3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
1ED8A 1KHNA 1P49A 1ELZA 3ED4A 3WAVA 2ZKTA 4MHXA 3BDGA 3M8YA 5L0BA 3M8ZA 3WAXA 1N2KA 1ANIA 4UPIA 5GOVA 5GRRA 2W8DA 1KHKA 3T01A 4LRFA 4LR9A 2W5WA 2W5QA 1ZEDA 2GSUA 3BDHA 4UPHA 1KH9A 3NKNA 1N2LA 1E33P 4NWXA 5EGHA 4GTWA 4UORA 2W5VA 5KXAA 4B56A 2VQRA 5DLWA 4ZG6A 1AJCA 1E1ZP 3MK0A 1O98A 2IFYA 2W8SA 4MY4A 4LRAA 3SZYA 1KH7A 3B5QA 1Y7AA 4N7TA 1AJBA 3CMRA 4GTYA 4KAYA 5DLTA 5C66A 1EQJA 4ZGAA 3NKRA 3UNYA 5LRMA 2QZUA 1HDHA 3T00A 5DLVA 3TX0A 2GA3A 4CXUA 3WAYA 3UN2A 5LQQA 1ZEBA 1FSUA 5INHA 1ALHA 4LR8A 4GTXA 1KHJA 3NKQA 4ZG9A 3WAWA 4NWJA 2W5XA 3IDDA 3Q3QA 4LRDA 3T02A 1EI6A 2D1GA 1O99A 2ANHA 5LIAA 3MK1A 1ELYA 4CYSA 2XR9A 4LR7A 4UOOA 4CXSA 1EJJA 4QAXA 3TG0A 1AJAA 3BDGB 5L0EA 3A52A 3TWZA 1HJKA 3M8WA 1EW8A 4GTZA 3WBHA 4YR1A 5TJ3A 5EGEA 4LRBA 1ALKA 4UOPA 2IUCA 2XRGA 3NVLA 4UPLA 1SHNA 4KAVA 1ZEFA 4LQYA 1KH4A 2GSNA 2W5SA 4CYRA 3NKOA 1B8JA 3IGZB 5HRTA 1URBA 4ZG7A 4UPKA 3LXQA 3UN3A 1HQAA 1URAA 1AUKA 1KHLA 4TN0A 5K4PA 1K7HA 3E2DA 4CXKA 2W5RA 5AJ9A 1KH5A 3UN5A 4LRCA 1EW9A 3NKMA 3IGYB 2GSOA 1EW2A 4LR2A 3DYCA 2W5TA 5LRNA 3DPCA 3KD8A 2G9YA 5IJQA 3BDFA 2IUCB 3SZZA 3UO0A 5IJSA 1E2SP 4KM4A 2X98A 4KJDA 3OT9A 1ELXA 1ED9A 1ALIA 4FDIA 1AJDA 4MIVA 3MK2A 1E3CP 4FDJA 2GLQA 1Y6VA 3M7VA 3NKPA 5L0KA 1ANJA 4LREA 1ALJA 1SHQA 2RH6A 4KJGA
chains in the Genus database with same CATH superfamily
1ED8A 1KHNA 1P49A 1ELZA 3ED4A 3WAVA 2ZKTA 4MHXA 3BDGA 3M8YA 5L0BA 3M8ZA 3WAXA 1N2KA 1ANIA 4UPIA 5GOVA 5GRRA 2W8DA 1KHKA 3T01A 4LRFA 4LR9A 2W5WA 2W5QA 1ZEDA 2GSUA 3BDHA 4UPHA 1KH9A 3NKNA 1N2LA 1E33P 4NWXA 5EGHA 4GTWA 4UORA 2W5VA 5KXAA 4B56A 2VQRA 5DLWA 4ZG6A 1AJCA 1E1ZP 3MK0A 1O98A 2IFYA 2W8SA 4MY4A 4LRAA 3SZYA 1KH7A 3B5QA 1Y7AA 4N7TA 1AJBA 3CMRA 4GTYA 4KAYA 5DLTA 5C66A 1EQJA 4ZGAA 3NKRA 3UNYA 5LRMA 2QZUA 1HDHA 3T00A 5DLVA 3TX0A 2GA3A 4CXUA 3WAYA 3UN2A 5LQQA 1ZEBA 1FSUA 5INHA 1ALHA 4LR8A 4GTXA 1KHJA 3NKQA 4ZG9A 3WAWA 4NWJA 2W5XA 3IDDA 3Q3QA 4LRDA 3T02A 1EI6A 2D1GA 1O99A 2ANHA 