1Y6VA

Structure of e. coli alkaline phosphatase in presence of cobalt at 1.60 a resolution
Total Genus 163
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
163
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Metal Specificity Is Correlated with Two Crucial Active Site Residues in Escherichia coli Alkaline Phosphatase(,).
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus 163
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-12-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1y6vA00
4MHXA 4B56A 2ANHA 3MK1A 2IUCA 3BDFA 1N2KA 5HRTA 4YR1A 5K4PA 1E3CP 3NKOA 1AJCA 3TWZA 4KM4A 3UNYA 3WAWA 1K7HA 1AJDA 5INHA 3IDDA 4UPIA 4MY4A 1FSUA 4LR8A 4N7TA 5L0BA 1ALKA 2G9YA 3NKQA 4LR2A 3UN3A 2W8DA 3BDGB 1E2SP 4LRCA 1KH5A 2D1GA 5IJQA 4CXSA 3M7VA 3A52A 1SHNA 5LIAA 5EGHA 3WBHA 1ELYA 5LRMA 1ZEBA 4LR7A 4LRDA 5LRNA 4KAYA 5L0EA 4GTXA 1ZEDA 1EW9A 2GA3A 4ZG7A 4QAXA 4CXUA 4GTWA 5KXAA 4LQYA 5LQQA 2W5SA 1P49A 4UPLA 2W5VA 1N2LA 1EI6A 5DLWA 4LR9A 3NKPA 4UOPA 3WAVA 4GTYA 3NKMA 5DLTA 3M8WA 5GOVA 5TJ3A 3M8ZA 4FDIA 5AJ9A 4CYSA 3WAYA 1ZEFA 1HJKA 1O98A 3T02A 2W5XA 2ZKTA 5C66A 4UOOA 4MIVA 3BDHA 3ED4A 3NVLA 1HDHA 4CXKA 2IUCB 1O99A 4KAVA 4LRBA 1ALHA 1ELXA 1KHNA 2W8SA 3NKRA 4LRAA 4ZGAA 4NWJA 2X98A 1AJBA 1EW2A 1KH4A 1EQJA 2IFYA 3BDGA 3CMRA 1E1ZP 1URBA 4ZG9A 2VQRA 4KJGA 4LREA 2RH6A 4NWXA 3Q3QA 1KHJA 1KHKA 3OT9A 1ALIA 4GTZA 3T01A 2XRGA 1Y6VA 3KD8A 4UORA 2XR9A 4KJDA 1KH7A 5L0KA 1EW8A 3B5QA 3UN5A 1URAA 3M8YA 1ED8A 1EJJA 3IGYB 4UPHA 1ELZA 5EGEA 1ALJA 1E33P 1KHLA 2GLQA 2GSOA 2QZUA 2W5TA 3MK2A 4FDJA 4ZG6A 5IJSA 3MK0A 1AJAA 1B8JA 3UN2A 3SZYA 3TG0A 2W5WA 4UPKA 3TX0A 5GRRA 4LRFA 1ANJA 2GSNA 3IGZB 4TN0A 3SZZA 3UO0A 4CYRA 1KH9A 2W5RA 1ANIA 5DLVA 1ED9A 1HQAA 3DYCA 3T00A 3NKNA 3WAXA 3E2DA 3LXQA 1AUKA 1SHQA 2GSUA 3DPCA 2W5QA 1Y7AA
chains in the Genus database with same CATH superfamily
