3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
2GSOA 4QAXA 4CYRA 1ALIA 2GA3A 2W5XA 4KM4A 3UN5A 4KJDA 1Y6VA 2W5SA 2W5QA 3WAVA 2IUCB 3IDDA 1ANJA 2ANHA 3BDFA 4LQYA 4ZGAA 5DLVA 3TG0A 4NWXA 1Y7AA 2IUCA 5TJ3A 2G9YA 1EI6A 1ELZA 2W5TA 1E3CP 4LRCA 3WAWA 3M7VA 4N7TA 1EQJA 4LRBA 3UN2A 3A52A 4FDJA 4TN0A 1ELYA 3BDGA 3BDHA 3OT9A 4LRAA 5K4PA 3TX0A 3SZYA 5HRTA 3MK2A 4LR8A 1KH9A 3T02A 3CMRA 1AJCA 1E33P 4B56A 1HJKA 3KD8A 4KAVA 4FDIA 5DLTA 3SZZA 3UNYA 4GTWA 3LXQA 2X98A 4UOOA 1SHNA 1ELXA 4LRDA 2W8SA 1E2SP 5L0KA 1P49A 1KHLA 2ZKTA 3NKQA 1O98A 2QZUA 5INHA 5EGEA 5L0EA 4LREA 5GOVA 1K7HA 3M8WA 3WAXA 2RH6A 3NVLA 1EW8A 1E1ZP 3IGZB 1ZEDA 3TWZA 3DPCA 4CXKA 1ZEBA 4NWJA 4UPLA 1ALJA 4LR7A 5EGHA 3NKOA 3NKRA 3NKNA 1AJDA 4ZG6A 1ALKA 1ALHA 5AJ9A 4GTXA 1FSUA 4YR1A 1N2KA 2IFYA 1KH4A 1KHJA 4LRFA 1HDHA 1EW2A 1URAA 1KH5A 1SHQA 3BDGB 4CYSA 5LIAA 5KXAA 2GLQA 5LQQA 4GTYA 1HQAA 4UORA 2GSUA 3T01A 3M8YA 1ED9A 4MIVA 4LR2A 5IJQA 5GRRA 2D1GA 1AUKA 3T00A 4UOPA 3DYCA 1O99A 2XR9A 5DLWA 2XRGA 4ZG7A 1URBA 3IGYB 3NKPA 4UPHA 2VQRA 3UN3A 5C66A 4ZG9A 4LR9A 4CXSA 3M8ZA 1ED8A 3B5QA 1AJAA 4KJGA 2W5VA 1ANIA 3NKMA 3E2DA 3WBHA 5IJSA 1N2LA 4UPIA 1AJBA 2W8DA 3MK0A 5L0BA 3UO0A 5LRMA 1EJJA 4CXUA 4MHXA 1EW9A 3ED4A 4KAYA 4GTZA 2GSNA 2W5WA 1ZEFA 5LRNA 3Q3QA 4MY4A 1B8JA 1KHKA 4UPKA 3WAYA 1KHNA 1KH7A 2W5RA 3MK1A
chains in the Genus database with same CATH superfamily
2GSOA 4QAXA 4CYRA 1ALIA 2GA3A 2W5XA 4KM4A 3UN5A 4KJDA 1Y6VA 2W5SA 2W5QA 3WAVA 2IUCB 3IDDA 1ANJA 2ANHA 3BDFA 4LQYA 4ZGAA 5DLVA 3TG0A 4NWXA 1Y7AA 2IUCA 5TJ3A 2G9YA 1EI6A 1ELZA 2W5TA 1E3CP 4LRCA 3WAWA 3M7VA 4N7TA 1EQJA 4LRBA 3UN2A 3A52A 4FDJA 4TN0A 1ELYA 3BDGA 3BDHA 3OT9A 4LRAA 5K4PA 3TX0A 3SZYA 5HRTA 3MK2A 4LR8A 1KH9A 3T02A 3CMRA 1AJCA 1E33P 4B56A 1HJKA 3KD8A 4KAVA 4FDIA 5DLTA 3SZZA 3UNYA 4GTWA 3LXQA 2X98A 4UOOA 1SHNA 1ELXA 4LRDA 2W8SA 1E2SP 5L0KA 1P49A 1KHLA 2ZKTA 3NKQA 1O98A 2QZUA 5INHA 5EGEA 5L0EA 4LREA 5GOVA 1K7HA 3M8WA 3WAXA 2RH6A 3NVLA 1EW8A 1E1ZP 3IGZB 1ZEDA 3TWZA 3DPCA 