5LIAA 3MK1A 1ELYA 4CYSA 2XR9A 4LR7A 4UOOA 4CXSA 1EJJA 4QAXA 3TG0A 1AJAA 3BDGB 5L0EA 3A52A 3TWZA 1HJKA 3M8WA 1EW8A 4GTZA 3WBHA 4YR1A 5TJ3A 5EGEA 4LRBA 1ALKA 4UOPA 2IUCA 2XRGA 3NVLA 4UPLA 1SHNA 4KAVA 1ZEFA 4LQYA 1KH4A 2GSNA 2W5SA 4CYRA 3NKOA 1B8JA 3IGZB 5HRTA 1URBA 4ZG7A 4UPKA 3LXQA 3UN3A 1HQAA 1URAA 1AUKA 1KHLA 4TN0A 5K4PA 1K7HA 3E2DA 4CXKA 2W5RA 5AJ9A 1KH5A 3UN5A 4LRCA 1EW9A 3NKMA 3IGYB 2GSOA 1EW2A 4LR2A 3DYCA 2W5TA 5LRNA 3DPCA 3KD8A 2G9YA 5IJQA 3BDFA 2IUCB 3SZZA 3UO0A 5IJSA 1E2SP 4KM4A 2X98A 4KJDA 3OT9A 1ELXA 1ED9A 1ALIA 4FDIA 1AJDA 4MIVA 3MK2A 1E3CP 4FDJA 2GLQA 1Y6VA 3M7VA 3NKPA 5L0KA 1ANJA 4LREA 1ALJA 1SHQA 2RH6A 4KJGA
chains in the Genus database with same CATH topology
1ED8A 1KHNA 1P49A 1ELZA 3ED4A 3WAVA 2ZKTA 4MHXA 3BDGA 3M8YA 5L0BA 3M8ZA 3WAXA 1N2KA 1ANIA 4UPIA 5GOVA 5GRRA 2W8DA 1KHKA 3T01A 4LRFA 4LR9A 2W5WA 2W5QA 1ZEDA 2GSUA 3BDHA 4UPHA 1KH9A 3NKNA 1N2LA 1E33P 4NWXA 5EGHA 4GTWA 4UORA 2W5VA 5KXAA 4B56A 2VQRA 5DLWA 4ZG6A 1AJCA 1E1ZP 3MK0A 1O98A 2IFYA 2W8SA 4MY4A 4LRAA 3SZYA 1KH7A 3B5QA 1Y7AA 4N7TA 1AJBA 3CMRA 4GTYA 4KAYA 5DLTA 5C66A 1EQJA 4ZGAA 3NKRA 3UNYA 5LRMA 2QZUA 1HDHA 3T00A 5DLVA 3TX0A 2GA3A 4CXUA 3WAYA 3UN2A 5LQQA 1ZEBA 1FSUA 5INHA 1ALHA 4LR8A 4GTXA 1KHJA 3NKQA 4ZG9A 3WAWA 4NWJA 2W5XA 3IDDA 3Q3QA 4LRDA 3T02A 1EI6A 2D1GA 1O99A 2ANHA 5LIAA 3MK1A 1ELYA 4CYSA 2XR9A 4LR7A 4UOOA 4CXSA 1EJJA 4QAXA 3TG0A 1AJAA 3BDGB 5L0EA 3A52A 3TWZA 1HJKA 3M8WA 1EW8A 4GTZA 3WBHA 4YR1A 5TJ3A 5EGEA 4LRBA 1ALKA 4UOPA 2IUCA 2XRGA 3NVLA 4UPLA 1SHNA 4KAVA 1ZEFA 4LQYA 1KH4A 2GSNA 2W5SA 4CYRA 3NKOA 1B8JA 3IGZB 5HRTA 1URBA 4ZG7A 4UPKA 3LXQA 3UN3A 1HQAA 1URAA 1AUKA 1KHLA 4TN0A 5K4PA 1K7HA 3E2DA 4CXKA 2W5RA 5AJ9A 1KH5A 3UN5A 4LRCA 1EW9A 3NKMA 3IGYB 2GSOA 1EW2A 4LR2A 3DYCA 2W5TA 5LRNA 3DPCA 3KD8A 2G9YA 5IJQA 3BDFA 2IUCB 3SZZA 3UO0A 5IJSA 1E2SP 4KM4A 2X98A 4KJDA 3OT9A 1ELXA 1ED9A 1ALIA 4FDIA 1AJDA 4MIVA 3MK2A 1E3CP 4FDJA 2GLQA 1Y6VA 3M7VA 3NKPA 5L0KA 1ANJA 4LREA 1ALJA 1SHQA 2RH6A 4KJGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED8 A;  1KHN A;  1P49 A;  1ELZ A;  3ED4 A;  3WAV A;  2ZKT A;  4MHX A;  3BDG A;  3M8Y A;  5L0B A;  3M8Z A;  3WAX A;  1N2K A;  1ANI A;  4UPI A;  5GOV A;  5GRR A;  2W8D A;  1KHK A;  3T01 A;  4LRF A;  4LR9 A;  2W5W A;  2W5Q A;  1ZED A;  2GSU A;  3BDH A;  4UPH A;  1KH9 A;  3NKN A;  1N2L A;  1E33 P;  4NWX A;  5EGH A;  4GTW A;  4UOR A;  2W5V A;  5KXA A;  4B56 A;  2VQR A;  5DLW A;  4ZG6 A;  1AJC A;  1E1Z P;  3MK0 A;  1O98 A;  2IFY A;  2W8S A;  4MY4 A;  4LRA A;  3SZY A;  1KH7 A;  3B5Q A;  1Y7A A;  4N7T A;  1AJB A;  3CMR A;  4GTY A;  4KAY A;  5DLT A;  5C66 A;  1EQJ A;  4ZGA A;  3NKR A;  3UNY A;  5LRM A;  2QZU A;  1HDH A;  3T00 A;  5DLV A;  3TX0 A;  2GA3 A;  4CXU A;  3WAY A;  3UN2 A;  5LQQ A;  1ZEB A;  1FSU A;  5INH A;  1ALH A;  4LR8 A;  4GTX A;  1KHJ A;  3NKQ A;  4ZG9 A;  3WAW A;  4NWJ A;  2W5X A;  3IDD A;  3Q3Q A;  4LRD A;  3T02 A;  1EI6 A;  2D1G A;  1O99 A;  2ANH A;  5LIA A;  3MK1 A;  1ELY A;  4CYS A;  2XR9 A;  4LR7 A;  4UOO A;  4CXS A;  1EJJ A;  4QAX A;  3TG0 A;  1AJA A;  3BDG B;  5L0E A;  3A52 A;  3TWZ A;  1HJK A;  3M8W A;  1EW8 A;  4GTZ A;  3WBH A;  4YR1 A;  5TJ3 A;  5EGE A;  4LRB A;  1ALK A;  4UOP A;  2IUC A;  2XRG A;  3NVL A;  4UPL A;  1SHN A;  4KAV A;  1ZEF A;  4LQY A;  1KH4 A;  2GSN A;  2W5S A;  4CYR A;  3NKO A;  1B8J A;  3IGZ B;  5HRT A;  1URB A;  4ZG7 A;  4UPK A;  3LXQ A;  3UN3 A;  1HQA A;  1URA A;  1AUK A;  1KHL A;  4TN0 A;  5K4P A;  1K7H A;  3E2D A;  4CXK A;  2W5R A;  5AJ9 A;  1KH5 A;  3UN5 A;  4LRC A;  1EW9 A;  3NKM A;  3IGY B;  2GSO A;  1EW2 A;  4LR2 A;  3DYC A;  2W5T A;  5LRN A;  3DPC A;  3KD8 A;  2G9Y A;  5IJQ A;  3BDF A;  2IUC B;  3SZZ A;  3UO0 A;  5IJS A;  1E2S P;  4KM4 A;  2X98 A;  4KJD A;  3OT9 A;  1ELX A;  1ED9 A;  1ALI A;  4FDI A;  1AJD A;  4MIV A;  3MK2 A;  1E3C P;  4FDJ A;  2GLQ A;  1Y6V A;  3M7V A;  3NKP A;  5L0K A;  1ANJ A;  4LRE A;  1ALJ A;  1SHQ A;  2RH6 A;  4KJG A; 
#chains in the Genus database with same CATH topology
