1KH4A

E. coli alkaline phosphatase mutant (d330n) in complex with phosphate
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 154
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh4A00
2XR9A 1ELYA 1EJJA 5IJQA 1O98A 3M8ZA 5AJ9A 4LRBA 1HQAA 2D1GA 4ZG7A 1KH7A 3M8WA 3OT9A 4QAXA 4UPIA 3WAYA 5C66A 3IGZB 1N2KA 4GTXA 3NKOA 4TN0A 4ZGAA 2W5XA 4UPLA 1ELXA 3NKPA 3NKMA 4LR9A 4UOOA 4B56A 3SZYA 3LXQA 1E3CP 5LRNA 1E33P 2X98A 1AUKA 3BDGB 4ZG9A 1AJCA 3IDDA 4LR7A 5EGHA 2GSOA 3TG0A 3UO0A 4CYSA 1SHQA 2IUCA 4KM4A 4GTWA 1KH9A 2W5QA 4NWXA 1EW2A 1B8JA 5K4PA 3T00A 5DLWA 1ALIA 4CXKA 3M8YA 4LRDA 2W5RA 2VQRA 1AJAA 1URAA 1ED9A 4UPKA 2IFYA 4CXUA 5LIAA 2W5VA 1ED8A 1EW9A 3T01A 3BDHA 3UNYA 3WAWA 1ZEDA 3DYCA 3MK1A 1Y7AA 4LREA 1ANJA 1KH5A 1ALHA 3M7VA 3CMRA 1ZEFA 4MHXA 5L0EA 1ALJA 1O99A 4YR1A 3TX0A 2W8DA 2QZUA 4LR2A 4CXSA 3BDFA 3IGYB 5LQQA 2G9YA 1E2SP 3MK0A 1EQJA 4LRFA 5LRMA 2IUCB 3WBHA 1KH4A 2GSNA 4FDIA 3SZZA 2GA3A 4KAYA 1ELZA 5DLTA 3T02A 3UN5A 1KHJA 1ANIA 3DPCA 4LQYA 2W5SA 1SHNA 5HRTA 1FSUA 2RH6A 3BDGA 3UN3A 4GTZA 2W5WA 1HJKA 5L0KA 3A52A 1EI6A 1AJBA 1P49A 1Y6VA 4KAVA 5GOVA 1AJDA 5IJSA 4KJGA 1KHNA 1ALKA 1N2LA 4LRAA 5EGEA 2W5TA 4MY4A 3Q3QA 3MK2A 1HDHA 5KXAA 3NKRA 1EW8A 3B5QA 4ZG6A 1ZEBA 2W8SA 4NWJA 3NVLA 5GRRA 4GTYA 3WAXA 1URBA 2ANHA 4UOPA 4UORA 4CYRA 3NKQA 3WAVA 1K7HA 4FDJA 1E1ZP 4UPHA 4LRCA 5DLVA 4KJDA 2GLQA 4MIVA 3TWZA 5INHA 3ED4A 5TJ3A 3UN2A 2ZKTA 4LR8A 1KHLA 3KD8A 4N7TA 1KHKA 3E2DA 2XRGA 5L0BA 3NKNA 2GSUA
chains in the Genus database with same CATH superfamily
2XR9A 1ELYA 1EJJA 5IJQA 1O98A 3M8ZA 5AJ9A 4LRBA 1HQAA 2D1GA 4ZG7A 1KH7A 3M8WA 3OT9A 4QAXA 4UPIA 3WAYA 5C66A 3IGZB 1N2KA 4GTXA 3NKOA 4TN0A 4ZGAA 2W5XA 4UPLA 1ELXA 3NKPA 3NKMA 4LR9A 4UOOA 4B56A 3SZYA 3LXQA 1E3CP 5LRNA 1E33P 2X98A 1AUKA 3BDGB 4ZG9A 1AJCA 3IDDA 4LR7A 5EGHA 2GSOA 3TG0A 3UO0A 4CYSA 1SHQA 2IUCA 4KM4A 4GTWA 1KH9A 2W5QA 4NWXA 1EW2A 1B8JA 5K4PA 3T00A 5DLWA 1ALIA 4CXKA 3M8YA 4LRDA 2W5RA 2VQRA 1AJAA 1URAA 1ED9A 4UPKA 2IFYA 4CXUA 5LIAA 2W5VA 1ED8A 1EW9A 3T01A 