3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
source organism Escherichia coli
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
3T00A 3NVLA 3NKOA 3NKPA 4LRDA 1E2SP 2W5QA 3WAVA 1KH7A 4YR1A 2GSNA 2W5VA 1AJDA 4CYRA 1HDHA 5INHA 1FSUA 4ZG7A 5L0EA 3E2DA 4KJDA 1URBA 1N2LA 3LXQA 4GTXA 1ANJA 1E1ZP 3T01A 5EGEA 2GLQA 5KXAA 1ED8A 1AJAA 1K7HA 3MK2A 2W8DA 4MY4A 4UOOA 1KH4A 2XR9A 1KHLA 4KAVA 1O98A 4LR9A 3TG0A 2XRGA 1O99A 2W5SA 3MK0A 1ALJA 5IJQA 1KH5A 3UNYA 5HRTA 1KH9A 4LR7A 4LREA 4TN0A 5GRRA 3UN3A 4UPKA 1Y7AA 4GTZA 1E33P 5EGHA 1ED9A 2W8SA 3B5QA 4LRBA 4N7TA 2GA3A 1HJKA 1ZEDA 1ALKA 5LIAA 1KHJA 3DYCA 3CMRA 3UN2A 1AJBA 4ZG6A 3TWZA 3WAWA 3KD8A 4UORA 4KM4A 2RH6A 3NKRA 3ED4A 4FDIA 1E3CP 1B8JA 3SZZA 3NKQA 5L0BA 3IDDA 3M8YA 5TJ3A 3UN5A 4CXKA 4LR8A 3T02A 3NKNA 3BDGB 4ZGAA 1ELXA 5IJSA 5LRNA 4MIVA 4LRAA 1KHNA 4UPHA 1ZEBA 5C66A 4CYSA 1SHQA 4KAYA 3A52A 5K4PA 2IUCB 3NKMA 4LRCA 3WBHA 5DLVA 3BDGA 2ZKTA 3WAXA 3WAYA 4UPIA 1HQAA 1EW8A 3BDFA 2QZUA 1EI6A 3UO0A 3MK1A 1EW2A 4FDJA 4CXUA 1ZEFA 2IUCA 1N2KA 5LRMA 2X98A 1EJJA 3OT9A 2W5XA 1ALIA 2G9YA 4B56A 2VQRA 4GTYA 5GOVA 1AJCA 4LRFA 4GTWA 1ELZA 3TX0A 1AUKA 4MHXA 3IGZB 4LQYA 3DPCA 2GSOA 4LR2A 1ALHA 1SHNA 2W5TA 1P49A 5DLWA 5L0KA 4UPLA 1EW9A 2ANHA 1URAA 2GSUA 1Y6VA 3Q3QA 1ANIA 2IFYA 1ELYA 1KHKA 3M7VA 1EQJA 4QAXA 5AJ9A 2W5RA 4NWJA 4CXSA 2D1GA 3SZYA 4UOPA 4NWXA 5DLTA 3BDHA 3IGYB 3M8WA 2W5WA 4KJGA 4ZG9A 5LQQA 3M8ZA
chains in the Genus database with same CATH superfamily
3T00A 3NVLA 3NKOA 3NKPA 4LRDA 1E2SP 2W5QA 3WAVA 1KH7A 4YR1A 2GSNA 2W5VA 1AJDA 4CYRA 1HDHA 5INHA 1FSUA 4ZG7A 5L0EA 3E2DA 4KJDA 1URBA 1N2LA 3LXQA 4GTXA 1ANJA 1E1ZP 3T01A 5EGEA 2GLQA 5KXAA 1ED8A 1AJAA 1K7HA 3MK2A 2W8DA 4MY4A 4UOOA 1KH4A 2XR9A 1KHLA 4KAVA 1O98A 4LR9A 3TG0A 2XRGA 1O99A 2W5SA 3MK0A 1ALJA 5IJQA 1KH5A 3UNYA 5HRTA 1KH9A 4LR7A 4LREA 4TN0A 5GRRA 3UN3A 4UPKA 1Y7AA 4GTZA 1E33P 5EGHA 1ED9A 2W8SA 3B5QA 4LRBA 4N7TA 2GA3A 1HJKA 1ZEDA 1ALKA 5LIAA 1KHJA 3DYCA 3CMRA 3UN2A 1AJBA 4ZG6A 3TWZA 3WAWA 3KD8A 4UORA 