1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
5GRRA 1ANIA 3WAVA 3T02A 1KHJA 4FDIA 3NKRA 5GOVA 3TWZA 1E3CP 2RH6A 4KAVA 1AJDA 2W5TA 3M7VA 1N2LA 2D1GA 2ZKTA 4ZG9A 5DLTA 4NWXA 3M8YA 2XRGA 4CYSA 1O99A 4LRCA 5INHA 1AJAA 1KH4A 2XR9A 1EJJA 1E1ZP 1ED8A 1Y7AA 3Q3QA 4B56A 4UPHA 1EI6A 3MK0A 3CMRA 5LRMA 3BDGB 4ZGAA 1KHNA 3A52A 4KM4A 1Y6VA 1KH9A 1EW9A 4NWJA 5DLWA 2ANHA 1AJBA 4ZG7A 1KHKA 2IUCB 1N2KA 1O98A 4KJDA 4CXKA 2W8SA 4ZG6A 4CYRA 1ALKA 3NKPA 5L0BA 4UPIA 4GTZA 4LREA 3M8ZA 1ED9A 3NKNA 5K4PA 1E2SP 1KH7A 1ZEFA 3NVLA 3LXQA 1ELZA 5TJ3A 1ALJA 1SHQA 3BDHA 4GTXA 1ZEBA 5LRNA 4N7TA 2W5RA 3T01A 5KXAA 3B5QA 3MK1A 1KH5A 3T00A 3KD8A 5AJ9A 5DLVA 3M8WA 2GSNA 3UN2A 1SHNA 4UORA 3WBHA 4TN0A 1ZEDA 4LR7A 4LQYA 4LR2A 5C66A 2X98A 2GSUA 3BDFA 3IGYB 4KAYA 3UN5A 3DPCA 1AJCA 3BDGA 1FSUA 3NKQA 4FDJA 3WAWA 2GA3A 5HRTA 4LRBA 2IFYA 1B8JA 3IDDA 4UOPA 5EGHA 1K7HA 4KJGA 3UO0A 1HQAA 1ELXA 4LRDA 4LR9A 5IJSA 1KHLA 4UPLA 2GSOA 3SZYA 1E33P 4CXSA 3ED4A 2W5XA 4LRAA 2G9YA 3IGZB 4LRFA 4GTYA 3WAXA 4UOOA 3DYCA 2VQRA 1ANJA 5EGEA 1AUKA 4MHXA 2IUCA 3TG0A 3UNYA 2GLQA 5L0KA 5L0EA 1ALIA 4CXUA 1EW2A 1ALHA 5IJQA 2W5SA 1HDHA 4YR1A 4QAXA 1EQJA 4LR8A 4GTWA 1URBA 3E2DA 2W8DA 3OT9A 2W5WA 2W5QA 1URAA 2W5VA 5LQQA 3SZZA 3NKMA 2QZUA 4UPKA 3TX0A 1EW8A 1P49A 5LIAA 3MK2A 4MY4A 3UN3A 4MIVA 1HJKA 3WAYA 3NKOA 1ELYA
chains in the Genus database with same CATH superfamily
5GRRA 1ANIA 3WAVA 3T02A 1KHJA 4FDIA 3NKRA 5GOVA 3TWZA 1E3CP 2RH6A 4KAVA 1AJDA 2W5TA 3M7VA 1N2LA 2D1GA 2ZKTA 4ZG9A 5DLTA 4NWXA 3M8YA 2XRGA 4CYSA 1O99A 4LRCA 5INHA 1AJAA 1KH4A 2XR9A 1EJJA 1E1ZP 1ED8A 1Y7AA 3Q3QA 4B56A 4UPHA 1EI6A 3MK0A 3CMRA 5LRMA 3BDGB 4ZGAA 1KHNA 3A52A 4KM4A 1Y6VA 1KH9A 1EW9A 4NWJA 5DLWA 2ANHA 1AJBA 4ZG7A 1KHKA 2IUCB 1N2KA 1O98A 4KJDA 4CXKA 2W8SA 4ZG6A 4CYRA 1ALKA 3NKPA 5L0BA 4UPIA 4GTZA 4LREA 3M8ZA 1ED9A 3NKNA 5K4PA 1E2SP 1KH7A 1ZEFA 3NVLA 3LXQA 1ELZA 5TJ3A 1ALJA 1SHQA 3BDHA 4GTXA 1ZEBA 5LRNA 4N7TA 2W5RA 3T01A 5KXAA 3B5QA 3MK1A 1KH5A 3T00A 3KD8A 5AJ9A 5DLVA 