1KH5A

E. coli alkaline phosphatase mutant (d330n) mimic of the transition states with aluminium fluoride
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 151
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh5A00
3M8WA 5LRMA 4CXKA 2W5SA 3DYCA 3KD8A 4FDIA 2W5RA 4YR1A 2IUCA 3M8YA 2W5QA 3ED4A 5AJ9A 5L0EA 3DPCA 3NVLA 3NKOA 3T00A 3A52A 3SZYA 5LQQA 3MK2A 1O98A 3NKNA 1Y6VA 3LXQA 2X98A 2W5TA 4NWXA 4UPHA 1ZEDA 3TX0A 1FSUA 4LREA 1KHJA 1EJJA 2W5VA 2XRGA 1ZEFA 5GRRA 3NKMA 2GSUA 1E2SP 1B8JA 3BDGA 1ALKA 1ALHA 3Q3QA 5GOVA 4GTWA 1N2LA 4ZGAA 1ALJA 3WAWA 4CYSA 1SHNA 3B5QA 4CXUA 1ANIA 4UORA 3UO0A 1ED8A 1E3CP 5C66A 5LRNA 4UPLA 1HJKA 3MK1A 5INHA 2ZKTA 1E33P 2GLQA 4B56A 3TWZA 2W8DA 4LRBA 2QZUA 4ZG7A 5KXAA 4UPKA 1K7HA 3T02A 4GTXA 1AJDA 2W5WA 3TG0A 1P49A 1Y7AA 4GTZA 1AUKA 3SZZA 5L0BA 5L0KA 4LR7A 1E1ZP 1HDHA 1KHKA 4LRFA 5IJQA 4CXSA 4ZG6A 3IDDA 3T01A 1KHNA 4CYRA 3M8ZA 3IGZB 1SHQA 3UNYA 1ELXA 5LIAA 1ZEBA 4MY4A 4LRDA 5DLWA 2GSNA 4KM4A 2GA3A 3MK0A 4MIVA 1EW9A 5EGHA 5DLTA 3UN3A 3UN5A 3BDFA 2D1GA 5HRTA 3BDHA 4LRAA 4LR2A 2IUCB 2W5XA 1KH4A 4KAVA 4GTYA 1AJCA 4KAYA 1KH7A 4MHXA 1EW2A 4KJGA 1KHLA 2IFYA 3IGYB 1KH9A 4UPIA 1ELZA 3WAXA 1URAA 1AJAA 2RH6A 3BDGB 4LRCA 3UN2A 1EI6A 1EW8A 2G9YA 2ANHA 4UOOA 4LQYA 1ALIA 2W8SA 3NKRA 3NKQA 1ED9A 1N2KA 3CMRA 3M7VA 4LR9A 4TN0A 5EGEA 3WBHA 5DLVA 4ZG9A 1URBA 2VQRA 4LR8A 5IJSA 5K4PA 5TJ3A 1O99A 2XR9A 4KJDA 3OT9A 1ANJA 1EQJA 4NWJA 1KH5A 4UOPA 3WAYA 4FDJA 1AJBA 3NKPA 4N7TA 3WAVA 3E2DA 1ELYA 4QAXA 1HQAA 2GSOA
chains in the Genus database with same CATH superfamily
3M8WA 5LRMA 4CXKA 2W5SA 3DYCA 3KD8A 4FDIA 2W5RA 4YR1A 2IUCA 3M8YA 2W5QA 3ED4A 5AJ9A 5L0EA 3DPCA 3NVLA 3NKOA 3T00A 3A52A 3SZYA 5LQQA 3MK2A 1O98A 3NKNA 1Y6VA 3LXQA 2X98A 2W5TA 4NWXA 4UPHA 1ZEDA 3TX0A 1FSUA 4LREA 1KHJA 1EJJA 2W5VA 2XRGA 1ZEFA 5GRRA 3NKMA 2GSUA 1E2SP 1B8JA 3BDGA 1ALKA 1ALHA 3Q3QA 5GOVA 4GTWA 1N2LA 4ZGAA 1ALJA 3WAWA 4CYSA 1SHNA 3B5QA 4CXUA 1ANIA 4UORA 3UO0A 1ED8A 1E3CP 5C66A 5LRNA 4UPLA 1HJKA 3MK1A 5INHA 2ZKTA 1E33P 2GLQA 4B56A 