3MK0A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 178
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
Knots found
sequence length
481
structure length
480
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase, placental type
total genus 178
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk0A00
5L0KA 3DYCA 4KM4A 3NKRA 4FDIA 1KHNA 4CXUA 1KHJA 2W5TA 1ANIA 2ZKTA 1N2LA 4B56A 3B5QA 5LRNA 2QZUA 3OT9A 1Y6VA 3UNYA 1EQJA 4GTXA 3T00A 2D1GA 5KXAA 1KH4A 3NKOA 5TJ3A 2GSUA 5GOVA 4UOPA 1HQAA 3Q3QA 5C66A 4ZGAA 1E3CP 1EW9A 3IDDA 4ZG6A 3SZZA 3WAXA 3BDGA 4UPIA 3MK1A 3BDGB 3CMRA 3IGYB 3NKNA 4LR9A 1EW8A 1HJKA 1P49A 3NKMA 1AJBA 1AJAA 2GSNA 2W5SA 3E2DA 3NVLA 4N7TA 4QAXA 4TN0A 5HRTA 2X98A 4YR1A 3M8WA 5AJ9A 1ALHA 2VQRA 1HDHA 3KD8A 4UORA 5EGHA 4KAVA 3TWZA 5GRRA 1ANJA 2W8DA 1O98A 1URBA 1EW2A 3A52A 3BDFA 4NWXA 5L0BA 2W5XA 1N2KA 4CXSA 1FSUA 5LRMA 1E33P 3TG0A 3SZYA 5LIAA 3BDHA 2RH6A 4ZG7A 3M7VA 3MK2A 2GLQA 4GTYA 2IUCB 2IFYA 4UPKA 5EGEA 2GSOA 2W5WA 2W8SA 1ELYA 3UN5A 3WBHA 1AJCA 4KJGA 3M8ZA 3T02A 1K7HA 3WAYA 4NWJA 1E2SP 1ELXA 3UN2A 5L0EA 4GTZA 1KH7A 4LRCA 4LRDA 3UO0A 3UN3A 4MY4A 1EI6A 3TX0A 1ED9A 1ALIA 4UPLA 4GTWA 1AJDA 4CYSA 2IUCA 4ZG9A 1ELZA 2XRGA 4KAYA 4LREA 5LQQA 5IJSA 1KHKA 4MHXA 1E1ZP 3NKPA 4CYRA 1URAA 4LR8A 1O99A 1Y7AA 5K4PA 1EJJA 1SHNA 1KH9A 4LQYA 4UOOA 3DPCA 4KJDA 1ZEDA 3LXQA 3T01A 3MK0A 5DLTA 5INHA 5DLWA 3IGZB 4CXKA 1ZEBA 4LR2A 2W5RA 1ZEFA 2XR9A 1ED8A 2GA3A 4LRFA 1B8JA 1SHQA 2G9YA 3ED4A 4UPHA 4MIVA 1ALKA 4LRAA 2W5QA 3WAWA 5IJQA 1ALJA 3M8YA 4FDJA 3WAVA 3NKQA 4LR7A 1AUKA 1KH5A 2ANHA 4LRBA 2W5VA 5DLVA 1KHLA
chains in the Genus database with same CATH superfamily
5L0KA 3DYCA 4KM4A 3NKRA 4FDIA 1KHNA 4CXUA 1KHJA 2W5TA 1ANIA 2ZKTA 1N2LA 4B56A 3B5QA 5LRNA 2QZUA 3OT9A 1Y6VA 3UNYA 1EQJA 4GTXA 3T00A 2D1GA 5KXAA 1KH4A 3NKOA 5TJ3A 2GSUA 5GOVA 4UOPA 1HQAA 3Q3QA 5C66A 4ZGAA 1E3CP 1EW9A 3IDDA 4ZG6A 3SZZA 3WAXA 3BDGA 4UPIA 3MK1A 3BDGB 3CMRA 3IGYB 3NKNA 4LR9A 1EW8A 1HJKA 1P49A 3NKMA 1AJBA 1AJAA 2GSNA 2W5SA 3E2DA 3NVLA 4N7TA 4QAXA 