4KM4A 2RH6A 3NKRA 3ED4A 4FDIA 1E3CP 1B8JA 3SZZA 3NKQA 5L0BA 3IDDA 3M8YA 5TJ3A 3UN5A 4CXKA 4LR8A 3T02A 3NKNA 3BDGB 4ZGAA 1ELXA 5IJSA 5LRNA 4MIVA 4LRAA 1KHNA 4UPHA 1ZEBA 5C66A 4CYSA 1SHQA 4KAYA 3A52A 5K4PA 2IUCB 3NKMA 4LRCA 3WBHA 5DLVA 3BDGA 2ZKTA 3WAXA 3WAYA 4UPIA 1HQAA 1EW8A 3BDFA 2QZUA 1EI6A 3UO0A 3MK1A 1EW2A 4FDJA 4CXUA 1ZEFA 2IUCA 1N2KA 5LRMA 2X98A 1EJJA 3OT9A 2W5XA 1ALIA 2G9YA 4B56A 2VQRA 4GTYA 5GOVA 1AJCA 4LRFA 4GTWA 1ELZA 3TX0A 1AUKA 4MHXA 3IGZB 4LQYA 3DPCA 2GSOA 4LR2A 1ALHA 1SHNA 2W5TA 1P49A 5DLWA 5L0KA 4UPLA 1EW9A 2ANHA 1URAA 2GSUA 1Y6VA 3Q3QA 1ANIA 2IFYA 1ELYA 1KHKA 3M7VA 1EQJA 4QAXA 5AJ9A 2W5RA 4NWJA 4CXSA 2D1GA 3SZYA 4UOPA 4NWXA 5DLTA 3BDHA 3IGYB 3M8WA 2W5WA 4KJGA 4ZG9A 5LQQA 3M8ZA
chains in the Genus database with same CATH topology
3T00A 3NVLA 3NKOA 3NKPA 4LRDA 1E2SP 2W5QA 3WAVA 1KH7A 4YR1A 2GSNA 2W5VA 1AJDA 4CYRA 1HDHA 5INHA 1FSUA 4ZG7A 5L0EA 3E2DA 4KJDA 1URBA 1N2LA 3LXQA 4GTXA 1ANJA 1E1ZP 3T01A 5EGEA 2GLQA 5KXAA 1ED8A 1AJAA 1K7HA 3MK2A 2W8DA 4MY4A 4UOOA 1KH4A 2XR9A 1KHLA 4KAVA 1O98A 4LR9A 3TG0A 2XRGA 1O99A 2W5SA 3MK0A 1ALJA 5IJQA 1KH5A 3UNYA 5HRTA 1KH9A 4LR7A 4LREA 4TN0A 5GRRA 3UN3A 4UPKA 1Y7AA 4GTZA 1E33P 5EGHA 1ED9A 2W8SA 3B5QA 4LRBA 4N7TA 2GA3A 1HJKA 1ZEDA 1ALKA 5LIAA 1KHJA 3DYCA 3CMRA 3UN2A 1AJBA 4ZG6A 3TWZA 3WAWA 3KD8A 4UORA 4KM4A 2RH6A 3NKRA 3ED4A 4FDIA 1E3CP 1B8JA 3SZZA 3NKQA 5L0BA 3IDDA 3M8YA 5TJ3A 3UN5A 4CXKA 4LR8A 3T02A 3NKNA 3BDGB 4ZGAA 1ELXA 5IJSA 5LRNA 4MIVA 4LRAA 1KHNA 4UPHA 1ZEBA 5C66A 4CYSA 1SHQA 4KAYA 3A52A 5K4PA 2IUCB 3NKMA 4LRCA 3WBHA 5DLVA 3BDGA 2ZKTA 3WAXA 3WAYA 4UPIA 1HQAA 1EW8A 3BDFA 2QZUA 1EI6A 3UO0A 3MK1A 1EW2A 4FDJA 4CXUA 1ZEFA 2IUCA 1N2KA 5LRMA 2X98A 1EJJA 3OT9A 2W5XA 1ALIA 2G9YA 4B56A 2VQRA 4GTYA 5GOVA 1AJCA 4LRFA 4GTWA 1ELZA 3TX0A 1AUKA 4MHXA 3IGZB 4LQYA 3DPCA 2GSOA 4LR2A 1ALHA 1SHNA 2W5TA 1P49A 5DLWA 5L0KA 4UPLA 1EW9A 2ANHA 1URAA 2GSUA 1Y6VA 3Q3QA 1ANIA 2IFYA 1ELYA 1KHKA 3M7VA 1EQJA 4QAXA 5AJ9A 2W5RA 4NWJA 4CXSA 2D1GA 3SZYA 4UOPA 4NWXA 5DLTA 