1ELYA

E. coli alkaline phosphatase mutant (s102c)
Total Genus 157
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
157
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDCAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: insights into the catalytic mechanism without the nucleophile Ser102.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 157
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1998-02-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1elyA00
3Q3QA 1KH9A 2W5QA 4GTZA 1E3CP 2W5RA 3NKNA 2GSOA 3T02A 4MY4A 3NKMA 4LRAA 1HJKA 1AJAA 5LRMA 1ED9A 1FSUA 4TN0A 2IUCA 2X98A 1N2KA 1KHJA 2ZKTA 2QZUA 1KH7A 4KAYA 1ALIA 1ZEDA 2D1GA 5AJ9A 4CXSA 3NVLA 1Y7AA 2W5SA 4UOPA 4LRBA 1ELYA 3UN2A 1SHNA 3UN5A 5IJSA 1E2SP 1AJBA 1KHKA 4GTXA 3WAWA 4UPHA 4CYSA 2W5XA 3WAXA 1EW2A 5EGHA 3SZYA 5L0EA 1URBA 5HRTA 3TX0A 4ZG6A 5KXAA 1ALJA 1ELXA 3B5QA 1URAA 3BDGA 1O98A 1EQJA 4LR9A 4FDIA 1ANIA 4ZG7A 1ALHA 3DPCA 4GTWA 4UPLA 1AUKA 2W8SA 1KH4A 3NKQA 3E2DA 1KH5A 4LR7A 4KJGA 4MHXA 1HQAA 5IJQA 5DLWA 2RH6A 3M8YA 4QAXA 2IUCB 5C66A 3M8WA 1KHLA 4NWJA 3IGYB 3NKRA 3WBHA 5EGEA 4LRCA 1K7HA 2G9YA 3TWZA 3CMRA 3IGZB 1E1ZP 1KHNA 4KM4A 2W8DA 1P49A 4ZG9A 3TG0A 3MK0A 2XR9A 5GRRA 1ANJA 3M7VA 1HDHA 1AJCA 4LREA 1N2LA 2W5WA 4B56A 3DYCA 1EI6A 4FDJA 3SZZA 4YR1A 1EW9A 4LQYA 4UPIA 4CXKA 5L0BA 1E33P 4MIVA 5DLTA 3NKOA 5K4PA 3T01A 4ZGAA 5LQQA 3UO0A 2GLQA 2XRGA 2GSNA 5LIAA 1SHQA 3T00A 5LRNA 1ZEFA 4UOOA 3OT9A 1AJDA 2ANHA 2GA3A 5GOVA 5INHA 4NWXA 3ED4A 3LXQA 3KD8A 1Y6VA 1EJJA 2GSUA 2IFYA 4KJDA 3BDHA 1O99A 4CXUA 3MK1A 4UORA 3UN3A 3UNYA 4LRFA 4N7TA 5TJ3A 3NKPA 4GTYA 1ELZA 1ED8A 4CYRA 3A52A 3WAVA 2W5VA 5DLVA 3M8ZA 1B8JA 3BDFA 4LR8A 1EW8A 4LR2A 3WAYA 3BDGB 5L0KA 3MK2A 1ALKA 3IDDA 1ZEBA 2VQRA 2W5TA 4LRDA 4KAVA 4UPKA
chains in the Genus database with same CATH superfamily
