3BDGA

Crystal structure of wild-type/t155v mixed dimer of e. coli alkaline phosphatase
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
448
structure length
434
Chain Sequence
PEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDAVPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title The Active-Site Trimetallic Cluster of Alkaline Phosphatase is Lost Upon Isosteric Mutation at the Mg2+-Coordinating Residue Threonine-155
rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 434
sequence length 448
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2007-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3bdgA00
4UPKA 5LRMA 2ZKTA 3T01A 4LR7A 5DLWA 1ANIA 2IUCB 3NKQA 4CXSA 3MK0A 1URBA 1ED9A 1E2SP 3TWZA 2XRGA 1N2KA 3NKNA 5GRRA 1O99A 1KHJA 4CXUA 1HQAA 5EGEA 5DLVA 5DLTA 5IJQA 2W5RA 2GSOA 2W5SA 3DPCA 1K7HA 4FDIA 3UO0A 4CXKA 3TX0A 1AJBA 1AJDA 1EQJA 2W8DA 1AJAA 4LRCA 4MY4A 4KM4A 3UN5A 2X98A 3BDGB 2IUCA 4LREA 5TJ3A 3WAXA 4ZG6A 2G9YA 2VQRA 2GLQA 3UN2A 3NVLA 2D1GA 4UORA 4QAXA 1ANJA 1B8JA 2ANHA 4MIVA 5LIAA 1ELZA 5C66A 4CYRA 1ZEFA 3T00A 5AJ9A 3M8YA 4LRBA 1URAA 1Y6VA 5KXAA 4UOOA 4UPIA 3WAYA 4MHXA 4GTZA 5L0BA 4YR1A 4LR2A 2GSNA 4GTXA 2W5QA 1EI6A 1EW9A 1AUKA 3M7VA 5EGHA 3BDGA 1SHQA 5GOVA 3IGZB 4FDJA 1O98A 3WBHA 3CMRA 3M8ZA 4LRAA 3WAVA 4GTWA 3Q3QA 4LR9A 3B5QA 2GA3A 4KAVA 3SZYA 1ALKA 3KD8A 1EW8A 2QZUA 3BDFA 1ED8A 3ED4A 3IGYB 3NKPA 1KH9A 3LXQA 3A52A 1ELYA 5K4PA 4CYSA 3UN3A 5IJSA 2W8SA 3OT9A 5L0EA 1N2LA 5LRNA 4KAYA 1KH5A 4UPLA 1Y7AA 4LQYA 4NWJA 3DYCA 3SZZA 2W5WA 3T02A 3M8WA 1KH4A 4TN0A 4ZG7A 3MK2A 1P49A 3NKMA 4LR8A 3WAWA 5L0KA 5HRTA 2XR9A 4NWXA 3BDHA 3UNYA 3NKOA 1ZEDA 3E2DA 3IDDA 1ZEBA 3NKRA 3TG0A 1KHNA 2W5VA 4ZGAA 1AJCA 1SHNA 4KJGA 4GTYA 4UOPA 1ALIA 4LRFA 4ZG9A 1KHLA 2GSUA 4UPHA 5LQQA 2W5TA 2RH6A 1EW2A 1ALHA 4LRDA 1ALJA 2W5XA 4KJDA 1KH7A 1HDHA 1FSUA 5INHA 3MK1A 1KHKA 4B56A 1HJKA 1E33P 1E1ZP 1EJJA 2IFYA 1E3CP 1ELXA 4N7TA
chains in the Genus database with same CATH superfamily
