA 4KJGA 3SZZA 3NKNA 1KH5A 2W8DA 2IUCB 3IGYB 3NVLA 4LR7A 1B8JA 1EW8A 2W5TA 2GLQA 3LXQA 3WAWA 5L0KA 4UORA 4CXUA 5C66A 2VQRA 1ALKA 4QAXA 1KH4A 1ED9A 3OT9A 3TG0A 5EGHA 5L0EA 4MIVA 1EW9A 4MY4A 4GTWA 1ELYA 5L0BA 3Q3QA 3UN5A 1ANJA 4YR1A 1SHQA 4TN0A 3SZYA 3WAVA 1KHLA 4UOOA 4LRBA 3KD8A 2W8SA 3M8WA 4KAVA 2XR9A 5TJ3A 3WAXA 5HRTA 1EI6A 1ZEBA 5AJ9A 1SHNA 3T01A 4GTZA 1FSUA 3M7VA 3IDDA 4LRCA 2GA3A 5K4PA 2W5RA 1HQAA 1K7HA 4UPHA 4LREA 1URAA 1N2LA 5DLWA 4KM4A 2IFYA 1EJJA 1Y6VA 3NKOA 3ED4A 4UPLA 5GOVA 5DLVA 1Y7AA 1ALIA 1ED8A 4ZG7A 2GSUA 1URBA 3A52A 5LQQA 1AJAA 2GSNA 3MK1A 4LR2A 4LRAA 2G9YA 2W5QA 5LRNA 1ALHA 1N2KA 5LRMA 3UN3A 5EGEA 4GTXA 1ALJA 2GSOA
chains in the Genus database with same CATH topology
4KAYA 4CYSA 1KHNA 2W5SA 3NKMA 1ANIA 3UN2A 4FDJA 4NWJA 4ZG6A 1ELZA 1O98A 3NKPA 4CXSA 3IGZB 3DYCA 4FDIA 3MK2A 3BDGA 2IUCA 1ELXA 1EW2A 3WAYA 1KHKA 4UPKA 2W5XA 1EQJA 3T00A 2XRGA 5GRRA 1P49A 3T02A 1KH7A 3M8YA 4GTYA 1E33P 3BDGB 4LR8A 4LRFA 4UPIA 1KH9A 4ZGAA 1ZEDA 3TX0A 3MK0A 3WBHA 1AJCA 3NKRA 1AJDA 2RH6A 4ZG9A 2D1GA 5KXAA 4NWXA 3E2DA 3UO0A 3B5QA 1E1ZP 1E3CP 4LRDA 3DPCA 1HDHA 4LR9A 5DLTA 1ZEFA 3BDFA 4UOPA 4CYRA 4CXKA 1AUKA 2W5VA 5IJSA 2ZKTA 3BDHA 3NKQA 3UNYA 3CMRA 4KJDA 4B56A 4N7TA 3M8ZA 1HJKA 4LQYA 5IJQA 1KHJA 2QZUA 1AJBA 2X98A 4MHXA 5LIAA 1O99A 3TWZA 1E2SP 5INHA 2ANHA 2W5WA 4KJGA 3SZZA 3NKNA 1KH5A 2W8DA 2IUCB 3IGYB 3NVLA 4LR7A 1B8JA 1EW8A 2W5TA 2GLQA 3LXQA 3WAWA 5L0KA 4UORA 4CXUA 5C66A 2VQRA 1ALKA 4QAXA 1KH4A 1ED9A 3OT9A 3TG0A 5EGHA 5L0EA 4MIVA 1EW9A 4MY4A 4GTWA 1ELYA 5L0BA 3Q3QA 3UN5A 1ANJA 4YR1A 1SHQA 4TN0A 3SZYA 3WAVA 1KHLA 4UOOA 4LRBA 3KD8A 2W8SA 3M8WA 4KAVA 2XR9A 5TJ3A 3WAXA 5HRTA 1EI6A 1ZEBA 5AJ9A 1SHNA 3T01A 4GTZA 1FSUA 3M7VA 3IDDA 4LRCA 2GA3A 5K4PA 2W5RA 1HQAA 1K7HA 4UPHA 4LREA 1URAA 1N2LA 5DLWA 4KM4A 2IFYA 1EJJA 1Y6VA 3NKOA 3ED4A 4UPLA 5GOVA 5DLVA 1Y7AA 1ALIA 1ED8A 4ZG7A 2GSUA 1URBA 3A52A 5LQQA 1AJAA 2GSNA 3MK1A 4LR2A 4LRAA 2G9YA 2W5QA 5LRNA 1ALHA 1N2KA 5LRMA 3UN3A 5EGEA 4GTXA 1ALJA 2GSOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KAY A;  4CYS A;  1KHN A;  2W5S A;  3NKM A;  1ANI A;  3UN2 A;  4FDJ A;  4NWJ A;  4ZG6 A;  1ELZ A;  1O98 A;  3NKP A;  4CXS A;  3IGZ B;  3DYC A;  4FDI A;  3MK2 A;  3BDG A;  2IUC A;  1ELX A;  1EW2 A;  3WAY A;  1KHK A;  4UPK A;  2W5X A;  1EQJ A;  3T00 A;  2XRG A;  5GRR A;  1P49 A;  3T02 A;  1KH7 A;  3M8Y A;  4GTY A;  1E33 P;  3BDG B;  4LR8 A;  4LRF A;  4UPI A;  1KH9 A;  4ZGA A;  1ZED A;  3TX0 A;  3MK0 A;  3WBH A;  1AJC A;  3NKR A;  1AJD A;  2RH6 A;  4ZG9 A;  2D1G A;  5KXA A;  4NWX A;  3E2D A;  3UO0 A;  3B5Q A;  1E1Z P;  1E3C P;  4LRD A;  3DPC A;  1HDH A;  4LR9 A;  5DLT A;  1ZEF A;  3BDF A;  4UOP A;  4CYR A;  4CXK A;  1AUK A;  2W5V A;  5IJS A;  2ZKT A;  3BDH A;  3NKQ A;  3UNY A;  3CMR A;  4KJD A;  4B56 A;  4N7T A;  3M8Z A;  1HJK A;  4LQY A;  5IJQ A;  1KHJ A;  2QZU A;  1AJB A;  2X98 A;  4MHX A;  5LIA A;  1O99 A;  3TWZ A;  1E2S P;  5INH A;  2ANH A;  2W5W A;  4KJG A;  3SZZ A;  3NKN A;  1KH5 A;  2W8D A;  2IUC B;  3IGY B;  3NVL A;  4LR7 A;  1B8J A;  1EW8 A;  2W5T A;  2GLQ A;  3LXQ A;  3WAW A;  5L0K A;  4UOR A;  4CXU A;  5C66 A;  2VQR A;  1ALK A;  4QAX A;  1KH4 A;  1ED9 A;  3OT9 A;  3TG0 A;  5EGH A;  5L0E A;  4MIV A;  1EW9 A;  4MY4 A;  4GTW A;  1ELY A;  5L0B A;  3Q3Q A;  3UN5 A;  1ANJ A;  4YR1 A;  1SHQ A;  4TN0 A;  3SZY A;  3WAV A;  1KHL A;  4UOO A;  4LRB A;  3KD8 A;  2W8S A;  3M8W A;  4KAV A;  2XR9 A;  5TJ3 A;  3WAX A;  5HRT A;  1EI6 A;  1ZEB A;  5AJ9 A;  1SHN A;  3T01 A;  4GTZ A;  1FSU A;  3M7V A;  3IDD A;  4LRC A;  2GA3 A;  5K4P A;  2W5R A;  1HQA A;  1K7H A;  4UPH A;  4LRE A;  1URA A;  1N2L A;  5DLW A;  4KM4 A;  2IFY A;  1EJJ A;  1Y6V A;  3NKO A;  3ED4 A;  4UPL A;  5GOV A;  5DLV A;  1Y7A A;  1ALI A;  1ED8 A;  4ZG7 A;  2GSU A;  1URB A;  3A52 A;  5LQQ A;  1AJA A;  2GSN A;  3MK1 A;  4LR2 A;  4LRA A;  2G9Y A;  2W5Q A;  5LRN A;  1ALH A;  1N2K A;  5LRM A;  3UN3 A;  5EGE A;  4GTX A;  1ALJ A;  2GSO A; 
#chains in the Genus database with same CATH topology
