2W5VA

Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site.
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 128
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5vA00
4GTZA 1HJKA 3B5QA 4LR2A 3SZZA 3UO0A 3NKQA 3TX0A 3MK0A 4LR7A 4MY4A 1B8JA 1O98A 2GLQA 2W5QA 3UN3A 4KJGA 3NKPA 2ZKTA 3WAWA 3SZYA 1E33P 5L0BA 4KJDA 1AUKA 1ED9A 5AJ9A 5EGEA 3WBHA 1URBA 1KHLA 1ZEBA 3M8WA 3WAXA 1N2KA 1FSUA 4QAXA 4CYRA 1EW9A 4UPKA 4UPLA 3ED4A 5TJ3A 1Y7AA 5K4PA 2GA3A 1AJBA 5GRRA 3TG0A 5IJQA 1ED8A 3NKNA 1Y6VA 4CXSA 3M8YA 3DPCA 4FDIA 1KHNA 4ZG7A 1KH5A 1O99A 4B56A 1ANJA 3UN2A 5GOVA 3IGZB 1E1ZP 1EW8A 4CXUA 5LRMA 5LQQA 1KH9A 3TWZA 2IUCB 1N2LA 4FDJA 5DLWA 5DLTA 5LRNA 1KH4A 4LRDA 5C66A 4GTXA 3Q3QA 4LRFA 4N7TA 1AJCA 2W8SA 4MHXA 4MIVA 1ELYA 1URAA 3BDGA 1EQJA 4TN0A 4ZGAA 1ALJA 5LIAA 3IDDA 4CYSA 1K7HA 3OT9A 2GSUA 2X98A 4UOOA 1ELZA 1EJJA 2W5WA 2W5XA 4LRCA 2W5RA 3IGYB 1ANIA 4GTYA 3BDFA 3NVLA 3M8ZA 2G9YA 2XRGA 1AJDA 4CXKA 5IJSA 1KHJA 2IUCA 1SHNA 4GTWA 3T01A 4KAVA 1SHQA 4KM4A 2ANHA 2W5SA 3MK1A 3WAYA 1ALHA 2VQRA 3A52A 5DLVA 3M7VA 4UOPA 3BDHA 3T02A 1ALKA 4LRBA 4LRAA 3WAVA 2XR9A 2GSOA 1EI6A 3KD8A 4YR1A 3NKMA 1EW2A 4LREA 4NWXA 1KH7A 2W8DA 4UPIA 1P49A 1ZEDA 1ZEFA 2RH6A 3LXQA 3UN5A 5L0KA 2QZUA 4KAYA 4LQYA 1HQAA 5L0EA 3DYCA 3E2DA 3NKRA 4LR8A 2W5TA 1ELXA 2W5VA 4UPHA 1KHKA 5KXAA 3MK2A 3UNYA 3NKOA 4ZG9A 4ZG6A 2IFYA 3CMRA 5HRTA 1ALIA 2D1GA 5INHA 5EGHA 4LR9A 2GSNA 4UORA 1E2SP 3BDGB 1AJAA 1E3CP 4NWJA 1HDHA 3T00A
chains in the Genus database with same CATH superfamily
4GTZA 1HJKA 3B5QA 4LR2A 3SZZA 3UO0A 3NKQA 3TX0A 3MK0A 4LR7A 4MY4A 1B8JA 1O98A 2GLQA 2W5QA 3UN3A 4KJGA 3NKPA 2ZKTA 3WAWA 3SZYA 1E33P 5L0BA 4KJDA 1AUKA 1ED9A 5AJ9A 5EGEA 3WBHA 1URBA 1KHLA 1ZEBA 3M8WA 3WAXA 1N2KA 1FSUA 4QAXA 4CYRA 1EW9A 4UPKA 4UPLA 3ED4A 5TJ3A 1Y7AA 5K4PA 2GA3A 1AJBA 5GRRA 3TG0A 5IJQA 1ED8A 3NKNA 1Y6VA 4CXSA 3M8YA 3DPCA 4FDIA 1KHNA 4ZG7A 1KH5A 1O99A 4B56A 1ANJA 3UN2A 5GOVA 3IGZB 1E1ZP 1EW8A 4CXUA 5LRMA 5LQQA 1KH9A 3TWZA 2IUCB 1N2LA 4FDJA 5DLWA 5DLTA 5LRNA 1KH4A 