3CMRA

E. coli alkaline phosphatase mutant r166s in complex with phosphate
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
Knots found
sequence length
445
structure length
445
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSSKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Arginine coordination in enzymatic phosphoryl transfer: evaluation of the effect of Arg166 mutations in Escherichia coli alkaline phosphatase
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 164
structure length 445
sequence length 445
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2008-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3cmrA00
1O99A 1SHNA 2IUCB 3BDHA 3E2DA 1ZEFA 1E2SP 1KH5A 1KHLA 3CMRA 3IGYB 3M7VA 1AJBA 3M8YA 3B5QA 1KH7A 5LQQA 1KHJA 1ZEDA 5TJ3A 2XRGA 1AJAA 4LRCA 4LRFA 3UN3A 4GTWA 4ZG9A 3WAVA 1E3CP 4TN0A 1AJDA 1K7HA 2ZKTA 2VQRA 1EW8A 1KHNA 4KJDA 4KJGA 4UORA 5INHA 4FDIA 3BDFA 4FDJA 3WAWA 3KD8A 3NKNA 2GA3A 2G9YA 2RH6A 2W5XA 3DYCA 3UN2A 4ZG6A 1FSUA 4B56A 4GTXA 4LR7A 4NWJA 3UNYA 2W5VA 1HQAA 3BDGB 3OT9A 3T01A 3WBHA 5LRNA 2X98A 5LIAA 3NKRA 1Y7AA 1Y6VA 4ZGAA 1AJCA 5K4PA 3Q3QA 5L0BA 4LR8A 1N2KA 1O98A 2W8SA 4GTYA 5DLTA 3NVLA 3TWZA 3TX0A 1B8JA 3UO0A 3TG0A 1EJJA 3SZZA 2W8DA 1E1ZP 3LXQA 1ZEBA 3IGZB 2IUCA 2GSUA 4MIVA 4LR9A 5DLVA 3WAXA 1ALHA 3T00A 3MK1A 3NKOA 4UPKA 2GSOA 1ELYA 2GSNA 1N2LA 3IDDA 5AJ9A 1KHKA 4NWXA 2W5WA 4CXUA 4KAYA 3T02A 4ZG7A 1AUKA 2W5QA 3NKPA 5L0EA 4QAXA 5HRTA 1ANJA 5KXAA 3M8ZA 4KM4A 1URAA 4UOPA 3NKQA 1ANIA 4UPLA 5DLWA 5EGHA 1EQJA 3SZYA 4GTZA 4YR1A 4MHXA 4LR2A 5IJSA 3DPCA 3BDGA 1ED9A 2QZUA 4CYSA 4CYRA 1EI6A 2W5TA 1HJKA 4CXSA 1E33P 1SHQA 1P49A 2W5RA 3NKMA 5L0KA 3M8WA 2D1GA 1EW9A 1ALJA 1ALKA 4CXKA 5GRRA 3A52A 5EGEA 5LRMA 1ELZA 4LREA 3UN5A 1HDHA 5IJQA 2XR9A 3MK2A 1URBA 4KAVA 4LRDA 3WAYA 1KH9A 4UOOA 4LRAA 1ALIA 3MK0A 5C66A 1ED8A 2IFYA 4MY4A 2GLQA 2W5SA 4UPIA 1EW2A 5GOVA 4LRBA 4N7TA 1KH4A 3ED4A 2ANHA 4UPHA 4LQYA 1ELXA
chains in the Genus database with same CATH superfamily
