3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
1HQAA 3UNYA 5LRMA 5IJSA 4LRFA 1EQJA 5DLVA 4FDJA 3SZYA 5DLWA 4MIVA 1HDHA 5GRRA 2RH6A 4KJDA 3TG0A 4LQYA 1N2LA 3WAXA 5LQQA 2W5TA 1ZEDA 4N7TA 2ANHA 4ZG7A 3BDGA 2G9YA 3CMRA 1EW9A 5GOVA 3SZZA 1EW2A 3E2DA 4GTXA 3WAVA 1KH5A 1ELXA 4LRAA 3MK1A 4CYSA 4ZG6A 4ZGAA 4UPKA 3M8WA 4B56A 5K4PA 1EJJA 4UPIA 3M8ZA 4NWJA 4FDIA 1FSUA 1Y6VA 4MHXA 3UN2A 5KXAA 4GTWA 2XR9A 2IFYA 1O98A 1ALJA 5L0KA 3UN3A 3IGYB 4CXSA 4KAVA 3WAWA 3LXQA 3MK0A 2ZKTA 5TJ3A 5EGEA 5DLTA 2W5SA 3IDDA 4UPLA 3NKQA 1Y7AA 2D1GA 5INHA 2GSNA 2GSOA 3WBHA 4TN0A 1ELYA 1KHLA 1K7HA 4YR1A 1E3CP 2W5XA 1B8JA 4KAYA 1KH7A 1SHNA 5L0EA 1AJAA 4LRBA 2W5WA 1ALIA 1N2KA 2W8DA 2GSUA 5L0BA 4MY4A 4UOOA 5C66A 1P49A 1AJDA 3BDHA 1ANJA 3KD8A 2W5QA 2XRGA 3T00A 2VQRA 1KH9A 1ALKA 3DYCA 3M8YA 3B5QA 5EGHA 3UO0A 1E2SP 2IUCB 1E1ZP 1ED8A 1ZEFA 2W5RA 4KM4A 2X98A 4LR8A 3M7VA 3MK2A 1URAA 4GTZA 4CXKA 1ANIA 4LR7A 2QZUA 4LREA 2GLQA 4LR2A 4GTYA 1ED9A 1AJCA 1E33P 1ELZA 4UOPA 4QAXA 4UORA 3WAYA 4CXUA 3OT9A 5HRTA 4CYRA 1O99A 4KJGA 2W8SA 3T02A 1KHNA 2W5VA 3NKRA 1EW8A 3UN5A 4LRCA 5LIAA 1KHJA 1URBA 3NKNA 1AUKA 3ED4A 3NVLA 3NKMA 3Q3QA 1ALHA 4LR9A 5IJQA 3BDGB 3TWZA 5LRNA 3IGZB 1AJBA 1HJKA 1KH4A 3DPCA 1EI6A 4NWXA 3NKPA 4UPHA 4ZG9A 1KHKA 1SHQA 3NKOA 3T01A 3A52A 2GA3A 3BDFA 2IUCA 5AJ9A 1ZEBA 3TX0A 4LRDA
chains in the Genus database with same CATH superfamily
1HQAA 3UNYA 5LRMA 5IJSA 4LRFA 1EQJA 5DLVA 4FDJA 3SZYA 5DLWA 4MIVA 1HDHA 5GRRA 2RH6A 4KJDA 3TG0A 4LQYA 1N2LA 3WAXA 5LQQA 2W5TA 1ZEDA 4N7TA 2ANHA 4ZG7A 3BDGA 2G9YA 3CMRA 1EW9A 5GOVA 3SZZA 1EW2A 3E2DA 4GTXA 3WAVA 1KH5A 1ELXA 4LRAA 3MK1A 4CYSA 4ZG6A 4ZGAA 4UPKA 3M8WA 4B56A 5K4PA 1EJJA 4UPIA 3M8ZA 4NWJA 4FDIA 1FSUA 1Y6VA 4MHXA 3UN2A 5KXAA 4GTWA 2XR9A 2IFYA 1O98A 1ALJA 5L0KA 3UN3A 3IGYB 4CXSA 4KAVA 3WAWA 3LXQA 3MK0A 2ZKTA 5TJ3A 5EGEA 5DLTA 2W5SA 3IDDA 4UPLA 3NKQA 1Y7AA 2D1GA 5INHA 2GSNA 2GSOA 3WBHA 4TN0A 1ELYA 1KHLA 1K7HA 4YR1A 1E3CP 2W5XA 1B8JA 4KAYA 1KH7A 1SHNA 5L0EA 1AJAA 4LRBA 