3Q3QA 1KH9A 2W5QA 4GTZA 1E3CP 2W5RA 3NKNA 2GSOA 3T02A 4MY4A 3NKMA 4LRAA 1HJKA 1AJAA 5LRMA 1ED9A 1FSUA 4TN0A 2IUCA 2X98A 1N2KA 1KHJA 2ZKTA 2QZUA 1KH7A 4KAYA 1ALIA 1ZEDA 2D1GA 5AJ9A 4CXSA 3NVLA 1Y7AA 2W5SA 4UOPA 4LRBA 1ELYA 3UN2A 1SHNA 3UN5A 5IJSA 1E2SP 1AJBA 1KHKA 4GTXA 3WAWA 4UPHA 4CYSA 2W5XA 3WAXA 1EW2A 5EGHA 3SZYA 5L0EA 1URBA 5HRTA 3TX0A 4ZG6A 5KXAA 1ALJA 1ELXA 3B5QA 1URAA 3BDGA 1O98A 1EQJA 4LR9A 4FDIA 1ANIA 4ZG7A 1ALHA 3DPCA 4GTWA 4UPLA 1AUKA 2W8SA 1KH4A 3NKQA 3E2DA 1KH5A 4LR7A 4KJGA 4MHXA 1HQAA 5IJQA 5DLWA 2RH6A 3M8YA 4QAXA 2IUCB 5C66A 3M8WA 1KHLA 4NWJA 3IGYB 3NKRA 3WBHA 5EGEA 4LRCA 1K7HA 2G9YA 3TWZA 3CMRA 3IGZB 1E1ZP 1KHNA 4KM4A 2W8DA 1P49A 4ZG9A 3TG0A 3MK0A 2XR9A 5GRRA 1ANJA 3M7VA 1HDHA 1AJCA 4LREA 1N2LA 2W5WA 4B56A 3DYCA 1EI6A 4FDJA 3SZZA 4YR1A 1EW9A 4LQYA 4UPIA 4CXKA 5L0BA 1E33P 4MIVA 5DLTA 3NKOA 5K4PA 3T01A 4ZGAA 5LQQA 3UO0A 2GLQA 2XRGA 2GSNA 5LIAA 1SHQA 3T00A 5LRNA 1ZEFA 4UOOA 3OT9A 1AJDA 2ANHA 2GA3A 5GOVA 5INHA 4NWXA 3ED4A 3LXQA 3KD8A 1Y6VA 1EJJA 2GSUA 2IFYA 4KJDA 3BDHA 1O99A 4CXUA 3MK1A 4UORA 3UN3A 3UNYA 4LRFA 4N7TA 5TJ3A 3NKPA 4GTYA 1ELZA 1ED8A 4CYRA 3A52A 3WAVA 2W5VA 5DLVA 3M8ZA 1B8JA 3BDFA 4LR8A 1EW8A 4LR2A 3WAYA 3BDGB 5L0KA 3MK2A 1ALKA 3IDDA 1ZEBA 2VQRA 2W5TA 4LRDA 4KAVA 4UPKA
chains in the Genus database with same CATH topology
3Q3QA 1KH9A 2W5QA 4GTZA 1E3CP 2W5RA 3NKNA 2GSOA 3T02A 4MY4A 3NKMA 4LRAA 1HJKA 1AJAA 5LRMA 1ED9A 1FSUA 4TN0A 2IUCA 2X98A 1N2KA 1KHJA 2ZKTA 2QZUA 1KH7A 4KAYA 1ALIA 1ZEDA 2D1GA 5AJ9A 4CXSA 3NVLA 1Y7AA 2W5SA 4UOPA 4LRBA 1ELYA 3UN2A 1SHNA 3UN5A 5IJSA 1E2SP 1AJBA 1KHKA 4GTXA 3WAWA 4UPHA 4CYSA 2W5XA 3WAXA 1EW2A 5EGHA 3SZYA 5L0EA 1URBA 5HRTA 3TX0A 4ZG6A 5KXAA 1ALJA 1ELXA 3B5QA 1URAA 3BDGA 1O98A 1EQJA 4LR9A 4FDIA 1ANIA 4ZG7A 1ALHA 3DPCA 4GTWA 4UPLA 1AUKA 2W8SA 1KH4A 3NKQA 3E2DA 1KH5A 4LR7A 4KJGA 4MHXA 1HQAA 5IJQA 5DLWA 2RH6A 3M8YA 4QAXA 2IUCB 5C66A 3M8WA 1KHLA 4NWJA 3IGYB 3NKRA 3WBHA 5EGEA 4LRCA 1K7HA 2G9YA 3TWZA 3CMRA 3IGZB 1E1ZP 1KHNA 4KM4A 2W8DA 1P49A 4ZG9A 3TG0A 3MK0A 2XR9A 5GRRA 1ANJA 3M7VA 1HDHA 1AJCA 4LREA 1N2LA 2W5WA 4B56A 3DYCA 1EI6A 4FDJA 3SZZA 4YR1A 1EW9A 4LQYA 4UPIA 4CXKA 5L0BA 1E33P 4MIVA 5DLTA 3NKOA 5K4PA 3T01A 4ZGAA 5LQQA 3UO0A 2GLQA 2XRGA 2GSNA 5LIAA 1SHQA 3T00A 5LRNA 1ZEFA 4UOOA 3OT9A 1AJDA 2ANHA 2GA3A 5GOVA 5INHA 4NWXA 3ED4A 3LXQA 3KD8A 