1O99A 1SHNA 2IUCB 3BDHA 3E2DA 1ZEFA 1E2SP 1KH5A 1KHLA 3CMRA 3IGYB 3M7VA 1AJBA 3M8YA 3B5QA 1KH7A 5LQQA 1KHJA 1ZEDA 5TJ3A 2XRGA 1AJAA 4LRCA 4LRFA 3UN3A 4GTWA 4ZG9A 3WAVA 1E3CP 4TN0A 1AJDA 1K7HA 2ZKTA 2VQRA 1EW8A 1KHNA 4KJDA 4KJGA 4UORA 5INHA 4FDIA 3BDFA 4FDJA 3WAWA 3KD8A 3NKNA 2GA3A 2G9YA 2RH6A 2W5XA 3DYCA 3UN2A 4ZG6A 1FSUA 4B56A 4GTXA 4LR7A 4NWJA 3UNYA 2W5VA 1HQAA 3BDGB 3OT9A 3T01A 3WBHA 5LRNA 2X98A 5LIAA 3NKRA 1Y7AA 1Y6VA 4ZGAA 1AJCA 5K4PA 3Q3QA 5L0BA 4LR8A 1N2KA 1O98A 2W8SA 4GTYA 5DLTA 3NVLA 3TWZA 3TX0A 1B8JA 3UO0A 3TG0A 1EJJA 3SZZA 2W8DA 1E1ZP 3LXQA 1ZEBA 3IGZB 2IUCA 2GSUA 4MIVA 4LR9A 5DLVA 3WAXA 1ALHA 3T00A 3MK1A 3NKOA 4UPKA 2GSOA 1ELYA 2GSNA 1N2LA 3IDDA 5AJ9A 1KHKA 4NWXA 2W5WA 4CXUA 4KAYA 3T02A 4ZG7A 1AUKA 2W5QA 3NKPA 5L0EA 4QAXA 5HRTA 1ANJA 5KXAA 3M8ZA 4KM4A 1URAA 4UOPA 3NKQA 1ANIA 4UPLA 5DLWA 5EGHA 1EQJA 3SZYA 4GTZA 4YR1A 4MHXA 4LR2A 5IJSA 3DPCA 3BDGA 1ED9A 2QZUA 4CYSA 4CYRA 1EI6A 2W5TA 1HJKA 4CXSA 1E33P 1SHQA 1P49A 2W5RA 3NKMA 5L0KA 3M8WA 2D1GA 1EW9A 1ALJA 1ALKA 4CXKA 5GRRA 3A52A 5EGEA 5LRMA 1ELZA 4LREA 3UN5A 1HDHA 5IJQA 2XR9A 3MK2A 1URBA 4KAVA 4LRDA 3WAYA 1KH9A 4UOOA 4LRAA 1ALIA 3MK0A 5C66A 1ED8A 2IFYA 4MY4A 2GLQA 2W5SA 4UPIA 1EW2A 5GOVA 4LRBA 4N7TA 1KH4A 3ED4A 2ANHA 4UPHA 4LQYA 1ELXA
chains in the Genus database with same CATH topology
1O99A 1SHNA 2IUCB 3BDHA 3E2DA 1ZEFA 1E2SP 1KH5A 1KHLA 3CMRA 3IGYB 3M7VA 1AJBA 3M8YA 3B5QA 1KH7A 5LQQA 1KHJA 1ZEDA 5TJ3A 2XRGA 1AJAA 4LRCA 4LRFA 3UN3A 4GTWA 4ZG9A 3WAVA 1E3CP 4TN0A 1AJDA 1K7HA 2ZKTA 2VQRA 1EW8A 1KHNA 4KJDA 4KJGA 4UORA 5INHA 4FDIA 3BDFA 4FDJA 3WAWA 3KD8A 3NKNA 2GA3A 2G9YA 2RH6A 2W5XA 3DYCA 3UN2A 4ZG6A 1FSUA 4B56A 4GTXA 4LR7A 4NWJA 3UNYA 2W5VA 1HQAA 3BDGB 3OT9A 3T01A 3WBHA 5LRNA 2X98A 5LIAA 3NKRA 1Y7AA 1Y6VA 4ZGAA 1AJCA 5K4PA 3Q3QA 5L0BA 4LR8A 1N2KA 1O98A 2W8SA 4GTYA 5DLTA 3NVLA 3TWZA 3TX0A 1B8JA 3UO0A 3TG0A 1EJJA 3SZZA 2W8DA 1E1ZP 3LXQA 1ZEBA 3IGZB 2IUCA 2GSUA 4MIVA 4LR9A 5DLVA 3WAXA 1ALHA 3T00A 3MK1A 3NKOA 4UPKA 2GSOA 1ELYA 2GSNA 1N2LA 3IDDA 5AJ9A 1KHKA 4NWXA 2W5WA 4CXUA 4KAYA 3T02A 4ZG7A 1AUKA 2W5QA 3NKPA 5L0EA 4QAXA 5HRTA 1ANJA 5KXAA 3M8ZA 4KM4A 1URAA 4UOPA 3NKQA 1ANIA 4UPLA 5DLWA 5EGHA 1EQJA 3SZYA 4GTZA 4YR1A 4MHXA 4LR2A 5IJSA 3DPCA 3BDGA 1ED9A 2QZUA 