1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
3BDFA 4NWXA 3MK0A 1E2SP 1KH7A 1HQAA 1KHKA 1URBA 2D1GA 3TX0A 2G9YA 1EW8A 4LR9A 4LR2A 1N2KA 4UOOA 4UOPA 3UN2A 4TN0A 1KHNA 5TJ3A 1O99A 3CMRA 5IJQA 1ANIA 2X98A 1ED8A 2W5RA 4LREA 5IJSA 3NKMA 1URAA 1ALKA 4UPHA 1ELXA 3UNYA 1HJKA 3ED4A 4FDIA 4ZG7A 4QAXA 4UORA 4CYSA 5L0EA 1AJDA 3NKQA 4CYRA 4ZGAA 3M8YA 3UO0A 5INHA 1ALJA 3T02A 2RH6A 2W8DA 5DLVA 3BDHA 3BDGA 1K7HA 2W8SA 4KJDA 1EW2A 3Q3QA 3DPCA 3DYCA 4B56A 1HDHA 5L0BA 5EGHA 2W5QA 5LRNA 5GOVA 1AJCA 4ZG9A 1ED9A 1E3CP 3BDGB 1EQJA 3IGYB 5HRTA 5K4PA 3M7VA 2IUCB 2ZKTA 3NKOA 2GA3A 3B5QA 3WAVA 1ANJA 4NWJA 1O98A 4ZG6A 3WAWA 3A52A 2QZUA 2GSUA 2W5SA 5L0KA 3UN5A 3TG0A 4LQYA 5LRMA 3SZYA 1KH5A 2IFYA 4LRBA 5C66A 1EW9A 3T00A 2GSNA 4LR7A 3M8ZA 1ELYA 3IDDA 1ALHA 4LRFA 4MIVA 3IGZB 3SZZA 2VQRA 4GTWA 1Y6VA 4CXSA 5KXAA 1AJAA 2W5VA 1AUKA 1N2LA 1KHLA 4FDJA 2W5XA 4LRDA 1KH4A 1E33P 3M8WA 1ELZA 3NKPA 1Y7AA 4GTZA 1SHNA 4GTXA 1ZEBA 1KH9A 3WAYA 4LRCA 1ZEDA 4GTYA 3MK2A 4UPLA 3WAXA 1KHJA 2W5TA 3NVLA 1SHQA 3OT9A 1ZEFA 5DLWA 1EI6A 5DLTA 3TWZA 4N7TA 4KM4A 1E1ZP 3KD8A 4CXUA 1ALIA 5GRRA 1P49A 2W5WA 3E2DA 5EGEA 1EJJA 4MY4A 2IUCA 3MK1A 3NKNA 2ANHA 2XRGA 4UPKA 2XR9A 1FSUA 4YR1A 4LR8A 4KJGA 3WBHA 4CXKA 3UN3A 5LIAA 4MHXA 3NKRA 2GLQA 5AJ9A 3LXQA 1B8JA 4KAYA 4KAVA 4LRAA 4UPIA 1AJBA 3T01A 2GSOA 5LQQA
chains in the Genus database with same CATH superfamily
3BDFA 4NWXA 3MK0A 1E2SP 1KH7A 1HQAA 1KHKA 1URBA 2D1GA 3TX0A 2G9YA 1EW8A 4LR9A 4LR2A 1N2KA 4UOOA 4UOPA 3UN2A 4TN0A 1KHNA 5TJ3A 1O99A 3CMRA 5IJQA 1ANIA 2X98A 1ED8A 2W5RA 4LREA 5IJSA 3NKMA 1URAA 1ALKA 4UPHA 1ELXA 3UNYA 1HJKA 3ED4A 4FDIA 4ZG7A 4QAXA 4UORA 4CYSA 5L0EA 1AJDA 3NKQA 4CYRA 4ZGAA 3M8YA 3UO0A 5INHA 1ALJA 3T02A 2RH6A 2W8DA 5DLVA 3BDHA 3BDGA 1K7HA 2W8SA 4KJDA 1EW2A 3Q3QA 3DPCA 3DYCA 4B56A 1HDHA 5L0BA 5EGHA 2W5QA 5LRNA 5GOVA 1AJCA 4ZG9A 1ED9A 1E3CP 3BDGB 1EQJA 3IGYB 5HRTA 5K4PA 3M7VA 2IUCB 2ZKTA 3NKOA 2GA3A 3B5QA 3WAVA 1ANJA 4NWJA 1O98A 4ZG6A 3WAWA 3A52A 2QZUA 2GSUA 2W5SA 