1KH4A

E. coli alkaline phosphatase mutant (d330n) in complex with phosphate
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
Knots found
sequence length
444
structure length
444
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
total genus 154
structure length 444
sequence length 444
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh4A00
4UPIA 2W5QA 5GOVA 3WAXA 1KHJA 4YR1A 3OT9A 5DLWA 2D1GA 2QZUA 3WAWA 4KM4A 1ELYA 3BDHA 4UPKA 1ZEBA 3ED4A 1Y7AA 4QAXA 4UPLA 5K4PA 3Q3QA 1N2LA 3IDDA 2W5XA 3M7VA 3IGYB 3NKQA 1N2KA 1E3CP 3BDGB 2W5VA 3NKNA 5DLTA 3NKPA 5TJ3A 3SZYA 3MK2A 1ZEFA 4LR7A 3SZZA 2W5SA 5L0EA 3NKOA 3UN2A 2XR9A 4ZGAA 1EW9A 4CXUA 4KAVA 1SHQA 1AJDA 5L0BA 4MHXA 4LRFA 3UN3A 3UO0A 3KD8A 5DLVA 2IUCA 1URBA 2GSNA 5IJQA 4CYRA 4LRBA 4CXKA 2W5WA 3TWZA 3T01A 1O99A 2GSOA 5LIAA 1ANJA 2W8DA 2W5RA 2VQRA 3LXQA 1ALHA 3NKRA 4ZG7A 5LRMA 4GTXA 5EGEA 3TG0A 2XRGA 1P49A 4LRDA 4KAYA 4TN0A 1EJJA 3MK0A 1ZEDA 4FDJA 2W8SA 4LREA 2X98A 3DYCA 3T00A 1KH4A 1ANIA 1HQAA 3NVLA 1AJAA 4LR9A 1AJCA 1B8JA 1EW8A 5LRNA 4LR2A 3WAVA 1ED8A 3E2DA 3IGZB 4NWXA 3WAYA 1SHNA 2ANHA 1HDHA 3M8WA 3MK1A 1E33P 1E2SP 3UNYA 1KH9A 5INHA 1O98A 3WBHA 5GRRA 1K7HA 1E1ZP 1FSUA 1KHNA 4UPHA 5KXAA 3TX0A 1URAA 1KHKA 2GA3A 3B5QA 3A52A 4MY4A 1ALJA 2RH6A 1KH5A 2W5TA 3M8ZA 3UN5A 1ED9A 2IUCB 4FDIA 4MIVA 3T02A 5L0KA 3DPCA 4LRCA 1ALKA 5HRTA 1ELZA 5EGHA 1AUKA 1KHLA 4LQYA 5C66A 1EI6A 1EQJA 1KH7A 2GLQA 3CMRA 4GTWA 4UOPA 4CYSA 3NKMA 3BDFA 1EW2A 5LQQA 4LR8A 4N7TA 4KJDA 1HJKA 2ZKTA 4NWJA 2G9YA 3M8YA 4UOOA 4CXSA 4UORA 4B56A 1AJBA 1ELXA 2GSUA 4ZG9A 1ALIA 3BDGA 1Y6VA 4GTZA 2IFYA 5AJ9A 4GTYA 4ZG6A 4KJGA 5IJSA 4LRAA
chains in the Genus database with same CATH superfamily
4UPIA 2W5QA 5GOVA 3WAXA 1KHJA 4YR1A 3OT9A 5DLWA 2D1GA 2QZUA 3WAWA 4KM4A 1ELYA 3BDHA 4UPKA 1ZEBA 3ED4A 1Y7AA 4QAXA 4UPLA 5K4PA 3Q3QA 1N2LA 3IDDA 2W5XA 3M7VA 3IGYB 3NKQA 1N2KA 1E3CP 3BDGB 2W5VA 3NKNA 5DLTA 3NKPA 5TJ3A 3SZYA 3MK2A 1ZEFA 4LR7A 3SZZA 2W5SA 5L0EA 3NKOA 3UN2A 2XR9A 4ZGAA 1EW9A 4CXUA 4KAVA 1SHQA 1AJDA 5L0BA 4MHXA 4LRFA 3UN3A 3UO0A 