4CYSA 4CYRA 1EI6A 2W5TA 1HJKA 4CXSA 1E33P 1SHQA 1P49A 2W5RA 3NKMA 5L0KA 3M8WA 2D1GA 1EW9A 1ALJA 1ALKA 4CXKA 5GRRA 3A52A 5EGEA 5LRMA 1ELZA 4LREA 3UN5A 1HDHA 5IJQA 2XR9A 3MK2A 1URBA 4KAVA 4LRDA 3WAYA 1KH9A 4UOOA 4LRAA 1ALIA 3MK0A 5C66A 1ED8A 2IFYA 4MY4A 2GLQA 2W5SA 4UPIA 1EW2A 5GOVA 4LRBA 4N7TA 1KH4A 3ED4A 2ANHA 4UPHA 4LQYA 1ELXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O99 A;  1SHN A;  2IUC B;  3BDH A;  3E2D A;  1ZEF A;  1E2S P;  1KH5 A;  1KHL A;  3CMR A;  3IGY B;  3M7V A;  1AJB A;  3M8Y A;  3B5Q A;  1KH7 A;  5LQQ A;  1KHJ A;  1ZED A;  5TJ3 A;  2XRG A;  1AJA A;  4LRC A;  4LRF A;  3UN3 A;  4GTW A;  4ZG9 A;  3WAV A;  1E3C P;  4TN0 A;  1AJD A;  1K7H A;  2ZKT A;  2VQR A;  1EW8 A;  1KHN A;  4KJD A;  4KJG A;  4UOR A;  5INH A;  4FDI A;  3BDF A;  4FDJ A;  3WAW A;  3KD8 A;  3NKN A;  2GA3 A;  2G9Y A;  2RH6 A;  2W5X A;  3DYC A;  3UN2 A;  4ZG6 A;  1FSU A;  4B56 A;  4GTX A;  4LR7 A;  4NWJ A;  3UNY A;  2W5V A;  1HQA A;  3BDG B;  3OT9 A;  3T01 A;  3WBH A;  5LRN A;  2X98 A;  5LIA A;  3NKR A;  1Y7A A;  1Y6V A;  4ZGA A;  1AJC A;  5K4P A;  3Q3Q A;  5L0B A;  4LR8 A;  1N2K A;  1O98 A;  2W8S A;  4GTY A;  5DLT A;  3NVL A;  3TWZ A;  3TX0 A;  1B8J A;  3UO0 A;  3TG0 A;  1EJJ A;  3SZZ A;  2W8D A;  1E1Z P;  3LXQ A;  1ZEB A;  3IGZ B;  2IUC A;  2GSU A;  4MIV A;  4LR9 A;  5DLV A;  3WAX A;  1ALH A;  3T00 A;  3MK1 A;  3NKO A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  1N2L A;  3IDD A;  5AJ9 A;  1KHK A;  4NWX A;  2W5W A;  4CXU A;  4KAY A;  3T02 A;  4ZG7 A;  1AUK A;  2W5Q A;  3NKP A;  5L0E A;  4QAX A;  5HRT A;  1ANJ A;  5KXA A;  3M8Z A;  4KM4 A;  1URA A;  4UOP A;  3NKQ A;  1ANI A;  4UPL A;  5DLW A;  5EGH A;  1EQJ A;  3SZY A;  4GTZ A;  4YR1 A;  4MHX A;  4LR2 A;  5IJS A;  3DPC A;  3BDG A;  1ED9 A;  2QZU A;  4CYS A;  4CYR A;  1EI6 A;  2W5T A;  1HJK A;  4CXS A;  1E33 P;  1SHQ A;  1P49 A;  2W5R A;  3NKM A;  5L0K A;  3M8W A;  2D1G A;  1EW9 A;  1ALJ A;  1ALK A;  4CXK A;  5GRR A;  3A52 A;  5EGE A;  5LRM A;  1ELZ A;  4LRE A;  3UN5 A;  1HDH A;  5IJQ A;  2XR9 A;  3MK2 A;  1URB A;  4KAV A;  4LRD A;  3WAY A;  1KH9 A;  4UOO A;  4LRA A;  1ALI A;  3MK0 A;  5C66 A;  1ED8 A;  2IFY A;  4MY4 A;  2GLQ A;  2W5S A;  4UPI A;  1EW2 A;  5GOV A;  4LRB A;  4N7T A;  1KH4 A;  3ED4 A;  2ANH A;  4UPH A;  4LQY A;  1ELX A; 
