1ELYA

E. coli alkaline phosphatase mutant (s102c)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDCAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elyA00
3LXQA 2W5TA 1ANJA 3E2DA 1ALJA 2GSUA 4LR9A 3MK0A 4LR7A 2W5QA 3NKQA 4CXUA 4CXKA 1EQJA 5LQQA 4UPIA 2W5VA 2GA3A 4QAXA 3UO0A 5IJSA 1KH4A 3B5QA 4ZG9A 2RH6A 3MK2A 5AJ9A 1FSUA 3CMRA 5LRNA 1E33P 5LIAA 3A52A 4CYRA 1O99A 1AJBA 4UOPA 4TN0A 4LRFA 4YR1A 4ZG7A 1E1ZP 1AJAA 5INHA 3TX0A 4GTZA 4KAVA 5C66A 3NKPA 4LR2A 3BDGA 3T00A 3UN2A 4N7TA 3DPCA 4CXSA 1E2SP 2VQRA 1ELZA 3KD8A 5L0BA 1ELXA 3TG0A 4UOOA 1HDHA 3DYCA 3WAYA 3BDFA 5DLWA 1ED9A 4UORA 3NVLA 3UN5A 5KXAA 1P49A 2QZUA 3SZZA 1KH5A 1ALKA 2IFYA 3T02A 5LRMA 2W5WA 2W5SA 3TWZA 5L0KA 2GSNA 1EJJA 3BDGB 3UNYA 2X98A 2W8SA 1SHNA 4KAYA 1AJCA 3T01A 4GTYA 1KH7A 4KJGA 3ED4A 2D1GA 3M8WA 5EGEA 5EGHA 1ZEFA 4B56A 4GTXA 3NKMA 3IGYB 5DLTA 3OT9A 3M7VA 1AJDA 1KHLA 2XRGA 1N2LA 1AUKA 1URBA 3BDHA 2GSOA 4KJDA 4LRDA 4MY4A 5IJQA 2ZKTA 1KHNA 2IUCA 1URAA 2ANHA 1ED8A 4KM4A 1ELYA 1B8JA 2XR9A 5TJ3A 1ANIA 1KH9A 1EI6A 1E3CP 4FDJA 2W5RA 3WAVA 4FDIA 3NKNA 1EW9A 3SZYA 1SHQA 4LR8A 4UPKA 4CYSA 3IGZB 1O98A 3UN3A 5K4PA 1ZEBA 2IUCB 1K7HA 1Y6VA 4UPHA 5HRTA 3Q3QA 2GLQA 2G9YA 1Y7AA 1ZEDA 4UPLA 3MK1A 4LRBA 3IDDA 1EW2A 4NWXA 3NKOA 4MIVA 3WAXA 3NKRA 3WBHA 4ZGAA 4MHXA 4ZG6A 3WAWA 1ALIA 1N2KA 5GRRA 1KHJA 4LREA 4LQYA 2W5XA 3M8ZA 5L0EA 4NWJA 1EW8A 4LRAA 4GTWA 2W8DA 3M8YA 5GOVA 1ALHA 1HJKA 5DLVA 4LRCA 1KHKA 1HQAA
chains in the Genus database with same CATH superfamily
3LXQA 2W5TA 1ANJA 3E2DA 1ALJA 2GSUA 4LR9A 3MK0A 4LR7A 2W5QA 3NKQA 4CXUA 4CXKA 1EQJA 5LQQA 4UPIA 2W5VA 2GA3A 4QAXA 3UO0A 5IJSA 1KH4A 3B5QA 4ZG9A 2RH6A 3MK2A 5AJ9A 1FSUA 3CMRA 5LRNA 1E33P 5LIAA 3A52A 4CYRA 1O99A 1AJBA 4UOPA 4TN0A 4LRFA 4YR1A 4ZG7A 1E1ZP 1AJAA 5INHA 3TX0A 4GTZA 4KAVA 5C66A 3NKPA 4LR2A 3BDGA 3T00A 3UN2A 4N7TA 3DPCA 4CXSA 1E2SP 2VQRA 1ELZA 3KD8A 5L0BA 1ELXA 3TG0A 4UOOA 1HDHA 3DYCA 3WAYA 3BDFA 5DLWA 1ED9A 4UORA 3NVLA 3UN5A 5KXAA 1P49A 2QZUA 3SZZA 1KH5A 1ALKA 2IFYA 3T02A 5LRMA 