1URAA

Alkaline phosphatase (d51zn)
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGNGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Kinetic and structural consequences of replacing the aspartate bridge by asparagine in the catalytic metal triad of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 160
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1996-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1uraA00
5EGHA 3IDDA 1KH9A 1ANJA 2X98A 3M8ZA 4LR9A 3WAWA 3WAYA 3MK0A 1EW8A 1KHLA 4CXUA 4GTZA 5GOVA 4ZG9A 1ELXA 2W5XA 4FDJA 1HDHA 1KH4A 1KHNA 1O99A 1Y7AA 3T00A 4GTXA 5TJ3A 1EW2A 5LQQA 3TWZA 4UORA 4LQYA 1ANIA 1ALJA 4CXKA 4LR8A 3NKPA 4ZG7A 2GSOA 2ANHA 3BDGA 3UNYA 3DYCA 4LR2A 4LRDA 1P49A 2W5TA 2D1GA 5LIAA 3T01A 2VQRA 1KHKA 4YR1A 3TG0A 2QZUA 3IGYB 4UPLA 2IUCA 3A52A 2W8SA 1E1ZP 2W5SA 2W5RA 1AUKA 1AJBA 3B5QA 4NWXA 5L0KA 1B8JA 1EI6A 3NKNA 1ALHA 2W8DA 3TX0A 4CXSA 1AJDA 4LRAA 1SHQA 1ELZA 1FSUA 2W5QA 3NKOA 3MK1A 1K7HA 1Y6VA 4MHXA 1KH5A 1ZEFA 3WAVA 5K4PA 3DPCA 3UN3A 3SZYA 3MK2A 3KD8A 3OT9A 3WAXA 1HQAA 4ZGAA 2XRGA 3BDHA 3NKMA 4B56A 2W5VA 1EJJA 4LREA 3Q3QA 3T02A 1AJCA 2GA3A 4MIVA 4TN0A 5L0EA 4N7TA 5HRTA 1ZEBA 3BDGB 1EQJA 4LRBA 4UPIA 4KAVA 4KM4A 4UPHA 5DLWA 1HJKA 4KAYA 1ALKA 1E2SP 3SZZA 4CYRA 2GLQA 5L0BA 3ED4A 3NKRA 4ZG6A 3M8YA 4GTYA 2G9YA 1ED9A 1AJAA 3M7VA 4KJDA 4CYSA 3UN5A 3M8WA 5EGEA 1ZEDA 3E2DA 4GTWA 4UPKA 2ZKTA 1ELYA 3NKQA 1E3CP 2GSUA 3CMRA 2W5WA 1N2KA 4LR7A 1E33P 3UO0A 2IFYA 3BDFA 4FDIA 4UOOA 1N2LA 1SHNA 4LRFA 1KHJA 2XR9A 1URAA 3UN2A 5DLTA 5INHA 5IJQA 5IJSA 4QAXA 1KH7A 5C66A 1URBA 3LXQA 5LRNA 5KXAA 4MY4A 2RH6A 1ALIA 2IUCB 1EW9A 3NVLA 1O98A 1ED8A 5GRRA 3IGZB 4LRCA 4KJGA 2GSNA 4NWJA 3WBHA 5AJ9A 5DLVA 5LRMA 4UOPA
chains in the Genus database with same CATH superfamily
