3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
5IJSA 3BDFA 4ZG9A 5L0EA 3TG0A 1P49A 2GSOA 3MK0A 1ED9A 3M8YA 3OT9A 3TWZA 2ANHA 2GSUA 4KJDA 1HJKA 2GA3A 5INHA 1AJDA 5HRTA 5EGHA 5L0BA 1ZEFA 4LR9A 3T01A 3NVLA 1N2KA 1ELYA 3B5QA 4KM4A 2VQRA 1HDHA 5DLVA 5DLTA 2W5QA 3Q3QA 4MY4A 4UOOA 5AJ9A 2GSNA 3T00A 3MK1A 3BDGB 3UNYA 3E2DA 4KAYA 1E33P 3UN3A 5LIAA 1ALKA 5GRRA 3NKOA 3UN2A 4KAVA 4MIVA 3NKMA 4CXSA 1AJBA 4B56A 3T02A 4NWJA 3TX0A 1E2SP 2W5WA 2G9YA 1AJCA 3UN5A 2X98A 2IUCB 4LRFA 3SZYA 1KH7A 2W8DA 3WAYA 1AUKA 1KHNA 1ANJA 4CYSA 1EQJA 5LRNA 1ZEDA 3BDGA 4LRDA 4GTWA 5KXAA 1ALHA 1EW9A 1KHKA 3NKNA 3IGZB 5IJQA 2GLQA 4CXKA 4KJGA 4FDIA 5GOVA 4LRCA 2W5TA 1SHNA 1EW8A 4GTYA 3WBHA 1ALJA 1N2LA 2W8SA 2QZUA 4LR8A 1URAA 5EGEA 4UPIA 1EI6A 3WAXA 3WAVA 1ANIA 1Y7AA 1O99A 3CMRA 5LRMA 1FSUA 4QAXA 4UOPA 1HQAA 3M8ZA 4FDJA 1E1ZP 3NKRA 4LREA 1EJJA 1ED8A 2XR9A 2D1GA 4GTXA 1EW2A 4UPKA 2IUCA 4UPHA 4TN0A 3NKQA 4LQYA 3LXQA 4YR1A 4ZG6A 2W5RA 4LR2A 2W5SA 4UPLA 1ZEBA 5C66A 3DYCA 3MK2A 4LRBA 5DLWA 1ELXA 2W5VA 3UO0A 5TJ3A 3WAWA 3ED4A 1KH5A 4LR7A 4GTZA 4MHXA 1KHLA 1URBA 3IGYB 4LRAA 4CXUA 1ALIA 5K4PA 1KHJA 4CYRA 1E3CP 4ZG7A 3IDDA 2IFYA 2RH6A 1KH9A 1O98A 4N7TA 4NWXA 3BDHA 2W5XA 5L0KA 3M8WA 1B8JA 1AJAA 3SZZA 3NKPA 3A52A 2ZKTA 1K7HA 1KH4A 4UORA 3KD8A 1ELZA 5LQQA 3M7VA 1SHQA 2XRGA 4ZGAA 1Y6VA 3DPCA
chains in the Genus database with same CATH superfamily
5IJSA 3BDFA 4ZG9A 5L0EA 3TG0A 1P49A 2GSOA 3MK0A 1ED9A 3M8YA 3OT9A 3TWZA 2ANHA 2GSUA 4KJDA 1HJKA 2GA3A 5INHA 1AJDA 5HRTA 5EGHA 5L0BA 1ZEFA 4LR9A 3T01A 3NVLA 1N2KA 1ELYA 3B5QA 4KM4A 2VQRA 1HDHA 5DLVA 5DLTA 2W5QA 3Q3QA 4MY4A 4UOOA 5AJ9A 2GSNA 3T00A 3MK1A 3BDGB 3UNYA 3E2DA 4KAYA 1E33P 3UN3A 5LIAA 1ALKA 5GRRA 3NKOA 3UN2A 4KAVA 4MIVA 3NKMA 4CXSA 1AJBA 4B56A 3T02A 4NWJA 3TX0A 1E2SP 2W5WA 2G9YA 1AJCA 3UN5A 2X98A 2IUCB 4LRFA 3SZYA 1KH7A 2W8DA 3WAYA 1AUKA 1KHNA 1ANJA 4CYSA 1EQJA 5LRNA 1ZEDA 3BDGA 4LRDA 4GTWA 5KXAA 1ALHA 1EW9A 1KHKA 3NKNA 3IGZB 5IJQA 2GLQA 4CXKA 4KJGA 4FDIA 5GOVA 4LRCA 