3BDHA 3IGYB 3M8WA 2W5WA 4KJGA 4ZG9A 5LQQA 3M8ZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T00 A;  3NVL A;  3NKO A;  3NKP A;  4LRD A;  1E2S P;  2W5Q A;  3WAV A;  1KH7 A;  4YR1 A;  2GSN A;  2W5V A;  1AJD A;  4CYR A;  1HDH A;  5INH A;  1FSU A;  4ZG7 A;  5L0E A;  3E2D A;  4KJD A;  1URB A;  1N2L A;  3LXQ A;  4GTX A;  1ANJ A;  1E1Z P;  3T01 A;  5EGE A;  2GLQ A;  5KXA A;  1ED8 A;  1AJA A;  1K7H A;  3MK2 A;  2W8D A;  4MY4 A;  4UOO A;  1KH4 A;  2XR9 A;  1KHL A;  4KAV A;  1O98 A;  4LR9 A;  3TG0 A;  2XRG A;  1O99 A;  2W5S A;  3MK0 A;  1ALJ A;  5IJQ A;  1KH5 A;  3UNY A;  5HRT A;  1KH9 A;  4LR7 A;  4LRE A;  4TN0 A;  5GRR A;  3UN3 A;  4UPK A;  1Y7A A;  4GTZ A;  1E33 P;  5EGH A;  1ED9 A;  2W8S A;  3B5Q A;  4LRB A;  4N7T A;  2GA3 A;  1HJK A;  1ZED A;  1ALK A;  5LIA A;  1KHJ A;  3DYC A;  3CMR A;  3UN2 A;  1AJB A;  4ZG6 A;  3TWZ A;  3WAW A;  3KD8 A;  4UOR A;  4KM4 A;  2RH6 A;  3NKR A;  3ED4 A;  4FDI A;  1E3C P;  1B8J A;  3SZZ A;  3NKQ A;  5L0B A;  3IDD A;  3M8Y A;  5TJ3 A;  3UN5 A;  4CXK A;  4LR8 A;  3T02 A;  3NKN A;  3BDG B;  4ZGA A;  1ELX A;  5IJS A;  5LRN A;  4MIV A;  4LRA A;  1KHN A;  4UPH A;  1ZEB A;  5C66 A;  4CYS A;  1SHQ A;  4KAY A;  3A52 A;  5K4P A;  2IUC B;  3NKM A;  4LRC A;  3WBH A;  5DLV A;  3BDG A;  2ZKT A;  3WAX A;  3WAY A;  4UPI A;  1HQA A;  1EW8 A;  3BDF A;  2QZU A;  1EI6 A;  3UO0 A;  3MK1 A;  1EW2 A;  4FDJ A;  4CXU A;  1ZEF A;  2IUC A;  1N2K A;  5LRM A;  2X98 A;  1EJJ A;  3OT9 A;  2W5X A;  1ALI A;  2G9Y A;  4B56 A;  2VQR A;  4GTY A;  5GOV A;  1AJC A;  4LRF A;  4GTW A;  1ELZ A;  3TX0 A;  1AUK A;  4MHX A;  3IGZ B;  4LQY A;  3DPC A;  2GSO A;  4LR2 A;  1ALH A;  1SHN A;  2W5T A;  1P49 A;  5DLW A;  5L0K A;  4UPL A;  1EW9 A;  2ANH A;  1URA A;  2GSU A;  1Y6V A;  3Q3Q A;  1ANI A;  2IFY A;  1ELY A;  1KHK A;  3M7V A;  1EQJ A;  4QAX A;  5AJ9 A;  2W5R A;  4NWJ A;  4CXS A;  2D1G A;  3SZY A;  4UOP A;  4NWX A;  5DLT A;  3BDH A;  3IGY B;  3M8W A;  2W5W A;  4KJG A;  4ZG9 A;  5LQQ A;  3M8Z A; 
