2W5VA

Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site.
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords ALKALINE PHOSPHATASE
publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
molecule tags Hydrolase
total genus 128
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5vA00
3UN2A 5L0BA 1N2KA 2W5XA 4LRDA 5DLWA 3IGZB 4KJDA 4NWJA 2IFYA 2VQRA 3M8ZA 2W5RA 2W5WA 3UO0A 2W5SA 1KH5A 2XRGA 4UPHA 4B56A 3TG0A 1ELYA 1ANJA 1SHQA 1EW2A 4FDJA 1AJDA 1ALKA 3WAXA 3NKQA 1Y7AA 4ZG9A 4MIVA 3UNYA 3DPCA 5TJ3A 3MK0A 4GTZA 1P49A 5EGHA 1HDHA 3T02A 1ALIA 4KAVA 5K4PA 3NKMA 1URBA 2GLQA 5DLTA 1KHLA 1AUKA 5GRRA 1B8JA 3DYCA 4N7TA 5KXAA 1ELZA 5LQQA 1SHNA 4NWXA 2IUCB 1KH7A 3TX0A 3BDFA 2GA3A 1EJJA 4CXSA 1O98A 4CYRA 1URAA 4CXUA 4GTXA 4LRFA 1E1ZP 4GTYA 1ALHA 1ZEBA 1ANIA 1ELXA 4MY4A 1HQAA 4UPIA 1AJCA 1KH9A 4ZGAA 4CYSA 5GOVA 4KM4A 2X98A 2ANHA 3SZYA 5LRNA 5INHA 3B5QA 3BDHA 1ED8A 5AJ9A 3MK1A 4UOOA 2XR9A 3WAVA 2W5TA 5IJSA 1AJBA 4LREA 1ZEFA 1N2LA 1Y6VA 3OT9A 3UN3A 1E2SP 3NKOA 3SZZA 3M7VA 3KD8A 4KJGA 4LRCA 4GTWA 3A52A 3BDGA 1O99A 3LXQA 5C66A 4LR9A 4QAXA 1AJAA 3NKNA 2W8SA 3IGYB 1KHJA 4UOPA 3WBHA 4LR2A 4LR7A 3NVLA 3Q3QA 4ZG6A 4CXKA 1KH4A 1EW8A 4MHXA 2G9YA 2W8DA 5DLVA 1K7HA 5LRMA 1E3CP 1ALJA 3IDDA 3ED4A 3T00A 3UN5A 2QZUA 1FSUA 4UPKA 4KAYA 2W5QA 2W5VA 3M8YA 2GSNA 1HJKA 3WAWA 1EW9A 1EQJA 3M8WA 3MK2A 4LRAA 1EI6A 4LR8A 5IJQA 1KHNA 2GSOA 5L0KA 2GSUA 5LIAA 5EGEA 3CMRA 5HRTA 5L0EA 3NKRA 4YR1A 1E33P 3T01A 3NKPA 4LQYA 3E2DA 4FDIA 4ZG7A 1ED9A 3BDGB 3WAYA 2D1GA 4TN0A 1KHKA 4UORA 1ZEDA 4LRBA 4UPLA 2IUCA 3TWZA 2RH6A 2ZKTA
chains in the Genus database with same CATH superfamily
3UN2A 5L0BA 1N2KA 2W5XA 4LRDA 5DLWA 3IGZB 4KJDA 4NWJA 2IFYA 2VQRA 3M8ZA 2W5RA 2W5WA 3UO0A 2W5SA 1KH5A 2XRGA 4UPHA 4B56A 3TG0A 1ELYA 1ANJA 1SHQA 1EW2A 4FDJA 1AJDA 1ALKA 3WAXA 3NKQA 1Y7AA 4ZG9A 4MIVA 3UNYA 3DPCA 5TJ3A 3MK0A 4GTZA 1P49A 5EGHA 1HDHA 3T02A 1ALIA 4KAVA 5K4PA 3NKMA 1URBA 2GLQA 5DLTA 1KHLA 1AUKA 5GRRA 1B8JA 3DYCA 4N7TA 5KXAA 1ELZA 5LQQA 1SHNA 4NWXA 2IUCB 1KH7A 3TX0A 3BDFA 