2W5WA 2W5SA 3TWZA 5L0KA 2GSNA 1EJJA 3BDGB 3UNYA 2X98A 2W8SA 1SHNA 4KAYA 1AJCA 3T01A 4GTYA 1KH7A 4KJGA 3ED4A 2D1GA 3M8WA 5EGEA 5EGHA 1ZEFA 4B56A 4GTXA 3NKMA 3IGYB 5DLTA 3OT9A 3M7VA 1AJDA 1KHLA 2XRGA 1N2LA 1AUKA 1URBA 3BDHA 2GSOA 4KJDA 4LRDA 4MY4A 5IJQA 2ZKTA 1KHNA 2IUCA 1URAA 2ANHA 1ED8A 4KM4A 1ELYA 1B8JA 2XR9A 5TJ3A 1ANIA 1KH9A 1EI6A 1E3CP 4FDJA 2W5RA 3WAVA 4FDIA 3NKNA 1EW9A 3SZYA 1SHQA 4LR8A 4UPKA 4CYSA 3IGZB 1O98A 3UN3A 5K4PA 1ZEBA 2IUCB 1K7HA 1Y6VA 4UPHA 5HRTA 3Q3QA 2GLQA 2G9YA 1Y7AA 1ZEDA 4UPLA 3MK1A 4LRBA 3IDDA 1EW2A 4NWXA 3NKOA 4MIVA 3WAXA 3NKRA 3WBHA 4ZGAA 4MHXA 4ZG6A 3WAWA 1ALIA 1N2KA 5GRRA 1KHJA 4LREA 4LQYA 2W5XA 3M8ZA 5L0EA 4NWJA 1EW8A 4LRAA 4GTWA 2W8DA 3M8YA 5GOVA 1ALHA 1HJKA 5DLVA 4LRCA 1KHKA 1HQAA
chains in the Genus database with same CATH topology
3LXQA 2W5TA 1ANJA 3E2DA 1ALJA 2GSUA 4LR9A 3MK0A 4LR7A 2W5QA 3NKQA 4CXUA 4CXKA 1EQJA 5LQQA 4UPIA 2W5VA 2GA3A 4QAXA 3UO0A 5IJSA 1KH4A 3B5QA 4ZG9A 2RH6A 3MK2A 5AJ9A 1FSUA 3CMRA 5LRNA 1E33P 5LIAA 3A52A 4CYRA 1O99A 1AJBA 4UOPA 4TN0A 4LRFA 4YR1A 4ZG7A 1E1ZP 1AJAA 5INHA 3TX0A 4GTZA 4KAVA 5C66A 3NKPA 4LR2A 3BDGA 3T00A 3UN2A 4N7TA 3DPCA 4CXSA 1E2SP 2VQRA 1ELZA 3KD8A 5L0BA 1ELXA 3TG0A 4UOOA 1HDHA 3DYCA 3WAYA 3BDFA 5DLWA 1ED9A 4UORA 3NVLA 3UN5A 5KXAA 1P49A 2QZUA 3SZZA 1KH5A 1ALKA 2IFYA 3T02A 5LRMA 2W5WA 2W5SA 3TWZA 5L0KA 2GSNA 1EJJA 3BDGB 3UNYA 2X98A 2W8SA 1SHNA 4KAYA 1AJCA 3T01A 4GTYA 1KH7A 4KJGA 3ED4A 2D1GA 3M8WA 5EGEA 5EGHA 1ZEFA 4B56A 4GTXA 3NKMA 3IGYB 5DLTA 3OT9A 3M7VA 1AJDA 1KHLA 2XRGA 1N2LA 1AUKA 1URBA 3BDHA 2GSOA 4KJDA 4LRDA 4MY4A 5IJQA 2ZKTA 1KHNA 2IUCA 1URAA 2ANHA 1ED8A 4KM4A 1ELYA 1B8JA 2XR9A 5TJ3A 1ANIA 1KH9A 1EI6A 1E3CP 4FDJA 2W5RA 3WAVA 4FDIA 3NKNA 1EW9A 3SZYA 1SHQA 4LR8A 4UPKA 4CYSA 3IGZB 1O98A 3UN3A 5K4PA 1ZEBA 2IUCB 1K7HA 1Y6VA 4UPHA 5HRTA 3Q3QA 2GLQA 2G9YA 1Y7AA 1ZEDA 4UPLA 3MK1A 4LRBA 3IDDA 1EW2A 4NWXA 3NKOA 4MIVA 3WAXA 3NKRA 3WBHA 4ZGAA 4MHXA 4ZG6A 3WAWA 1ALIA 1N2KA 5GRRA 1KHJA 4LREA 4LQYA 2W5XA 3M8ZA 5L0EA 4NWJA 1EW8A 4LRAA 