3MK0A

Refinement of placental alkaline phosphatase complexed with nitrophenyl
Total Genus 178
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
178
Knots found
sequence length
481
structure length
480
Chain Sequence
b'IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase, placental type
publication title Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
pubmed doi rcsb
molecule tags Hydrolase
total genus 178
structure length 480
sequence length 481
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2010-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 3mk0A00
1ZEDA 5EGHA 1HDHA 3DPCA 1FSUA 3WAYA 1E33P 3SZZA 1HQAA 1AJDA 1EI6A 1B8JA 1N2LA 1EW8A 3NKQA 1EW9A 4UPLA 2IUCA 1P49A 2X98A 3MK0A 2W5SA 3T01A 1ANIA 4LQYA 2W8DA 2W5WA 1HJKA 2GA3A 3B5QA 1ALJA 4FDIA 1SHNA 4UOPA 4FDJA 4N7TA 1KH7A 2W5QA 5GOVA 1E1ZP 4UORA 4UPHA 1ALKA 4MY4A 4CXUA 2W5RA 4GTZA 2QZUA 4LR7A 3BDFA 1ALHA 3LXQA 4LREA 2IUCB 2GLQA 3NKPA 4KAYA 3UN3A 5LRMA 5DLWA 2GSOA 3NKNA 4GTYA 4CXSA 4CYRA 3T00A 4UOOA 2G9YA 4MHXA 2XR9A 1ED8A 1EJJA 1KH4A 1SHQA 3NKMA 4MIVA 5L0EA 4ZG9A 4UPKA 2W5XA 1KH5A 3DYCA 3IGZB 4GTWA 5K4PA 1E3CP 5EGEA 4LRCA 1O99A 1E2SP 4UPIA 3A52A 4KJGA 2W5TA 3ED4A 3UO0A 3T02A 1AUKA 3UNYA 3NVLA 1O98A 3WAXA 1ZEFA 5LRNA 1KHNA 4QAXA 4LRDA 2RH6A 2W5VA 3IGYB 4ZG6A 5DLVA 3TWZA 3TG0A 4LR8A 3BDHA 2GSNA 4NWJA 3SZYA 5KXAA 3WAVA 1KHLA 5DLTA 4CXKA 4KJDA 4ZGAA 4KAVA 1EQJA 3UN2A 3M8WA 5L0KA 2D1GA 1ED9A 3MK1A 3NKOA 5GRRA 4LRBA 2W8SA 3BDGB 1EW2A 5INHA 3TX0A 1ALIA 5L0BA 3WAWA 3IDDA 1ELYA 1AJBA 4KM4A 4CYSA 5LIAA 1AJAA 3MK2A 3UN5A 5IJQA 2XRGA 1N2KA 1ANJA 3CMRA 4LR9A 3BDGA 4TN0A 3KD8A 1URBA 3M7VA 4ZG7A 4LR2A 3E2DA 4LRAA 4NWXA 4LRFA 4YR1A 3NKRA 1K7HA 1KHJA 2ZKTA 5LQQA 1URAA 3M8YA 5IJSA 2VQRA 1ZEBA 5TJ3A 1ELXA 1KHKA 2ANHA 5C66A 1KH9A 3M8ZA 4B56A 5HRTA 3OT9A 2IFYA 2GSUA 3WBHA 1ELZA 4GTXA 3Q3QA 1Y7AA 1AJCA 1Y6VA 5AJ9A
chains in the Genus database with same CATH superfamily
