1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Alkaline phosphatase
publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
source organism Escherichia coli
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
4GTZA 4LRFA 4NWXA 5KXAA 3LXQA 3UN5A 5IJQA 1KHLA 1E1ZP 4UOPA 3DPCA 1ANJA 3KD8A 2W5RA 1K7HA 4KJGA 1E33P 3MK2A 3T02A 2VQRA 1KH4A 4LRDA 5LIAA 3E2DA 1HQAA 5GOVA 1EW8A 4LRCA 3M8YA 4FDIA 1ALJA 3T00A 4CYSA 1AJDA 3TG0A 4GTWA 4UOOA 3TWZA 4GTYA 2RH6A 5L0EA 4LREA 2XR9A 4GTXA 4ZG6A 1ALKA 1URAA 3IDDA 3UN2A 4TN0A 1EI6A 4NWJA 1ELXA 3NKNA 4ZGAA 2IFYA 1EQJA 4CXKA 4KAVA 2GLQA 5DLTA 3TX0A 2GSNA 3WBHA 1EJJA 3IGZB 3NKQA 2XRGA 1ANIA 1N2LA 3NKRA 1AJBA 5LQQA 1KH9A 2GA3A 4KJDA 5L0BA 1URBA 1Y7AA 2W5SA 4LRBA 4ZG7A 4ZG9A 1FSUA 1Y6VA 3NKOA 3OT9A 2GSUA 2W5VA 3IGYB 3NKMA 3BDGA 3M8WA 1ED9A 1KHKA 2W8DA 5TJ3A 2IUCA 4FDJA 4LR9A 3M8ZA 1E2SP 4MHXA 1ALHA 3M7VA 2W5WA 4CXSA 2GSOA 4LR7A 5DLWA 1O99A 4MY4A 3UN3A 2ANHA 1ED8A 4CXUA 3BDFA 3SZYA 3MK1A 4UPHA 4CYRA 3CMRA 3MK0A 3WAXA 2W5XA 1KH5A 1ALIA 1HJKA 2W8SA 3DYCA 4QAXA 1KHNA 4LR2A 2W5QA 3WAYA 5C66A 4MIVA 5GRRA 5LRNA 1AJCA 3B5QA 5EGHA 4KAYA 1AJAA 1EW2A 1KHJA 5IJSA 4KM4A 1HDHA 3WAWA 2QZUA 1P49A 4B56A 2ZKTA 3UNYA 5HRTA 3NVLA 4UPIA 4UPLA 1AUKA 5L0KA 5K4PA 3BDGB 4N7TA 5INHA 3A52A 2IUCB 4LQYA 4LRAA 1ZEBA 4UPKA 1O98A 4YR1A 1ELZA 5DLVA 1ZEFA 3BDHA 3ED4A 3Q3QA 3WAVA 1EW9A 1SHQA 1SHNA 2G9YA 4LR8A 3UO0A 5EGEA 2W5TA 3NKPA 1N2KA 2D1GA 1E3CP 1KH7A 1ELYA 4UORA 5AJ9A 2X98A 1ZEDA 3T01A 1B8JA 3SZZA 5LRMA
chains in the Genus database with same CATH superfamily
4GTZA 4LRFA 4NWXA 5KXAA 3LXQA 3UN5A 5IJQA 1KHLA 1E1ZP 4UOPA 3DPCA 1ANJA 3KD8A 2W5RA 1K7HA 4KJGA 1E33P 3MK2A 3T02A 2VQRA 1KH4A 4LRDA 5LIAA 3E2DA 1HQAA 5GOVA 1EW8A 4LRCA 3M8YA 4FDIA 1ALJA 3T00A 4CYSA 1AJDA 3TG0A 4GTWA 4UOOA 3TWZA 4GTYA 2RH6A 5L0EA 4LREA 2XR9A 4GTXA 4ZG6A 1ALKA 1URAA 3IDDA 3UN2A 4TN0A 1EI6A 4NWJA 1ELXA 3NKNA 4ZGAA 2IFYA 1EQJA 4CXKA 4KAVA 2GLQA 5DLTA 3TX0A 2GSNA 3WBHA 1EJJA 3IGZB 3NKQA 2XRGA 1ANIA 1N2LA 3NKRA 1AJBA 5LQQA 1KH9A 2GA3A 