5EGHA 3IDDA 1KH9A 1ANJA 2X98A 3M8ZA 4LR9A 3WAWA 3WAYA 3MK0A 1EW8A 1KHLA 4CXUA 4GTZA 5GOVA 4ZG9A 1ELXA 2W5XA 4FDJA 1HDHA 1KH4A 1KHNA 1O99A 1Y7AA 3T00A 4GTXA 5TJ3A 1EW2A 5LQQA 3TWZA 4UORA 4LQYA 1ANIA 1ALJA 4CXKA 4LR8A 3NKPA 4ZG7A 2GSOA 2ANHA 3BDGA 3UNYA 3DYCA 4LR2A 4LRDA 1P49A 2W5TA 2D1GA 5LIAA 3T01A 2VQRA 1KHKA 4YR1A 3TG0A 2QZUA 3IGYB 4UPLA 2IUCA 3A52A 2W8SA 1E1ZP 2W5SA 2W5RA 1AUKA 1AJBA 3B5QA 4NWXA 5L0KA 1B8JA 1EI6A 3NKNA 1ALHA 2W8DA 3TX0A 4CXSA 1AJDA 4LRAA 1SHQA 1ELZA 1FSUA 2W5QA 3NKOA 3MK1A 1K7HA 1Y6VA 4MHXA 1KH5A 1ZEFA 3WAVA 5K4PA 3DPCA 3UN3A 3SZYA 3MK2A 3KD8A 3OT9A 3WAXA 1HQAA 4ZGAA 2XRGA 3BDHA 3NKMA 4B56A 2W5VA 1EJJA 4LREA 3Q3QA 3T02A 1AJCA 2GA3A 4MIVA 4TN0A 5L0EA 4N7TA 5HRTA 1ZEBA 3BDGB 1EQJA 4LRBA 4UPIA 4KAVA 4KM4A 4UPHA 5DLWA 1HJKA 4KAYA 1ALKA 1E2SP 3SZZA 4CYRA 2GLQA 5L0BA 3ED4A 3NKRA 4ZG6A 3M8YA 4GTYA 2G9YA 1ED9A 1AJAA 3M7VA 4KJDA 4CYSA 3UN5A 3M8WA 5EGEA 1ZEDA 3E2DA 4GTWA 4UPKA 2ZKTA 1ELYA 3NKQA 1E3CP 2GSUA 3CMRA 2W5WA 1N2KA 4LR7A 1E33P 3UO0A 2IFYA 3BDFA 4FDIA 4UOOA 1N2LA 1SHNA 4LRFA 1KHJA 2XR9A 1URAA 3UN2A 5DLTA 5INHA 5IJQA 5IJSA 4QAXA 1KH7A 5C66A 1URBA 3LXQA 5LRNA 5KXAA 4MY4A 2RH6A 1ALIA 2IUCB 1EW9A 3NVLA 1O98A 1ED8A 5GRRA 3IGZB 4LRCA 4KJGA 2GSNA 4NWJA 3WBHA 5AJ9A 5DLVA 5LRMA 4UOPA
chains in the Genus database with same CATH topology
5EGHA 3IDDA 1KH9A 1ANJA 2X98A 3M8ZA 4LR9A 3WAWA 3WAYA 3MK0A 1EW8A 1KHLA 4CXUA 4GTZA 5GOVA 4ZG9A 1ELXA 2W5XA 4FDJA 1HDHA 1KH4A 1KHNA 1O99A 1Y7AA 3T00A 4GTXA 5TJ3A 1EW2A 5LQQA 3TWZA 4UORA 4LQYA 1ANIA 1ALJA 4CXKA 4LR8A 3NKPA 4ZG7A 2GSOA 2ANHA 3BDGA 3UNYA 3DYCA 4LR2A 4LRDA 1P49A 2W5TA 2D1GA 5LIAA 3T01A 2VQRA 1KHKA 4YR1A 3TG0A 2QZUA 3IGYB 4UPLA 2IUCA 3A52A 2W8SA 1E1ZP 2W5SA 2W5RA 1AUKA 1AJBA 3B5QA 4NWXA 5L0KA 1B8JA 1EI6A 3NKNA 1ALHA 2W8DA 3TX0A 4CXSA 1AJDA 4LRAA 1SHQA 1ELZA 1FSUA 2W5QA 3NKOA 3MK1A 1K7HA 1Y6VA 4MHXA 1KH5A 1ZEFA 3WAVA 5K4PA 3DPCA 3UN3A 3SZYA 3MK2A 3KD8A 3OT9A 3WAXA 1HQAA 4ZGAA 2XRGA 3BDHA 3NKMA 4B56A 2W5VA 1EJJA 4LREA 3Q3QA 3T02A 1AJCA 2GA3A 4MIVA 4TN0A 5L0EA 4N7TA 5HRTA 1ZEBA 3BDGB 1EQJA 4LRBA 4UPIA 4KAVA 4KM4A 4UPHA 5DLWA 1HJKA 4KAYA 1ALKA 1E2SP 3SZZA 4CYRA 2GLQA 5L0BA 3ED4A 3NKRA 4ZG6A 3M8YA 4GTYA 2G9YA 1ED9A 1AJAA 3M7VA 4KJDA 4CYSA 3UN5A 3M8WA 5EGEA 1ZEDA 3E2DA 4GTWA 4UPKA 2ZKTA 1ELYA 3NKQA 1E3CP 2GSUA 3CMRA 2W5WA 1N2KA 4LR7A 1E33P 3UO0A 2IFYA 3BDFA 4FDIA 4UOOA 