1SHNA

Crystal structure of shrimp alkaline phosphatase with phosphate bound
Total Genus 187
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
187
Knots found
sequence length
476
structure length
476
Chain Sequence
EEDKAYWNKDAQDALDKQLGIKLREKQAKNVIFFLGDGMSLSTVTAARIYKGGLTGKFEREKISWEEFDFAALSKTYNTDKQVTDSAASATAYLTGVKTNQGVIGLDANTVRTNCSYQLDESLFTYSIAHWFQEAGRSTGVVTSTRVTHATPAGTYAHVADRDWENDSDVVHDREDPEICDDIAEQLVFREPGKNFKVIMGGGRRGFFPEEALDIEDGIPGEREDGKHLITDWLDDKASQGATASYVWNRDDLLAVDIRNTDYLMGLFSYTHLDTVLTRDAEMDPTLPEMTKVAIEMLTKDENGFFLLVEGGRIDHMHHANQIRQSLAETLDMEEAVSMALSMTDPEETIILVTADHGHTLTITGYADRNTDILDFAGISDLDDRRYTILDYGSGPGYHITEDGKRYEPTEEDLKDINFRYASAAPKHSVTHDGTDVGIWVNGPFAHLFTGVYEENYIPHALAYAACVGTGRTFCD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords alkaline phosphatase
publication title Ligand-binding and metal-exchange crystallographic studies on shrimp alkaline phosphatase.
pubmed doi rcsb
total genus 187
structure length 476
sequence length 476
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2004-02-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1shnA00
4LR9A 3B5QA 4LR8A 1ED9A 3A52A 5L0BA 3UN2A 1ZEBA 1Y7AA 3TWZA 1HDHA 4ZGAA 4LRDA 4KAYA 5INHA 1EW8A 1SHQA 2GSOA 1URBA 2D1GA 2GSUA 3M8YA 3M8WA 1O98A 3MK2A 1KHNA 4LR2A 1HJKA 2G9YA 3E2DA 3M7VA 3NVLA 3Q3QA 5LRNA 2GSNA 3DPCA 4GTXA 1ANJA 3UNYA 1AJDA 1AJCA 3WAYA 5GRRA 2W5SA 3WBHA 4CXKA 3WAVA 5KXAA 4LRBA 5LRMA 4KJDA 1ELZA 2W8SA 4LRCA 4ZG6A 1HQAA 4N7TA 5L0KA 3BDGB 1AJAA 1Y6VA 3M8ZA 3BDFA 5EGEA 1AJBA 1E1ZP 2GA3A 5C66A 3UN5A 1ALKA 2IFYA 4FDJA 2IUCA 3NKMA 4UORA 1N2LA 1KH7A 4UOOA 5EGHA 1KHLA 1ALJA 1K7HA 1KHKA 4YR1A 2RH6A 4MIVA 1AUKA 3DYCA 4CXSA 5LIAA 4MY4A 3OT9A 5IJSA 4GTYA 4ZG9A 1ED8A 3WAXA 2W5TA 1EQJA 4UOPA 5HRTA 1ZEDA 1B8JA 2XR9A 2W5RA 3IDDA 3TG0A 1ZEFA 2XRGA 4ZG7A 4CXUA 1E3CP 3MK0A 5DLWA 2X98A 5GOVA 3T02A 1ALHA 3ED4A 4LRFA 3KD8A 3BDHA 3UN3A 4KAVA 4KJGA 2W5XA 3NKQA 5LQQA 3NKOA 1FSUA 5K4PA 3WAWA 1EJJA 4LREA 4UPHA 4UPKA 4MHXA 1ANIA 2QZUA 1KH5A 3BDGA 2GLQA 2W5WA 1P49A 1ALIA 1E33P 4KM4A 3IGYB 4UPIA 4LQYA 4UPLA 2W5QA 1N2KA 1EW2A 1KHJA 2W5VA 2ZKTA 4TN0A 3T00A 4CYRA 1URAA 5AJ9A 1ELYA 5DLVA 1E2SP 5IJQA 1EI6A 3SZYA 5DLTA 5L0EA 4NWJA 1KH9A 3CMRA 4CYSA 4GTWA 3NKNA 3T01A 1ELXA 4LRAA 4NWXA 2ANHA 3UO0A 1EW9A 3MK1A 2IUCB 5TJ3A 3SZZA 4B56A 3TX0A 1SHNA 3LXQA 1KH4A 1O99A 3NKRA 3NKPA 2VQRA 4GTZA 4QAXA 3IGZB 4LR7A 2W8DA 4FDIA