4LRDA 5C66A 4GTXA 3Q3QA 4LRFA 4N7TA 1AJCA 2W8SA 4MHXA 4MIVA 1ELYA 1URAA 3BDGA 1EQJA 4TN0A 4ZGAA 1ALJA 5LIAA 3IDDA 4CYSA 1K7HA 3OT9A 2GSUA 2X98A 4UOOA 1ELZA 1EJJA 2W5WA 2W5XA 4LRCA 2W5RA 3IGYB 1ANIA 4GTYA 3BDFA 3NVLA 3M8ZA 2G9YA 2XRGA 1AJDA 4CXKA 5IJSA 1KHJA 2IUCA 1SHNA 4GTWA 3T01A 4KAVA 1SHQA 4KM4A 2ANHA 2W5SA 3MK1A 3WAYA 1ALHA 2VQRA 3A52A 5DLVA 3M7VA 4UOPA 3BDHA 3T02A 1ALKA 4LRBA 4LRAA 3WAVA 2XR9A 2GSOA 1EI6A 3KD8A 4YR1A 3NKMA 1EW2A 4LREA 4NWXA 1KH7A 2W8DA 4UPIA 1P49A 1ZEDA 1ZEFA 2RH6A 3LXQA 3UN5A 5L0KA 2QZUA 4KAYA 4LQYA 1HQAA 5L0EA 3DYCA 3E2DA 3NKRA 4LR8A 2W5TA 1ELXA 2W5VA 4UPHA 1KHKA 5KXAA 3MK2A 3UNYA 3NKOA 4ZG9A 4ZG6A 2IFYA 3CMRA 5HRTA 1ALIA 2D1GA 5INHA 5EGHA 4LR9A 2GSNA 4UORA 1E2SP 3BDGB 1AJAA 1E3CP 4NWJA 1HDHA 3T00A
chains in the Genus database with same CATH topology
4GTZA 1HJKA 3B5QA 4LR2A 3SZZA 3UO0A 3NKQA 3TX0A 3MK0A 4LR7A 4MY4A 1B8JA 1O98A 2GLQA 2W5QA 3UN3A 4KJGA 3NKPA 2ZKTA 3WAWA 3SZYA 1E33P 5L0BA 4KJDA 1AUKA 1ED9A 5AJ9A 5EGEA 3WBHA 1URBA 1KHLA 1ZEBA 3M8WA 3WAXA 1N2KA 1FSUA 4QAXA 4CYRA 1EW9A 4UPKA 4UPLA 3ED4A 5TJ3A 1Y7AA 5K4PA 2GA3A 1AJBA 5GRRA 3TG0A 5IJQA 1ED8A 3NKNA 1Y6VA 4CXSA 3M8YA 3DPCA 4FDIA 1KHNA 4ZG7A 1KH5A 1O99A 4B56A 1ANJA 3UN2A 5GOVA 3IGZB 1E1ZP 1EW8A 4CXUA 5LRMA 5LQQA 1KH9A 3TWZA 2IUCB 1N2LA 4FDJA 5DLWA 5DLTA 5LRNA 1KH4A 4LRDA 5C66A 4GTXA 3Q3QA 4LRFA 4N7TA 1AJCA 2W8SA 4MHXA 4MIVA 1ELYA 1URAA 3BDGA 1EQJA 4TN0A 4ZGAA 1ALJA 5LIAA 3IDDA 4CYSA 1K7HA 3OT9A 2GSUA 2X98A 4UOOA 1ELZA 1EJJA 2W5WA 2W5XA 4LRCA 2W5RA 3IGYB 1ANIA 4GTYA 3BDFA 3NVLA 3M8ZA 2G9YA 2XRGA 1AJDA 4CXKA 5IJSA 1KHJA 2IUCA 1SHNA 4GTWA 3T01A 4KAVA 1SHQA 4KM4A 2ANHA 2W5SA 3MK1A 3WAYA 1ALHA 2VQRA 3A52A 5DLVA 3M7VA 4UOPA 3BDHA 3T02A 1ALKA 4LRBA 4LRAA 3WAVA 2XR9A 2GSOA 1EI6A 3KD8A 4YR1A 3NKMA 1EW2A 4LREA 4NWXA 1KH7A 2W8DA 4UPIA 1P49A 1ZEDA 1ZEFA 2RH6A 3LXQA 3UN5A 5L0KA 2QZUA 4KAYA 4LQYA 1HQAA 5L0EA 3DYCA 3E2DA 3NKRA 4LR8A 2W5TA 1ELXA 2W5VA 4UPHA 1KHKA 5KXAA 3MK2A 3UNYA 3NKOA 4ZG9A 4ZG6A 2IFYA 3CMRA 5HRTA 1ALIA 2D1GA 