3MK0A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 178
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk0A00
3MK1A 3NKMA 1EW2A 2W5WA 1E3CP 1KHLA 4LRBA 3M8ZA 2W5RA 4LR9A 3WAVA 2W5TA 2GLQA 3T02A 3IDDA 4GTWA 1ALIA 4LR7A 3OT9A 3E2DA 4KM4A 5EGHA 3DPCA 1ED9A 3IGYB 4KAYA 5C66A 5LRNA 4UORA 1ALKA 2IUCA 2G9YA 5HRTA 4CYRA 1EW9A 1KHNA 3NKPA 4UOPA 4FDJA 4UPKA 4CYSA 1B8JA 2GSNA 5EGEA 5IJQA 1O98A 2W5XA 4UPHA 3UN5A 4MHXA 4ZG9A 2VQRA 3NKOA 4LQYA 3A52A 1KH4A 3WBHA 3LXQA 4MIVA 3BDGB 1ANJA 2W5SA 5K4PA 3B5QA 3Q3QA 4GTYA 1E33P 5L0EA 4LR2A 1AJDA 3CMRA 3NKRA 4LR8A 1ALHA 1URAA 2GSOA 1P49A 1SHNA 4KJGA 4TN0A 1AUKA 4KAVA 3ED4A 3IGZB 5GOVA 5TJ3A 1KH7A 5KXAA 3NKNA 1KHJA 2XR9A 1AJBA 3WAYA 5LRMA 3TWZA 3UNYA 1ELXA 4ZG6A 4ZG7A 1KHKA 4MY4A 3BDHA 3DYCA 1Y6VA 2IUCB 3M8YA 3TG0A 1N2LA 4UPLA 2GA3A 4QAXA 2D1GA 3KD8A 2W5VA 4UPIA 4YR1A 3BDFA 1KH5A 5DLVA 4N7TA 4LRDA 3NKQA 5DLTA 4ZGAA 1HQAA 3WAXA 3UN3A 4LRCA 1EJJA 1AJAA 1URBA 4FDIA 3UN2A 1ALJA 4LRAA 1K7HA 3UO0A 3SZYA 3T00A 4LRFA 2RH6A 1ANIA 1FSUA 3WAWA 5L0KA 4CXUA 2W8SA 2X98A 3NVLA 4GTXA 3T01A 5INHA 1EW8A 4NWXA 5AJ9A 4UOOA 5GRRA 5DLWA 5IJSA 2ZKTA 3M7VA 1ZEDA 3SZZA 1HJKA 1KH9A 1EI6A 4CXKA 1Y7AA 5LIAA 1ED8A 1SHQA 1E1ZP 1ELYA 4NWJA 4B56A 2W8DA 3MK2A 1HDHA 1N2KA 2GSUA 1AJCA 3TX0A 2W5QA 2IFYA 4LREA 4GTZA 1ELZA 3BDGA 1EQJA 2ANHA 2XRGA 1E2SP 1ZEFA 3M8WA 3MK0A 5LQQA 2QZUA 4CXSA 5L0BA 4KJDA 1O99A 1ZEBA
chains in the Genus database with same CATH superfamily
3MK1A 3NKMA 1EW2A 2W5WA 1E3CP 1KHLA 4LRBA 3M8ZA 2W5RA 4LR9A 3WAVA 2W5TA 2GLQA 3T02A 3IDDA 4GTWA 1ALIA 4LR7A 3OT9A 3E2DA 4KM4A 5EGHA 3DPCA 1ED9A 3IGYB 4KAYA 5C66A 5LRNA 4UORA 1ALKA 2IUCA 2G9YA 5HRTA 4CYRA 1EW9A 1KHNA 3NKPA 4UOPA 4FDJA 4UPKA 4CYSA 1B8JA 2GSNA 5EGEA 5IJQA 1O98A 2W5XA 4UPHA 3UN5A 4MHXA 4ZG9A 2VQRA 3NKOA 4LQYA 3A52A 1KH4A 3WBHA 3LXQA 4MIVA 3BDGB 1ANJA 2W5SA 5K4PA 3B5QA 3Q3QA 4GTYA 1E33P 5L0EA 4LR2A 1AJDA 3CMRA 3NKRA 4LR8A 1ALHA 1URAA 2GSOA 1P49A 1SHNA 4KJGA 4TN0A 1AUKA 4KAVA 3ED4A 3IGZB 5GOVA 5TJ3A 1KH7A 5KXAA 