1ZEDA 5EGHA 1HDHA 3DPCA 1FSUA 3WAYA 1E33P 3SZZA 1HQAA 1AJDA 1EI6A 1B8JA 1N2LA 1EW8A 3NKQA 1EW9A 4UPLA 2IUCA 1P49A 2X98A 3MK0A 2W5SA 3T01A 1ANIA 4LQYA 2W8DA 2W5WA 1HJKA 2GA3A 3B5QA 1ALJA 4FDIA 1SHNA 4UOPA 4FDJA 4N7TA 1KH7A 2W5QA 5GOVA 1E1ZP 4UORA 4UPHA 1ALKA 4MY4A 4CXUA 2W5RA 4GTZA 2QZUA 4LR7A 3BDFA 1ALHA 3LXQA 4LREA 2IUCB 2GLQA 3NKPA 4KAYA 3UN3A 5LRMA 5DLWA 2GSOA 3NKNA 4GTYA 4CXSA 4CYRA 3T00A 4UOOA 2G9YA 4MHXA 2XR9A 1ED8A 1EJJA 1KH4A 1SHQA 3NKMA 4MIVA 5L0EA 4ZG9A 4UPKA 2W5XA 1KH5A 3DYCA 3IGZB 4GTWA 5K4PA 1E3CP 5EGEA 4LRCA 1O99A 1E2SP 4UPIA 3A52A 4KJGA 2W5TA 3ED4A 3UO0A 3T02A 1AUKA 3UNYA 3NVLA 1O98A 3WAXA 1ZEFA 5LRNA 1KHNA 4QAXA 4LRDA 2RH6A 2W5VA 3IGYB 4ZG6A 5DLVA 3TWZA 3TG0A 4LR8A 3BDHA 2GSNA 4NWJA 3SZYA 5KXAA 3WAVA 1KHLA 5DLTA 4CXKA 4KJDA 4ZGAA 4KAVA 1EQJA 3UN2A 3M8WA 5L0KA 2D1GA 1ED9A 3MK1A 3NKOA 5GRRA 4LRBA 2W8SA 3BDGB 1EW2A 5INHA 3TX0A 1ALIA 5L0BA 3WAWA 3IDDA 1ELYA 1AJBA 4KM4A 4CYSA 5LIAA 1AJAA 3MK2A 3UN5A 5IJQA 2XRGA 1N2KA 1ANJA 3CMRA 4LR9A 3BDGA 4TN0A 3KD8A 1URBA 3M7VA 4ZG7A 4LR2A 3E2DA 4LRAA 4NWXA 4LRFA 4YR1A 3NKRA 1K7HA 1KHJA 2ZKTA 5LQQA 1URAA 3M8YA 5IJSA 2VQRA 1ZEBA 5TJ3A 1ELXA 1KHKA 2ANHA 5C66A 1KH9A 3M8ZA 4B56A 5HRTA 3OT9A 2IFYA 2GSUA 3WBHA 1ELZA 4GTXA 3Q3QA 1Y7AA 1AJCA 1Y6VA 5AJ9A
chains in the Genus database with same CATH topology
1ZEDA 5EGHA 1HDHA 3DPCA 1FSUA 3WAYA 1E33P 3SZZA 1HQAA 1AJDA 1EI6A 1B8JA 1N2LA 1EW8A 3NKQA 1EW9A 4UPLA 2IUCA 1P49A 2X98A 3MK0A 2W5SA 3T01A 1ANIA 4LQYA 2W8DA 2W5WA 1HJKA 2GA3A 3B5QA 1ALJA 4FDIA 1SHNA 4UOPA 4FDJA 4N7TA 1KH7A 2W5QA 5GOVA 1E1ZP 4UORA 4UPHA 1ALKA 4MY4A 4CXUA 2W5RA 4GTZA 2QZUA 4LR7A 3BDFA 1ALHA 3LXQA 4LREA 2IUCB 2GLQA 3NKPA 4KAYA 3UN3A 5LRMA 5DLWA 2GSOA 3NKNA 4GTYA 4CXSA 4CYRA 3T00A 4UOOA 2G9YA 4MHXA 2XR9A 1ED8A 1EJJA 1KH4A 1SHQA 3NKMA 4MIVA 5L0EA 4ZG9A 4UPKA 2W5XA 1KH5A 3DYCA 3IGZB 4GTWA 5K4PA 1E3CP 5EGEA 4LRCA 1O99A 1E2SP 4UPIA 3A52A 4KJGA 2W5TA 3ED4A 3UO0A 3T02A 1AUKA 3UNYA 3NVLA 1O98A 3WAXA 1ZEFA 5LRNA 1KHNA 4QAXA 4LRDA 2RH6A 2W5VA 3IGYB 4ZG6A 5DLVA 3TWZA 3TG0A 4LR8A 3BDHA 2GSNA 4NWJA 3SZYA 5KXAA 3WAVA 1KHLA 5DLTA 4CXKA 4KJDA 4ZGAA 4KAVA 1EQJA 3UN2A 3M8WA 5L0KA 2D1GA 1ED9A 3MK1A 3NKOA 5GRRA 4LRBA 2W8SA 3BDGB 1EW2A 5INHA 3TX0A 1ALIA 5L0BA 3WAWA 3IDDA 1ELYA 1AJBA 4KM4A 4CYSA 