2GA3A 1EJJA 4CXSA 1O98A 4CYRA 1URAA 4CXUA 4GTXA 4LRFA 1E1ZP 4GTYA 1ALHA 1ZEBA 1ANIA 1ELXA 4MY4A 1HQAA 4UPIA 1AJCA 1KH9A 4ZGAA 4CYSA 5GOVA 4KM4A 2X98A 2ANHA 3SZYA 5LRNA 5INHA 3B5QA 3BDHA 1ED8A 5AJ9A 3MK1A 4UOOA 2XR9A 3WAVA 2W5TA 5IJSA 1AJBA 4LREA 1ZEFA 1N2LA 1Y6VA 3OT9A 3UN3A 1E2SP 3NKOA 3SZZA 3M7VA 3KD8A 4KJGA 4LRCA 4GTWA 3A52A 3BDGA 1O99A 3LXQA 5C66A 4LR9A 4QAXA 1AJAA 3NKNA 2W8SA 3IGYB 1KHJA 4UOPA 3WBHA 4LR2A 4LR7A 3NVLA 3Q3QA 4ZG6A 4CXKA 1KH4A 1EW8A 4MHXA 2G9YA 2W8DA 5DLVA 1K7HA 5LRMA 1E3CP 1ALJA 3IDDA 3ED4A 3T00A 3UN5A 2QZUA 1FSUA 4UPKA 4KAYA 2W5QA 2W5VA 3M8YA 2GSNA 1HJKA 3WAWA 1EW9A 1EQJA 3M8WA 3MK2A 4LRAA 1EI6A 4LR8A 5IJQA 1KHNA 2GSOA 5L0KA 2GSUA 5LIAA 5EGEA 3CMRA 5HRTA 5L0EA 3NKRA 4YR1A 1E33P 3T01A 3NKPA 4LQYA 3E2DA 4FDIA 4ZG7A 1ED9A 3BDGB 3WAYA 2D1GA 4TN0A 1KHKA 4UORA 1ZEDA 4LRBA 4UPLA 2IUCA 3TWZA 2RH6A 2ZKTA
chains in the Genus database with same CATH topology
3UN2A 5L0BA 1N2KA 2W5XA 4LRDA 5DLWA 3IGZB 4KJDA 4NWJA 2IFYA 2VQRA 3M8ZA 2W5RA 2W5WA 3UO0A 2W5SA 1KH5A 2XRGA 4UPHA 4B56A 3TG0A 1ELYA 1ANJA 1SHQA 1EW2A 4FDJA 1AJDA 1ALKA 3WAXA 3NKQA 1Y7AA 4ZG9A 4MIVA 3UNYA 3DPCA 5TJ3A 3MK0A 4GTZA 1P49A 5EGHA 1HDHA 3T02A 1ALIA 4KAVA 5K4PA 3NKMA 1URBA 2GLQA 5DLTA 1KHLA 1AUKA 5GRRA 1B8JA 3DYCA 4N7TA 5KXAA 1ELZA 5LQQA 1SHNA 4NWXA 2IUCB 1KH7A 3TX0A 3BDFA 2GA3A 1EJJA 4CXSA 1O98A 4CYRA 1URAA 4CXUA 4GTXA 4LRFA 1E1ZP 4GTYA 1ALHA 1ZEBA 1ANIA 1ELXA 4MY4A 1HQAA 4UPIA 1AJCA 1KH9A 4ZGAA 4CYSA 5GOVA 4KM4A 2X98A 2ANHA 3SZYA 5LRNA 5INHA 3B5QA 3BDHA 1ED8A 5AJ9A 3MK1A 4UOOA 2XR9A 3WAVA 2W5TA 5IJSA 1AJBA 4LREA 1ZEFA 1N2LA 1Y6VA 3OT9A 3UN3A 1E2SP 3NKOA 3SZZA 3M7VA 3KD8A 4KJGA 4LRCA 4GTWA 3A52A 3BDGA 1O99A 3LXQA 5C66A 4LR9A 4QAXA 1AJAA 3NKNA 2W8SA 3IGYB 1KHJA 4UOPA 3WBHA 4LR2A 4LR7A 3NVLA 3Q3QA 4ZG6A 4CXKA 1KH4A 1EW8A 4MHXA 2G9YA 2W8DA 5DLVA 1K7HA 5LRMA 1E3CP 1ALJA 3IDDA 3ED4A 3T00A 3UN5A 2QZUA 1FSUA 4UPKA 4KAYA 2W5QA 2W5VA 3M8YA 2GSNA 1HJKA 3WAWA 1EW9A 1EQJA 3M8WA 3MK2A 4LRAA 1EI6A 4LR8A 5IJQA 1KHNA 2GSOA 5L0KA 2GSUA 5LIAA 5EGEA 3CMRA 5HRTA 