2W5WA 1ALIA 1N2KA 2W8DA 2GSUA 5L0BA 4MY4A 4UOOA 5C66A 1P49A 1AJDA 3BDHA 1ANJA 3KD8A 2W5QA 2XRGA 3T00A 2VQRA 1KH9A 1ALKA 3DYCA 3M8YA 3B5QA 5EGHA 3UO0A 1E2SP 2IUCB 1E1ZP 1ED8A 1ZEFA 2W5RA 4KM4A 2X98A 4LR8A 3M7VA 3MK2A 1URAA 4GTZA 4CXKA 1ANIA 4LR7A 2QZUA 4LREA 2GLQA 4LR2A 4GTYA 1ED9A 1AJCA 1E33P 1ELZA 4UOPA 4QAXA 4UORA 3WAYA 4CXUA 3OT9A 5HRTA 4CYRA 1O99A 4KJGA 2W8SA 3T02A 1KHNA 2W5VA 3NKRA 1EW8A 3UN5A 4LRCA 5LIAA 1KHJA 1URBA 3NKNA 1AUKA 3ED4A 3NVLA 3NKMA 3Q3QA 1ALHA 4LR9A 5IJQA 3BDGB 3TWZA 5LRNA 3IGZB 1AJBA 1HJKA 1KH4A 3DPCA 1EI6A 4NWXA 3NKPA 4UPHA 4ZG9A 1KHKA 1SHQA 3NKOA 3T01A 3A52A 2GA3A 3BDFA 2IUCA 5AJ9A 1ZEBA 3TX0A 4LRDA
chains in the Genus database with same CATH topology
1HQAA 3UNYA 5LRMA 5IJSA 4LRFA 1EQJA 5DLVA 4FDJA 3SZYA 5DLWA 4MIVA 1HDHA 5GRRA 2RH6A 4KJDA 3TG0A 4LQYA 1N2LA 3WAXA 5LQQA 2W5TA 1ZEDA 4N7TA 2ANHA 4ZG7A 3BDGA 2G9YA 3CMRA 1EW9A 5GOVA 3SZZA 1EW2A 3E2DA 4GTXA 3WAVA 1KH5A 1ELXA 4LRAA 3MK1A 4CYSA 4ZG6A 4ZGAA 4UPKA 3M8WA 4B56A 5K4PA 1EJJA 4UPIA 3M8ZA 4NWJA 4FDIA 1FSUA 1Y6VA 4MHXA 3UN2A 5KXAA 4GTWA 2XR9A 2IFYA 1O98A 1ALJA 5L0KA 3UN3A 3IGYB 4CXSA 4KAVA 3WAWA 3LXQA 3MK0A 2ZKTA 5TJ3A 5EGEA 5DLTA 2W5SA 3IDDA 4UPLA 3NKQA 1Y7AA 2D1GA 5INHA 2GSNA 2GSOA 3WBHA 4TN0A 1ELYA 1KHLA 1K7HA 4YR1A 1E3CP 2W5XA 1B8JA 4KAYA 1KH7A 1SHNA 5L0EA 1AJAA 4LRBA 2W5WA 1ALIA 1N2KA 2W8DA 2GSUA 5L0BA 4MY4A 4UOOA 5C66A 1P49A 1AJDA 3BDHA 1ANJA 3KD8A 2W5QA 2XRGA 3T00A 2VQRA 1KH9A 1ALKA 3DYCA 3M8YA 3B5QA 5EGHA 3UO0A 1E2SP 2IUCB 1E1ZP 1ED8A 1ZEFA 2W5RA 4KM4A 2X98A 4LR8A 3M7VA 3MK2A 1URAA 4GTZA 4CXKA 1ANIA 4LR7A 2QZUA 4LREA 2GLQA 4LR2A 4GTYA 1ED9A 1AJCA 1E33P 1ELZA 4UOPA 4QAXA 4UORA 3WAYA 4CXUA 3OT9A 5HRTA 4CYRA 1O99A 4KJGA 2W8SA 3T02A 1KHNA 2W5VA 3NKRA 1EW8A 3UN5A 4LRCA 5LIAA 1KHJA 1URBA 3NKNA 1AUKA 3ED4A 3NVLA 3NKMA 3Q3QA 1ALHA 4LR9A 5IJQA 3BDGB 3TWZA 5LRNA 3IGZB 1AJBA 1HJKA 1KH4A 3DPCA 1EI6A 4NWXA 3NKPA 4UPHA 4ZG9A 1KHKA 1SHQA 3NKOA 3T01A 3A52A 2GA3A 3BDFA 2IUCA 5AJ9A 1ZEBA 3TX0A 4LRDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HQA A;  3UNY A;  5LRM A;  5IJS A;  4LRF A;  1EQJ A;  5DLV A;  4FDJ A;  3SZY A;  5DLW A;  4MIV A;  1HDH A;  5GRR A;  2RH6 A;  4KJD A;  3TG0 A;  4LQY A;  1N2L A;  3WAX A;  5LQQ A;  2W5T A;  1ZED A;  4N7T A;  2ANH A;  4ZG7 A;  3BDG A;  2G9Y A;  3CMR A;  1EW9 A;  5GOV A;  3SZZ A;  1EW2 A;  3E2D A;  4GTX A;  3WAV A;  1KH5 A;  1ELX A;  4LRA A;  3MK1 A;  4CYS A;  4ZG6 A;  4ZGA A;  4UPK A;  3M8W A;  4B56 A;  5K4P A;  1EJJ A;  4UPI A;  3M8Z A;  4NWJ A;  4FDI A;  1FSU A;  1Y6V A;  4MHX A;  3UN2 A;  5KXA A;  4GTW A;  2XR9 A;  2IFY A;  1O98 A;  1ALJ A;  5L0K A;  3UN3 A;  3IGY B;  4CXS A;  4KAV A;  3WAW A;  3LXQ A;  3MK0 A;  2ZKT A;  5TJ3 A;  5EGE A;  5DLT A;  2W5S A;  3IDD A;  4UPL A;  3NKQ A;  1Y7A A;  2D1G A;  5INH A;  2GSN A;  2GSO A;  3WBH A;  4TN0 A;  1ELY A;  1KHL A;  1K7H A;  4YR1 A;  1E3C P;  2W5X A;  1B8J A;  4KAY A;  1KH7 A;  1SHN A;  5L0E A;  1AJA A;  4LRB A;  2W5W A;  1ALI A;  1N2K A;  2W8D A;  2GSU A;  5L0B A;  4MY4 A;  4UOO A;  5C66 A;  1P49 A;  1AJD A;  3BDH A;  1ANJ A;  3KD8 A;  2W5Q A;  2XRG A;  3T00 A;  2VQR A;  1KH9 A;  1ALK A;  3DYC A;  3M8Y A;  3B5Q A;  5EGH A;  3UO0 A;  1E2S P;  2IUC B;  1E1Z P;  1ED8 A;  1ZEF A;  2W5R A;  4KM4 A;  2X98 A;  4LR8 A;  3M7V A;  3MK2 A;  1URA A;  4GTZ A;  4CXK A;  1ANI A;  4LR7 A;  2QZU A;  4LRE A;  2GLQ A;  4LR2 A;  4GTY A;  1ED9 A;  1AJC A;  1E33 P;  1ELZ A;  4UOP A;  4QAX A;  4UOR A;  3WAY A;  4CXU A;  3OT9 A;  5HRT A;  4CYR A;  1O99 A;  4KJG A;  2W8S A;  3T02 A;  1KHN A;  2W5V A;  3NKR A;  1EW8 A;  3UN5 A;  4LRC A;  5LIA A;  1KHJ A;  1URB A;  3NKN A;  1AUK A;  3ED4 A;  3NVL A;  3NKM A;  3Q3Q A;  1ALH A;  4LR9 A;  5IJQ A;  3BDG B;  3TWZ A;  5LRN A;  3IGZ B;  1AJB A;  1HJK A;  1KH4 A;  3DPC A;  1EI6 A;  4NWX A;  3NKP A;  4UPH A;  4ZG9 A;  1KHK A;  1SHQ A;  3NKO A;  3T01 A;  3A52 A;  2GA3 A;  3BDF A;  2IUC A;  5AJ9 A;  1ZEB A;  3TX0 A;  4LRD A; 
#chains in the Genus database with same CATH topology
