2W5VA

Structure of tab5 alkaline phosphatase mutant his 135 asp with mg bound in the m3 site.
Total Genus 128
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
128
Knots found
sequence length
346
structure length
345
Chain Sequence
QLKTPKNVILLISDGAGLSQISSTFYFKSGTPNYTQFKNIGLIKTSSSREDVTDASGATAFSCGIKTYNAAIGVADDSTAVKSIVEIAALNNIKTGVVATSSITDATPASFYAHALNRGLEEEIAMDMTESDLDFFAGGGLNYFTKRKDKKDVLAILKGNQFTINTTALTDFSSIASNRKMGFLLADEAMPTMEKGRGNFLSAATDLAIQFLSKDNSAFFIMSEGSQIDWGGHANNASYLISEINDFDDAIGTALAFAKKDGNTLVIVTSDHETGGFTLAAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPGSEEFIGIYENNEIFHKILKVTKWNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Coordination Sphere of the Third Metal Site is Essential to the Activity and Metal Selectivity of Alkaline Phosphatases.
pubmed doi rcsb
source organism Antarctic bacterium tab5
total genus 128
structure length 345
sequence length 346
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-12-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 2w5vA00
1ED8A 4KJGA 2W5QA 3LXQA 3T02A 4LRCA 1EQJA 2RH6A 4LR8A 1ED9A 1ALIA 4UPIA 3UN3A 3BDHA 1E33P 4GTWA 4N7TA 3WBHA 2W5WA 2W5XA 1Y7AA 4LRDA 2W5SA 4UPHA 5L0KA 3TX0A 3M7VA 4LR9A 3KD8A 4ZG9A 5AJ9A 5LRNA 3BDGB 5EGHA 3E2DA 2XR9A 4KAYA 4LREA 5K4PA 1SHNA 4ZG6A 4UOOA 5KXAA 5L0BA 3MK1A 3NKNA 1FSUA 3IGYB 4CXKA 5IJSA 3M8ZA 4ZG7A 2IUCB 4CXSA 1E3CP 1EW2A 5INHA 1KH4A 4YR1A 4KAVA 4CYRA 1HJKA 1ALHA 1ALJA 4UPLA 1O99A 2ANHA 5TJ3A 4UPKA 3A52A 3T00A 1KHJA 2W8DA 3NKOA 5GOVA 5HRTA 4UORA 4GTXA 2W5TA 3M8WA 4MY4A 2GSUA 1KHKA 3DYCA 3NKPA 1URBA 2D1GA 1ELXA 2W8SA 1EJJA 3ED4A 3M8YA 1E2SP 1ANIA 1KH9A 2XRGA 3B5QA 1EW8A 4KJDA 4MHXA 1Y6VA 1SHQA 1N2LA 4QAXA 3UN5A 4LQYA 1HDHA 5DLWA 1KH5A 3UO0A 2GA3A 4LRFA 1KH7A 3MK0A 1KHNA 2W5VA 4LRBA 3UNYA 3MK2A 5LIAA 2GLQA 3WAXA 3UN2A 1ALKA 1B8JA 4GTYA 5IJQA 3IGZB 3T01A 5EGEA 3OT9A 1HQAA 5LRMA 1AJAA 1AJDA 1K7HA 2ZKTA 1EW9A 4TN0A 1AJCA 3DPCA 3NVLA 1P49A 4CYSA 4FDIA 1ZEDA 3NKMA 3Q3QA 4LR7A 3WAVA 1N2KA 4GTZA 4LRAA 1ELYA 4MIVA 3SZYA 4B56A 1E1ZP 3BDGA 1KHLA 3CMRA 2GSNA 1URAA 2VQRA 3BDFA 4NWXA 5LQQA 2W5RA 3NKQA 1ZEBA 3WAYA 2GSOA 5DLTA 2IUCA 1AUKA 5C66A 4CXUA 2X98A 2G9YA 5L0EA 4NWJA 3SZZA 3TWZA 2IFYA 4KM4A 2QZUA 3NKRA 5DLVA 1ANJA 4UOPA 3TG0A 3WAWA 1ELZA 1EI6A 1AJBA 1O98A 1ZEFA 4FDJA 5GRRA 4ZGAA 3IDDA 4LR2A