3NKNA 1KHJA 2XR9A 1AJBA 3WAYA 5LRMA 3TWZA 3UNYA 1ELXA 4ZG6A 4ZG7A 1KHKA 4MY4A 3BDHA 3DYCA 1Y6VA 2IUCB 3M8YA 3TG0A 1N2LA 4UPLA 2GA3A 4QAXA 2D1GA 3KD8A 2W5VA 4UPIA 4YR1A 3BDFA 1KH5A 5DLVA 4N7TA 4LRDA 3NKQA 5DLTA 4ZGAA 1HQAA 3WAXA 3UN3A 4LRCA 1EJJA 1AJAA 1URBA 4FDIA 3UN2A 1ALJA 4LRAA 1K7HA 3UO0A 3SZYA 3T00A 4LRFA 2RH6A 1ANIA 1FSUA 3WAWA 5L0KA 4CXUA 2W8SA 2X98A 3NVLA 4GTXA 3T01A 5INHA 1EW8A 4NWXA 5AJ9A 4UOOA 5GRRA 5DLWA 5IJSA 2ZKTA 3M7VA 1ZEDA 3SZZA 1HJKA 1KH9A 1EI6A 4CXKA 1Y7AA 5LIAA 1ED8A 1SHQA 1E1ZP 1ELYA 4NWJA 4B56A 2W8DA 3MK2A 1HDHA 1N2KA 2GSUA 1AJCA 3TX0A 2W5QA 2IFYA 4LREA 4GTZA 1ELZA 3BDGA 1EQJA 2ANHA 2XRGA 1E2SP 1ZEFA 3M8WA 3MK0A 5LQQA 2QZUA 4CXSA 5L0BA 4KJDA 1O99A 1ZEBA
chains in the Genus database with same CATH topology
3MK1A 3NKMA 1EW2A 2W5WA 1E3CP 1KHLA 4LRBA 3M8ZA 2W5RA 4LR9A 3WAVA 2W5TA 2GLQA 3T02A 3IDDA 4GTWA 1ALIA 4LR7A 3OT9A 3E2DA 4KM4A 5EGHA 3DPCA 1ED9A 3IGYB 4KAYA 5C66A 5LRNA 4UORA 1ALKA 2IUCA 2G9YA 5HRTA 4CYRA 1EW9A 1KHNA 3NKPA 4UOPA 4FDJA 4UPKA 4CYSA 1B8JA 2GSNA 5EGEA 5IJQA 1O98A 2W5XA 4UPHA 3UN5A 4MHXA 4ZG9A 2VQRA 3NKOA 4LQYA 3A52A 1KH4A 3WBHA 3LXQA 4MIVA 3BDGB 1ANJA 2W5SA 5K4PA 3B5QA 3Q3QA 4GTYA 1E33P 5L0EA 4LR2A 1AJDA 3CMRA 3NKRA 4LR8A 1ALHA 1URAA 2GSOA 1P49A 1SHNA 4KJGA 4TN0A 1AUKA 4KAVA 3ED4A 3IGZB 5GOVA 5TJ3A 1KH7A 5KXAA 3NKNA 1KHJA 2XR9A 1AJBA 3WAYA 5LRMA 3TWZA 3UNYA 1ELXA 4ZG6A 4ZG7A 1KHKA 4MY4A 3BDHA 3DYCA 1Y6VA 2IUCB 3M8YA 3TG0A 1N2LA 4UPLA 2GA3A 4QAXA 2D1GA 3KD8A 2W5VA 4UPIA 4YR1A 3BDFA 1KH5A 5DLVA 4N7TA 4LRDA 3NKQA 5DLTA 4ZGAA 1HQAA 3WAXA 3UN3A 4LRCA 1EJJA 1AJAA 1URBA 4FDIA 3UN2A 1ALJA 4LRAA 1K7HA 3UO0A 3SZYA 3T00A 4LRFA 2RH6A 1ANIA 1FSUA 3WAWA 5L0KA 4CXUA 2W8SA 2X98A 3NVLA 4GTXA 3T01A 5INHA 1EW8A 4NWXA 5AJ9A 4UOOA 5GRRA 5DLWA 5IJSA 2ZKTA 3M7VA 1ZEDA 3SZZA 1HJKA 1KH9A 1EI6A 4CXKA 1Y7AA 5LIAA 1ED8A 1SHQA 1E1ZP 1ELYA 4NWJA 4B56A 2W8DA 3MK2A 1HDHA 1N2KA 2GSUA 1AJCA 3TX0A 2W5QA 2IFYA 4LREA 4GTZA 1ELZA 3BDGA 1EQJA 2ANHA 2XRGA 1E2SP 1ZEFA 3M8WA 3MK0A 5LQQA 