1EW9A

Alkaline phosphatase (e.c. 3.1.3.1) complex with mercaptomethyl phosphonate
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
total genus 159
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew9A00
3T02A 3M8WA 4CYRA 4UOPA 5LQQA 4KAVA 3B5QA 4CXSA 1KH7A 2IFYA 3OT9A 5L0BA 4UPLA 3IDDA 3Q3QA 4QAXA 1EW8A 1E1ZP 3BDGA 3NKPA 4KM4A 1P49A 5IJQA 1ALHA 4MY4A 3NKMA 4UORA 4LR8A 1ZEDA 1EW2A 1SHQA 4LRFA 2W5RA 3M8ZA 3NVLA 3T01A 1KHLA 4ZGAA 3KD8A 1ZEFA 4LRBA 3UN5A 4LRAA 2GLQA 1N2LA 4YR1A 2GA3A 2G9YA 2QZUA 2IUCB 1AJAA 1AJBA 1ZEBA 1HDHA 3CMRA 3IGZB 1B8JA 4B56A 4UOOA 1ANJA 5DLTA 3WBHA 3ED4A 2GSUA 2W5XA 1E3CP 2XR9A 3UO0A 3BDGB 4UPHA 5C66A 4ZG6A 1ELZA 3A52A 2IUCA 3UNYA 4LREA 5TJ3A 2GSOA 4GTWA 4LRDA 1KHJA 3M7VA 5INHA 5DLVA 5GRRA 1ELXA 4N7TA 2X98A 3NKRA 3UN3A 4CXKA 1ALJA 4GTXA 4KJDA 5LIAA 2ANHA 3BDFA 3MK0A 3WAVA 3WAWA 1ALIA 4UPIA 4GTYA 2W5WA 1AUKA 3NKOA 2GSNA 1ELYA 3UN2A 3M8YA 1KHNA 1O98A 5EGEA 5L0KA 2D1GA 4NWXA 4GTZA 5IJSA 4LR9A 1SHNA 1AJDA 1N2KA 4ZG7A 5EGHA 3MK1A 2W8DA 5DLWA 1HQAA 3TWZA 4FDJA 3TG0A 4LQYA 1EI6A 1KH9A 1EW9A 1URAA 4FDIA 3DPCA 4LRCA 3WAYA 3E2DA 1EJJA 1KH4A 1E33P 4MIVA 1Y7AA 3WAXA 1URBA 1E2SP 3NKNA 5HRTA 1ANIA 2XRGA 5L0EA 1KHKA 5GOVA 4KAYA 2VQRA 3LXQA 3SZZA 1O99A 1FSUA 4KJGA 4LR2A 2ZKTA 1Y6VA 3NKQA 3DYCA 5K4PA 1HJKA 3MK2A 4MHXA 4UPKA 2W5QA 1AJCA 5KXAA 2W8SA 1ED9A 2RH6A 5LRNA 4LR7A 3T00A 5LRMA 2W5VA 1KH5A 4CYSA 4TN0A 3IGYB 2W5SA 4NWJA 1ALKA 2W5TA 1ED8A 3SZYA 5AJ9A 3TX0A 1EQJA 4CXUA 4ZG9A 1K7HA 3BDHA
chains in the Genus database with same CATH superfamily
3T02A 3M8WA 4CYRA 4UOPA 5LQQA 4KAVA 3B5QA 4CXSA 1KH7A 2IFYA 3OT9A 5L0BA 4UPLA 3IDDA 3Q3QA 4QAXA 1EW8A 1E1ZP 3BDGA 3NKPA 4KM4A 1P49A 5IJQA 1ALHA 4MY4A 3NKMA 4UORA 4LR8A 1ZEDA 1EW2A 1SHQA 4LRFA 2W5RA 3M8ZA 3NVLA 3T01A 1KHLA 4ZGAA 3KD8A 1ZEFA 4LRBA 3UN5A 4LRAA 2GLQA 1N2LA 4YR1A 2GA3A 2G9YA 2QZUA 2IUCB 1AJAA 1AJBA 1ZEBA 1HDHA 3CMRA 3IGZB 1B8JA 4B56A 4UOOA 1ANJA 5DLTA 3WBHA 3ED4A 2GSUA 2W5XA 1E3CP 2XR9A 3UO0A 3BDGB 4UPHA 5C66A 4ZG6A 1ELZA 3A52A 2IUCA 3UNYA 