1URAA

Alkaline phosphatase (d51zn)
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGNGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1996-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1uraA00
2ANHA 1KH5A 3M8WA 2W5XA 4N7TA 2W5WA 4KJDA 2IUCB 5KXAA 1ANJA 1KH9A 1ALHA 4GTZA 3TX0A 4UOOA 1ZEDA 1AUKA 1KH4A 4B56A 4FDJA 5DLVA 3NKOA 5EGEA 3MK2A 5K4PA 4NWJA 5EGHA 3DYCA 4LR9A 4ZG9A 1KHKA 1ZEBA 3BDFA 3IGYB 3Q3QA 1ALKA 3NVLA 3WAVA 3UN5A 2G9YA 1B8JA 1EI6A 2GA3A 1SHNA 1ANIA 2W5TA 1URAA 3IGZB 3A52A 1AJBA 2GLQA 2IFYA 3BDHA 3SZYA 3BDGB 1ED9A 1E2SP 4LRAA 1O98A 1N2LA 4KJGA 4UORA 4ZG7A 1E33P 3M7VA 1ELXA 1N2KA 2X98A 1AJAA 5LRMA 4LQYA 4LR8A 4ZG6A 4LRBA 4KAVA 5LIAA 1KHNA 3M8ZA 2QZUA 3UN3A 3KD8A 4CXKA 4KM4A 5IJSA 5LQQA 1KHJA 4QAXA 3TWZA 1EW9A 1Y7AA 2IUCA 3WBHA 4ZGAA 1ELZA 1EW8A 1AJDA 4MIVA 3WAYA 1ALIA 4UOPA 4MHXA 3OT9A 1KH7A 3NKMA 4GTWA 4LRFA 5DLWA 3MK1A 4UPLA 1EJJA 3NKRA 4LRDA 2W5VA 1EQJA 4FDIA 1HDHA 2ZKTA 4MY4A 1P49A 5AJ9A 2W8SA 2GSUA 5IJQA 2XR9A 5L0EA 1ZEFA 4CXUA 4CYSA 5TJ3A 2W5SA 4UPHA 5GOVA 2W5QA 3T00A 4LREA 3SZZA 3UN2A 3NKQA 3LXQA 3MK0A 1HJKA 1EW2A 2D1GA 4GTYA 4YR1A 3TG0A 4LR2A 2RH6A 3WAWA 3NKPA 1FSUA 4CXSA 1KHLA 1K7HA 4GTXA 1HQAA 1E3CP 2W5RA 3IDDA 5C66A 5HRTA 1SHQA 5DLTA 1Y6VA 3DPCA 4LR7A 4KAYA 2W8DA 4LRCA 3ED4A 3WAXA 2VQRA 3UNYA 4TN0A 5L0KA 3E2DA 3NKNA 1ED8A 3B5QA 3M8YA 1URBA 4UPIA 1O99A 3UO0A 2XRGA 3CMRA 1ALJA 1E1ZP 3BDGA 5L0BA 4CYRA 4NWXA 4UPKA 2GSOA 1ELYA 2GSNA 5INHA 3T02A 5GRRA 3T01A 5LRNA 1AJCA
chains in the Genus database with same CATH superfamily
2ANHA 1KH5A 3M8WA 2W5XA 4N7TA 2W5WA 4KJDA 2IUCB 5KXAA 1ANJA 1KH9A 1ALHA 4GTZA 3TX0A 4UOOA 1ZEDA 1AUKA 1KH4A 4B56A 4FDJA 5DLVA 3NKOA 5EGEA 3MK2A 5K4PA 4NWJA 5EGHA 3DYCA 4LR9A 4ZG9A 1KHKA 1ZEBA 3BDFA 3IGYB 3Q3QA 1ALKA 3NVLA 3WAVA 3UN5A 2G9YA 1B8JA 1EI6A 2GA3A 1SHNA 1ANIA 2W5TA 1URAA 3IGZB 3A52A 1AJBA 2GLQA 2IFYA 3BDHA 3SZYA 3BDGB 1ED9A 1E2SP 4LRAA 1O98A 1N2LA 4KJGA 4UORA 4ZG7A 1E33P 3M7VA 1ELXA 1N2KA 2X98A 1AJAA 5LRMA 4LQYA 4LR8A 4ZG6A 4LRBA 4KAVA 