3TWZA 2W8DA 4LRBA 2QZUA 4ZG7A 5KXAA 4UPKA 1K7HA 3T02A 4GTXA 1AJDA 2W5WA 3TG0A 1P49A 1Y7AA 4GTZA 1AUKA 3SZZA 5L0BA 5L0KA 4LR7A 1E1ZP 1HDHA 1KHKA 4LRFA 5IJQA 4CXSA 4ZG6A 3IDDA 3T01A 1KHNA 4CYRA 3M8ZA 3IGZB 1SHQA 3UNYA 1ELXA 5LIAA 1ZEBA 4MY4A 4LRDA 5DLWA 2GSNA 4KM4A 2GA3A 3MK0A 4MIVA 1EW9A 5EGHA 5DLTA 3UN3A 3UN5A 3BDFA 2D1GA 5HRTA 3BDHA 4LRAA 4LR2A 2IUCB 2W5XA 1KH4A 4KAVA 4GTYA 1AJCA 4KAYA 1KH7A 4MHXA 1EW2A 4KJGA 1KHLA 2IFYA 3IGYB 1KH9A 4UPIA 1ELZA 3WAXA 1URAA 1AJAA 2RH6A 3BDGB 4LRCA 3UN2A 1EI6A 1EW8A 2G9YA 2ANHA 4UOOA 4LQYA 1ALIA 2W8SA 3NKRA 3NKQA 1ED9A 1N2KA 3CMRA 3M7VA 4LR9A 4TN0A 5EGEA 3WBHA 5DLVA 4ZG9A 1URBA 2VQRA 4LR8A 5IJSA 5K4PA 5TJ3A 1O99A 2XR9A 4KJDA 3OT9A 1ANJA 1EQJA 4NWJA 1KH5A 4UOPA 3WAYA 4FDJA 1AJBA 3NKPA 4N7TA 3WAVA 3E2DA 1ELYA 4QAXA 1HQAA 2GSOA
chains in the Genus database with same CATH topology
3M8WA 5LRMA 4CXKA 2W5SA 3DYCA 3KD8A 4FDIA 2W5RA 4YR1A 2IUCA 3M8YA 2W5QA 3ED4A 5AJ9A 5L0EA 3DPCA 3NVLA 3NKOA 3T00A 3A52A 3SZYA 5LQQA 3MK2A 1O98A 3NKNA 1Y6VA 3LXQA 2X98A 2W5TA 4NWXA 4UPHA 1ZEDA 3TX0A 1FSUA 4LREA 1KHJA 1EJJA 2W5VA 2XRGA 1ZEFA 5GRRA 3NKMA 2GSUA 1E2SP 1B8JA 3BDGA 1ALKA 1ALHA 3Q3QA 5GOVA 4GTWA 1N2LA 4ZGAA 1ALJA 3WAWA 4CYSA 1SHNA 3B5QA 4CXUA 1ANIA 4UORA 3UO0A 1ED8A 1E3CP 5C66A 5LRNA 4UPLA 1HJKA 3MK1A 5INHA 2ZKTA 1E33P 2GLQA 4B56A 3TWZA 2W8DA 4LRBA 2QZUA 4ZG7A 5KXAA 4UPKA 1K7HA 3T02A 4GTXA 1AJDA 2W5WA 3TG0A 1P49A 1Y7AA 4GTZA 1AUKA 3SZZA 5L0BA 5L0KA 4LR7A 1E1ZP 1HDHA 1KHKA 4LRFA 5IJQA 4CXSA 4ZG6A 3IDDA 3T01A 1KHNA 4CYRA 3M8ZA 3IGZB 1SHQA 3UNYA 1ELXA 5LIAA 1ZEBA 4MY4A 4LRDA 5DLWA 2GSNA 4KM4A 2GA3A 3MK0A 4MIVA 1EW9A 5EGHA 5DLTA 3UN3A 3UN5A 3BDFA 2D1GA 5HRTA 3BDHA 4LRAA 4LR2A 2IUCB 2W5XA 1KH4A 4KAVA 4GTYA 1AJCA 4KAYA 1KH7A 4MHXA 1EW2A 4KJGA 1KHLA 2IFYA 3IGYB 1KH9A 4UPIA 1ELZA 3WAXA 1URAA 1AJAA 2RH6A 3BDGB 4LRCA 3UN2A 1EI6A 1EW8A 2G9YA 2ANHA 4UOOA 4LQYA 1ALIA 2W8SA 3NKRA 3NKQA 1ED9A 1N2KA 3CMRA 3M7VA 4LR9A 4TN0A 5EGEA 3WBHA 5DLVA 4ZG9A 1URBA 2VQRA 4LR8A 5IJSA 5K4PA 5TJ3A 1O99A 2XR9A 4KJDA 3OT9A 