4KJDA 5L0BA 1URBA 1Y7AA 2W5SA 4LRBA 4ZG7A 4ZG9A 1FSUA 1Y6VA 3NKOA 3OT9A 2GSUA 2W5VA 3IGYB 3NKMA 3BDGA 3M8WA 1ED9A 1KHKA 2W8DA 5TJ3A 2IUCA 4FDJA 4LR9A 3M8ZA 1E2SP 4MHXA 1ALHA 3M7VA 2W5WA 4CXSA 2GSOA 4LR7A 5DLWA 1O99A 4MY4A 3UN3A 2ANHA 1ED8A 4CXUA 3BDFA 3SZYA 3MK1A 4UPHA 4CYRA 3CMRA 3MK0A 3WAXA 2W5XA 1KH5A 1ALIA 1HJKA 2W8SA 3DYCA 4QAXA 1KHNA 4LR2A 2W5QA 3WAYA 5C66A 4MIVA 5GRRA 5LRNA 1AJCA 3B5QA 5EGHA 4KAYA 1AJAA 1EW2A 1KHJA 5IJSA 4KM4A 1HDHA 3WAWA 2QZUA 1P49A 4B56A 2ZKTA 3UNYA 5HRTA 3NVLA 4UPIA 4UPLA 1AUKA 5L0KA 5K4PA 3BDGB 4N7TA 5INHA 3A52A 2IUCB 4LQYA 4LRAA 1ZEBA 4UPKA 1O98A 4YR1A 1ELZA 5DLVA 1ZEFA 3BDHA 3ED4A 3Q3QA 3WAVA 1EW9A 1SHQA 1SHNA 2G9YA 4LR8A 3UO0A 5EGEA 2W5TA 3NKPA 1N2KA 2D1GA 1E3CP 1KH7A 1ELYA 4UORA 5AJ9A 2X98A 1ZEDA 3T01A 1B8JA 3SZZA 5LRMA
chains in the Genus database with same CATH topology
4GTZA 4LRFA 4NWXA 5KXAA 3LXQA 3UN5A 5IJQA 1KHLA 1E1ZP 4UOPA 3DPCA 1ANJA 3KD8A 2W5RA 1K7HA 4KJGA 1E33P 3MK2A 3T02A 2VQRA 1KH4A 4LRDA 5LIAA 3E2DA 1HQAA 5GOVA 1EW8A 4LRCA 3M8YA 4FDIA 1ALJA 3T00A 4CYSA 1AJDA 3TG0A 4GTWA 4UOOA 3TWZA 4GTYA 2RH6A 5L0EA 4LREA 2XR9A 4GTXA 4ZG6A 1ALKA 1URAA 3IDDA 3UN2A 4TN0A 1EI6A 4NWJA 1ELXA 3NKNA 4ZGAA 2IFYA 1EQJA 4CXKA 4KAVA 2GLQA 5DLTA 3TX0A 2GSNA 3WBHA 1EJJA 3IGZB 3NKQA 2XRGA 1ANIA 1N2LA 3NKRA 1AJBA 5LQQA 1KH9A 2GA3A 4KJDA 5L0BA 1URBA 1Y7AA 2W5SA 4LRBA 4ZG7A 4ZG9A 1FSUA 1Y6VA 3NKOA 3OT9A 2GSUA 2W5VA 3IGYB 3NKMA 3BDGA 3M8WA 1ED9A 1KHKA 2W8DA 5TJ3A 2IUCA 4FDJA 4LR9A 3M8ZA 1E2SP 4MHXA 1ALHA 3M7VA 2W5WA 4CXSA 2GSOA 4LR7A 5DLWA 1O99A 4MY4A 3UN3A 2ANHA 1ED8A 4CXUA 3BDFA 3SZYA 3MK1A 4UPHA 4CYRA 3CMRA 3MK0A 3WAXA 2W5XA 1KH5A 1ALIA 1HJKA 2W8SA 3DYCA 4QAXA 1KHNA 4LR2A 2W5QA 3WAYA 5C66A 4MIVA 5GRRA 5LRNA 1AJCA 3B5QA 5EGHA 4KAYA 1AJAA 1EW2A 1KHJA 5IJSA 4KM4A 1HDHA 3WAWA 2QZUA 1P49A 4B56A 2ZKTA 3UNYA 5HRTA 3NVLA 4UPIA 4UPLA 1AUKA 5L0KA 5K4PA 3BDGB 4N7TA 5INHA 3A52A 2IUCB 4LQYA 4LRAA 1ZEBA 4UPKA 1O98A 4YR1A 1ELZA 5DLVA 1ZEFA 3BDHA 3ED4A 3Q3QA 3WAVA 1EW9A 1SHQA 1SHNA 2G9YA 4LR8A 3UO0A 