4UPKA 5LRMA 2ZKTA 3T01A 4LR7A 5DLWA 1ANIA 2IUCB 3NKQA 4CXSA 3MK0A 1URBA 1ED9A 1E2SP 3TWZA 2XRGA 1N2KA 3NKNA 5GRRA 1O99A 1KHJA 4CXUA 1HQAA 5EGEA 5DLVA 5DLTA 5IJQA 2W5RA 2GSOA 2W5SA 3DPCA 1K7HA 4FDIA 3UO0A 4CXKA 3TX0A 1AJBA 1AJDA 1EQJA 2W8DA 1AJAA 4LRCA 4MY4A 4KM4A 3UN5A 2X98A 3BDGB 2IUCA 4LREA 5TJ3A 3WAXA 4ZG6A 2G9YA 2VQRA 2GLQA 3UN2A 3NVLA 2D1GA 4UORA 4QAXA 1ANJA 1B8JA 2ANHA 4MIVA 5LIAA 1ELZA 5C66A 4CYRA 1ZEFA 3T00A 5AJ9A 3M8YA 4LRBA 1URAA 1Y6VA 5KXAA 4UOOA 4UPIA 3WAYA 4MHXA 4GTZA 5L0BA 4YR1A 4LR2A 2GSNA 4GTXA 2W5QA 1EI6A 1EW9A 1AUKA 3M7VA 5EGHA 3BDGA 1SHQA 5GOVA 3IGZB 4FDJA 1O98A 3WBHA 3CMRA 3M8ZA 4LRAA 3WAVA 4GTWA 3Q3QA 4LR9A 3B5QA 2GA3A 4KAVA 3SZYA 1ALKA 3KD8A 1EW8A 2QZUA 3BDFA 1ED8A 3ED4A 3IGYB 3NKPA 1KH9A 3LXQA 3A52A 1ELYA 5K4PA 4CYSA 3UN3A 5IJSA 2W8SA 3OT9A 5L0EA 1N2LA 5LRNA 4KAYA 1KH5A 4UPLA 1Y7AA 4LQYA 4NWJA 3DYCA 3SZZA 2W5WA 3T02A 3M8WA 1KH4A 4TN0A 4ZG7A 3MK2A 1P49A 3NKMA 4LR8A 3WAWA 5L0KA 5HRTA 2XR9A 4NWXA 3BDHA 3UNYA 3NKOA 1ZEDA 3E2DA 3IDDA 1ZEBA 3NKRA 3TG0A 1KHNA 2W5VA 4ZGAA 1AJCA 1SHNA 4KJGA 4GTYA 4UOPA 1ALIA 4LRFA 4ZG9A 1KHLA 2GSUA 4UPHA 5LQQA 2W5TA 2RH6A 1EW2A 1ALHA 4LRDA 1ALJA 2W5XA 4KJDA 1KH7A 1HDHA 1FSUA 5INHA 3MK1A 1KHKA 4B56A 1HJKA 1E33P 1E1ZP 1EJJA 2IFYA 1E3CP 1ELXA 4N7TA
chains in the Genus database with same CATH topology
4UPKA 5LRMA 2ZKTA 3T01A 4LR7A 5DLWA 1ANIA 2IUCB 3NKQA 4CXSA 3MK0A 1URBA 1ED9A 1E2SP 3TWZA 2XRGA 1N2KA 3NKNA 5GRRA 1O99A 1KHJA 4CXUA 1HQAA 5EGEA 5DLVA 5DLTA 5IJQA 2W5RA 2GSOA 2W5SA 3DPCA 1K7HA 4FDIA 3UO0A 4CXKA 3TX0A 1AJBA 1AJDA 1EQJA 2W8DA 1AJAA 4LRCA 4MY4A 4KM4A 3UN5A 2X98A 3BDGB 2IUCA 4LREA 5TJ3A 3WAXA 4ZG6A 2G9YA 2VQRA 2GLQA 3UN2A 3NVLA 2D1GA 4UORA 4QAXA 1ANJA 1B8JA 2ANHA 4MIVA 5LIAA 1ELZA 5C66A 4CYRA 1ZEFA 3T00A 5AJ9A 3M8YA 4LRBA 1URAA 1Y6VA 5KXAA 4UOOA 4UPIA 3WAYA 4MHXA 4GTZA 5L0BA 4YR1A 4LR2A 2GSNA 4GTXA 2W5QA 1EI6A 1EW9A 1AUKA 3M7VA 5EGHA 3BDGA 1SHQA 5GOVA 3IGZB 4FDJA 1O98A 3WBHA 3CMRA 3M8ZA 4LRAA 3WAVA 4GTWA 3Q3QA 4LR9A 3B5QA 2GA3A 4KAVA 3SZYA 1ALKA 3KD8A 1EW8A 2QZUA 3BDFA 1ED8A 3ED4A 3IGYB 3NKPA 1KH9A 3LXQA 3A52A 1ELYA 5K4PA 4CYSA 3UN3A 5IJSA 2W8SA 3OT9A 5L0EA 1N2LA 5LRNA 4KAYA 1KH5A 4UPLA 1Y7AA 4LQYA 4NWJA 3DYCA 3SZZA 2W5WA 3T02A 3M8WA 1KH4A 4TN0A 