 4KAY A;  4CYS A;  1KHN A;  2W5S A;  3NKM A;  1ANI A;  3UN2 A;  4FDJ A;  4NWJ A;  4ZG6 A;  1ELZ A;  1O98 A;  3NKP A;  4CXS A;  3IGZ B;  3DYC A;  4FDI A;  3MK2 A;  3BDG A;  2IUC A;  1ELX A;  1EW2 A;  3WAY A;  1KHK A;  4UPK A;  2W5X A;  1EQJ A;  3T00 A;  2XRG A;  5GRR A;  1P49 A;  3T02 A;  1KH7 A;  3M8Y A;  4GTY A;  1E33 P;  3BDG B;  4LR8 A;  4LRF A;  4UPI A;  1KH9 A;  4ZGA A;  1ZED A;  3TX0 A;  3MK0 A;  3WBH A;  1AJC A;  3NKR A;  1AJD A;  2RH6 A;  4ZG9 A;  2D1G A;  5KXA A;  4NWX A;  3E2D A;  3UO0 A;  3B5Q A;  1E1Z P;  1E3C P;  4LRD A;  3DPC A;  1HDH A;  4LR9 A;  5DLT A;  1ZEF A;  3BDF A;  4UOP A;  4CYR A;  4CXK A;  1AUK A;  2W5V A;  5IJS A;  2ZKT A;  3BDH A;  3NKQ A;  3UNY A;  3CMR A;  4KJD A;  4B56 A;  4N7T A;  3M8Z A;  1HJK A;  4LQY A;  5IJQ A;  1KHJ A;  2QZU A;  1AJB A;  2X98 A;  4MHX A;  5LIA A;  1O99 A;  3TWZ A;  1E2S P;  5INH A;  2ANH A;  2W5W A;  4KJG A;  3SZZ A;  3NKN A;  1KH5 A;  2W8D A;  2IUC B;  3IGY B;  3NVL A;  4LR7 A;  1B8J A;  1EW8 A;  2W5T A;  2GLQ A;  3LXQ A;  3WAW A;  5L0K A;  4UOR A;  4CXU A;  5C66 A;  2VQR A;  1ALK A;  4QAX A;  1KH4 A;  1ED9 A;  3OT9 A;  3TG0 A;  5EGH A;  5L0E A;  4MIV A;  1EW9 A;  4MY4 A;  4GTW A;  1ELY A;  5L0B A;  3Q3Q A;  3UN5 A;  1ANJ A;  4YR1 A;  1SHQ A;  4TN0 A;  3SZY A;  3WAV A;  1KHL A;  4UOO A;  4LRB A;  3KD8 A;  2W8S A;  3M8W A;  4KAV A;  2XR9 A;  5TJ3 A;  3WAX A;  5HRT A;  1EI6 A;  1ZEB A;  5AJ9 A;  1SHN A;  3T01 A;  4GTZ A;  1FSU A;  3M7V A;  3IDD A;  4LRC A;  2GA3 A;  5K4P A;  2W5R A;  1HQA A;  1K7H A;  4UPH A;  4LRE A;  1URA A;  1N2L A;  5DLW A;  4KM4 A;  2IFY A;  1EJJ A;  1Y6V A;  3NKO A;  3ED4 A;  4UPL A;  5GOV A;  5DLV A;  1Y7A A;  1ALI A;  1ED8 A;  4ZG7 A;  2GSU A;  1URB A;  3A52 A;  5LQQ A;  1AJA A;  2GSN A;  3MK1 A;  4LR2 A;  4LRA A;  2G9Y A;  2W5Q A;  5LRN A;  1ALH A;  1N2K A;  5LRM A;  3UN3 A;  5EGE A;  4GTX A;  1ALJ A;  2GSO A; 
#chains in the Genus database with same CATH homology