5EGEA 2W5TA 3NKPA 1N2KA 2D1GA 1E3CP 1KH7A 1ELYA 4UORA 5AJ9A 2X98A 1ZEDA 3T01A 1B8JA 3SZZA 5LRMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GTZ A;  4LRF A;  4NWX A;  5KXA A;  3LXQ A;  3UN5 A;  5IJQ A;  1KHL A;  1E1Z P;  4UOP A;  3DPC A;  1ANJ A;  3KD8 A;  2W5R A;  1K7H A;  4KJG A;  1E33 P;  3MK2 A;  3T02 A;  2VQR A;  1KH4 A;  4LRD A;  5LIA A;  3E2D A;  1HQA A;  5GOV A;  1EW8 A;  4LRC A;  3M8Y A;  4FDI A;  1ALJ A;  3T00 A;  4CYS A;  1AJD A;  3TG0 A;  4GTW A;  4UOO A;  3TWZ A;  4GTY A;  2RH6 A;  5L0E A;  4LRE A;  2XR9 A;  4GTX A;  4ZG6 A;  1ALK A;  1URA A;  3IDD A;  3UN2 A;  4TN0 A;  1EI6 A;  4NWJ A;  1ELX A;  3NKN A;  4ZGA A;  2IFY A;  1EQJ A;  4CXK A;  4KAV A;  2GLQ A;  5DLT A;  3TX0 A;  2GSN A;  3WBH A;  1EJJ A;  3IGZ B;  3NKQ A;  2XRG A;  1ANI A;  1N2L A;  3NKR A;  1AJB A;  5LQQ A;  1KH9 A;  2GA3 A;  4KJD A;  5L0B A;  1URB A;  1Y7A A;  2W5S A;  4LRB A;  4ZG7 A;  4ZG9 A;  1FSU A;  1Y6V A;  3NKO A;  3OT9 A;  2GSU A;  2W5V A;  3IGY B;  3NKM A;  3BDG A;  3M8W A;  1ED9 A;  1KHK A;  2W8D A;  5TJ3 A;  2IUC A;  4FDJ A;  4LR9 A;  3M8Z A;  1E2S P;  4MHX A;  1ALH A;  3M7V A;  2W5W A;  4CXS A;  2GSO A;  4LR7 A;  5DLW A;  1O99 A;  4MY4 A;  3UN3 A;  2ANH A;  1ED8 A;  4CXU A;  3BDF A;  3SZY A;  3MK1 A;  4UPH A;  4CYR A;  3CMR A;  3MK0 A;  3WAX A;  2W5X A;  1KH5 A;  1ALI A;  1HJK A;  2W8S A;  3DYC A;  4QAX A;  1KHN A;  4LR2 A;  2W5Q A;  3WAY A;  5C66 A;  4MIV A;  5GRR A;  5LRN A;  1AJC A;  3B5Q A;  5EGH A;  4KAY A;  1AJA A;  1EW2 A;  1KHJ A;  5IJS A;  4KM4 A;  1HDH A;  3WAW A;  2QZU A;  1P49 A;  4B56 A;  2ZKT A;  3UNY A;  5HRT A;  3NVL A;  4UPI A;  4UPL A;  1AUK A;  5L0K A;  5K4P A;  3BDG B;  4N7T A;  5INH A;  3A52 A;  2IUC B;  4LQY A;  4LRA A;  1ZEB A;  4UPK A;  1O98 A;  4YR1 A;  1ELZ A;  5DLV A;  1ZEF A;  3BDH A;  3ED4 A;  3Q3Q A;  3WAV A;  1EW9 A;  1SHQ A;  1SHN A;  2G9Y A;  4LR8 A;  3UO0 A;  5EGE A;  2W5T A;  3NKP A;  1N2K A;  2D1G A;  1E3C P;  1KH7 A;  1ELY A;  4UOR A;  5AJ9 A;  2X98 A;  1ZED A;  3T01 A;  1B8J A;  3SZZ A;  5LRM A; 