4MHXA 4B56A 2ANHA 3MK1A 2IUCA 3BDFA 1N2KA 5HRTA 4YR1A 5K4PA 1E3CP 3NKOA 1AJCA 3TWZA 4KM4A 3UNYA 3WAWA 1K7HA 1AJDA 5INHA 3IDDA 4UPIA 4MY4A 1FSUA 4LR8A 4N7TA 5L0BA 1ALKA 2G9YA 3NKQA 4LR2A 3UN3A 2W8DA 3BDGB 1E2SP 4LRCA 1KH5A 2D1GA 5IJQA 4CXSA 3M7VA 3A52A 1SHNA 5LIAA 5EGHA 3WBHA 1ELYA 5LRMA 1ZEBA 4LR7A 4LRDA 5LRNA 4KAYA 5L0EA 4GTXA 1ZEDA 1EW9A 2GA3A 4ZG7A 4QAXA 4CXUA 4GTWA 5KXAA 4LQYA 5LQQA 2W5SA 1P49A 4UPLA 2W5VA 1N2LA 1EI6A 5DLWA 4LR9A 3NKPA 4UOPA 3WAVA 4GTYA 3NKMA 5DLTA 3M8WA 5GOVA 5TJ3A 3M8ZA 4FDIA 5AJ9A 4CYSA 3WAYA 1ZEFA 1HJKA 1O98A 3T02A 2W5XA 2ZKTA 5C66A 4UOOA 4MIVA 3BDHA 3ED4A 3NVLA 1HDHA 4CXKA 2IUCB 1O99A 4KAVA 4LRBA 1ALHA 1ELXA 1KHNA 2W8SA 3NKRA 4LRAA 4ZGAA 4NWJA 2X98A 1AJBA 1EW2A 1KH4A 1EQJA 2IFYA 3BDGA 3CMRA 1E1ZP 1URBA 4ZG9A 2VQRA 4KJGA 4LREA 2RH6A 4NWXA 3Q3QA 1KHJA 1KHKA 3OT9A 1ALIA 4GTZA 3T01A 2XRGA 1Y6VA 3KD8A 4UORA 2XR9A 4KJDA 1KH7A 5L0KA 1EW8A 3B5QA 3UN5A 1URAA 3M8YA 1ED8A 1EJJA 3IGYB 4UPHA 1ELZA 5EGEA 1ALJA 1E33P 1KHLA 2GLQA 2GSOA 2QZUA 2W5TA 3MK2A 4FDJA 4ZG6A 5IJSA 3MK0A 1AJAA 1B8JA 3UN2A 3SZYA 3TG0A 2W5WA 4UPKA 3TX0A 5GRRA 4LRFA 1ANJA 2GSNA 3IGZB 4TN0A 3SZZA 3UO0A 4CYRA 1KH9A 2W5RA 1ANIA 5DLVA 1ED9A 1HQAA 3DYCA 3T00A 3NKNA 3WAXA 3E2DA 3LXQA 1AUKA 1SHQA 2GSUA 3DPCA 2W5QA 1Y7AA
chains in the Genus database with same CATH topology
4MHXA 4B56A 2ANHA 3MK1A 2IUCA 3BDFA 1N2KA 5HRTA 4YR1A 5K4PA 1E3CP 3NKOA 1AJCA 3TWZA 4KM4A 3UNYA 3WAWA 1K7HA 1AJDA 5INHA 3IDDA 4UPIA 4MY4A 1FSUA 4LR8A 4N7TA 5L0BA 1ALKA 2G9YA 3NKQA 4LR2A 3UN3A 2W8DA 3BDGB 1E2SP 4LRCA 1KH5A 2D1GA 5IJQA 4CXSA 3M7VA 3A52A 1SHNA 5LIAA 5EGHA 3WBHA 1ELYA 5LRMA 1ZEBA 4LR7A 4LRDA 5LRNA 4KAYA 5L0EA 4GTXA 1ZEDA 1EW9A 2GA3A 4ZG7A 4QAXA 4CXUA 4GTWA 5KXAA 4LQYA 5LQQA 2W5SA 1P49A 4UPLA 2W5VA 1N2LA 1EI6A 5DLWA 4LR9A 3NKPA 4UOPA 3WAVA 4GTYA 3NKMA 5DLTA 3M8WA 5GOVA 5TJ3A 3M8ZA 4FDIA 5AJ9A 4CYSA 3WAYA 1ZEFA 1HJKA 1O98A 3T02A 2W5XA 2ZKTA 5C66A 4UOOA 4MIVA 3BDHA 3ED4A 3NVLA 1HDHA 4CXKA 2IUCB 1O99A 4KAVA 4LRBA 1ALHA 1ELXA 1KHNA 2W8SA 3NKRA 4LRAA 4ZGAA 4NWJA 2X98A 1AJBA 1EW2A 1KH4A 1EQJA 2IFYA 3BDGA 3CMRA 1E1ZP 1URBA 4ZG9A 2VQRA 4KJGA 4LREA 2RH6A 4NWXA 3Q3QA 1KHJA 1KHKA 3OT9A 1ALIA 4GTZA 3T01A 2XRGA 1Y6VA 3KD8A 4UORA 2XR9A 4KJDA 1KH7A 5L0KA 1EW8A 3B5QA 3UN5A 1URAA 3M8YA 1ED8A 1EJJA 3IGYB 4UPHA 1ELZA 5EGEA 1ALJA 1E33P 