5L0EA 3NKRA 4YR1A 1E33P 3T01A 3NKPA 4LQYA 3E2DA 4FDIA 4ZG7A 1ED9A 3BDGB 3WAYA 2D1GA 4TN0A 1KHKA 4UORA 1ZEDA 4LRBA 4UPLA 2IUCA 3TWZA 2RH6A 2ZKTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3UN2 A;  5L0B A;  1N2K A;  2W5X A;  4LRD A;  5DLW A;  3IGZ B;  4KJD A;  4NWJ A;  2IFY A;  2VQR A;  3M8Z A;  2W5R A;  2W5W A;  3UO0 A;  2W5S A;  1KH5 A;  2XRG A;  4UPH A;  4B56 A;  3TG0 A;  1ELY A;  1ANJ A;  1SHQ A;  1EW2 A;  4FDJ A;  1AJD A;  1ALK A;  3WAX A;  3NKQ A;  1Y7A A;  4ZG9 A;  4MIV A;  3UNY A;  3DPC A;  5TJ3 A;  3MK0 A;  4GTZ A;  1P49 A;  5EGH A;  1HDH A;  3T02 A;  1ALI A;  4KAV A;  5K4P A;  3NKM A;  1URB A;  2GLQ A;  5DLT A;  1KHL A;  1AUK A;  5GRR A;  1B8J A;  3DYC A;  4N7T A;  5KXA A;  1ELZ A;  5LQQ A;  1SHN A;  4NWX A;  2IUC B;  1KH7 A;  3TX0 A;  3BDF A;  2GA3 A;  1EJJ A;  4CXS A;  1O98 A;  4CYR A;  1URA A;  4CXU A;  4GTX A;  4LRF A;  1E1Z P;  4GTY A;  1ALH A;  1ZEB A;  1ANI A;  1ELX A;  4MY4 A;  1HQA A;  4UPI A;  1AJC A;  1KH9 A;  4ZGA A;  4CYS A;  5GOV A;  4KM4 A;  2X98 A;  2ANH A;  3SZY A;  5LRN A;  5INH A;  3B5Q A;  3BDH A;  1ED8 A;  5AJ9 A;  3MK1 A;  4UOO A;  2XR9 A;  3WAV A;  2W5T A;  5IJS A;  1AJB A;  4LRE A;  1ZEF A;  1N2L A;  1Y6V A;  3OT9 A;  3UN3 A;  1E2S P;  3NKO A;  3SZZ A;  3M7V A;  3KD8 A;  4KJG A;  4LRC A;  4GTW A;  3A52 A;  3BDG A;  1O99 A;  3LXQ A;  5C66 A;  4LR9 A;  4QAX A;  1AJA A;  3NKN A;  2W8S A;  3IGY B;  1KHJ A;  4UOP A;  3WBH A;  4LR2 A;  4LR7 A;  3NVL A;  3Q3Q A;  4ZG6 A;  4CXK A;  1KH4 A;  1EW8 A;  4MHX A;  2G9Y A;  2W8D A;  5DLV A;  1K7H A;  5LRM A;  1E3C P;  1ALJ A;  3IDD A;  3ED4 A;  3T00 A;  3UN5 A;  2QZU A;  1FSU A;  4UPK A;  4KAY A;  2W5Q A;  2W5V A;  3M8Y A;  2GSN A;  1HJK A;  3WAW A;  1EW9 A;  1EQJ A;  3M8W A;  3MK2 A;  4LRA A;  1EI6 A;  4LR8 A;  5IJQ A;  1KHN A;  2GSO A;  5L0K A;  2GSU A;  5LIA A;  5EGE A;  3CMR A;  5HRT A;  5L0E A;  3NKR A;  4YR1 A;  1E33 P;  3T01 A;  3NKP A;  4LQY A;  3E2D A;  4FDI A;  4ZG7 A;  1ED9 A;  3BDG B;  3WAY A;  2D1G A;  4TN0 A;  1KHK A;  4UOR A;  1ZED A;  4LRB A;  4UPL A;  2IUC A;  3TWZ A;  2RH6 A;  2ZKT A; 