5LIAA 1KHNA 3M8ZA 2QZUA 3UN3A 3KD8A 4CXKA 4KM4A 5IJSA 5LQQA 1KHJA 4QAXA 3TWZA 1EW9A 1Y7AA 2IUCA 3WBHA 4ZGAA 1ELZA 1EW8A 1AJDA 4MIVA 3WAYA 1ALIA 4UOPA 4MHXA 3OT9A 1KH7A 3NKMA 4GTWA 4LRFA 5DLWA 3MK1A 4UPLA 1EJJA 3NKRA 4LRDA 2W5VA 1EQJA 4FDIA 1HDHA 2ZKTA 4MY4A 1P49A 5AJ9A 2W8SA 2GSUA 5IJQA 2XR9A 5L0EA 1ZEFA 4CXUA 4CYSA 5TJ3A 2W5SA 4UPHA 5GOVA 2W5QA 3T00A 4LREA 3SZZA 3UN2A 3NKQA 3LXQA 3MK0A 1HJKA 1EW2A 2D1GA 4GTYA 4YR1A 3TG0A 4LR2A 2RH6A 3WAWA 3NKPA 1FSUA 4CXSA 1KHLA 1K7HA 4GTXA 1HQAA 1E3CP 2W5RA 3IDDA 5C66A 5HRTA 1SHQA 5DLTA 1Y6VA 3DPCA 4LR7A 4KAYA 2W8DA 4LRCA 3ED4A 3WAXA 2VQRA 3UNYA 4TN0A 5L0KA 3E2DA 3NKNA 1ED8A 3B5QA 3M8YA 1URBA 4UPIA 1O99A 3UO0A 2XRGA 3CMRA 1ALJA 1E1ZP 3BDGA 5L0BA 4CYRA 4NWXA 4UPKA 2GSOA 1ELYA 2GSNA 5INHA 3T02A 5GRRA 3T01A 5LRNA 1AJCA
chains in the Genus database with same CATH topology
2ANHA 1KH5A 3M8WA 2W5XA 4N7TA 2W5WA 4KJDA 2IUCB 5KXAA 1ANJA 1KH9A 1ALHA 4GTZA 3TX0A 4UOOA 1ZEDA 1AUKA 1KH4A 4B56A 4FDJA 5DLVA 3NKOA 5EGEA 3MK2A 5K4PA 4NWJA 5EGHA 3DYCA 4LR9A 4ZG9A 1KHKA 1ZEBA 3BDFA 3IGYB 3Q3QA 1ALKA 3NVLA 3WAVA 3UN5A 2G9YA 1B8JA 1EI6A 2GA3A 1SHNA 1ANIA 2W5TA 1URAA 3IGZB 3A52A 1AJBA 2GLQA 2IFYA 3BDHA 3SZYA 3BDGB 1ED9A 1E2SP 4LRAA 1O98A 1N2LA 4KJGA 4UORA 4ZG7A 1E33P 3M7VA 1ELXA 1N2KA 2X98A 1AJAA 5LRMA 4LQYA 4LR8A 4ZG6A 4LRBA 4KAVA 5LIAA 1KHNA 3M8ZA 2QZUA 3UN3A 3KD8A 4CXKA 4KM4A 5IJSA 5LQQA 1KHJA 4QAXA 3TWZA 1EW9A 1Y7AA 2IUCA 3WBHA 4ZGAA 1ELZA 1EW8A 1AJDA 4MIVA 3WAYA 1ALIA 4UOPA 4MHXA 3OT9A 1KH7A 3NKMA 4GTWA 4LRFA 5DLWA 3MK1A 4UPLA 1EJJA 3NKRA 4LRDA 2W5VA 1EQJA 4FDIA 1HDHA 2ZKTA 4MY4A 1P49A 5AJ9A 2W8SA 2GSUA 5IJQA 2XR9A 5L0EA 1ZEFA 4CXUA 4CYSA 5TJ3A 2W5SA 4UPHA 5GOVA 2W5QA 3T00A 4LREA 3SZZA 3UN2A 3NKQA 3LXQA 3MK0A 1HJKA 1EW2A 2D1GA 4GTYA 4YR1A 3TG0A 4LR2A 2RH6A 3WAWA 3NKPA 1FSUA 4CXSA 1KHLA 1K7HA 4GTXA 1HQAA 1E3CP 2W5RA 3IDDA 5C66A 5HRTA 1SHQA 5DLTA 1Y6VA 3DPCA 4LR7A 4KAYA 2W8DA 4LRCA 3ED4A 3WAXA 2VQRA 3UNYA 4TN0A 5L0KA 3E2DA 3NKNA 1ED8A 3B5QA 3M8YA 1URBA 4UPIA 1O99A 3UO0A 2XRGA 3CMRA 