1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
1KH9A 3M8YA 3WAVA 3MK1A 4GTZA 2ZKTA 1KHKA 1KHNA 4LRCA 5EGEA 5INHA 3WBHA 1E33P 1P49A 1KH5A 2G9YA 4MIVA 2W5RA 3KD8A 1AJCA 3DYCA 4FDJA 4LRDA 4N7TA 3BDFA 3B5QA 1ELXA 1AJAA 3UN2A 1FSUA 3UN5A 1HQAA 4LRAA 4CXKA 4YR1A 3A52A 1EJJA 4LQYA 2IUCA 3IGZB 3NKNA 1KH4A 2W8SA 3TG0A 4KAVA 4NWJA 5IJQA 3M8ZA 5LQQA 2VQRA 4LR2A 1KH7A 1ALHA 1E1ZP 4GTYA 4UPHA 3UO0A 4KM4A 4FDIA 3BDGB 3NKPA 5GRRA 1KHJA 4MY4A 4CXSA 1ZEFA 4KJGA 4GTXA 4KJDA 3T02A 5L0BA 2RH6A 4B56A 5LRNA 3NVLA 1ELYA 3MK2A 1EW9A 2IFYA 3SZZA 3E2DA 1URBA 5LIAA 1ALJA 1EW2A 4NWXA 3IGYB 3WAYA 2GLQA 3T01A 2W5SA 2W5WA 4LR7A 3IDDA 5AJ9A 1SHQA 5DLVA 2GSUA 1AUKA 2W5TA 3OT9A 1AJDA 4LRFA 2IUCB 4LREA 1SHNA 5KXAA 5L0KA 2XRGA 1KHLA 4UPIA 4CYSA 2QZUA 3NKMA 5K4PA 4QAXA 2ANHA 3MK0A 3NKQA 1E2SP 4LR9A 5GOVA 3M7VA 1B8JA 4UOPA 1ANJA 2X98A 4LRBA 1Y6VA 3M8WA 5C66A 5DLTA 3WAXA 1EQJA 2XR9A 3CMRA 4ZG6A 1ZEDA 2W5QA 3NKRA 1HDHA 4UPKA 1ED8A 3TWZA 4TN0A 1HJKA 1ANIA 1K7HA 5EGHA 3WAWA 1EW8A 4MHXA 4CYRA 1EI6A 5HRTA 5L0EA 1AJBA 3BDGA 2D1GA 3BDHA 4UOOA 3UN3A 1URAA 1N2KA 4ZG9A 4UORA 5DLWA 3UNYA 3T00A 4ZGAA 3TX0A 2W8DA 1O99A 3NKOA 4UPLA 4ZG7A 1N2LA 2GSOA 1Y7AA 5IJSA 3LXQA 4KAYA 5LRMA 2GA3A 1ED9A 2W5XA 1ALKA 3DPCA 1E3CP 1ZEBA 1ELZA 2W5VA 3Q3QA 4LR8A 3ED4A 1ALIA 4GTWA 1O98A 5TJ3A 3SZYA 2GSNA 4CXUA
chains in the Genus database with same CATH superfamily
1KH9A 3M8YA 3WAVA 3MK1A 4GTZA 2ZKTA 1KHKA 1KHNA 4LRCA 5EGEA 5INHA 3WBHA 1E33P 1P49A 1KH5A 2G9YA 4MIVA 2W5RA 3KD8A 1AJCA 3DYCA 4FDJA 4LRDA 4N7TA 3BDFA 3B5QA 1ELXA 1AJAA 3UN2A 1FSUA 3UN5A 1HQAA 4LRAA 4CXKA 4YR1A 3A52A 1EJJA 4LQYA 2IUCA 3IGZB 3NKNA 1KH4A 2W8SA 3TG0A 4KAVA 4NWJA 5IJQA 3M8ZA 5LQQA 2VQRA 4LR2A 1KH7A 1ALHA 1E1ZP 4GTYA 4UPHA 3UO0A 4KM4A 4FDIA 3BDGB 3NKPA 5GRRA 1KHJA 4MY4A 4CXSA 1ZEFA 4KJGA 4GTXA 4KJDA 3T02A 5L0BA 2RH6A 4B56A 5LRNA 3NVLA 1ELYA 3MK2A 1EW9A 2IFYA 3SZZA 3E2DA 1URBA 5LIAA 1ALJA 1EW2A 4NWXA 3IGYB 3WAYA 2GLQA 3T01A 2W5SA 2W5WA 4LR7A 3IDDA 5AJ9A 1SHQA 5DLVA 