3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
b'PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
1E1ZP 2W5RA 3LXQA 2W8DA 2XRGA 4LREA 2GA3A 1ALHA 4QAXA 4TN0A 1SHNA 2GSUA 3KD8A 4KAYA 1EQJA 1EW2A 5K4PA 4KJDA 1EJJA 4NWXA 1KHKA 4GTWA 2W5QA 5GOVA 4ZGAA 4CXSA 3BDHA 4GTXA 2VQRA 3OT9A 4UOPA 4UPIA 3DYCA 4GTZA 5EGHA 5DLVA 2X98A 4MY4A 5LRMA 4CXUA 3NKPA 5IJQA 1P49A 1KHJA 3WAWA 3WAVA 3TWZA 5INHA 1AJCA 5LRNA 4LQYA 3WBHA 4KAVA 3UNYA 3M7VA 4LR7A 5L0EA 4LRDA 2GLQA 3E2DA 3M8WA 2W5VA 3Q3QA 5LIAA 2RH6A 1HDHA 5KXAA 4FDJA 3BDGB 3BDGA 3NKOA 4CYRA 1ANJA 1Y7AA 1EW9A 2D1GA 4LRBA 1N2KA 1AJAA 3IDDA 1EI6A 1AUKA 1ELZA 4N7TA 3IGYB 5L0KA 2W5TA 3UN5A 3T00A 1E3CP 1ALJA 2W5WA 4UPHA 4UPLA 1K7HA 3UN3A 3A52A 1KHLA 3SZZA 3IGZB 3NKRA 1ZEFA 3NVLA 1EW8A 5AJ9A 1FSUA 4KJGA 3ED4A 1URAA 1ED9A 5EGEA 4FDIA 1ZEBA 2G9YA 1O98A 1AJBA 3M8ZA 4LR8A 4KM4A 1ELXA 1ANIA 3NKMA 4ZG9A 4CXKA 4MIVA 3TX0A 3MK0A 4MHXA 1ZEDA 3TG0A 3DPCA 4LRFA 3MK2A 3WAXA 3M8YA 4CYSA 4LR2A 1KH5A 1KH7A 5DLTA 4ZG7A 3UO0A 1ED8A 2GSOA 3T02A 1KH4A 2IFYA 1ALIA 1KH9A 1Y6VA 4UPKA 2W5SA 5IJSA 5DLWA 1E2SP 3WAYA 4ZG6A 5L0BA 3BDFA 4LR9A 3NKQA 4UOOA 1ELYA 4NWJA 2ZKTA 5TJ3A 2W5XA 2W8SA 2IUCB 2IUCA 4UORA 4YR1A 3UN2A 4GTYA 1E33P 3SZYA 5LQQA 1B8JA 1KHNA 1ALKA 3T01A 5HRTA 1N2LA 2XR9A 3MK1A 2ANHA 4B56A 4LRCA 1SHQA 3NKNA 5GRRA 3CMRA 1URBA 5C66A 2QZUA 3B5QA 4LRAA 1HJKA 1AJDA 2GSNA 1O99A 1HQAA
chains in the Genus database with same CATH superfamily
1E1ZP 2W5RA 3LXQA 2W8DA 2XRGA 4LREA 2GA3A 1ALHA 4QAXA 4TN0A 1SHNA 2GSUA 3KD8A 4KAYA 1EQJA 1EW2A 5K4PA 4KJDA 1EJJA 4NWXA 1KHKA 4GTWA 2W5QA 5GOVA 4ZGAA 4CXSA 3BDHA 4GTXA 2VQRA 3OT9A 4UOPA 4UPIA 3DYCA 4GTZA 5EGHA 5DLVA 2X98A 4MY4A 5LRMA 4CXUA 3NKPA 5IJQA 1P49A 1KHJA 3WAWA 3WAVA 3TWZA 5INHA 1AJCA 5LRNA 4LQYA 3WBHA 4KAVA 3UNYA 3M7VA 4LR7A 5L0EA 4LRDA 2GLQA 3E2DA 3M8WA 2W5VA 3Q3QA 5LIAA 2RH6A 1HDHA 5KXAA 4FDJA 3BDGB 3BDGA 3NKOA 4CYRA 1ANJA 1Y7AA 1EW9A 2D1GA 4LRBA 1N2KA 1AJAA 3IDDA 1EI6A 1AUKA 1ELZA 4N7TA 3IGYB 5L0KA 2W5TA 3UN5A 3T00A 