3KD8A 5DLVA 2IUCA 1URBA 2GSNA 5IJQA 4CYRA 4LRBA 4CXKA 2W5WA 3TWZA 3T01A 1O99A 2GSOA 5LIAA 1ANJA 2W8DA 2W5RA 2VQRA 3LXQA 1ALHA 3NKRA 4ZG7A 5LRMA 4GTXA 5EGEA 3TG0A 2XRGA 1P49A 4LRDA 4KAYA 4TN0A 1EJJA 3MK0A 1ZEDA 4FDJA 2W8SA 4LREA 2X98A 3DYCA 3T00A 1KH4A 1ANIA 1HQAA 3NVLA 1AJAA 4LR9A 1AJCA 1B8JA 1EW8A 5LRNA 4LR2A 3WAVA 1ED8A 3E2DA 3IGZB 4NWXA 3WAYA 1SHNA 2ANHA 1HDHA 3M8WA 3MK1A 1E33P 1E2SP 3UNYA 1KH9A 5INHA 1O98A 3WBHA 5GRRA 1K7HA 1E1ZP 1FSUA 1KHNA 4UPHA 5KXAA 3TX0A 1URAA 1KHKA 2GA3A 3B5QA 3A52A 4MY4A 1ALJA 2RH6A 1KH5A 2W5TA 3M8ZA 3UN5A 1ED9A 2IUCB 4FDIA 4MIVA 3T02A 5L0KA 3DPCA 4LRCA 1ALKA 5HRTA 1ELZA 5EGHA 1AUKA 1KHLA 4LQYA 5C66A 1EI6A 1EQJA 1KH7A 2GLQA 3CMRA 4GTWA 4UOPA 4CYSA 3NKMA 3BDFA 1EW2A 5LQQA 4LR8A 4N7TA 4KJDA 1HJKA 2ZKTA 4NWJA 2G9YA 3M8YA 4UOOA 4CXSA 4UORA 4B56A 1AJBA 1ELXA 2GSUA 4ZG9A 1ALIA 3BDGA 1Y6VA 4GTZA 2IFYA 5AJ9A 4GTYA 4ZG6A 4KJGA 5IJSA 4LRAA
chains in the Genus database with same CATH topology
4UPIA 2W5QA 5GOVA 3WAXA 1KHJA 4YR1A 3OT9A 5DLWA 2D1GA 2QZUA 3WAWA 4KM4A 1ELYA 3BDHA 4UPKA 1ZEBA 3ED4A 1Y7AA 4QAXA 4UPLA 5K4PA 3Q3QA 1N2LA 3IDDA 2W5XA 3M7VA 3IGYB 3NKQA 1N2KA 1E3CP 3BDGB 2W5VA 3NKNA 5DLTA 3NKPA 5TJ3A 3SZYA 3MK2A 1ZEFA 4LR7A 3SZZA 2W5SA 5L0EA 3NKOA 3UN2A 2XR9A 4ZGAA 1EW9A 4CXUA 4KAVA 1SHQA 1AJDA 5L0BA 4MHXA 4LRFA 3UN3A 3UO0A 3KD8A 5DLVA 2IUCA 1URBA 2GSNA 5IJQA 4CYRA 4LRBA 4CXKA 2W5WA 3TWZA 3T01A 1O99A 2GSOA 5LIAA 1ANJA 2W8DA 2W5RA 2VQRA 3LXQA 1ALHA 3NKRA 4ZG7A 5LRMA 4GTXA 5EGEA 3TG0A 2XRGA 1P49A 4LRDA 4KAYA 4TN0A 1EJJA 3MK0A 1ZEDA 4FDJA 2W8SA 4LREA 2X98A 3DYCA 3T00A 1KH4A 1ANIA 1HQAA 3NVLA 1AJAA 4LR9A 1AJCA 1B8JA 1EW8A 5LRNA 4LR2A 3WAVA 1ED8A 3E2DA 3IGZB 4NWXA 3WAYA 1SHNA 2ANHA 1HDHA 3M8WA 3MK1A 1E33P 1E2SP 3UNYA 1KH9A 5INHA 1O98A 3WBHA 5GRRA 1K7HA 1E1ZP 1FSUA 1KHNA 4UPHA 5KXAA 3TX0A 1URAA 1KHKA 2GA3A 3B5QA 3A52A 4MY4A 1ALJA 2RH6A 1KH5A 2W5TA 3M8ZA 3UN5A 1ED9A 2IUCB 4FDIA 4MIVA 3T02A 5L0KA 3DPCA 4LRCA 1ALKA 5HRTA 1ELZA 5EGHA 1AUKA 1KHLA 4LQYA 5C66A 1EI6A 1EQJA 1KH7A 2GLQA 3CMRA 4GTWA 4UOPA 4CYSA 3NKMA 3BDFA 