4TN0A 5HRTA 2X98A 4YR1A 3M8WA 5AJ9A 1ALHA 2VQRA 1HDHA 3KD8A 4UORA 5EGHA 4KAVA 3TWZA 5GRRA 1ANJA 2W8DA 1O98A 1URBA 1EW2A 3A52A 3BDFA 4NWXA 5L0BA 2W5XA 1N2KA 4CXSA 1FSUA 5LRMA 1E33P 3TG0A 3SZYA 5LIAA 3BDHA 2RH6A 4ZG7A 3M7VA 3MK2A 2GLQA 4GTYA 2IUCB 2IFYA 4UPKA 5EGEA 2GSOA 2W5WA 2W8SA 1ELYA 3UN5A 3WBHA 1AJCA 4KJGA 3M8ZA 3T02A 1K7HA 3WAYA 4NWJA 1E2SP 1ELXA 3UN2A 5L0EA 4GTZA 1KH7A 4LRCA 4LRDA 3UO0A 3UN3A 4MY4A 1EI6A 3TX0A 1ED9A 1ALIA 4UPLA 4GTWA 1AJDA 4CYSA 2IUCA 4ZG9A 1ELZA 2XRGA 4KAYA 4LREA 5LQQA 5IJSA 1KHKA 4MHXA 1E1ZP 3NKPA 4CYRA 1URAA 4LR8A 1O99A 1Y7AA 5K4PA 1EJJA 1SHNA 1KH9A 4LQYA 4UOOA 3DPCA 4KJDA 1ZEDA 3LXQA 3T01A 3MK0A 5DLTA 5INHA 5DLWA 3IGZB 4CXKA 1ZEBA 4LR2A 2W5RA 1ZEFA 2XR9A 1ED8A 2GA3A 4LRFA 1B8JA 1SHQA 2G9YA 3ED4A 4UPHA 4MIVA 1ALKA 4LRAA 2W5QA 3WAWA 5IJQA 1ALJA 3M8YA 4FDJA 3WAVA 3NKQA 4LR7A 1AUKA 1KH5A 2ANHA 4LRBA 2W5VA 5DLVA 1KHLA
chains in the Genus database with same CATH topology
5L0KA 3DYCA 4KM4A 3NKRA 4FDIA 1KHNA 4CXUA 1KHJA 2W5TA 1ANIA 2ZKTA 1N2LA 4B56A 3B5QA 5LRNA 2QZUA 3OT9A 1Y6VA 3UNYA 1EQJA 4GTXA 3T00A 2D1GA 5KXAA 1KH4A 3NKOA 5TJ3A 2GSUA 5GOVA 4UOPA 1HQAA 3Q3QA 5C66A 4ZGAA 1E3CP 1EW9A 3IDDA 4ZG6A 3SZZA 3WAXA 3BDGA 4UPIA 3MK1A 3BDGB 3CMRA 3IGYB 3NKNA 4LR9A 1EW8A 1HJKA 1P49A 3NKMA 1AJBA 1AJAA 2GSNA 2W5SA 3E2DA 3NVLA 4N7TA 4QAXA 4TN0A 5HRTA 2X98A 4YR1A 3M8WA 5AJ9A 1ALHA 2VQRA 1HDHA 3KD8A 4UORA 5EGHA 4KAVA 3TWZA 5GRRA 1ANJA 2W8DA 1O98A 1URBA 1EW2A 3A52A 3BDFA 4NWXA 5L0BA 2W5XA 1N2KA 4CXSA 1FSUA 5LRMA 1E33P 3TG0A 3SZYA 5LIAA 3BDHA 2RH6A 4ZG7A 3M7VA 3MK2A 2GLQA 4GTYA 2IUCB 2IFYA 4UPKA 5EGEA 2GSOA 2W5WA 2W8SA 1ELYA 3UN5A 3WBHA 1AJCA 4KJGA 3M8ZA 3T02A 1K7HA 3WAYA 4NWJA 1E2SP 1ELXA 3UN2A 5L0EA 4GTZA 1KH7A 4LRCA 4LRDA 3UO0A 3UN3A 4MY4A 1EI6A 3TX0A 1ED9A 1ALIA 4UPLA 4GTWA 1AJDA 4CYSA 2IUCA 4ZG9A 1ELZA 2XRGA 4KAYA 4LREA 5LQQA 5IJSA 1KHKA 4MHXA 1E1ZP 3NKPA 4CYRA 1URAA 4LR8A 1O99A 1Y7AA 5K4PA 1EJJA 1SHNA 1KH9A 4LQYA 4UOOA 3DPCA 4KJDA 1ZEDA 3LXQA 3T01A 3MK0A 5DLTA 5INHA 5DLWA 3IGZB 4CXKA 1ZEBA 4LR2A 2W5RA 1ZEFA 