1E3CP 1ALJA 2W5WA 4UPHA 4UPLA 1K7HA 3UN3A 3A52A 1KHLA 3SZZA 3IGZB 3NKRA 1ZEFA 3NVLA 1EW8A 5AJ9A 1FSUA 4KJGA 3ED4A 1URAA 1ED9A 5EGEA 4FDIA 1ZEBA 2G9YA 1O98A 1AJBA 3M8ZA 4LR8A 4KM4A 1ELXA 1ANIA 3NKMA 4ZG9A 4CXKA 4MIVA 3TX0A 3MK0A 4MHXA 1ZEDA 3TG0A 3DPCA 4LRFA 3MK2A 3WAXA 3M8YA 4CYSA 4LR2A 1KH5A 1KH7A 5DLTA 4ZG7A 3UO0A 1ED8A 2GSOA 3T02A 1KH4A 2IFYA 1ALIA 1KH9A 1Y6VA 4UPKA 2W5SA 5IJSA 5DLWA 1E2SP 3WAYA 4ZG6A 5L0BA 3BDFA 4LR9A 3NKQA 4UOOA 1ELYA 4NWJA 2ZKTA 5TJ3A 2W5XA 2W8SA 2IUCB 2IUCA 4UORA 4YR1A 3UN2A 4GTYA 1E33P 3SZYA 5LQQA 1B8JA 1KHNA 1ALKA 3T01A 5HRTA 1N2LA 2XR9A 3MK1A 2ANHA 4B56A 4LRCA 1SHQA 3NKNA 5GRRA 3CMRA 1URBA 5C66A 2QZUA 3B5QA 4LRAA 1HJKA 1AJDA 2GSNA 1O99A 1HQAA
chains in the Genus database with same CATH topology
1E1ZP 2W5RA 3LXQA 2W8DA 2XRGA 4LREA 2GA3A 1ALHA 4QAXA 4TN0A 1SHNA 2GSUA 3KD8A 4KAYA 1EQJA 1EW2A 5K4PA 4KJDA 1EJJA 4NWXA 1KHKA 4GTWA 2W5QA 5GOVA 4ZGAA 4CXSA 3BDHA 4GTXA 2VQRA 3OT9A 4UOPA 4UPIA 3DYCA 4GTZA 5EGHA 5DLVA 2X98A 4MY4A 5LRMA 4CXUA 3NKPA 5IJQA 1P49A 1KHJA 3WAWA 3WAVA 3TWZA 5INHA 1AJCA 5LRNA 4LQYA 3WBHA 4KAVA 3UNYA 3M7VA 4LR7A 5L0EA 4LRDA 2GLQA 3E2DA 3M8WA 2W5VA 3Q3QA 5LIAA 2RH6A 1HDHA 5KXAA 4FDJA 3BDGB 3BDGA 3NKOA 4CYRA 1ANJA 1Y7AA 1EW9A 2D1GA 4LRBA 1N2KA 1AJAA 3IDDA 1EI6A 1AUKA 1ELZA 4N7TA 3IGYB 5L0KA 2W5TA 3UN5A 3T00A 1E3CP 1ALJA 2W5WA 4UPHA 4UPLA 1K7HA 3UN3A 3A52A 1KHLA 3SZZA 3IGZB 3NKRA 1ZEFA 3NVLA 1EW8A 5AJ9A 1FSUA 4KJGA 3ED4A 1URAA 1ED9A 5EGEA 4FDIA 1ZEBA 2G9YA 1O98A 1AJBA 3M8ZA 4LR8A 4KM4A 1ELXA 1ANIA 3NKMA 4ZG9A 4CXKA 4MIVA 3TX0A 3MK0A 4MHXA 1ZEDA 3TG0A 3DPCA 4LRFA 3MK2A 3WAXA 3M8YA 4CYSA 4LR2A 1KH5A 1KH7A 5DLTA 4ZG7A 3UO0A 1ED8A 2GSOA 3T02A 1KH4A 2IFYA 1ALIA 1KH9A 1Y6VA 4UPKA 2W5SA 5IJSA 5DLWA 1E2SP 3WAYA 4ZG6A 5L0BA 3BDFA 4LR9A 3NKQA 4UOOA 1ELYA 4NWJA 2ZKTA 5TJ3A 2W5XA 2W8SA 2IUCB 2IUCA 4UORA 4YR1A 3UN2A 4GTYA 1E33P 3SZYA 5LQQA 1B8JA 1KHNA 1ALKA 3T01A 5HRTA 1N2LA 2XR9A 3MK1A 2ANHA 4B56A 4LRCA 1SHQA 3NKNA 5GRRA 3CMRA 1URBA 5C66A 2QZUA 3B5QA 4LRAA 