1EW2A 5LQQA 4LR8A 4N7TA 4KJDA 1HJKA 2ZKTA 4NWJA 2G9YA 3M8YA 4UOOA 4CXSA 4UORA 4B56A 1AJBA 1ELXA 2GSUA 4ZG9A 1ALIA 3BDGA 1Y6VA 4GTZA 2IFYA 5AJ9A 4GTYA 4ZG6A 4KJGA 5IJSA 4LRAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPI A;  2W5Q A;  5GOV A;  3WAX A;  1KHJ A;  4YR1 A;  3OT9 A;  5DLW A;  2D1G A;  2QZU A;  3WAW A;  4KM4 A;  1ELY A;  3BDH A;  4UPK A;  1ZEB A;  3ED4 A;  1Y7A A;  4QAX A;  4UPL A;  5K4P A;  3Q3Q A;  1N2L A;  3IDD A;  2W5X A;  3M7V A;  3IGY B;  3NKQ A;  1N2K A;  1E3C P;  3BDG B;  2W5V A;  3NKN A;  5DLT A;  3NKP A;  5TJ3 A;  3SZY A;  3MK2 A;  1ZEF A;  4LR7 A;  3SZZ A;  2W5S A;  5L0E A;  3NKO A;  3UN2 A;  2XR9 A;  4ZGA A;  1EW9 A;  4CXU A;  4KAV A;  1SHQ A;  1AJD A;  5L0B A;  4MHX A;  4LRF A;  3UN3 A;  3UO0 A;  3KD8 A;  5DLV A;  2IUC A;  1URB A;  2GSN A;  5IJQ A;  4CYR A;  4LRB A;  4CXK A;  2W5W A;  3TWZ A;  3T01 A;  1O99 A;  2GSO A;  5LIA A;  1ANJ A;  2W8D A;  2W5R A;  2VQR A;  3LXQ A;  1ALH A;  3NKR A;  4ZG7 A;  5LRM A;  4GTX A;  5EGE A;  3TG0 A;  2XRG A;  1P49 A;  4LRD A;  4KAY A;  4TN0 A;  1EJJ A;  3MK0 A;  1ZED A;  4FDJ A;  2W8S A;  4LRE A;  2X98 A;  3DYC A;  3T00 A;  1KH4 A;  1ANI A;  1HQA A;  3NVL A;  1AJA A;  4LR9 A;  1AJC A;  1B8J A;  1EW8 A;  5LRN A;  4LR2 A;  3WAV A;  1ED8 A;  3E2D A;  3IGZ B;  4NWX A;  3WAY A;  1SHN A;  2ANH A;  1HDH A;  3M8W A;  3MK1 A;  1E33 P;  1E2S P;  3UNY A;  1KH9 A;  5INH A;  1O98 A;  3WBH A;  5GRR A;  1K7H A;  1E1Z P;  1FSU A;  1KHN A;  4UPH A;  5KXA A;  3TX0 A;  1URA A;  1KHK A;  2GA3 A;  3B5Q A;  3A52 A;  4MY4 A;  1ALJ A;  2RH6 A;  1KH5 A;  2W5T A;  3M8Z A;  3UN5 A;  1ED9 A;  2IUC B;  4FDI A;  4MIV A;  3T02 A;  5L0K A;  3DPC A;  4LRC A;  1ALK A;  5HRT A;  1ELZ A;  5EGH A;  1AUK A;  1KHL A;  4LQY A;  5C66 A;  1EI6 A;  1EQJ A;  1KH7 A;  2GLQ A;  3CMR A;  4GTW A;  4UOP A;  4CYS A;  3NKM A;  3BDF A;  1EW2 A;  5LQQ A;  4LR8 A;  4N7T A;  4KJD A;  1HJK A;  2ZKT A;  4NWJ A;  2G9Y A;  3M8Y A;  4UOO A;  4CXS A;  4UOR A;  4B56 A;  1AJB A;  1ELX A;  2GSU A;  4ZG9 A;  1ALI A;  3BDG A;  1Y6V A;  4GTZ A;  2IFY A;  5AJ9 A;  4GTY A;  4ZG6 A;  4KJG A;  5IJS A;  4LRA A; 