1N2LA 1SHNA 4LRFA 1KHJA 2XR9A 1URAA 3UN2A 5DLTA 5INHA 5IJQA 5IJSA 4QAXA 1KH7A 5C66A 1URBA 3LXQA 5LRNA 5KXAA 4MY4A 2RH6A 1ALIA 2IUCB 1EW9A 3NVLA 1O98A 1ED8A 5GRRA 3IGZB 4LRCA 4KJGA 2GSNA 4NWJA 3WBHA 5AJ9A 5DLVA 5LRMA 4UOPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EGH A;  3IDD A;  1KH9 A;  1ANJ A;  2X98 A;  3M8Z A;  4LR9 A;  3WAW A;  3WAY A;  3MK0 A;  1EW8 A;  1KHL A;  4CXU A;  4GTZ A;  5GOV A;  4ZG9 A;  1ELX A;  2W5X A;  4FDJ A;  1HDH A;  1KH4 A;  1KHN A;  1O99 A;  1Y7A A;  3T00 A;  4GTX A;  5TJ3 A;  1EW2 A;  5LQQ A;  3TWZ A;  4UOR A;  4LQY A;  1ANI A;  1ALJ A;  4CXK A;  4LR8 A;  3NKP A;  4ZG7 A;  2GSO A;  2ANH A;  3BDG A;  3UNY A;  3DYC A;  4LR2 A;  4LRD A;  1P49 A;  2W5T A;  2D1G A;  5LIA A;  3T01 A;  2VQR A;  1KHK A;  4YR1 A;  3TG0 A;  2QZU A;  3IGY B;  4UPL A;  2IUC A;  3A52 A;  2W8S A;  1E1Z P;  2W5S A;  2W5R A;  1AUK A;  1AJB A;  3B5Q A;  4NWX A;  5L0K A;  1B8J A;  1EI6 A;  3NKN A;  1ALH A;  2W8D A;  3TX0 A;  4CXS A;  1AJD A;  4LRA A;  1SHQ A;  1ELZ A;  1FSU A;  2W5Q A;  3NKO A;  3MK1 A;  1K7H A;  1Y6V A;  4MHX A;  1KH5 A;  1ZEF A;  3WAV A;  5K4P A;  3DPC A;  3UN3 A;  3SZY A;  3MK2 A;  3KD8 A;  3OT9 A;  3WAX A;  1HQA A;  4ZGA A;  2XRG A;  3BDH A;  3NKM A;  4B56 A;  2W5V A;  1EJJ A;  4LRE A;  3Q3Q A;  3T02 A;  1AJC A;  2GA3 A;  4MIV A;  4TN0 A;  5L0E A;  4N7T A;  5HRT A;  1ZEB A;  3BDG B;  1EQJ A;  4LRB A;  4UPI A;  4KAV A;  4KM4 A;  4UPH A;  5DLW A;  1HJK A;  4KAY A;  1ALK A;  1E2S P;  3SZZ A;  4CYR A;  2GLQ A;  5L0B A;  3ED4 A;  3NKR A;  4ZG6 A;  3M8Y A;  4GTY A;  2G9Y A;  1ED9 A;  1AJA A;  3M7V A;  4KJD A;  4CYS A;  3UN5 A;  3M8W A;  5EGE A;  1ZED A;  3E2D A;  4GTW A;  4UPK A;  2ZKT A;  1ELY A;  3NKQ A;  1E3C P;  2GSU A;  3CMR A;  2W5W A;  1N2K A;  4LR7 A;  1E33 P;  3UO0 A;  2IFY A;  3BDF A;  4FDI A;  4UOO A;  1N2L A;  1SHN A;  4LRF A;  1KHJ A;  2XR9 A;  1URA A;  3UN2 A;  5DLT A;  5INH A;  5IJQ A;  5IJS A;  4QAX A;  1KH7 A;  5C66 A;  1URB A;  3LXQ A;  5LRN A;  5KXA A;  4MY4 A;  2RH6 A;  1ALI A;  2IUC B;  1EW9 A;  3NVL A;  1O98 A;  1ED8 A;  5GRR A;  3IGZ B;  4LRC A;  4KJG A;  2GSN A;  4NWJ A;  3WBH A;  5AJ9 A;  5DLV A;  5LRM A;  4UOP A; 