3BDHA 3UNYA 3WAWA 1ZEDA 3DYCA 3MK1A 1Y7AA 4LREA 1ANJA 1KH5A 1ALHA 3M7VA 3CMRA 1ZEFA 4MHXA 5L0EA 1ALJA 1O99A 4YR1A 3TX0A 2W8DA 2QZUA 4LR2A 4CXSA 3BDFA 3IGYB 5LQQA 2G9YA 1E2SP 3MK0A 1EQJA 4LRFA 5LRMA 2IUCB 3WBHA 1KH4A 2GSNA 4FDIA 3SZZA 2GA3A 4KAYA 1ELZA 5DLTA 3T02A 3UN5A 1KHJA 1ANIA 3DPCA 4LQYA 2W5SA 1SHNA 5HRTA 1FSUA 2RH6A 3BDGA 3UN3A 4GTZA 2W5WA 1HJKA 5L0KA 3A52A 1EI6A 1AJBA 1P49A 1Y6VA 4KAVA 5GOVA 1AJDA 5IJSA 4KJGA 1KHNA 1ALKA 1N2LA 4LRAA 5EGEA 2W5TA 4MY4A 3Q3QA 3MK2A 1HDHA 5KXAA 3NKRA 1EW8A 3B5QA 4ZG6A 1ZEBA 2W8SA 4NWJA 3NVLA 5GRRA 4GTYA 3WAXA 1URBA 2ANHA 4UOPA 4UORA 4CYRA 3NKQA 3WAVA 1K7HA 4FDJA 1E1ZP 4UPHA 4LRCA 5DLVA 4KJDA 2GLQA 4MIVA 3TWZA 5INHA 3ED4A 5TJ3A 3UN2A 2ZKTA 4LR8A 1KHLA 3KD8A 4N7TA 1KHKA 3E2DA 2XRGA 5L0BA 3NKNA 2GSUA
chains in the Genus database with same CATH topology
2XR9A 1ELYA 1EJJA 5IJQA 1O98A 3M8ZA 5AJ9A 4LRBA 1HQAA 2D1GA 4ZG7A 1KH7A 3M8WA 3OT9A 4QAXA 4UPIA 3WAYA 5C66A 3IGZB 1N2KA 4GTXA 3NKOA 4TN0A 4ZGAA 2W5XA 4UPLA 1ELXA 3NKPA 3NKMA 4LR9A 4UOOA 4B56A 3SZYA 3LXQA 1E3CP 5LRNA 1E33P 2X98A 1AUKA 3BDGB 4ZG9A 1AJCA 3IDDA 4LR7A 5EGHA 2GSOA 3TG0A 3UO0A 4CYSA 1SHQA 2IUCA 4KM4A 4GTWA 1KH9A 2W5QA 4NWXA 1EW2A 1B8JA 5K4PA 3T00A 5DLWA 1ALIA 4CXKA 3M8YA 4LRDA 2W5RA 2VQRA 1AJAA 1URAA 1ED9A 4UPKA 2IFYA 4CXUA 5LIAA 2W5VA 1ED8A 1EW9A 3T01A 3BDHA 3UNYA 3WAWA 1ZEDA 3DYCA 3MK1A 1Y7AA 4LREA 1ANJA 1KH5A 1ALHA 3M7VA 3CMRA 1ZEFA 4MHXA 5L0EA 1ALJA 1O99A 4YR1A 3TX0A 2W8DA 2QZUA 4LR2A 4CXSA 3BDFA 3IGYB 5LQQA 2G9YA 1E2SP 3MK0A 1EQJA 4LRFA 5LRMA 2IUCB 3WBHA 1KH4A 2GSNA 4FDIA 3SZZA 2GA3A 4KAYA 1ELZA 5DLTA 3T02A 3UN5A 1KHJA 1ANIA 3DPCA 4LQYA 2W5SA 1SHNA 5HRTA 1FSUA 2RH6A 3BDGA 3UN3A 4GTZA 2W5WA 1HJKA 5L0KA 3A52A 1EI6A 1AJBA 1P49A 1Y6VA 4KAVA 5GOVA 1AJDA 5IJSA 4KJGA 1KHNA 1ALKA 1N2LA 4LRAA 5EGEA 2W5TA 4MY4A 3Q3QA 3MK2A 1HDHA 5KXAA 3NKRA 1EW8A 3B5QA 4ZG6A 1ZEBA 2W8SA 4NWJA 3NVLA 5GRRA 4GTYA 3WAXA 1URBA 2ANHA 4UOPA 4UORA 4CYRA 3NKQA 3WAVA 1K7HA 4FDJA 1E1ZP 4UPHA 4LRCA 5DLVA 4KJDA 2GLQA 4MIVA 3TWZA 5INHA 3ED4A 