4CXKA 1ZEBA 4NWJA 4UPLA 1ALJA 4LR7A 5EGHA 3NKOA 3NKRA 3NKNA 1AJDA 4ZG6A 1ALKA 1ALHA 5AJ9A 4GTXA 1FSUA 4YR1A 1N2KA 2IFYA 1KH4A 1KHJA 4LRFA 1HDHA 1EW2A 1URAA 1KH5A 1SHQA 3BDGB 4CYSA 5LIAA 5KXAA 2GLQA 5LQQA 4GTYA 1HQAA 4UORA 2GSUA 3T01A 3M8YA 1ED9A 4MIVA 4LR2A 5IJQA 5GRRA 2D1GA 1AUKA 3T00A 4UOPA 3DYCA 1O99A 2XR9A 5DLWA 2XRGA 4ZG7A 1URBA 3IGYB 3NKPA 4UPHA 2VQRA 3UN3A 5C66A 4ZG9A 4LR9A 4CXSA 3M8ZA 1ED8A 3B5QA 1AJAA 4KJGA 2W5VA 1ANIA 3NKMA 3E2DA 3WBHA 5IJSA 1N2LA 4UPIA 1AJBA 2W8DA 3MK0A 5L0BA 3UO0A 5LRMA 1EJJA 4CXUA 4MHXA 1EW9A 3ED4A 4KAYA 4GTZA 2GSNA 2W5WA 1ZEFA 5LRNA 3Q3QA 4MY4A 1B8JA 1KHKA 4UPKA 3WAYA 1KHNA 1KH7A 2W5RA 3MK1A
chains in the Genus database with same CATH topology
2GSOA 4QAXA 4CYRA 1ALIA 2GA3A 2W5XA 4KM4A 3UN5A 4KJDA 1Y6VA 2W5SA 2W5QA 3WAVA 2IUCB 3IDDA 1ANJA 2ANHA 3BDFA 4LQYA 4ZGAA 5DLVA 3TG0A 4NWXA 1Y7AA 2IUCA 5TJ3A 2G9YA 1EI6A 1ELZA 2W5TA 1E3CP 4LRCA 3WAWA 3M7VA 4N7TA 1EQJA 4LRBA 3UN2A 3A52A 4FDJA 4TN0A 1ELYA 3BDGA 3BDHA 3OT9A 4LRAA 5K4PA 3TX0A 3SZYA 5HRTA 3MK2A 4LR8A 1KH9A 3T02A 3CMRA 1AJCA 1E33P 4B56A 1HJKA 3KD8A 4KAVA 4FDIA 5DLTA 3SZZA 3UNYA 4GTWA 3LXQA 2X98A 4UOOA 1SHNA 1ELXA 4LRDA 2W8SA 1E2SP 5L0KA 1P49A 1KHLA 2ZKTA 3NKQA 1O98A 2QZUA 5INHA 5EGEA 5L0EA 4LREA 5GOVA 1K7HA 3M8WA 3WAXA 2RH6A 3NVLA 1EW8A 1E1ZP 3IGZB 1ZEDA 3TWZA 3DPCA 4CXKA 1ZEBA 4NWJA 4UPLA 1ALJA 4LR7A 5EGHA 3NKOA 3NKRA 3NKNA 1AJDA 4ZG6A 1ALKA 1ALHA 5AJ9A 4GTXA 1FSUA 4YR1A 1N2KA 2IFYA 1KH4A 1KHJA 4LRFA 1HDHA 1EW2A 1URAA 1KH5A 1SHQA 3BDGB 4CYSA 5LIAA 5KXAA 2GLQA 5LQQA 4GTYA 1HQAA 4UORA 2GSUA 3T01A 3M8YA 1ED9A 4MIVA 4LR2A 5IJQA 5GRRA 2D1GA 1AUKA 3T00A 4UOPA 3DYCA 1O99A 2XR9A 5DLWA 2XRGA 4ZG7A 1URBA 3IGYB 3NKPA 4UPHA 2VQRA 3UN3A 5C66A 4ZG9A 4LR9A 4CXSA 3M8ZA 1ED8A 3B5QA 1AJAA 4KJGA 2W5VA 1ANIA 3NKMA 3E2DA 3WBHA 5IJSA 1N2LA 4UPIA 1AJBA 2W8DA 3MK0A 5L0BA 3UO0A 5LRMA 1EJJA 4CXUA 4MHXA 1EW9A 3ED4A 4KAYA 4GTZA 2GSNA 2W5WA 1ZEFA 5LRNA 3Q3QA 4MY4A 1B8JA 1KHKA 4UPKA 3WAYA 1KHNA 1KH7A 2W5RA 