chains in the Genus database with same CATH superfamily
1ED8A 4KJGA 2W5QA 3LXQA 3T02A 4LRCA 1EQJA 2RH6A 4LR8A 1ED9A 1ALIA 4UPIA 3UN3A 3BDHA 1E33P 4GTWA 4N7TA 3WBHA 2W5WA 2W5XA 1Y7AA 4LRDA 2W5SA 4UPHA 5L0KA 3TX0A 3M7VA 4LR9A 3KD8A 4ZG9A 5AJ9A 5LRNA 3BDGB 5EGHA 3E2DA 2XR9A 4KAYA 4LREA 5K4PA 1SHNA 4ZG6A 4UOOA 5KXAA 5L0BA 3MK1A 3NKNA 1FSUA 3IGYB 4CXKA 5IJSA 3M8ZA 4ZG7A 2IUCB 4CXSA 1E3CP 1EW2A 5INHA 1KH4A 4YR1A 4KAVA 4CYRA 1HJKA 1ALHA 1ALJA 4UPLA 1O99A 2ANHA 5TJ3A 4UPKA 3A52A 3T00A 1KHJA 2W8DA 3NKOA 5GOVA 5HRTA 4UORA 4GTXA 2W5TA 3M8WA 4MY4A 2GSUA 1KHKA 3DYCA 3NKPA 1URBA 2D1GA 1ELXA 2W8SA 1EJJA 3ED4A 3M8YA 1E2SP 1ANIA 1KH9A 2XRGA 3B5QA 1EW8A 4KJDA 4MHXA 1Y6VA 1SHQA 1N2LA 4QAXA 3UN5A 4LQYA 1HDHA 5DLWA 1KH5A 3UO0A 2GA3A 4LRFA 1KH7A 3MK0A 1KHNA 2W5VA 4LRBA 3UNYA 3MK2A 5LIAA 2GLQA 3WAXA 3UN2A 1ALKA 1B8JA 4GTYA 5IJQA 3IGZB 3T01A 5EGEA 3OT9A 1HQAA 5LRMA 1AJAA 1AJDA 1K7HA 2ZKTA 1EW9A 4TN0A 1AJCA 3DPCA 3NVLA 1P49A 4CYSA 4FDIA 1ZEDA 3NKMA 3Q3QA 4LR7A 3WAVA 1N2KA 4GTZA 4LRAA 1ELYA 4MIVA 3SZYA 4B56A 1E1ZP 3BDGA 1KHLA 3CMRA 2GSNA 1URAA 2VQRA 3BDFA 4NWXA 5LQQA 2W5RA 3NKQA 1ZEBA 3WAYA 2GSOA 5DLTA 2IUCA 1AUKA 5C66A 4CXUA 2X98A 2G9YA 5L0EA 4NWJA 3SZZA 3TWZA 2IFYA 4KM4A 2QZUA 3NKRA 5DLVA 1ANJA 4UOPA 3TG0A 3WAWA 1ELZA 1EI6A 1AJBA 1O98A 1ZEFA 4FDJA 5GRRA 4ZGAA 3IDDA 4LR2A
chains in the Genus database with same CATH topology
1ED8A 4KJGA 2W5QA 3LXQA 3T02A 4LRCA 1EQJA 2RH6A 4LR8A 1ED9A 1ALIA 4UPIA 3UN3A 3BDHA 1E33P 4GTWA 4N7TA 3WBHA 2W5WA 2W5XA 1Y7AA 4LRDA 2W5SA 4UPHA 5L0KA 3TX0A 3M7VA 4LR9A 3KD8A 4ZG9A 5AJ9A 5LRNA 3BDGB 5EGHA 3E2DA 2XR9A 4KAYA 4LREA 5K4PA 1SHNA 4ZG6A 4UOOA 5KXAA 5L0BA 3MK1A 3NKNA 1FSUA 3IGYB 4CXKA 5IJSA 3M8ZA 4ZG7A 2IUCB 4CXSA 1E3CP 1EW2A 5INHA 1KH4A 4YR1A 4KAVA 4CYRA 1HJKA 1ALHA 1ALJA 4UPLA 1O99A 2ANHA 5TJ3A 4UPKA 3A52A 3T00A 1KHJA 2W8DA 3NKOA 5GOVA 5HRTA 4UORA 4GTXA 2W5TA 3M8WA 4MY4A 2GSUA 1KHKA 3DYCA 3NKPA 1URBA 2D1GA 1ELXA 2W8SA 1EJJA 3ED4A 3M8YA 1E2SP 1ANIA 1KH9A 2XRGA 3B5QA 1EW8A 4KJDA 4MHXA 1Y6VA 1SHQA 1N2LA 4QAXA 3UN5A 4LQYA 1HDHA 5DLWA 