5L0KA 3UN5A 3TG0A 4LQYA 5LRMA 3SZYA 1KH5A 2IFYA 4LRBA 5C66A 1EW9A 3T00A 2GSNA 4LR7A 3M8ZA 1ELYA 3IDDA 1ALHA 4LRFA 4MIVA 3IGZB 3SZZA 2VQRA 4GTWA 1Y6VA 4CXSA 5KXAA 1AJAA 2W5VA 1AUKA 1N2LA 1KHLA 4FDJA 2W5XA 4LRDA 1KH4A 1E33P 3M8WA 1ELZA 3NKPA 1Y7AA 4GTZA 1SHNA 4GTXA 1ZEBA 1KH9A 3WAYA 4LRCA 1ZEDA 4GTYA 3MK2A 4UPLA 3WAXA 1KHJA 2W5TA 3NVLA 1SHQA 3OT9A 1ZEFA 5DLWA 1EI6A 5DLTA 3TWZA 4N7TA 4KM4A 1E1ZP 3KD8A 4CXUA 1ALIA 5GRRA 1P49A 2W5WA 3E2DA 5EGEA 1EJJA 4MY4A 2IUCA 3MK1A 3NKNA 2ANHA 2XRGA 4UPKA 2XR9A 1FSUA 4YR1A 4LR8A 4KJGA 3WBHA 4CXKA 3UN3A 5LIAA 4MHXA 3NKRA 2GLQA 5AJ9A 3LXQA 1B8JA 4KAYA 4KAVA 4LRAA 4UPIA 1AJBA 3T01A 2GSOA 5LQQA
chains in the Genus database with same CATH topology
3BDFA 4NWXA 3MK0A 1E2SP 1KH7A 1HQAA 1KHKA 1URBA 2D1GA 3TX0A 2G9YA 1EW8A 4LR9A 4LR2A 1N2KA 4UOOA 4UOPA 3UN2A 4TN0A 1KHNA 5TJ3A 1O99A 3CMRA 5IJQA 1ANIA 2X98A 1ED8A 2W5RA 4LREA 5IJSA 3NKMA 1URAA 1ALKA 4UPHA 1ELXA 3UNYA 1HJKA 3ED4A 4FDIA 4ZG7A 4QAXA 4UORA 4CYSA 5L0EA 1AJDA 3NKQA 4CYRA 4ZGAA 3M8YA 3UO0A 5INHA 1ALJA 3T02A 2RH6A 2W8DA 5DLVA 3BDHA 3BDGA 1K7HA 2W8SA 4KJDA 1EW2A 3Q3QA 3DPCA 3DYCA 4B56A 1HDHA 5L0BA 5EGHA 2W5QA 5LRNA 5GOVA 1AJCA 4ZG9A 1ED9A 1E3CP 3BDGB 1EQJA 3IGYB 5HRTA 5K4PA 3M7VA 2IUCB 2ZKTA 3NKOA 2GA3A 3B5QA 3WAVA 1ANJA 4NWJA 1O98A 4ZG6A 3WAWA 3A52A 2QZUA 2GSUA 2W5SA 5L0KA 3UN5A 3TG0A 4LQYA 5LRMA 3SZYA 1KH5A 2IFYA 4LRBA 5C66A 1EW9A 3T00A 2GSNA 4LR7A 3M8ZA 1ELYA 3IDDA 1ALHA 4LRFA 4MIVA 3IGZB 3SZZA 2VQRA 4GTWA 1Y6VA 4CXSA 5KXAA 1AJAA 2W5VA 1AUKA 1N2LA 1KHLA 4FDJA 2W5XA 4LRDA 1KH4A 1E33P 3M8WA 1ELZA 3NKPA 1Y7AA 4GTZA 1SHNA 4GTXA 1ZEBA 1KH9A 3WAYA 4LRCA 1ZEDA 4GTYA 3MK2A 4UPLA 3WAXA 1KHJA 2W5TA 3NVLA 1SHQA 3OT9A 1ZEFA 5DLWA 1EI6A 5DLTA 3TWZA 4N7TA 4KM4A 1E1ZP 3KD8A 4CXUA 1ALIA 5GRRA 1P49A 2W5WA 3E2DA 5EGEA 1EJJA 4MY4A 2IUCA 3MK1A 3NKNA 2ANHA 2XRGA 4UPKA 2XR9A 1FSUA 4YR1A 4LR8A 4KJGA 3WBHA 4CXKA 3UN3A 5LIAA 4MHXA 3NKRA 2GLQA 5AJ9A 3LXQA 1B8JA 4KAYA 4KAVA 4LRAA 4UPIA 1AJBA 3T01A 2GSOA 5LQQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BDF A;  4NWX A;  3MK0 A;  1E2S P;  1KH7 A;  1HQA A;  1KHK A;  1URB A;  2D1G A;  3TX0 A;  2G9Y A;  1EW8 A;  4LR9 A;  4LR2 A;  1N2K A;  4UOO A;  4UOP A;  3UN2 A;  4TN0 A;  1KHN A;  5TJ3 A;  1O99 A;  3CMR A;  5IJQ A;  1ANI A;  2X98 A;  1ED8 A;  2W5R A;  4LRE A;  5IJS A;  3NKM A;  1URA A;  1ALK A;  4UPH A;  1ELX A;  3UNY A;  1HJK A;  3ED4 A;  4FDI A;  4ZG7 A;  4QAX A;  4UOR A;  4CYS A;  5L0E A;  1AJD A;  3NKQ A;  4CYR A;  4ZGA A;  3M8Y A;  3UO0 A;  5INH A;  1ALJ A;  3T02 A;  2RH6 A;  2W8D A;  5DLV A;  3BDH A;  3BDG A;  1K7H A;  2W8S A;  4KJD A;  1EW2 A;  3Q3Q A;  3DPC A;  3DYC A;  4B56 A;  1HDH A;  5L0B A;  5EGH A;  2W5Q A;  5LRN A;  5GOV A;  1AJC A;  4ZG9 A;  1ED9 A;  1E3C P;  3BDG B;  1EQJ A;  3IGY B;  5HRT A;  5K4P A;  3M7V A;  2IUC B;  2ZKT A;  3NKO A;  2GA3 A;  3B5Q A;  3WAV A;  1ANJ A;  4NWJ A;  1O98 A;  4ZG6 A;  3WAW A;  3A52 A;  2QZU A;  2GSU A;  2W5S A;  5L0K A;  3UN5 A;  3TG0 A;  4LQY A;  5LRM A;  3SZY A;  1KH5 A;  2IFY A;  4LRB A;  5C66 A;  1EW9 A;  3T00 A;  2GSN A;  4LR7 A;  3M8Z A;  1ELY A;  3IDD A;  1ALH A;  4LRF A;  4MIV A;  3IGZ B;  3SZZ A;  2VQR A;  4GTW A;  1Y6V A;  4CXS A;  5KXA A;  1AJA A;  2W5V A;  1AUK A;  1N2L A;  1KHL A;  4FDJ A;  2W5X A;  4LRD A;  1KH4 A;  1E33 P;  3M8W A;  1ELZ A;  3NKP A;  1Y7A A;  4GTZ A;  1SHN A;  4GTX A;  1ZEB A;  1KH9 A;  3WAY A;  4LRC A;  1ZED A;  4GTY A;  3MK2 A;  4UPL A;  3WAX A;  1KHJ A;  2W5T A;  3NVL A;  1SHQ A;  3OT9 A;  1ZEF A;  5DLW A;  1EI6 A;  5DLT A;  3TWZ A;  4N7T A;  4KM4 A;  1E1Z P;  3KD8 A;  4CXU A;  1ALI A;  5GRR A;  1P49 A;  2W5W A;  3E2D A;  5EGE A;  1EJJ A;  4MY4 A;  2IUC A;  3MK1 A;  3NKN A;  2ANH A;  2XRG A;  4UPK A;  2XR9 A;  1FSU A;  4YR1 A;  4LR8 A;  4KJG A;  3WBH A;  4CXK A;  3UN3 A;  5LIA A;  4MHX A;  3NKR A;  2GLQ A;  5AJ9 A;  3LXQ A;  1B8J A;  4KAY A;  4KAV A;  4LRA A;  4UPI A;  1AJB A;  3T01 A;  2GSO A;  5LQQ A; 
#chains in the Genus database with same CATH topology
