1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
4NWXA 1E2SP 1KHJA 4LRBA 5DLTA 3MK0A 5DLWA 4MY4A 3T01A 4UORA 1AJCA 1KH4A 4LRDA 5EGHA 4GTXA 4KAYA 1ELZA 3TX0A 1O98A 2W5SA 4MIVA 3IGZB 1HQAA 2G9YA 2GSNA 4CXUA 1ZEDA 4MHXA 3UN2A 1ALKA 2W5TA 1URAA 4LQYA 4ZG7A 4N7TA 5KXAA 4GTZA 3SZYA 1K7HA 3B5QA 5K4PA 5LQQA 3T02A 1ALHA 1KHKA 3BDGB 3WAYA 1HJKA 3DPCA 4KM4A 2W8DA 3BDFA 5EGEA 3T00A 2XR9A 4NWJA 3WAWA 3TG0A 4KAVA 4UPLA 4CXSA 1ED8A 5IJSA 1E3CP 4LREA 5DLVA 1FSUA 2GSOA 5TJ3A 4LRCA 4UPIA 1ALJA 1ELXA 2W5RA 1EQJA 1Y7AA 4YR1A 1AJBA 1SHNA 3BDHA 1SHQA 1KHLA 1N2LA 5INHA 1KHNA 2RH6A 2IUCB 3NVLA 5L0EA 3M8YA 3WBHA 4QAXA 1URBA 5LRMA 4LR7A 1EI6A 1O99A 2VQRA 1ELYA 2W5XA 1AJDA 3CMRA 4UPHA 3LXQA 3UNYA 4ZG6A 3MK1A 4UOPA 5GRRA 5LRNA 4ZGAA 1P49A 3A52A 4FDIA 3WAXA 3DYCA 1EW2A 3SZZA 3UN5A 4ZG9A 3NKNA 4LRAA 2GLQA 4LR8A 4CYRA 4CXKA 3NKPA 1EW9A 2XRGA 5IJQA 1ZEBA 3ED4A 2GSUA 3M7VA 3M8WA 2IFYA 3IGYB 3NKRA 1AJAA 1N2KA 3BDGA 1E1ZP 3IDDA 3MK2A 3NKMA 1KH7A 4LR2A 1KH5A 5L0KA 4KJGA 4FDJA 1Y6VA 5HRTA 1ALIA 2QZUA 4UPKA 4LR9A 3UN3A 4GTYA 1E33P 1ZEFA 1KH9A 5L0BA 1ANJA 2D1GA 2GA3A 4LRFA 4GTWA 3NKOA 5AJ9A 1ED9A 3KD8A 2ANHA 2W5WA 3NKQA 4TN0A 2W5QA 2X98A 3Q3QA 5GOVA 3WAVA 1EJJA 2ZKTA 1AUKA 4KJDA 2W8SA 4CYSA 2W5VA 4UOOA 2IUCA 5LIAA 4B56A 3TWZA 1HDHA 3M8ZA 1EW8A 1B8JA 3UO0A 1ANIA 3E2DA 3OT9A 5C66A
chains in the Genus database with same CATH superfamily
4NWXA 1E2SP 1KHJA 4LRBA 5DLTA 3MK0A 5DLWA 4MY4A 3T01A 4UORA 1AJCA 1KH4A 4LRDA 5EGHA 4GTXA 4KAYA 1ELZA 3TX0A 1O98A 2W5SA 4MIVA 3IGZB 1HQAA 2G9YA 2GSNA 4CXUA 1ZEDA 4MHXA 3UN2A 1ALKA 2W5TA 1URAA 4LQYA 4ZG7A 4N7TA 5KXAA 4GTZA 3SZYA 1K7HA 3B5QA 5K4PA 5LQQA 3T02A 1ALHA 1KHKA 3BDGB 3WAYA 1HJKA 3DPCA 4KM4A 2W8DA 3BDFA 5EGEA 3T00A 2XR9A 4NWJA 3WAWA 3TG0A 4KAVA 4UPLA 4CXSA 1ED8A 5IJSA 1E3CP 4LREA 5DLVA 1FSUA 2GSOA 5TJ3A 4LRCA 4UPIA 1ALJA 1ELXA 2W5RA 1EQJA 1Y7AA 4YR1A 1AJBA 1SHNA 3BDHA 1SHQA 1KHLA 1N2LA 5INHA 1KHNA 2RH6A 2IUCB 3NVLA 5L0EA 3M8YA 3WBHA 4QAXA 1URBA 5LRMA 4LR7A 1EI6A 1O99A 