1EW9A

Alkaline phosphatase (e.c. 3.1.3.1) complex with mercaptomethyl phosphonate
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
total genus 159
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew9A00
4LR2A 2W8DA 1URBA 3T01A 1KH4A 2IFYA 2W5VA 2GLQA 4FDIA 2W8SA 1ANIA 1P49A 3NKNA 1KH7A 3E2DA 2W5TA 5L0BA 1B8JA 1HDHA 5IJQA 4LR8A 1EQJA 3WAXA 4LR7A 2ZKTA 1O98A 3TWZA 1SHNA 1ALIA 2W5XA 2D1GA 4GTWA 5EGHA 4LRBA 4UPIA 3CMRA 3T00A 3BDGA 1Y7AA 5LIAA 1ELYA 1EW8A 1EJJA 3TX0A 4QAXA 4UPKA 1ALJA 4KJGA 4GTYA 4CYSA 4MIVA 2W5QA 3SZZA 3M8YA 3UNYA 3WAVA 4UPLA 2GSOA 1ALKA 1EW9A 1ZEFA 4LR9A 1AJAA 1E3CP 4CXUA 1HJKA 5EGEA 4ZGAA 1ED8A 1KH5A 3WAWA 3B5QA 4FDJA 1FSUA 2W5SA 3UO0A 4CXSA 3M7VA 2XRGA 2G9YA 1ED9A 2IUCA 4GTXA 3T02A 3UN2A 5IJSA 1Y6VA 5GRRA 2GSNA 3IGYB 2W5RA 1EI6A 3Q3QA 4LRFA 4MY4A 5AJ9A 1ELZA 4NWJA 3BDFA 4KJDA 1ELXA 1KHKA 1AUKA 2VQRA 4NWXA 3WAYA 5TJ3A 4UORA 5L0EA 2QZUA 1HQAA 5C66A 3WBHA 2GSUA 4KAVA 3TG0A 2RH6A 5LRNA 3ED4A 5DLTA 5KXAA 3NKPA 1KHJA 3OT9A 1N2LA 1ALHA 4MHXA 3LXQA 3NKRA 1E33P 4UPHA 3MK0A 1O99A 4B56A 4N7TA 2W5WA 2ANHA 3NKMA 3DPCA 1SHQA 4LRDA 5L0KA 3IDDA 5DLVA 4GTZA 4LRCA 3DYCA 4UOPA 2IUCB 2XR9A 3M8ZA 1AJCA 3UN5A 4KAYA 5INHA 3KD8A 1KHLA 3BDGB 2X98A 3NKOA 1ZEDA 4KM4A 1AJDA 3MK2A 4CYRA 4ZG7A 5LRMA 3UN3A 4LQYA 4CXKA 3MK1A 1E1ZP 1KHNA 1URAA 3SZYA 5HRTA 1ANJA 1N2KA 3M8WA 3BDHA 2GA3A 5K4PA 1KH9A 4UOOA 4ZG6A 5GOVA 1EW2A 1E2SP 4LRAA 5LQQA 3A52A 5DLWA 4ZG9A 3NKQA 4YR1A 3IGZB 3NVLA 1ZEBA 1K7HA 4LREA 1AJBA 4TN0A
chains in the Genus database with same CATH superfamily
4LR2A 2W8DA 1URBA 3T01A 1KH4A 2IFYA 2W5VA 2GLQA 4FDIA 2W8SA 1ANIA 1P49A 3NKNA 1KH7A 3E2DA 2W5TA 5L0BA 1B8JA 1HDHA 5IJQA 4LR8A 1EQJA 3WAXA 4LR7A 2ZKTA 1O98A 3TWZA 1SHNA 1ALIA 2W5XA 2D1GA 4GTWA 5EGHA 4LRBA 4UPIA 3CMRA 3T00A 3BDGA 1Y7AA 5LIAA 1ELYA 1EW8A 1EJJA 3TX0A 4QAXA 4UPKA 1ALJA 4KJGA 4GTYA 4CYSA 4MIVA 2W5QA 3SZZA 3M8YA 3UNYA 3WAVA 4UPLA 2GSOA 1ALKA 1EW9A 1ZEFA 4LR9A 1AJAA 1E3CP 4CXUA 1HJKA 5EGEA 4ZGAA 1ED8A 1KH5A 3WAWA 3B5QA 4FDJA 1FSUA 2W5SA 