1ALJA 1E1ZP 3BDGA 5L0BA 4CYRA 4NWXA 4UPKA 2GSOA 1ELYA 2GSNA 5INHA 3T02A 5GRRA 3T01A 5LRNA 1AJCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ANH A;  1KH5 A;  3M8W A;  2W5X A;  4N7T A;  2W5W A;  4KJD A;  2IUC B;  5KXA A;  1ANJ A;  1KH9 A;  1ALH A;  4GTZ A;  3TX0 A;  4UOO A;  1ZED A;  1AUK A;  1KH4 A;  4B56 A;  4FDJ A;  5DLV A;  3NKO A;  5EGE A;  3MK2 A;  5K4P A;  4NWJ A;  5EGH A;  3DYC A;  4LR9 A;  4ZG9 A;  1KHK A;  1ZEB A;  3BDF A;  3IGY B;  3Q3Q A;  1ALK A;  3NVL A;  3WAV A;  3UN5 A;  2G9Y A;  1B8J A;  1EI6 A;  2GA3 A;  1SHN A;  1ANI A;  2W5T A;  1URA A;  3IGZ B;  3A52 A;  1AJB A;  2GLQ A;  2IFY A;  3BDH A;  3SZY A;  3BDG B;  1ED9 A;  1E2S P;  4LRA A;  1O98 A;  1N2L A;  4KJG A;  4UOR A;  4ZG7 A;  1E33 P;  3M7V A;  1ELX A;  1N2K A;  2X98 A;  1AJA A;  5LRM A;  4LQY A;  4LR8 A;  4ZG6 A;  4LRB A;  4KAV A;  5LIA A;  1KHN A;  3M8Z A;  2QZU A;  3UN3 A;  3KD8 A;  4CXK A;  4KM4 A;  5IJS A;  5LQQ A;  1KHJ A;  4QAX A;  3TWZ A;  1EW9 A;  1Y7A A;  2IUC A;  3WBH A;  4ZGA A;  1ELZ A;  1EW8 A;  1AJD A;  4MIV A;  3WAY A;  1ALI A;  4UOP A;  4MHX A;  3OT9 A;  1KH7 A;  3NKM A;  4GTW A;  4LRF A;  5DLW A;  3MK1 A;  4UPL A;  1EJJ A;  3NKR A;  4LRD A;  2W5V A;  1EQJ A;  4FDI A;  1HDH A;  2ZKT A;  4MY4 A;  1P49 A;  5AJ9 A;  2W8S A;  2GSU A;  5IJQ A;  2XR9 A;  5L0E A;  1ZEF A;  4CXU A;  4CYS A;  5TJ3 A;  2W5S A;  4UPH A;  5GOV A;  2W5Q A;  3T00 A;  4LRE A;  3SZZ A;  3UN2 A;  3NKQ A;  3LXQ A;  3MK0 A;  1HJK A;  1EW2 A;  2D1G A;  4GTY A;  4YR1 A;  3TG0 A;  4LR2 A;  2RH6 A;  3WAW A;  3NKP A;  1FSU A;  4CXS A;  1KHL A;  1K7H A;  4GTX A;  1HQA A;  1E3C P;  2W5R A;  3IDD A;  5C66 A;  5HRT A;  1SHQ A;  5DLT A;  1Y6V A;  3DPC A;  4LR7 A;  4KAY A;  2W8D A;  4LRC A;  3ED4 A;  3WAX A;  2VQR A;  3UNY A;  4TN0 A;  5L0K A;  3E2D A;  3NKN A;  1ED8 A;  3B5Q A;  3M8Y A;  1URB A;  4UPI A;  1O99 A;  3UO0 A;  2XRG A;  3CMR A;  1ALJ A;  1E1Z P;  3BDG A;  5L0B A;  4CYR A;  4NWX A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  5INH A;  3T02 A;  5GRR A;  3T01 A;  5LRN A;  1AJC A; 