1KH5A 3UO0A 2GA3A 4LRFA 1KH7A 3MK0A 1KHNA 2W5VA 4LRBA 3UNYA 3MK2A 5LIAA 2GLQA 3WAXA 3UN2A 1ALKA 1B8JA 4GTYA 5IJQA 3IGZB 3T01A 5EGEA 3OT9A 1HQAA 5LRMA 1AJAA 1AJDA 1K7HA 2ZKTA 1EW9A 4TN0A 1AJCA 3DPCA 3NVLA 1P49A 4CYSA 4FDIA 1ZEDA 3NKMA 3Q3QA 4LR7A 3WAVA 1N2KA 4GTZA 4LRAA 1ELYA 4MIVA 3SZYA 4B56A 1E1ZP 3BDGA 1KHLA 3CMRA 2GSNA 1URAA 2VQRA 3BDFA 4NWXA 5LQQA 2W5RA 3NKQA 1ZEBA 3WAYA 2GSOA 5DLTA 2IUCA 1AUKA 5C66A 4CXUA 2X98A 2G9YA 5L0EA 4NWJA 3SZZA 3TWZA 2IFYA 4KM4A 2QZUA 3NKRA 5DLVA 1ANJA 4UOPA 3TG0A 3WAWA 1ELZA 1EI6A 1AJBA 1O98A 1ZEFA 4FDJA 5GRRA 4ZGAA 3IDDA 4LR2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ED8 A;  4KJG A;  2W5Q A;  3LXQ A;  3T02 A;  4LRC A;  1EQJ A;  2RH6 A;  4LR8 A;  1ED9 A;  1ALI A;  4UPI A;  3UN3 A;  3BDH A;  1E33 P;  4GTW A;  4N7T A;  3WBH A;  2W5W A;  2W5X A;  1Y7A A;  4LRD A;  2W5S A;  4UPH A;  5L0K A;  3TX0 A;  3M7V A;  4LR9 A;  3KD8 A;  4ZG9 A;  5AJ9 A;  5LRN A;  3BDG B;  5EGH A;  3E2D A;  2XR9 A;  4KAY A;  4LRE A;  5K4P A;  1SHN A;  4ZG6 A;  4UOO A;  5KXA A;  5L0B A;  3MK1 A;  3NKN A;  1FSU A;  3IGY B;  4CXK A;  5IJS A;  3M8Z A;  4ZG7 A;  2IUC B;  4CXS A;  1E3C P;  1EW2 A;  5INH A;  1KH4 A;  4YR1 A;  4KAV A;  4CYR A;  1HJK A;  1ALH A;  1ALJ A;  4UPL A;  1O99 A;  2ANH A;  5TJ3 A;  4UPK A;  3A52 A;  3T00 A;  1KHJ A;  2W8D A;  3NKO A;  5GOV A;  5HRT A;  4UOR A;  4GTX A;  2W5T A;  3M8W A;  4MY4 A;  2GSU A;  1KHK A;  3DYC A;  3NKP A;  1URB A;  2D1G A;  1ELX A;  2W8S A;  1EJJ A;  3ED4 A;  3M8Y A;  1E2S P;  1ANI A;  1KH9 A;  2XRG A;  3B5Q A;  1EW8 A;  4KJD A;  4MHX A;  1Y6V A;  1SHQ A;  1N2L A;  4QAX A;  3UN5 A;  4LQY A;  1HDH A;  5DLW A;  1KH5 A;  3UO0 A;  2GA3 A;  4LRF A;  1KH7 A;  3MK0 A;  1KHN A;  2W5V A;  4LRB A;  3UNY A;  3MK2 A;  5LIA A;  2GLQ A;  3WAX A;  3UN2 A;  1ALK A;  1B8J A;  4GTY A;  5IJQ A;  3IGZ B;  3T01 A;  5EGE A;  3OT9 A;  1HQA A;  5LRM A;  1AJA A;  1AJD A;  1K7H A;  2ZKT A;  1EW9 A;  4TN0 A;  1AJC A;  3DPC A;  3NVL A;  1P49 A;  4CYS A;  4FDI A;  1ZED A;  3NKM A;  3Q3Q A;  4LR7 A;  3WAV A;  1N2K A;  4GTZ A;  4LRA A;  1ELY A;  4MIV A;  3SZY A;  4B56 A;  1E1Z P;  3BDG A;  1KHL A;  3CMR A;  2GSN A;  1URA A;  2VQR A;  3BDF