4ZG7A 3MK2A 1P49A 3NKMA 4LR8A 3WAWA 5L0KA 5HRTA 2XR9A 4NWXA 3BDHA 3UNYA 3NKOA 1ZEDA 3E2DA 3IDDA 1ZEBA 3NKRA 3TG0A 1KHNA 2W5VA 4ZGAA 1AJCA 1SHNA 4KJGA 4GTYA 4UOPA 1ALIA 4LRFA 4ZG9A 1KHLA 2GSUA 4UPHA 5LQQA 2W5TA 2RH6A 1EW2A 1ALHA 4LRDA 1ALJA 2W5XA 4KJDA 1KH7A 1HDHA 1FSUA 5INHA 3MK1A 1KHKA 4B56A 1HJKA 1E33P 1E1ZP 1EJJA 2IFYA 1E3CP 1ELXA 4N7TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPK A;  5LRM A;  2ZKT A;  3T01 A;  4LR7 A;  5DLW A;  1ANI A;  2IUC B;  3NKQ A;  4CXS A;  3MK0 A;  1URB A;  1ED9 A;  1E2S P;  3TWZ A;  2XRG A;  1N2K A;  3NKN A;  5GRR A;  1O99 A;  1KHJ A;  4CXU A;  1HQA A;  5EGE A;  5DLV A;  5DLT A;  5IJQ A;  2W5R A;  2GSO A;  2W5S A;  3DPC A;  1K7H A;  4FDI A;  3UO0 A;  4CXK A;  3TX0 A;  1AJB A;  1AJD A;  1EQJ A;  2W8D A;  1AJA A;  4LRC A;  4MY4 A;  4KM4 A;  3UN5 A;  2X98 A;  3BDG B;  2IUC A;  4LRE A;  5TJ3 A;  3WAX A;  4ZG6 A;  2G9Y A;  2VQR A;  2GLQ A;  3UN2 A;  3NVL A;  2D1G A;  4UOR A;  4QAX A;  1ANJ A;  1B8J A;  2ANH A;  4MIV A;  5LIA A;  1ELZ A;  5C66 A;  4CYR A;  1ZEF A;  3T00 A;  5AJ9 A;  3M8Y A;  4LRB A;  1URA A;  1Y6V A;  5KXA A;  4UOO A;  4UPI A;  3WAY A;  4MHX A;  4GTZ A;  5L0B A;  4YR1 A;  4LR2 A;  2GSN A;  4GTX A;  2W5Q A;  1EI6 A;  1EW9 A;  1AUK A;  3M7V A;  5EGH A;  3BDG A;  1SHQ A;  5GOV A;  3IGZ B;  4FDJ A;  1O98 A;  3WBH A;  3CMR A;  3M8Z A;  4LRA A;  3WAV A;  4GTW A;  3Q3Q A;  4LR9 A;  3B5Q A;  2GA3 A;  4KAV A;  3SZY A;  1ALK A;  3KD8 A;  1EW8 A;  2QZU A;  3BDF A;  1ED8 A;  3ED4 A;  3IGY B;  3NKP A;  1KH9 A;  3LXQ A;  3A52 A;  1ELY A;  5K4P A;  4CYS A;  3UN3 A;  5IJS A;  2W8S A;  3OT9 A;  5L0E A;  1N2L A;  5LRN A;  4KAY A;  1KH5 A;  4UPL A;  1Y7A A;  4LQY A;  4NWJ A;  3DYC A;  3SZZ A;  2W5W A;  3T02 A;  3M8W A;  1KH4 A;  4TN0 A;  4ZG7 A;  3MK2 A;  1P49 A;  3NKM A;  4LR8 A;  3WAW A;  5L0K A;  5HRT A;  2XR9 A;  4NWX A;  3BDH A;  3UNY A;  3NKO A;  1ZED A;  3E2D A;  3IDD A;  1ZEB A;  3NKR A;  3TG0 A;  1KHN A;  2W5V A;  4ZGA A;  1AJC A;  1SHN A;  4KJG A;  4GTY A;  4UOP A;  1ALI A;  4LRF A;  4ZG9 A;  1KHL A;  2GSU A;  4UPH A;  5LQQ A;  2W5T A;  2RH6 A;  1EW2 A;  1ALH A;  4LRD A;  1ALJ A;  2W5X A;  4KJD A;  1KH7 A;  1HDH A;  1FSU A;  5INH A;  3MK1 A;  1KHK A;  4B56 A;  1HJK A;  1E33 P;  1E1Z P;  1EJJ A;  2IFY A;  1E3C P;  1ELX A;  4N7T A; 