4LREA 5TJ3A 2GSOA 4GTWA 4LRDA 1KHJA 3M7VA 5INHA 5DLVA 5GRRA 1ELXA 4N7TA 2X98A 3NKRA 3UN3A 4CXKA 1ALJA 4GTXA 4KJDA 5LIAA 2ANHA 3BDFA 3MK0A 3WAVA 3WAWA 1ALIA 4UPIA 4GTYA 2W5WA 1AUKA 3NKOA 2GSNA 1ELYA 3UN2A 3M8YA 1KHNA 1O98A 5EGEA 5L0KA 2D1GA 4NWXA 4GTZA 5IJSA 4LR9A 1SHNA 1AJDA 1N2KA 4ZG7A 5EGHA 3MK1A 2W8DA 5DLWA 1HQAA 3TWZA 4FDJA 3TG0A 4LQYA 1EI6A 1KH9A 1EW9A 1URAA 4FDIA 3DPCA 4LRCA 3WAYA 3E2DA 1EJJA 1KH4A 1E33P 4MIVA 1Y7AA 3WAXA 1URBA 1E2SP 3NKNA 5HRTA 1ANIA 2XRGA 5L0EA 1KHKA 5GOVA 4KAYA 2VQRA 3LXQA 3SZZA 1O99A 1FSUA 4KJGA 4LR2A 2ZKTA 1Y6VA 3NKQA 3DYCA 5K4PA 1HJKA 3MK2A 4MHXA 4UPKA 2W5QA 1AJCA 5KXAA 2W8SA 1ED9A 2RH6A 5LRNA 4LR7A 3T00A 5LRMA 2W5VA 1KH5A 4CYSA 4TN0A 3IGYB 2W5SA 4NWJA 1ALKA 2W5TA 1ED8A 3SZYA 5AJ9A 3TX0A 1EQJA 4CXUA 4ZG9A 1K7HA 3BDHA
chains in the Genus database with same CATH topology
3T02A 3M8WA 4CYRA 4UOPA 5LQQA 4KAVA 3B5QA 4CXSA 1KH7A 2IFYA 3OT9A 5L0BA 4UPLA 3IDDA 3Q3QA 4QAXA 1EW8A 1E1ZP 3BDGA 3NKPA 4KM4A 1P49A 5IJQA 1ALHA 4MY4A 3NKMA 4UORA 4LR8A 1ZEDA 1EW2A 1SHQA 4LRFA 2W5RA 3M8ZA 3NVLA 3T01A 1KHLA 4ZGAA 3KD8A 1ZEFA 4LRBA 3UN5A 4LRAA 2GLQA 1N2LA 4YR1A 2GA3A 2G9YA 2QZUA 2IUCB 1AJAA 1AJBA 1ZEBA 1HDHA 3CMRA 3IGZB 1B8JA 4B56A 4UOOA 1ANJA 5DLTA 3WBHA 3ED4A 2GSUA 2W5XA 1E3CP 2XR9A 3UO0A 3BDGB 4UPHA 5C66A 4ZG6A 1ELZA 3A52A 2IUCA 3UNYA 4LREA 5TJ3A 2GSOA 4GTWA 4LRDA 1KHJA 3M7VA 5INHA 5DLVA 5GRRA 1ELXA 4N7TA 2X98A 3NKRA 3UN3A 4CXKA 1ALJA 4GTXA 4KJDA 5LIAA 2ANHA 3BDFA 3MK0A 3WAVA 3WAWA 1ALIA 4UPIA 4GTYA 2W5WA 1AUKA 3NKOA 2GSNA 1ELYA 3UN2A 3M8YA 1KHNA 1O98A 5EGEA 5L0KA 2D1GA 4NWXA 4GTZA 5IJSA 4LR9A 1SHNA 1AJDA 1N2KA 4ZG7A 5EGHA 3MK1A 2W8DA 5DLWA 1HQAA 3TWZA 4FDJA 3TG0A 4LQYA 1EI6A 1KH9A 1EW9A 1URAA 4FDIA 3DPCA 4LRCA 3WAYA 3E2DA 1EJJA 1KH4A 1E33P 4MIVA 1Y7AA 3WAXA 1URBA 1E2SP 3NKNA 5HRTA 1ANIA 2XRGA 5L0EA 1KHKA 5GOVA 4KAYA 2VQRA 3LXQA 3SZZA 1O99A 1FSUA 4KJGA 4LR2A 2ZKTA 1Y6VA 3NKQA 3DYCA 5K4PA 1HJKA 3MK2A 4MHXA 4UPKA 2W5QA 1AJCA 5KXAA 2W8SA 1ED9A 2RH6A 5LRNA 4LR7A 3T00A 5LRMA 2W5VA 1KH5A 4CYSA 