 1HQA A;  3UNY A;  5LRM A;  5IJS A;  4LRF A;  1EQJ A;  5DLV A;  4FDJ A;  3SZY A;  5DLW A;  4MIV A;  1HDH A;  5GRR A;  2RH6 A;  4KJD A;  3TG0 A;  4LQY A;  1N2L A;  3WAX A;  5LQQ A;  2W5T A;  1ZED A;  4N7T A;  2ANH A;  4ZG7 A;  3BDG A;  2G9Y A;  3CMR A;  1EW9 A;  5GOV A;  3SZZ A;  1EW2 A;  3E2D A;  4GTX A;  3WAV A;  1KH5 A;  1ELX A;  4LRA A;  3MK1 A;  4CYS A;  4ZG6 A;  4ZGA A;  4UPK A;  3M8W A;  4B56 A;  5K4P A;  1EJJ A;  4UPI A;  3M8Z A;  4NWJ A;  4FDI A;  1FSU A;  1Y6V A;  4MHX A;  3UN2 A;  5KXA A;  4GTW A;  2XR9 A;  2IFY A;  1O98 A;  1ALJ A;  5L0K A;  3UN3 A;  3IGY B;  4CXS A;  4KAV A;  3WAW A;  3LXQ A;  3MK0 A;  2ZKT A;  5TJ3 A;  5EGE A;  5DLT A;  2W5S A;  3IDD A;  4UPL A;  3NKQ A;  1Y7A A;  2D1G A;  5INH A;  2GSN A;  2GSO A;  3WBH A;  4TN0 A;  1ELY A;  1KHL A;  1K7H A;  4YR1 A;  1E3C P;  2W5X A;  1B8J A;  4KAY A;  1KH7 A;  1SHN A;  5L0E A;  1AJA A;  4LRB A;  2W5W A;  1ALI A;  1N2K A;  2W8D A;  2GSU A;  5L0B A;  4MY4 A;  4UOO A;  5C66 A;  1P49 A;  1AJD A;  3BDH A;  1ANJ A;  3KD8 A;  2W5Q A;  2XRG A;  3T00 A;  2VQR A;  1KH9 A;  1ALK A;  3DYC A;  3M8Y A;  3B5Q A;  5EGH A;  3UO0 A;  1E2S P;  2IUC B;  1E1Z P;  1ED8 A;  1ZEF A;  2W5R A;  4KM4 A;  2X98 A;  4LR8 A;  3M7V A;  3MK2 A;  1URA A;  4GTZ A;  4CXK A;  1ANI A;  4LR7 A;  2QZU A;  4LRE A;  2GLQ A;  4LR2 A;  4GTY A;  1ED9 A;  1AJC A;  1E33 P;  1ELZ A;  4UOP A;  4QAX A;  4UOR A;  3WAY A;  4CXU A;  3OT9 A;  5HRT A;  4CYR A;  1O99 A;  4KJG A;  2W8S A;  3T02 A;  1KHN A;  2W5V A;  3NKR A;  1EW8 A;  3UN5 A;  4LRC A;  5LIA A;  1KHJ A;  1URB A;  3NKN A;  1AUK A;  3ED4 A;  3NVL A;  3NKM A;  3Q3Q A;  1ALH A;  4LR9 A;  5IJQ A;  3BDG B;  3TWZ A;  5LRN A;  3IGZ B;  1AJB A;  1HJK A;  1KH4 A;  3DPC A;  1EI6 A;  4NWX A;  3NKP A;  4UPH A;  4ZG9 A;  1KHK A;  1SHQ A;  3NKO A;  3T01 A;  3A52 A;  2GA3 A;  3BDF A;  2IUC A;  5AJ9 A;  1ZEB A;  3TX0 A;  4LRD A; 
#chains in the Genus database with same CATH homology