#chains in the Genus database with same CATH topology
 2ANH A;  1KH5 A;  3M8W A;  2W5X A;  4N7T A;  2W5W A;  4KJD A;  2IUC B;  5KXA A;  1ANJ A;  1KH9 A;  1ALH A;  4GTZ A;  3TX0 A;  4UOO A;  1ZED A;  1AUK A;  1KH4 A;  4B56 A;  4FDJ A;  5DLV A;  3NKO A;  5EGE A;  3MK2 A;  5K4P A;  4NWJ A;  5EGH A;  3DYC A;  4LR9 A;  4ZG9 A;  1KHK A;  1ZEB A;  3BDF A;  3IGY B;  3Q3Q A;  1ALK A;  3NVL A;  3WAV A;  3UN5 A;  2G9Y A;  1B8J A;  1EI6 A;  2GA3 A;  1SHN A;  1ANI A;  2W5T A;  1URA A;  3IGZ B;  3A52 A;  1AJB A;  2GLQ A;  2IFY A;  3BDH A;  3SZY A;  3BDG B;  1ED9 A;  1E2S P;  4LRA A;  1O98 A;  1N2L A;  4KJG A;  4UOR A;  4ZG7 A;  1E33 P;  3M7V A;  1ELX A;  1N2K A;  2X98 A;  1AJA A;  5LRM A;  4LQY A;  4LR8 A;  4ZG6 A;  4LRB A;  4KAV A;  5LIA A;  1KHN A;  3M8Z A;  2QZU A;  3UN3 A;  3KD8 A;  4CXK A;  4KM4 A;  5IJS A;  5LQQ A;  1KHJ A;  4QAX A;  3TWZ A;  1EW9 A;  1Y7A A;  2IUC A;  3WBH A;  4ZGA A;  1ELZ A;  1EW8 A;  1AJD A;  4MIV A;  3WAY A;  1ALI A;  4UOP A;  4MHX A;  3OT9 A;  1KH7 A;  3NKM A;  4GTW A;  4LRF A;  5DLW A;  3MK1 A;  4UPL A;  1EJJ A;  3NKR A;  4LRD A;  2W5V A;  1EQJ A;  4FDI A;  1HDH A;  2ZKT A;  4MY4 A;  1P49 A;  5AJ9 A;  2W8S A;  2GSU A;  5IJQ A;  2XR9 A;  5L0E A;  1ZEF A;  4CXU A;  4CYS A;  5TJ3 A;  2W5S A;  4UPH A;  5GOV A;  2W5Q A;  3T00 A;  4LRE A;  3SZZ A;  3UN2 A;  3NKQ A;  3LXQ A;  3MK0 A;  1HJK A;  1EW2 A;  2D1G A;  4GTY A;  4YR1 A;  3TG0 A;  4LR2 A;  2RH6 A;  3WAW A;  3NKP A;  1FSU A;  4CXS A;  1KHL A;  1K7H A;  4GTX A;  1HQA A;  1E3C P;  2W5R A;  3IDD A;  5C66 A;  5HRT A;  1SHQ A;  5DLT A;  1Y6V A;  3DPC A;  4LR7 A;  4KAY A;  2W8D A;  4LRC A;  3ED4 A;  3WAX A;  2VQR A;  3UNY A;  4TN0 A;  5L0K A;  3E2D A;  3NKN A;  1ED8 A;  3B5Q A;  3M8Y A;  1URB A;  4UPI A;  1O99 A;  3UO0 A;  2XRG A;  3CMR A;  1ALJ A;  1E1Z P;  3BDG A;  5L0B A;  4CYR A;  4NWX A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  5INH A;  3T02 A;  5GRR A;  3T01 A;  5LRN A;  1AJC A; 