3M8WA 2GSNA 3UN2A 1SHNA 4UORA 3WBHA 4TN0A 1ZEDA 4LR7A 4LQYA 4LR2A 5C66A 2X98A 2GSUA 3BDFA 3IGYB 4KAYA 3UN5A 3DPCA 1AJCA 3BDGA 1FSUA 3NKQA 4FDJA 3WAWA 2GA3A 5HRTA 4LRBA 2IFYA 1B8JA 3IDDA 4UOPA 5EGHA 1K7HA 4KJGA 3UO0A 1HQAA 1ELXA 4LRDA 4LR9A 5IJSA 1KHLA 4UPLA 2GSOA 3SZYA 1E33P 4CXSA 3ED4A 2W5XA 4LRAA 2G9YA 3IGZB 4LRFA 4GTYA 3WAXA 4UOOA 3DYCA 2VQRA 1ANJA 5EGEA 1AUKA 4MHXA 2IUCA 3TG0A 3UNYA 2GLQA 5L0KA 5L0EA 1ALIA 4CXUA 1EW2A 1ALHA 5IJQA 2W5SA 1HDHA 4YR1A 4QAXA 1EQJA 4LR8A 4GTWA 1URBA 3E2DA 2W8DA 3OT9A 2W5WA 2W5QA 1URAA 2W5VA 5LQQA 3SZZA 3NKMA 2QZUA 4UPKA 3TX0A 1EW8A 1P49A 5LIAA 3MK2A 4MY4A 3UN3A 4MIVA 1HJKA 3WAYA 3NKOA 1ELYA
chains in the Genus database with same CATH topology
5GRRA 1ANIA 3WAVA 3T02A 1KHJA 4FDIA 3NKRA 5GOVA 3TWZA 1E3CP 2RH6A 4KAVA 1AJDA 2W5TA 3M7VA 1N2LA 2D1GA 2ZKTA 4ZG9A 5DLTA 4NWXA 3M8YA 2XRGA 4CYSA 1O99A 4LRCA 5INHA 1AJAA 1KH4A 2XR9A 1EJJA 1E1ZP 1ED8A 1Y7AA 3Q3QA 4B56A 4UPHA 1EI6A 3MK0A 3CMRA 5LRMA 3BDGB 4ZGAA 1KHNA 3A52A 4KM4A 1Y6VA 1KH9A 1EW9A 4NWJA 5DLWA 2ANHA 1AJBA 4ZG7A 1KHKA 2IUCB 1N2KA 1O98A 4KJDA 4CXKA 2W8SA 4ZG6A 4CYRA 1ALKA 3NKPA 5L0BA 4UPIA 4GTZA 4LREA 3M8ZA 1ED9A 3NKNA 5K4PA 1E2SP 1KH7A 1ZEFA 3NVLA 3LXQA 1ELZA 5TJ3A 1ALJA 1SHQA 3BDHA 4GTXA 1ZEBA 5LRNA 4N7TA 2W5RA 3T01A 5KXAA 3B5QA 3MK1A 1KH5A 3T00A 3KD8A 5AJ9A 5DLVA 3M8WA 2GSNA 3UN2A 1SHNA 4UORA 3WBHA 4TN0A 1ZEDA 4LR7A 4LQYA 4LR2A 5C66A 2X98A 2GSUA 3BDFA 3IGYB 4KAYA 3UN5A 3DPCA 1AJCA 3BDGA 1FSUA 3NKQA 4FDJA 3WAWA 2GA3A 5HRTA 4LRBA 2IFYA 1B8JA 3IDDA 4UOPA 5EGHA 1K7HA 4KJGA 3UO0A 1HQAA 1ELXA 4LRDA 4LR9A 5IJSA 1KHLA 4UPLA 2GSOA 3SZYA 1E33P 4CXSA 3ED4A 2W5XA 4LRAA 2G9YA 3IGZB 4LRFA 4GTYA 3WAXA 4UOOA 3DYCA 2VQRA 1ANJA 5EGEA 1AUKA 4MHXA 2IUCA 3TG0A 3UNYA 2GLQA 5L0KA 5L0EA 1ALIA 4CXUA 1EW2A 1ALHA 5IJQA 2W5SA 1HDHA 4YR1A 4QAXA 1EQJA 4LR8A 4GTWA 1URBA 3E2DA 2W8DA 3OT9A 2W5WA 2W5QA 1URAA 2W5VA 5LQQA 3SZZA 3NKMA 2QZUA 4UPKA 3TX0A 1EW8A 1P49A 5LIAA 3MK2A 4MY4A 3UN3A 4MIVA 1HJKA 3WAYA 3NKOA 1ELYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GRR A;  1ANI A;  3WAV A;  3T02 A;  1KHJ A;  4FDI A;  3NKR A;  5GOV A;  3TWZ A;  1E3C P;  2RH6 A;  4KAV A;  1AJD A;  2W5T A;  3M7V A;  1N2L A;  2D1G A;  2ZKT A;  4ZG9 A;  5DLT A;  4NWX A;  3M8Y A;  2XRG A;  4CYS A;  1O99 A;  4LRC A;  5INH A;  1AJA A;  1KH4 A;  2XR9 A;  1EJJ A;  1E1Z P;  1ED8 A;  1Y7A A;  3Q3Q A;  4B56 A;  4UPH A;  1EI6 A;  3MK0 A;  3CMR A;  5LRM A;  3BDG B;  4ZGA A;  1KHN A;  3A52 A;  4KM4 A;  1Y6V A;  1KH9 A;  1EW9 A;  4NWJ A;  5DLW A;  2ANH A;  1AJB A;  4ZG7 A;  1KHK A;  2IUC B;  1N2K A;  1O98 A;  4KJD A;  4CXK A;  2W8S A;  4ZG6 A;  4CYR A;  1ALK A;  3NKP A;  5L0B A;  4UPI A;  4GTZ A;  4LRE A;  3M8Z A;  1ED9 A;  3NKN A;  5K4P A;  1E2S P;  1KH7 A;  1ZEF A;  3NVL A;  3LXQ A;  1ELZ A;  5TJ3 A;  1ALJ A;  1SHQ A;  3BDH A;  4GTX A;  1ZEB A;  5LRN A;  4N7T A;  2W5R A;  3T01 A;  5KXA A;  3B5Q A;  3MK1 A;  1KH5 A;  3T00 A;  3KD8 A;  5AJ9 A;  5DLV A;  3M8W A;  2GSN A;  3UN2 A;  1SHN A;  4UOR A;  3WBH A;  4TN0 A;  1ZED A;  4LR7 A;  4LQY A;  4LR2 A;  5C66 A;  2X98 A;  2GSU A;  3BDF A;  3IGY B;  4KAY A;  3UN5 A;  3DPC A;  1AJC A;  3BDG A;  1FSU A;  3NKQ A;  4FDJ A;  3WAW A;  2GA3 A;  5HRT A;  4LRB A;  2IFY A;  1B8J A;  3IDD A;  4UOP A;  5EGH A;  1K7H A;  4KJG A;  3UO0 A;  1HQA A;  1ELX A;  4LRD A;  4LR9 A;  5IJS A;  1KHL A;  4UPL A;  2GSO A;  3SZY A;  1E33 P;  4CXS A;  3ED4 A;  2W5X A;  4LRA A;  2G9Y A;  3IGZ B;  4LRF A;  4GTY A;  3WAX A;  4UOO A;  3DYC A;  2VQR A;  1ANJ A;  5EGE A;  1AUK A;  4MHX A;  2IUC A;  3TG0 A;  3UNY A;  2GLQ A;  5L0K A;  5L0E A;  1ALI A;  4CXU A;  1EW2 A;  1ALH A;  5IJQ A;  2W5S A;  1HDH A;  4YR1 A;  4QAX A;  1EQJ A;  4LR8 A;  4GTW A;  1URB A;  3E2D A;  2W8D A;  3OT9 A;  2W5W A;  2W5Q A;  1URA A;  2W5V A;  5LQQ A;  3SZZ A;  3NKM A;  2QZU A;  4UPK A;  3TX0 A;  1EW8 A;  1P49 A;  5LIA A;  3MK2 A;  4MY4 A;  3UN3 A;  4MIV A;  1HJK A;  3WAY A;  3NKO A;  1ELY A; 
#chains in the Genus database with same CATH topology