3MK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GSO A;  4QAX A;  4CYR A;  1ALI A;  2GA3 A;  2W5X A;  4KM4 A;  3UN5 A;  4KJD A;  1Y6V A;  2W5S A;  2W5Q A;  3WAV A;  2IUC B;  3IDD A;  1ANJ A;  2ANH A;  3BDF A;  4LQY A;  4ZGA A;  5DLV A;  3TG0 A;  4NWX A;  1Y7A A;  2IUC A;  5TJ3 A;  2G9Y A;  1EI6 A;  1ELZ A;  2W5T A;  1E3C P;  4LRC A;  3WAW A;  3M7V A;  4N7T A;  1EQJ A;  4LRB A;  3UN2 A;  3A52 A;  4FDJ A;  4TN0 A;  1ELY A;  3BDG A;  3BDH A;  3OT9 A;  4LRA A;  5K4P A;  3TX0 A;  3SZY A;  5HRT A;  3MK2 A;  4LR8 A;  1KH9 A;  3T02 A;  3CMR A;  1AJC A;  1E33 P;  4B56 A;  1HJK A;  3KD8 A;  4KAV A;  4FDI A;  5DLT A;  3SZZ A;  3UNY A;  4GTW A;  3LXQ A;  2X98 A;  4UOO A;  1SHN A;  1ELX A;  4LRD A;  2W8S A;  1E2S P;  5L0K A;  1P49 A;  1KHL A;  2ZKT A;  3NKQ A;  1O98 A;  2QZU A;  5INH A;  5EGE A;  5L0E A;  4LRE A;  5GOV A;  1K7H A;  3M8W A;  3WAX A;  2RH6 A;  3NVL A;  1EW8 A;  1E1Z P;  3IGZ B;  1ZED A;  3TWZ A;  3DPC A;  4CXK A;  1ZEB A;  4NWJ A;  4UPL A;  1ALJ A;  4LR7 A;  5EGH A;  3NKO A;  3NKR A;  3NKN A;  1AJD A;  4ZG6 A;  1ALK A;  1ALH A;  5AJ9 A;  4GTX A;  1FSU A;  4YR1 A;  1N2K A;  2IFY A;  1KH4 A;  1KHJ A;  4LRF A;  1HDH A;  1EW2 A;  1URA A;  1KH5 A;  1SHQ A;  3BDG B;  4CYS A;  5LIA A;  5KXA A;  2GLQ A;  5LQQ A;  4GTY A;  1HQA A;  4UOR A;  2GSU A;  3T01 A;  3M8Y A;  1ED9 A;  4MIV A;  4LR2 A;  5IJQ A;  5GRR A;  2D1G A;  1AUK A;  3T00 A;  4UOP A;  3DYC A;  1O99 A;  2XR9 A;  5DLW A;  2XRG A;  4ZG7 A;  1URB A;  3IGY B;  3NKP A;  4UPH A;  2VQR A;  3UN3 A;  5C66 A;  4ZG9 A;  4LR9 A;  4CXS A;  3M8Z A;  1ED8 A;  3B5Q A;  1AJA A;  4KJG A;  2W5V A;  1ANI A;  3NKM A;  3E2D A;  3WBH A;  5IJS A;  1N2L A;  4UPI A;  1AJB A;  2W8D A;  3MK0 A;  5L0B A;  3UO0 A;  5LRM A;  1EJJ A;  4CXU A;  4MHX A;  1EW9 A;  3ED4 A;  4KAY A;  4GTZ A;  2GSN A;  2W5W A;  1ZEF A;  5LRN A;  3Q3Q A;  4MY4 A;  1B8J A;  1KHK A;  4UPK A;  3WAY A;  1KHN A;  1KH7 A;  2W5R A;  3MK1 A; 
#chains in the Genus database with same CATH topology