5LIAA 1AJAA 3MK2A 3UN5A 5IJQA 2XRGA 1N2KA 1ANJA 3CMRA 4LR9A 3BDGA 4TN0A 3KD8A 1URBA 3M7VA 4ZG7A 4LR2A 3E2DA 4LRAA 4NWXA 4LRFA 4YR1A 3NKRA 1K7HA 1KHJA 2ZKTA 5LQQA 1URAA 3M8YA 5IJSA 2VQRA 1ZEBA 5TJ3A 1ELXA 1KHKA 2ANHA 5C66A 1KH9A 3M8ZA 4B56A 5HRTA 3OT9A 2IFYA 2GSUA 3WBHA 1ELZA 4GTXA 3Q3QA 1Y7AA 1AJCA 1Y6VA 5AJ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1ZED A;  5EGH A;  1HDH A;  3DPC A;  1FSU A;  3WAY A;  1E33 P;  3SZZ A;  1HQA A;  1AJD A;  1EI6 A;  1B8J A;  1N2L A;  1EW8 A;  3NKQ A;  1EW9 A;  4UPL A;  2IUC A;  1P49 A;  2X98 A;  3MK0 A;  2W5S A;  3T01 A;  1ANI A;  4LQY A;  2W8D A;  2W5W A;  1HJK A;  2GA3 A;  3B5Q A;  1ALJ A;  4FDI A;  1SHN A;  4UOP A;  4FDJ A;  4N7T A;  1KH7 A;  2W5Q A;  5GOV A;  1E1Z P;  4UOR A;  4UPH A;  1ALK A;  4MY4 A;  4CXU A;  2W5R A;  4GTZ A;  2QZU A;  4LR7 A;  3BDF A;  1ALH A;  3LXQ A;  4LRE A;  2IUC B;  2GLQ A;  3NKP A;  4KAY A;  3UN3 A;  5LRM A;  5DLW A;  2GSO A;  3NKN A;  4GTY A;  4CXS A;  4CYR A;  3T00 A;  4UOO A;  2G9Y A;  4MHX A;  2XR9 A;  1ED8 A;  1EJJ A;  1KH4 A;  1SHQ A;  3NKM A;  4MIV A;  5L0E A;  4ZG9 A;  4UPK A;  2W5X A;  1KH5 A;  3DYC A;  3IGZ B;  4GTW A;  5K4P A;  1E3C P;  5EGE A;  4LRC A;  1O99 A;  1E2S P;  4UPI A;  3A52 A;  4KJG A;  2W5T A;  3ED4 A;  3UO0 A;  3T02 A;  1AUK A;  3UNY A;  3NVL A;  1O98 A;  3WAX A;  1ZEF A;  5LRN A;  1KHN A;  4QAX A;  4LRD A;  2RH6 A;  2W5V A;  3IGY B;  4ZG6 A;  5DLV A;  3TWZ A;  3TG0 A;  4LR8 A;  3BDH A;  2GSN A;  4NWJ A;  3SZY A;  5KXA A;  3WAV A;  1KHL A;  5DLT A;  4CXK A;  4KJD A;  4ZGA A;  4KAV A;  1EQJ A;  3UN2 A;  3M8W A;  5L0K A;  2D1G A;  1ED9 A;  3MK1 A;  3NKO A;  5GRR A;  4LRB A;  2W8S A;  3BDG B;  1EW2 A;  5INH A;  3TX0 A;  1ALI A;  5L0B A;  3WAW A;  3IDD A;  1ELY A;  1AJB A;  4KM4 A;  4CYS A;  5LIA A;  1AJA A;  3MK2 A;  3UN5 A;  5IJQ A;  2XRG A;  1N2K A;  1ANJ A;  3CMR A;  4LR9 A;  3BDG A;  4TN0 A;  3KD8 A;  1URB A;  3M7V A;  4ZG7 A;  4LR2 A;  3E2D A;  4LRA A;  4NWX A;  4LRF A;  4YR1 A;  3NKR A;  1K7H A;  1KHJ A;  2ZKT A;  5LQQ A;  1URA A;  3M8Y A;  5IJS A;  2VQR A;  1ZEB A;  5TJ3 A;  1ELX A;  1KHK A;  2ANH A;  5C66 A;  1KH9 A;  3M8Z A;  4B56 A;  5HRT A;  3OT9 A;  2IFY A;  2GSU A;  3WBH A;  1ELZ A;  4GTX A;  3Q3Q A;  1Y7A A;  1AJC A;  1Y6V A;  5AJ9 A; 
