1KH4A

E. coli alkaline phosphatase mutant (d330n) in complex with phosphate
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
444
structure length
444
Chain Sequence
b'VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 154
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh4A00
5INHA 1AJAA 4MY4A 1KHKA 1AJBA 1E2SP 2X98A 3BDFA 1ALJA 3MK0A 1KHLA 4TN0A 2ZKTA 2IUCB 3T01A 3SZYA 5KXAA 4KAVA 1KH7A 3UO0A 3MK1A 4LRDA 2GSOA 3WAYA 1EI6A 4LR9A 5C66A 5GRRA 2QZUA 1KHNA 3TWZA 1ELYA 3UN5A 5L0BA 4UORA 4GTYA 5L0EA 1EW8A 1SHQA 4UOPA 3WBHA 2RH6A 4UPIA 5LIAA 1K7HA 4CYRA 3UN3A 2IFYA 1E3CP 1URAA 1EJJA 1KHJA 2W5WA 5K4PA 4KJDA 1HJKA 1ALKA 1HDHA 1KH4A 3NKPA 2GSNA 5TJ3A 5LRMA 3UN2A 1AUKA 3NKOA 4KM4A 1FSUA 3DYCA 4YR1A 3TG0A 3NKNA 4LRFA 3DPCA 4UPKA 1EW2A 1N2KA 3BDHA 5EGHA 2ANHA 3MK2A 1P49A 3IGYB 4NWXA 5DLVA 4LRBA 4UPLA 1EQJA 4LQYA 5LRNA 4GTWA 1B8JA 3M7VA 1ZEFA 2W5SA 3ED4A 3UNYA 2XR9A 4QAXA 3LXQA 1Y7AA 2G9YA 5DLTA 5LQQA 4CYSA 5IJQA 1ELXA 4LRAA 3WAVA 3TX0A 1E33P 1ANJA 3BDGA 3B5QA 3WAWA 3M8YA 3KD8A 1KH9A 2GA3A 3OT9A 2W8SA 3NKMA 5AJ9A 4CXUA 4B56A 3M8WA 4FDJA 4FDIA 3T00A 1ANIA 1EW9A 5HRTA 1HQAA 2W5QA 3NKRA 2W5RA 4ZG9A 1E1ZP 4ZG7A 4LR8A 1O98A 3CMRA 4KAYA 1URBA 5L0KA 4GTXA 2W5VA 1ED8A 3BDGB 4UPHA 3E2DA 4CXKA 2W5XA 2XRGA 2GSUA 3WAXA 5EGEA 4MIVA 4LR2A 1KH5A 4NWJA 2D1GA 3M8ZA 4MHXA 1ELZA 5DLWA 4N7TA 1AJDA 4KJGA 5GOVA 1O99A 1AJCA 1Y6VA 2W5TA 2IUCA 1ZEBA 4GTZA 4CXSA 4ZG6A 1N2LA 3NVLA 1ALIA 3T02A 3IDDA 4LREA 3Q3QA 2GLQA 1SHNA 4LRCA 1ED9A 3IGZB 2W8DA 1ZEDA 2VQRA 3A52A 3NKQA 4LR7A 1ALHA 4UOOA 4ZGAA 5IJSA 3SZZA
chains in the Genus database with same CATH superfamily
5INHA 1AJAA 4MY4A 1KHKA 1AJBA 1E2SP 2X98A 3BDFA 1ALJA 3MK0A 1KHLA 4TN0A 2ZKTA 2IUCB 3T01A 3SZYA 5KXAA 4KAVA 1KH7A 3UO0A 3MK1A 4LRDA 2GSOA 3WAYA 1EI6A 4LR9A 5C66A 5GRRA 2QZUA 1KHNA 3TWZA 1ELYA 3UN5A 5L0BA 4UORA 4GTYA 5L0EA 1EW8A 1SHQA 4UOPA 3WBHA 2RH6A 4UPIA 5LIAA 1K7HA 4CYRA 3UN3A 2IFYA 1E3CP 1URAA 1EJJA 1KHJA 2W5WA 5K4PA 4KJDA 1HJKA 1ALKA 1HDHA 1KH4A 3NKPA 2GSNA 5TJ3A 5LRMA 3UN2A 1AUKA 