4GTWA 2W8DA 3M8YA 5GOVA 1ALHA 1HJKA 5DLVA 4LRCA 1KHKA 1HQAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LXQ A;  2W5T A;  1ANJ A;  3E2D A;  1ALJ A;  2GSU A;  4LR9 A;  3MK0 A;  4LR7 A;  2W5Q A;  3NKQ A;  4CXU A;  4CXK A;  1EQJ A;  5LQQ A;  4UPI A;  2W5V A;  2GA3 A;  4QAX A;  3UO0 A;  5IJS A;  1KH4 A;  3B5Q A;  4ZG9 A;  2RH6 A;  3MK2 A;  5AJ9 A;  1FSU A;  3CMR A;  5LRN A;  1E33 P;  5LIA A;  3A52 A;  4CYR A;  1O99 A;  1AJB A;  4UOP A;  4TN0 A;  4LRF A;  4YR1 A;  4ZG7 A;  1E1Z P;  1AJA A;  5INH A;  3TX0 A;  4GTZ A;  4KAV A;  5C66 A;  3NKP A;  4LR2 A;  3BDG A;  3T00 A;  3UN2 A;  4N7T A;  3DPC A;  4CXS A;  1E2S P;  2VQR A;  1ELZ A;  3KD8 A;  5L0B A;  1ELX A;  3TG0 A;  4UOO A;  1HDH A;  3DYC A;  3WAY A;  3BDF A;  5DLW A;  1ED9 A;  4UOR A;  3NVL A;  3UN5 A;  5KXA A;  1P49 A;  2QZU A;  3SZZ A;  1KH5 A;  1ALK A;  2IFY A;  3T02 A;  5LRM A;  2W5W A;  2W5S A;  3TWZ A;  5L0K A;  2GSN A;  1EJJ A;  3BDG B;  3UNY A;  2X98 A;  2W8S A;  1SHN A;  4KAY A;  1AJC A;  3T01 A;  4GTY A;  1KH7 A;  4KJG A;  3ED4 A;  2D1G A;  3M8W A;  5EGE A;  5EGH A;  1ZEF A;  4B56 A;  4GTX A;  3NKM A;  3IGY B;  5DLT A;  3OT9 A;  3M7V A;  1AJD A;  1KHL A;  2XRG A;  1N2L A;  1AUK A;  1URB A;  3BDH A;  2GSO A;  4KJD A;  4LRD A;  4MY4 A;  5IJQ A;  2ZKT A;  1KHN A;  2IUC A;  1URA A;  2ANH A;  1ED8 A;  4KM4 A;  1ELY A;  1B8J A;  2XR9 A;  5TJ3 A;  1ANI A;  1KH9 A;  1EI6 A;  1E3C P;  4FDJ A;  2W5R A;  3WAV A;  4FDI A;  3NKN A;  1EW9 A;  3SZY A;  1SHQ A;  4LR8 A;  4UPK A;  4CYS A;  3IGZ B;  1O98 A;  3UN3 A;  5K4P A;  1ZEB A;  2IUC B;  1K7H A;  1Y6V A;  4UPH A;  5HRT A;  3Q3Q A;  2GLQ A;  2G9Y A;  1Y7A A;  1ZED A;  4UPL A;  3MK1 A;  4LRB A;  3IDD A;  1EW2 A;  4NWX A;  3NKO A;  4MIV A;  3WAX A;  3NKR A;  3WBH A;  4ZGA A;  4MHX A;  4ZG6 A;  3WAW A;  1ALI A;  1N2K A;  5GRR A;  1KHJ A;  4LRE A;  4LQY A;  2W5X A;  3M8Z A;  5L0E A;  4NWJ A;  1EW8 A;  4LRA A;  4GTW A;  2W8D A;  3M8Y A;  5GOV A;  1ALH A;  1HJK A;  5DLV A;  4LRC A;  1KHK A;  1HQA A; 