2GSUA 1AUKA 2W5TA 3OT9A 1AJDA 4LRFA 2IUCB 4LREA 1SHNA 5KXAA 5L0KA 2XRGA 1KHLA 4UPIA 4CYSA 2QZUA 3NKMA 5K4PA 4QAXA 2ANHA 3MK0A 3NKQA 1E2SP 4LR9A 5GOVA 3M7VA 1B8JA 4UOPA 1ANJA 2X98A 4LRBA 1Y6VA 3M8WA 5C66A 5DLTA 3WAXA 1EQJA 2XR9A 3CMRA 4ZG6A 1ZEDA 2W5QA 3NKRA 1HDHA 4UPKA 1ED8A 3TWZA 4TN0A 1HJKA 1ANIA 1K7HA 5EGHA 3WAWA 1EW8A 4MHXA 4CYRA 1EI6A 5HRTA 5L0EA 1AJBA 3BDGA 2D1GA 3BDHA 4UOOA 3UN3A 1URAA 1N2KA 4ZG9A 4UORA 5DLWA 3UNYA 3T00A 4ZGAA 3TX0A 2W8DA 1O99A 3NKOA 4UPLA 4ZG7A 1N2LA 2GSOA 1Y7AA 5IJSA 3LXQA 4KAYA 5LRMA 2GA3A 1ED9A 2W5XA 1ALKA 3DPCA 1E3CP 1ZEBA 1ELZA 2W5VA 3Q3QA 4LR8A 3ED4A 1ALIA 4GTWA 1O98A 5TJ3A 3SZYA 2GSNA 4CXUA
chains in the Genus database with same CATH topology
1KH9A 3M8YA 3WAVA 3MK1A 4GTZA 2ZKTA 1KHKA 1KHNA 4LRCA 5EGEA 5INHA 3WBHA 1E33P 1P49A 1KH5A 2G9YA 4MIVA 2W5RA 3KD8A 1AJCA 3DYCA 4FDJA 4LRDA 4N7TA 3BDFA 3B5QA 1ELXA 1AJAA 3UN2A 1FSUA 3UN5A 1HQAA 4LRAA 4CXKA 4YR1A 3A52A 1EJJA 4LQYA 2IUCA 3IGZB 3NKNA 1KH4A 2W8SA 3TG0A 4KAVA 4NWJA 5IJQA 3M8ZA 5LQQA 2VQRA 4LR2A 1KH7A 1ALHA 1E1ZP 4GTYA 4UPHA 3UO0A 4KM4A 4FDIA 3BDGB 3NKPA 5GRRA 1KHJA 4MY4A 4CXSA 1ZEFA 4KJGA 4GTXA 4KJDA 3T02A 5L0BA 2RH6A 4B56A 5LRNA 3NVLA 1ELYA 3MK2A 1EW9A 2IFYA 3SZZA 3E2DA 1URBA 5LIAA 1ALJA 1EW2A 4NWXA 3IGYB 3WAYA 2GLQA 3T01A 2W5SA 2W5WA 4LR7A 3IDDA 5AJ9A 1SHQA 5DLVA 2GSUA 1AUKA 2W5TA 3OT9A 1AJDA 4LRFA 2IUCB 4LREA 1SHNA 5KXAA 5L0KA 2XRGA 1KHLA 4UPIA 4CYSA 2QZUA 3NKMA 5K4PA 4QAXA 2ANHA 3MK0A 3NKQA 1E2SP 4LR9A 5GOVA 3M7VA 1B8JA 4UOPA 1ANJA 2X98A 4LRBA 1Y6VA 3M8WA 5C66A 5DLTA 3WAXA 1EQJA 2XR9A 3CMRA 4ZG6A 1ZEDA 2W5QA 3NKRA 1HDHA 4UPKA 1ED8A 3TWZA 4TN0A 1HJKA 1ANIA 1K7HA 5EGHA 3WAWA 1EW8A 4MHXA 4CYRA 1EI6A 5HRTA 5L0EA 1AJBA 3BDGA 2D1GA 3BDHA 4UOOA 3UN3A 1URAA 1N2KA 4ZG9A 4UORA 5DLWA 3UNYA 3T00A 4ZGAA 3TX0A 2W8DA 1O99A 3NKOA 4UPLA 4ZG7A 1N2LA 2GSOA 1Y7AA 5IJSA 3LXQA 4KAYA 5LRMA 2GA3A 1ED9A 2W5XA 1ALKA 3DPCA 1E3CP 1ZEBA 1ELZA 2W5VA 3Q3QA 4LR8A 3ED4A 1ALIA 4GTWA 1O98A 5TJ3A 3SZYA 2GSNA 4CXUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KH9 A;  3M8Y A;  3WAV A;  3MK1 A;  4GTZ A;  2ZKT A;  1KHK A;  1KHN A;  4LRC A;  5EGE A;  5INH A;  3WBH A;  1E33 P;  1P49 A;  1KH5 A;  2G9Y A;  4MIV A;  2W5R A;  3KD8 A;  1AJC A;  3DYC A;  4FDJ A;  4LRD A;  4N7T A;  3BDF A;  3B5Q A;  1ELX A;  1AJA A;  3UN2 A;  1FSU A;  3UN5 A;  1HQA A;  4LRA A;  4CXK A;  4YR1 A;  3A52 A;  1EJJ A;  4LQY A;  2IUC A;  3IGZ B;  3NKN A;  1KH4 A;  2W8S A;  3TG0 A;  4KAV A;  4NWJ A;  5IJQ A;  3M8Z A;  5LQQ A;  2VQR A;  4LR2 A;  1KH7 A;  1ALH A;  1E1Z P;  4GTY A;  4UPH A;  3UO0 A;  4KM4 A;  4FDI A;  3BDG B;  3NKP A;  5GRR A;  1KHJ A;  4MY4 A;  4CXS A;  1ZEF A;  4KJG A;  4GTX A;  4KJD A;  3T02 A;  5L0B A;  2RH6 A;  4B56 A;  5LRN A;  3NVL A;  1ELY A;  3MK2 A;  1EW9 A;  2IFY A;  3SZZ A;  3E2D A;  1URB A;  5LIA A;  1ALJ A;  1EW2 A;  4NWX A;  3IGY B;  3WAY A;  2GLQ A;  3T01 A;  2W5S A;  2W5W A;  4LR7 A;  3IDD A;  5AJ9 A;  1SHQ A;  5DLV A;  2GSU A;  1AUK A;  2W5T A;  3OT9 A;  1AJD A;  4LRF A;  2IUC B;  4LRE A;  1SHN A;  5KXA A;  5L0K A;  2XRG A;  1KHL A;  4UPI A;  4CYS A;  2QZU A;  3NKM A;  5K4P A;  4QAX A;  2ANH A;  3MK0 A;  3NKQ A;  1E2S P;  4LR9 A;  5GOV A;  3M7V A;  1B8J A;  4UOP A;  1ANJ A;  2X98 A;  4LRB A;  1Y6V A;  3M8W A;  5C66 A;  5DLT A;  3WAX A;  1EQJ A;  2XR9 A;  3CMR A;  4ZG6 A;  1ZED A;  2W5Q A;  3NKR A;  1HDH A;  4UPK A;  1ED8 A;  3TWZ A;  4TN0 A;  1HJK A;  1ANI A;  1K7H A;  5EGH A;  3WAW A;  1EW8 A;  4MHX A;  4CYR A;  1EI6 A;  5HRT A;  5L0E A;  1AJB A;  3BDG A;  2D1G A;  3BDH A;  4UOO A;  3UN3 A;  1URA A;  1N2K A;  4ZG9 A;  4UOR A;  5DLW A;  3UNY A;  3T00 A;  4ZGA A;  3TX0 A;  2W8D A;  1O99 A;  3NKO A;  4UPL A;  4ZG7 A;  1N2L A;  2GSO A;  1Y7A A;  5IJS A;  3LXQ A;  4KAY A;  5LRM A;  2GA3 A;  1ED9 A;  2W5X A;  1ALK A;  3DPC A;  1E3C P;  1ZEB A;  1ELZ A;  2W5V A;  3Q3Q A;  4LR8 A;  3ED4 A;  1ALI A;  4GTW A;  1O98 A;  5TJ3 A;  3SZY A;  2GSN A;  4CXU A; 
#chains in the Genus database with same CATH topology