#chains in the Genus database with same CATH topology
 4UPI A;  2W5Q A;  5GOV A;  3WAX A;  1KHJ A;  4YR1 A;  3OT9 A;  5DLW A;  2D1G A;  2QZU A;  3WAW A;  4KM4 A;  1ELY A;  3BDH A;  4UPK A;  1ZEB A;  3ED4 A;  1Y7A A;  4QAX A;  4UPL A;  5K4P A;  3Q3Q A;  1N2L A;  3IDD A;  2W5X A;  3M7V A;  3IGY B;  3NKQ A;  1N2K A;  1E3C P;  3BDG B;  2W5V A;  3NKN A;  5DLT A;  3NKP A;  5TJ3 A;  3SZY A;  3MK2 A;  1ZEF A;  4LR7 A;  3SZZ A;  2W5S A;  5L0E A;  3NKO A;  3UN2 A;  2XR9 A;  4ZGA A;  1EW9 A;  4CXU A;  4KAV A;  1SHQ A;  1AJD A;  5L0B A;  4MHX A;  4LRF A;  3UN3 A;  3UO0 A;  3KD8 A;  5DLV A;  2IUC A;  1URB A;  2GSN A;  5IJQ A;  4CYR A;  4LRB A;  4CXK A;  2W5W A;  3TWZ A;  3T01 A;  1O99 A;  2GSO A;  5LIA A;  1ANJ A;  2W8D A;  2W5R A;  2VQR A;  3LXQ A;  1ALH A;  3NKR A;  4ZG7 A;  5LRM A;  4GTX A;  5EGE A;  3TG0 A;  2XRG A;  1P49 A;  4LRD A;  4KAY A;  4TN0 A;  1EJJ A;  3MK0 A;  1ZED A;  4FDJ A;  2W8S A;  4LRE A;  2X98 A;  3DYC A;  3T00 A;  1KH4 A;  1ANI A;  1HQA A;  3NVL A;  1AJA A;  4LR9 A;  1AJC A;  1B8J A;  1EW8 A;  5LRN A;  4LR2 A;  3WAV A;  1ED8 A;  3E2D A;  3IGZ B;  4NWX A;  3WAY A;  1SHN A;  2ANH A;  1HDH A;  3M8W A;  3MK1 A;  1E33 P;  1E2S P;  3UNY A;  1KH9 A;  5INH A;  1O98 A;  3WBH A;  5GRR A;  1K7H A;  1E1Z P;  1FSU A;  1KHN A;  4UPH A;  5KXA A;  3TX0 A;  1URA A;  1KHK A;  2GA3 A;  3B5Q A;  3A52 A;  4MY4 A;  1ALJ A;  2RH6 A;  1KH5 A;  2W5T A;  3M8Z A;  3UN5 A;  1ED9 A;  2IUC B;  4FDI A;  4MIV A;  3T02 A;  5L0K A;  3DPC A;  4LRC A;  1ALK A;  5HRT A;  1ELZ A;  5EGH A;  1AUK A;  1KHL A;  4LQY A;  5C66 A;  1EI6 A;  1EQJ A;  1KH7 A;  2GLQ A;  3CMR A;  4GTW A;  4UOP A;  4CYS A;  3NKM A;  3BDF A;  1EW2 A;  5LQQ A;  4LR8 A;  4N7T A;  4KJD A;  1HJK A;  2ZKT A;  4NWJ A;  2G9Y A;  3M8Y A;  4UOO A;  4CXS A;  4UOR A;  4B56 A;  1AJB A;  1ELX A;  2GSU A;  4ZG9 A;  1ALI A;  3BDG A;  1Y6V A;  4GTZ A;  2IFY A;  5AJ9 A;  4GTY A;  4ZG6 A;  4KJG A;  5IJS A;  4LRA A; 