1ANJA 1EQJA 4NWJA 1KH5A 4UOPA 3WAYA 4FDJA 1AJBA 3NKPA 4N7TA 3WAVA 3E2DA 1ELYA 4QAXA 1HQAA 2GSOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3M8W A;  5LRM A;  4CXK A;  2W5S A;  3DYC A;  3KD8 A;  4FDI A;  2W5R A;  4YR1 A;  2IUC A;  3M8Y A;  2W5Q A;  3ED4 A;  5AJ9 A;  5L0E A;  3DPC A;  3NVL A;  3NKO A;  3T00 A;  3A52 A;  3SZY A;  5LQQ A;  3MK2 A;  1O98 A;  3NKN A;  1Y6V A;  3LXQ A;  2X98 A;  2W5T A;  4NWX A;  4UPH A;  1ZED A;  3TX0 A;  1FSU A;  4LRE A;  1KHJ A;  1EJJ A;  2W5V A;  2XRG A;  1ZEF A;  5GRR A;  3NKM A;  2GSU A;  1E2S P;  1B8J A;  3BDG A;  1ALK A;  1ALH A;  3Q3Q A;  5GOV A;  4GTW A;  1N2L A;  4ZGA A;  1ALJ A;  3WAW A;  4CYS A;  1SHN A;  3B5Q A;  4CXU A;  1ANI A;  4UOR A;  3UO0 A;  1ED8 A;  1E3C P;  5C66 A;  5LRN A;  4UPL A;  1HJK A;  3MK1 A;  5INH A;  2ZKT A;  1E33 P;  2GLQ A;  4B56 A;  3TWZ A;  2W8D A;  4LRB A;  2QZU A;  4ZG7 A;  5KXA A;  4UPK A;  1K7H A;  3T02 A;  4GTX A;  1AJD A;  2W5W A;  3TG0 A;  1P49 A;  1Y7A A;  4GTZ A;  1AUK A;  3SZZ A;  5L0B A;  5L0K A;  4LR7 A;  1E1Z P;  1HDH A;  1KHK A;  4LRF A;  5IJQ A;  4CXS A;  4ZG6 A;  3IDD A;  3T01 A;  1KHN A;  4CYR A;  3M8Z A;  3IGZ B;  1SHQ A;  3UNY A;  1ELX A;  5LIA A;  1ZEB A;  4MY4 A;  4LRD A;  5DLW A;  2GSN A;  4KM4 A;  2GA3 A;  3MK0 A;  4MIV A;  1EW9 A;  5EGH A;  5DLT A;  3UN3 A;  3UN5 A;  3BDF A;  2D1G A;  5HRT A;  3BDH A;  4LRA A;  4LR2 A;  2IUC B;  2W5X A;  1KH4 A;  4KAV A;  4GTY A;  1AJC A;  4KAY A;  1KH7 A;  4MHX A;  1EW2 A;  4KJG A;  1KHL A;  2IFY A;  3IGY B;  1KH9 A;  4UPI A;  1ELZ A;  3WAX A;  1URA A;  1AJA A;  2RH6 A;  3BDG B;  4LRC A;  3UN2 A;  1EI6 A;  1EW8 A;  2G9Y A;  2ANH A;  4UOO A;  4LQY A;  1ALI A;  2W8S A;  3NKR A;  3NKQ A;  1ED9 A;  1N2K A;  3CMR A;  3M7V A;  4LR9 A;  4TN0 A;  5EGE A;  3WBH A;  5DLV A;  4ZG9 A;  1URB A;  2VQR A;  4LR8 A;  5IJS A;  5K4P A;  5TJ3 A;  1O99 A;  2XR9 A;  4KJD A;  3OT9 A;  1ANJ A;  1EQJ A;  4NWJ A;  1KH5 A;  4UOP A;  3WAY A;  4FDJ A;  1AJB A;  3NKP A;  4N7T A;  3WAV A;  3E2D A;  1ELY A;  4QAX A;  1HQA A;  2GSO A; 
