1EW9A

Alkaline phosphatase (e.c. 3.1.3.1) complex with mercaptomethyl phosphonate
Total Genus 159
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
159
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes.
pubmed rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 159
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew9A00
4UPIA 3LXQA 4UPHA 2W5TA 4CYRA 1O98A 3M8ZA 4UOOA 3ED4A 1K7HA 3WAVA 4FDIA 3BDGA 4FDJA 1SHQA 3NKRA 4NWJA 1EI6A 3NKNA 1HJKA 4KJDA 1SHNA 2GSUA 2D1GA 4UPLA 5KXAA 4QAXA 1N2KA 1ANJA 4NWXA 3WBHA 2XRGA 1KH9A 1ALJA 1AJBA 1AJCA 4ZGAA 4LR8A 5HRTA 4KJGA 3T01A 1KH4A 1ZEDA 3IGZB 2GLQA 3MK2A 4LRAA 2GSNA 4ZG7A 3A52A 1EW2A 2ZKTA 1ELXA 1Y6VA 3SZZA 5C66A 3TG0A 5GRRA 1AJAA 3TWZA 1EJJA 5L0EA 1ZEFA 2RH6A 3BDGB 1E33P 4KAYA 3WAYA 3IDDA 2W5RA 5IJSA 4LRFA 1KH5A 4GTWA 4YR1A 5LRNA 2GA3A 2IFYA 5LIAA 2QZUA 3UN2A 1ALIA 1ELYA 3M8WA 3BDFA 1KHKA 4GTXA 2W5SA 4GTZA 3NKMA 3TX0A 5LRMA 4MIVA 3E2DA 2W8SA 4CXKA 3IGYB 2IUCA 2IUCB 4LR9A 3CMRA 3NKOA 1P49A 1O99A 4LRBA 3T00A 5INHA 5TJ3A 3M7VA 4CXUA 1EQJA 1E3CP 3DYCA 4GTYA 1EW8A 2W8DA 3UN3A 3NVLA 5DLTA 1Y7AA 4B56A 5EGHA 2W5VA 1E2SP 2XR9A 3WAWA 3M8YA 3NKPA 3Q3QA 3BDHA 2W5WA 3MK0A 5DLWA 2X98A 1N2LA 4LRDA 5DLVA 2ANHA 3DPCA 1URBA 1B8JA 1HDHA 2W5QA 3SZYA 1ZEBA 4UOPA 3UO0A 3NKQA 3UNYA 5L0KA 1ANIA 5AJ9A 1ED8A 2G9YA 4ZG6A 4KM4A 1ALKA 4UPKA 4LR2A 5EGEA 4MHXA 4KAVA 4LR7A 4CXSA 1E1ZP 3B5QA 1FSUA 2GSOA 3OT9A 1ALHA 4TN0A 1KHLA 5K4PA 4MY4A 1KHJA 1ELZA 1KHNA 1AUKA 1AJDA 1ED9A 2VQRA 2W5XA 3T02A 1KH7A 4N7TA 3WAXA 3UN5A 1EW9A 4LREA 1HQAA 5LQQA 3KD8A 1URAA 5L0BA 4LRCA 4LQYA 5GOVA 4CYSA 4UORA 5IJQA 4ZG9A 3MK1A
chains in the Genus database with same CATH superfamily
4UPIA 3LXQA 4UPHA 2W5TA 4CYRA 1O98A 3M8ZA 4UOOA 3ED4A 1K7HA 3WAVA 4FDIA 3BDGA 4FDJA 1SHQA 3NKRA 4NWJA 1EI6A 3NKNA 1HJKA 4KJDA 1SHNA 2GSUA 2D1GA 4UPLA 5KXAA 4QAXA 1N2KA 1ANJA 4NWXA 3WBHA 2XRGA 1KH9A 1ALJA 1AJBA 1AJCA 4ZGAA 4LR8A 5HRTA 4KJGA 3T01A 1KH4A 1ZEDA 3IGZB 2GLQA 3MK2A 4LRAA 2GSNA 4ZG7A 3A52A 1EW2A 2ZKTA 1ELXA 1Y6VA 3SZZA 5C66A 3TG0A 5GRRA 1AJAA 