#chains in the Genus database with same CATH topology
 1ZED A;  5EGH A;  1HDH A;  3DPC A;  1FSU A;  3WAY A;  1E33 P;  3SZZ A;  1HQA A;  1AJD A;  1EI6 A;  1B8J A;  1N2L A;  1EW8 A;  3NKQ A;  1EW9 A;  4UPL A;  2IUC A;  1P49 A;  2X98 A;  3MK0 A;  2W5S A;  3T01 A;  1ANI A;  4LQY A;  2W8D A;  2W5W A;  1HJK A;  2GA3 A;  3B5Q A;  1ALJ A;  4FDI A;  1SHN A;  4UOP A;  4FDJ A;  4N7T A;  1KH7 A;  2W5Q A;  5GOV A;  1E1Z P;  4UOR A;  4UPH A;  1ALK A;  4MY4 A;  4CXU A;  2W5R A;  4GTZ A;  2QZU A;  4LR7 A;  3BDF A;  1ALH A;  3LXQ A;  4LRE A;  2IUC B;  2GLQ A;  3NKP A;  4KAY A;  3UN3 A;  5LRM A;  5DLW A;  2GSO A;  3NKN A;  4GTY A;  4CXS A;  4CYR A;  3T00 A;  4UOO A;  2G9Y A;  4MHX A;  2XR9 A;  1ED8 A;  1EJJ A;  1KH4 A;  1SHQ A;  3NKM A;  4MIV A;  5L0E A;  4ZG9 A;  4UPK A;  2W5X A;  1KH5 A;  3DYC A;  3IGZ B;  4GTW A;  5K4P A;  1E3C P;  5EGE A;  4LRC A;  1O99 A;  1E2S P;  4UPI A;  3A52 A;  4KJG A;  2W5T A;  3ED4 A;  3UO0 A;  3T02 A;  1AUK A;  3UNY A;  3NVL A;  1O98 A;  3WAX A;  1ZEF A;  5LRN A;  1KHN A;  4QAX A;  4LRD A;  2RH6 A;  2W5V A;  3IGY B;  4ZG6 A;  5DLV A;  3TWZ A;  3TG0 A;  4LR8 A;  3BDH A;  2GSN A;  4NWJ A;  3SZY A;  5KXA A;  3WAV A;  1KHL A;  5DLT A;  4CXK A;  4KJD A;  4ZGA A;  4KAV A;  1EQJ A;  3UN2 A;  3M8W A;  5L0K A;  2D1G A;  1ED9 A;  3MK1 A;  3NKO A;  5GRR A;  4LRB A;  2W8S A;  3BDG B;  1EW2 A;  5INH A;  3TX0 A;  1ALI A;  5L0B A;  3WAW A;  3IDD A;  1ELY A;  1AJB A;  4KM4 A;  4CYS A;  5LIA A;  1AJA A;  3MK2 A;  3UN5 A;  5IJQ A;  2XRG A;  1N2K A;  1ANJ A;  3CMR A;  4LR9 A;  3BDG A;  4TN0 A;  3KD8 A;  1URB A;  3M7V A;  4ZG7 A;  4LR2 A;  3E2D A;  4LRA A;  4NWX A;  4LRF A;  4YR1 A;  3NKR A;  1K7H A;  1KHJ A;  2ZKT A;  5LQQ A;  1URA A;  3M8Y A;  5IJS A;  2VQR A;  1ZEB A;  5TJ3 A;  1ELX A;  1KHK A;  2ANH A;  5C66 A;  1KH9 A;  3M8Z A;  4B56 A;  5HRT A;  3OT9 A;  2IFY A;  2GSU A;  3WBH A;  1ELZ A;  4GTX A;  3Q3Q A;  1Y7A A;  1AJC A;  1Y6V A;  5AJ9 A; 