#chains in the Genus database with same CATH topology
 3LXQ A;  2W5T A;  1ANJ A;  3E2D A;  1ALJ A;  2GSU A;  4LR9 A;  3MK0 A;  4LR7 A;  2W5Q A;  3NKQ A;  4CXU A;  4CXK A;  1EQJ A;  5LQQ A;  4UPI A;  2W5V A;  2GA3 A;  4QAX A;  3UO0 A;  5IJS A;  1KH4 A;  3B5Q A;  4ZG9 A;  2RH6 A;  3MK2 A;  5AJ9 A;  1FSU A;  3CMR A;  5LRN A;  1E33 P;  5LIA A;  3A52 A;  4CYR A;  1O99 A;  1AJB A;  4UOP A;  4TN0 A;  4LRF A;  4YR1 A;  4ZG7 A;  1E1Z P;  1AJA A;  5INH A;  3TX0 A;  4GTZ A;  4KAV A;  5C66 A;  3NKP A;  4LR2 A;  3BDG A;  3T00 A;  3UN2 A;  4N7T A;  3DPC A;  4CXS A;  1E2S P;  2VQR A;  1ELZ A;  3KD8 A;  5L0B A;  1ELX A;  3TG0 A;  4UOO A;  1HDH A;  3DYC A;  3WAY A;  3BDF A;  5DLW A;  1ED9 A;  4UOR A;  3NVL A;  3UN5 A;  5KXA A;  1P49 A;  2QZU A;  3SZZ A;  1KH5 A;  1ALK A;  2IFY A;  3T02 A;  5LRM A;  2W5W A;  2W5S A;  3TWZ A;  5L0K A;  2GSN A;  1EJJ A;  3BDG B;  3UNY A;  2X98 A;  2W8S A;  1SHN A;  4KAY A;  1AJC A;  3T01 A;  4GTY A;  1KH7 A;  4KJG A;  3ED4 A;  2D1G A;  3M8W A;  5EGE A;  5EGH A;  1ZEF A;  4B56 A;  4GTX A;  3NKM A;  3IGY B;  5DLT A;  3OT9 A;  3M7V A;  1AJD A;  1KHL A;  2XRG A;  1N2L A;  1AUK A;  1URB A;  3BDH A;  2GSO A;  4KJD A;  4LRD A;  4MY4 A;  5IJQ A;  2ZKT A;  1KHN A;  2IUC A;  1URA A;  2ANH A;  1ED8 A;  4KM4 A;  1ELY A;  1B8J A;  2XR9 A;  5TJ3 A;  1ANI A;  1KH9 A;  1EI6 A;  1E3C P;  4FDJ A;  2W5R A;  3WAV A;  4FDI A;  3NKN A;  1EW9 A;  3SZY A;  1SHQ A;  4LR8 A;  4UPK A;  4CYS A;  3IGZ B;  1O98 A;  3UN3 A;  5K4P A;  1ZEB A;  2IUC B;  1K7H A;  1Y6V A;  4UPH A;  5HRT A;  3Q3Q A;  2GLQ A;  2G9Y A;  1Y7A A;  1ZED A;  4UPL A;  3MK1 A;  4LRB A;  3IDD A;  1EW2 A;  4NWX A;  3NKO A;  4MIV A;  3WAX A;  3NKR A;  3WBH A;  4ZGA A;  4MHX A;  4ZG6 A;  3WAW A;  1ALI A;  1N2K A;  5GRR A;  1KHJ A;  4LRE A;  4LQY A;  2W5X A;  3M8Z A;  5L0E A;  4NWJ A;  1EW8 A;  4LRA A;  4GTW A;  2W8D A;  3M8Y A;  5GOV A;  1ALH A;  1HJK A;  5DLV A;  4LRC A;  1KHK A;  1HQA A; 
#chains in the Genus database with same CATH homology