3UO0A 4CXSA 3M7VA 2XRGA 2G9YA 1ED9A 2IUCA 4GTXA 3T02A 3UN2A 5IJSA 1Y6VA 5GRRA 2GSNA 3IGYB 2W5RA 1EI6A 3Q3QA 4LRFA 4MY4A 5AJ9A 1ELZA 4NWJA 3BDFA 4KJDA 1ELXA 1KHKA 1AUKA 2VQRA 4NWXA 3WAYA 5TJ3A 4UORA 5L0EA 2QZUA 1HQAA 5C66A 3WBHA 2GSUA 4KAVA 3TG0A 2RH6A 5LRNA 3ED4A 5DLTA 5KXAA 3NKPA 1KHJA 3OT9A 1N2LA 1ALHA 4MHXA 3LXQA 3NKRA 1E33P 4UPHA 3MK0A 1O99A 4B56A 4N7TA 2W5WA 2ANHA 3NKMA 3DPCA 1SHQA 4LRDA 5L0KA 3IDDA 5DLVA 4GTZA 4LRCA 3DYCA 4UOPA 2IUCB 2XR9A 3M8ZA 1AJCA 3UN5A 4KAYA 5INHA 3KD8A 1KHLA 3BDGB 2X98A 3NKOA 1ZEDA 4KM4A 1AJDA 3MK2A 4CYRA 4ZG7A 5LRMA 3UN3A 4LQYA 4CXKA 3MK1A 1E1ZP 1KHNA 1URAA 3SZYA 5HRTA 1ANJA 1N2KA 3M8WA 3BDHA 2GA3A 5K4PA 1KH9A 4UOOA 4ZG6A 5GOVA 1EW2A 1E2SP 4LRAA 5LQQA 3A52A 5DLWA 4ZG9A 3NKQA 4YR1A 3IGZB 3NVLA 1ZEBA 1K7HA 4LREA 1AJBA 4TN0A
chains in the Genus database with same CATH topology
4LR2A 2W8DA 1URBA 3T01A 1KH4A 2IFYA 2W5VA 2GLQA 4FDIA 2W8SA 1ANIA 1P49A 3NKNA 1KH7A 3E2DA 2W5TA 5L0BA 1B8JA 1HDHA 5IJQA 4LR8A 1EQJA 3WAXA 4LR7A 2ZKTA 1O98A 3TWZA 1SHNA 1ALIA 2W5XA 2D1GA 4GTWA 5EGHA 4LRBA 4UPIA 3CMRA 3T00A 3BDGA 1Y7AA 5LIAA 1ELYA 1EW8A 1EJJA 3TX0A 4QAXA 4UPKA 1ALJA 4KJGA 4GTYA 4CYSA 4MIVA 2W5QA 3SZZA 3M8YA 3UNYA 3WAVA 4UPLA 2GSOA 1ALKA 1EW9A 1ZEFA 4LR9A 1AJAA 1E3CP 4CXUA 1HJKA 5EGEA 4ZGAA 1ED8A 1KH5A 3WAWA 3B5QA 4FDJA 1FSUA 2W5SA 3UO0A 4CXSA 3M7VA 2XRGA 2G9YA 1ED9A 2IUCA 4GTXA 3T02A 3UN2A 5IJSA 1Y6VA 5GRRA 2GSNA 3IGYB 2W5RA 1EI6A 3Q3QA 4LRFA 4MY4A 5AJ9A 1ELZA 4NWJA 3BDFA 4KJDA 1ELXA 1KHKA 1AUKA 2VQRA 4NWXA 3WAYA 5TJ3A 4UORA 5L0EA 2QZUA 1HQAA 5C66A 3WBHA 2GSUA 4KAVA 3TG0A 2RH6A 5LRNA 3ED4A 5DLTA 5KXAA 3NKPA 1KHJA 3OT9A 1N2LA 1ALHA 4MHXA 3LXQA 3NKRA 1E33P 4UPHA 3MK0A 1O99A 4B56A 4N7TA 2W5WA 2ANHA 3NKMA 3DPCA 1SHQA 4LRDA 5L0KA 3IDDA 5DLVA 4GTZA 4LRCA 3DYCA 4UOPA 2IUCB 2XR9A 3M8ZA 1AJCA 3UN5A 4KAYA 5INHA 3KD8A 1KHLA 3BDGB 2X98A 3NKOA 1ZEDA 4KM4A 1AJDA 3MK2A 4CYRA 4ZG7A 5LRMA 3UN3A 4LQYA 4CXKA 3MK1A 1E1ZP 1KHNA 1URAA 3SZYA 5HRTA 1ANJA 1N2KA 3M8WA 3BDHA 2GA3A 5K4PA 1KH9A 4UOOA 4ZG6A 5GOVA 1EW2A 