#chains in the Genus database with same CATH topology
 5EGH A;  3IDD A;  1KH9 A;  1ANJ A;  2X98 A;  3M8Z A;  4LR9 A;  3WAW A;  3WAY A;  3MK0 A;  1EW8 A;  1KHL A;  4CXU A;  4GTZ A;  5GOV A;  4ZG9 A;  1ELX A;  2W5X A;  4FDJ A;  1HDH A;  1KH4 A;  1KHN A;  1O99 A;  1Y7A A;  3T00 A;  4GTX A;  5TJ3 A;  1EW2 A;  5LQQ A;  3TWZ A;  4UOR A;  4LQY A;  1ANI A;  1ALJ A;  4CXK A;  4LR8 A;  3NKP A;  4ZG7 A;  2GSO A;  2ANH A;  3BDG A;  3UNY A;  3DYC A;  4LR2 A;  4LRD A;  1P49 A;  2W5T A;  2D1G A;  5LIA A;  3T01 A;  2VQR A;  1KHK A;  4YR1 A;  3TG0 A;  2QZU A;  3IGY B;  4UPL A;  2IUC A;  3A52 A;  2W8S A;  1E1Z P;  2W5S A;  2W5R A;  1AUK A;  1AJB A;  3B5Q A;  4NWX A;  5L0K A;  1B8J A;  1EI6 A;  3NKN A;  1ALH A;  2W8D A;  3TX0 A;  4CXS A;  1AJD A;  4LRA A;  1SHQ A;  1ELZ A;  1FSU A;  2W5Q A;  3NKO A;  3MK1 A;  1K7H A;  1Y6V A;  4MHX A;  1KH5 A;  1ZEF A;  3WAV A;  5K4P A;  3DPC A;  3UN3 A;  3SZY A;  3MK2 A;  3KD8 A;  3OT9 A;  3WAX A;  1HQA A;  4ZGA A;  2XRG A;  3BDH A;  3NKM A;  4B56 A;  2W5V A;  1EJJ A;  4LRE A;  3Q3Q A;  3T02 A;  1AJC A;  2GA3 A;  4MIV A;  4TN0 A;  5L0E A;  4N7T A;  5HRT A;  1ZEB A;  3BDG B;  1EQJ A;  4LRB A;  4UPI A;  4KAV A;  4KM4 A;  4UPH A;  5DLW A;  1HJK A;  4KAY A;  1ALK A;  1E2S P;  3SZZ A;  4CYR A;  2GLQ A;  5L0B A;  3ED4 A;  3NKR A;  4ZG6 A;  3M8Y A;  4GTY A;  2G9Y A;  1ED9 A;  1AJA A;  3M7V A;  4KJD A;  4CYS A;  3UN5 A;  3M8W A;  5EGE A;  1ZED A;  3E2D A;  4GTW A;  4UPK A;  2ZKT A;  1ELY A;  3NKQ A;  1E3C P;  2GSU A;  3CMR A;  2W5W A;  1N2K A;  4LR7 A;  1E33 P;  3UO0 A;  2IFY A;  3BDF A;  4FDI A;  4UOO A;  1N2L A;  1SHN A;  4LRF A;  1KHJ A;  2XR9 A;  1URA A;  3UN2 A;  5DLT A;  5INH A;  5IJQ A;  5IJS A;  4QAX A;  1KH7 A;  5C66 A;  1URB A;  3LXQ A;  5LRN A;  5KXA A;  4MY4 A;  2RH6 A;  1ALI A;  2IUC B;  1EW9 A;  3NVL A;  1O98 A;  1ED8 A;  5GRR A;  3IGZ B;  4LRC A;  4KJG A;  2GSN A;  4NWJ A;  3WBH A;  5AJ9 A;  5DLV A;  5LRM A;  4UOP A; 