#chains in the Genus database with same CATH topology
 3T00 A;  3NVL A;  3NKO A;  3NKP A;  4LRD A;  1E2S P;  2W5Q A;  3WAV A;  1KH7 A;  4YR1 A;  2GSN A;  2W5V A;  1AJD A;  4CYR A;  1HDH A;  5INH A;  1FSU A;  4ZG7 A;  5L0E A;  3E2D A;  4KJD A;  1URB A;  1N2L A;  3LXQ A;  4GTX A;  1ANJ A;  1E1Z P;  3T01 A;  5EGE A;  2GLQ A;  5KXA A;  1ED8 A;  1AJA A;  1K7H A;  3MK2 A;  2W8D A;  4MY4 A;  4UOO A;  1KH4 A;  2XR9 A;  1KHL A;  4KAV A;  1O98 A;  4LR9 A;  3TG0 A;  2XRG A;  1O99 A;  2W5S A;  3MK0 A;  1ALJ A;  5IJQ A;  1KH5 A;  3UNY A;  5HRT A;  1KH9 A;  4LR7 A;  4LRE A;  4TN0 A;  5GRR A;  3UN3 A;  4UPK A;  1Y7A A;  4GTZ A;  1E33 P;  5EGH A;  1ED9 A;  2W8S A;  3B5Q A;  4LRB A;  4N7T A;  2GA3 A;  1HJK A;  1ZED A;  1ALK A;  5LIA A;  1KHJ A;  3DYC A;  3CMR A;  3UN2 A;  1AJB A;  4ZG6 A;  3TWZ A;  3WAW A;  3KD8 A;  4UOR A;  4KM4 A;  2RH6 A;  3NKR A;  3ED4 A;  4FDI A;  1E3C P;  1B8J A;  3SZZ A;  3NKQ A;  5L0B A;  3IDD A;  3M8Y A;  5TJ3 A;  3UN5 A;  4CXK A;  4LR8 A;  3T02 A;  3NKN A;  3BDG B;  4ZGA A;  1ELX A;  5IJS A;  5LRN A;  4MIV A;  4LRA A;  1KHN A;  4UPH A;  1ZEB A;  5C66 A;  4CYS A;  1SHQ A;  4KAY A;  3A52 A;  5K4P A;  2IUC B;  3NKM A;  4LRC A;  3WBH A;  5DLV A;  3BDG A;  2ZKT A;  3WAX A;  3WAY A;  4UPI A;  1HQA A;  1EW8 A;  3BDF A;  2QZU A;  1EI6 A;  3UO0 A;  3MK1 A;  1EW2 A;  4FDJ A;  4CXU A;  1ZEF A;  2IUC A;  1N2K A;  5LRM A;  2X98 A;  1EJJ A;  3OT9 A;  2W5X A;  1ALI A;  2G9Y A;  4B56 A;  2VQR A;  4GTY A;  5GOV A;  1AJC A;  4LRF A;  4GTW A;  1ELZ A;  3TX0 A;  1AUK A;  4MHX A;  3IGZ B;  4LQY A;  3DPC A;  2GSO A;  4LR2 A;  1ALH A;  1SHN A;  2W5T A;  1P49 A;  5DLW A;  5L0K A;  4UPL A;  1EW9 A;  2ANH A;  1URA A;  2GSU A;  1Y6V A;  3Q3Q A;  1ANI A;  2IFY A;  1ELY A;  1KHK A;  3M7V A;  1EQJ A;  4QAX A;  5AJ9 A;  2W5R A;  4NWJ A;  4CXS A;  2D1G A;  3SZY A;  4UOP A;  4NWX A;  5DLT A;  3BDH A;  3IGY B;  3M8W A;  2W5W A;  4KJG A;  4ZG9 A;  5LQQ A;  3M8Z A; 
#chains in the Genus database with same CATH homology