2W5TA 1SHNA 1EW8A 4GTYA 3WBHA 1ALJA 1N2LA 2W8SA 2QZUA 4LR8A 1URAA 5EGEA 4UPIA 1EI6A 3WAXA 3WAVA 1ANIA 1Y7AA 1O99A 3CMRA 5LRMA 1FSUA 4QAXA 4UOPA 1HQAA 3M8ZA 4FDJA 1E1ZP 3NKRA 4LREA 1EJJA 1ED8A 2XR9A 2D1GA 4GTXA 1EW2A 4UPKA 2IUCA 4UPHA 4TN0A 3NKQA 4LQYA 3LXQA 4YR1A 4ZG6A 2W5RA 4LR2A 2W5SA 4UPLA 1ZEBA 5C66A 3DYCA 3MK2A 4LRBA 5DLWA 1ELXA 2W5VA 3UO0A 5TJ3A 3WAWA 3ED4A 1KH5A 4LR7A 4GTZA 4MHXA 1KHLA 1URBA 3IGYB 4LRAA 4CXUA 1ALIA 5K4PA 1KHJA 4CYRA 1E3CP 4ZG7A 3IDDA 2IFYA 2RH6A 1KH9A 1O98A 4N7TA 4NWXA 3BDHA 2W5XA 5L0KA 3M8WA 1B8JA 1AJAA 3SZZA 3NKPA 3A52A 2ZKTA 1K7HA 1KH4A 4UORA 3KD8A 1ELZA 5LQQA 3M7VA 1SHQA 2XRGA 4ZGAA 1Y6VA 3DPCA
chains in the Genus database with same CATH topology
5IJSA 3BDFA 4ZG9A 5L0EA 3TG0A 1P49A 2GSOA 3MK0A 1ED9A 3M8YA 3OT9A 3TWZA 2ANHA 2GSUA 4KJDA 1HJKA 2GA3A 5INHA 1AJDA 5HRTA 5EGHA 5L0BA 1ZEFA 4LR9A 3T01A 3NVLA 1N2KA 1ELYA 3B5QA 4KM4A 2VQRA 1HDHA 5DLVA 5DLTA 2W5QA 3Q3QA 4MY4A 4UOOA 5AJ9A 2GSNA 3T00A 3MK1A 3BDGB 3UNYA 3E2DA 4KAYA 1E33P 3UN3A 5LIAA 1ALKA 5GRRA 3NKOA 3UN2A 4KAVA 4MIVA 3NKMA 4CXSA 1AJBA 4B56A 3T02A 4NWJA 3TX0A 1E2SP 2W5WA 2G9YA 1AJCA 3UN5A 2X98A 2IUCB 4LRFA 3SZYA 1KH7A 2W8DA 3WAYA 1AUKA 1KHNA 1ANJA 4CYSA 1EQJA 5LRNA 1ZEDA 3BDGA 4LRDA 4GTWA 5KXAA 1ALHA 1EW9A 1KHKA 3NKNA 3IGZB 5IJQA 2GLQA 4CXKA 4KJGA 4FDIA 5GOVA 4LRCA 2W5TA 1SHNA 1EW8A 4GTYA 3WBHA 1ALJA 1N2LA 2W8SA 2QZUA 4LR8A 1URAA 5EGEA 4UPIA 1EI6A 3WAXA 3WAVA 1ANIA 1Y7AA 1O99A 3CMRA 5LRMA 1FSUA 4QAXA 4UOPA 1HQAA 3M8ZA 4FDJA 1E1ZP 3NKRA 4LREA 1EJJA 1ED8A 2XR9A 2D1GA 4GTXA 1EW2A 4UPKA 2IUCA 4UPHA 4TN0A 3NKQA 4LQYA 3LXQA 4YR1A 4ZG6A 2W5RA 4LR2A 2W5SA 4UPLA 1ZEBA 5C66A 3DYCA 3MK2A 4LRBA 5DLWA 1ELXA 2W5VA 3UO0A 5TJ3A 3WAWA 3ED4A 1KH5A 4LR7A 4GTZA 4MHXA 1KHLA 1URBA 3IGYB 4LRAA 4CXUA 1ALIA 5K4PA 1KHJA 4CYRA 1E3CP 4ZG7A 3IDDA 2IFYA 2RH6A 1KH9A 1O98A 4N7TA 4NWXA 3BDHA 2W5XA 5L0KA 3M8WA 1B8JA 1AJAA 3SZZA 3NKPA 3A52A 2ZKTA 1K7HA 1KH4A 4UORA 3KD8A 1ELZA 5LQQA 3M7VA 1SHQA 2XRGA 4ZGAA 1Y6VA 3DPCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5IJS A;  3BDF A;  4ZG9 A;  5L0E A;  3TG0 A;  1P49 A;  2GSO A;  3MK0 A;  1ED9 A;  3M8Y A;  3OT9 A;  3TWZ A;  2ANH A;  2GSU A;  4KJD A;  1HJK A;  2GA3 A;  5INH A;  1AJD A;  5HRT A;  5EGH A;  5L0B A;  1ZEF A;  4LR9 A;  3T01 A;  3NVL A;  1N2K A;  1ELY A;  3B5Q A;  4KM4 A;  2VQR A;  1HDH A;  5DLV A;  5DLT A;  2W5Q A;  3Q3Q A;  4MY4 A;  4UOO A;  5AJ9 A;  2GSN A;  3T00 A;  3MK1 A;  3BDG B;  3UNY A;  3E2D A;  4KAY A;  1E33 P;  3UN3 A;  5LIA A;  1ALK A;  5GRR A;  3NKO A;  3UN2 A;  4KAV A;  4MIV A;  3NKM A;  4CXS A;  1AJB A;  4B56 A;  3T02 A;  4NWJ A;  3TX0 A;  1E2S P;  2W5W A;  2G9Y A;  1AJC A;  3UN5 A;  2X98 A;  2IUC B;  4LRF A;  3SZY A;  1KH7 A;  2W8D A;  3WAY A;  1AUK A;  1KHN A;  1ANJ A;  4CYS A;  1EQJ A;  5LRN A;  1ZED A;  3BDG A;  4LRD A;  4GTW A;  5KXA A;  1ALH A;  1EW9 A;  1KHK A;  3NKN A;  3IGZ B;  5IJQ A;  2GLQ A;  4CXK A;  4KJG A;  4FDI A;  5GOV A;  4LRC A;  2W5T A;  1SHN A;  1EW8 A;  4GTY A;  3WBH A;  1ALJ A;  1N2L A;  2W8S A;  2QZU A;  4LR8 A;  1URA A;  5EGE A;  4UPI A;  1EI6 A;  3WAX A;  3WAV A;  1ANI A;  1Y7A A;  1O99 A;  3CMR A;  5LRM A;  1FSU A;  4QAX A;  4UOP A;  1HQA A;  3M8Z A;  4FDJ A;  1E1Z P;  3NKR A;  4LRE A;  1EJJ A;  1ED8 A;  2XR9 A;  2D1G A;  4GTX A;  1EW2 A;  4UPK A;  2IUC A;  4UPH A;  4TN0 A;  3NKQ A;  4LQY A;  3LXQ A;  4YR1 A;  4ZG6 A;  2W5R A;  4LR2 A;  2W5S A;  4UPL A;  1ZEB A;  5C66 A;  3DYC A;  3MK2 A;  4LRB A;  5DLW A;  1ELX A;  2W5V A;  3UO0 A;  5TJ3 A;  3WAW A;  3ED4 A;  1KH5 A;  4LR7 A;  4GTZ A;  4MHX A;  1KHL A;  1URB A;  3IGY B;  4LRA A;  4CXU A;  1ALI A;  5K4P A;  1KHJ A;  4CYR A;  1E3C P;  4ZG7 A;  3IDD A;  2IFY A;  2RH6 A;  1KH9 A;  1O98 A;  4N7T A;  4NWX A;  3BDH A;  2W5X A;  5L0K A;  3M8W A;  1B8J A;  1AJA A;  3SZZ A;  3NKP A;  3A52 A;  2ZKT A;  1K7H A;  1KH4 A;  4UOR A;  3KD8 A;  1ELZ A;  5LQQ A;  3M7V A;  1SHQ A;  2XRG A;  4ZGA A;  1Y6V A;  3DPC A; 
#chains in the Genus database with same CATH topology