1Y6VA 1EJJA 2GSUA 2IFYA 4KJDA 3BDHA 1O99A 4CXUA 3MK1A 4UORA 3UN3A 3UNYA 4LRFA 4N7TA 5TJ3A 3NKPA 4GTYA 1ELZA 1ED8A 4CYRA 3A52A 3WAVA 2W5VA 5DLVA 3M8ZA 1B8JA 3BDFA 4LR8A 1EW8A 4LR2A 3WAYA 3BDGB 5L0KA 3MK2A 1ALKA 3IDDA 1ZEBA 2VQRA 2W5TA 4LRDA 4KAVA 4UPKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3Q3Q A;  1KH9 A;  2W5Q A;  4GTZ A;  1E3C P;  2W5R A;  3NKN A;  2GSO A;  3T02 A;  4MY4 A;  3NKM A;  4LRA A;  1HJK A;  1AJA A;  5LRM A;  1ED9 A;  1FSU A;  4TN0 A;  2IUC A;  2X98 A;  1N2K A;  1KHJ A;  2ZKT A;  2QZU A;  1KH7 A;  4KAY A;  1ALI A;  1ZED A;  2D1G A;  5AJ9 A;  4CXS A;  3NVL A;  1Y7A A;  2W5S A;  4UOP A;  4LRB A;  1ELY A;  3UN2 A;  1SHN A;  3UN5 A;  5IJS A;  1E2S P;  1AJB A;  1KHK A;  4GTX A;  3WAW A;  4UPH A;  4CYS A;  2W5X A;  3WAX A;  1EW2 A;  5EGH A;  3SZY A;  5L0E A;  1URB A;  5HRT A;  3TX0 A;  4ZG6 A;  5KXA A;  1ALJ A;  1ELX A;  3B5Q A;  1URA A;  3BDG A;  1O98 A;  1EQJ A;  4LR9 A;  4FDI A;  1ANI A;  4ZG7 A;  1ALH A;  3DPC A;  4GTW A;  4UPL A;  1AUK A;  2W8S A;  1KH4 A;  3NKQ A;  3E2D A;  1KH5 A;  4LR7 A;  4KJG A;  4MHX A;  1HQA A;  5IJQ A;  5DLW A;  2RH6 A;  3M8Y A;  4QAX A;  2IUC B;  5C66 A;  3M8W A;  1KHL A;  4NWJ A;  3IGY B;  3NKR A;  3WBH A;  5EGE A;  4LRC A;  1K7H A;  2G9Y A;  3TWZ A;  3CMR A;  3IGZ B;  1E1Z P;  1KHN A;  4KM4 A;  2W8D A;  1P49 A;  4ZG9 A;  3TG0 A;  3MK0 A;  2XR9 A;  5GRR A;  1ANJ A;  3M7V A;  1HDH A;  1AJC A;  4LRE A;  1N2L A;  2W5W A;  4B56 A;  3DYC A;  1EI6 A;  4FDJ A;  3SZZ A;  4YR1 A;  1EW9 A;  4LQY A;  4UPI A;  4CXK A;  5L0B A;  1E33 P;  4MIV A;  5DLT A;  3NKO A;  5K4P A;  3T01 A;  4ZGA A;  5LQQ A;  3UO0 A;  2GLQ A;  2XRG A;  2GSN A;  5LIA A;  1SHQ A;  3T00 A;  5LRN A;  1ZEF A;  4UOO A;  3OT9 A;  1AJD A;  2ANH A;  2GA3 A;  5GOV A;  5INH A;  4NWX A;  3ED4 A;  3LXQ A;  3KD8 A;  1Y6V A;  1EJJ A;  2GSU A;  2IFY A;  4KJD A;  3BDH A;  1O99 A;  4CXU A;  3MK1 A;  4UOR A;  3UN3 A;  3UNY A;  4LRF A;  4N7T A;  5TJ3 A;  3NKP A;  4GTY A;  1ELZ A;  1ED8 A;  4CYR A;  3A52 A;  3WAV A;  2W5V A;  5DLV A;  3M8Z A;  1B8J A;  3BDF A;  4LR8 A;  1EW8 A;  4LR2 A;  3WAY A;  3BDG B;  5L0K A;  3MK2 A;  1ALK A;  3IDD A;  1ZEB A;  2VQR A;  2W5T A;  4LRD A;  4KAV A;  4UPK A; 