 3T00 A;  3NVL A;  3NKO A;  3NKP A;  4LRD A;  1E2S P;  2W5Q A;  3WAV A;  1KH7 A;  4YR1 A;  2GSN A;  2W5V A;  1AJD A;  4CYR A;  1HDH A;  5INH A;  1FSU A;  4ZG7 A;  5L0E A;  3E2D A;  4KJD A;  1URB A;  1N2L A;  3LXQ A;  4GTX A;  1ANJ A;  1E1Z P;  3T01 A;  5EGE A;  2GLQ A;  5KXA A;  1ED8 A;  1AJA A;  1K7H A;  3MK2 A;  2W8D A;  4MY4 A;  4UOO A;  1KH4 A;  2XR9 A;  1KHL A;  4KAV A;  1O98 A;  4LR9 A;  3TG0 A;  2XRG A;  1O99 A;  2W5S A;  3MK0 A;  1ALJ A;  5IJQ A;  1KH5 A;  3UNY A;  5HRT A;  1KH9 A;  4LR7 A;  4LRE A;  4TN0 A;  5GRR A;  3UN3 A;  4UPK A;  1Y7A A;  4GTZ A;  1E33 P;  5EGH A;  1ED9 A;  2W8S A;  3B5Q A;  4LRB A;  4N7T A;  2GA3 A;  1HJK A;  1ZED A;  1ALK A;  5LIA A;  1KHJ A;  3DYC A;  3CMR A;  3UN2 A;  1AJB A;  4ZG6 A;  3TWZ A;  3WAW A;  3KD8 A;  4UOR A;  4KM4 A;  2RH6 A;  3NKR A;  3ED4 A;  4FDI A;  1E3C P;  1B8J A;  3SZZ A;  3NKQ A;  5L0B A;  3IDD A;  3M8Y A;  5TJ3 A;  3UN5 A;  4CXK A;  4LR8 A;  3T02 A;  3NKN A;  3BDG B;  4ZGA A;  1ELX A;  5IJS A;  5LRN A;  4MIV A;  4LRA A;  1KHN A;  4UPH A;  1ZEB A;  5C66 A;  4CYS A;  1SHQ A;  4KAY A;  3A52 A;  5K4P A;  2IUC B;  3NKM A;  4LRC A;  3WBH A;  5DLV A;  3BDG A;  2ZKT A;  3WAX A;  3WAY A;  4UPI A;  1HQA A;  1EW8 A;  3BDF A;  2QZU A;  1EI6 A;  3UO0 A;  3MK1 A;  1EW2 A;  4FDJ A;  4CXU A;  1ZEF A;  2IUC A;  1N2K A;  5LRM A;  2X98 A;  1EJJ A;  3OT9 A;  2W5X A;  1ALI A;  2G9Y A;  4B56 A;  2VQR A;  4GTY A;  5GOV A;  1AJC A;  4LRF A;  4GTW A;  1ELZ A;  3TX0 A;  1AUK A;  4MHX A;  3IGZ B;  4LQY A;  3DPC A;  2GSO A;  4LR2 A;  1ALH A;  1SHN A;  2W5T A;  1P49 A;  5DLW A;  5L0K A;  4UPL A;  1EW9 A;  2ANH A;  1URA A;  2GSU A;  1Y6V A;  3Q3Q A;  1ANI A;  2IFY A;  1ELY A;  1KHK A;  3M7V A;  1EQJ A;  4QAX A;  5AJ9 A;  2W5R A;  4NWJ A;  4CXS A;  2D1G A;  3SZY A;  4UOP A;  4NWX A;  5DLT A;  3BDH A;  3IGY B;  3M8W A;  2W5W A;  4KJG A;  4ZG9 A;  5LQQ A;  3M8Z A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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