#chains in the Genus database with same CATH topology
 1O99 A;  1SHN A;  2IUC B;  3BDH A;  3E2D A;  1ZEF A;  1E2S P;  1KH5 A;  1KHL A;  3CMR A;  3IGY B;  3M7V A;  1AJB A;  3M8Y A;  3B5Q A;  1KH7 A;  5LQQ A;  1KHJ A;  1ZED A;  5TJ3 A;  2XRG A;  1AJA A;  4LRC A;  4LRF A;  3UN3 A;  4GTW A;  4ZG9 A;  3WAV A;  1E3C P;  4TN0 A;  1AJD A;  1K7H A;  2ZKT A;  2VQR A;  1EW8 A;  1KHN A;  4KJD A;  4KJG A;  4UOR A;  5INH A;  4FDI A;  3BDF A;  4FDJ A;  3WAW A;  3KD8 A;  3NKN A;  2GA3 A;  2G9Y A;  2RH6 A;  2W5X A;  3DYC A;  3UN2 A;  4ZG6 A;  1FSU A;  4B56 A;  4GTX A;  4LR7 A;  4NWJ A;  3UNY A;  2W5V A;  1HQA A;  3BDG B;  3OT9 A;  3T01 A;  3WBH A;  5LRN A;  2X98 A;  5LIA A;  3NKR A;  1Y7A A;  1Y6V A;  4ZGA A;  1AJC A;  5K4P A;  3Q3Q A;  5L0B A;  4LR8 A;  1N2K A;  1O98 A;  2W8S A;  4GTY A;  5DLT A;  3NVL A;  3TWZ A;  3TX0 A;  1B8J A;  3UO0 A;  3TG0 A;  1EJJ A;  3SZZ A;  2W8D A;  1E1Z P;  3LXQ A;  1ZEB A;  3IGZ B;  2IUC A;  2GSU A;  4MIV A;  4LR9 A;  5DLV A;  3WAX A;  1ALH A;  3T00 A;  3MK1 A;  3NKO A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  1N2L A;  3IDD A;  5AJ9 A;  1KHK A;  4NWX A;  2W5W A;  4CXU A;  4KAY A;  3T02 A;  4ZG7 A;  1AUK A;  2W5Q A;  3NKP A;  5L0E A;  4QAX A;  5HRT A;  1ANJ A;  5KXA A;  3M8Z A;  4KM4 A;  1URA A;  4UOP A;  3NKQ A;  1ANI A;  4UPL A;  5DLW A;  5EGH A;  1EQJ A;  3SZY A;  4GTZ A;  4YR1 A;  4MHX A;  4LR2 A;  5IJS A;  3DPC A;  3BDG A;  1ED9 A;  2QZU A;  4CYS A;  4CYR A;  1EI6 A;  2W5T A;  1HJK A;  4CXS A;  1E33 P;  1SHQ A;  1P49 A;  2W5R A;  3NKM A;  5L0K A;  3M8W A;  2D1G A;  1EW9 A;  1ALJ A;  1ALK A;  4CXK A;  5GRR A;  3A52 A;  5EGE A;  5LRM A;  1ELZ A;  4LRE A;  3UN5 A;  1HDH A;  5IJQ A;  2XR9 A;  3MK2 A;  1URB A;  4KAV A;  4LRD A;  3WAY A;  1KH9 A;  4UOO A;  4LRA A;  1ALI A;  3MK0 A;  5C66 A;  1ED8 A;  2IFY A;  4MY4 A;  2GLQ A;  2W5S A;  4UPI A;  1EW2 A;  5GOV A;  4LRB A;  4N7T A;  1KH4 A;  3ED4 A;  2ANH A;  4UPH A;  4LQY A;  1ELX A; 
