3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
4MIVA 1HJKA 2W5WA 3NKQA 3MK2A 4LRDA 1ANIA 4LR8A 1O98A 2RH6A 4LRCA 1KHJA 3IDDA 1AJBA 4CXKA 5GRRA 4QAXA 4GTYA 4KJGA 4MHXA 4UOOA 3TWZA 2ZKTA 5TJ3A 2GA3A 3T02A 5LRNA 5EGEA 3TX0A 4GTZA 3OT9A 1ELXA 4FDIA 2GSNA 1B8JA 2X98A 2GLQA 5IJSA 3WAVA 1HQAA 4KJDA 2XR9A 1KH9A 2IFYA 5LIAA 4UPLA 2W5SA 5HRTA 1SHNA 4LRBA 4KM4A 1EW8A 3UN5A 1KH4A 1KH5A 1FSUA 4UPIA 1EW2A 3M8YA 3A52A 3NKNA 1SHQA 5INHA 3MK1A 2G9YA 2W5QA 3M7VA 4UOPA 1ED9A 2ANHA 3KD8A 2VQRA 3NKMA 2GSUA 3UNYA 3CMRA 4GTWA 1AJAA 3UN2A 1EI6A 1ALKA 5C66A 3NKPA 1ZEBA 2D1GA 5L0KA 2W8DA 4LREA 1ZEDA 4ZG6A 2W5XA 3NKRA 1AJDA 1N2KA 5K4PA 4NWXA 3WAXA 4LR2A 2W5TA 1E3CP 1KHNA 1ELZA 4UPHA 1N2LA 4LRAA 1K7HA 1KHKA 3BDFA 3Q3QA 1ELYA 2GSOA 3WBHA 1EW9A 1P49A 1Y7AA 3BDHA 2W8SA 4LR9A 1AUKA 3T01A 1EJJA 4NWJA 3UO0A 2XRGA 4N7TA 4YR1A 4ZG9A 4KAVA 3SZYA 3TG0A 5DLWA 3ED4A 1URAA 5KXAA 4GTXA 3BDGB 4UORA 4TN0A 4ZGAA 1URBA 1ZEFA 5LRMA 1ANJA 4FDJA 3UN3A 2IUCA 2QZUA 4LR7A 3IGYB 4CYRA 3T00A 3DYCA 5AJ9A 5L0BA 5L0EA 1ALHA 3NKOA 4KAYA 1ED8A 3E2DA 1E2SP 2W5RA 1Y6VA 3WAWA 4B56A 3B5QA 1ALJA 4LQYA 5LQQA 1EQJA 2W5VA 3LXQA 1KHLA 5GOVA 4ZG7A 4CXUA 4CYSA 3DPCA 2IUCB 3BDGA 3MK0A 1E33P 4MY4A 1O99A 1ALIA 3NVLA 3M8ZA 1E1ZP 4UPKA 5EGHA 3IGZB 5IJQA 4CXSA 3SZZA 5DLVA 3M8WA 1HDHA 5DLTA 1AJCA 1KH7A 4LRFA 3WAYA
chains in the Genus database with same CATH superfamily
4MIVA 1HJKA 2W5WA 3NKQA 3MK2A 4LRDA 1ANIA 4LR8A 1O98A 2RH6A 4LRCA 1KHJA 3IDDA 1AJBA 4CXKA 5GRRA 4QAXA 4GTYA 4KJGA 4MHXA 4UOOA 3TWZA 2ZKTA 5TJ3A 2GA3A 3T02A 5LRNA 5EGEA 3TX0A 4GTZA 3OT9A 1ELXA 4FDIA 2GSNA 1B8JA 2X98A 2GLQA 5IJSA 3WAVA 1HQAA 4KJDA 2XR9A 1KH9A 2IFYA 5LIAA 4UPLA 2W5SA 5HRTA 1SHNA 4LRBA 4KM4A 1EW8A 3UN5A 1KH4A 1KH5A 1FSUA 4UPIA 1EW2A 3M8YA 3A52A 3NKNA 1SHQA 5INHA 3MK1A 2G9YA 2W5QA 3M7VA 4UOPA 1ED9A 2ANHA 3KD8A 2VQRA 3NKMA 2GSUA 3UNYA 3CMRA 4GTWA 1AJAA 3UN2A 1EI6A 1ALKA 5C66A 3NKPA 1ZEBA 2D1GA 5L0KA 2W8DA 4LREA 1ZEDA 4ZG6A 2W5XA 3NKRA 1AJDA 1N2KA 5K4PA 4NWXA 3WAXA 