1KHLA 2GLQA 2GSOA 2QZUA 2W5TA 3MK2A 4FDJA 4ZG6A 5IJSA 3MK0A 1AJAA 1B8JA 3UN2A 3SZYA 3TG0A 2W5WA 4UPKA 3TX0A 5GRRA 4LRFA 1ANJA 2GSNA 3IGZB 4TN0A 3SZZA 3UO0A 4CYRA 1KH9A 2W5RA 1ANIA 5DLVA 1ED9A 1HQAA 3DYCA 3T00A 3NKNA 3WAXA 3E2DA 3LXQA 1AUKA 1SHQA 2GSUA 3DPCA 2W5QA 1Y7AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4MHX A;  4B56 A;  2ANH A;  3MK1 A;  2IUC A;  3BDF A;  1N2K A;  5HRT A;  4YR1 A;  5K4P A;  1E3C P;  3NKO A;  1AJC A;  3TWZ A;  4KM4 A;  3UNY A;  3WAW A;  1K7H A;  1AJD A;  5INH A;  3IDD A;  4UPI A;  4MY4 A;  1FSU A;  4LR8 A;  4N7T A;  5L0B A;  1ALK A;  2G9Y A;  3NKQ A;  4LR2 A;  3UN3 A;  2W8D A;  3BDG B;  1E2S P;  4LRC A;  1KH5 A;  2D1G A;  5IJQ A;  4CXS A;  3M7V A;  3A52 A;  1SHN A;  5LIA A;  5EGH A;  3WBH A;  1ELY A;  5LRM A;  1ZEB A;  4LR7 A;  4LRD A;  5LRN A;  4KAY A;  5L0E A;  4GTX A;  1ZED A;  1EW9 A;  2GA3 A;  4ZG7 A;  4QAX A;  4CXU A;  4GTW A;  5KXA A;  4LQY A;  5LQQ A;  2W5S A;  1P49 A;  4UPL A;  2W5V A;  1N2L A;  1EI6 A;  5DLW A;  4LR9 A;  3NKP A;  4UOP A;  3WAV A;  4GTY A;  3NKM A;  5DLT A;  3M8W A;  5GOV A;  5TJ3 A;  3M8Z A;  4FDI A;  5AJ9 A;  4CYS A;  3WAY A;  1ZEF A;  1HJK A;  1O98 A;  3T02 A;  2W5X A;  2ZKT A;  5C66 A;  4UOO A;  4MIV A;  3BDH A;  3ED4 A;  3NVL A;  1HDH A;  4CXK A;  2IUC B;  1O99 A;  4KAV A;  4LRB A;  1ALH A;  1ELX A;  1KHN A;  2W8S A;  3NKR A;  4LRA A;  4ZGA A;  4NWJ A;  2X98 A;  1AJB A;  1EW2 A;  1KH4 A;  1EQJ A;  2IFY A;  3BDG A;  3CMR A;  1E1Z P;  1URB A;  4ZG9 A;  2VQR A;  4KJG A;  4LRE A;  2RH6 A;  4NWX A;  3Q3Q A;  1KHJ A;  1KHK A;  3OT9 A;  1ALI A;  4GTZ A;  3T01 A;  2XRG A;  1Y6V A;  3KD8 A;  4UOR A;  2XR9 A;  4KJD A;  1KH7 A;  5L0K A;  1EW8 A;  3B5Q A;  3UN5 A;  1URA A;  3M8Y A;  1ED8 A;  1EJJ A;  3IGY B;  4UPH A;  1ELZ A;  5EGE A;  1ALJ A;  1E33 P;  1KHL A;  2GLQ A;  2GSO A;  2QZU A;  2W5T A;  3MK2 A;  4FDJ A;  4ZG6 A;  5IJS A;  3MK0 A;  1AJA A;  1B8J A;  3UN2 A;  3SZY A;  3TG0 A;  2W5W A;  4UPK A;  3TX0 A;  5GRR A;  4LRF A;  1ANJ A;  2GSN A;  3IGZ B;  4TN0 A;  3SZZ A;  3UO0 A;  4CYR A;  1KH9 A;  2W5R A;  1ANI A;  5DLV A;  1ED9 A;  1HQA A;  3DYC A;  3T00 A;  3NKN A;  3WAX A;  3E2D A;  3LXQ A;  1AUK A;  1SHQ A;  2GSU A;  3DPC A;  2W5Q A;  1Y7A A; 