#chains in the Genus database with same CATH topology
 4UPK A;  5LRM A;  2ZKT A;  3T01 A;  4LR7 A;  5DLW A;  1ANI A;  2IUC B;  3NKQ A;  4CXS A;  3MK0 A;  1URB A;  1ED9 A;  1E2S P;  3TWZ A;  2XRG A;  1N2K A;  3NKN A;  5GRR A;  1O99 A;  1KHJ A;  4CXU A;  1HQA A;  5EGE A;  5DLV A;  5DLT A;  5IJQ A;  2W5R A;  2GSO A;  2W5S A;  3DPC A;  1K7H A;  4FDI A;  3UO0 A;  4CXK A;  3TX0 A;  1AJB A;  1AJD A;  1EQJ A;  2W8D A;  1AJA A;  4LRC A;  4MY4 A;  4KM4 A;  3UN5 A;  2X98 A;  3BDG B;  2IUC A;  4LRE A;  5TJ3 A;  3WAX A;  4ZG6 A;  2G9Y A;  2VQR A;  2GLQ A;  3UN2 A;  3NVL A;  2D1G A;  4UOR A;  4QAX A;  1ANJ A;  1B8J A;  2ANH A;  4MIV A;  5LIA A;  1ELZ A;  5C66 A;  4CYR A;  1ZEF A;  3T00 A;  5AJ9 A;  3M8Y A;  4LRB A;  1URA A;  1Y6V A;  5KXA A;  4UOO A;  4UPI A;  3WAY A;  4MHX A;  4GTZ A;  5L0B A;  4YR1 A;  4LR2 A;  2GSN A;  4GTX A;  2W5Q A;  1EI6 A;  1EW9 A;  1AUK A;  3M7V A;  5EGH A;  3BDG A;  1SHQ A;  5GOV A;  3IGZ B;  4FDJ A;  1O98 A;  3WBH A;  3CMR A;  3M8Z A;  4LRA A;  3WAV A;  4GTW A;  3Q3Q A;  4LR9 A;  3B5Q A;  2GA3 A;  4KAV A;  3SZY A;  1ALK A;  3KD8 A;  1EW8 A;  2QZU A;  3BDF A;  1ED8 A;  3ED4 A;  3IGY B;  3NKP A;  1KH9 A;  3LXQ A;  3A52 A;  1ELY A;  5K4P A;  4CYS A;  3UN3 A;  5IJS A;  2W8S A;  3OT9 A;  5L0E A;  1N2L A;  5LRN A;  4KAY A;  1KH5 A;  4UPL A;  1Y7A A;  4LQY A;  4NWJ A;  3DYC A;  3SZZ A;  2W5W A;  3T02 A;  3M8W A;  1KH4 A;  4TN0 A;  4ZG7 A;  3MK2 A;  1P49 A;  3NKM A;  4LR8 A;  3WAW A;  5L0K A;  5HRT A;  2XR9 A;  4NWX A;  3BDH A;  3UNY A;  3NKO A;  1ZED A;  3E2D A;  3IDD A;  1ZEB A;  3NKR A;  3TG0 A;  1KHN A;  2W5V A;  4ZGA A;  1AJC A;  1SHN A;  4KJG A;  4GTY A;  4UOP A;  1ALI A;  4LRF A;  4ZG9 A;  1KHL A;  2GSU A;  4UPH A;  5LQQ A;  2W5T A;  2RH6 A;  1EW2 A;  1ALH A;  4LRD A;  1ALJ A;  2W5X A;  4KJD A;  1KH7 A;  1HDH A;  1FSU A;  5INH A;  3MK1 A;  1KHK A;  4B56 A;  1HJK A;  1E33 P;  1E1Z P;  1EJJ A;  2IFY A;  1E3C P;  1ELX A;  4N7T A; 