1HJKA 1AJDA 2GSNA 1O99A 1HQAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E1Z P;  2W5R A;  3LXQ A;  2W8D A;  2XRG A;  4LRE A;  2GA3 A;  1ALH A;  4QAX A;  4TN0 A;  1SHN A;  2GSU A;  3KD8 A;  4KAY A;  1EQJ A;  1EW2 A;  5K4P A;  4KJD A;  1EJJ A;  4NWX A;  1KHK A;  4GTW A;  2W5Q A;  5GOV A;  4ZGA A;  4CXS A;  3BDH A;  4GTX A;  2VQR A;  3OT9 A;  4UOP A;  4UPI A;  3DYC A;  4GTZ A;  5EGH A;  5DLV A;  2X98 A;  4MY4 A;  5LRM A;  4CXU A;  3NKP A;  5IJQ A;  1P49 A;  1KHJ A;  3WAW A;  3WAV A;  3TWZ A;  5INH A;  1AJC A;  5LRN A;  4LQY A;  3WBH A;  4KAV A;  3UNY A;  3M7V A;  4LR7 A;  5L0E A;  4LRD A;  2GLQ A;  3E2D A;  3M8W A;  2W5V A;  3Q3Q A;  5LIA A;  2RH6 A;  1HDH A;  5KXA A;  4FDJ A;  3BDG B;  3BDG A;  3NKO A;  4CYR A;  1ANJ A;  1Y7A A;  1EW9 A;  2D1G A;  4LRB A;  1N2K A;  1AJA A;  3IDD A;  1EI6 A;  1AUK A;  1ELZ A;  4N7T A;  3IGY B;  5L0K A;  2W5T A;  3UN5 A;  3T00 A;  1E3C P;  1ALJ A;  2W5W A;  4UPH A;  4UPL A;  1K7H A;  3UN3 A;  3A52 A;  1KHL A;  3SZZ A;  3IGZ B;  3NKR A;  1ZEF A;  3NVL A;  1EW8 A;  5AJ9 A;  1FSU A;  4KJG A;  3ED4 A;  1URA A;  1ED9 A;  5EGE A;  4FDI A;  1ZEB A;  2G9Y A;  1O98 A;  1AJB A;  3M8Z A;  4LR8 A;  4KM4 A;  1ELX A;  1ANI A;  3NKM A;  4ZG9 A;  4CXK A;  4MIV A;  3TX0 A;  3MK0 A;  4MHX A;  1ZED A;  3TG0 A;  3DPC A;  4LRF A;  3MK2 A;  3WAX A;  3M8Y A;  4CYS A;  4LR2 A;  1KH5 A;  1KH7 A;  5DLT A;  4ZG7 A;  3UO0 A;  1ED8 A;  2GSO A;  3T02 A;  1KH4 A;  2IFY A;  1ALI A;  1KH9 A;  1Y6V A;  4UPK A;  2W5S A;  5IJS A;  5DLW A;  1E2S P;  3WAY A;  4ZG6 A;  5L0B A;  3BDF A;  4LR9 A;  3NKQ A;  4UOO A;  1ELY A;  4NWJ A;  2ZKT A;  5TJ3 A;  2W5X A;  2W8S A;  2IUC B;  2IUC A;  4UOR A;  4YR1 A;  3UN2 A;  4GTY A;  1E33 P;  3SZY A;  5LQQ A;  1B8J A;  1KHN A;  1ALK A;  3T01 A;  5HRT A;  1N2L A;  2XR9 A;  3MK1 A;  2ANH A;  4B56 A;  4LRC A;  1SHQ A;  3NKN A;  5GRR A;  3CMR A;  1URB A;  5C66 A;  2QZU A;  3B5Q A;  4LRA A;  1HJK A;  1AJD A;  2GSN A;  1O99 A;  1HQA A; 