 5IJS A;  3BDF A;  4ZG9 A;  5L0E A;  3TG0 A;  1P49 A;  2GSO A;  3MK0 A;  1ED9 A;  3M8Y A;  3OT9 A;  3TWZ A;  2ANH A;  2GSU A;  4KJD A;  1HJK A;  2GA3 A;  5INH A;  1AJD A;  5HRT A;  5EGH A;  5L0B A;  1ZEF A;  4LR9 A;  3T01 A;  3NVL A;  1N2K A;  1ELY A;  3B5Q A;  4KM4 A;  2VQR A;  1HDH A;  5DLV A;  5DLT A;  2W5Q A;  3Q3Q A;  4MY4 A;  4UOO A;  5AJ9 A;  2GSN A;  3T00 A;  3MK1 A;  3BDG B;  3UNY A;  3E2D A;  4KAY A;  1E33 P;  3UN3 A;  5LIA A;  1ALK A;  5GRR A;  3NKO A;  3UN2 A;  4KAV A;  4MIV A;  3NKM A;  4CXS A;  1AJB A;  4B56 A;  3T02 A;  4NWJ A;  3TX0 A;  1E2S P;  2W5W A;  2G9Y A;  1AJC A;  3UN5 A;  2X98 A;  2IUC B;  4LRF A;  3SZY A;  1KH7 A;  2W8D A;  3WAY A;  1AUK A;  1KHN A;  1ANJ A;  4CYS A;  1EQJ A;  5LRN A;  1ZED A;  3BDG A;  4LRD A;  4GTW A;  5KXA A;  1ALH A;  1EW9 A;  1KHK A;  3NKN A;  3IGZ B;  5IJQ A;  2GLQ A;  4CXK A;  4KJG A;  4FDI A;  5GOV A;  4LRC A;  2W5T A;  1SHN A;  1EW8 A;  4GTY A;  3WBH A;  1ALJ A;  1N2L A;  2W8S A;  2QZU A;  4LR8 A;  1URA A;  5EGE A;  4UPI A;  1EI6 A;  3WAX A;  3WAV A;  1ANI A;  1Y7A A;  1O99 A;  3CMR A;  5LRM A;  1FSU A;  4QAX A;  4UOP A;  1HQA A;  3M8Z A;  4FDJ A;  1E1Z P;  3NKR A;  4LRE A;  1EJJ A;  1ED8 A;  2XR9 A;  2D1G A;  4GTX A;  1EW2 A;  4UPK A;  2IUC A;  4UPH A;  4TN0 A;  3NKQ A;  4LQY A;  3LXQ A;  4YR1 A;  4ZG6 A;  2W5R A;  4LR2 A;  2W5S A;  4UPL A;  1ZEB A;  5C66 A;  3DYC A;  3MK2 A;  4LRB A;  5DLW A;  1ELX A;  2W5V A;  3UO0 A;  5TJ3 A;  3WAW A;  3ED4 A;  1KH5 A;  4LR7 A;  4GTZ A;  4MHX A;  1KHL A;  1URB A;  3IGY B;  4LRA A;  4CXU A;  1ALI A;  5K4P A;  1KHJ A;  4CYR A;  1E3C P;  4ZG7 A;  3IDD A;  2IFY A;  2RH6 A;  1KH9 A;  1O98 A;  4N7T A;  4NWX A;  3BDH A;  2W5X A;  5L0K A;  3M8W A;  1B8J A;  1AJA A;  3SZZ A;  3NKP A;  3A52 A;  2ZKT A;  1K7H A;  1KH4 A;  4UOR A;  3KD8 A;  1ELZ A;  5LQQ A;  3M7V A;  1SHQ A;  2XRG A;  4ZGA A;  1Y6V A;  3DPC A; 
#chains in the Genus database with same CATH homology