#chains in the Genus database with same CATH topology
 3M8W A;  5LRM A;  4CXK A;  2W5S A;  3DYC A;  3KD8 A;  4FDI A;  2W5R A;  4YR1 A;  2IUC A;  3M8Y A;  2W5Q A;  3ED4 A;  5AJ9 A;  5L0E A;  3DPC A;  3NVL A;  3NKO A;  3T00 A;  3A52 A;  3SZY A;  5LQQ A;  3MK2 A;  1O98 A;  3NKN A;  1Y6V A;  3LXQ A;  2X98 A;  2W5T A;  4NWX A;  4UPH A;  1ZED A;  3TX0 A;  1FSU A;  4LRE A;  1KHJ A;  1EJJ A;  2W5V A;  2XRG A;  1ZEF A;  5GRR A;  3NKM A;  2GSU A;  1E2S P;  1B8J A;  3BDG A;  1ALK A;  1ALH A;  3Q3Q A;  5GOV A;  4GTW A;  1N2L A;  4ZGA A;  1ALJ A;  3WAW A;  4CYS A;  1SHN A;  3B5Q A;  4CXU A;  1ANI A;  4UOR A;  3UO0 A;  1ED8 A;  1E3C P;  5C66 A;  5LRN A;  4UPL A;  1HJK A;  3MK1 A;  5INH A;  2ZKT A;  1E33 P;  2GLQ A;  4B56 A;  3TWZ A;  2W8D A;  4LRB A;  2QZU A;  4ZG7 A;  5KXA A;  4UPK A;  1K7H A;  3T02 A;  4GTX A;  1AJD A;  2W5W A;  3TG0 A;  1P49 A;  1Y7A A;  4GTZ A;  1AUK A;  3SZZ A;  5L0B A;  5L0K A;  4LR7 A;  1E1Z P;  1HDH A;  1KHK A;  4LRF A;  5IJQ A;  4CXS A;  4ZG6 A;  3IDD A;  3T01 A;  1KHN A;  4CYR A;  3M8Z A;  3IGZ B;  1SHQ A;  3UNY A;  1ELX A;  5LIA A;  1ZEB A;  4MY4 A;  4LRD A;  5DLW A;  2GSN A;  4KM4 A;  2GA3 A;  3MK0 A;  4MIV A;  1EW9 A;  5EGH A;  5DLT A;  3UN3 A;  3UN5 A;  3BDF A;  2D1G A;  5HRT A;  3BDH A;  4LRA A;  4LR2 A;  2IUC B;  2W5X A;  1KH4 A;  4KAV A;  4GTY A;  1AJC A;  4KAY A;  1KH7 A;  4MHX A;  1EW2 A;  4KJG A;  1KHL A;  2IFY A;  3IGY B;  1KH9 A;  4UPI A;  1ELZ A;  3WAX A;  1URA A;  1AJA A;  2RH6 A;  3BDG B;  4LRC A;  3UN2 A;  1EI6 A;  1EW8 A;  2G9Y A;  2ANH A;  4UOO A;  4LQY A;  1ALI A;  2W8S A;  3NKR A;  3NKQ A;  1ED9 A;  1N2K A;  3CMR A;  3M7V A;  4LR9 A;  4TN0 A;  5EGE A;  3WBH A;  5DLV A;  4ZG9 A;  1URB A;  2VQR A;  4LR8 A;  5IJS A;  5K4P A;  5TJ3 A;  1O99 A;  2XR9 A;  4KJD A;  3OT9 A;  1ANJ A;  1EQJ A;  4NWJ A;  1KH5 A;  4UOP A;  3WAY A;  4FDJ A;  1AJB A;  3NKP A;  4N7T A;  3WAV A;  3E2D A;  1ELY A;  4QAX A;  1HQA A;  2GSO A; 
#chains in the Genus database with same CATH homology