2QZUA 4CXSA 5L0BA 4KJDA 1O99A 1ZEBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK1 A;  3NKM A;  1EW2 A;  2W5W A;  1E3C P;  1KHL A;  4LRB A;  3M8Z A;  2W5R A;  4LR9 A;  3WAV A;  2W5T A;  2GLQ A;  3T02 A;  3IDD A;  4GTW A;  1ALI A;  4LR7 A;  3OT9 A;  3E2D A;  4KM4 A;  5EGH A;  3DPC A;  1ED9 A;  3IGY B;  4KAY A;  5C66 A;  5LRN A;  4UOR A;  1ALK A;  2IUC A;  2G9Y A;  5HRT A;  4CYR A;  1EW9 A;  1KHN A;  3NKP A;  4UOP A;  4FDJ A;  4UPK A;  4CYS A;  1B8J A;  2GSN A;  5EGE A;  5IJQ A;  1O98 A;  2W5X A;  4UPH A;  3UN5 A;  4MHX A;  4ZG9 A;  2VQR A;  3NKO A;  4LQY A;  3A52 A;  1KH4 A;  3WBH A;  3LXQ A;  4MIV A;  3BDG B;  1ANJ A;  2W5S A;  5K4P A;  3B5Q A;  3Q3Q A;  4GTY A;  1E33 P;  5L0E A;  4LR2 A;  1AJD A;  3CMR A;  3NKR A;  4LR8 A;  1ALH A;  1URA A;  2GSO A;  1P49 A;  1SHN A;  4KJG A;  4TN0 A;  1AUK A;  4KAV A;  3ED4 A;  3IGZ B;  5GOV A;  5TJ3 A;  1KH7 A;  5KXA A;  3NKN A;  1KHJ A;  2XR9 A;  1AJB A;  3WAY A;  5LRM A;  3TWZ A;  3UNY A;  1ELX A;  4ZG6 A;  4ZG7 A;  1KHK A;  4MY4 A;  3BDH A;  3DYC A;  1Y6V A;  2IUC B;  3M8Y A;  3TG0 A;  1N2L A;  4UPL A;  2GA3 A;  4QAX A;  2D1G A;  3KD8 A;  2W5V A;  4UPI A;  4YR1 A;  3BDF A;  1KH5 A;  5DLV A;  4N7T A;  4LRD A;  3NKQ A;  5DLT A;  4ZGA A;  1HQA A;  3WAX A;  3UN3 A;  4LRC A;  1EJJ A;  1AJA A;  1URB A;  4FDI A;  3UN2 A;  1ALJ A;  4LRA A;  1K7H A;  3UO0 A;  3SZY A;  3T00 A;  4LRF A;  2RH6 A;  1ANI A;  1FSU A;  3WAW A;  5L0K A;  4CXU A;  2W8S A;  2X98 A;  3NVL A;  4GTX A;  3T01 A;  5INH A;  1EW8 A;  4NWX A;  5AJ9 A;  4UOO A;  5GRR A;  5DLW A;  5IJS A;  2ZKT A;  3M7V A;  1ZED A;  3SZZ A;  1HJK A;  1KH9 A;  1EI6 A;  4CXK A;  1Y7A A;  5LIA A;  1ED8 A;  1SHQ A;  1E1Z P;  1ELY A;  4NWJ A;  4B56 A;  2W8D A;  3MK2 A;  1HDH A;  1N2K A;  2GSU A;  1AJC A;  3TX0 A;  2W5Q A;  2IFY A;  4LRE A;  4GTZ A;  1ELZ A;  3BDG A;  1EQJ A;  2ANH A;  2XRG A;  1E2S P;  1ZEF A;  3M8W A;  3MK0 A;  5LQQ A;  2QZU A;  4CXS A;  5L0B A;  4KJD A;  1O99 A;  1ZEB A; 