1E2SP 4LRAA 5LQQA 3A52A 5DLWA 4ZG9A 3NKQA 4YR1A 3IGZB 3NVLA 1ZEBA 1K7HA 4LREA 1AJBA 4TN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR2 A;  2W8D A;  1URB A;  3T01 A;  1KH4 A;  2IFY A;  2W5V A;  2GLQ A;  4FDI A;  2W8S A;  1ANI A;  1P49 A;  3NKN A;  1KH7 A;  3E2D A;  2W5T A;  5L0B A;  1B8J A;  1HDH A;  5IJQ A;  4LR8 A;  1EQJ A;  3WAX A;  4LR7 A;  2ZKT A;  1O98 A;  3TWZ A;  1SHN A;  1ALI A;  2W5X A;  2D1G A;  4GTW A;  5EGH A;  4LRB A;  4UPI A;  3CMR A;  3T00 A;  3BDG A;  1Y7A A;  5LIA A;  1ELY A;  1EW8 A;  1EJJ A;  3TX0 A;  4QAX A;  4UPK A;  1ALJ A;  4KJG A;  4GTY A;  4CYS A;  4MIV A;  2W5Q A;  3SZZ A;  3M8Y A;  3UNY A;  3WAV A;  4UPL A;  2GSO A;  1ALK A;  1EW9 A;  1ZEF A;  4LR9 A;  1AJA A;  1E3C P;  4CXU A;  1HJK A;  5EGE A;  4ZGA A;  1ED8 A;  1KH5 A;  3WAW A;  3B5Q A;  4FDJ A;  1FSU A;  2W5S A;  3UO0 A;  4CXS A;  3M7V A;  2XRG A;  2G9Y A;  1ED9 A;  2IUC A;  4GTX A;  3T02 A;  3UN2 A;  5IJS A;  1Y6V A;  5GRR A;  2GSN A;  3IGY B;  2W5R A;  1EI6 A;  3Q3Q A;  4LRF A;  4MY4 A;  5AJ9 A;  1ELZ A;  4NWJ A;  3BDF A;  4KJD A;  1ELX A;  1KHK A;  1AUK A;  2VQR A;  4NWX A;  3WAY A;  5TJ3 A;  4UOR A;  5L0E A;  2QZU A;  1HQA A;  5C66 A;  3WBH A;  2GSU A;  4KAV A;  3TG0 A;  2RH6 A;  5LRN A;  3ED4 A;  5DLT A;  5KXA A;  3NKP A;  1KHJ A;  3OT9 A;  1N2L A;  1ALH A;  4MHX A;  3LXQ A;  3NKR A;  1E33 P;  4UPH A;  3MK0 A;  1O99 A;  4B56 A;  4N7T A;  2W5W A;  2ANH A;  3NKM A;  3DPC A;  1SHQ A;  4LRD A;  5L0K A;  3IDD A;  5DLV A;  4GTZ A;  4LRC A;  3DYC A;  4UOP A;  2IUC B;  2XR9 A;  3M8Z A;  1AJC A;  3UN5 A;  4KAY A;  5INH A;  3KD8 A;  1KHL A;  3BDG B;  2X98 A;  3NKO A;  1ZED A;  4KM4 A;  1AJD A;  3MK2 A;  4CYR A;  4ZG7 A;  5LRM A;  3UN3 A;  4LQY A;  4CXK A;  3MK1 A;  1E1Z P;  1KHN A;  1URA A;  3SZY A;  5HRT A;  1ANJ A;  1N2K A;  3M8W A;  3BDH A;  2GA3 A;  5K4P A;  1KH9 A;  4UOO A;  4ZG6 A;  5GOV A;  1EW2 A;  1E2S P;  4LRA A;  5LQQ A;  3A52 A;  5DLW A;  4ZG9 A;  3NKQ A;  4YR1 A;  3IGZ B;  3NVL A;  1ZEB A;  1K7H A;  4LRE A;  1AJB A;  4TN0 A; 