5TJ3A 3UN2A 2ZKTA 4LR8A 1KHLA 3KD8A 4N7TA 1KHKA 3E2DA 2XRGA 5L0BA 3NKNA 2GSUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XR9 A;  1ELY A;  1EJJ A;  5IJQ A;  1O98 A;  3M8Z A;  5AJ9 A;  4LRB A;  1HQA A;  2D1G A;  4ZG7 A;  1KH7 A;  3M8W A;  3OT9 A;  4QAX A;  4UPI A;  3WAY A;  5C66 A;  3IGZ B;  1N2K A;  4GTX A;  3NKO A;  4TN0 A;  4ZGA A;  2W5X A;  4UPL A;  1ELX A;  3NKP A;  3NKM A;  4LR9 A;  4UOO A;  4B56 A;  3SZY A;  3LXQ A;  1E3C P;  5LRN A;  1E33 P;  2X98 A;  1AUK A;  3BDG B;  4ZG9 A;  1AJC A;  3IDD A;  4LR7 A;  5EGH A;  2GSO A;  3TG0 A;  3UO0 A;  4CYS A;  1SHQ A;  2IUC A;  4KM4 A;  4GTW A;  1KH9 A;  2W5Q A;  4NWX A;  1EW2 A;  1B8J A;  5K4P A;  3T00 A;  5DLW A;  1ALI A;  4CXK A;  3M8Y A;  4LRD A;  2W5R A;  2VQR A;  1AJA A;  1URA A;  1ED9 A;  4UPK A;  2IFY A;  4CXU A;  5LIA A;  2W5V A;  1ED8 A;  1EW9 A;  3T01 A;  3BDH A;  3UNY A;  3WAW A;  1ZED A;  3DYC A;  3MK1 A;  1Y7A A;  4LRE A;  1ANJ A;  1KH5 A;  1ALH A;  3M7V A;  3CMR A;  1ZEF A;  4MHX A;  5L0E A;  1ALJ A;  1O99 A;  4YR1 A;  3TX0 A;  2W8D A;  2QZU A;  4LR2 A;  4CXS A;  3BDF A;  3IGY B;  5LQQ A;  2G9Y A;  1E2S P;  3MK0 A;  1EQJ A;  4LRF A;  5LRM A;  2IUC B;  3WBH A;  1KH4 A;  2GSN A;  4FDI A;  3SZZ A;  2GA3 A;  4KAY A;  1ELZ A;  5DLT A;  3T02 A;  3UN5 A;  1KHJ A;  1ANI A;  3DPC A;  4LQY A;  2W5S A;  1SHN A;  5HRT A;  1FSU A;  2RH6 A;  3BDG A;  3UN3 A;  4GTZ A;  2W5W A;  1HJK A;  5L0K A;  3A52 A;  1EI6 A;  1AJB A;  1P49 A;  1Y6V A;  4KAV A;  5GOV A;  1AJD A;  5IJS A;  4KJG A;  1KHN A;  1ALK A;  1N2L A;  4LRA A;  5EGE A;  2W5T A;  4MY4 A;  3Q3Q A;  3MK2 A;  1HDH A;  5KXA A;  3NKR A;  1EW8 A;  3B5Q A;  4ZG6 A;  1ZEB A;  2W8S A;  4NWJ A;  3NVL A;  5GRR A;  4GTY A;  3WAX A;  1URB A;  2ANH A;  4UOP A;  4UOR A;  4CYR A;  3NKQ A;  3WAV A;  1K7H A;  4FDJ A;  1E1Z P;  4UPH A;  4LRC A;  5DLV A;  4KJD A;  2GLQ A;  4MIV A;  3TWZ A;  5INH A;  3ED4 A;  5TJ3 A;  3UN2 A;  2ZKT A;  4LR8 A;  1KHL A;  3KD8 A;  4N7T A;  1KHK A;  3E2D A;  2XRG A;  5L0B A;  3NKN A;  2GSU A; 