3NKOA 4KM4A 1FSUA 3DYCA 4YR1A 3TG0A 3NKNA 4LRFA 3DPCA 4UPKA 1EW2A 1N2KA 3BDHA 5EGHA 2ANHA 3MK2A 1P49A 3IGYB 4NWXA 5DLVA 4LRBA 4UPLA 1EQJA 4LQYA 5LRNA 4GTWA 1B8JA 3M7VA 1ZEFA 2W5SA 3ED4A 3UNYA 2XR9A 4QAXA 3LXQA 1Y7AA 2G9YA 5DLTA 5LQQA 4CYSA 5IJQA 1ELXA 4LRAA 3WAVA 3TX0A 1E33P 1ANJA 3BDGA 3B5QA 3WAWA 3M8YA 3KD8A 1KH9A 2GA3A 3OT9A 2W8SA 3NKMA 5AJ9A 4CXUA 4B56A 3M8WA 4FDJA 4FDIA 3T00A 1ANIA 1EW9A 5HRTA 1HQAA 2W5QA 3NKRA 2W5RA 4ZG9A 1E1ZP 4ZG7A 4LR8A 1O98A 3CMRA 4KAYA 1URBA 5L0KA 4GTXA 2W5VA 1ED8A 3BDGB 4UPHA 3E2DA 4CXKA 2W5XA 2XRGA 2GSUA 3WAXA 5EGEA 4MIVA 4LR2A 1KH5A 4NWJA 2D1GA 3M8ZA 4MHXA 1ELZA 5DLWA 4N7TA 1AJDA 4KJGA 5GOVA 1O99A 1AJCA 1Y6VA 2W5TA 2IUCA 1ZEBA 4GTZA 4CXSA 4ZG6A 1N2LA 3NVLA 1ALIA 3T02A 3IDDA 4LREA 3Q3QA 2GLQA 1SHNA 4LRCA 1ED9A 3IGZB 2W8DA 1ZEDA 2VQRA 3A52A 3NKQA 4LR7A 1ALHA 4UOOA 4ZGAA 5IJSA 3SZZA
chains in the Genus database with same CATH topology
5INHA 1AJAA 4MY4A 1KHKA 1AJBA 1E2SP 2X98A 3BDFA 1ALJA 3MK0A 1KHLA 4TN0A 2ZKTA 2IUCB 3T01A 3SZYA 5KXAA 4KAVA 1KH7A 3UO0A 3MK1A 4LRDA 2GSOA 3WAYA 1EI6A 4LR9A 5C66A 5GRRA 2QZUA 1KHNA 3TWZA 1ELYA 3UN5A 5L0BA 4UORA 4GTYA 5L0EA 1EW8A 1SHQA 4UOPA 3WBHA 2RH6A 4UPIA 5LIAA 1K7HA 4CYRA 3UN3A 2IFYA 1E3CP 1URAA 1EJJA 1KHJA 2W5WA 5K4PA 4KJDA 1HJKA 1ALKA 1HDHA 1KH4A 3NKPA 2GSNA 5TJ3A 5LRMA 3UN2A 1AUKA 3NKOA 4KM4A 1FSUA 3DYCA 4YR1A 3TG0A 3NKNA 4LRFA 3DPCA 4UPKA 1EW2A 1N2KA 3BDHA 5EGHA 2ANHA 3MK2A 1P49A 3IGYB 4NWXA 5DLVA 4LRBA 4UPLA 1EQJA 4LQYA 5LRNA 4GTWA 1B8JA 3M7VA 1ZEFA 2W5SA 3ED4A 3UNYA 2XR9A 4QAXA 3LXQA 1Y7AA 2G9YA 5DLTA 5LQQA 4CYSA 5IJQA 1ELXA 4LRAA 3WAVA 3TX0A 1E33P 1ANJA 3BDGA 3B5QA 3WAWA 3M8YA 3KD8A 1KH9A 2GA3A 3OT9A 2W8SA 3NKMA 5AJ9A 4CXUA 4B56A 3M8WA 4FDJA 4FDIA 3T00A 1ANIA 1EW9A 5HRTA 1HQAA 2W5QA 3NKRA 2W5RA 4ZG9A 1E1ZP 4ZG7A 4LR8A 1O98A 3CMRA 4KAYA 1URBA 5L0KA 4GTXA 2W5VA 1ED8A 3BDGB 4UPHA 3E2DA 4CXKA 2W5XA 2XRGA 2GSUA 3WAXA 5EGEA 4MIVA 4LR2A 1KH5A 4NWJA 2D1GA 3M8ZA 4MHXA 1ELZA 5DLWA 4N7TA 1AJDA 4KJGA 5GOVA 1O99A 1AJCA 1Y6VA 2W5TA 2IUCA 1ZEBA 4GTZA 4CXSA 4ZG6A 