2XR9A 1ED8A 2GA3A 4LRFA 1B8JA 1SHQA 2G9YA 3ED4A 4UPHA 4MIVA 1ALKA 4LRAA 2W5QA 3WAWA 5IJQA 1ALJA 3M8YA 4FDJA 3WAVA 3NKQA 4LR7A 1AUKA 1KH5A 2ANHA 4LRBA 2W5VA 5DLVA 1KHLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5L0K A;  3DYC A;  4KM4 A;  3NKR A;  4FDI A;  1KHN A;  4CXU A;  1KHJ A;  2W5T A;  1ANI A;  2ZKT A;  1N2L A;  4B56 A;  3B5Q A;  5LRN A;  2QZU A;  3OT9 A;  1Y6V A;  3UNY A;  1EQJ A;  4GTX A;  3T00 A;  2D1G A;  5KXA A;  1KH4 A;  3NKO A;  5TJ3 A;  2GSU A;  5GOV A;  4UOP A;  1HQA A;  3Q3Q A;  5C66 A;  4ZGA A;  1E3C P;  1EW9 A;  3IDD A;  4ZG6 A;  3SZZ A;  3WAX A;  3BDG A;  4UPI A;  3MK1 A;  3BDG B;  3CMR A;  3IGY B;  3NKN A;  4LR9 A;  1EW8 A;  1HJK A;  1P49 A;  3NKM A;  1AJB A;  1AJA A;  2GSN A;  2W5S A;  3E2D A;  3NVL A;  4N7T A;  4QAX A;  4TN0 A;  5HRT A;  2X98 A;  4YR1 A;  3M8W A;  5AJ9 A;  1ALH A;  2VQR A;  1HDH A;  3KD8 A;  4UOR A;  5EGH A;  4KAV A;  3TWZ A;  5GRR A;  1ANJ A;  2W8D A;  1O98 A;  1URB A;  1EW2 A;  3A52 A;  3BDF A;  4NWX A;  5L0B A;  2W5X A;  1N2K A;  4CXS A;  1FSU A;  5LRM A;  1E33 P;  3TG0 A;  3SZY A;  5LIA A;  3BDH A;  2RH6 A;  4ZG7 A;  3M7V A;  3MK2 A;  2GLQ A;  4GTY A;  2IUC B;  2IFY A;  4UPK A;  5EGE A;  2GSO A;  2W5W A;  2W8S A;  1ELY A;  3UN5 A;  3WBH A;  1AJC A;  4KJG A;  3M8Z A;  3T02 A;  1K7H A;  3WAY A;  4NWJ A;  1E2S P;  1ELX A;  3UN2 A;  5L0E A;  4GTZ A;  1KH7 A;  4LRC A;  4LRD A;  3UO0 A;  3UN3 A;  4MY4 A;  1EI6 A;  3TX0 A;  1ED9 A;  1ALI A;  4UPL A;  4GTW A;  1AJD A;  4CYS A;  2IUC A;  4ZG9 A;  1ELZ A;  2XRG A;  4KAY A;  4LRE A;  5LQQ A;  5IJS A;  1KHK A;  4MHX A;  1E1Z P;  3NKP A;  4CYR A;  1URA A;  4LR8 A;  1O99 A;  1Y7A A;  5K4P A;  1EJJ A;  1SHN A;  1KH9 A;  4LQY A;  4UOO A;  3DPC A;  4KJD A;  1ZED A;  3LXQ A;  3T01 A;  3MK0 A;  5DLT A;  5INH A;  5DLW A;  3IGZ B;  4CXK A;  1ZEB A;  4LR2 A;  2W5R A;  1ZEF A;  2XR9 A;  1ED8 A;  2GA3 A;  4LRF A;  1B8J A;  1SHQ A;  2G9Y A;  3ED4 A;  4UPH A;  4MIV A;  1ALK A;  4LRA A;  2W5Q A;  3WAW A;  5IJQ A;  1ALJ A;  3M8Y A;  4FDJ A;  3WAV A;  3NKQ A;  4LR7 A;  1AUK A;  1KH5 A;  2ANH A;  4LRB A;  2W5V A;  5DLV A;  1KHL A; 