#chains in the Genus database with same CATH homology
 4UPK A;  5LRM A;  2ZKT A;  3T01 A;  4LR7 A;  5DLW A;  1ANI A;  2IUC B;  3NKQ A;  4CXS A;  3MK0 A;  1URB A;  1ED9 A;  1E2S P;  3TWZ A;  2XRG A;  1N2K A;  3NKN A;  5GRR A;  1O99 A;  1KHJ A;  4CXU A;  1HQA A;  5EGE A;  5DLV A;  5DLT A;  5IJQ A;  2W5R A;  2GSO A;  2W5S A;  3DPC A;  1K7H A;  4FDI A;  3UO0 A;  4CXK A;  3TX0 A;  1AJB A;  1AJD A;  1EQJ A;  2W8D A;  1AJA A;  4LRC A;  4MY4 A;  4KM4 A;  3UN5 A;  2X98 A;  3BDG B;  2IUC A;  4LRE A;  5TJ3 A;  3WAX A;  4ZG6 A;  2G9Y A;  2VQR A;  2GLQ A;  3UN2 A;  3NVL A;  2D1G A;  4UOR A;  4QAX A;  1ANJ A;  1B8J A;  2ANH A;  4MIV A;  5LIA A;  1ELZ A;  5C66 A;  4CYR A;  1ZEF A;  3T00 A;  5AJ9 A;  3M8Y A;  4LRB A;  1URA A;  1Y6V A;  5KXA A;  4UOO A;  4UPI A;  3WAY A;  4MHX A;  4GTZ A;  5L0B A;  4YR1 A;  4LR2 A;  2GSN A;  4GTX A;  2W5Q A;  1EI6 A;  1EW9 A;  1AUK A;  3M7V A;  5EGH A;  3BDG A;  1SHQ A;  5GOV A;  3IGZ B;  4FDJ A;  1O98 A;  3WBH A;  3CMR A;  3M8Z A;  4LRA A;  3WAV A;  4GTW A;  3Q3Q A;  4LR9 A;  3B5Q A;  2GA3 A;  4KAV A;  3SZY A;  1ALK A;  3KD8 A;  1EW8 A;  2QZU A;  3BDF A;  1ED8 A;  3ED4 A;  3IGY B;  3NKP A;  1KH9 A;  3LXQ A;  3A52 A;  1ELY A;  5K4P A;  4CYS A;  3UN3 A;  5IJS A;  2W8S A;  3OT9 A;  5L0E A;  1N2L A;  5LRN A;  4KAY A;  1KH5 A;  4UPL A;  1Y7A A;  4LQY A;  4NWJ A;  3DYC A;  3SZZ A;  2W5W A;  3T02 A;  3M8W A;  1KH4 A;  4TN0 A;  4ZG7 A;  3MK2 A;  1P49 A;  3NKM A;  4LR8 A;  3WAW A;  5L0K A;  5HRT A;  2XR9 A;  4NWX A;  3BDH A;  3UNY A;  3NKO A;  1ZED A;  3E2D A;  3IDD A;  1ZEB A;  3NKR A;  3TG0 A;  1KHN A;  2W5V A;  4ZGA A;  1AJC A;  1SHN A;  4KJG A;  4GTY A;  4UOP A;  1ALI A;  4LRF A;  4ZG9 A;  1KHL A;  2GSU A;  4UPH A;  5LQQ A;  2W5T A;  2RH6 A;  1EW2 A;  1ALH A;  4LRD A;  1ALJ A;  2W5X A;  4KJD A;  1KH7 A;  1HDH A;  1FSU A;  5INH A;  3MK1 A;  1KHK A;  4B56 A;  1HJK A;  1E33 P;  1E1Z P;  1EJJ A;  2IFY A;  1E3C P;  1ELX A;  4N7T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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