 5GRR A;  1ANI A;  3WAV A;  3T02 A;  1KHJ A;  4FDI A;  3NKR A;  5GOV A;  3TWZ A;  1E3C P;  2RH6 A;  4KAV A;  1AJD A;  2W5T A;  3M7V A;  1N2L A;  2D1G A;  2ZKT A;  4ZG9 A;  5DLT A;  4NWX A;  3M8Y A;  2XRG A;  4CYS A;  1O99 A;  4LRC A;  5INH A;  1AJA A;  1KH4 A;  2XR9 A;  1EJJ A;  1E1Z P;  1ED8 A;  1Y7A A;  3Q3Q A;  4B56 A;  4UPH A;  1EI6 A;  3MK0 A;  3CMR A;  5LRM A;  3BDG B;  4ZGA A;  1KHN A;  3A52 A;  4KM4 A;  1Y6V A;  1KH9 A;  1EW9 A;  4NWJ A;  5DLW A;  2ANH A;  1AJB A;  4ZG7 A;  1KHK A;  2IUC B;  1N2K A;  1O98 A;  4KJD A;  4CXK A;  2W8S A;  4ZG6 A;  4CYR A;  1ALK A;  3NKP A;  5L0B A;  4UPI A;  4GTZ A;  4LRE A;  3M8Z A;  1ED9 A;  3NKN A;  5K4P A;  1E2S P;  1KH7 A;  1ZEF A;  3NVL A;  3LXQ A;  1ELZ A;  5TJ3 A;  1ALJ A;  1SHQ A;  3BDH A;  4GTX A;  1ZEB A;  5LRN A;  4N7T A;  2W5R A;  3T01 A;  5KXA A;  3B5Q A;  3MK1 A;  1KH5 A;  3T00 A;  3KD8 A;  5AJ9 A;  5DLV A;  3M8W A;  2GSN A;  3UN2 A;  1SHN A;  4UOR A;  3WBH A;  4TN0 A;  1ZED A;  4LR7 A;  4LQY A;  4LR2 A;  5C66 A;  2X98 A;  2GSU A;  3BDF A;  3IGY B;  4KAY A;  3UN5 A;  3DPC A;  1AJC A;  3BDG A;  1FSU A;  3NKQ A;  4FDJ A;  3WAW A;  2GA3 A;  5HRT A;  4LRB A;  2IFY A;  1B8J A;  3IDD A;  4UOP A;  5EGH A;  1K7H A;  4KJG A;  3UO0 A;  1HQA A;  1ELX A;  4LRD A;  4LR9 A;  5IJS A;  1KHL A;  4UPL A;  2GSO A;  3SZY A;  1E33 P;  4CXS A;  3ED4 A;  2W5X A;  4LRA A;  2G9Y A;  3IGZ B;  4LRF A;  4GTY A;  3WAX A;  4UOO A;  3DYC A;  2VQR A;  1ANJ A;  5EGE A;  1AUK A;  4MHX A;  2IUC A;  3TG0 A;  3UNY A;  2GLQ A;  5L0K A;  5L0E A;  1ALI A;  4CXU A;  1EW2 A;  1ALH A;  5IJQ A;  2W5S A;  1HDH A;  4YR1 A;  4QAX A;  1EQJ A;  4LR8 A;  4GTW A;  1URB A;  3E2D A;  2W8D A;  3OT9 A;  2W5W A;  2W5Q A;  1URA A;  2W5V A;  5LQQ A;  3SZZ A;  3NKM A;  2QZU A;  4UPK A;  3TX0 A;  1EW8 A;  1P49 A;  5LIA A;  3MK2 A;  4MY4 A;  3UN3 A;  4MIV A;  1HJK A;  3WAY A;  3NKO A;  1ELY A; 
#chains in the Genus database with same CATH homology