#chains in the Genus database with same CATH topology
 4MHX A;  4B56 A;  2ANH A;  3MK1 A;  2IUC A;  3BDF A;  1N2K A;  5HRT A;  4YR1 A;  5K4P A;  1E3C P;  3NKO A;  1AJC A;  3TWZ A;  4KM4 A;  3UNY A;  3WAW A;  1K7H A;  1AJD A;  5INH A;  3IDD A;  4UPI A;  4MY4 A;  1FSU A;  4LR8 A;  4N7T A;  5L0B A;  1ALK A;  2G9Y A;  3NKQ A;  4LR2 A;  3UN3 A;  2W8D A;  3BDG B;  1E2S P;  4LRC A;  1KH5 A;  2D1G A;  5IJQ A;  4CXS A;  3M7V A;  3A52 A;  1SHN A;  5LIA A;  5EGH A;  3WBH A;  1ELY A;  5LRM A;  1ZEB A;  4LR7 A;  4LRD A;  5LRN A;  4KAY A;  5L0E A;  4GTX A;  1ZED A;  1EW9 A;  2GA3 A;  4ZG7 A;  4QAX A;  4CXU A;  4GTW A;  5KXA A;  4LQY A;  5LQQ A;  2W5S A;  1P49 A;  4UPL A;  2W5V A;  1N2L A;  1EI6 A;  5DLW A;  4LR9 A;  3NKP A;  4UOP A;  3WAV A;  4GTY A;  3NKM A;  5DLT A;  3M8W A;  5GOV A;  5TJ3 A;  3M8Z A;  4FDI A;  5AJ9 A;  4CYS A;  3WAY A;  1ZEF A;  1HJK A;  1O98 A;  3T02 A;  2W5X A;  2ZKT A;  5C66 A;  4UOO A;  4MIV A;  3BDH A;  3ED4 A;  3NVL A;  1HDH A;  4CXK A;  2IUC B;  1O99 A;  4KAV A;  4LRB A;  1ALH A;  1ELX A;  1KHN A;  2W8S A;  3NKR A;  4LRA A;  4ZGA A;  4NWJ A;  2X98 A;  1AJB A;  1EW2 A;  1KH4 A;  1EQJ A;  2IFY A;  3BDG A;  3CMR A;  1E1Z P;  1URB A;  4ZG9 A;  2VQR A;  4KJG A;  4LRE A;  2RH6 A;  4NWX A;  3Q3Q A;  1KHJ A;  1KHK A;  3OT9 A;  1ALI A;  4GTZ A;  3T01 A;  2XRG A;  1Y6V A;  3KD8 A;  4UOR A;  2XR9 A;  4KJD A;  1KH7 A;  5L0K A;  1EW8 A;  3B5Q A;  3UN5 A;  1URA A;  3M8Y A;  1ED8 A;  1EJJ A;  3IGY B;  4UPH A;  1ELZ A;  5EGE A;  1ALJ A;  1E33 P;  1KHL A;  2GLQ A;  2GSO A;  2QZU A;  2W5T A;  3MK2 A;  4FDJ A;  4ZG6 A;  5IJS A;  3MK0 A;  1AJA A;  1B8J A;  3UN2 A;  3SZY A;  3TG0 A;  2W5W A;  4UPK A;  3TX0 A;  5GRR A;  4LRF A;  1ANJ A;  2GSN A;  3IGZ B;  4TN0 A;  3SZZ A;  3UO0 A;  4CYR A;  1KH9 A;  2W5R A;  1ANI A;  5DLV A;  1ED9 A;  1HQA A;  3DYC A;  3T00 A;  3NKN A;  3WAX A;  3E2D A;  3LXQ A;  1AUK A;  1SHQ A;  2GSU A;  3DPC A;  2W5Q A;  1Y7A A; 