#chains in the Genus database with same CATH homology
 4UPI A;  2W5Q A;  5GOV A;  3WAX A;  1KHJ A;  4YR1 A;  3OT9 A;  5DLW A;  2D1G A;  2QZU A;  3WAW A;  4KM4 A;  1ELY A;  3BDH A;  4UPK A;  1ZEB A;  3ED4 A;  1Y7A A;  4QAX A;  4UPL A;  5K4P A;  3Q3Q A;  1N2L A;  3IDD A;  2W5X A;  3M7V A;  3IGY B;  3NKQ A;  1N2K A;  1E3C P;  3BDG B;  2W5V A;  3NKN A;  5DLT A;  3NKP A;  5TJ3 A;  3SZY A;  3MK2 A;  1ZEF A;  4LR7 A;  3SZZ A;  2W5S A;  5L0E A;  3NKO A;  3UN2 A;  2XR9 A;  4ZGA A;  1EW9 A;  4CXU A;  4KAV A;  1SHQ A;  1AJD A;  5L0B A;  4MHX A;  4LRF A;  3UN3 A;  3UO0 A;  3KD8 A;  5DLV A;  2IUC A;  1URB A;  2GSN A;  5IJQ A;  4CYR A;  4LRB A;  4CXK A;  2W5W A;  3TWZ A;  3T01 A;  1O99 A;  2GSO A;  5LIA A;  1ANJ A;  2W8D A;  2W5R A;  2VQR A;  3LXQ A;  1ALH A;  3NKR A;  4ZG7 A;  5LRM A;  4GTX A;  5EGE A;  3TG0 A;  2XRG A;  1P49 A;  4LRD A;  4KAY A;  4TN0 A;  1EJJ A;  3MK0 A;  1ZED A;  4FDJ A;  2W8S A;  4LRE A;  2X98 A;  3DYC A;  3T00 A;  1KH4 A;  1ANI A;  1HQA A;  3NVL A;  1AJA A;  4LR9 A;  1AJC A;  1B8J A;  1EW8 A;  5LRN A;  4LR2 A;  3WAV A;  1ED8 A;  3E2D A;  3IGZ B;  4NWX A;  3WAY A;  1SHN A;  2ANH A;  1HDH A;  3M8W A;  3MK1 A;  1E33 P;  1E2S P;  3UNY A;  1KH9 A;  5INH A;  1O98 A;  3WBH A;  5GRR A;  1K7H A;  1E1Z P;  1FSU A;  1KHN A;  4UPH A;  5KXA A;  3TX0 A;  1URA A;  1KHK A;  2GA3 A;  3B5Q A;  3A52 A;  4MY4 A;  1ALJ A;  2RH6 A;  1KH5 A;  2W5T A;  3M8Z A;  3UN5 A;  1ED9 A;  2IUC B;  4FDI A;  4MIV A;  3T02 A;  5L0K A;  3DPC A;  4LRC A;  1ALK A;  5HRT A;  1ELZ A;  5EGH A;  1AUK A;  1KHL A;  4LQY A;  5C66 A;  1EI6 A;  1EQJ A;  1KH7 A;  2GLQ A;  3CMR A;  4GTW A;  4UOP A;  4CYS A;  3NKM A;  3BDF A;  1EW2 A;  5LQQ A;  4LR8 A;  4N7T A;  4KJD A;  1HJK A;  2ZKT A;  4NWJ A;  2G9Y A;  3M8Y A;  4UOO A;  4CXS A;  4UOR A;  4B56 A;  1AJB A;  1ELX A;  2GSU A;  4ZG9 A;  1ALI A;  3BDG A;  1Y6V A;  4GTZ A;  2IFY A;  5AJ9 A;  4GTY A;  4ZG6 A;  4KJG A;  5IJS A;  4LRA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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