#chains in the Genus database with same CATH topology
 3MK1 A;  3NKM A;  1EW2 A;  2W5W A;  1E3C P;  1KHL A;  4LRB A;  3M8Z A;  2W5R A;  4LR9 A;  3WAV A;  2W5T A;  2GLQ A;  3T02 A;  3IDD A;  4GTW A;  1ALI A;  4LR7 A;  3OT9 A;  3E2D A;  4KM4 A;  5EGH A;  3DPC A;  1ED9 A;  3IGY B;  4KAY A;  5C66 A;  5LRN A;  4UOR A;  1ALK A;  2IUC A;  2G9Y A;  5HRT A;  4CYR A;  1EW9 A;  1KHN A;  3NKP A;  4UOP A;  4FDJ A;  4UPK A;  4CYS A;  1B8J A;  2GSN A;  5EGE A;  5IJQ A;  1O98 A;  2W5X A;  4UPH A;  3UN5 A;  4MHX A;  4ZG9 A;  2VQR A;  3NKO A;  4LQY A;  3A52 A;  1KH4 A;  3WBH A;  3LXQ A;  4MIV A;  3BDG B;  1ANJ A;  2W5S A;  5K4P A;  3B5Q A;  3Q3Q A;  4GTY A;  1E33 P;  5L0E A;  4LR2 A;  1AJD A;  3CMR A;  3NKR A;  4LR8 A;  1ALH A;  1URA A;  2GSO A;  1P49 A;  1SHN A;  4KJG A;  4TN0 A;  1AUK A;  4KAV A;  3ED4 A;  3IGZ B;  5GOV A;  5TJ3 A;  1KH7 A;  5KXA A;  3NKN A;  1KHJ A;  2XR9 A;  1AJB A;  3WAY A;  5LRM A;  3TWZ A;  3UNY A;  1ELX A;  4ZG6 A;  4ZG7 A;  1KHK A;  4MY4 A;  3BDH A;  3DYC A;  1Y6V A;  2IUC B;  3M8Y A;  3TG0 A;  1N2L A;  4UPL A;  2GA3 A;  4QAX A;  2D1G A;  3KD8 A;  2W5V A;  4UPI A;  4YR1 A;  3BDF A;  1KH5 A;  5DLV A;  4N7T A;  4LRD A;  3NKQ A;  5DLT A;  4ZGA A;  1HQA A;  3WAX A;  3UN3 A;  4LRC A;  1EJJ A;  1AJA A;  1URB A;  4FDI A;  3UN2 A;  1ALJ A;  4LRA A;  1K7H A;  3UO0 A;  3SZY A;  3T00 A;  4LRF A;  2RH6 A;  1ANI A;  1FSU A;  3WAW A;  5L0K A;  4CXU A;  2W8S A;  2X98 A;  3NVL A;  4GTX A;  3T01 A;  5INH A;  1EW8 A;  4NWX A;  5AJ9 A;  4UOO A;  5GRR A;  5DLW A;  5IJS A;  2ZKT A;  3M7V A;  1ZED A;  3SZZ A;  1HJK A;  1KH9 A;  1EI6 A;  4CXK A;  1Y7A A;  5LIA A;  1ED8 A;  1SHQ A;  1E1Z P;  1ELY A;  4NWJ A;  4B56 A;  2W8D A;  3MK2 A;  1HDH A;  1N2K A;  2GSU A;  1AJC A;  3TX0 A;  2W5Q A;  2IFY A;  4LRE A;  4GTZ A;  1ELZ A;  3BDG A;  1EQJ A;  2ANH A;  2XRG A;  1E2S P;  1ZEF A;  3M8W A;  3MK0 A;  5LQQ A;  2QZU A;  4CXS A;  5L0B A;  4KJD A;  1O99 A;  1ZEB A; 
#chains in the Genus database with same CATH homology