#chains in the Genus database with same CATH topology
 5L0K A;  3DYC A;  4KM4 A;  3NKR A;  4FDI A;  1KHN A;  4CXU A;  1KHJ A;  2W5T A;  1ANI A;  2ZKT A;  1N2L A;  4B56 A;  3B5Q A;  5LRN A;  2QZU A;  3OT9 A;  1Y6V A;  3UNY A;  1EQJ A;  4GTX A;  3T00 A;  2D1G A;  5KXA A;  1KH4 A;  3NKO A;  5TJ3 A;  2GSU A;  5GOV A;  4UOP A;  1HQA A;  3Q3Q A;  5C66 A;  4ZGA A;  1E3C P;  1EW9 A;  3IDD A;  4ZG6 A;  3SZZ A;  3WAX A;  3BDG A;  4UPI A;  3MK1 A;  3BDG B;  3CMR A;  3IGY B;  3NKN A;  4LR9 A;  1EW8 A;  1HJK A;  1P49 A;  3NKM A;  1AJB A;  1AJA A;  2GSN A;  2W5S A;  3E2D A;  3NVL A;  4N7T A;  4QAX A;  4TN0 A;  5HRT A;  2X98 A;  4YR1 A;  3M8W A;  5AJ9 A;  1ALH A;  2VQR A;  1HDH A;  3KD8 A;  4UOR A;  5EGH A;  4KAV A;  3TWZ A;  5GRR A;  1ANJ A;  2W8D A;  1O98 A;  1URB A;  1EW2 A;  3A52 A;  3BDF A;  4NWX A;  5L0B A;  2W5X A;  1N2K A;  4CXS A;  1FSU A;  5LRM A;  1E33 P;  3TG0 A;  3SZY A;  5LIA A;  3BDH A;  2RH6 A;  4ZG7 A;  3M7V A;  3MK2 A;  2GLQ A;  4GTY A;  2IUC B;  2IFY A;  4UPK A;  5EGE A;  2GSO A;  2W5W A;  2W8S A;  1ELY A;  3UN5 A;  3WBH A;  1AJC A;  4KJG A;  3M8Z A;  3T02 A;  1K7H A;  3WAY A;  4NWJ A;  1E2S P;  1ELX A;  3UN2 A;  5L0E A;  4GTZ A;  1KH7 A;  4LRC A;  4LRD A;  3UO0 A;  3UN3 A;  4MY4 A;  1EI6 A;  3TX0 A;  1ED9 A;  1ALI A;  4UPL A;  4GTW A;  1AJD A;  4CYS A;  2IUC A;  4ZG9 A;  1ELZ A;  2XRG A;  4KAY A;  4LRE A;  5LQQ A;  5IJS A;  1KHK A;  4MHX A;  1E1Z P;  3NKP A;  4CYR A;  1URA A;  4LR8 A;  1O99 A;  1Y7A A;  5K4P A;  1EJJ A;  1SHN A;  1KH9 A;  4LQY A;  4UOO A;  3DPC A;  4KJD A;  1ZED A;  3LXQ A;  3T01 A;  3MK0 A;  5DLT A;  5INH A;  5DLW A;  3IGZ B;  4CXK A;  1ZEB A;  4LR2 A;  2W5R A;  1ZEF A;  2XR9 A;  1ED8 A;  2GA3 A;  4LRF A;  1B8J A;  1SHQ A;  2G9Y A;  3ED4 A;  4UPH A;  4MIV A;  1ALK A;  4LRA A;  2W5Q A;  3WAW A;  5IJQ A;  1ALJ A;  3M8Y A;  4FDJ A;  3WAV A;  3NKQ A;  4LR7 A;  1AUK A;  1KH5 A;  2ANH A;  4LRB A;  2W5V A;  5DLV A;  1KHL A; 