chains in the Genus database with same CATH superfamily
4LR9A 3B5QA 4LR8A 1ED9A 3A52A 5L0BA 3UN2A 1ZEBA 1Y7AA 3TWZA 1HDHA 4ZGAA 4LRDA 4KAYA 5INHA 1EW8A 1SHQA 2GSOA 1URBA 2D1GA 2GSUA 3M8YA 3M8WA 1O98A 3MK2A 1KHNA 4LR2A 1HJKA 2G9YA 3E2DA 3M7VA 3NVLA 3Q3QA 5LRNA 2GSNA 3DPCA 4GTXA 1ANJA 3UNYA 1AJDA 1AJCA 3WAYA 5GRRA 2W5SA 3WBHA 4CXKA 3WAVA 5KXAA 4LRBA 5LRMA 4KJDA 1ELZA 2W8SA 4LRCA 4ZG6A 1HQAA 4N7TA 5L0KA 3BDGB 1AJAA 1Y6VA 3M8ZA 3BDFA 5EGEA 1AJBA 1E1ZP 2GA3A 5C66A 3UN5A 1ALKA 2IFYA 4FDJA 2IUCA 3NKMA 4UORA 1N2LA 1KH7A 4UOOA 5EGHA 1KHLA 1ALJA 1K7HA 1KHKA 4YR1A 2RH6A 4MIVA 1AUKA 3DYCA 4CXSA 5LIAA 4MY4A 3OT9A 5IJSA 4GTYA 4ZG9A 1ED8A 3WAXA 2W5TA 1EQJA 4UOPA 5HRTA 1ZEDA 1B8JA 2XR9A 2W5RA 3IDDA 3TG0A 1ZEFA 2XRGA 4ZG7A 4CXUA 1E3CP 3MK0A 5DLWA 2X98A 5GOVA 3T02A 1ALHA 3ED4A 4LRFA 3KD8A 3BDHA 3UN3A 4KAVA 4KJGA 2W5XA 3NKQA 5LQQA 3NKOA 1FSUA 5K4PA 3WAWA 1EJJA 4LREA 4UPHA 4UPKA 4MHXA 1ANIA 2QZUA 1KH5A 3BDGA 2GLQA 2W5WA 1P49A 1ALIA 1E33P 4KM4A 3IGYB 4UPIA 4LQYA 4UPLA 2W5QA 1N2KA 1EW2A 1KHJA 2W5VA 2ZKTA 4TN0A 3T00A 4CYRA 1URAA 5AJ9A 1ELYA 5DLVA 1E2SP 5IJQA 1EI6A 3SZYA 5DLTA 5L0EA 4NWJA 1KH9A 3CMRA 4CYSA 4GTWA 3NKNA 3T01A 1ELXA 4LRAA 4NWXA 2ANHA 3UO0A 1EW9A 3MK1A 2IUCB 5TJ3A 3SZZA 4B56A 3TX0A 1SHNA 3LXQA 1KH4A 1O99A 3NKRA 3NKPA 2VQRA 4GTZA 4QAXA 3IGZB 4LR7A 2W8DA 4FDIA
chains in the Genus database with same CATH topology
4LR9A 3B5QA 4LR8A 1ED9A 3A52A 5L0BA 3UN2A 1ZEBA 1Y7AA 3TWZA 1HDHA 4ZGAA 4LRDA 4KAYA 5INHA 1EW8A 1SHQA 2GSOA 1URBA 2D1GA 2GSUA 3M8YA 3M8WA 1O98A 3MK2A 1KHNA 4LR2A 1HJKA 2G9YA 3E2DA 3M7VA 3NVLA 3Q3QA 5LRNA 2GSNA 3DPCA 4GTXA 1ANJA 3UNYA 1AJDA 1AJCA 3WAYA 5GRRA 2W5SA 3WBHA 4CXKA 3WAVA 5KXAA 4LRBA 5LRMA 4KJDA 1ELZA 2W8SA 4LRCA 4ZG6A 1HQAA 4N7TA 5L0KA 3BDGB 1AJAA 1Y6VA 3M8ZA 3BDFA 5EGEA 1AJBA 1E1ZP 2GA3A 5C66A 3UN5A 1ALKA 2IFYA 4FDJA 2IUCA 3NKMA 4UORA 1N2LA 1KH7A 4UOOA 5EGHA 1KHLA 1ALJA 1K7HA 1KHKA 4YR1A 2RH6A 4MIVA 1AUKA 3DYCA 4CXSA 5LIAA 4MY4A 3OT9A 5IJSA 4GTYA 4ZG9A 1ED8A 3WAXA 2W5TA 1EQJA 4UOPA 5HRTA 