 3LXQ A;  2W5T A;  1ANJ A;  3E2D A;  1ALJ A;  2GSU A;  4LR9 A;  3MK0 A;  4LR7 A;  2W5Q A;  3NKQ A;  4CXU A;  4CXK A;  1EQJ A;  5LQQ A;  4UPI A;  2W5V A;  2GA3 A;  4QAX A;  3UO0 A;  5IJS A;  1KH4 A;  3B5Q A;  4ZG9 A;  2RH6 A;  3MK2 A;  5AJ9 A;  1FSU A;  3CMR A;  5LRN A;  1E33 P;  5LIA A;  3A52 A;  4CYR A;  1O99 A;  1AJB A;  4UOP A;  4TN0 A;  4LRF A;  4YR1 A;  4ZG7 A;  1E1Z P;  1AJA A;  5INH A;  3TX0 A;  4GTZ A;  4KAV A;  5C66 A;  3NKP A;  4LR2 A;  3BDG A;  3T00 A;  3UN2 A;  4N7T A;  3DPC A;  4CXS A;  1E2S P;  2VQR A;  1ELZ A;  3KD8 A;  5L0B A;  1ELX A;  3TG0 A;  4UOO A;  1HDH A;  3DYC A;  3WAY A;  3BDF A;  5DLW A;  1ED9 A;  4UOR A;  3NVL A;  3UN5 A;  5KXA A;  1P49 A;  2QZU A;  3SZZ A;  1KH5 A;  1ALK A;  2IFY A;  3T02 A;  5LRM A;  2W5W A;  2W5S A;  3TWZ A;  5L0K A;  2GSN A;  1EJJ A;  3BDG B;  3UNY A;  2X98 A;  2W8S A;  1SHN A;  4KAY A;  1AJC A;  3T01 A;  4GTY A;  1KH7 A;  4KJG A;  3ED4 A;  2D1G A;  3M8W A;  5EGE A;  5EGH A;  1ZEF A;  4B56 A;  4GTX A;  3NKM A;  3IGY B;  5DLT A;  3OT9 A;  3M7V A;  1AJD A;  1KHL A;  2XRG A;  1N2L A;  1AUK A;  1URB A;  3BDH A;  2GSO A;  4KJD A;  4LRD A;  4MY4 A;  5IJQ A;  2ZKT A;  1KHN A;  2IUC A;  1URA A;  2ANH A;  1ED8 A;  4KM4 A;  1ELY A;  1B8J A;  2XR9 A;  5TJ3 A;  1ANI A;  1KH9 A;  1EI6 A;  1E3C P;  4FDJ A;  2W5R A;  3WAV A;  4FDI A;  3NKN A;  1EW9 A;  3SZY A;  1SHQ A;  4LR8 A;  4UPK A;  4CYS A;  3IGZ B;  1O98 A;  3UN3 A;  5K4P A;  1ZEB A;  2IUC B;  1K7H A;  1Y6V A;  4UPH A;  5HRT A;  3Q3Q A;  2GLQ A;  2G9Y A;  1Y7A A;  1ZED A;  4UPL A;  3MK1 A;  4LRB A;  3IDD A;  1EW2 A;  4NWX A;  3NKO A;  4MIV A;  3WAX A;  3NKR A;  3WBH A;  4ZGA A;  4MHX A;  4ZG6 A;  3WAW A;  1ALI A;  1N2K A;  5GRR A;  1KHJ A;  4LRE A;  4LQY A;  2W5X A;  3M8Z A;  5L0E A;  4NWJ A;  1EW8 A;  4LRA A;  4GTW A;  2W8D A;  3M8Y A;  5GOV A;  1ALH A;  1HJK A;  5DLV A;  4LRC A;  1KHK A;  1HQA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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