 5IJS A;  3BDF A;  4ZG9 A;  5L0E A;  3TG0 A;  1P49 A;  2GSO A;  3MK0 A;  1ED9 A;  3M8Y A;  3OT9 A;  3TWZ A;  2ANH A;  2GSU A;  4KJD A;  1HJK A;  2GA3 A;  5INH A;  1AJD A;  5HRT A;  5EGH A;  5L0B A;  1ZEF A;  4LR9 A;  3T01 A;  3NVL A;  1N2K A;  1ELY A;  3B5Q A;  4KM4 A;  2VQR A;  1HDH A;  5DLV A;  5DLT A;  2W5Q A;  3Q3Q A;  4MY4 A;  4UOO A;  5AJ9 A;  2GSN A;  3T00 A;  3MK1 A;  3BDG B;  3UNY A;  3E2D A;  4KAY A;  1E33 P;  3UN3 A;  5LIA A;  1ALK A;  5GRR A;  3NKO A;  3UN2 A;  4KAV A;  4MIV A;  3NKM A;  4CXS A;  1AJB A;  4B56 A;  3T02 A;  4NWJ A;  3TX0 A;  1E2S P;  2W5W A;  2G9Y A;  1AJC A;  3UN5 A;  2X98 A;  2IUC B;  4LRF A;  3SZY A;  1KH7 A;  2W8D A;  3WAY A;  1AUK A;  1KHN A;  1ANJ A;  4CYS A;  1EQJ A;  5LRN A;  1ZED A;  3BDG A;  4LRD A;  4GTW A;  5KXA A;  1ALH A;  1EW9 A;  1KHK A;  3NKN A;  3IGZ B;  5IJQ A;  2GLQ A;  4CXK A;  4KJG A;  4FDI A;  5GOV A;  4LRC A;  2W5T A;  1SHN A;  1EW8 A;  4GTY A;  3WBH A;  1ALJ A;  1N2L A;  2W8S A;  2QZU A;  4LR8 A;  1URA A;  5EGE A;  4UPI A;  1EI6 A;  3WAX A;  3WAV A;  1ANI A;  1Y7A A;  1O99 A;  3CMR A;  5LRM A;  1FSU A;  4QAX A;  4UOP A;  1HQA A;  3M8Z A;  4FDJ A;  1E1Z P;  3NKR A;  4LRE A;  1EJJ A;  1ED8 A;  2XR9 A;  2D1G A;  4GTX A;  1EW2 A;  4UPK A;  2IUC A;  4UPH A;  4TN0 A;  3NKQ A;  4LQY A;  3LXQ A;  4YR1 A;  4ZG6 A;  2W5R A;  4LR2 A;  2W5S A;  4UPL A;  1ZEB A;  5C66 A;  3DYC A;  3MK2 A;  4LRB A;  5DLW A;  1ELX A;  2W5V A;  3UO0 A;  5TJ3 A;  3WAW A;  3ED4 A;  1KH5 A;  4LR7 A;  4GTZ A;  4MHX A;  1KHL A;  1URB A;  3IGY B;  4LRA A;  4CXU A;  1ALI A;  5K4P A;  1KHJ A;  4CYR A;  1E3C P;  4ZG7 A;  3IDD A;  2IFY A;  2RH6 A;  1KH9 A;  1O98 A;  4N7T A;  4NWX A;  3BDH A;  2W5X A;  5L0K A;  3M8W A;  1B8J A;  1AJA A;  3SZZ A;  3NKP A;  3A52 A;  2ZKT A;  1K7H A;  1KH4 A;  4UOR A;  3KD8 A;  1ELZ A;  5LQQ A;  3M7V A;  1SHQ A;  2XRG A;  4ZGA A;  1Y6V A;  3DPC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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