 1ED8 A;  1KHN A;  1P49 A;  1ELZ A;  3ED4 A;  3WAV A;  2ZKT A;  4MHX A;  3BDG A;  3M8Y A;  5L0B A;  3M8Z A;  3WAX A;  1N2K A;  1ANI A;  4UPI A;  5GOV A;  5GRR A;  2W8D A;  1KHK A;  3T01 A;  4LRF A;  4LR9 A;  2W5W A;  2W5Q A;  1ZED A;  2GSU A;  3BDH A;  4UPH A;  1KH9 A;  3NKN A;  1N2L A;  1E33 P;  4NWX A;  5EGH A;  4GTW A;  4UOR A;  2W5V A;  5KXA A;  4B56 A;  2VQR A;  5DLW A;  4ZG6 A;  1AJC A;  1E1Z P;  3MK0 A;  1O98 A;  2IFY A;  2W8S A;  4MY4 A;  4LRA A;  3SZY A;  1KH7 A;  3B5Q A;  1Y7A A;  4N7T A;  1AJB A;  3CMR A;  4GTY A;  4KAY A;  5DLT A;  5C66 A;  1EQJ A;  4ZGA A;  3NKR A;  3UNY A;  5LRM A;  2QZU A;  1HDH A;  3T00 A;  5DLV A;  3TX0 A;  2GA3 A;  4CXU A;  3WAY A;  3UN2 A;  5LQQ A;  1ZEB A;  1FSU A;  5INH A;  1ALH A;  4LR8 A;  4GTX A;  1KHJ A;  3NKQ A;  4ZG9 A;  3WAW A;  4NWJ A;  2W5X A;  3IDD A;  3Q3Q A;  4LRD A;  3T02 A;  1EI6 A;  2D1G A;  1O99 A;  2ANH A;  5LIA A;  3MK1 A;  1ELY A;  4CYS A;  2XR9 A;  4LR7 A;  4UOO A;  4CXS A;  1EJJ A;  4QAX A;  3TG0 A;  1AJA A;  3BDG B;  5L0E A;  3A52 A;  3TWZ A;  1HJK A;  3M8W A;  1EW8 A;  4GTZ A;  3WBH A;  4YR1 A;  5TJ3 A;  5EGE A;  4LRB A;  1ALK A;  4UOP A;  2IUC A;  2XRG A;  3NVL A;  4UPL A;  1SHN A;  4KAV A;  1ZEF A;  4LQY A;  1KH4 A;  2GSN A;  2W5S A;  4CYR A;  3NKO A;  1B8J A;  3IGZ B;  5HRT A;  1URB A;  4ZG7 A;  4UPK A;  3LXQ A;  3UN3 A;  1HQA A;  1URA A;  1AUK A;  1KHL A;  4TN0 A;  5K4P A;  1K7H A;  3E2D A;  4CXK A;  2W5R A;  5AJ9 A;  1KH5 A;  3UN5 A;  4LRC A;  1EW9 A;  3NKM A;  3IGY B;  2GSO A;  1EW2 A;  4LR2 A;  3DYC A;  2W5T A;  5LRN A;  3DPC A;  3KD8 A;  2G9Y A;  5IJQ A;  3BDF A;  2IUC B;  3SZZ A;  3UO0 A;  5IJS A;  1E2S P;  4KM4 A;  2X98 A;  4KJD A;  3OT9 A;  1ELX A;  1ED9 A;  1ALI A;  4FDI A;  1AJD A;  4MIV A;  3MK2 A;  1E3C P;  4FDJ A;  2GLQ A;  1Y6V A;  3M7V A;  3NKP A;  5L0K A;  1ANJ A;  4LRE A;  1ALJ A;  1SHQ A;  2RH6 A;  4KJG A; 
#chains in the Genus database with same CATH homology
