1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Alkaline phosphatase
publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
2GA3A 3UN3A 1ELYA 4TN0A 5LIAA 2GSNA 2ZKTA 1KHKA 1EQJA 1EI6A 4KJDA 1ZEBA 5HRTA 4CYSA 3WAXA 3M8ZA 1ANIA 2X98A 2W5XA 3NKPA 4NWXA 1ELZA 4GTXA 1AJCA 1ZEFA 2GSOA 3A52A 2XRGA 4UPKA 3NKNA 1FSUA 5L0EA 4LREA 4ZG9A 4N7TA 1ALJA 3NVLA 1ANJA 2W5TA 2XR9A 4ZGAA 2RH6A 1ZEDA 1EW8A 3SZZA 4B56A 4MIVA 3NKQA 3BDGB 5AJ9A 3WAYA 4GTZA 1EJJA 1AJAA 5EGEA 1AUKA 1KH5A 3T01A 3CMRA 1B8JA 4KJGA 4CYRA 1N2KA 5LRMA 1KHJA 5IJQA 3T00A 4CXKA 3DYCA 1ED9A 4MY4A 5GRRA 4KAYA 4UOPA 4KM4A 2IUCA 5C66A 5KXAA 3TWZA 1HQAA 1N2LA 4UOOA 2GLQA 1E1ZP 1E33P 4FDJA 1ED8A 1HDHA 4LQYA 4NWJA 3KD8A 5DLWA 5GOVA 5DLTA 3TG0A 5LQQA 2ANHA 4GTYA 4UPHA 3WBHA 2G9YA 3UNYA 3Q3QA 5LRNA 1E3CP 5L0KA 1HJKA 3TX0A 2VQRA 3M8WA 4UPLA 4MHXA 1EW9A 3BDHA 5EGHA 1URAA 3NKMA 2W5WA 3LXQA 4LRCA 4YR1A 4LR9A 2IFYA 3IDDA 3UN2A 3M7VA 5IJSA 1KHLA 4ZG7A 3MK1A 4FDIA 3E2DA 2D1GA 5DLVA 1Y6VA 3DPCA 1K7HA 3IGYB 3UO0A 1KH4A 4LR8A 5TJ3A 1EW2A 2QZUA 3ED4A 4LR2A 5K4PA 4GTWA 1P49A 4UPIA 1AJDA 2W5SA 1ELXA 1O99A 1SHNA 2W8SA 3OT9A 4LRDA 3WAVA 1SHQA 4LRBA 1KH7A 2W5VA 3IGZB 1Y7AA 4LRFA 2W5RA 3UN5A 1ALIA 3BDGA 4CXSA 4UORA 2IUCB 4LR7A 5INHA 2W5QA 4QAXA 3B5QA 4KAVA 3WAWA 1ALKA 1KHNA 2GSUA 3BDFA 3NKOA 3NKRA 2W8DA 4ZG6A 4CXUA 1AJBA 3SZYA 4LRAA 1URBA 1O98A 1E2SP 3MK0A 5L0BA 1ALHA 3T02A 3MK2A 1KH9A 3M8YA
chains in the Genus database with same CATH superfamily
2GA3A 3UN3A 1ELYA 4TN0A 5LIAA 2GSNA 2ZKTA 1KHKA 1EQJA 1EI6A 4KJDA 1ZEBA 5HRTA 4CYSA 3WAXA 3M8ZA 1ANIA 2X98A 2W5XA 3NKPA 4NWXA 1ELZA 4GTXA 1AJCA 1ZEFA 2GSOA 3A52A 2XRGA 4UPKA 3NKNA 1FSUA 5L0EA 4LREA 4ZG9A 4N7TA 1ALJA 3NVLA 1ANJA 2W5TA 2XR9A 4ZGAA 2RH6A 1ZEDA 1EW8A 3SZZA 4B56A 4MIVA 3NKQA 3BDGB 5AJ9A 3WAYA 4GTZA 1EJJA 1AJAA 5EGEA 1AUKA 1KH5A 3T01A 3CMRA 1B8JA 4KJGA 4CYRA 1N2KA 5LRMA 1KHJA 5IJQA 3T00A 4CXKA 3DYCA 1ED9A 4MY4A 5GRRA 4KAYA 4UOPA 4KM4A 2IUCA 5C66A 5KXAA 3TWZA 1HQAA 1N2LA 4UOOA 2GLQA 1E1ZP 1E33P 4FDJA 