4TN0A 3IGYB 2W5SA 4NWJA 1ALKA 2W5TA 1ED8A 3SZYA 5AJ9A 3TX0A 1EQJA 4CXUA 4ZG9A 1K7HA 3BDHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3T02 A;  3M8W A;  4CYR A;  4UOP A;  5LQQ A;  4KAV A;  3B5Q A;  4CXS A;  1KH7 A;  2IFY A;  3OT9 A;  5L0B A;  4UPL A;  3IDD A;  3Q3Q A;  4QAX A;  1EW8 A;  1E1Z P;  3BDG A;  3NKP A;  4KM4 A;  1P49 A;  5IJQ A;  1ALH A;  4MY4 A;  3NKM A;  4UOR A;  4LR8 A;  1ZED A;  1EW2 A;  1SHQ A;  4LRF A;  2W5R A;  3M8Z A;  3NVL A;  3T01 A;  1KHL A;  4ZGA A;  3KD8 A;  1ZEF A;  4LRB A;  3UN5 A;  4LRA A;  2GLQ A;  1N2L A;  4YR1 A;  2GA3 A;  2G9Y A;  2QZU A;  2IUC B;  1AJA A;  1AJB A;  1ZEB A;  1HDH A;  3CMR A;  3IGZ B;  1B8J A;  4B56 A;  4UOO A;  1ANJ A;  5DLT A;  3WBH A;  3ED4 A;  2GSU A;  2W5X A;  1E3C P;  2XR9 A;  3UO0 A;  3BDG B;  4UPH A;  5C66 A;  4ZG6 A;  1ELZ A;  3A52 A;  2IUC A;  3UNY A;  4LRE A;  5TJ3 A;  2GSO A;  4GTW A;  4LRD A;  1KHJ A;  3M7V A;  5INH A;  5DLV A;  5GRR A;  1ELX A;  4N7T A;  2X98 A;  3NKR A;  3UN3 A;  4CXK A;  1ALJ A;  4GTX A;  4KJD A;  5LIA A;  2ANH A;  3BDF A;  3MK0 A;  3WAV A;  3WAW A;  1ALI A;  4UPI A;  4GTY A;  2W5W A;  1AUK A;  3NKO A;  2GSN A;  1ELY A;  3UN2 A;  3M8Y A;  1KHN A;  1O98 A;  5EGE A;  5L0K A;  2D1G A;  4NWX A;  4GTZ A;  5IJS A;  4LR9 A;  1SHN A;  1AJD A;  1N2K A;  4ZG7 A;  5EGH A;  3MK1 A;  2W8D A;  5DLW A;  1HQA A;  3TWZ A;  4FDJ A;  3TG0 A;  4LQY A;  1EI6 A;  1KH9 A;  1EW9 A;  1URA A;  4FDI A;  3DPC A;  4LRC A;  3WAY A;  3E2D A;  1EJJ A;  1KH4 A;  1E33 P;  4MIV A;  1Y7A A;  3WAX A;  1URB A;  1E2S P;  3NKN A;  5HRT A;  1ANI A;  2XRG A;  5L0E A;  1KHK A;  5GOV A;  4KAY A;  2VQR A;  3LXQ A;  3SZZ A;  1O99 A;  1FSU A;  4KJG A;  4LR2 A;  2ZKT A;  1Y6V A;  3NKQ A;  3DYC A;  5K4P A;  1HJK A;  3MK2 A;  4MHX A;  4UPK A;  2W5Q A;  1AJC A;  5KXA A;  2W8S A;  1ED9 A;  2RH6 A;  5LRN A;  4LR7 A;  3T00 A;  5LRM A;  2W5V A;  1KH5 A;  4CYS A;  4TN0 A;  3IGY B;  2W5S A;  4NWJ A;  1ALK A;  2W5T A;  1ED8 A;  3SZY A;  5AJ9 A;  3TX0 A;  1EQJ A;  4CXU A;  4ZG9 A;  1K7H A;  3BDH A; 