#chains in the Genus database with same CATH homology
 5EGH A;  3IDD A;  1KH9 A;  1ANJ A;  2X98 A;  3M8Z A;  4LR9 A;  3WAW A;  3WAY A;  3MK0 A;  1EW8 A;  1KHL A;  4CXU A;  4GTZ A;  5GOV A;  4ZG9 A;  1ELX A;  2W5X A;  4FDJ A;  1HDH A;  1KH4 A;  1KHN A;  1O99 A;  1Y7A A;  3T00 A;  4GTX A;  5TJ3 A;  1EW2 A;  5LQQ A;  3TWZ A;  4UOR A;  4LQY A;  1ANI A;  1ALJ A;  4CXK A;  4LR8 A;  3NKP A;  4ZG7 A;  2GSO A;  2ANH A;  3BDG A;  3UNY A;  3DYC A;  4LR2 A;  4LRD A;  1P49 A;  2W5T A;  2D1G A;  5LIA A;  3T01 A;  2VQR A;  1KHK A;  4YR1 A;  3TG0 A;  2QZU A;  3IGY B;  4UPL A;  2IUC A;  3A52 A;  2W8S A;  1E1Z P;  2W5S A;  2W5R A;  1AUK A;  1AJB A;  3B5Q A;  4NWX A;  5L0K A;  1B8J A;  1EI6 A;  3NKN A;  1ALH A;  2W8D A;  3TX0 A;  4CXS A;  1AJD A;  4LRA A;  1SHQ A;  1ELZ A;  1FSU A;  2W5Q A;  3NKO A;  3MK1 A;  1K7H A;  1Y6V A;  4MHX A;  1KH5 A;  1ZEF A;  3WAV A;  5K4P A;  3DPC A;  3UN3 A;  3SZY A;  3MK2 A;  3KD8 A;  3OT9 A;  3WAX A;  1HQA A;  4ZGA A;  2XRG A;  3BDH A;  3NKM A;  4B56 A;  2W5V A;  1EJJ A;  4LRE A;  3Q3Q A;  3T02 A;  1AJC A;  2GA3 A;  4MIV A;  4TN0 A;  5L0E A;  4N7T A;  5HRT A;  1ZEB A;  3BDG B;  1EQJ A;  4LRB A;  4UPI A;  4KAV A;  4KM4 A;  4UPH A;  5DLW A;  1HJK A;  4KAY A;  1ALK A;  1E2S P;  3SZZ A;  4CYR A;  2GLQ A;  5L0B A;  3ED4 A;  3NKR A;  4ZG6 A;  3M8Y A;  4GTY A;  2G9Y A;  1ED9 A;  1AJA A;  3M7V A;  4KJD A;  4CYS A;  3UN5 A;  3M8W A;  5EGE A;  1ZED A;  3E2D A;  4GTW A;  4UPK A;  2ZKT A;  1ELY A;  3NKQ A;  1E3C P;  2GSU A;  3CMR A;  2W5W A;  1N2K A;  4LR7 A;  1E33 P;  3UO0 A;  2IFY A;  3BDF A;  4FDI A;  4UOO A;  1N2L A;  1SHN A;  4LRF A;  1KHJ A;  2XR9 A;  1URA A;  3UN2 A;  5DLT A;  5INH A;  5IJQ A;  5IJS A;  4QAX A;  1KH7 A;  5C66 A;  1URB A;  3LXQ A;  5LRN A;  5KXA A;  4MY4 A;  2RH6 A;  1ALI A;  2IUC B;  1EW9 A;  3NVL A;  1O98 A;  1ED8 A;  5GRR A;  3IGZ B;  4LRC A;  4KJG A;  2GSN A;  4NWJ A;  3WBH A;  5AJ9 A;  5DLV A;  5LRM A;  4UOP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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