1N2LA 3NVLA 1ALIA 3T02A 3IDDA 4LREA 3Q3QA 2GLQA 1SHNA 4LRCA 1ED9A 3IGZB 2W8DA 1ZEDA 2VQRA 3A52A 3NKQA 4LR7A 1ALHA 4UOOA 4ZGAA 5IJSA 3SZZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5INH A;  1AJA A;  4MY4 A;  1KHK A;  1AJB A;  1E2S P;  2X98 A;  3BDF A;  1ALJ A;  3MK0 A;  1KHL A;  4TN0 A;  2ZKT A;  2IUC B;  3T01 A;  3SZY A;  5KXA A;  4KAV A;  1KH7 A;  3UO0 A;  3MK1 A;  4LRD A;  2GSO A;  3WAY A;  1EI6 A;  4LR9 A;  5C66 A;  5GRR A;  2QZU A;  1KHN A;  3TWZ A;  1ELY A;  3UN5 A;  5L0B A;  4UOR A;  4GTY A;  5L0E A;  1EW8 A;  1SHQ A;  4UOP A;  3WBH A;  2RH6 A;  4UPI A;  5LIA A;  1K7H A;  4CYR A;  3UN3 A;  2IFY A;  1E3C P;  1URA A;  1EJJ A;  1KHJ A;  2W5W A;  5K4P A;  4KJD A;  1HJK A;  1ALK A;  1HDH A;  1KH4 A;  3NKP A;  2GSN A;  5TJ3 A;  5LRM A;  3UN2 A;  1AUK A;  3NKO A;  4KM4 A;  1FSU A;  3DYC A;  4YR1 A;  3TG0 A;  3NKN A;  4LRF A;  3DPC A;  4UPK A;  1EW2 A;  1N2K A;  3BDH A;  5EGH A;  2ANH A;  3MK2 A;  1P49 A;  3IGY B;  4NWX A;  5DLV A;  4LRB A;  4UPL A;  1EQJ A;  4LQY A;  5LRN A;  4GTW A;  1B8J A;  3M7V A;  1ZEF A;  2W5S A;  3ED4 A;  3UNY A;  2XR9 A;  4QAX A;  3LXQ A;  1Y7A A;  2G9Y A;  5DLT A;  5LQQ A;  4CYS A;  5IJQ A;  1ELX A;  4LRA A;  3WAV A;  3TX0 A;  1E33 P;  1ANJ A;  3BDG A;  3B5Q A;  3WAW A;  3M8Y A;  3KD8 A;  1KH9 A;  2GA3 A;  3OT9 A;  2W8S A;  3NKM A;  5AJ9 A;  4CXU A;  4B56 A;  3M8W A;  4FDJ A;  4FDI A;  3T00 A;  1ANI A;  1EW9 A;  5HRT A;  1HQA A;  2W5Q A;  3NKR A;  2W5R A;  4ZG9 A;  1E1Z P;  4ZG7 A;  4LR8 A;  1O98 A;  3CMR A;  4KAY A;  1URB A;  5L0K A;  4GTX A;  2W5V A;  1ED8 A;  3BDG B;  4UPH A;  3E2D A;  4CXK A;  2W5X A;  2XRG A;  2GSU A;  3WAX A;  5EGE A;  4MIV A;  4LR2 A;  1KH5 A;  4NWJ A;  2D1G A;  3M8Z A;  4MHX A;  1ELZ A;  5DLW A;  4N7T A;  1AJD A;  4KJG A;  5GOV A;  1O99 A;  1AJC A;  1Y6V A;  2W5T A;  2IUC A;  1ZEB A;  4GTZ A;  4CXS A;  4ZG6 A;  1N2L A;  3NVL A;  1ALI A;  3T02 A;  3IDD A;  4LRE A;  3Q3Q A;  2GLQ A;  1SHN A;  4LRC A;  1ED9 A;  3IGZ B;  2W8D A;  1ZED A;  2VQR A;  3A52 A;  3NKQ A;  4LR7 A;  1ALH A;  4UOO A;  4ZGA A;  5IJS A;  3SZZ A; 