#chains in the Genus database with same CATH topology
 1E1Z P;  2W5R A;  3LXQ A;  2W8D A;  2XRG A;  4LRE A;  2GA3 A;  1ALH A;  4QAX A;  4TN0 A;  1SHN A;  2GSU A;  3KD8 A;  4KAY A;  1EQJ A;  1EW2 A;  5K4P A;  4KJD A;  1EJJ A;  4NWX A;  1KHK A;  4GTW A;  2W5Q A;  5GOV A;  4ZGA A;  4CXS A;  3BDH A;  4GTX A;  2VQR A;  3OT9 A;  4UOP A;  4UPI A;  3DYC A;  4GTZ A;  5EGH A;  5DLV A;  2X98 A;  4MY4 A;  5LRM A;  4CXU A;  3NKP A;  5IJQ A;  1P49 A;  1KHJ A;  3WAW A;  3WAV A;  3TWZ A;  5INH A;  1AJC A;  5LRN A;  4LQY A;  3WBH A;  4KAV A;  3UNY A;  3M7V A;  4LR7 A;  5L0E A;  4LRD A;  2GLQ A;  3E2D A;  3M8W A;  2W5V A;  3Q3Q A;  5LIA A;  2RH6 A;  1HDH A;  5KXA A;  4FDJ A;  3BDG B;  3BDG A;  3NKO A;  4CYR A;  1ANJ A;  1Y7A A;  1EW9 A;  2D1G A;  4LRB A;  1N2K A;  1AJA A;  3IDD A;  1EI6 A;  1AUK A;  1ELZ A;  4N7T A;  3IGY B;  5L0K A;  2W5T A;  3UN5 A;  3T00 A;  1E3C P;  1ALJ A;  2W5W A;  4UPH A;  4UPL A;  1K7H A;  3UN3 A;  3A52 A;  1KHL A;  3SZZ A;  3IGZ B;  3NKR A;  1ZEF A;  3NVL A;  1EW8 A;  5AJ9 A;  1FSU A;  4KJG A;  3ED4 A;  1URA A;  1ED9 A;  5EGE A;  4FDI A;  1ZEB A;  2G9Y A;  1O98 A;  1AJB A;  3M8Z A;  4LR8 A;  4KM4 A;  1ELX A;  1ANI A;  3NKM A;  4ZG9 A;  4CXK A;  4MIV A;  3TX0 A;  3MK0 A;  4MHX A;  1ZED A;  3TG0 A;  3DPC A;  4LRF A;  3MK2 A;  3WAX A;  3M8Y A;  4CYS A;  4LR2 A;  1KH5 A;  1KH7 A;  5DLT A;  4ZG7 A;  3UO0 A;  1ED8 A;  2GSO A;  3T02 A;  1KH4 A;  2IFY A;  1ALI A;  1KH9 A;  1Y6V A;  4UPK A;  2W5S A;  5IJS A;  5DLW A;  1E2S P;  3WAY A;  4ZG6 A;  5L0B A;  3BDF A;  4LR9 A;  3NKQ A;  4UOO A;  1ELY A;  4NWJ A;  2ZKT A;  5TJ3 A;  2W5X A;  2W8S A;  2IUC B;  2IUC A;  4UOR A;  4YR1 A;  3UN2 A;  4GTY A;  1E33 P;  3SZY A;  5LQQ A;  1B8J A;  1KHN A;  1ALK A;  3T01 A;  5HRT A;  1N2L A;  2XR9 A;  3MK1 A;  2ANH A;  4B56 A;  4LRC A;  1SHQ A;  3NKN A;  5GRR A;  3CMR A;  1URB A;  5C66 A;  2QZU A;  3B5Q A;  4LRA A;  1HJK A;  1AJD A;  2GSN A;  1O99 A;  1HQA A; 
#chains in the Genus database with same CATH homology