#chains in the Genus database with same CATH topology
 3Q3Q A;  1KH9 A;  2W5Q A;  4GTZ A;  1E3C P;  2W5R A;  3NKN A;  2GSO A;  3T02 A;  4MY4 A;  3NKM A;  4LRA A;  1HJK A;  1AJA A;  5LRM A;  1ED9 A;  1FSU A;  4TN0 A;  2IUC A;  2X98 A;  1N2K A;  1KHJ A;  2ZKT A;  2QZU A;  1KH7 A;  4KAY A;  1ALI A;  1ZED A;  2D1G A;  5AJ9 A;  4CXS A;  3NVL A;  1Y7A A;  2W5S A;  4UOP A;  4LRB A;  1ELY A;  3UN2 A;  1SHN A;  3UN5 A;  5IJS A;  1E2S P;  1AJB A;  1KHK A;  4GTX A;  3WAW A;  4UPH A;  4CYS A;  2W5X A;  3WAX A;  1EW2 A;  5EGH A;  3SZY A;  5L0E A;  1URB A;  5HRT A;  3TX0 A;  4ZG6 A;  5KXA A;  1ALJ A;  1ELX A;  3B5Q A;  1URA A;  3BDG A;  1O98 A;  1EQJ A;  4LR9 A;  4FDI A;  1ANI A;  4ZG7 A;  1ALH A;  3DPC A;  4GTW A;  4UPL A;  1AUK A;  2W8S A;  1KH4 A;  3NKQ A;  3E2D A;  1KH5 A;  4LR7 A;  4KJG A;  4MHX A;  1HQA A;  5IJQ A;  5DLW A;  2RH6 A;  3M8Y A;  4QAX A;  2IUC B;  5C66 A;  3M8W A;  1KHL A;  4NWJ A;  3IGY B;  3NKR A;  3WBH A;  5EGE A;  4LRC A;  1K7H A;  2G9Y A;  3TWZ A;  3CMR A;  3IGZ B;  1E1Z P;  1KHN A;  4KM4 A;  2W8D A;  1P49 A;  4ZG9 A;  3TG0 A;  3MK0 A;  2XR9 A;  5GRR A;  1ANJ A;  3M7V A;  1HDH A;  1AJC A;  4LRE A;  1N2L A;  2W5W A;  4B56 A;  3DYC A;  1EI6 A;  4FDJ A;  3SZZ A;  4YR1 A;  1EW9 A;  4LQY A;  4UPI A;  4CXK A;  5L0B A;  1E33 P;  4MIV A;  5DLT A;  3NKO A;  5K4P A;  3T01 A;  4ZGA A;  5LQQ A;  3UO0 A;  2GLQ A;  2XRG A;  2GSN A;  5LIA A;  1SHQ A;  3T00 A;  5LRN A;  1ZEF A;  4UOO A;  3OT9 A;  1AJD A;  2ANH A;  2GA3 A;  5GOV A;  5INH A;  4NWX A;  3ED4 A;  3LXQ A;  3KD8 A;  1Y6V A;  1EJJ A;  2GSU A;  2IFY A;  4KJD A;  3BDH A;  1O99 A;  4CXU A;  3MK1 A;  4UOR A;  3UN3 A;  3UNY A;  4LRF A;  4N7T A;  5TJ3 A;  3NKP A;  4GTY A;  1ELZ A;  1ED8 A;  4CYR A;  3A52 A;  3WAV A;  2W5V A;  5DLV A;  3M8Z A;  1B8J A;  3BDF A;  4LR8 A;  1EW8 A;  4LR2 A;  3WAY A;  3BDG B;  5L0K A;  3MK2 A;  1ALK A;  3IDD A;  1ZEB A;  2VQR A;  2W5T A;  4LRD A;  4KAV A;  4UPK A; 