2VQRA 1ELYA 2W5XA 1AJDA 3CMRA 4UPHA 3LXQA 3UNYA 4ZG6A 3MK1A 4UOPA 5GRRA 5LRNA 4ZGAA 1P49A 3A52A 4FDIA 3WAXA 3DYCA 1EW2A 3SZZA 3UN5A 4ZG9A 3NKNA 4LRAA 2GLQA 4LR8A 4CYRA 4CXKA 3NKPA 1EW9A 2XRGA 5IJQA 1ZEBA 3ED4A 2GSUA 3M7VA 3M8WA 2IFYA 3IGYB 3NKRA 1AJAA 1N2KA 3BDGA 1E1ZP 3IDDA 3MK2A 3NKMA 1KH7A 4LR2A 1KH5A 5L0KA 4KJGA 4FDJA 1Y6VA 5HRTA 1ALIA 2QZUA 4UPKA 4LR9A 3UN3A 4GTYA 1E33P 1ZEFA 1KH9A 5L0BA 1ANJA 2D1GA 2GA3A 4LRFA 4GTWA 3NKOA 5AJ9A 1ED9A 3KD8A 2ANHA 2W5WA 3NKQA 4TN0A 2W5QA 2X98A 3Q3QA 5GOVA 3WAVA 1EJJA 2ZKTA 1AUKA 4KJDA 2W8SA 4CYSA 2W5VA 4UOOA 2IUCA 5LIAA 4B56A 3TWZA 1HDHA 3M8ZA 1EW8A 1B8JA 3UO0A 1ANIA 3E2DA 3OT9A 5C66A
chains in the Genus database with same CATH topology
4NWXA 1E2SP 1KHJA 4LRBA 5DLTA 3MK0A 5DLWA 4MY4A 3T01A 4UORA 1AJCA 1KH4A 4LRDA 5EGHA 4GTXA 4KAYA 1ELZA 3TX0A 1O98A 2W5SA 4MIVA 3IGZB 1HQAA 2G9YA 2GSNA 4CXUA 1ZEDA 4MHXA 3UN2A 1ALKA 2W5TA 1URAA 4LQYA 4ZG7A 4N7TA 5KXAA 4GTZA 3SZYA 1K7HA 3B5QA 5K4PA 5LQQA 3T02A 1ALHA 1KHKA 3BDGB 3WAYA 1HJKA 3DPCA 4KM4A 2W8DA 3BDFA 5EGEA 3T00A 2XR9A 4NWJA 3WAWA 3TG0A 4KAVA 4UPLA 4CXSA 1ED8A 5IJSA 1E3CP 4LREA 5DLVA 1FSUA 2GSOA 5TJ3A 4LRCA 4UPIA 1ALJA 1ELXA 2W5RA 1EQJA 1Y7AA 4YR1A 1AJBA 1SHNA 3BDHA 1SHQA 1KHLA 1N2LA 5INHA 1KHNA 2RH6A 2IUCB 3NVLA 5L0EA 3M8YA 3WBHA 4QAXA 1URBA 5LRMA 4LR7A 1EI6A 1O99A 2VQRA 1ELYA 2W5XA 1AJDA 3CMRA 4UPHA 3LXQA 3UNYA 4ZG6A 3MK1A 4UOPA 5GRRA 5LRNA 4ZGAA 1P49A 3A52A 4FDIA 3WAXA 3DYCA 1EW2A 3SZZA 3UN5A 4ZG9A 3NKNA 4LRAA 2GLQA 4LR8A 4CYRA 4CXKA 3NKPA 1EW9A 2XRGA 5IJQA 1ZEBA 3ED4A 2GSUA 3M7VA 3M8WA 2IFYA 3IGYB 3NKRA 1AJAA 1N2KA 3BDGA 1E1ZP 3IDDA 3MK2A 3NKMA 1KH7A 4LR2A 1KH5A 5L0KA 4KJGA 4FDJA 1Y6VA 5HRTA 1ALIA 2QZUA 4UPKA 4LR9A 3UN3A 4GTYA 1E33P 1ZEFA 1KH9A 5L0BA 1ANJA 2D1GA 2GA3A 4LRFA 4GTWA 3NKOA 5AJ9A 1ED9A 3KD8A 2ANHA 2W5WA 3NKQA 4TN0A 2W5QA 2X98A 3Q3QA 5GOVA 3WAVA 1EJJA 2ZKTA 1AUKA 4KJDA 2W8SA 4CYSA 2W5VA 4UOOA 2IUCA 5LIAA 4B56A 3TWZA 1HDHA 3M8ZA 1EW8A 1B8JA 3UO0A 1ANIA 3E2DA 3OT9A 