3TWZA 1EJJA 5L0EA 1ZEFA 2RH6A 3BDGB 1E33P 4KAYA 3WAYA 3IDDA 2W5RA 5IJSA 4LRFA 1KH5A 4GTWA 4YR1A 5LRNA 2GA3A 2IFYA 5LIAA 2QZUA 3UN2A 1ALIA 1ELYA 3M8WA 3BDFA 1KHKA 4GTXA 2W5SA 4GTZA 3NKMA 3TX0A 5LRMA 4MIVA 3E2DA 2W8SA 4CXKA 3IGYB 2IUCA 2IUCB 4LR9A 3CMRA 3NKOA 1P49A 1O99A 4LRBA 3T00A 5INHA 5TJ3A 3M7VA 4CXUA 1EQJA 1E3CP 3DYCA 4GTYA 1EW8A 2W8DA 3UN3A 3NVLA 5DLTA 1Y7AA 4B56A 5EGHA 2W5VA 1E2SP 2XR9A 3WAWA 3M8YA 3NKPA 3Q3QA 3BDHA 2W5WA 3MK0A 5DLWA 2X98A 1N2LA 4LRDA 5DLVA 2ANHA 3DPCA 1URBA 1B8JA 1HDHA 2W5QA 3SZYA 1ZEBA 4UOPA 3UO0A 3NKQA 3UNYA 5L0KA 1ANIA 5AJ9A 1ED8A 2G9YA 4ZG6A 4KM4A 1ALKA 4UPKA 4LR2A 5EGEA 4MHXA 4KAVA 4LR7A 4CXSA 1E1ZP 3B5QA 1FSUA 2GSOA 3OT9A 1ALHA 4TN0A 1KHLA 5K4PA 4MY4A 1KHJA 1ELZA 1KHNA 1AUKA 1AJDA 1ED9A 2VQRA 2W5XA 3T02A 1KH7A 4N7TA 3WAXA 3UN5A 1EW9A 4LREA 1HQAA 5LQQA 3KD8A 1URAA 5L0BA 4LRCA 4LQYA 5GOVA 4CYSA 4UORA 5IJQA 4ZG9A 3MK1A
chains in the Genus database with same CATH topology
4UPIA 3LXQA 4UPHA 2W5TA 4CYRA 1O98A 3M8ZA 4UOOA 3ED4A 1K7HA 3WAVA 4FDIA 3BDGA 4FDJA 1SHQA 3NKRA 4NWJA 1EI6A 3NKNA 1HJKA 4KJDA 1SHNA 2GSUA 2D1GA 4UPLA 5KXAA 4QAXA 1N2KA 1ANJA 4NWXA 3WBHA 2XRGA 1KH9A 1ALJA 1AJBA 1AJCA 4ZGAA 4LR8A 5HRTA 4KJGA 3T01A 1KH4A 1ZEDA 3IGZB 2GLQA 3MK2A 4LRAA 2GSNA 4ZG7A 3A52A 1EW2A 2ZKTA 1ELXA 1Y6VA 3SZZA 5C66A 3TG0A 5GRRA 1AJAA 3TWZA 1EJJA 5L0EA 1ZEFA 2RH6A 3BDGB 1E33P 4KAYA 3WAYA 3IDDA 2W5RA 5IJSA 4LRFA 1KH5A 4GTWA 4YR1A 5LRNA 2GA3A 2IFYA 5LIAA 2QZUA 3UN2A 1ALIA 1ELYA 3M8WA 3BDFA 1KHKA 4GTXA 2W5SA 4GTZA 3NKMA 3TX0A 5LRMA 4MIVA 3E2DA 2W8SA 4CXKA 3IGYB 2IUCA 2IUCB 4LR9A 3CMRA 3NKOA 1P49A 1O99A 4LRBA 3T00A 5INHA 5TJ3A 3M7VA 4CXUA 1EQJA 1E3CP 3DYCA 4GTYA 1EW8A 2W8DA 3UN3A 3NVLA 5DLTA 1Y7AA 4B56A 5EGHA 2W5VA 1E2SP 2XR9A 3WAWA 3M8YA 3NKPA 3Q3QA 3BDHA 2W5WA 3MK0A 5DLWA 2X98A 1N2LA 4LRDA 5DLVA 2ANHA 3DPCA 1URBA 1B8JA 1HDHA 2W5QA 3SZYA 1ZEBA 4UOPA 3UO0A 3NKQA 3UNYA 5L0KA 1ANIA 5AJ9A 1ED8A 2G9YA 4ZG6A 4KM4A 1ALKA 4UPKA 4LR2A 5EGEA 4MHXA 4KAVA 4LR7A 4CXSA 1E1ZP 3B5QA 1FSUA 2GSOA 3OT9A 1ALHA 4TN0A 1KHLA 5K4PA 4MY4A 