#chains in the Genus database with same CATH topology
 4LR2 A;  2W8D A;  1URB A;  3T01 A;  1KH4 A;  2IFY A;  2W5V A;  2GLQ A;  4FDI A;  2W8S A;  1ANI A;  1P49 A;  3NKN A;  1KH7 A;  3E2D A;  2W5T A;  5L0B A;  1B8J A;  1HDH A;  5IJQ A;  4LR8 A;  1EQJ A;  3WAX A;  4LR7 A;  2ZKT A;  1O98 A;  3TWZ A;  1SHN A;  1ALI A;  2W5X A;  2D1G A;  4GTW A;  5EGH A;  4LRB A;  4UPI A;  3CMR A;  3T00 A;  3BDG A;  1Y7A A;  5LIA A;  1ELY A;  1EW8 A;  1EJJ A;  3TX0 A;  4QAX A;  4UPK A;  1ALJ A;  4KJG A;  4GTY A;  4CYS A;  4MIV A;  2W5Q A;  3SZZ A;  3M8Y A;  3UNY A;  3WAV A;  4UPL A;  2GSO A;  1ALK A;  1EW9 A;  1ZEF A;  4LR9 A;  1AJA A;  1E3C P;  4CXU A;  1HJK A;  5EGE A;  4ZGA A;  1ED8 A;  1KH5 A;  3WAW A;  3B5Q A;  4FDJ A;  1FSU A;  2W5S A;  3UO0 A;  4CXS A;  3M7V A;  2XRG A;  2G9Y A;  1ED9 A;  2IUC A;  4GTX A;  3T02 A;  3UN2 A;  5IJS A;  1Y6V A;  5GRR A;  2GSN A;  3IGY B;  2W5R A;  1EI6 A;  3Q3Q A;  4LRF A;  4MY4 A;  5AJ9 A;  1ELZ A;  4NWJ A;  3BDF A;  4KJD A;  1ELX A;  1KHK A;  1AUK A;  2VQR A;  4NWX A;  3WAY A;  5TJ3 A;  4UOR A;  5L0E A;  2QZU A;  1HQA A;  5C66 A;  3WBH A;  2GSU A;  4KAV A;  3TG0 A;  2RH6 A;  5LRN A;  3ED4 A;  5DLT A;  5KXA A;  3NKP A;  1KHJ A;  3OT9 A;  1N2L A;  1ALH A;  4MHX A;  3LXQ A;  3NKR A;  1E33 P;  4UPH A;  3MK0 A;  1O99 A;  4B56 A;  4N7T A;  2W5W A;  2ANH A;  3NKM A;  3DPC A;  1SHQ A;  4LRD A;  5L0K A;  3IDD A;  5DLV A;  4GTZ A;  4LRC A;  3DYC A;  4UOP A;  2IUC B;  2XR9 A;  3M8Z A;  1AJC A;  3UN5 A;  4KAY A;  5INH A;  3KD8 A;  1KHL A;  3BDG B;  2X98 A;  3NKO A;  1ZED A;  4KM4 A;  1AJD A;  3MK2 A;  4CYR A;  4ZG7 A;  5LRM A;  3UN3 A;  4LQY A;  4CXK A;  3MK1 A;  1E1Z P;  1KHN A;  1URA A;  3SZY A;  5HRT A;  1ANJ A;  1N2K A;  3M8W A;  3BDH A;  2GA3 A;  5K4P A;  1KH9 A;  4UOO A;  4ZG6 A;  5GOV A;  1EW2 A;  1E2S P;  4LRA A;  5LQQ A;  3A52 A;  5DLW A;  4ZG9 A;  3NKQ A;  4YR1 A;  3IGZ B;  3NVL A;  1ZEB A;  1K7H A;  4LRE A;  1AJB A;  4TN0 A; 
#chains in the Genus database with same CATH homology