#chains in the Genus database with same CATH topology
 4GTZ A;  4LRF A;  4NWX A;  5KXA A;  3LXQ A;  3UN5 A;  5IJQ A;  1KHL A;  1E1Z P;  4UOP A;  3DPC A;  1ANJ A;  3KD8 A;  2W5R A;  1K7H A;  4KJG A;  1E33 P;  3MK2 A;  3T02 A;  2VQR A;  1KH4 A;  4LRD A;  5LIA A;  3E2D A;  1HQA A;  5GOV A;  1EW8 A;  4LRC A;  3M8Y A;  4FDI A;  1ALJ A;  3T00 A;  4CYS A;  1AJD A;  3TG0 A;  4GTW A;  4UOO A;  3TWZ A;  4GTY A;  2RH6 A;  5L0E A;  4LRE A;  2XR9 A;  4GTX A;  4ZG6 A;  1ALK A;  1URA A;  3IDD A;  3UN2 A;  4TN0 A;  1EI6 A;  4NWJ A;  1ELX A;  3NKN A;  4ZGA A;  2IFY A;  1EQJ A;  4CXK A;  4KAV A;  2GLQ A;  5DLT A;  3TX0 A;  2GSN A;  3WBH A;  1EJJ A;  3IGZ B;  3NKQ A;  2XRG A;  1ANI A;  1N2L A;  3NKR A;  1AJB A;  5LQQ A;  1KH9 A;  2GA3 A;  4KJD A;  5L0B A;  1URB A;  1Y7A A;  2W5S A;  4LRB A;  4ZG7 A;  4ZG9 A;  1FSU A;  1Y6V A;  3NKO A;  3OT9 A;  2GSU A;  2W5V A;  3IGY B;  3NKM A;  3BDG A;  3M8W A;  1ED9 A;  1KHK A;  2W8D A;  5TJ3 A;  2IUC A;  4FDJ A;  4LR9 A;  3M8Z A;  1E2S P;  4MHX A;  1ALH A;  3M7V A;  2W5W A;  4CXS A;  2GSO A;  4LR7 A;  5DLW A;  1O99 A;  4MY4 A;  3UN3 A;  2ANH A;  1ED8 A;  4CXU A;  3BDF A;  3SZY A;  3MK1 A;  4UPH A;  4CYR A;  3CMR A;  3MK0 A;  3WAX A;  2W5X A;  1KH5 A;  1ALI A;  1HJK A;  2W8S A;  3DYC A;  4QAX A;  1KHN A;  4LR2 A;  2W5Q A;  3WAY A;  5C66 A;  4MIV A;  5GRR A;  5LRN A;  1AJC A;  3B5Q A;  5EGH A;  4KAY A;  1AJA A;  1EW2 A;  1KHJ A;  5IJS A;  4KM4 A;  1HDH A;  3WAW A;  2QZU A;  1P49 A;  4B56 A;  2ZKT A;  3UNY A;  5HRT A;  3NVL A;  4UPI A;  4UPL A;  1AUK A;  5L0K A;  5K4P A;  3BDG B;  4N7T A;  5INH A;  3A52 A;  2IUC B;  4LQY A;  4LRA A;  1ZEB A;  4UPK A;  1O98 A;  4YR1 A;  1ELZ A;  5DLV A;  1ZEF A;  3BDH A;  3ED4 A;  3Q3Q A;  3WAV A;  1EW9 A;  1SHQ A;  1SHN A;  2G9Y A;  4LR8 A;  3UO0 A;  5EGE A;  2W5T A;  3NKP A;  1N2K A;  2D1G A;  1E3C P;  1KH7 A;  1ELY A;  4UOR A;  5AJ9 A;  2X98 A;  1ZED A;  3T01 A;  1B8J A;  3SZZ A;  5LRM A; 
#chains in the Genus database with same CATH homology