#chains in the Genus database with same CATH homology
 3Q3Q A;  1KH9 A;  2W5Q A;  4GTZ A;  1E3C P;  2W5R A;  3NKN A;  2GSO A;  3T02 A;  4MY4 A;  3NKM A;  4LRA A;  1HJK A;  1AJA A;  5LRM A;  1ED9 A;  1FSU A;  4TN0 A;  2IUC A;  2X98 A;  1N2K A;  1KHJ A;  2ZKT A;  2QZU A;  1KH7 A;  4KAY A;  1ALI A;  1ZED A;  2D1G A;  5AJ9 A;  4CXS A;  3NVL A;  1Y7A A;  2W5S A;  4UOP A;  4LRB A;  1ELY A;  3UN2 A;  1SHN A;  3UN5 A;  5IJS A;  1E2S P;  1AJB A;  1KHK A;  4GTX A;  3WAW A;  4UPH A;  4CYS A;  2W5X A;  3WAX A;  1EW2 A;  5EGH A;  3SZY A;  5L0E A;  1URB A;  5HRT A;  3TX0 A;  4ZG6 A;  5KXA A;  1ALJ A;  1ELX A;  3B5Q A;  1URA A;  3BDG A;  1O98 A;  1EQJ A;  4LR9 A;  4FDI A;  1ANI A;  4ZG7 A;  1ALH A;  3DPC A;  4GTW A;  4UPL A;  1AUK A;  2W8S A;  1KH4 A;  3NKQ A;  3E2D A;  1KH5 A;  4LR7 A;  4KJG A;  4MHX A;  1HQA A;  5IJQ A;  5DLW A;  2RH6 A;  3M8Y A;  4QAX A;  2IUC B;  5C66 A;  3M8W A;  1KHL A;  4NWJ A;  3IGY B;  3NKR A;  3WBH A;  5EGE A;  4LRC A;  1K7H A;  2G9Y A;  3TWZ A;  3CMR A;  3IGZ B;  1E1Z P;  1KHN A;  4KM4 A;  2W8D A;  1P49 A;  4ZG9 A;  3TG0 A;  3MK0 A;  2XR9 A;  5GRR A;  1ANJ A;  3M7V A;  1HDH A;  1AJC A;  4LRE A;  1N2L A;  2W5W A;  4B56 A;  3DYC A;  1EI6 A;  4FDJ A;  3SZZ A;  4YR1 A;  1EW9 A;  4LQY A;  4UPI A;  4CXK A;  5L0B A;  1E33 P;  4MIV A;  5DLT A;  3NKO A;  5K4P A;  3T01 A;  4ZGA A;  5LQQ A;  3UO0 A;  2GLQ A;  2XRG A;  2GSN A;  5LIA A;  1SHQ A;  3T00 A;  5LRN A;  1ZEF A;  4UOO A;  3OT9 A;  1AJD A;  2ANH A;  2GA3 A;  5GOV A;  5INH A;  4NWX A;  3ED4 A;  3LXQ A;  3KD8 A;  1Y6V A;  1EJJ A;  2GSU A;  2IFY A;  4KJD A;  3BDH A;  1O99 A;  4CXU A;  3MK1 A;  4UOR A;  3UN3 A;  3UNY A;  4LRF A;  4N7T A;  5TJ3 A;  3NKP A;  4GTY A;  1ELZ A;  1ED8 A;  4CYR A;  3A52 A;  3WAV A;  2W5V A;  5DLV A;  3M8Z A;  1B8J A;  3BDF A;  4LR8 A;  1EW8 A;  4LR2 A;  3WAY A;  3BDG B;  5L0K A;  3MK2 A;  1ALK A;  3IDD A;  1ZEB A;  2VQR A;  2W5T A;  4LRD A;  4KAV A;  4UPK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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