#chains in the Genus database with same CATH topology
 2XR9 A;  1ELY A;  1EJJ A;  5IJQ A;  1O98 A;  3M8Z A;  5AJ9 A;  4LRB A;  1HQA A;  2D1G A;  4ZG7 A;  1KH7 A;  3M8W A;  3OT9 A;  4QAX A;  4UPI A;  3WAY A;  5C66 A;  3IGZ B;  1N2K A;  4GTX A;  3NKO A;  4TN0 A;  4ZGA A;  2W5X A;  4UPL A;  1ELX A;  3NKP A;  3NKM A;  4LR9 A;  4UOO A;  4B56 A;  3SZY A;  3LXQ A;  1E3C P;  5LRN A;  1E33 P;  2X98 A;  1AUK A;  3BDG B;  4ZG9 A;  1AJC A;  3IDD A;  4LR7 A;  5EGH A;  2GSO A;  3TG0 A;  3UO0 A;  4CYS A;  1SHQ A;  2IUC A;  4KM4 A;  4GTW A;  1KH9 A;  2W5Q A;  4NWX A;  1EW2 A;  1B8J A;  5K4P A;  3T00 A;  5DLW A;  1ALI A;  4CXK A;  3M8Y A;  4LRD A;  2W5R A;  2VQR A;  1AJA A;  1URA A;  1ED9 A;  4UPK A;  2IFY A;  4CXU A;  5LIA A;  2W5V A;  1ED8 A;  1EW9 A;  3T01 A;  3BDH A;  3UNY A;  3WAW A;  1ZED A;  3DYC A;  3MK1 A;  1Y7A A;  4LRE A;  1ANJ A;  1KH5 A;  1ALH A;  3M7V A;  3CMR A;  1ZEF A;  4MHX A;  5L0E A;  1ALJ A;  1O99 A;  4YR1 A;  3TX0 A;  2W8D A;  2QZU A;  4LR2 A;  4CXS A;  3BDF A;  3IGY B;  5LQQ A;  2G9Y A;  1E2S P;  3MK0 A;  1EQJ A;  4LRF A;  5LRM A;  2IUC B;  3WBH A;  1KH4 A;  2GSN A;  4FDI A;  3SZZ A;  2GA3 A;  4KAY A;  1ELZ A;  5DLT A;  3T02 A;  3UN5 A;  1KHJ A;  1ANI A;  3DPC A;  4LQY A;  2W5S A;  1SHN A;  5HRT A;  1FSU A;  2RH6 A;  3BDG A;  3UN3 A;  4GTZ A;  2W5W A;  1HJK A;  5L0K A;  3A52 A;  1EI6 A;  1AJB A;  1P49 A;  1Y6V A;  4KAV A;  5GOV A;  1AJD A;  5IJS A;  4KJG A;  1KHN A;  1ALK A;  1N2L A;  4LRA A;  5EGE A;  2W5T A;  4MY4 A;  3Q3Q A;  3MK2 A;  1HDH A;  5KXA A;  3NKR A;  1EW8 A;  3B5Q A;  4ZG6 A;  1ZEB A;  2W8S A;  4NWJ A;  3NVL A;  5GRR A;  4GTY A;  3WAX A;  1URB A;  2ANH A;  4UOP A;  4UOR A;  4CYR A;  3NKQ A;  3WAV A;  1K7H A;  4FDJ A;  1E1Z P;  4UPH A;  4LRC A;  5DLV A;  4KJD A;  2GLQ A;  4MIV A;  3TWZ A;  5INH A;  3ED4 A;  5TJ3 A;  3UN2 A;  2ZKT A;  4LR8 A;  1KHL A;  3KD8 A;  4N7T A;  1KHK A;  3E2D A;  2XRG A;  5L0B A;  3NKN A;  2GSU A; 
#chains in the Genus database with same CATH homology