#chains in the Genus database with same CATH topology
 5INH A;  1AJA A;  4MY4 A;  1KHK A;  1AJB A;  1E2S P;  2X98 A;  3BDF A;  1ALJ A;  3MK0 A;  1KHL A;  4TN0 A;  2ZKT A;  2IUC B;  3T01 A;  3SZY A;  5KXA A;  4KAV A;  1KH7 A;  3UO0 A;  3MK1 A;  4LRD A;  2GSO A;  3WAY A;  1EI6 A;  4LR9 A;  5C66 A;  5GRR A;  2QZU A;  1KHN A;  3TWZ A;  1ELY A;  3UN5 A;  5L0B A;  4UOR A;  4GTY A;  5L0E A;  1EW8 A;  1SHQ A;  4UOP A;  3WBH A;  2RH6 A;  4UPI A;  5LIA A;  1K7H A;  4CYR A;  3UN3 A;  2IFY A;  1E3C P;  1URA A;  1EJJ A;  1KHJ A;  2W5W A;  5K4P A;  4KJD A;  1HJK A;  1ALK A;  1HDH A;  1KH4 A;  3NKP A;  2GSN A;  5TJ3 A;  5LRM A;  3UN2 A;  1AUK A;  3NKO A;  4KM4 A;  1FSU A;  3DYC A;  4YR1 A;  3TG0 A;  3NKN A;  4LRF A;  3DPC A;  4UPK A;  1EW2 A;  1N2K A;  3BDH A;  5EGH A;  2ANH A;  3MK2 A;  1P49 A;  3IGY B;  4NWX A;  5DLV A;  4LRB A;  4UPL A;  1EQJ A;  4LQY A;  5LRN A;  4GTW A;  1B8J A;  3M7V A;  1ZEF A;  2W5S A;  3ED4 A;  3UNY A;  2XR9 A;  4QAX A;  3LXQ A;  1Y7A A;  2G9Y A;  5DLT A;  5LQQ A;  4CYS A;  5IJQ A;  1ELX A;  4LRA A;  3WAV A;  3TX0 A;  1E33 P;  1ANJ A;  3BDG A;  3B5Q A;  3WAW A;  3M8Y A;  3KD8 A;  1KH9 A;  2GA3 A;  3OT9 A;  2W8S A;  3NKM A;  5AJ9 A;  4CXU A;  4B56 A;  3M8W A;  4FDJ A;  4FDI A;  3T00 A;  1ANI A;  1EW9 A;  5HRT A;  1HQA A;  2W5Q A;  3NKR A;  2W5R A;  4ZG9 A;  1E1Z P;  4ZG7 A;  4LR8 A;  1O98 A;  3CMR A;  4KAY A;  1URB A;  5L0K A;  4GTX A;  2W5V A;  1ED8 A;  3BDG B;  4UPH A;  3E2D A;  4CXK A;  2W5X A;  2XRG A;  2GSU A;  3WAX A;  5EGE A;  4MIV A;  4LR2 A;  1KH5 A;  4NWJ A;  2D1G A;  3M8Z A;  4MHX A;  1ELZ A;  5DLW A;  4N7T A;  1AJD A;  4KJG A;  5GOV A;  1O99 A;  1AJC A;  1Y6V A;  2W5T A;  2IUC A;  1ZEB A;  4GTZ A;  4CXS A;  4ZG6 A;  1N2L A;  3NVL A;  1ALI A;  3T02 A;  3IDD A;  4LRE A;  3Q3Q A;  2GLQ A;  1SHN A;  4LRC A;  1ED9 A;  3IGZ B;  2W8D A;  1ZED A;  2VQR A;  3A52 A;  3NKQ A;  4LR7 A;  1ALH A;  4UOO A;  4ZGA A;  5IJS A;  3SZZ A; 