#chains in the Genus database with same CATH homology
 1ZED A;  5EGH A;  1HDH A;  3DPC A;  1FSU A;  3WAY A;  1E33 P;  3SZZ A;  1HQA A;  1AJD A;  1EI6 A;  1B8J A;  1N2L A;  1EW8 A;  3NKQ A;  1EW9 A;  4UPL A;  2IUC A;  1P49 A;  2X98 A;  3MK0 A;  2W5S A;  3T01 A;  1ANI A;  4LQY A;  2W8D A;  2W5W A;  1HJK A;  2GA3 A;  3B5Q A;  1ALJ A;  4FDI A;  1SHN A;  4UOP A;  4FDJ A;  4N7T A;  1KH7 A;  2W5Q A;  5GOV A;  1E1Z P;  4UOR A;  4UPH A;  1ALK A;  4MY4 A;  4CXU A;  2W5R A;  4GTZ A;  2QZU A;  4LR7 A;  3BDF A;  1ALH A;  3LXQ A;  4LRE A;  2IUC B;  2GLQ A;  3NKP A;  4KAY A;  3UN3 A;  5LRM A;  5DLW A;  2GSO A;  3NKN A;  4GTY A;  4CXS A;  4CYR A;  3T00 A;  4UOO A;  2G9Y A;  4MHX A;  2XR9 A;  1ED8 A;  1EJJ A;  1KH4 A;  1SHQ A;  3NKM A;  4MIV A;  5L0E A;  4ZG9 A;  4UPK A;  2W5X A;  1KH5 A;  3DYC A;  3IGZ B;  4GTW A;  5K4P A;  1E3C P;  5EGE A;  4LRC A;  1O99 A;  1E2S P;  4UPI A;  3A52 A;  4KJG A;  2W5T A;  3ED4 A;  3UO0 A;  3T02 A;  1AUK A;  3UNY A;  3NVL A;  1O98 A;  3WAX A;  1ZEF A;  5LRN A;  1KHN A;  4QAX A;  4LRD A;  2RH6 A;  2W5V A;  3IGY B;  4ZG6 A;  5DLV A;  3TWZ A;  3TG0 A;  4LR8 A;  3BDH A;  2GSN A;  4NWJ A;  3SZY A;  5KXA A;  3WAV A;  1KHL A;  5DLT A;  4CXK A;  4KJD A;  4ZGA A;  4KAV A;  1EQJ A;  3UN2 A;  3M8W A;  5L0K A;  2D1G A;  1ED9 A;  3MK1 A;  3NKO A;  5GRR A;  4LRB A;  2W8S A;  3BDG B;  1EW2 A;  5INH A;  3TX0 A;  1ALI A;  5L0B A;  3WAW A;  3IDD A;  1ELY A;  1AJB A;  4KM4 A;  4CYS A;  5LIA A;  1AJA A;  3MK2 A;  3UN5 A;  5IJQ A;  2XRG A;  1N2K A;  1ANJ A;  3CMR A;  4LR9 A;  3BDG A;  4TN0 A;  3KD8 A;  1URB A;  3M7V A;  4ZG7 A;  4LR2 A;  3E2D A;  4LRA A;  4NWX A;  4LRF A;  4YR1 A;  3NKR A;  1K7H A;  1KHJ A;  2ZKT A;  5LQQ A;  1URA A;  3M8Y A;  5IJS A;  2VQR A;  1ZEB A;  5TJ3 A;  1ELX A;  1KHK A;  2ANH A;  5C66 A;  1KH9 A;  3M8Z A;  4B56 A;  5HRT A;  3OT9 A;  2IFY A;  2GSU A;  3WBH A;  1ELZ A;  4GTX A;  3Q3Q A;  1Y7A A;  1AJC A;  1Y6V A;  5AJ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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