#chains in the Genus database with same CATH homology
 1O99 A;  1SHN A;  2IUC B;  3BDH A;  3E2D A;  1ZEF A;  1E2S P;  1KH5 A;  1KHL A;  3CMR A;  3IGY B;  3M7V A;  1AJB A;  3M8Y A;  3B5Q A;  1KH7 A;  5LQQ A;  1KHJ A;  1ZED A;  5TJ3 A;  2XRG A;  1AJA A;  4LRC A;  4LRF A;  3UN3 A;  4GTW A;  4ZG9 A;  3WAV A;  1E3C P;  4TN0 A;  1AJD A;  1K7H A;  2ZKT A;  2VQR A;  1EW8 A;  1KHN A;  4KJD A;  4KJG A;  4UOR A;  5INH A;  4FDI A;  3BDF A;  4FDJ A;  3WAW A;  3KD8 A;  3NKN A;  2GA3 A;  2G9Y A;  2RH6 A;  2W5X A;  3DYC A;  3UN2 A;  4ZG6 A;  1FSU A;  4B56 A;  4GTX A;  4LR7 A;  4NWJ A;  3UNY A;  2W5V A;  1HQA A;  3BDG B;  3OT9 A;  3T01 A;  3WBH A;  5LRN A;  2X98 A;  5LIA A;  3NKR A;  1Y7A A;  1Y6V A;  4ZGA A;  1AJC A;  5K4P A;  3Q3Q A;  5L0B A;  4LR8 A;  1N2K A;  1O98 A;  2W8S A;  4GTY A;  5DLT A;  3NVL A;  3TWZ A;  3TX0 A;  1B8J A;  3UO0 A;  3TG0 A;  1EJJ A;  3SZZ A;  2W8D A;  1E1Z P;  3LXQ A;  1ZEB A;  3IGZ B;  2IUC A;  2GSU A;  4MIV A;  4LR9 A;  5DLV A;  3WAX A;  1ALH A;  3T00 A;  3MK1 A;  3NKO A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  1N2L A;  3IDD A;  5AJ9 A;  1KHK A;  4NWX A;  2W5W A;  4CXU A;  4KAY A;  3T02 A;  4ZG7 A;  1AUK A;  2W5Q A;  3NKP A;  5L0E A;  4QAX A;  5HRT A;  1ANJ A;  5KXA A;  3M8Z A;  4KM4 A;  1URA A;  4UOP A;  3NKQ A;  1ANI A;  4UPL A;  5DLW A;  5EGH A;  1EQJ A;  3SZY A;  4GTZ A;  4YR1 A;  4MHX A;  4LR2 A;  5IJS A;  3DPC A;  3BDG A;  1ED9 A;  2QZU A;  4CYS A;  4CYR A;  1EI6 A;  2W5T A;  1HJK A;  4CXS A;  1E33 P;  1SHQ A;  1P49 A;  2W5R A;  3NKM A;  5L0K A;  3M8W A;  2D1G A;  1EW9 A;  1ALJ A;  1ALK A;  4CXK A;  5GRR A;  3A52 A;  5EGE A;  5LRM A;  1ELZ A;  4LRE A;  3UN5 A;  1HDH A;  5IJQ A;  2XR9 A;  3MK2 A;  1URB A;  4KAV A;  4LRD A;  3WAY A;  1KH9 A;  4UOO A;  4LRA A;  1ALI A;  3MK0 A;  5C66 A;  1ED8 A;  2IFY A;  4MY4 A;  2GLQ A;  2W5S A;  4UPI A;  1EW2 A;  5GOV A;  4LRB A;  4N7T A;  1KH4 A;  3ED4 A;  2ANH A;  4UPH A;  4LQY A;  1ELX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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