#chains in the Genus database with same CATH homology
 5INH A;  1AJA A;  4MY4 A;  1KHK A;  1AJB A;  1E2S P;  2X98 A;  3BDF A;  1ALJ A;  3MK0 A;  1KHL A;  4TN0 A;  2ZKT A;  2IUC B;  3T01 A;  3SZY A;  5KXA A;  4KAV A;  1KH7 A;  3UO0 A;  3MK1 A;  4LRD A;  2GSO A;  3WAY A;  1EI6 A;  4LR9 A;  5C66 A;  5GRR A;  2QZU A;  1KHN A;  3TWZ A;  1ELY A;  3UN5 A;  5L0B A;  4UOR A;  4GTY A;  5L0E A;  1EW8 A;  1SHQ A;  4UOP A;  3WBH A;  2RH6 A;  4UPI A;  5LIA A;  1K7H A;  4CYR A;  3UN3 A;  2IFY A;  1E3C P;  1URA A;  1EJJ A;  1KHJ A;  2W5W A;  5K4P A;  4KJD A;  1HJK A;  1ALK A;  1HDH A;  1KH4 A;  3NKP A;  2GSN A;  5TJ3 A;  5LRM A;  3UN2 A;  1AUK A;  3NKO A;  4KM4 A;  1FSU A;  3DYC A;  4YR1 A;  3TG0 A;  3NKN A;  4LRF A;  3DPC A;  4UPK A;  1EW2 A;  1N2K A;  3BDH A;  5EGH A;  2ANH A;  3MK2 A;  1P49 A;  3IGY B;  4NWX A;  5DLV A;  4LRB A;  4UPL A;  1EQJ A;  4LQY A;  5LRN A;  4GTW A;  1B8J A;  3M7V A;  1ZEF A;  2W5S A;  3ED4 A;  3UNY A;  2XR9 A;  4QAX A;  3LXQ A;  1Y7A A;  2G9Y A;  5DLT A;  5LQQ A;  4CYS A;  5IJQ A;  1ELX A;  4LRA A;  3WAV A;  3TX0 A;  1E33 P;  1ANJ A;  3BDG A;  3B5Q A;  3WAW A;  3M8Y A;  3KD8 A;  1KH9 A;  2GA3 A;  3OT9 A;  2W8S A;  3NKM A;  5AJ9 A;  4CXU A;  4B56 A;  3M8W A;  4FDJ A;  4FDI A;  3T00 A;  1ANI A;  1EW9 A;  5HRT A;  1HQA A;  2W5Q A;  3NKR A;  2W5R A;  4ZG9 A;  1E1Z P;  4ZG7 A;  4LR8 A;  1O98 A;  3CMR A;  4KAY A;  1URB A;  5L0K A;  4GTX A;  2W5V A;  1ED8 A;  3BDG B;  4UPH A;  3E2D A;  4CXK A;  2W5X A;  2XRG A;  2GSU A;  3WAX A;  5EGE A;  4MIV A;  4LR2 A;  1KH5 A;  4NWJ A;  2D1G A;  3M8Z A;  4MHX A;  1ELZ A;  5DLW A;  4N7T A;  1AJD A;  4KJG A;  5GOV A;  1O99 A;  1AJC A;  1Y6V A;  2W5T A;  2IUC A;  1ZEB A;  4GTZ A;  4CXS A;  4ZG6 A;  1N2L A;  3NVL A;  1ALI A;  3T02 A;  3IDD A;  4LRE A;  3Q3Q A;  2GLQ A;  1SHN A;  4LRC A;  1ED9 A;  3IGZ B;  2W8D A;  1ZED A;  2VQR A;  3A52 A;  3NKQ A;  4LR7 A;  1ALH A;  4UOO A;  4ZGA A;  5IJS A;  3SZZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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