5INHA 5EGHA 4LR9A 2GSNA 4UORA 1E2SP 3BDGB 1AJAA 1E3CP 4NWJA 1HDHA 3T00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTZ A;  1HJK A;  3B5Q A;  4LR2 A;  3SZZ A;  3UO0 A;  3NKQ A;  3TX0 A;  3MK0 A;  4LR7 A;  4MY4 A;  1B8J A;  1O98 A;  2GLQ A;  2W5Q A;  3UN3 A;  4KJG A;  3NKP A;  2ZKT A;  3WAW A;  3SZY A;  1E33 P;  5L0B A;  4KJD A;  1AUK A;  1ED9 A;  5AJ9 A;  5EGE A;  3WBH A;  1URB A;  1KHL A;  1ZEB A;  3M8W A;  3WAX A;  1N2K A;  1FSU A;  4QAX A;  4CYR A;  1EW9 A;  4UPK A;  4UPL A;  3ED4 A;  5TJ3 A;  1Y7A A;  5K4P A;  2GA3 A;  1AJB A;  5GRR A;  3TG0 A;  5IJQ A;  1ED8 A;  3NKN A;  1Y6V A;  4CXS A;  3M8Y A;  3DPC A;  4FDI A;  1KHN A;  4ZG7 A;  1KH5 A;  1O99 A;  4B56 A;  1ANJ A;  3UN2 A;  5GOV A;  3IGZ B;  1E1Z P;  1EW8 A;  4CXU A;  5LRM A;  5LQQ A;  1KH9 A;  3TWZ A;  2IUC B;  1N2L A;  4FDJ A;  5DLW A;  5DLT A;  5LRN A;  1KH4 A;  4LRD A;  5C66 A;  4GTX A;  3Q3Q A;  4LRF A;  4N7T A;  1AJC A;  2W8S A;  4MHX A;  4MIV A;  1ELY A;  1URA A;  3BDG A;  1EQJ A;  4TN0 A;  4ZGA A;  1ALJ A;  5LIA A;  3IDD A;  4CYS A;  1K7H A;  3OT9 A;  2GSU A;  2X98 A;  4UOO A;  1ELZ A;  1EJJ A;  2W5W A;  2W5X A;  4LRC A;  2W5R A;  3IGY B;  1ANI A;  4GTY A;  3BDF A;  3NVL A;  3M8Z A;  2G9Y A;  2XRG A;  1AJD A;  4CXK A;  5IJS A;  1KHJ A;  2IUC A;  1SHN A;  4GTW A;  3T01 A;  4KAV A;  1SHQ A;  4KM4 A;  2ANH A;  2W5S A;  3MK1 A;  3WAY A;  1ALH A;  2VQR A;  3A52 A;  5DLV A;  3M7V A;  4UOP A;  3BDH A;  3T02 A;  1ALK A;  4LRB A;  4LRA A;  3WAV A;  2XR9 A;  2GSO A;  1EI6 A;  3KD8 A;  4YR1 A;  3NKM A;  1EW2 A;  4LRE A;  4NWX A;  1KH7 A;  2W8D A;  4UPI A;  1P49 A;  1ZED A;  1ZEF A;  2RH6 A;  3LXQ A;  3UN5 A;  5L0K A;  2QZU A;  4KAY A;  4LQY A;  1HQA A;  5L0E A;  3DYC A;  3E2D A;  3NKR A;  4LR8 A;  2W5T A;  1ELX A;  2W5V A;  4UPH A;  1KHK A;  5KXA A;  3MK2 A;  3UNY A;  3NKO A;  4ZG9 A;  4ZG6 A;  2IFY A;  3CMR A;  5HRT A;  1ALI A;  2D1G A;  5INH A;  5EGH A;  4LR9 A;  2GSN A;  4UOR A;  1E2S P;  3BDG B;  1AJA A;  1E3C P;  4NWJ A;  1HDH A;  3T00 A; 