#chains in the Genus database with same CATH homology
 5L0K A;  3DYC A;  4KM4 A;  3NKR A;  4FDI A;  1KHN A;  4CXU A;  1KHJ A;  2W5T A;  1ANI A;  2ZKT A;  1N2L A;  4B56 A;  3B5Q A;  5LRN A;  2QZU A;  3OT9 A;  1Y6V A;  3UNY A;  1EQJ A;  4GTX A;  3T00 A;  2D1G A;  5KXA A;  1KH4 A;  3NKO A;  5TJ3 A;  2GSU A;  5GOV A;  4UOP A;  1HQA A;  3Q3Q A;  5C66 A;  4ZGA A;  1E3C P;  1EW9 A;  3IDD A;  4ZG6 A;  3SZZ A;  3WAX A;  3BDG A;  4UPI A;  3MK1 A;  3BDG B;  3CMR A;  3IGY B;  3NKN A;  4LR9 A;  1EW8 A;  1HJK A;  1P49 A;  3NKM A;  1AJB A;  1AJA A;  2GSN A;  2W5S A;  3E2D A;  3NVL A;  4N7T A;  4QAX A;  4TN0 A;  5HRT A;  2X98 A;  4YR1 A;  3M8W A;  5AJ9 A;  1ALH A;  2VQR A;  1HDH A;  3KD8 A;  4UOR A;  5EGH A;  4KAV A;  3TWZ A;  5GRR A;  1ANJ A;  2W8D A;  1O98 A;  1URB A;  1EW2 A;  3A52 A;  3BDF A;  4NWX A;  5L0B A;  2W5X A;  1N2K A;  4CXS A;  1FSU A;  5LRM A;  1E33 P;  3TG0 A;  3SZY A;  5LIA A;  3BDH A;  2RH6 A;  4ZG7 A;  3M7V A;  3MK2 A;  2GLQ A;  4GTY A;  2IUC B;  2IFY A;  4UPK A;  5EGE A;  2GSO A;  2W5W A;  2W8S A;  1ELY A;  3UN5 A;  3WBH A;  1AJC A;  4KJG A;  3M8Z A;  3T02 A;  1K7H A;  3WAY A;  4NWJ A;  1E2S P;  1ELX A;  3UN2 A;  5L0E A;  4GTZ A;  1KH7 A;  4LRC A;  4LRD A;  3UO0 A;  3UN3 A;  4MY4 A;  1EI6 A;  3TX0 A;  1ED9 A;  1ALI A;  4UPL A;  4GTW A;  1AJD A;  4CYS A;  2IUC A;  4ZG9 A;  1ELZ A;  2XRG A;  4KAY A;  4LRE A;  5LQQ A;  5IJS A;  1KHK A;  4MHX A;  1E1Z P;  3NKP A;  4CYR A;  1URA A;  4LR8 A;  1O99 A;  1Y7A A;  5K4P A;  1EJJ A;  1SHN A;  1KH9 A;  4LQY A;  4UOO A;  3DPC A;  4KJD A;  1ZED A;  3LXQ A;  3T01 A;  3MK0 A;  5DLT A;  5INH A;  5DLW A;  3IGZ B;  4CXK A;  1ZEB A;  4LR2 A;  2W5R A;  1ZEF A;  2XR9 A;  1ED8 A;  2GA3 A;  4LRF A;  1B8J A;  1SHQ A;  2G9Y A;  3ED4 A;  4UPH A;  4MIV A;  1ALK A;  4LRA A;  2W5Q A;  3WAW A;  5IJQ A;  1ALJ A;  3M8Y A;  4FDJ A;  3WAV A;  3NKQ A;  4LR7 A;  1AUK A;  1KH5 A;  2ANH A;  4LRB A;  2W5V A;  5DLV A;  1KHL A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...