 3BDF A;  4NWX A;  3MK0 A;  1E2S P;  1KH7 A;  1HQA A;  1KHK A;  1URB A;  2D1G A;  3TX0 A;  2G9Y A;  1EW8 A;  4LR9 A;  4LR2 A;  1N2K A;  4UOO A;  4UOP A;  3UN2 A;  4TN0 A;  1KHN A;  5TJ3 A;  1O99 A;  3CMR A;  5IJQ A;  1ANI A;  2X98 A;  1ED8 A;  2W5R A;  4LRE A;  5IJS A;  3NKM A;  1URA A;  1ALK A;  4UPH A;  1ELX A;  3UNY A;  1HJK A;  3ED4 A;  4FDI A;  4ZG7 A;  4QAX A;  4UOR A;  4CYS A;  5L0E A;  1AJD A;  3NKQ A;  4CYR A;  4ZGA A;  3M8Y A;  3UO0 A;  5INH A;  1ALJ A;  3T02 A;  2RH6 A;  2W8D A;  5DLV A;  3BDH A;  3BDG A;  1K7H A;  2W8S A;  4KJD A;  1EW2 A;  3Q3Q A;  3DPC A;  3DYC A;  4B56 A;  1HDH A;  5L0B A;  5EGH A;  2W5Q A;  5LRN A;  5GOV A;  1AJC A;  4ZG9 A;  1ED9 A;  1E3C P;  3BDG B;  1EQJ A;  3IGY B;  5HRT A;  5K4P A;  3M7V A;  2IUC B;  2ZKT A;  3NKO A;  2GA3 A;  3B5Q A;  3WAV A;  1ANJ A;  4NWJ A;  1O98 A;  4ZG6 A;  3WAW A;  3A52 A;  2QZU A;  2GSU A;  2W5S A;  5L0K A;  3UN5 A;  3TG0 A;  4LQY A;  5LRM A;  3SZY A;  1KH5 A;  2IFY A;  4LRB A;  5C66 A;  1EW9 A;  3T00 A;  2GSN A;  4LR7 A;  3M8Z A;  1ELY A;  3IDD A;  1ALH A;  4LRF A;  4MIV A;  3IGZ B;  3SZZ A;  2VQR A;  4GTW A;  1Y6V A;  4CXS A;  5KXA A;  1AJA A;  2W5V A;  1AUK A;  1N2L A;  1KHL A;  4FDJ A;  2W5X A;  4LRD A;  1KH4 A;  1E33 P;  3M8W A;  1ELZ A;  3NKP A;  1Y7A A;  4GTZ A;  1SHN A;  4GTX A;  1ZEB A;  1KH9 A;  3WAY A;  4LRC A;  1ZED A;  4GTY A;  3MK2 A;  4UPL A;  3WAX A;  1KHJ A;  2W5T A;  3NVL A;  1SHQ A;  3OT9 A;  1ZEF A;  5DLW A;  1EI6 A;  5DLT A;  3TWZ A;  4N7T A;  4KM4 A;  1E1Z P;  3KD8 A;  4CXU A;  1ALI A;  5GRR A;  1P49 A;  2W5W A;  3E2D A;  5EGE A;  1EJJ A;  4MY4 A;  2IUC A;  3MK1 A;  3NKN A;  2ANH A;  2XRG A;  4UPK A;  2XR9 A;  1FSU A;  4YR1 A;  4LR8 A;  4KJG A;  3WBH A;  4CXK A;  3UN3 A;  5LIA A;  4MHX A;  3NKR A;  2GLQ A;  5AJ9 A;  3LXQ A;  1B8J A;  4KAY A;  4KAV A;  4LRA A;  4UPI A;  1AJB A;  3T01 A;  2GSO A;  5LQQ A; 
#chains in the Genus database with same CATH homology