#chains in the Genus database with same CATH topology
 4GTZ A;  1HJK A;  3B5Q A;  4LR2 A;  3SZZ A;  3UO0 A;  3NKQ A;  3TX0 A;  3MK0 A;  4LR7 A;  4MY4 A;  1B8J A;  1O98 A;  2GLQ A;  2W5Q A;  3UN3 A;  4KJG A;  3NKP A;  2ZKT A;  3WAW A;  3SZY A;  1E33 P;  5L0B A;  4KJD A;  1AUK A;  1ED9 A;  5AJ9 A;  5EGE A;  3WBH A;  1URB A;  1KHL A;  1ZEB A;  3M8W A;  3WAX A;  1N2K A;  1FSU A;  4QAX A;  4CYR A;  1EW9 A;  4UPK A;  4UPL A;  3ED4 A;  5TJ3 A;  1Y7A A;  5K4P A;  2GA3 A;  1AJB A;  5GRR A;  3TG0 A;  5IJQ A;  1ED8 A;  3NKN A;  1Y6V A;  4CXS A;  3M8Y A;  3DPC A;  4FDI A;  1KHN A;  4ZG7 A;  1KH5 A;  1O99 A;  4B56 A;  1ANJ A;  3UN2 A;  5GOV A;  3IGZ B;  1E1Z P;  1EW8 A;  4CXU A;  5LRM A;  5LQQ A;  1KH9 A;  3TWZ A;  2IUC B;  1N2L A;  4FDJ A;  5DLW A;  5DLT A;  5LRN A;  1KH4 A;  4LRD A;  5C66 A;  4GTX A;  3Q3Q A;  4LRF A;  4N7T A;  1AJC A;  2W8S A;  4MHX A;  4MIV A;  1ELY A;  1URA A;  3BDG A;  1EQJ A;  4TN0 A;  4ZGA A;  1ALJ A;  5LIA A;  3IDD A;  4CYS A;  1K7H A;  3OT9 A;  2GSU A;  2X98 A;  4UOO A;  1ELZ A;  1EJJ A;  2W5W A;  2W5X A;  4LRC A;  2W5R A;  3IGY B;  1ANI A;  4GTY A;  3BDF A;  3NVL A;  3M8Z A;  2G9Y A;  2XRG A;  1AJD A;  4CXK A;  5IJS A;  1KHJ A;  2IUC A;  1SHN A;  4GTW A;  3T01 A;  4KAV A;  1SHQ A;  4KM4 A;  2ANH A;  2W5S A;  3MK1 A;  3WAY A;  1ALH A;  2VQR A;  3A52 A;  5DLV A;  3M7V A;  4UOP A;  3BDH A;  3T02 A;  1ALK A;  4LRB A;  4LRA A;  3WAV A;  2XR9 A;  2GSO A;  1EI6 A;  3KD8 A;  4YR1 A;  3NKM A;  1EW2 A;  4LRE A;  4NWX A;  1KH7 A;  2W8D A;  4UPI A;  1P49 A;  1ZED A;  1ZEF A;  2RH6 A;  3LXQ A;  3UN5 A;  5L0K A;  2QZU A;  4KAY A;  4LQY A;  1HQA A;  5L0E A;  3DYC A;  3E2D A;  3NKR A;  4LR8 A;  2W5T A;  1ELX A;  2W5V A;  4UPH A;  1KHK A;  5KXA A;  3MK2 A;  3UNY A;  3NKO A;  4ZG9 A;  4ZG6 A;  2IFY A;  3CMR A;  5HRT A;  1ALI A;  2D1G A;  5INH A;  5EGH A;  4LR9 A;  2GSN A;  4UOR A;  1E2S P;  3BDG B;  1AJA A;  1E3C P;  4NWJ A;  1HDH A;  3T00 A; 
#chains in the Genus database with same CATH homology