5C66A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NWX A;  1E2S P;  1KHJ A;  4LRB A;  5DLT A;  3MK0 A;  5DLW A;  4MY4 A;  3T01 A;  4UOR A;  1AJC A;  1KH4 A;  4LRD A;  5EGH A;  4GTX A;  4KAY A;  1ELZ A;  3TX0 A;  1O98 A;  2W5S A;  4MIV A;  3IGZ B;  1HQA A;  2G9Y A;  2GSN A;  4CXU A;  1ZED A;  4MHX A;  3UN2 A;  1ALK A;  2W5T A;  1URA A;  4LQY A;  4ZG7 A;  4N7T A;  5KXA A;  4GTZ A;  3SZY A;  1K7H A;  3B5Q A;  5K4P A;  5LQQ A;  3T02 A;  1ALH A;  1KHK A;  3BDG B;  3WAY A;  1HJK A;  3DPC A;  4KM4 A;  2W8D A;  3BDF A;  5EGE A;  3T00 A;  2XR9 A;  4NWJ A;  3WAW A;  3TG0 A;  4KAV A;  4UPL A;  4CXS A;  1ED8 A;  5IJS A;  1E3C P;  4LRE A;  5DLV A;  1FSU A;  2GSO A;  5TJ3 A;  4LRC A;  4UPI A;  1ALJ A;  1ELX A;  2W5R A;  1EQJ A;  1Y7A A;  4YR1 A;  1AJB A;  1SHN A;  3BDH A;  1SHQ A;  1KHL A;  1N2L A;  5INH A;  1KHN A;  2RH6 A;  2IUC B;  3NVL A;  5L0E A;  3M8Y A;  3WBH A;  4QAX A;  1URB A;  5LRM A;  4LR7 A;  1EI6 A;  1O99 A;  2VQR A;  1ELY A;  2W5X A;  1AJD A;  3CMR A;  4UPH A;  3LXQ A;  3UNY A;  4ZG6 A;  3MK1 A;  4UOP A;  5GRR A;  5LRN A;  4ZGA A;  1P49 A;  3A52 A;  4FDI A;  3WAX A;  3DYC A;  1EW2 A;  3SZZ A;  3UN5 A;  4ZG9 A;  3NKN A;  4LRA A;  2GLQ A;  4LR8 A;  4CYR A;  4CXK A;  3NKP A;  1EW9 A;  2XRG A;  5IJQ A;  1ZEB A;  3ED4 A;  2GSU A;  3M7V A;  3M8W A;  2IFY A;  3IGY B;  3NKR A;  1AJA A;  1N2K A;  3BDG A;  1E1Z P;  3IDD A;  3MK2 A;  3NKM A;  1KH7 A;  4LR2 A;  1KH5 A;  5L0K A;  4KJG A;  4FDJ A;  1Y6V A;  5HRT A;  1ALI A;  2QZU A;  4UPK A;  4LR9 A;  3UN3 A;  4GTY A;  1E33 P;  1ZEF A;  1KH9 A;  5L0B A;  1ANJ A;  2D1G A;  2GA3 A;  4LRF A;  4GTW A;  3NKO A;  5AJ9 A;  1ED9 A;  3KD8 A;  2ANH A;  2W5W A;  3NKQ A;  4TN0 A;  2W5Q A;  2X98 A;  3Q3Q A;  5GOV A;  3WAV A;  1EJJ A;  2ZKT A;  1AUK A;  4KJD A;  2W8S A;  4CYS A;  2W5V A;  4UOO A;  2IUC A;  5LIA A;  4B56 A;  3TWZ A;  1HDH A;  3M8Z A;  1EW8 A;  1B8J A;  3UO0 A;  1ANI A;  3E2D A;  3OT9 A;  5C66 A; 
#chains in the Genus database with same CATH topology