#chains in the Genus database with same CATH topology
 3T02 A;  3M8W A;  4CYR A;  4UOP A;  5LQQ A;  4KAV A;  3B5Q A;  4CXS A;  1KH7 A;  2IFY A;  3OT9 A;  5L0B A;  4UPL A;  3IDD A;  3Q3Q A;  4QAX A;  1EW8 A;  1E1Z P;  3BDG A;  3NKP A;  4KM4 A;  1P49 A;  5IJQ A;  1ALH A;  4MY4 A;  3NKM A;  4UOR A;  4LR8 A;  1ZED A;  1EW2 A;  1SHQ A;  4LRF A;  2W5R A;  3M8Z A;  3NVL A;  3T01 A;  1KHL A;  4ZGA A;  3KD8 A;  1ZEF A;  4LRB A;  3UN5 A;  4LRA A;  2GLQ A;  1N2L A;  4YR1 A;  2GA3 A;  2G9Y A;  2QZU A;  2IUC B;  1AJA A;  1AJB A;  1ZEB A;  1HDH A;  3CMR A;  3IGZ B;  1B8J A;  4B56 A;  4UOO A;  1ANJ A;  5DLT A;  3WBH A;  3ED4 A;  2GSU A;  2W5X A;  1E3C P;  2XR9 A;  3UO0 A;  3BDG B;  4UPH A;  5C66 A;  4ZG6 A;  1ELZ A;  3A52 A;  2IUC A;  3UNY A;  4LRE A;  5TJ3 A;  2GSO A;  4GTW A;  4LRD A;  1KHJ A;  3M7V A;  5INH A;  5DLV A;  5GRR A;  1ELX A;  4N7T A;  2X98 A;  3NKR A;  3UN3 A;  4CXK A;  1ALJ A;  4GTX A;  4KJD A;  5LIA A;  2ANH A;  3BDF A;  3MK0 A;  3WAV A;  3WAW A;  1ALI A;  4UPI A;  4GTY A;  2W5W A;  1AUK A;  3NKO A;  2GSN A;  1ELY A;  3UN2 A;  3M8Y A;  1KHN A;  1O98 A;  5EGE A;  5L0K A;  2D1G A;  4NWX A;  4GTZ A;  5IJS A;  4LR9 A;  1SHN A;  1AJD A;  1N2K A;  4ZG7 A;  5EGH A;  3MK1 A;  2W8D A;  5DLW A;  1HQA A;  3TWZ A;  4FDJ A;  3TG0 A;  4LQY A;  1EI6 A;  1KH9 A;  1EW9 A;  1URA A;  4FDI A;  3DPC A;  4LRC A;  3WAY A;  3E2D A;  1EJJ A;  1KH4 A;  1E33 P;  4MIV A;  1Y7A A;  3WAX A;  1URB A;  1E2S P;  3NKN A;  5HRT A;  1ANI A;  2XRG A;  5L0E A;  1KHK A;  5GOV A;  4KAY A;  2VQR A;  3LXQ A;  3SZZ A;  1O99 A;  1FSU A;  4KJG A;  4LR2 A;  2ZKT A;  1Y6V A;  3NKQ A;  3DYC A;  5K4P A;  1HJK A;  3MK2 A;  4MHX A;  4UPK A;  2W5Q A;  1AJC A;  5KXA A;  2W8S A;  1ED9 A;  2RH6 A;  5LRN A;  4LR7 A;  3T00 A;  5LRM A;  2W5V A;  1KH5 A;  4CYS A;  4TN0 A;  3IGY B;  2W5S A;  4NWJ A;  1ALK A;  2W5T A;  1ED8 A;  3SZY A;  5AJ9 A;  3TX0 A;  1EQJ A;  4CXU A;  4ZG9 A;  1K7H A;  3BDH A; 
#chains in the Genus database with same CATH homology