 1KH9 A;  3M8Y A;  3WAV A;  3MK1 A;  4GTZ A;  2ZKT A;  1KHK A;  1KHN A;  4LRC A;  5EGE A;  5INH A;  3WBH A;  1E33 P;  1P49 A;  1KH5 A;  2G9Y A;  4MIV A;  2W5R A;  3KD8 A;  1AJC A;  3DYC A;  4FDJ A;  4LRD A;  4N7T A;  3BDF A;  3B5Q A;  1ELX A;  1AJA A;  3UN2 A;  1FSU A;  3UN5 A;  1HQA A;  4LRA A;  4CXK A;  4YR1 A;  3A52 A;  1EJJ A;  4LQY A;  2IUC A;  3IGZ B;  3NKN A;  1KH4 A;  2W8S A;  3TG0 A;  4KAV A;  4NWJ A;  5IJQ A;  3M8Z A;  5LQQ A;  2VQR A;  4LR2 A;  1KH7 A;  1ALH A;  1E1Z P;  4GTY A;  4UPH A;  3UO0 A;  4KM4 A;  4FDI A;  3BDG B;  3NKP A;  5GRR A;  1KHJ A;  4MY4 A;  4CXS A;  1ZEF A;  4KJG A;  4GTX A;  4KJD A;  3T02 A;  5L0B A;  2RH6 A;  4B56 A;  5LRN A;  3NVL A;  1ELY A;  3MK2 A;  1EW9 A;  2IFY A;  3SZZ A;  3E2D A;  1URB A;  5LIA A;  1ALJ A;  1EW2 A;  4NWX A;  3IGY B;  3WAY A;  2GLQ A;  3T01 A;  2W5S A;  2W5W A;  4LR7 A;  3IDD A;  5AJ9 A;  1SHQ A;  5DLV A;  2GSU A;  1AUK A;  2W5T A;  3OT9 A;  1AJD A;  4LRF A;  2IUC B;  4LRE A;  1SHN A;  5KXA A;  5L0K A;  2XRG A;  1KHL A;  4UPI A;  4CYS A;  2QZU A;  3NKM A;  5K4P A;  4QAX A;  2ANH A;  3MK0 A;  3NKQ A;  1E2S P;  4LR9 A;  5GOV A;  3M7V A;  1B8J A;  4UOP A;  1ANJ A;  2X98 A;  4LRB A;  1Y6V A;  3M8W A;  5C66 A;  5DLT A;  3WAX A;  1EQJ A;  2XR9 A;  3CMR A;  4ZG6 A;  1ZED A;  2W5Q A;  3NKR A;  1HDH A;  4UPK A;  1ED8 A;  3TWZ A;  4TN0 A;  1HJK A;  1ANI A;  1K7H A;  5EGH A;  3WAW A;  1EW8 A;  4MHX A;  4CYR A;  1EI6 A;  5HRT A;  5L0E A;  1AJB A;  3BDG A;  2D1G A;  3BDH A;  4UOO A;  3UN3 A;  1URA A;  1N2K A;  4ZG9 A;  4UOR A;  5DLW A;  3UNY A;  3T00 A;  4ZGA A;  3TX0 A;  2W8D A;  1O99 A;  3NKO A;  4UPL A;  4ZG7 A;  1N2L A;  2GSO A;  1Y7A A;  5IJS A;  3LXQ A;  4KAY A;  5LRM A;  2GA3 A;  1ED9 A;  2W5X A;  1ALK A;  3DPC A;  1E3C P;  1ZEB A;  1ELZ A;  2W5V A;  3Q3Q A;  4LR8 A;  3ED4 A;  1ALI A;  4GTW A;  1O98 A;  5TJ3 A;  3SZY A;  2GSN A;  4CXU A; 
#chains in the Genus database with same CATH homology