 4GTZ A;  4LRF A;  4NWX A;  5KXA A;  3LXQ A;  3UN5 A;  5IJQ A;  1KHL A;  1E1Z P;  4UOP A;  3DPC A;  1ANJ A;  3KD8 A;  2W5R A;  1K7H A;  4KJG A;  1E33 P;  3MK2 A;  3T02 A;  2VQR A;  1KH4 A;  4LRD A;  5LIA A;  3E2D A;  1HQA A;  5GOV A;  1EW8 A;  4LRC A;  3M8Y A;  4FDI A;  1ALJ A;  3T00 A;  4CYS A;  1AJD A;  3TG0 A;  4GTW A;  4UOO A;  3TWZ A;  4GTY A;  2RH6 A;  5L0E A;  4LRE A;  2XR9 A;  4GTX A;  4ZG6 A;  1ALK A;  1URA A;  3IDD A;  3UN2 A;  4TN0 A;  1EI6 A;  4NWJ A;  1ELX A;  3NKN A;  4ZGA A;  2IFY A;  1EQJ A;  4CXK A;  4KAV A;  2GLQ A;  5DLT A;  3TX0 A;  2GSN A;  3WBH A;  1EJJ A;  3IGZ B;  3NKQ A;  2XRG A;  1ANI A;  1N2L A;  3NKR A;  1AJB A;  5LQQ A;  1KH9 A;  2GA3 A;  4KJD A;  5L0B A;  1URB A;  1Y7A A;  2W5S A;  4LRB A;  4ZG7 A;  4ZG9 A;  1FSU A;  1Y6V A;  3NKO A;  3OT9 A;  2GSU A;  2W5V A;  3IGY B;  3NKM A;  3BDG A;  3M8W A;  1ED9 A;  1KHK A;  2W8D A;  5TJ3 A;  2IUC A;  4FDJ A;  4LR9 A;  3M8Z A;  1E2S P;  4MHX A;  1ALH A;  3M7V A;  2W5W A;  4CXS A;  2GSO A;  4LR7 A;  5DLW A;  1O99 A;  4MY4 A;  3UN3 A;  2ANH A;  1ED8 A;  4CXU A;  3BDF A;  3SZY A;  3MK1 A;  4UPH A;  4CYR A;  3CMR A;  3MK0 A;  3WAX A;  2W5X A;  1KH5 A;  1ALI A;  1HJK A;  2W8S A;  3DYC A;  4QAX A;  1KHN A;  4LR2 A;  2W5Q A;  3WAY A;  5C66 A;  4MIV A;  5GRR A;  5LRN A;  1AJC A;  3B5Q A;  5EGH A;  4KAY A;  1AJA A;  1EW2 A;  1KHJ A;  5IJS A;  4KM4 A;  1HDH A;  3WAW A;  2QZU A;  1P49 A;  4B56 A;  2ZKT A;  3UNY A;  5HRT A;  3NVL A;  4UPI A;  4UPL A;  1AUK A;  5L0K A;  5K4P A;  3BDG B;  4N7T A;  5INH A;  3A52 A;  2IUC B;  4LQY A;  4LRA A;  1ZEB A;  4UPK A;  1O98 A;  4YR1 A;  1ELZ A;  5DLV A;  1ZEF A;  3BDH A;  3ED4 A;  3Q3Q A;  3WAV A;  1EW9 A;  1SHQ A;  1SHN A;  2G9Y A;  4LR8 A;  3UO0 A;  5EGE A;  2W5T A;  3NKP A;  1N2K A;  2D1G A;  1E3C P;  1KH7 A;  1ELY A;  4UOR A;  5AJ9 A;  2X98 A;  1ZED A;  3T01 A;  1B8J A;  3SZZ A;  5LRM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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