4LR2A 2W5TA 1E3CP 1KHNA 1ELZA 4UPHA 1N2LA 4LRAA 1K7HA 1KHKA 3BDFA 3Q3QA 1ELYA 2GSOA 3WBHA 1EW9A 1P49A 1Y7AA 3BDHA 2W8SA 4LR9A 1AUKA 3T01A 1EJJA 4NWJA 3UO0A 2XRGA 4N7TA 4YR1A 4ZG9A 4KAVA 3SZYA 3TG0A 5DLWA 3ED4A 1URAA 5KXAA 4GTXA 3BDGB 4UORA 4TN0A 4ZGAA 1URBA 1ZEFA 5LRMA 1ANJA 4FDJA 3UN3A 2IUCA 2QZUA 4LR7A 3IGYB 4CYRA 3T00A 3DYCA 5AJ9A 5L0BA 5L0EA 1ALHA 3NKOA 4KAYA 1ED8A 3E2DA 1E2SP 2W5RA 1Y6VA 3WAWA 4B56A 3B5QA 1ALJA 4LQYA 5LQQA 1EQJA 2W5VA 3LXQA 1KHLA 5GOVA 4ZG7A 4CXUA 4CYSA 3DPCA 2IUCB 3BDGA 3MK0A 1E33P 4MY4A 1O99A 1ALIA 3NVLA 3M8ZA 1E1ZP 4UPKA 5EGHA 3IGZB 5IJQA 4CXSA 3SZZA 5DLVA 3M8WA 1HDHA 5DLTA 1AJCA 1KH7A 4LRFA 3WAYA
chains in the Genus database with same CATH topology
4MIVA 1HJKA 2W5WA 3NKQA 3MK2A 4LRDA 1ANIA 4LR8A 1O98A 2RH6A 4LRCA 1KHJA 3IDDA 1AJBA 4CXKA 5GRRA 4QAXA 4GTYA 4KJGA 4MHXA 4UOOA 3TWZA 2ZKTA 5TJ3A 2GA3A 3T02A 5LRNA 5EGEA 3TX0A 4GTZA 3OT9A 1ELXA 4FDIA 2GSNA 1B8JA 2X98A 2GLQA 5IJSA 3WAVA 1HQAA 4KJDA 2XR9A 1KH9A 2IFYA 5LIAA 4UPLA 2W5SA 5HRTA 1SHNA 4LRBA 4KM4A 1EW8A 3UN5A 1KH4A 1KH5A 1FSUA 4UPIA 1EW2A 3M8YA 3A52A 3NKNA 1SHQA 5INHA 3MK1A 2G9YA 2W5QA 3M7VA 4UOPA 1ED9A 2ANHA 3KD8A 2VQRA 3NKMA 2GSUA 3UNYA 3CMRA 4GTWA 1AJAA 3UN2A 1EI6A 1ALKA 5C66A 3NKPA 1ZEBA 2D1GA 5L0KA 2W8DA 4LREA 1ZEDA 4ZG6A 2W5XA 3NKRA 1AJDA 1N2KA 5K4PA 4NWXA 3WAXA 4LR2A 2W5TA 1E3CP 1KHNA 1ELZA 4UPHA 1N2LA 4LRAA 1K7HA 1KHKA 3BDFA 3Q3QA 1ELYA 2GSOA 3WBHA 1EW9A 1P49A 1Y7AA 3BDHA 2W8SA 4LR9A 1AUKA 3T01A 1EJJA 4NWJA 3UO0A 2XRGA 4N7TA 4YR1A 4ZG9A 4KAVA 3SZYA 3TG0A 5DLWA 3ED4A 1URAA 5KXAA 4GTXA 3BDGB 4UORA 4TN0A 4ZGAA 1URBA 1ZEFA 5LRMA 1ANJA 4FDJA 3UN3A 2IUCA 2QZUA 4LR7A 3IGYB 4CYRA 3T00A 3DYCA 5AJ9A 5L0BA 5L0EA 1ALHA 3NKOA 4KAYA 1ED8A 3E2DA 1E2SP 2W5RA 1Y6VA 3WAWA 4B56A 3B5QA 1ALJA 4LQYA 5LQQA 1EQJA 2W5VA 3LXQA 1KHLA 5GOVA 4ZG7A 4CXUA 4CYSA 3DPCA 2IUCB 3BDGA 3MK0A 1E33P 4MY4A 1O99A 1ALIA 3NVLA 3M8ZA 1E1ZP 4UPKA 5EGHA 3IGZB 5IJQA 4CXSA 3SZZA 5DLVA 3M8WA 1HDHA 5DLTA 1AJCA 1KH7A 4LRFA 3WAYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MIV A;  1HJK A;  2W5W A;  3NKQ A;  3MK2 A;  4LRD A;  1ANI A;  4LR8 A;  1O98 A;  2RH6 A;  4LRC A;  1KHJ A;  3IDD A;  1AJB A;  4CXK A;  5GRR A;  4QAX A;  4GTY A;  4KJG A;  4MHX A;  4UOO A;  3TWZ A;  2ZKT A;  5TJ3 A;  2GA3 A;  3T02 A;  5LRN A;  5EGE A;  3TX0 A;  4GTZ A;  3OT9 A;  1ELX A;  4FDI A;  2GSN A;  1B8J A;  2X98 A;  2GLQ A;  5IJS A;  3WAV A;  1HQA A;  4KJD A;  2XR9 A;  1KH9 A;  2IFY A;  5LIA A;  4UPL A;  2W5S A;  5HRT A;  1SHN A;  4LRB A;  4KM4 A;  1EW8 A;  3UN5 A;  1KH4 A;  1KH5 A;  1FSU A;  4UPI A;  1EW2 A;  3M8Y A;  3A52 A;  3NKN A;  1SHQ A;  5INH A;  3MK1 A;  2G9Y A;  2W5Q A;  3M7V A;  4UOP A;  1ED9 A;  2ANH A;  3KD8 A;  2VQR A;  3NKM A;  2GSU A;  3UNY A;  3CMR A;  4GTW A;  1AJA A;  3UN2 A;  1EI6 A;  1ALK A;  5C66 A;  3NKP A;  1ZEB A;  2D1G A;  5L0K A;  2W8D A;  4LRE A;  1ZED A;  4ZG6 A;  2W5X A;  3NKR A;  1AJD A;  1N2K A;  5K4P A;  4NWX A;  3WAX A;  4LR2 A;  2W5T A;  1E3C P;  1KHN A;  1ELZ A;  4UPH A;  1N2L A;  4LRA A;  1K7H A;  1KHK A;  3BDF A;  3Q3Q A;  1ELY A;  2GSO A;  3WBH A;  1EW9 A;  1P49 A;  1Y7A A;  3BDH A;  2W8S A;  4LR9 A;  1AUK A;  3T01 A;  1EJJ A;  4NWJ A;  3UO0 A;  2XRG A;  4N7T A;  4YR1 A;  4ZG9 A;  4KAV A;  3SZY A;  3TG0 A;  5DLW A;  3ED4 A;  1URA A;  5KXA A;  4GTX A;  3BDG B;  4UOR A;  4TN0 A;  4ZGA A;  1URB A;  1ZEF A;  5LRM A;  1ANJ A;  4FDJ A;  3UN3 A;  2IUC A;  2QZU A;  4LR7 A;  3IGY B;  4CYR A;  3T00 A;  3DYC A;  5AJ9 A;  5L0B A;  5L0E A;  1ALH A;  3NKO A;  4KAY A;  1ED8 A;  3E2D A;  1E2S P;  2W5R A;  1Y6V A;  3WAW A;  4B56 A;  3B5Q A;  1ALJ A;  4LQY A;  5LQQ A;  1EQJ A;  2W5V A;  3LXQ A;  1KHL A;  5GOV A;  4ZG7 A;  4CXU A;  4CYS A;  3DPC A;  2IUC B;  3BDG A;  3MK0 A;  1E33 P;  4MY4 A;  1O99 A;  1ALI A;  3NVL A;  3M8Z A;  1E1Z P;  4UPK A;  5EGH A;  3IGZ B;  5IJQ A;  4CXS A;  3SZZ A;  5DLV A;  3M8W A;  1HDH A;  5DLT A;  1AJC A;  1KH7 A;  4LRF A;  3WAY A; 
#chains in the Genus database with same CATH topology