 3BDF A;  4NWX A;  3MK0 A;  1E2S P;  1KH7 A;  1HQA A;  1KHK A;  1URB A;  2D1G A;  3TX0 A;  2G9Y A;  1EW8 A;  4LR9 A;  4LR2 A;  1N2K A;  4UOO A;  4UOP A;  3UN2 A;  4TN0 A;  1KHN A;  5TJ3 A;  1O99 A;  3CMR A;  5IJQ A;  1ANI A;  2X98 A;  1ED8 A;  2W5R A;  4LRE A;  5IJS A;  3NKM A;  1URA A;  1ALK A;  4UPH A;  1ELX A;  3UNY A;  1HJK A;  3ED4 A;  4FDI A;  4ZG7 A;  4QAX A;  4UOR A;  4CYS A;  5L0E A;  1AJD A;  3NKQ A;  4CYR A;  4ZGA A;  3M8Y A;  3UO0 A;  5INH A;  1ALJ A;  3T02 A;  2RH6 A;  2W8D A;  5DLV A;  3BDH A;  3BDG A;  1K7H A;  2W8S A;  4KJD A;  1EW2 A;  3Q3Q A;  3DPC A;  3DYC A;  4B56 A;  1HDH A;  5L0B A;  5EGH A;  2W5Q A;  5LRN A;  5GOV A;  1AJC A;  4ZG9 A;  1ED9 A;  1E3C P;  3BDG B;  1EQJ A;  3IGY B;  5HRT A;  5K4P A;  3M7V A;  2IUC B;  2ZKT A;  3NKO A;  2GA3 A;  3B5Q A;  3WAV A;  1ANJ A;  4NWJ A;  1O98 A;  4ZG6 A;  3WAW A;  3A52 A;  2QZU A;  2GSU A;  2W5S A;  5L0K A;  3UN5 A;  3TG0 A;  4LQY A;  5LRM A;  3SZY A;  1KH5 A;  2IFY A;  4LRB A;  5C66 A;  1EW9 A;  3T00 A;  2GSN A;  4LR7 A;  3M8Z A;  1ELY A;  3IDD A;  1ALH A;  4LRF A;  4MIV A;  3IGZ B;  3SZZ A;  2VQR A;  4GTW A;  1Y6V A;  4CXS A;  5KXA A;  1AJA A;  2W5V A;  1AUK A;  1N2L A;  1KHL A;  4FDJ A;  2W5X A;  4LRD A;  1KH4 A;  1E33 P;  3M8W A;  1ELZ A;  3NKP A;  1Y7A A;  4GTZ A;  1SHN A;  4GTX A;  1ZEB A;  1KH9 A;  3WAY A;  4LRC A;  1ZED A;  4GTY A;  3MK2 A;  4UPL A;  3WAX A;  1KHJ A;  2W5T A;  3NVL A;  1SHQ A;  3OT9 A;  1ZEF A;  5DLW A;  1EI6 A;  5DLT A;  3TWZ A;  4N7T A;  4KM4 A;  1E1Z P;  3KD8 A;  4CXU A;  1ALI A;  5GRR A;  1P49 A;  2W5W A;  3E2D A;  5EGE A;  1EJJ A;  4MY4 A;  2IUC A;  3MK1 A;  3NKN A;  2ANH A;  2XRG A;  4UPK A;  2XR9 A;  1FSU A;  4YR1 A;  4LR8 A;  4KJG A;  3WBH A;  4CXK A;  3UN3 A;  5LIA A;  4MHX A;  3NKR A;  2GLQ A;  5AJ9 A;  3LXQ A;  1B8J A;  4KAY A;  4KAV A;  4LRA A;  4UPI A;  1AJB A;  3T01 A;  2GSO A;  5LQQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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