1ED8A 1HDHA 4LQYA 4NWJA 3KD8A 5DLWA 5GOVA 5DLTA 3TG0A 5LQQA 2ANHA 4GTYA 4UPHA 3WBHA 2G9YA 3UNYA 3Q3QA 5LRNA 1E3CP 5L0KA 1HJKA 3TX0A 2VQRA 3M8WA 4UPLA 4MHXA 1EW9A 3BDHA 5EGHA 1URAA 3NKMA 2W5WA 3LXQA 4LRCA 4YR1A 4LR9A 2IFYA 3IDDA 3UN2A 3M7VA 5IJSA 1KHLA 4ZG7A 3MK1A 4FDIA 3E2DA 2D1GA 5DLVA 1Y6VA 3DPCA 1K7HA 3IGYB 3UO0A 1KH4A 4LR8A 5TJ3A 1EW2A 2QZUA 3ED4A 4LR2A 5K4PA 4GTWA 1P49A 4UPIA 1AJDA 2W5SA 1ELXA 1O99A 1SHNA 2W8SA 3OT9A 4LRDA 3WAVA 1SHQA 4LRBA 1KH7A 2W5VA 3IGZB 1Y7AA 4LRFA 2W5RA 3UN5A 1ALIA 3BDGA 4CXSA 4UORA 2IUCB 4LR7A 5INHA 2W5QA 4QAXA 3B5QA 4KAVA 3WAWA 1ALKA 1KHNA 2GSUA 3BDFA 3NKOA 3NKRA 2W8DA 4ZG6A 4CXUA 1AJBA 3SZYA 4LRAA 1URBA 1O98A 1E2SP 3MK0A 5L0BA 1ALHA 3T02A 3MK2A 1KH9A 3M8YA
chains in the Genus database with same CATH topology
2GA3A 3UN3A 1ELYA 4TN0A 5LIAA 2GSNA 2ZKTA 1KHKA 1EQJA 1EI6A 4KJDA 1ZEBA 5HRTA 4CYSA 3WAXA 3M8ZA 1ANIA 2X98A 2W5XA 3NKPA 4NWXA 1ELZA 4GTXA 1AJCA 1ZEFA 2GSOA 3A52A 2XRGA 4UPKA 3NKNA 1FSUA 5L0EA 4LREA 4ZG9A 4N7TA 1ALJA 3NVLA 1ANJA 2W5TA 2XR9A 4ZGAA 2RH6A 1ZEDA 1EW8A 3SZZA 4B56A 4MIVA 3NKQA 3BDGB 5AJ9A 3WAYA 4GTZA 1EJJA 1AJAA 5EGEA 1AUKA 1KH5A 3T01A 3CMRA 1B8JA 4KJGA 4CYRA 1N2KA 5LRMA 1KHJA 5IJQA 3T00A 4CXKA 3DYCA 1ED9A 4MY4A 5GRRA 4KAYA 4UOPA 4KM4A 2IUCA 5C66A 5KXAA 3TWZA 1HQAA 1N2LA 4UOOA 2GLQA 1E1ZP 1E33P 4FDJA 1ED8A 1HDHA 4LQYA 4NWJA 3KD8A 5DLWA 5GOVA 5DLTA 3TG0A 5LQQA 2ANHA 4GTYA 4UPHA 3WBHA 2G9YA 3UNYA 3Q3QA 5LRNA 1E3CP 5L0KA 1HJKA 3TX0A 2VQRA 3M8WA 4UPLA 4MHXA 1EW9A 3BDHA 5EGHA 1URAA 3NKMA 2W5WA 3LXQA 4LRCA 4YR1A 4LR9A 2IFYA 3IDDA 3UN2A 3M7VA 5IJSA 1KHLA 4ZG7A 3MK1A 4FDIA 3E2DA 2D1GA 5DLVA 1Y6VA 3DPCA 1K7HA 3IGYB 3UO0A 1KH4A 4LR8A 5TJ3A 1EW2A 2QZUA 3ED4A 4LR2A 5K4PA 4GTWA 1P49A 4UPIA 1AJDA 2W5SA 1ELXA 1O99A 1SHNA 2W8SA 3OT9A 4LRDA 3WAVA 1SHQA 4LRBA 1KH7A 2W5VA 3IGZB 1Y7AA 4LRFA 2W5RA 3UN5A 1ALIA 3BDGA 4CXSA 4UORA 2IUCB 4LR7A 5INHA 2W5QA 4QAXA 3B5QA 4KAVA 3WAWA 1ALKA 1KHNA 2GSUA 3BDFA 3NKOA 3NKRA 2W8DA 4ZG6A 4CXUA 1AJBA 3SZYA 4LRAA 1URBA 1O98A 1E2SP 