1ZEDA 1B8JA 2XR9A 2W5RA 3IDDA 3TG0A 1ZEFA 2XRGA 4ZG7A 4CXUA 1E3CP 3MK0A 5DLWA 2X98A 5GOVA 3T02A 1ALHA 3ED4A 4LRFA 3KD8A 3BDHA 3UN3A 4KAVA 4KJGA 2W5XA 3NKQA 5LQQA 3NKOA 1FSUA 5K4PA 3WAWA 1EJJA 4LREA 4UPHA 4UPKA 4MHXA 1ANIA 2QZUA 1KH5A 3BDGA 2GLQA 2W5WA 1P49A 1ALIA 1E33P 4KM4A 3IGYB 4UPIA 4LQYA 4UPLA 2W5QA 1N2KA 1EW2A 1KHJA 2W5VA 2ZKTA 4TN0A 3T00A 4CYRA 1URAA 5AJ9A 1ELYA 5DLVA 1E2SP 5IJQA 1EI6A 3SZYA 5DLTA 5L0EA 4NWJA 1KH9A 3CMRA 4CYSA 4GTWA 3NKNA 3T01A 1ELXA 4LRAA 4NWXA 2ANHA 3UO0A 1EW9A 3MK1A 2IUCB 5TJ3A 3SZZA 4B56A 3TX0A 1SHNA 3LXQA 1KH4A 1O99A 3NKRA 3NKPA 2VQRA 4GTZA 4QAXA 3IGZB 4LR7A 2W8DA 4FDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LR9 A;  3B5Q A;  4LR8 A;  1ED9 A;  3A52 A;  5L0B A;  3UN2 A;  1ZEB A;  1Y7A A;  3TWZ A;  1HDH A;  4ZGA A;  4LRD A;  4KAY A;  5INH A;  1EW8 A;  1SHQ A;  2GSO A;  1URB A;  2D1G A;  2GSU A;  3M8Y A;  3M8W A;  1O98 A;  3MK2 A;  1KHN A;  4LR2 A;  1HJK A;  2G9Y A;  3E2D A;  3M7V A;  3NVL A;  3Q3Q A;  5LRN A;  2GSN A;  3DPC A;  4GTX A;  1ANJ A;  3UNY A;  1AJD A;  1AJC A;  3WAY A;  5GRR A;  2W5S A;  3WBH A;  4CXK A;  3WAV A;  5KXA A;  4LRB A;  5LRM A;  4KJD A;  1ELZ A;  2W8S A;  4LRC A;  4ZG6 A;  1HQA A;  4N7T A;  5L0K A;  3BDG B;  1AJA A;  1Y6V A;  3M8Z A;  3BDF A;  5EGE A;  1AJB A;  1E1Z P;  2GA3 A;  5C66 A;  3UN5 A;  1ALK A;  2IFY A;  4FDJ A;  2IUC A;  3NKM A;  4UOR A;  1N2L A;  1KH7 A;  4UOO A;  5EGH A;  1KHL A;  1ALJ A;  1K7H A;  1KHK A;  4YR1 A;  2RH6 A;  4MIV A;  1AUK A;  3DYC A;  4CXS A;  5LIA A;  4MY4 A;  3OT9 A;  5IJS A;  4GTY A;  4ZG9 A;  1ED8 A;  3WAX A;  2W5T A;  1EQJ A;  4UOP A;  5HRT A;  1ZED A;  1B8J A;  2XR9 A;  2W5R A;  3IDD A;  3TG0 A;  1ZEF A;  2XRG A;  4ZG7 A;  4CXU A;  1E3C P;  3MK0 A;  5DLW A;  2X98 A;  5GOV A;  3T02 A;  1ALH A;  3ED4 A;  4LRF A;  3KD8 A;  3BDH A;  3UN3 A;  4KAV A;  4KJG A;  2W5X A;  3NKQ A;  5LQQ A;  3NKO A;  1FSU A;  5K4P A;  3WAW A;  1EJJ A;  4LRE A;  4UPH A;  4UPK A;  4MHX A;  1ANI A;  2QZU A;  1KH5 A;  3BDG A;  2GLQ A;  2W5W A;  1P49 A;  1ALI A;  1E33 P;  4KM4 A;  3IGY B;  4UPI A;  4LQY A;  4UPL A;  2W5Q A;  1N2K A;  1EW2 A;  1KHJ A;  2W5V A;  2ZKT A;  4TN0 A;  3T00 A;  4CYR A;  1URA A;  