 1KH9 A;  3M8Y A;  3WAV A;  3MK1 A;  4GTZ A;  2ZKT A;  1KHK A;  1KHN A;  4LRC A;  5EGE A;  5INH A;  3WBH A;  1E33 P;  1P49 A;  1KH5 A;  2G9Y A;  4MIV A;  2W5R A;  3KD8 A;  1AJC A;  3DYC A;  4FDJ A;  4LRD A;  4N7T A;  3BDF A;  3B5Q A;  1ELX A;  1AJA A;  3UN2 A;  1FSU A;  3UN5 A;  1HQA A;  4LRA A;  4CXK A;  4YR1 A;  3A52 A;  1EJJ A;  4LQY A;  2IUC A;  3IGZ B;  3NKN A;  1KH4 A;  2W8S A;  3TG0 A;  4KAV A;  4NWJ A;  5IJQ A;  3M8Z A;  5LQQ A;  2VQR A;  4LR2 A;  1KH7 A;  1ALH A;  1E1Z P;  4GTY A;  4UPH A;  3UO0 A;  4KM4 A;  4FDI A;  3BDG B;  3NKP A;  5GRR A;  1KHJ A;  4MY4 A;  4CXS A;  1ZEF A;  4KJG A;  4GTX A;  4KJD A;  3T02 A;  5L0B A;  2RH6 A;  4B56 A;  5LRN A;  3NVL A;  1ELY A;  3MK2 A;  1EW9 A;  2IFY A;  3SZZ A;  3E2D A;  1URB A;  5LIA A;  1ALJ A;  1EW2 A;  4NWX A;  3IGY B;  3WAY A;  2GLQ A;  3T01 A;  2W5S A;  2W5W A;  4LR7 A;  3IDD A;  5AJ9 A;  1SHQ A;  5DLV A;  2GSU A;  1AUK A;  2W5T A;  3OT9 A;  1AJD A;  4LRF A;  2IUC B;  4LRE A;  1SHN A;  5KXA A;  5L0K A;  2XRG A;  1KHL A;  4UPI A;  4CYS A;  2QZU A;  3NKM A;  5K4P A;  4QAX A;  2ANH A;  3MK0 A;  3NKQ A;  1E2S P;  4LR9 A;  5GOV A;  3M7V A;  1B8J A;  4UOP A;  1ANJ A;  2X98 A;  4LRB A;  1Y6V A;  3M8W A;  5C66 A;  5DLT A;  3WAX A;  1EQJ A;  2XR9 A;  3CMR A;  4ZG6 A;  1ZED A;  2W5Q A;  3NKR A;  1HDH A;  4UPK A;  1ED8 A;  3TWZ A;  4TN0 A;  1HJK A;  1ANI A;  1K7H A;  5EGH A;  3WAW A;  1EW8 A;  4MHX A;  4CYR A;  1EI6 A;  5HRT A;  5L0E A;  1AJB A;  3BDG A;  2D1G A;  3BDH A;  4UOO A;  3UN3 A;  1URA A;  1N2K A;  4ZG9 A;  4UOR A;  5DLW A;  3UNY A;  3T00 A;  4ZGA A;  3TX0 A;  2W8D A;  1O99 A;  3NKO A;  4UPL A;  4ZG7 A;  1N2L A;  2GSO A;  1Y7A A;  5IJS A;  3LXQ A;  4KAY A;  5LRM A;  2GA3 A;  1ED9 A;  2W5X A;  1ALK A;  3DPC A;  1E3C P;  1ZEB A;  1ELZ A;  2W5V A;  3Q3Q A;  4LR8 A;  3ED4 A;  1ALI A;  4GTW A;  1O98 A;  5TJ3 A;  3SZY A;  2GSN A;  4CXU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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