 4LR2 A;  2W8D A;  1URB A;  3T01 A;  1KH4 A;  2IFY A;  2W5V A;  2GLQ A;  4FDI A;  2W8S A;  1ANI A;  1P49 A;  3NKN A;  1KH7 A;  3E2D A;  2W5T A;  5L0B A;  1B8J A;  1HDH A;  5IJQ A;  4LR8 A;  1EQJ A;  3WAX A;  4LR7 A;  2ZKT A;  1O98 A;  3TWZ A;  1SHN A;  1ALI A;  2W5X A;  2D1G A;  4GTW A;  5EGH A;  4LRB A;  4UPI A;  3CMR A;  3T00 A;  3BDG A;  1Y7A A;  5LIA A;  1ELY A;  1EW8 A;  1EJJ A;  3TX0 A;  4QAX A;  4UPK A;  1ALJ A;  4KJG A;  4GTY A;  4CYS A;  4MIV A;  2W5Q A;  3SZZ A;  3M8Y A;  3UNY A;  3WAV A;  4UPL A;  2GSO A;  1ALK A;  1EW9 A;  1ZEF A;  4LR9 A;  1AJA A;  1E3C P;  4CXU A;  1HJK A;  5EGE A;  4ZGA A;  1ED8 A;  1KH5 A;  3WAW A;  3B5Q A;  4FDJ A;  1FSU A;  2W5S A;  3UO0 A;  4CXS A;  3M7V A;  2XRG A;  2G9Y A;  1ED9 A;  2IUC A;  4GTX A;  3T02 A;  3UN2 A;  5IJS A;  1Y6V A;  5GRR A;  2GSN A;  3IGY B;  2W5R A;  1EI6 A;  3Q3Q A;  4LRF A;  4MY4 A;  5AJ9 A;  1ELZ A;  4NWJ A;  3BDF A;  4KJD A;  1ELX A;  1KHK A;  1AUK A;  2VQR A;  4NWX A;  3WAY A;  5TJ3 A;  4UOR A;  5L0E A;  2QZU A;  1HQA A;  5C66 A;  3WBH A;  2GSU A;  4KAV A;  3TG0 A;  2RH6 A;  5LRN A;  3ED4 A;  5DLT A;  5KXA A;  3NKP A;  1KHJ A;  3OT9 A;  1N2L A;  1ALH A;  4MHX A;  3LXQ A;  3NKR A;  1E33 P;  4UPH A;  3MK0 A;  1O99 A;  4B56 A;  4N7T A;  2W5W A;  2ANH A;  3NKM A;  3DPC A;  1SHQ A;  4LRD A;  5L0K A;  3IDD A;  5DLV A;  4GTZ A;  4LRC A;  3DYC A;  4UOP A;  2IUC B;  2XR9 A;  3M8Z A;  1AJC A;  3UN5 A;  4KAY A;  5INH A;  3KD8 A;  1KHL A;  3BDG B;  2X98 A;  3NKO A;  1ZED A;  4KM4 A;  1AJD A;  3MK2 A;  4CYR A;  4ZG7 A;  5LRM A;  3UN3 A;  4LQY A;  4CXK A;  3MK1 A;  1E1Z P;  1KHN A;  1URA A;  3SZY A;  5HRT A;  1ANJ A;  1N2K A;  3M8W A;  3BDH A;  2GA3 A;  5K4P A;  1KH9 A;  4UOO A;  4ZG6 A;  5GOV A;  1EW2 A;  1E2S P;  4LRA A;  5LQQ A;  3A52 A;  5DLW A;  4ZG9 A;  3NKQ A;  4YR1 A;  3IGZ B;  3NVL A;  1ZEB A;  1K7H A;  4LRE A;  1AJB A;  4TN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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