 1ED8 A;  1KHN A;  1P49 A;  1ELZ A;  3ED4 A;  3WAV A;  2ZKT A;  4MHX A;  3BDG A;  3M8Y A;  5L0B A;  3M8Z A;  3WAX A;  1N2K A;  1ANI A;  4UPI A;  5GOV A;  5GRR A;  2W8D A;  1KHK A;  3T01 A;  4LRF A;  4LR9 A;  2W5W A;  2W5Q A;  1ZED A;  2GSU A;  3BDH A;  4UPH A;  1KH9 A;  3NKN A;  1N2L A;  1E33 P;  4NWX A;  5EGH A;  4GTW A;  4UOR A;  2W5V A;  5KXA A;  4B56 A;  2VQR A;  5DLW A;  4ZG6 A;  1AJC A;  1E1Z P;  3MK0 A;  1O98 A;  2IFY A;  2W8S A;  4MY4 A;  4LRA A;  3SZY A;  1KH7 A;  3B5Q A;  1Y7A A;  4N7T A;  1AJB A;  3CMR A;  4GTY A;  4KAY A;  5DLT A;  5C66 A;  1EQJ A;  4ZGA A;  3NKR A;  3UNY A;  5LRM A;  2QZU A;  1HDH A;  3T00 A;  5DLV A;  3TX0 A;  2GA3 A;  4CXU A;  3WAY A;  3UN2 A;  5LQQ A;  1ZEB A;  1FSU A;  5INH A;  1ALH A;  4LR8 A;  4GTX A;  1KHJ A;  3NKQ A;  4ZG9 A;  3WAW A;  4NWJ A;  2W5X A;  3IDD A;  3Q3Q A;  4LRD A;  3T02 A;  1EI6 A;  2D1G A;  1O99 A;  2ANH A;  5LIA A;  3MK1 A;  1ELY A;  4CYS A;  2XR9 A;  4LR7 A;  4UOO A;  4CXS A;  1EJJ A;  4QAX A;  3TG0 A;  1AJA A;  3BDG B;  5L0E A;  3A52 A;  3TWZ A;  1HJK A;  3M8W A;  1EW8 A;  4GTZ A;  3WBH A;  4YR1 A;  5TJ3 A;  5EGE A;  4LRB A;  1ALK A;  4UOP A;  2IUC A;  2XRG A;  3NVL A;  4UPL A;  1SHN A;  4KAV A;  1ZEF A;  4LQY A;  1KH4 A;  2GSN A;  2W5S A;  4CYR A;  3NKO A;  1B8J A;  3IGZ B;  5HRT A;  1URB A;  4ZG7 A;  4UPK A;  3LXQ A;  3UN3 A;  1HQA A;  1URA A;  1AUK A;  1KHL A;  4TN0 A;  5K4P A;  1K7H A;  3E2D A;  4CXK A;  2W5R A;  5AJ9 A;  1KH5 A;  3UN5 A;  4LRC A;  1EW9 A;  3NKM A;  3IGY B;  2GSO A;  1EW2 A;  4LR2 A;  3DYC A;  2W5T A;  5LRN A;  3DPC A;  3KD8 A;  2G9Y A;  5IJQ A;  3BDF A;  2IUC B;  3SZZ A;  3UO0 A;  5IJS A;  1E2S P;  4KM4 A;  2X98 A;  4KJD A;  3OT9 A;  1ELX A;  1ED9 A;  1ALI A;  4FDI A;  1AJD A;  4MIV A;  3MK2 A;  1E3C P;  4FDJ A;  2GLQ A;  1Y6V A;  3M7V A;  3NKP A;  5L0K A;  1ANJ A;  4LRE A;  1ALJ A;  1SHQ A;  2RH6 A;  4KJG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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