 2GSO A;  4QAX A;  4CYR A;  1ALI A;  2GA3 A;  2W5X A;  4KM4 A;  3UN5 A;  4KJD A;  1Y6V A;  2W5S A;  2W5Q A;  3WAV A;  2IUC B;  3IDD A;  1ANJ A;  2ANH A;  3BDF A;  4LQY A;  4ZGA A;  5DLV A;  3TG0 A;  4NWX A;  1Y7A A;  2IUC A;  5TJ3 A;  2G9Y A;  1EI6 A;  1ELZ A;  2W5T A;  1E3C P;  4LRC A;  3WAW A;  3M7V A;  4N7T A;  1EQJ A;  4LRB A;  3UN2 A;  3A52 A;  4FDJ A;  4TN0 A;  1ELY A;  3BDG A;  3BDH A;  3OT9 A;  4LRA A;  5K4P A;  3TX0 A;  3SZY A;  5HRT A;  3MK2 A;  4LR8 A;  1KH9 A;  3T02 A;  3CMR A;  1AJC A;  1E33 P;  4B56 A;  1HJK A;  3KD8 A;  4KAV A;  4FDI A;  5DLT A;  3SZZ A;  3UNY A;  4GTW A;  3LXQ A;  2X98 A;  4UOO A;  1SHN A;  1ELX A;  4LRD A;  2W8S A;  1E2S P;  5L0K A;  1P49 A;  1KHL A;  2ZKT A;  3NKQ A;  1O98 A;  2QZU A;  5INH A;  5EGE A;  5L0E A;  4LRE A;  5GOV A;  1K7H A;  3M8W A;  3WAX A;  2RH6 A;  3NVL A;  1EW8 A;  1E1Z P;  3IGZ B;  1ZED A;  3TWZ A;  3DPC A;  4CXK A;  1ZEB A;  4NWJ A;  4UPL A;  1ALJ A;  4LR7 A;  5EGH A;  3NKO A;  3NKR A;  3NKN A;  1AJD A;  4ZG6 A;  1ALK A;  1ALH A;  5AJ9 A;  4GTX A;  1FSU A;  4YR1 A;  1N2K A;  2IFY A;  1KH4 A;  1KHJ A;  4LRF A;  1HDH A;  1EW2 A;  1URA A;  1KH5 A;  1SHQ A;  3BDG B;  4CYS A;  5LIA A;  5KXA A;  2GLQ A;  5LQQ A;  4GTY A;  1HQA A;  4UOR A;  2GSU A;  3T01 A;  3M8Y A;  1ED9 A;  4MIV A;  4LR2 A;  5IJQ A;  5GRR A;  2D1G A;  1AUK A;  3T00 A;  4UOP A;  3DYC A;  1O99 A;  2XR9 A;  5DLW A;  2XRG A;  4ZG7 A;  1URB A;  3IGY B;  3NKP A;  4UPH A;  2VQR A;  3UN3 A;  5C66 A;  4ZG9 A;  4LR9 A;  4CXS A;  3M8Z A;  1ED8 A;  3B5Q A;  1AJA A;  4KJG A;  2W5V A;  1ANI A;  3NKM A;  3E2D A;  3WBH A;  5IJS A;  1N2L A;  4UPI A;  1AJB A;  2W8D A;  3MK0 A;  5L0B A;  3UO0 A;  5LRM A;  1EJJ A;  4CXU A;  4MHX A;  1EW9 A;  3ED4 A;  4KAY A;  4GTZ A;  2GSN A;  2W5W A;  1ZEF A;  5LRN A;  3Q3Q A;  4MY4 A;  1B8J A;  1KHK A;  4UPK A;  3WAY A;  1KHN A;  1KH7 A;  2W5R A;  3MK1 A; 
#chains in the Genus database with same CATH homology