 1E1Z P;  2W5R A;  3LXQ A;  2W8D A;  2XRG A;  4LRE A;  2GA3 A;  1ALH A;  4QAX A;  4TN0 A;  1SHN A;  2GSU A;  3KD8 A;  4KAY A;  1EQJ A;  1EW2 A;  5K4P A;  4KJD A;  1EJJ A;  4NWX A;  1KHK A;  4GTW A;  2W5Q A;  5GOV A;  4ZGA A;  4CXS A;  3BDH A;  4GTX A;  2VQR A;  3OT9 A;  4UOP A;  4UPI A;  3DYC A;  4GTZ A;  5EGH A;  5DLV A;  2X98 A;  4MY4 A;  5LRM A;  4CXU A;  3NKP A;  5IJQ A;  1P49 A;  1KHJ A;  3WAW A;  3WAV A;  3TWZ A;  5INH A;  1AJC A;  5LRN A;  4LQY A;  3WBH A;  4KAV A;  3UNY A;  3M7V A;  4LR7 A;  5L0E A;  4LRD A;  2GLQ A;  3E2D A;  3M8W A;  2W5V A;  3Q3Q A;  5LIA A;  2RH6 A;  1HDH A;  5KXA A;  4FDJ A;  3BDG B;  3BDG A;  3NKO A;  4CYR A;  1ANJ A;  1Y7A A;  1EW9 A;  2D1G A;  4LRB A;  1N2K A;  1AJA A;  3IDD A;  1EI6 A;  1AUK A;  1ELZ A;  4N7T A;  3IGY B;  5L0K A;  2W5T A;  3UN5 A;  3T00 A;  1E3C P;  1ALJ A;  2W5W A;  4UPH A;  4UPL A;  1K7H A;  3UN3 A;  3A52 A;  1KHL A;  3SZZ A;  3IGZ B;  3NKR A;  1ZEF A;  3NVL A;  1EW8 A;  5AJ9 A;  1FSU A;  4KJG A;  3ED4 A;  1URA A;  1ED9 A;  5EGE A;  4FDI A;  1ZEB A;  2G9Y A;  1O98 A;  1AJB A;  3M8Z A;  4LR8 A;  4KM4 A;  1ELX A;  1ANI A;  3NKM A;  4ZG9 A;  4CXK A;  4MIV A;  3TX0 A;  3MK0 A;  4MHX A;  1ZED A;  3TG0 A;  3DPC A;  4LRF A;  3MK2 A;  3WAX A;  3M8Y A;  4CYS A;  4LR2 A;  1KH5 A;  1KH7 A;  5DLT A;  4ZG7 A;  3UO0 A;  1ED8 A;  2GSO A;  3T02 A;  1KH4 A;  2IFY A;  1ALI A;  1KH9 A;  1Y6V A;  4UPK A;  2W5S A;  5IJS A;  5DLW A;  1E2S P;  3WAY A;  4ZG6 A;  5L0B A;  3BDF A;  4LR9 A;  3NKQ A;  4UOO A;  1ELY A;  4NWJ A;  2ZKT A;  5TJ3 A;  2W5X A;  2W8S A;  2IUC B;  2IUC A;  4UOR A;  4YR1 A;  3UN2 A;  4GTY A;  1E33 P;  3SZY A;  5LQQ A;  1B8J A;  1KHN A;  1ALK A;  3T01 A;  5HRT A;  1N2L A;  2XR9 A;  3MK1 A;  2ANH A;  4B56 A;  4LRC A;  1SHQ A;  3NKN A;  5GRR A;  3CMR A;  1URB A;  5C66 A;  2QZU A;  3B5Q A;  4LRA A;  1HJK A;  1AJD A;  2GSN A;  1O99 A;  1HQA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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