1KHJA 1ELZA 1KHNA 1AUKA 1AJDA 1ED9A 2VQRA 2W5XA 3T02A 1KH7A 4N7TA 3WAXA 3UN5A 1EW9A 4LREA 1HQAA 5LQQA 3KD8A 1URAA 5L0BA 4LRCA 4LQYA 5GOVA 4CYSA 4UORA 5IJQA 4ZG9A 3MK1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UPI A;  3LXQ A;  4UPH A;  2W5T A;  4CYR A;  1O98 A;  3M8Z A;  4UOO A;  3ED4 A;  1K7H A;  3WAV A;  4FDI A;  3BDG A;  4FDJ A;  1SHQ A;  3NKR A;  4NWJ A;  1EI6 A;  3NKN A;  1HJK A;  4KJD A;  1SHN A;  2GSU A;  2D1G A;  4UPL A;  5KXA A;  4QAX A;  1N2K A;  1ANJ A;  4NWX A;  3WBH A;  2XRG A;  1KH9 A;  1ALJ A;  1AJB A;  1AJC A;  4ZGA A;  4LR8 A;  5HRT A;  4KJG A;  3T01 A;  1KH4 A;  1ZED A;  3IGZ B;  2GLQ A;  3MK2 A;  4LRA A;  2GSN A;  4ZG7 A;  3A52 A;  1EW2 A;  2ZKT A;  1ELX A;  1Y6V A;  3SZZ A;  5C66 A;  3TG0 A;  5GRR A;  1AJA A;  3TWZ A;  1EJJ A;  5L0E A;  1ZEF A;  2RH6 A;  3BDG B;  1E33 P;  4KAY A;  3WAY A;  3IDD A;  2W5R A;  5IJS A;  4LRF A;  1KH5 A;  4GTW A;  4YR1 A;  5LRN A;  2GA3 A;  2IFY A;  5LIA A;  2QZU A;  3UN2 A;  1ALI A;  1ELY A;  3M8W A;  3BDF A;  1KHK A;  4GTX A;  2W5S A;  4GTZ A;  3NKM A;  3TX0 A;  5LRM A;  4MIV A;  3E2D A;  2W8S A;  4CXK A;  3IGY B;  2IUC A;  2IUC B;  4LR9 A;  3CMR A;  3NKO A;  1P49 A;  1O99 A;  4LRB A;  3T00 A;  5INH A;  5TJ3 A;  3M7V A;  4CXU A;  1EQJ A;  1E3C P;  3DYC A;  4GTY A;  1EW8 A;  2W8D A;  3UN3 A;  3NVL A;  5DLT A;  1Y7A A;  4B56 A;  5EGH A;  2W5V A;  1E2S P;  2XR9 A;  3WAW A;  3M8Y A;  3NKP A;  3Q3Q A;  3BDH A;  2W5W A;  3MK0 A;  5DLW A;  2X98 A;  1N2L A;  4LRD A;  5DLV A;  2ANH A;  3DPC A;  1URB A;  1B8J A;  1HDH A;  2W5Q A;  3SZY A;  1ZEB A;  4UOP A;  3UO0 A;  3NKQ A;  3UNY A;  5L0K A;  1ANI A;  5AJ9 A;  1ED8 A;  2G9Y A;  4ZG6 A;  4KM4 A;  1ALK A;  4UPK A;  4LR2 A;  5EGE A;  4MHX A;  4KAV A;  4LR7 A;  4CXS A;  1E1Z P;  3B5Q A;  1FSU A;  2GSO A;  3OT9 A;  1ALH A;  4TN0 A;  1KHL A;  5K4P A;  4MY4 A;  1KHJ A;  1ELZ A;  1KHN A;  1AUK A;  1AJD A;  1ED9 A;  2VQR A;  2W5X A;  3T02 A;  1KH7 A;  4N7T A;  3WAX A;  3UN5 A;  1EW9 A;  4LRE A;  1HQA A;  5LQQ A;  3KD8 A;  1URA A;  5L0B A;  4LRC A;  4LQY A;  5GOV A;  4CYS A;  4UOR A;  5IJQ A;  4ZG9 A;  3MK1 A; 