 4MIV A;  1HJK A;  2W5W A;  3NKQ A;  3MK2 A;  4LRD A;  1ANI A;  4LR8 A;  1O98 A;  2RH6 A;  4LRC A;  1KHJ A;  3IDD A;  1AJB A;  4CXK A;  5GRR A;  4QAX A;  4GTY A;  4KJG A;  4MHX A;  4UOO A;  3TWZ A;  2ZKT A;  5TJ3 A;  2GA3 A;  3T02 A;  5LRN A;  5EGE A;  3TX0 A;  4GTZ A;  3OT9 A;  1ELX A;  4FDI A;  2GSN A;  1B8J A;  2X98 A;  2GLQ A;  5IJS A;  3WAV A;  1HQA A;  4KJD A;  2XR9 A;  1KH9 A;  2IFY A;  5LIA A;  4UPL A;  2W5S A;  5HRT A;  1SHN A;  4LRB A;  4KM4 A;  1EW8 A;  3UN5 A;  1KH4 A;  1KH5 A;  1FSU A;  4UPI A;  1EW2 A;  3M8Y A;  3A52 A;  3NKN A;  1SHQ A;  5INH A;  3MK1 A;  2G9Y A;  2W5Q A;  3M7V A;  4UOP A;  1ED9 A;  2ANH A;  3KD8 A;  2VQR A;  3NKM A;  2GSU A;  3UNY A;  3CMR A;  4GTW A;  1AJA A;  3UN2 A;  1EI6 A;  1ALK A;  5C66 A;  3NKP A;  1ZEB A;  2D1G A;  5L0K A;  2W8D A;  4LRE A;  1ZED A;  4ZG6 A;  2W5X A;  3NKR A;  1AJD A;  1N2K A;  5K4P A;  4NWX A;  3WAX A;  4LR2 A;  2W5T A;  1E3C P;  1KHN A;  1ELZ A;  4UPH A;  1N2L A;  4LRA A;  1K7H A;  1KHK A;  3BDF A;  3Q3Q A;  1ELY A;  2GSO A;  3WBH A;  1EW9 A;  1P49 A;  1Y7A A;  3BDH A;  2W8S A;  4LR9 A;  1AUK A;  3T01 A;  1EJJ A;  4NWJ A;  3UO0 A;  2XRG A;  4N7T A;  4YR1 A;  4ZG9 A;  4KAV A;  3SZY A;  3TG0 A;  5DLW A;  3ED4 A;  1URA A;  5KXA A;  4GTX A;  3BDG B;  4UOR A;  4TN0 A;  4ZGA A;  1URB A;  1ZEF A;  5LRM A;  1ANJ A;  4FDJ A;  3UN3 A;  2IUC A;  2QZU A;  4LR7 A;  3IGY B;  4CYR A;  3T00 A;  3DYC A;  5AJ9 A;  5L0B A;  5L0E A;  1ALH A;  3NKO A;  4KAY A;  1ED8 A;  3E2D A;  1E2S P;  2W5R A;  1Y6V A;  3WAW A;  4B56 A;  3B5Q A;  1ALJ A;  4LQY A;  5LQQ A;  1EQJ A;  2W5V A;  3LXQ A;  1KHL A;  5GOV A;  4ZG7 A;  4CXU A;  4CYS A;  3DPC A;  2IUC B;  3BDG A;  3MK0 A;  1E33 P;  4MY4 A;  1O99 A;  1ALI A;  3NVL A;  3M8Z A;  1E1Z P;  4UPK A;  5EGH A;  3IGZ B;  5IJQ A;  4CXS A;  3SZZ A;  5DLV A;  3M8W A;  1HDH A;  5DLT A;  1AJC A;  1KH7 A;  4LRF A;  3WAY A; 
#chains in the Genus database with same CATH homology