 4NWX A;  1E2S P;  1KHJ A;  4LRB A;  5DLT A;  3MK0 A;  5DLW A;  4MY4 A;  3T01 A;  4UOR A;  1AJC A;  1KH4 A;  4LRD A;  5EGH A;  4GTX A;  4KAY A;  1ELZ A;  3TX0 A;  1O98 A;  2W5S A;  4MIV A;  3IGZ B;  1HQA A;  2G9Y A;  2GSN A;  4CXU A;  1ZED A;  4MHX A;  3UN2 A;  1ALK A;  2W5T A;  1URA A;  4LQY A;  4ZG7 A;  4N7T A;  5KXA A;  4GTZ A;  3SZY A;  1K7H A;  3B5Q A;  5K4P A;  5LQQ A;  3T02 A;  1ALH A;  1KHK A;  3BDG B;  3WAY A;  1HJK A;  3DPC A;  4KM4 A;  2W8D A;  3BDF A;  5EGE A;  3T00 A;  2XR9 A;  4NWJ A;  3WAW A;  3TG0 A;  4KAV A;  4UPL A;  4CXS A;  1ED8 A;  5IJS A;  1E3C P;  4LRE A;  5DLV A;  1FSU A;  2GSO A;  5TJ3 A;  4LRC A;  4UPI A;  1ALJ A;  1ELX A;  2W5R A;  1EQJ A;  1Y7A A;  4YR1 A;  1AJB A;  1SHN A;  3BDH A;  1SHQ A;  1KHL A;  1N2L A;  5INH A;  1KHN A;  2RH6 A;  2IUC B;  3NVL A;  5L0E A;  3M8Y A;  3WBH A;  4QAX A;  1URB A;  5LRM A;  4LR7 A;  1EI6 A;  1O99 A;  2VQR A;  1ELY A;  2W5X A;  1AJD A;  3CMR A;  4UPH A;  3LXQ A;  3UNY A;  4ZG6 A;  3MK1 A;  4UOP A;  5GRR A;  5LRN A;  4ZGA A;  1P49 A;  3A52 A;  4FDI A;  3WAX A;  3DYC A;  1EW2 A;  3SZZ A;  3UN5 A;  4ZG9 A;  3NKN A;  4LRA A;  2GLQ A;  4LR8 A;  4CYR A;  4CXK A;  3NKP A;  1EW9 A;  2XRG A;  5IJQ A;  1ZEB A;  3ED4 A;  2GSU A;  3M7V A;  3M8W A;  2IFY A;  3IGY B;  3NKR A;  1AJA A;  1N2K A;  3BDG A;  1E1Z P;  3IDD A;  3MK2 A;  3NKM A;  1KH7 A;  4LR2 A;  1KH5 A;  5L0K A;  4KJG A;  4FDJ A;  1Y6V A;  5HRT A;  1ALI A;  2QZU A;  4UPK A;  4LR9 A;  3UN3 A;  4GTY A;  1E33 P;  1ZEF A;  1KH9 A;  5L0B A;  1ANJ A;  2D1G A;  2GA3 A;  4LRF A;  4GTW A;  3NKO A;  5AJ9 A;  1ED9 A;  3KD8 A;  2ANH A;  2W5W A;  3NKQ A;  4TN0 A;  2W5Q A;  2X98 A;  3Q3Q A;  5GOV A;  3WAV A;  1EJJ A;  2ZKT A;  1AUK A;  4KJD A;  2W8S A;  4CYS A;  2W5V A;  4UOO A;  2IUC A;  5LIA A;  4B56 A;  3TWZ A;  1HDH A;  3M8Z A;  1EW8 A;  1B8J A;  3UO0 A;  1ANI A;  3E2D A;  3OT9 A;  5C66 A; 
#chains in the Genus database with same CATH homology