3MK0A 5L0BA 1ALHA 3T02A 3MK2A 1KH9A 3M8YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GA3 A;  3UN3 A;  1ELY A;  4TN0 A;  5LIA A;  2GSN A;  2ZKT A;  1KHK A;  1EQJ A;  1EI6 A;  4KJD A;  1ZEB A;  5HRT A;  4CYS A;  3WAX A;  3M8Z A;  1ANI A;  2X98 A;  2W5X A;  3NKP A;  4NWX A;  1ELZ A;  4GTX A;  1AJC A;  1ZEF A;  2GSO A;  3A52 A;  2XRG A;  4UPK A;  3NKN A;  1FSU A;  5L0E A;  4LRE A;  4ZG9 A;  4N7T A;  1ALJ A;  3NVL A;  1ANJ A;  2W5T A;  2XR9 A;  4ZGA A;  2RH6 A;  1ZED A;  1EW8 A;  3SZZ A;  4B56 A;  4MIV A;  3NKQ A;  3BDG B;  5AJ9 A;  3WAY A;  4GTZ A;  1EJJ A;  1AJA A;  5EGE A;  1AUK A;  1KH5 A;  3T01 A;  3CMR A;  1B8J A;  4KJG A;  4CYR A;  1N2K A;  5LRM A;  1KHJ A;  5IJQ A;  3T00 A;  4CXK A;  3DYC A;  1ED9 A;  4MY4 A;  5GRR A;  4KAY A;  4UOP A;  4KM4 A;  2IUC A;  5C66 A;  5KXA A;  3TWZ A;  1HQA A;  1N2L A;  4UOO A;  2GLQ A;  1E1Z P;  1E33 P;  4FDJ A;  1ED8 A;  1HDH A;  4LQY A;  4NWJ A;  3KD8 A;  5DLW A;  5GOV A;  5DLT A;  3TG0 A;  5LQQ A;  2ANH A;  4GTY A;  4UPH A;  3WBH A;  2G9Y A;  3UNY A;  3Q3Q A;  5LRN A;  1E3C P;  5L0K A;  1HJK A;  3TX0 A;  2VQR A;  3M8W A;  4UPL A;  4MHX A;  1EW9 A;  3BDH A;  5EGH A;  1URA A;  3NKM A;  2W5W A;  3LXQ A;  4LRC A;  4YR1 A;  4LR9 A;  2IFY A;  3IDD A;  3UN2 A;  3M7V A;  5IJS A;  1KHL A;  4ZG7 A;  3MK1 A;  4FDI A;  3E2D A;  2D1G A;  5DLV A;  1Y6V A;  3DPC A;  1K7H A;  3IGY B;  3UO0 A;  1KH4 A;  4LR8 A;  5TJ3 A;  1EW2 A;  2QZU A;  3ED4 A;  4LR2 A;  5K4P A;  4GTW A;  1P49 A;  4UPI A;  1AJD A;  2W5S A;  1ELX A;  1O99 A;  1SHN A;  2W8S A;  3OT9 A;  4LRD A;  3WAV A;  1SHQ A;  4LRB A;  1KH7 A;  2W5V A;  3IGZ B;  1Y7A A;  4LRF A;  2W5R A;  3UN5 A;  1ALI A;  3BDG A;  4CXS A;  4UOR A;  2IUC B;  4LR7 A;  5INH A;  2W5Q A;  4QAX A;  3B5Q A;  4KAV A;  3WAW A;  1ALK A;  1KHN A;  2GSU A;  3BDF A;  3NKO A;  3NKR A;  2W8D A;  4ZG6 A;  4CXU A;  1AJB A;  3SZY A;  4LRA A;  1URB A;  1O98 A;  1E2S P;  3MK0 A;  5L0B A;  1ALH A;  3T02 A;  3MK2 A;  1KH9 A;  3M8Y A; 