 5GRR A;  1ANI A;  3WAV A;  3T02 A;  1KHJ A;  4FDI A;  3NKR A;  5GOV A;  3TWZ A;  1E3C P;  2RH6 A;  4KAV A;  1AJD A;  2W5T A;  3M7V A;  1N2L A;  2D1G A;  2ZKT A;  4ZG9 A;  5DLT A;  4NWX A;  3M8Y A;  2XRG A;  4CYS A;  1O99 A;  4LRC A;  5INH A;  1AJA A;  1KH4 A;  2XR9 A;  1EJJ A;  1E1Z P;  1ED8 A;  1Y7A A;  3Q3Q A;  4B56 A;  4UPH A;  1EI6 A;  3MK0 A;  3CMR A;  5LRM A;  3BDG B;  4ZGA A;  1KHN A;  3A52 A;  4KM4 A;  1Y6V A;  1KH9 A;  1EW9 A;  4NWJ A;  5DLW A;  2ANH A;  1AJB A;  4ZG7 A;  1KHK A;  2IUC B;  1N2K A;  1O98 A;  4KJD A;  4CXK A;  2W8S A;  4ZG6 A;  4CYR A;  1ALK A;  3NKP A;  5L0B A;  4UPI A;  4GTZ A;  4LRE A;  3M8Z A;  1ED9 A;  3NKN A;  5K4P A;  1E2S P;  1KH7 A;  1ZEF A;  3NVL A;  3LXQ A;  1ELZ A;  5TJ3 A;  1ALJ A;  1SHQ A;  3BDH A;  4GTX A;  1ZEB A;  5LRN A;  4N7T A;  2W5R A;  3T01 A;  5KXA A;  3B5Q A;  3MK1 A;  1KH5 A;  3T00 A;  3KD8 A;  5AJ9 A;  5DLV A;  3M8W A;  2GSN A;  3UN2 A;  1SHN A;  4UOR A;  3WBH A;  4TN0 A;  1ZED A;  4LR7 A;  4LQY A;  4LR2 A;  5C66 A;  2X98 A;  2GSU A;  3BDF A;  3IGY B;  4KAY A;  3UN5 A;  3DPC A;  1AJC A;  3BDG A;  1FSU A;  3NKQ A;  4FDJ A;  3WAW A;  2GA3 A;  5HRT A;  4LRB A;  2IFY A;  1B8J A;  3IDD A;  4UOP A;  5EGH A;  1K7H A;  4KJG A;  3UO0 A;  1HQA A;  1ELX A;  4LRD A;  4LR9 A;  5IJS A;  1KHL A;  4UPL A;  2GSO A;  3SZY A;  1E33 P;  4CXS A;  3ED4 A;  2W5X A;  4LRA A;  2G9Y A;  3IGZ B;  4LRF A;  4GTY A;  3WAX A;  4UOO A;  3DYC A;  2VQR A;  1ANJ A;  5EGE A;  1AUK A;  4MHX A;  2IUC A;  3TG0 A;  3UNY A;  2GLQ A;  5L0K A;  5L0E A;  1ALI A;  4CXU A;  1EW2 A;  1ALH A;  5IJQ A;  2W5S A;  1HDH A;  4YR1 A;  4QAX A;  1EQJ A;  4LR8 A;  4GTW A;  1URB A;  3E2D A;  2W8D A;  3OT9 A;  2W5W A;  2W5Q A;  1URA A;  2W5V A;  5LQQ A;  3SZZ A;  3NKM A;  2QZU A;  4UPK A;  3TX0 A;  1EW8 A;  1P49 A;  5LIA A;  3MK2 A;  4MY4 A;  3UN3 A;  4MIV A;  1HJK A;  3WAY A;  3NKO A;  1ELY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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