A;  4NWX A;  5LQQ A;  2W5R A;  3NKQ A;  1ZEB A;  3WAY A;  2GSO A;  5DLT A;  2IUC A;  1AUK A;  5C66 A;  4CXU A;  2X98 A;  2G9Y A;  5L0E A;  4NWJ A;  3SZZ A;  3TWZ A;  2IFY A;  4KM4 A;  2QZU A;  3NKR A;  5DLV A;  1ANJ A;  4UOP A;  3TG0 A;  3WAW A;  1ELZ A;  1EI6 A;  1AJB A;  1O98 A;  1ZEF A;  4FDJ A;  5GRR A;  4ZGA A;  3IDD A;  4LR2 A; 
#chains in the Genus database with same CATH topology
 1ED8 A;  4KJG A;  2W5Q A;  3LXQ A;  3T02 A;  4LRC A;  1EQJ A;  2RH6 A;  4LR8 A;  1ED9 A;  1ALI A;  4UPI A;  3UN3 A;  3BDH A;  1E33 P;  4GTW A;  4N7T A;  3WBH A;  2W5W A;  2W5X A;  1Y7A A;  4LRD A;  2W5S A;  4UPH A;  5L0K A;  3TX0 A;  3M7V A;  4LR9 A;  3KD8 A;  4ZG9 A;  5AJ9 A;  5LRN A;  3BDG B;  5EGH A;  3E2D A;  2XR9 A;  4KAY A;  4LRE A;  5K4P A;  1SHN A;  4ZG6 A;  4UOO A;  5KXA A;  5L0B A;  3MK1 A;  3NKN A;  1FSU A;  3IGY B;  4CXK A;  5IJS A;  3M8Z A;  4ZG7 A;  2IUC B;  4CXS A;  1E3C P;  1EW2 A;  5INH A;  1KH4 A;  4YR1 A;  4KAV A;  4CYR A;  1HJK A;  1ALH A;  1ALJ A;  4UPL A;  1O99 A;  2ANH A;  5TJ3 A;  4UPK A;  3A52 A;  3T00 A;  1KHJ A;  2W8D A;  3NKO A;  5GOV A;  5HRT A;  4UOR A;  4GTX A;  2W5T A;  3M8W A;  4MY4 A;  2GSU A;  1KHK A;  3DYC A;  3NKP A;  1URB A;  2D1G A;  1ELX A;  2W8S A;  1EJJ A;  3ED4 A;  3M8Y A;  1E2S P;  1ANI A;  1KH9 A;  2XRG A;  3B5Q A;  1EW8 A;  4KJD A;  4MHX A;  1Y6V A;  1SHQ A;  1N2L A;  4QAX A;  3UN5 A;  4LQY A;  1HDH A;  5DLW A;  1KH5 A;  3UO0 A;  2GA3 A;  4LRF A;  1KH7 A;  3MK0 A;  1KHN A;  2W5V A;  4LRB A;  3UNY A;  3MK2 A;  5LIA A;  2GLQ A;  3WAX A;  3UN2 A;  1ALK A;  1B8J A;  4GTY A;  5IJQ A;  3IGZ B;  3T01 A;  5EGE A;  3OT9 A;  1HQA A;  5LRM A;  1AJA A;  1AJD A;  1K7H A;  2ZKT A;  1EW9 A;  4TN0 A;  1AJC A;  3DPC A;  3NVL A;  1P49 A;  4CYS A;  4FDI A;  1ZED A;  3NKM A;  3Q3Q A;  4LR7 A;  3WAV A;  1N2K A;  4GTZ A;  4LRA A;  1ELY A;  4MIV A;  3SZY A;  4B56 A;  1E1Z P;  3BDG A;  1KHL A;  3CMR A;  2GSN A;  1URA A;  2VQR A;  3BDF A;  4NWX A;  5LQQ A;  2W5R A;  3NKQ A;  1ZEB A;  3WAY A;  2GSO A;  5DLT A;  2IUC A;  1AUK A;  5C66 A;  4CXU A;  2X98 A;  2G9Y A;  5L0E A;  4NWJ A;  3SZZ A;  3TWZ A;  2IFY A;  4KM4 A;  2QZU A;  3NKR A;  5DLV A;  1ANJ A;  4UOP A;  3TG0 A;  3WAW A;  1ELZ A;  1EI6 A;  1AJB A;  1O98 A;  1ZEF A;  4FDJ A;  5GRR A;  4ZGA A;  3IDD A;  4LR2 A; 