#chains in the Genus database with same CATH topology
 2GA3 A;  3UN3 A;  1ELY A;  4TN0 A;  5LIA A;  2GSN A;  2ZKT A;  1KHK A;  1EQJ A;  1EI6 A;  4KJD A;  1ZEB A;  5HRT A;  4CYS A;  3WAX A;  3M8Z A;  1ANI A;  2X98 A;  2W5X A;  3NKP A;  4NWX A;  1ELZ A;  4GTX A;  1AJC A;  1ZEF A;  2GSO A;  3A52 A;  2XRG A;  4UPK A;  3NKN A;  1FSU A;  5L0E A;  4LRE A;  4ZG9 A;  4N7T A;  1ALJ A;  3NVL A;  1ANJ A;  2W5T A;  2XR9 A;  4ZGA A;  2RH6 A;  1ZED A;  1EW8 A;  3SZZ A;  4B56 A;  4MIV A;  3NKQ A;  3BDG B;  5AJ9 A;  3WAY A;  4GTZ A;  1EJJ A;  1AJA A;  5EGE A;  1AUK A;  1KH5 A;  3T01 A;  3CMR A;  1B8J A;  4KJG A;  4CYR A;  1N2K A;  5LRM A;  1KHJ A;  5IJQ A;  3T00 A;  4CXK A;  3DYC A;  1ED9 A;  4MY4 A;  5GRR A;  4KAY A;  4UOP A;  4KM4 A;  2IUC A;  5C66 A;  5KXA A;  3TWZ A;  1HQA A;  1N2L A;  4UOO A;  2GLQ A;  1E1Z P;  1E33 P;  4FDJ A;  1ED8 A;  1HDH A;  4LQY A;  4NWJ A;  3KD8 A;  5DLW A;  5GOV A;  5DLT A;  3TG0 A;  5LQQ A;  2ANH A;  4GTY A;  4UPH A;  3WBH A;  2G9Y A;  3UNY A;  3Q3Q A;  5LRN A;  1E3C P;  5L0K A;  1HJK A;  3TX0 A;  2VQR A;  3M8W A;  4UPL A;  4MHX A;  1EW9 A;  3BDH A;  5EGH A;  1URA A;  3NKM A;  2W5W A;  3LXQ A;  4LRC A;  4YR1 A;  4LR9 A;  2IFY A;  3IDD A;  3UN2 A;  3M7V A;  5IJS A;  1KHL A;  4ZG7 A;  3MK1 A;  4FDI A;  3E2D A;  2D1G A;  5DLV A;  1Y6V A;  3DPC A;  1K7H A;  3IGY B;  3UO0 A;  1KH4 A;  4LR8 A;  5TJ3 A;  1EW2 A;  2QZU A;  3ED4 A;  4LR2 A;  5K4P A;  4GTW A;  1P49 A;  4UPI A;  1AJD A;  2W5S A;  1ELX A;  1O99 A;  1SHN A;  2W8S A;  3OT9 A;  4LRD A;  3WAV A;  1SHQ A;  4LRB A;  1KH7 A;  2W5V A;  3IGZ B;  1Y7A A;  4LRF A;  2W5R A;  3UN5 A;  1ALI A;  3BDG A;  4CXS A;  4UOR A;  2IUC B;  4LR7 A;  5INH A;  2W5Q A;  4QAX A;  3B5Q A;  4KAV A;  3WAW A;  1ALK A;  1KHN A;  2GSU A;  3BDF A;  3NKO A;  3NKR A;  2W8D A;  4ZG6 A;  4CXU A;  1AJB A;  3SZY A;  4LRA A;  1URB A;  1O98 A;  1E2S P;  3MK0 A;  5L0B A;  1ALH A;  3T02 A;  3MK2 A;  1KH9 A;  3M8Y A; 
#chains in the Genus database with same CATH homology