#chains in the Genus database with same CATH homology
 2ANH A;  1KH5 A;  3M8W A;  2W5X A;  4N7T A;  2W5W A;  4KJD A;  2IUC B;  5KXA A;  1ANJ A;  1KH9 A;  1ALH A;  4GTZ A;  3TX0 A;  4UOO A;  1ZED A;  1AUK A;  1KH4 A;  4B56 A;  4FDJ A;  5DLV A;  3NKO A;  5EGE A;  3MK2 A;  5K4P A;  4NWJ A;  5EGH A;  3DYC A;  4LR9 A;  4ZG9 A;  1KHK A;  1ZEB A;  3BDF A;  3IGY B;  3Q3Q A;  1ALK A;  3NVL A;  3WAV A;  3UN5 A;  2G9Y A;  1B8J A;  1EI6 A;  2GA3 A;  1SHN A;  1ANI A;  2W5T A;  1URA A;  3IGZ B;  3A52 A;  1AJB A;  2GLQ A;  2IFY A;  3BDH A;  3SZY A;  3BDG B;  1ED9 A;  1E2S P;  4LRA A;  1O98 A;  1N2L A;  4KJG A;  4UOR A;  4ZG7 A;  1E33 P;  3M7V A;  1ELX A;  1N2K A;  2X98 A;  1AJA A;  5LRM A;  4LQY A;  4LR8 A;  4ZG6 A;  4LRB A;  4KAV A;  5LIA A;  1KHN A;  3M8Z A;  2QZU A;  3UN3 A;  3KD8 A;  4CXK A;  4KM4 A;  5IJS A;  5LQQ A;  1KHJ A;  4QAX A;  3TWZ A;  1EW9 A;  1Y7A A;  2IUC A;  3WBH A;  4ZGA A;  1ELZ A;  1EW8 A;  1AJD A;  4MIV A;  3WAY A;  1ALI A;  4UOP A;  4MHX A;  3OT9 A;  1KH7 A;  3NKM A;  4GTW A;  4LRF A;  5DLW A;  3MK1 A;  4UPL A;  1EJJ A;  3NKR A;  4LRD A;  2W5V A;  1EQJ A;  4FDI A;  1HDH A;  2ZKT A;  4MY4 A;  1P49 A;  5AJ9 A;  2W8S A;  2GSU A;  5IJQ A;  2XR9 A;  5L0E A;  1ZEF A;  4CXU A;  4CYS A;  5TJ3 A;  2W5S A;  4UPH A;  5GOV A;  2W5Q A;  3T00 A;  4LRE A;  3SZZ A;  3UN2 A;  3NKQ A;  3LXQ A;  3MK0 A;  1HJK A;  1EW2 A;  2D1G A;  4GTY A;  4YR1 A;  3TG0 A;  4LR2 A;  2RH6 A;  3WAW A;  3NKP A;  1FSU A;  4CXS A;  1KHL A;  1K7H A;  4GTX A;  1HQA A;  1E3C P;  2W5R A;  3IDD A;  5C66 A;  5HRT A;  1SHQ A;  5DLT A;  1Y6V A;  3DPC A;  4LR7 A;  4KAY A;  2W8D A;  4LRC A;  3ED4 A;  3WAX A;  2VQR A;  3UNY A;  4TN0 A;  5L0K A;  3E2D A;  3NKN A;  1ED8 A;  3B5Q A;  3M8Y A;  1URB A;  4UPI A;  1O99 A;  3UO0 A;  2XRG A;  3CMR A;  1ALJ A;  1E1Z P;  3BDG A;  5L0B A;  4CYR A;  4NWX A;  4UPK A;  2GSO A;  1ELY A;  2GSN A;  5INH A;  3T02 A;  5GRR A;  3T01 A;  5LRN A;  1AJC A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...