#chains in the Genus database with same CATH topology
 4UPI A;  3LXQ A;  4UPH A;  2W5T A;  4CYR A;  1O98 A;  3M8Z A;  4UOO A;  3ED4 A;  1K7H A;  3WAV A;  4FDI A;  3BDG A;  4FDJ A;  1SHQ A;  3NKR A;  4NWJ A;  1EI6 A;  3NKN A;  1HJK A;  4KJD A;  1SHN A;  2GSU A;  2D1G A;  4UPL A;  5KXA A;  4QAX A;  1N2K A;  1ANJ A;  4NWX A;  3WBH A;  2XRG A;  1KH9 A;  1ALJ A;  1AJB A;  1AJC A;  4ZGA A;  4LR8 A;  5HRT A;  4KJG A;  3T01 A;  1KH4 A;  1ZED A;  3IGZ B;  2GLQ A;  3MK2 A;  4LRA A;  2GSN A;  4ZG7 A;  3A52 A;  1EW2 A;  2ZKT A;  1ELX A;  1Y6V A;  3SZZ A;  5C66 A;  3TG0 A;  5GRR A;  1AJA A;  3TWZ A;  1EJJ A;  5L0E A;  1ZEF A;  2RH6 A;  3BDG B;  1E33 P;  4KAY A;  3WAY A;  3IDD A;  2W5R A;  5IJS A;  4LRF A;  1KH5 A;  4GTW A;  4YR1 A;  5LRN A;  2GA3 A;  2IFY A;  5LIA A;  2QZU A;  3UN2 A;  1ALI A;  1ELY A;  3M8W A;  3BDF A;  1KHK A;  4GTX A;  2W5S A;  4GTZ A;  3NKM A;  3TX0 A;  5LRM A;  4MIV A;  3E2D A;  2W8S A;  4CXK A;  3IGY B;  2IUC A;  2IUC B;  4LR9 A;  3CMR A;  3NKO A;  1P49 A;  1O99 A;  4LRB A;  3T00 A;  5INH A;  5TJ3 A;  3M7V A;  4CXU A;  1EQJ A;  1E3C P;  3DYC A;  4GTY A;  1EW8 A;  2W8D A;  3UN3 A;  3NVL A;  5DLT A;  1Y7A A;  4B56 A;  5EGH A;  2W5V A;  1E2S P;  2XR9 A;  3WAW A;  3M8Y A;  3NKP A;  3Q3Q A;  3BDH A;  2W5W A;  3MK0 A;  5DLW A;  2X98 A;  1N2L A;  4LRD A;  5DLV A;  2ANH A;  3DPC A;  1URB A;  1B8J A;  1HDH A;  2W5Q A;  3SZY A;  1ZEB A;  4UOP A;  3UO0 A;  3NKQ A;  3UNY A;  5L0K A;  1ANI A;  5AJ9 A;  1ED8 A;  2G9Y A;  4ZG6 A;  4KM4 A;  1ALK A;  4UPK A;  4LR2 A;  5EGE A;  4MHX A;  4KAV A;  4LR7 A;  4CXS A;  1E1Z P;  3B5Q A;  1FSU A;  2GSO A;  3OT9 A;  1ALH A;  4TN0 A;  1KHL A;  5K4P A;  4MY4 A;  1KHJ A;  1ELZ A;  1KHN A;  1AUK A;  1AJD A;  1ED9 A;  2VQR A;  2W5X A;  3T02 A;  1KH7 A;  4N7T A;  3WAX A;  3UN5 A;  1EW9 A;  4LRE A;  1HQA A;  5LQQ A;  3KD8 A;  1URA A;  5L0B A;  4LRC A;  4LQY A;  5GOV A;  4CYS A;  4UOR A;  5IJQ A;  4ZG9 A;  3MK1 A; 