 3M8W A;  5LRM A;  4CXK A;  2W5S A;  3DYC A;  3KD8 A;  4FDI A;  2W5R A;  4YR1 A;  2IUC A;  3M8Y A;  2W5Q A;  3ED4 A;  5AJ9 A;  5L0E A;  3DPC A;  3NVL A;  3NKO A;  3T00 A;  3A52 A;  3SZY A;  5LQQ A;  3MK2 A;  1O98 A;  3NKN A;  1Y6V A;  3LXQ A;  2X98 A;  2W5T A;  4NWX A;  4UPH A;  1ZED A;  3TX0 A;  1FSU A;  4LRE A;  1KHJ A;  1EJJ A;  2W5V A;  2XRG A;  1ZEF A;  5GRR A;  3NKM A;  2GSU A;  1E2S P;  1B8J A;  3BDG A;  1ALK A;  1ALH A;  3Q3Q A;  5GOV A;  4GTW A;  1N2L A;  4ZGA A;  1ALJ A;  3WAW A;  4CYS A;  1SHN A;  3B5Q A;  4CXU A;  1ANI A;  4UOR A;  3UO0 A;  1ED8 A;  1E3C P;  5C66 A;  5LRN A;  4UPL A;  1HJK A;  3MK1 A;  5INH A;  2ZKT A;  1E33 P;  2GLQ A;  4B56 A;  3TWZ A;  2W8D A;  4LRB A;  2QZU A;  4ZG7 A;  5KXA A;  4UPK A;  1K7H A;  3T02 A;  4GTX A;  1AJD A;  2W5W A;  3TG0 A;  1P49 A;  1Y7A A;  4GTZ A;  1AUK A;  3SZZ A;  5L0B A;  5L0K A;  4LR7 A;  1E1Z P;  1HDH A;  1KHK A;  4LRF A;  5IJQ A;  4CXS A;  4ZG6 A;  3IDD A;  3T01 A;  1KHN A;  4CYR A;  3M8Z A;  3IGZ B;  1SHQ A;  3UNY A;  1ELX A;  5LIA A;  1ZEB A;  4MY4 A;  4LRD A;  5DLW A;  2GSN A;  4KM4 A;  2GA3 A;  3MK0 A;  4MIV A;  1EW9 A;  5EGH A;  5DLT A;  3UN3 A;  3UN5 A;  3BDF A;  2D1G A;  5HRT A;  3BDH A;  4LRA A;  4LR2 A;  2IUC B;  2W5X A;  1KH4 A;  4KAV A;  4GTY A;  1AJC A;  4KAY A;  1KH7 A;  4MHX A;  1EW2 A;  4KJG A;  1KHL A;  2IFY A;  3IGY B;  1KH9 A;  4UPI A;  1ELZ A;  3WAX A;  1URA A;  1AJA A;  2RH6 A;  3BDG B;  4LRC A;  3UN2 A;  1EI6 A;  1EW8 A;  2G9Y A;  2ANH A;  4UOO A;  4LQY A;  1ALI A;  2W8S A;  3NKR A;  3NKQ A;  1ED9 A;  1N2K A;  3CMR A;  3M7V A;  4LR9 A;  4TN0 A;  5EGE A;  3WBH A;  5DLV A;  4ZG9 A;  1URB A;  2VQR A;  4LR8 A;  5IJS A;  5K4P A;  5TJ3 A;  1O99 A;  2XR9 A;  4KJD A;  3OT9 A;  1ANJ A;  1EQJ A;  4NWJ A;  1KH5 A;  4UOP A;  3WAY A;  4FDJ A;  1AJB A;  3NKP A;  4N7T A;  3WAV A;  3E2D A;  1ELY A;  4QAX A;  1HQA A;  2GSO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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