#chains in the Genus database with same CATH topology
 3UN2 A;  5L0B A;  1N2K A;  2W5X A;  4LRD A;  5DLW A;  3IGZ B;  4KJD A;  4NWJ A;  2IFY A;  2VQR A;  3M8Z A;  2W5R A;  2W5W A;  3UO0 A;  2W5S A;  1KH5 A;  2XRG A;  4UPH A;  4B56 A;  3TG0 A;  1ELY A;  1ANJ A;  1SHQ A;  1EW2 A;  4FDJ A;  1AJD A;  1ALK A;  3WAX A;  3NKQ A;  1Y7A A;  4ZG9 A;  4MIV A;  3UNY A;  3DPC A;  5TJ3 A;  3MK0 A;  4GTZ A;  1P49 A;  5EGH A;  1HDH A;  3T02 A;  1ALI A;  4KAV A;  5K4P A;  3NKM A;  1URB A;  2GLQ A;  5DLT A;  1KHL A;  1AUK A;  5GRR A;  1B8J A;  3DYC A;  4N7T A;  5KXA A;  1ELZ A;  5LQQ A;  1SHN A;  4NWX A;  2IUC B;  1KH7 A;  3TX0 A;  3BDF A;  2GA3 A;  1EJJ A;  4CXS A;  1O98 A;  4CYR A;  1URA A;  4CXU A;  4GTX A;  4LRF A;  1E1Z P;  4GTY A;  1ALH A;  1ZEB A;  1ANI A;  1ELX A;  4MY4 A;  1HQA A;  4UPI A;  1AJC A;  1KH9 A;  4ZGA A;  4CYS A;  5GOV A;  4KM4 A;  2X98 A;  2ANH A;  3SZY A;  5LRN A;  5INH A;  3B5Q A;  3BDH A;  1ED8 A;  5AJ9 A;  3MK1 A;  4UOO A;  2XR9 A;  3WAV A;  2W5T A;  5IJS A;  1AJB A;  4LRE A;  1ZEF A;  1N2L A;  1Y6V A;  3OT9 A;  3UN3 A;  1E2S P;  3NKO A;  3SZZ A;  3M7V A;  3KD8 A;  4KJG A;  4LRC A;  4GTW A;  3A52 A;  3BDG A;  1O99 A;  3LXQ A;  5C66 A;  4LR9 A;  4QAX A;  1AJA A;  3NKN A;  2W8S A;  3IGY B;  1KHJ A;  4UOP A;  3WBH A;  4LR2 A;  4LR7 A;  3NVL A;  3Q3Q A;  4ZG6 A;  4CXK A;  1KH4 A;  1EW8 A;  4MHX A;  2G9Y A;  2W8D A;  5DLV A;  1K7H A;  5LRM A;  1E3C P;  1ALJ A;  3IDD A;  3ED4 A;  3T00 A;  3UN5 A;  2QZU A;  1FSU A;  4UPK A;  4KAY A;  2W5Q A;  2W5V A;  3M8Y A;  2GSN A;  1HJK A;  3WAW A;  1EW9 A;  1EQJ A;  3M8W A;  3MK2 A;  4LRA A;  1EI6 A;  4LR8 A;  5IJQ A;  1KHN A;  2GSO A;  5L0K A;  2GSU A;  5LIA A;  5EGE A;  3CMR A;  5HRT A;  5L0E A;  3NKR A;  4YR1 A;  1E33 P;  3T01 A;  3NKP A;  4LQY A;  3E2D A;  4FDI A;  4ZG7 A;  1ED9 A;  3BDG B;  3WAY A;  2D1G A;  4TN0 A;  1KHK A;  4UOR A;  1ZED A;  4LRB A;  4UPL A;  2IUC A;  3TWZ A;  2RH6 A;  2ZKT A; 