 2GA3 A;  3UN3 A;  1ELY A;  4TN0 A;  5LIA A;  2GSN A;  2ZKT A;  1KHK A;  1EQJ A;  1EI6 A;  4KJD A;  1ZEB A;  5HRT A;  4CYS A;  3WAX A;  3M8Z A;  1ANI A;  2X98 A;  2W5X A;  3NKP A;  4NWX A;  1ELZ A;  4GTX A;  1AJC A;  1ZEF A;  2GSO A;  3A52 A;  2XRG A;  4UPK A;  3NKN A;  1FSU A;  5L0E A;  4LRE A;  4ZG9 A;  4N7T A;  1ALJ A;  3NVL A;  1ANJ A;  2W5T A;  2XR9 A;  4ZGA A;  2RH6 A;  1ZED A;  1EW8 A;  3SZZ A;  4B56 A;  4MIV A;  3NKQ A;  3BDG B;  5AJ9 A;  3WAY A;  4GTZ A;  1EJJ A;  1AJA A;  5EGE A;  1AUK A;  1KH5 A;  3T01 A;  3CMR A;  1B8J A;  4KJG A;  4CYR A;  1N2K A;  5LRM A;  1KHJ A;  5IJQ A;  3T00 A;  4CXK A;  3DYC A;  1ED9 A;  4MY4 A;  5GRR A;  4KAY A;  4UOP A;  4KM4 A;  2IUC A;  5C66 A;  5KXA A;  3TWZ A;  1HQA A;  1N2L A;  4UOO A;  2GLQ A;  1E1Z P;  1E33 P;  4FDJ A;  1ED8 A;  1HDH A;  4LQY A;  4NWJ A;  3KD8 A;  5DLW A;  5GOV A;  5DLT A;  3TG0 A;  5LQQ A;  2ANH A;  4GTY A;  4UPH A;  3WBH A;  2G9Y A;  3UNY A;  3Q3Q A;  5LRN A;  1E3C P;  5L0K A;  1HJK A;  3TX0 A;  2VQR A;  3M8W A;  4UPL A;  4MHX A;  1EW9 A;  3BDH A;  5EGH A;  1URA A;  3NKM A;  2W5W A;  3LXQ A;  4LRC A;  4YR1 A;  4LR9 A;  2IFY A;  3IDD A;  3UN2 A;  3M7V A;  5IJS A;  1KHL A;  4ZG7 A;  3MK1 A;  4FDI A;  3E2D A;  2D1G A;  5DLV A;  1Y6V A;  3DPC A;  1K7H A;  3IGY B;  3UO0 A;  1KH4 A;  4LR8 A;  5TJ3 A;  1EW2 A;  2QZU A;  3ED4 A;  4LR2 A;  5K4P A;  4GTW A;  1P49 A;  4UPI A;  1AJD A;  2W5S A;  1ELX A;  1O99 A;  1SHN A;  2W8S A;  3OT9 A;  4LRD A;  3WAV A;  1SHQ A;  4LRB A;  1KH7 A;  2W5V A;  3IGZ B;  1Y7A A;  4LRF A;  2W5R A;  3UN5 A;  1ALI A;  3BDG A;  4CXS A;  4UOR A;  2IUC B;  4LR7 A;  5INH A;  2W5Q A;  4QAX A;  3B5Q A;  4KAV A;  3WAW A;  1ALK A;  1KHN A;  2GSU A;  3BDF A;  3NKO A;  3NKR A;  2W8D A;  4ZG6 A;  4CXU A;  1AJB A;  3SZY A;  4LRA A;  1URB A;  1O98 A;  1E2S P;  3MK0 A;  5L0B A;  1ALH A;  3T02 A;  3MK2 A;  1KH9 A;  3M8Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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