 3MK1 A;  3NKM A;  1EW2 A;  2W5W A;  1E3C P;  1KHL A;  4LRB A;  3M8Z A;  2W5R A;  4LR9 A;  3WAV A;  2W5T A;  2GLQ A;  3T02 A;  3IDD A;  4GTW A;  1ALI A;  4LR7 A;  3OT9 A;  3E2D A;  4KM4 A;  5EGH A;  3DPC A;  1ED9 A;  3IGY B;  4KAY A;  5C66 A;  5LRN A;  4UOR A;  1ALK A;  2IUC A;  2G9Y A;  5HRT A;  4CYR A;  1EW9 A;  1KHN A;  3NKP A;  4UOP A;  4FDJ A;  4UPK A;  4CYS A;  1B8J A;  2GSN A;  5EGE A;  5IJQ A;  1O98 A;  2W5X A;  4UPH A;  3UN5 A;  4MHX A;  4ZG9 A;  2VQR A;  3NKO A;  4LQY A;  3A52 A;  1KH4 A;  3WBH A;  3LXQ A;  4MIV A;  3BDG B;  1ANJ A;  2W5S A;  5K4P A;  3B5Q A;  3Q3Q A;  4GTY A;  1E33 P;  5L0E A;  4LR2 A;  1AJD A;  3CMR A;  3NKR A;  4LR8 A;  1ALH A;  1URA A;  2GSO A;  1P49 A;  1SHN A;  4KJG A;  4TN0 A;  1AUK A;  4KAV A;  3ED4 A;  3IGZ B;  5GOV A;  5TJ3 A;  1KH7 A;  5KXA A;  3NKN A;  1KHJ A;  2XR9 A;  1AJB A;  3WAY A;  5LRM A;  3TWZ A;  3UNY A;  1ELX A;  4ZG6 A;  4ZG7 A;  1KHK A;  4MY4 A;  3BDH A;  3DYC A;  1Y6V A;  2IUC B;  3M8Y A;  3TG0 A;  1N2L A;  4UPL A;  2GA3 A;  4QAX A;  2D1G A;  3KD8 A;  2W5V A;  4UPI A;  4YR1 A;  3BDF A;  1KH5 A;  5DLV A;  4N7T A;  4LRD A;  3NKQ A;  5DLT A;  4ZGA A;  1HQA A;  3WAX A;  3UN3 A;  4LRC A;  1EJJ A;  1AJA A;  1URB A;  4FDI A;  3UN2 A;  1ALJ A;  4LRA A;  1K7H A;  3UO0 A;  3SZY A;  3T00 A;  4LRF A;  2RH6 A;  1ANI A;  1FSU A;  3WAW A;  5L0K A;  4CXU A;  2W8S A;  2X98 A;  3NVL A;  4GTX A;  3T01 A;  5INH A;  1EW8 A;  4NWX A;  5AJ9 A;  4UOO A;  5GRR A;  5DLW A;  5IJS A;  2ZKT A;  3M7V A;  1ZED A;  3SZZ A;  1HJK A;  1KH9 A;  1EI6 A;  4CXK A;  1Y7A A;  5LIA A;  1ED8 A;  1SHQ A;  1E1Z P;  1ELY A;  4NWJ A;  4B56 A;  2W8D A;  3MK2 A;  1HDH A;  1N2K A;  2GSU A;  1AJC A;  3TX0 A;  2W5Q A;  2IFY A;  4LRE A;  4GTZ A;  1ELZ A;  3BDG A;  1EQJ A;  2ANH A;  2XRG A;  1E2S P;  1ZEF A;  3M8W A;  3MK0 A;  5LQQ A;  2QZU A;  4CXS A;  5L0B A;  4KJD A;  1O99 A;  1ZEB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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