#chains in the Genus database with same CATH homology
 4UPI A;  3LXQ A;  4UPH A;  2W5T A;  4CYR A;  1O98 A;  3M8Z A;  4UOO A;  3ED4 A;  1K7H A;  3WAV A;  4FDI A;  3BDG A;  4FDJ A;  1SHQ A;  3NKR A;  4NWJ A;  1EI6 A;  3NKN A;  1HJK A;  4KJD A;  1SHN A;  2GSU A;  2D1G A;  4UPL A;  5KXA A;  4QAX A;  1N2K A;  1ANJ A;  4NWX A;  3WBH A;  2XRG A;  1KH9 A;  1ALJ A;  1AJB A;  1AJC A;  4ZGA A;  4LR8 A;  5HRT A;  4KJG A;  3T01 A;  1KH4 A;  1ZED A;  3IGZ B;  2GLQ A;  3MK2 A;  4LRA A;  2GSN A;  4ZG7 A;  3A52 A;  1EW2 A;  2ZKT A;  1ELX A;  1Y6V A;  3SZZ A;  5C66 A;  3TG0 A;  5GRR A;  1AJA A;  3TWZ A;  1EJJ A;  5L0E A;  1ZEF A;  2RH6 A;  3BDG B;  1E33 P;  4KAY A;  3WAY A;  3IDD A;  2W5R A;  5IJS A;  4LRF A;  1KH5 A;  4GTW A;  4YR1 A;  5LRN A;  2GA3 A;  2IFY A;  5LIA A;  2QZU A;  3UN2 A;  1ALI A;  1ELY A;  3M8W A;  3BDF A;  1KHK A;  4GTX A;  2W5S A;  4GTZ A;  3NKM A;  3TX0 A;  5LRM A;  4MIV A;  3E2D A;  2W8S A;  4CXK A;  3IGY B;  2IUC A;  2IUC B;  4LR9 A;  3CMR A;  3NKO A;  1P49 A;  1O99 A;  4LRB A;  3T00 A;  5INH A;  5TJ3 A;  3M7V A;  4CXU A;  1EQJ A;  1E3C P;  3DYC A;  4GTY A;  1EW8 A;  2W8D A;  3UN3 A;  3NVL A;  5DLT A;  1Y7A A;  4B56 A;  5EGH A;  2W5V A;  1E2S P;  2XR9 A;  3WAW A;  3M8Y A;  3NKP A;  3Q3Q A;  3BDH A;  2W5W A;  3MK0 A;  5DLW A;  2X98 A;  1N2L A;  4LRD A;  5DLV A;  2ANH A;  3DPC A;  1URB A;  1B8J A;  1HDH A;  2W5Q A;  3SZY A;  1ZEB A;  4UOP A;  3UO0 A;  3NKQ A;  3UNY A;  5L0K A;  1ANI A;  5AJ9 A;  1ED8 A;  2G9Y A;  4ZG6 A;  4KM4 A;  1ALK A;  4UPK A;  4LR2 A;  5EGE A;  4MHX A;  4KAV A;  4LR7 A;  4CXS A;  1E1Z P;  3B5Q A;  1FSU A;  2GSO A;  3OT9 A;  1ALH A;  4TN0 A;  1KHL A;  5K4P A;  4MY4 A;  1KHJ A;  1ELZ A;  1KHN A;  1AUK A;  1AJD A;  1ED9 A;  2VQR A;  2W5X A;  3T02 A;  1KH7 A;  4N7T A;  3WAX A;  3UN5 A;  1EW9 A;  4LRE A;  1HQA A;  5LQQ A;  3KD8 A;  1URA A;  5L0B A;  4LRC A;  4LQY A;  5GOV A;  4CYS A;  4UOR A;  5IJQ A;  4ZG9 A;  3MK1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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