 4GTZ A;  1HJK A;  3B5Q A;  4LR2 A;  3SZZ A;  3UO0 A;  3NKQ A;  3TX0 A;  3MK0 A;  4LR7 A;  4MY4 A;  1B8J A;  1O98 A;  2GLQ A;  2W5Q A;  3UN3 A;  4KJG A;  3NKP A;  2ZKT A;  3WAW A;  3SZY A;  1E33 P;  5L0B A;  4KJD A;  1AUK A;  1ED9 A;  5AJ9 A;  5EGE A;  3WBH A;  1URB A;  1KHL A;  1ZEB A;  3M8W A;  3WAX A;  1N2K A;  1FSU A;  4QAX A;  4CYR A;  1EW9 A;  4UPK A;  4UPL A;  3ED4 A;  5TJ3 A;  1Y7A A;  5K4P A;  2GA3 A;  1AJB A;  5GRR A;  3TG0 A;  5IJQ A;  1ED8 A;  3NKN A;  1Y6V A;  4CXS A;  3M8Y A;  3DPC A;  4FDI A;  1KHN A;  4ZG7 A;  1KH5 A;  1O99 A;  4B56 A;  1ANJ A;  3UN2 A;  5GOV A;  3IGZ B;  1E1Z P;  1EW8 A;  4CXU A;  5LRM A;  5LQQ A;  1KH9 A;  3TWZ A;  2IUC B;  1N2L A;  4FDJ A;  5DLW A;  5DLT A;  5LRN A;  1KH4 A;  4LRD A;  5C66 A;  4GTX A;  3Q3Q A;  4LRF A;  4N7T A;  1AJC A;  2W8S A;  4MHX A;  4MIV A;  1ELY A;  1URA A;  3BDG A;  1EQJ A;  4TN0 A;  4ZGA A;  1ALJ A;  5LIA A;  3IDD A;  4CYS A;  1K7H A;  3OT9 A;  2GSU A;  2X98 A;  4UOO A;  1ELZ A;  1EJJ A;  2W5W A;  2W5X A;  4LRC A;  2W5R A;  3IGY B;  1ANI A;  4GTY A;  3BDF A;  3NVL A;  3M8Z A;  2G9Y A;  2XRG A;  1AJD A;  4CXK A;  5IJS A;  1KHJ A;  2IUC A;  1SHN A;  4GTW A;  3T01 A;  4KAV A;  1SHQ A;  4KM4 A;  2ANH A;  2W5S A;  3MK1 A;  3WAY A;  1ALH A;  2VQR A;  3A52 A;  5DLV A;  3M7V A;  4UOP A;  3BDH A;  3T02 A;  1ALK A;  4LRB A;  4LRA A;  3WAV A;  2XR9 A;  2GSO A;  1EI6 A;  3KD8 A;  4YR1 A;  3NKM A;  1EW2 A;  4LRE A;  4NWX A;  1KH7 A;  2W8D A;  4UPI A;  1P49 A;  1ZED A;  1ZEF A;  2RH6 A;  3LXQ A;  3UN5 A;  5L0K A;  2QZU A;  4KAY A;  4LQY A;  1HQA A;  5L0E A;  3DYC A;  3E2D A;  3NKR A;  4LR8 A;  2W5T A;  1ELX A;  2W5V A;  4UPH A;  1KHK A;  5KXA A;  3MK2 A;  3UNY A;  3NKO A;  4ZG9 A;  4ZG6 A;  2IFY A;  3CMR A;  5HRT A;  1ALI A;  2D1G A;  5INH A;  5EGH A;  4LR9 A;  2GSN A;  4UOR A;  1E2S P;  3BDG B;  1AJA A;  1E3C P;  4NWJ A;  1HDH A;  3T00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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