 4MIV A;  1HJK A;  2W5W A;  3NKQ A;  3MK2 A;  4LRD A;  1ANI A;  4LR8 A;  1O98 A;  2RH6 A;  4LRC A;  1KHJ A;  3IDD A;  1AJB A;  4CXK A;  5GRR A;  4QAX A;  4GTY A;  4KJG A;  4MHX A;  4UOO A;  3TWZ A;  2ZKT A;  5TJ3 A;  2GA3 A;  3T02 A;  5LRN A;  5EGE A;  3TX0 A;  4GTZ A;  3OT9 A;  1ELX A;  4FDI A;  2GSN A;  1B8J A;  2X98 A;  2GLQ A;  5IJS A;  3WAV A;  1HQA A;  4KJD A;  2XR9 A;  1KH9 A;  2IFY A;  5LIA A;  4UPL A;  2W5S A;  5HRT A;  1SHN A;  4LRB A;  4KM4 A;  1EW8 A;  3UN5 A;  1KH4 A;  1KH5 A;  1FSU A;  4UPI A;  1EW2 A;  3M8Y A;  3A52 A;  3NKN A;  1SHQ A;  5INH A;  3MK1 A;  2G9Y A;  2W5Q A;  3M7V A;  4UOP A;  1ED9 A;  2ANH A;  3KD8 A;  2VQR A;  3NKM A;  2GSU A;  3UNY A;  3CMR A;  4GTW A;  1AJA A;  3UN2 A;  1EI6 A;  1ALK A;  5C66 A;  3NKP A;  1ZEB A;  2D1G A;  5L0K A;  2W8D A;  4LRE A;  1ZED A;  4ZG6 A;  2W5X A;  3NKR A;  1AJD A;  1N2K A;  5K4P A;  4NWX A;  3WAX A;  4LR2 A;  2W5T A;  1E3C P;  1KHN A;  1ELZ A;  4UPH A;  1N2L A;  4LRA A;  1K7H A;  1KHK A;  3BDF A;  3Q3Q A;  1ELY A;  2GSO A;  3WBH A;  1EW9 A;  1P49 A;  1Y7A A;  3BDH A;  2W8S A;  4LR9 A;  1AUK A;  3T01 A;  1EJJ A;  4NWJ A;  3UO0 A;  2XRG A;  4N7T A;  4YR1 A;  4ZG9 A;  4KAV A;  3SZY A;  3TG0 A;  5DLW A;  3ED4 A;  1URA A;  5KXA A;  4GTX A;  3BDG B;  4UOR A;  4TN0 A;  4ZGA A;  1URB A;  1ZEF A;  5LRM A;  1ANJ A;  4FDJ A;  3UN3 A;  2IUC A;  2QZU A;  4LR7 A;  3IGY B;  4CYR A;  3T00 A;  3DYC A;  5AJ9 A;  5L0B A;  5L0E A;  1ALH A;  3NKO A;  4KAY A;  1ED8 A;  3E2D A;  1E2S P;  2W5R A;  1Y6V A;  3WAW A;  4B56 A;  3B5Q A;  1ALJ A;  4LQY A;  5LQQ A;  1EQJ A;  2W5V A;  3LXQ A;  1KHL A;  5GOV A;  4ZG7 A;  4CXU A;  4CYS A;  3DPC A;  2IUC B;  3BDG A;  3MK0 A;  1E33 P;  4MY4 A;  1O99 A;  1ALI A;  3NVL A;  3M8Z A;  1E1Z P;  4UPK A;  5EGH A;  3IGZ B;  5IJQ A;  4CXS A;  3SZZ A;  5DLV A;  3M8W A;  1HDH A;  5DLT A;  1AJC A;  1KH7 A;  4LRF A;  3WAY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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