#chains in the Genus database with same CATH homology
 1ED8 A;  4KJG A;  2W5Q A;  3LXQ A;  3T02 A;  4LRC A;  1EQJ A;  2RH6 A;  4LR8 A;  1ED9 A;  1ALI A;  4UPI A;  3UN3 A;  3BDH A;  1E33 P;  4GTW A;  4N7T A;  3WBH A;  2W5W A;  2W5X A;  1Y7A A;  4LRD A;  2W5S A;  4UPH A;  5L0K A;  3TX0 A;  3M7V A;  4LR9 A;  3KD8 A;  4ZG9 A;  5AJ9 A;  5LRN A;  3BDG B;  5EGH A;  3E2D A;  2XR9 A;  4KAY A;  4LRE A;  5K4P A;  1SHN A;  4ZG6 A;  4UOO A;  5KXA A;  5L0B A;  3MK1 A;  3NKN A;  1FSU A;  3IGY B;  4CXK A;  5IJS A;  3M8Z A;  4ZG7 A;  2IUC B;  4CXS A;  1E3C P;  1EW2 A;  5INH A;  1KH4 A;  4YR1 A;  4KAV A;  4CYR A;  1HJK A;  1ALH A;  1ALJ A;  4UPL A;  1O99 A;  2ANH A;  5TJ3 A;  4UPK A;  3A52 A;  3T00 A;  1KHJ A;  2W8D A;  3NKO A;  5GOV A;  5HRT A;  4UOR A;  4GTX A;  2W5T A;  3M8W A;  4MY4 A;  2GSU A;  1KHK A;  3DYC A;  3NKP A;  1URB A;  2D1G A;  1ELX A;  2W8S A;  1EJJ A;  3ED4 A;  3M8Y A;  1E2S P;  1ANI A;  1KH9 A;  2XRG A;  3B5Q A;  1EW8 A;  4KJD A;  4MHX A;  1Y6V A;  1SHQ A;  1N2L A;  4QAX A;  3UN5 A;  4LQY A;  1HDH A;  5DLW A;  1KH5 A;  3UO0 A;  2GA3 A;  4LRF A;  1KH7 A;  3MK0 A;  1KHN A;  2W5V A;  4LRB A;  3UNY A;  3MK2 A;  5LIA A;  2GLQ A;  3WAX A;  3UN2 A;  1ALK A;  1B8J A;  4GTY A;  5IJQ A;  3IGZ B;  3T01 A;  5EGE A;  3OT9 A;  1HQA A;  5LRM A;  1AJA A;  1AJD A;  1K7H A;  2ZKT A;  1EW9 A;  4TN0 A;  1AJC A;  3DPC A;  3NVL A;  1P49 A;  4CYS A;  4FDI A;  1ZED A;  3NKM A;  3Q3Q A;  4LR7 A;  3WAV A;  1N2K A;  4GTZ A;  4LRA A;  1ELY A;  4MIV A;  3SZY A;  4B56 A;  1E1Z P;  3BDG A;  1KHL A;  3CMR A;  2GSN A;  1URA A;  2VQR A;  3BDF A;  4NWX A;  5LQQ A;  2W5R A;  3NKQ A;  1ZEB A;  3WAY A;  2GSO A;  5DLT A;  2IUC A;  1AUK A;  5C66 A;  4CXU A;  2X98 A;  2G9Y A;  5L0E A;  4NWJ A;  3SZZ A;  3TWZ A;  2IFY A;  4KM4 A;  2QZU A;  3NKR A;  5DLV A;  1ANJ A;  4UOP A;  3TG0 A;  3WAW A;  1ELZ A;  1EI6 A;  1AJB A;  1O98 A;  1ZEF A;  4FDJ A;  5GRR A;  4ZGA A;  3IDD A;  4LR2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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