5AJ9 A;  1ELY A;  5DLV A;  1E2S P;  5IJQ A;  1EI6 A;  3SZY A;  5DLT A;  5L0E A;  4NWJ A;  1KH9 A;  3CMR A;  4CYS A;  4GTW A;  3NKN A;  3T01 A;  1ELX A;  4LRA A;  4NWX A;  2ANH A;  3UO0 A;  1EW9 A;  3MK1 A;  2IUC B;  5TJ3 A;  3SZZ A;  4B56 A;  3TX0 A;  1SHN A;  3LXQ A;  1KH4 A;  1O99 A;  3NKR A;  3NKP A;  2VQR A;  4GTZ A;  4QAX A;  3IGZ B;  4LR7 A;  2W8D A;  4FDI A; 
#chains in the Genus database with same CATH topology
 4LR9 A;  3B5Q A;  4LR8 A;  1ED9 A;  3A52 A;  5L0B A;  3UN2 A;  1ZEB A;  1Y7A A;  3TWZ A;  1HDH A;  4ZGA A;  4LRD A;  4KAY A;  5INH A;  1EW8 A;  1SHQ A;  2GSO A;  1URB A;  2D1G A;  2GSU A;  3M8Y A;  3M8W A;  1O98 A;  3MK2 A;  1KHN A;  4LR2 A;  1HJK A;  2G9Y A;  3E2D A;  3M7V A;  3NVL A;  3Q3Q A;  5LRN A;  2GSN A;  3DPC A;  4GTX A;  1ANJ A;  3UNY A;  1AJD A;  1AJC A;  3WAY A;  5GRR A;  2W5S A;  3WBH A;  4CXK A;  3WAV A;  5KXA A;  4LRB A;  5LRM A;  4KJD A;  1ELZ A;  2W8S A;  4LRC A;  4ZG6 A;  1HQA A;  4N7T A;  5L0K A;  3BDG B;  1AJA A;  1Y6V A;  3M8Z A;  3BDF A;  5EGE A;  1AJB A;  1E1Z P;  2GA3 A;  5C66 A;  3UN5 A;  1ALK A;  2IFY A;  4FDJ A;  2IUC A;  3NKM A;  4UOR A;  1N2L A;  1KH7 A;  4UOO A;  5EGH A;  1KHL A;  1ALJ A;  1K7H A;  1KHK A;  4YR1 A;  2RH6 A;  4MIV A;  1AUK A;  3DYC A;  4CXS A;  5LIA A;  4MY4 A;  3OT9 A;  5IJS A;  4GTY A;  4ZG9 A;  1ED8 A;  3WAX A;  2W5T A;  1EQJ A;  4UOP A;  5HRT A;  1ZED A;  1B8J A;  2XR9 A;  2W5R A;  3IDD A;  3TG0 A;  1ZEF A;  2XRG A;  4ZG7 A;  4CXU A;  1E3C P;  3MK0 A;  5DLW A;  2X98 A;  5GOV A;  3T02 A;  1ALH A;  3ED4 A;  4LRF A;  3KD8 A;  3BDH A;  3UN3 A;  4KAV A;  4KJG A;  2W5X A;  3NKQ A;  5LQQ A;  3NKO A;  1FSU A;  5K4P A;  3WAW A;  1EJJ A;  4LRE A;  4UPH A;  4UPK A;  4MHX A;  1ANI A;  2QZU A;  1KH5 A;  3BDG A;  2GLQ A;  2W5W A;  1P49 A;  1ALI A;  1E33 P;  4KM4 A;  3IGY B;  4UPI A;  4LQY A;  4UPL A;  2W5Q A;  1N2K A;  1EW2 A;  1KHJ A;  2W5V A;  2ZKT A;  4TN0 A;  3T00 A;  4CYR A;  1URA A;  5AJ9 A;  1ELY A;  5DLV A;  1E2S P;  5IJQ A;  1EI6 A;  3SZY A;  5DLT A;  5L0E A;  4NWJ A;  1KH9 A;  3CMR A;  4CYS A;  4GTW A;  3NKN A;  3T01 A;  1ELX A;  4LRA A;  4NWX A;  2ANH A;  3UO0 A;  1EW9 A;  3MK1 A;  2IUC B;  5TJ3 A;  3SZZ A;  4B56 A;  3TX0 A;  1SHN A;  3LXQ A;  1KH4 A;  1O99 A;  3NKR A;  3NKP A;  2VQR A;  4GTZ A;  4QAX A;  3IGZ B;  4LR7 A;  2W8D A;  4FDI A; 