 4KAY A;  4CYS A;  1KHN A;  2W5S A;  3NKM A;  1ANI A;  3UN2 A;  4FDJ A;  4NWJ A;  4ZG6 A;  1ELZ A;  1O98 A;  3NKP A;  4CXS A;  3IGZ B;  3DYC A;  4FDI A;  3MK2 A;  3BDG A;  2IUC A;  1ELX A;  1EW2 A;  3WAY A;  1KHK A;  4UPK A;  2W5X A;  1EQJ A;  3T00 A;  2XRG A;  5GRR A;  1P49 A;  3T02 A;  1KH7 A;  3M8Y A;  4GTY A;  1E33 P;  3BDG B;  4LR8 A;  4LRF A;  4UPI A;  1KH9 A;  4ZGA A;  1ZED A;  3TX0 A;  3MK0 A;  3WBH A;  1AJC A;  3NKR A;  1AJD A;  2RH6 A;  4ZG9 A;  2D1G A;  5KXA A;  4NWX A;  3E2D A;  3UO0 A;  3B5Q A;  1E1Z P;  1E3C P;  4LRD A;  3DPC A;  1HDH A;  4LR9 A;  5DLT A;  1ZEF A;  3BDF A;  4UOP A;  4CYR A;  4CXK A;  1AUK A;  2W5V A;  5IJS A;  2ZKT A;  3BDH A;  3NKQ A;  3UNY A;  3CMR A;  4KJD A;  4B56 A;  4N7T A;  3M8Z A;  1HJK A;  4LQY A;  5IJQ A;  1KHJ A;  2QZU A;  1AJB A;  2X98 A;  4MHX A;  5LIA A;  1O99 A;  3TWZ A;  1E2S P;  5INH A;  2ANH A;  2W5W A;  4KJG A;  3SZZ A;  3NKN A;  1KH5 A;  2W8D A;  2IUC B;  3IGY B;  3NVL A;  4LR7 A;  1B8J A;  1EW8 A;  2W5T A;  2GLQ A;  3LXQ A;  3WAW A;  5L0K A;  4UOR A;  4CXU A;  5C66 A;  2VQR A;  1ALK A;  4QAX A;  1KH4 A;  1ED9 A;  3OT9 A;  3TG0 A;  5EGH A;  5L0E A;  4MIV A;  1EW9 A;  4MY4 A;  4GTW A;  1ELY A;  5L0B A;  3Q3Q A;  3UN5 A;  1ANJ A;  4YR1 A;  1SHQ A;  4TN0 A;  3SZY A;  3WAV A;  1KHL A;  4UOO A;  4LRB A;  3KD8 A;  2W8S A;  3M8W A;  4KAV A;  2XR9 A;  5TJ3 A;  3WAX A;  5HRT A;  1EI6 A;  1ZEB A;  5AJ9 A;  1SHN A;  3T01 A;  4GTZ A;  1FSU A;  3M7V A;  3IDD A;  4LRC A;  2GA3 A;  5K4P A;  2W5R A;  1HQA A;  1K7H A;  4UPH A;  4LRE A;  1URA A;  1N2L A;  5DLW A;  4KM4 A;  2IFY A;  1EJJ A;  1Y6V A;  3NKO A;  3ED4 A;  4UPL A;  5GOV A;  5DLV A;  1Y7A A;  1ALI A;  1ED8 A;  4ZG7 A;  2GSU A;  1URB A;  3A52 A;  5LQQ A;  1AJA A;  2GSN A;  3MK1 A;  4LR2 A;  4LRA A;  2G9Y A;  2W5Q A;  5LRN A;  1ALH A;  1N2K A;  5LRM A;  3UN3 A;  5EGE A;  4GTX A;  1ALJ A;  2GSO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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