 2GSO A;  4QAX A;  4CYR A;  1ALI A;  2GA3 A;  2W5X A;  4KM4 A;  3UN5 A;  4KJD A;  1Y6V A;  2W5S A;  2W5Q A;  3WAV A;  2IUC B;  3IDD A;  1ANJ A;  2ANH A;  3BDF A;  4LQY A;  4ZGA A;  5DLV A;  3TG0 A;  4NWX A;  1Y7A A;  2IUC A;  5TJ3 A;  2G9Y A;  1EI6 A;  1ELZ A;  2W5T A;  1E3C P;  4LRC A;  3WAW A;  3M7V A;  4N7T A;  1EQJ A;  4LRB A;  3UN2 A;  3A52 A;  4FDJ A;  4TN0 A;  1ELY A;  3BDG A;  3BDH A;  3OT9 A;  4LRA A;  5K4P A;  3TX0 A;  3SZY A;  5HRT A;  3MK2 A;  4LR8 A;  1KH9 A;  3T02 A;  3CMR A;  1AJC A;  1E33 P;  4B56 A;  1HJK A;  3KD8 A;  4KAV A;  4FDI A;  5DLT A;  3SZZ A;  3UNY A;  4GTW A;  3LXQ A;  2X98 A;  4UOO A;  1SHN A;  1ELX A;  4LRD A;  2W8S A;  1E2S P;  5L0K A;  1P49 A;  1KHL A;  2ZKT A;  3NKQ A;  1O98 A;  2QZU A;  5INH A;  5EGE A;  5L0E A;  4LRE A;  5GOV A;  1K7H A;  3M8W A;  3WAX A;  2RH6 A;  3NVL A;  1EW8 A;  1E1Z P;  3IGZ B;  1ZED A;  3TWZ A;  3DPC A;  4CXK A;  1ZEB A;  4NWJ A;  4UPL A;  1ALJ A;  4LR7 A;  5EGH A;  3NKO A;  3NKR A;  3NKN A;  1AJD A;  4ZG6 A;  1ALK A;  1ALH A;  5AJ9 A;  4GTX A;  1FSU A;  4YR1 A;  1N2K A;  2IFY A;  1KH4 A;  1KHJ A;  4LRF A;  1HDH A;  1EW2 A;  1URA A;  1KH5 A;  1SHQ A;  3BDG B;  4CYS A;  5LIA A;  5KXA A;  2GLQ A;  5LQQ A;  4GTY A;  1HQA A;  4UOR A;  2GSU A;  3T01 A;  3M8Y A;  1ED9 A;  4MIV A;  4LR2 A;  5IJQ A;  5GRR A;  2D1G A;  1AUK A;  3T00 A;  4UOP A;  3DYC A;  1O99 A;  2XR9 A;  5DLW A;  2XRG A;  4ZG7 A;  1URB A;  3IGY B;  3NKP A;  4UPH A;  2VQR A;  3UN3 A;  5C66 A;  4ZG9 A;  4LR9 A;  4CXS A;  3M8Z A;  1ED8 A;  3B5Q A;  1AJA A;  4KJG A;  2W5V A;  1ANI A;  3NKM A;  3E2D A;  3WBH A;  5IJS A;  1N2L A;  4UPI A;  1AJB A;  2W8D A;  3MK0 A;  5L0B A;  3UO0 A;  5LRM A;  1EJJ A;  4CXU A;  4MHX A;  1EW9 A;  3ED4 A;  4KAY A;  4GTZ A;  2GSN A;  2W5W A;  1ZEF A;  5LRN A;  3Q3Q A;  4MY4 A;  1B8J A;  1KHK A;  4UPK A;  3WAY A;  1KHN A;  1KH7 A;  2W5R A;  3MK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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