#chains in the Genus database with same CATH homology
 4LR9 A;  3B5Q A;  4LR8 A;  1ED9 A;  3A52 A;  5L0B A;  3UN2 A;  1ZEB A;  1Y7A A;  3TWZ A;  1HDH A;  4ZGA A;  4LRD A;  4KAY A;  5INH A;  1EW8 A;  1SHQ A;  2GSO A;  1URB A;  2D1G A;  2GSU A;  3M8Y A;  3M8W A;  1O98 A;  3MK2 A;  1KHN A;  4LR2 A;  1HJK A;  2G9Y A;  3E2D A;  3M7V A;  3NVL A;  3Q3Q A;  5LRN A;  2GSN A;  3DPC A;  4GTX A;  1ANJ A;  3UNY A;  1AJD A;  1AJC A;  3WAY A;  5GRR A;  2W5S A;  3WBH A;  4CXK A;  3WAV A;  5KXA A;  4LRB A;  5LRM A;  4KJD A;  1ELZ A;  2W8S A;  4LRC A;  4ZG6 A;  1HQA A;  4N7T A;  5L0K A;  3BDG B;  1AJA A;  1Y6V A;  3M8Z A;  3BDF A;  5EGE A;  1AJB A;  1E1Z P;  2GA3 A;  5C66 A;  3UN5 A;  1ALK A;  2IFY A;  4FDJ A;  2IUC A;  3NKM A;  4UOR A;  1N2L A;  1KH7 A;  4UOO A;  5EGH A;  1KHL A;  1ALJ A;  1K7H A;  1KHK A;  4YR1 A;  2RH6 A;  4MIV A;  1AUK A;  3DYC A;  4CXS A;  5LIA A;  4MY4 A;  3OT9 A;  5IJS A;  4GTY A;  4ZG9 A;  1ED8 A;  3WAX A;  2W5T A;  1EQJ A;  4UOP A;  5HRT A;  1ZED A;  1B8J A;  2XR9 A;  2W5R A;  3IDD A;  3TG0 A;  1ZEF A;  2XRG A;  4ZG7 A;  4CXU A;  1E3C P;  3MK0 A;  5DLW A;  2X98 A;  5GOV A;  3T02 A;  1ALH A;  3ED4 A;  4LRF A;  3KD8 A;  3BDH A;  3UN3 A;  4KAV A;  4KJG A;  2W5X A;  3NKQ A;  5LQQ A;  3NKO A;  1FSU A;  5K4P A;  3WAW A;  1EJJ A;  4LRE A;  4UPH A;  4UPK A;  4MHX A;  1ANI A;  2QZU A;  1KH5 A;  3BDG A;  2GLQ A;  2W5W A;  1P49 A;  1ALI A;  1E33 P;  4KM4 A;  3IGY B;  4UPI A;  4LQY A;  4UPL A;  2W5Q A;  1N2K A;  1EW2 A;  1KHJ A;  2W5V A;  2ZKT A;  4TN0 A;  3T00 A;  4CYR A;  1URA A;  5AJ9 A;  1ELY A;  5DLV A;  1E2S P;  5IJQ A;  1EI6 A;  3SZY A;  5DLT A;  5L0E A;  4NWJ A;  1KH9 A;  3CMR A;  4CYS A;  4GTW A;  3NKN A;  3T01 A;  1ELX A;  4LRA A;  4NWX A;  2ANH A;  3UO0 A;  1EW9 A;  3MK1 A;  2IUC B;  5TJ3 A;  3SZZ A;  4B56 A;  3TX0 A;  1SHN A;  3LXQ A;  1KH4 A;  1O99 A;  3NKR A;  3NKP A;  2VQR A;  4GTZ A;  4QAX A;  3IGZ B;  4LR7 A;  2W8D A;  4FDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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