 2XR9 A;  1ELY A;  1EJJ A;  5IJQ A;  1O98 A;  3M8Z A;  5AJ9 A;  4LRB A;  1HQA A;  2D1G A;  4ZG7 A;  1KH7 A;  3M8W A;  3OT9 A;  4QAX A;  4UPI A;  3WAY A;  5C66 A;  3IGZ B;  1N2K A;  4GTX A;  3NKO A;  4TN0 A;  4ZGA A;  2W5X A;  4UPL A;  1ELX A;  3NKP A;  3NKM A;  4LR9 A;  4UOO A;  4B56 A;  3SZY A;  3LXQ A;  1E3C P;  5LRN A;  1E33 P;  2X98 A;  1AUK A;  3BDG B;  4ZG9 A;  1AJC A;  3IDD A;  4LR7 A;  5EGH A;  2GSO A;  3TG0 A;  3UO0 A;  4CYS A;  1SHQ A;  2IUC A;  4KM4 A;  4GTW A;  1KH9 A;  2W5Q A;  4NWX A;  1EW2 A;  1B8J A;  5K4P A;  3T00 A;  5DLW A;  1ALI A;  4CXK A;  3M8Y A;  4LRD A;  2W5R A;  2VQR A;  1AJA A;  1URA A;  1ED9 A;  4UPK A;  2IFY A;  4CXU A;  5LIA A;  2W5V A;  1ED8 A;  1EW9 A;  3T01 A;  3BDH A;  3UNY A;  3WAW A;  1ZED A;  3DYC A;  3MK1 A;  1Y7A A;  4LRE A;  1ANJ A;  1KH5 A;  1ALH A;  3M7V A;  3CMR A;  1ZEF A;  4MHX A;  5L0E A;  1ALJ A;  1O99 A;  4YR1 A;  3TX0 A;  2W8D A;  2QZU A;  4LR2 A;  4CXS A;  3BDF A;  3IGY B;  5LQQ A;  2G9Y A;  1E2S P;  3MK0 A;  1EQJ A;  4LRF A;  5LRM A;  2IUC B;  3WBH A;  1KH4 A;  2GSN A;  4FDI A;  3SZZ A;  2GA3 A;  4KAY A;  1ELZ A;  5DLT A;  3T02 A;  3UN5 A;  1KHJ A;  1ANI A;  3DPC A;  4LQY A;  2W5S A;  1SHN A;  5HRT A;  1FSU A;  2RH6 A;  3BDG A;  3UN3 A;  4GTZ A;  2W5W A;  1HJK A;  5L0K A;  3A52 A;  1EI6 A;  1AJB A;  1P49 A;  1Y6V A;  4KAV A;  5GOV A;  1AJD A;  5IJS A;  4KJG A;  1KHN A;  1ALK A;  1N2L A;  4LRA A;  5EGE A;  2W5T A;  4MY4 A;  3Q3Q A;  3MK2 A;  1HDH A;  5KXA A;  3NKR A;  1EW8 A;  3B5Q A;  4ZG6 A;  1ZEB A;  2W8S A;  4NWJ A;  3NVL A;  5GRR A;  4GTY A;  3WAX A;  1URB A;  2ANH A;  4UOP A;  4UOR A;  4CYR A;  3NKQ A;  3WAV A;  1K7H A;  4FDJ A;  1E1Z P;  4UPH A;  4LRC A;  5DLV A;  4KJD A;  2GLQ A;  4MIV A;  3TWZ A;  5INH A;  3ED4 A;  5TJ3 A;  3UN2 A;  2ZKT A;  4LR8 A;  1KHL A;  3KD8 A;  4N7T A;  1KHK A;  3E2D A;  2XRG A;  5L0B A;  3NKN A;  2GSU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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