#chains in the Genus database with same CATH homology
 3UN2 A;  5L0B A;  1N2K A;  2W5X A;  4LRD A;  5DLW A;  3IGZ B;  4KJD A;  4NWJ A;  2IFY A;  2VQR A;  3M8Z A;  2W5R A;  2W5W A;  3UO0 A;  2W5S A;  1KH5 A;  2XRG A;  4UPH A;  4B56 A;  3TG0 A;  1ELY A;  1ANJ A;  1SHQ A;  1EW2 A;  4FDJ A;  1AJD A;  1ALK A;  3WAX A;  3NKQ A;  1Y7A A;  4ZG9 A;  4MIV A;  3UNY A;  3DPC A;  5TJ3 A;  3MK0 A;  4GTZ A;  1P49 A;  5EGH A;  1HDH A;  3T02 A;  1ALI A;  4KAV A;  5K4P A;  3NKM A;  1URB A;  2GLQ A;  5DLT A;  1KHL A;  1AUK A;  5GRR A;  1B8J A;  3DYC A;  4N7T A;  5KXA A;  1ELZ A;  5LQQ A;  1SHN A;  4NWX A;  2IUC B;  1KH7 A;  3TX0 A;  3BDF A;  2GA3 A;  1EJJ A;  4CXS A;  1O98 A;  4CYR A;  1URA A;  4CXU A;  4GTX A;  4LRF A;  1E1Z P;  4GTY A;  1ALH A;  1ZEB A;  1ANI A;  1ELX A;  4MY4 A;  1HQA A;  4UPI A;  1AJC A;  1KH9 A;  4ZGA A;  4CYS A;  5GOV A;  4KM4 A;  2X98 A;  2ANH A;  3SZY A;  5LRN A;  5INH A;  3B5Q A;  3BDH A;  1ED8 A;  5AJ9 A;  3MK1 A;  4UOO A;  2XR9 A;  3WAV A;  2W5T A;  5IJS A;  1AJB A;  4LRE A;  1ZEF A;  1N2L A;  1Y6V A;  3OT9 A;  3UN3 A;  1E2S P;  3NKO A;  3SZZ A;  3M7V A;  3KD8 A;  4KJG A;  4LRC A;  4GTW A;  3A52 A;  3BDG A;  1O99 A;  3LXQ A;  5C66 A;  4LR9 A;  4QAX A;  1AJA A;  3NKN A;  2W8S A;  3IGY B;  1KHJ A;  4UOP A;  3WBH A;  4LR2 A;  4LR7 A;  3NVL A;  3Q3Q A;  4ZG6 A;  4CXK A;  1KH4 A;  1EW8 A;  4MHX A;  2G9Y A;  2W8D A;  5DLV A;  1K7H A;  5LRM A;  1E3C P;  1ALJ A;  3IDD A;  3ED4 A;  3T00 A;  3UN5 A;  2QZU A;  1FSU A;  4UPK A;  4KAY A;  2W5Q A;  2W5V A;  3M8Y A;  2GSN A;  1HJK A;  3WAW A;  1EW9 A;  1EQJ A;  3M8W A;  3MK2 A;  4LRA A;  1EI6 A;  4LR8 A;  5IJQ A;  1KHN A;  2GSO A;  5L0K A;  2GSU A;  5LIA A;  5EGE A;  3CMR A;  5HRT A;  5L0E A;  3NKR A;  4YR1 A;  1E33 P;  3T01 A;  3NKP A;  4LQY A;  3E2D A;  4FDI A;  4ZG7 A;  1ED9 A;  3BDG B;  3WAY A;  2D1G A;  4TN0 A;  1KHK A;  4UOR A;  1ZED A;  4LRB A;  4UPL A;  2IUC A;  3TWZ A;  2RH6 A;  2ZKT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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