 4NWX A;  1E2S P;  1KHJ A;  4LRB A;  5DLT A;  3MK0 A;  5DLW A;  4MY4 A;  3T01 A;  4UOR A;  1AJC A;  1KH4 A;  4LRD A;  5EGH A;  4GTX A;  4KAY A;  1ELZ A;  3TX0 A;  1O98 A;  2W5S A;  4MIV A;  3IGZ B;  1HQA A;  2G9Y A;  2GSN A;  4CXU A;  1ZED A;  4MHX A;  3UN2 A;  1ALK A;  2W5T A;  1URA A;  4LQY A;  4ZG7 A;  4N7T A;  5KXA A;  4GTZ A;  3SZY A;  1K7H A;  3B5Q A;  5K4P A;  5LQQ A;  3T02 A;  1ALH A;  1KHK A;  3BDG B;  3WAY A;  1HJK A;  3DPC A;  4KM4 A;  2W8D A;  3BDF A;  5EGE A;  3T00 A;  2XR9 A;  4NWJ A;  3WAW A;  3TG0 A;  4KAV A;  4UPL A;  4CXS A;  1ED8 A;  5IJS A;  1E3C P;  4LRE A;  5DLV A;  1FSU A;  2GSO A;  5TJ3 A;  4LRC A;  4UPI A;  1ALJ A;  1ELX A;  2W5R A;  1EQJ A;  1Y7A A;  4YR1 A;  1AJB A;  1SHN A;  3BDH A;  1SHQ A;  1KHL A;  1N2L A;  5INH A;  1KHN A;  2RH6 A;  2IUC B;  3NVL A;  5L0E A;  3M8Y A;  3WBH A;  4QAX A;  1URB A;  5LRM A;  4LR7 A;  1EI6 A;  1O99 A;  2VQR A;  1ELY A;  2W5X A;  1AJD A;  3CMR A;  4UPH A;  3LXQ A;  3UNY A;  4ZG6 A;  3MK1 A;  4UOP A;  5GRR A;  5LRN A;  4ZGA A;  1P49 A;  3A52 A;  4FDI A;  3WAX A;  3DYC A;  1EW2 A;  3SZZ A;  3UN5 A;  4ZG9 A;  3NKN A;  4LRA A;  2GLQ A;  4LR8 A;  4CYR A;  4CXK A;  3NKP A;  1EW9 A;  2XRG A;  5IJQ A;  1ZEB A;  3ED4 A;  2GSU A;  3M7V A;  3M8W A;  2IFY A;  3IGY B;  3NKR A;  1AJA A;  1N2K A;  3BDG A;  1E1Z P;  3IDD A;  3MK2 A;  3NKM A;  1KH7 A;  4LR2 A;  1KH5 A;  5L0K A;  4KJG A;  4FDJ A;  1Y6V A;  5HRT A;  1ALI A;  2QZU A;  4UPK A;  4LR9 A;  3UN3 A;  4GTY A;  1E33 P;  1ZEF A;  1KH9 A;  5L0B A;  1ANJ A;  2D1G A;  2GA3 A;  4LRF A;  4GTW A;  3NKO A;  5AJ9 A;  1ED9 A;  3KD8 A;  2ANH A;  2W5W A;  3NKQ A;  4TN0 A;  2W5Q A;  2X98 A;  3Q3Q A;  5GOV A;  3WAV A;  1EJJ A;  2ZKT A;  1AUK A;  4KJD A;  2W8S A;  4CYS A;  2W5V A;  4UOO A;  2IUC A;  5LIA A;  4B56 A;  3TWZ A;  1HDH A;  3M8Z A;  1EW8 A;  1B8J A;  3UO0 A;  1ANI A;  3E2D A;  3OT9 A;  5C66 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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