 3T02 A;  3M8W A;  4CYR A;  4UOP A;  5LQQ A;  4KAV A;  3B5Q A;  4CXS A;  1KH7 A;  2IFY A;  3OT9 A;  5L0B A;  4UPL A;  3IDD A;  3Q3Q A;  4QAX A;  1EW8 A;  1E1Z P;  3BDG A;  3NKP A;  4KM4 A;  1P49 A;  5IJQ A;  1ALH A;  4MY4 A;  3NKM A;  4UOR A;  4LR8 A;  1ZED A;  1EW2 A;  1SHQ A;  4LRF A;  2W5R A;  3M8Z A;  3NVL A;  3T01 A;  1KHL A;  4ZGA A;  3KD8 A;  1ZEF A;  4LRB A;  3UN5 A;  4LRA A;  2GLQ A;  1N2L A;  4YR1 A;  2GA3 A;  2G9Y A;  2QZU A;  2IUC B;  1AJA A;  1AJB A;  1ZEB A;  1HDH A;  3CMR A;  3IGZ B;  1B8J A;  4B56 A;  4UOO A;  1ANJ A;  5DLT A;  3WBH A;  3ED4 A;  2GSU A;  2W5X A;  1E3C P;  2XR9 A;  3UO0 A;  3BDG B;  4UPH A;  5C66 A;  4ZG6 A;  1ELZ A;  3A52 A;  2IUC A;  3UNY A;  4LRE A;  5TJ3 A;  2GSO A;  4GTW A;  4LRD A;  1KHJ A;  3M7V A;  5INH A;  5DLV A;  5GRR A;  1ELX A;  4N7T A;  2X98 A;  3NKR A;  3UN3 A;  4CXK A;  1ALJ A;  4GTX A;  4KJD A;  5LIA A;  2ANH A;  3BDF A;  3MK0 A;  3WAV A;  3WAW A;  1ALI A;  4UPI A;  4GTY A;  2W5W A;  1AUK A;  3NKO A;  2GSN A;  1ELY A;  3UN2 A;  3M8Y A;  1KHN A;  1O98 A;  5EGE A;  5L0K A;  2D1G A;  4NWX A;  4GTZ A;  5IJS A;  4LR9 A;  1SHN A;  1AJD A;  1N2K A;  4ZG7 A;  5EGH A;  3MK1 A;  2W8D A;  5DLW A;  1HQA A;  3TWZ A;  4FDJ A;  3TG0 A;  4LQY A;  1EI6 A;  1KH9 A;  1EW9 A;  1URA A;  4FDI A;  3DPC A;  4LRC A;  3WAY A;  3E2D A;  1EJJ A;  1KH4 A;  1E33 P;  4MIV A;  1Y7A A;  3WAX A;  1URB A;  1E2S P;  3NKN A;  5HRT A;  1ANI A;  2XRG A;  5L0E A;  1KHK A;  5GOV A;  4KAY A;  2VQR A;  3LXQ A;  3SZZ A;  1O99 A;  1FSU A;  4KJG A;  4LR2 A;  2ZKT A;  1Y6V A;  3NKQ A;  3DYC A;  5K4P A;  1HJK A;  3MK2 A;  4MHX A;  4UPK A;  2W5Q A;  1AJC A;  5KXA A;  2W8S A;  1ED9 A;  2RH6 A;  5LRN A;  4LR7 A;  3T00 A;  5LRM A;  2W5V A;  1KH5 A;  4CYS A;  4TN0 A;  3IGY B;  2W5S A;  4NWJ A;  1ALK A;  2W5T A;  1ED8 A;  3SZY A;  5AJ9 A;  3TX0 A;  1EQJ A;  4CXU A;  4ZG9 A;  1K7H A;  3BDH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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