#chains in the Genus database with same CATH homology
 4MHX A;  4B56 A;  2ANH A;  3MK1 A;  2IUC A;  3BDF A;  1N2K A;  5HRT A;  4YR1 A;  5K4P A;  1E3C P;  3NKO A;  1AJC A;  3TWZ A;  4KM4 A;  3UNY A;  3WAW A;  1K7H A;  1AJD A;  5INH A;  3IDD A;  4UPI A;  4MY4 A;  1FSU A;  4LR8 A;  4N7T A;  5L0B A;  1ALK A;  2G9Y A;  3NKQ A;  4LR2 A;  3UN3 A;  2W8D A;  3BDG B;  1E2S P;  4LRC A;  1KH5 A;  2D1G A;  5IJQ A;  4CXS A;  3M7V A;  3A52 A;  1SHN A;  5LIA A;  5EGH A;  3WBH A;  1ELY A;  5LRM A;  1ZEB A;  4LR7 A;  4LRD A;  5LRN A;  4KAY A;  5L0E A;  4GTX A;  1ZED A;  1EW9 A;  2GA3 A;  4ZG7 A;  4QAX A;  4CXU A;  4GTW A;  5KXA A;  4LQY A;  5LQQ A;  2W5S A;  1P49 A;  4UPL A;  2W5V A;  1N2L A;  1EI6 A;  5DLW A;  4LR9 A;  3NKP A;  4UOP A;  3WAV A;  4GTY A;  3NKM A;  5DLT A;  3M8W A;  5GOV A;  5TJ3 A;  3M8Z A;  4FDI A;  5AJ9 A;  4CYS A;  3WAY A;  1ZEF A;  1HJK A;  1O98 A;  3T02 A;  2W5X A;  2ZKT A;  5C66 A;  4UOO A;  4MIV A;  3BDH A;  3ED4 A;  3NVL A;  1HDH A;  4CXK A;  2IUC B;  1O99 A;  4KAV A;  4LRB A;  1ALH A;  1ELX A;  1KHN A;  2W8S A;  3NKR A;  4LRA A;  4ZGA A;  4NWJ A;  2X98 A;  1AJB A;  1EW2 A;  1KH4 A;  1EQJ A;  2IFY A;  3BDG A;  3CMR A;  1E1Z P;  1URB A;  4ZG9 A;  2VQR A;  4KJG A;  4LRE A;  2RH6 A;  4NWX A;  3Q3Q A;  1KHJ A;  1KHK A;  3OT9 A;  1ALI A;  4GTZ A;  3T01 A;  2XRG A;  1Y6V A;  3KD8 A;  4UOR A;  2XR9 A;  4KJD A;  1KH7 A;  5L0K A;  1EW8 A;  3B5Q A;  3UN5 A;  1URA A;  3M8Y A;  1ED8 A;  1EJJ A;  3IGY B;  4UPH A;  1ELZ A;  5EGE A;  1ALJ A;  1E33 P;  1KHL A;  2GLQ A;  2GSO A;  2QZU A;  2W5T A;  3MK2 A;  4FDJ A;  4ZG6 A;  5IJS A;  3MK0 A;  1AJA A;  1B8J A;  3UN2 A;  3SZY A;  3TG0 A;  2W5W A;  4UPK A;  3TX0 A;  5GRR A;  4LRF A;  1ANJ A;  2GSN A;  3IGZ B;  4TN0 A;  3SZZ A;  3UO0 A;  4CYR A;  1KH9 A;  2W5R A;  1ANI A;  5DLV A;  1ED9 A;  1HQA A;  3DYC A;  3T00 A;  3NKN A;  3WAX A;  3E2D A;  3LXQ A;  1AUK A;  1SHQ A;  2GSU A;  3DPC A;  2W5Q A;  1Y7A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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