 1HQA A;  3UNY A;  5LRM A;  5IJS A;  4LRF A;  1EQJ A;  5DLV A;  4FDJ A;  3SZY A;  5DLW A;  4MIV A;  1HDH A;  5GRR A;  2RH6 A;  4KJD A;  3TG0 A;  4LQY A;  1N2L A;  3WAX A;  5LQQ A;  2W5T A;  1ZED A;  4N7T A;  2ANH A;  4ZG7 A;  3BDG A;  2G9Y A;  3CMR A;  1EW9 A;  5GOV A;  3SZZ A;  1EW2 A;  3E2D A;  4GTX A;  3WAV A;  1KH5 A;  1ELX A;  4LRA A;  3MK1 A;  4CYS A;  4ZG6 A;  4ZGA A;  4UPK A;  3M8W A;  4B56 A;  5K4P A;  1EJJ A;  4UPI A;  3M8Z A;  4NWJ A;  4FDI A;  1FSU A;  1Y6V A;  4MHX A;  3UN2 A;  5KXA A;  4GTW A;  2XR9 A;  2IFY A;  1O98 A;  1ALJ A;  5L0K A;  3UN3 A;  3IGY B;  4CXS A;  4KAV A;  3WAW A;  3LXQ A;  3MK0 A;  2ZKT A;  5TJ3 A;  5EGE A;  5DLT A;  2W5S A;  3IDD A;  4UPL A;  3NKQ A;  1Y7A A;  2D1G A;  5INH A;  2GSN A;  2GSO A;  3WBH A;  4TN0 A;  1ELY A;  1KHL A;  1K7H A;  4YR1 A;  1E3C P;  2W5X A;  1B8J A;  4KAY A;  1KH7 A;  1SHN A;  5L0E A;  1AJA A;  4LRB A;  2W5W A;  1ALI A;  1N2K A;  2W8D A;  2GSU A;  5L0B A;  4MY4 A;  4UOO A;  5C66 A;  1P49 A;  1AJD A;  3BDH A;  1ANJ A;  3KD8 A;  2W5Q A;  2XRG A;  3T00 A;  2VQR A;  1KH9 A;  1ALK A;  3DYC A;  3M8Y A;  3B5Q A;  5EGH A;  3UO0 A;  1E2S P;  2IUC B;  1E1Z P;  1ED8 A;  1ZEF A;  2W5R A;  4KM4 A;  2X98 A;  4LR8 A;  3M7V A;  3MK2 A;  1URA A;  4GTZ A;  4CXK A;  1ANI A;  4LR7 A;  2QZU A;  4LRE A;  2GLQ A;  4LR2 A;  4GTY A;  1ED9 A;  1AJC A;  1E33 P;  1ELZ A;  4UOP A;  4QAX A;  4UOR A;  3WAY A;  4CXU A;  3OT9 A;  5HRT A;  4CYR A;  1O99 A;  4KJG A;  2W8S A;  3T02 A;  1KHN A;  2W5V A;  3NKR A;  1EW8 A;  3UN5 A;  4LRC A;  5LIA A;  1KHJ A;  1URB A;  3NKN A;  1AUK A;  3ED4 A;  3NVL A;  3NKM A;  3Q3Q A;  1ALH A;  4LR9 A;  5IJQ A;  3BDG B;  3TWZ A;  5LRN A;  3IGZ B;  1AJB A;  1HJK A;  1KH4 A;  3DPC A;  1EI6 A;  4NWX A;  3NKP A;  4UPH A;  4ZG9 A;  1KHK A;  1SHQ A;  3NKO A;  3T01 A;  3A52 A;  2GA3 A;  3BDF A;  2IUC A;  5AJ9 A;  1ZEB A;  3TX0 A;  4LRD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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