1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
b'TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ALKALINE PHOSPHATASE
publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Alkaline phosphatase
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
1E33P 3NKOA 1E2SP 2ZKTA 3BDFA 4KJDA 2RH6A 1N2LA 4YR1A 4UPHA 3T02A 4LRBA 4GTXA 3KD8A 1KH4A 4MIVA 4UORA 5LIAA 3UN2A 1KH5A 5LQQA 3MK0A 3M8YA 4CXUA 4KM4A 1ALKA 2W5SA 1B8JA 2GSNA 4MY4A 4LR7A 1ED8A 1AJDA 3TWZA 5L0BA 3BDGA 3WAWA 4FDIA 3NKMA 4LRCA 1EW8A 4UOPA 1ZEFA 3WBHA 3SZYA 4FDJA 1ANIA 3DYCA 5INHA 4UPLA 3T01A 4LR8A 1O98A 3BDGB 2XR9A 3NKPA 5DLVA 4LRAA 2GA3A 4KJGA 4CYSA 4B56A 5TJ3A 4ZG9A 1ZEBA 3M7VA 3TX0A 4N7TA 4KAVA 2GLQA 5HRTA 3M8ZA 1Y7AA 3ED4A 3DPCA 4ZG7A 4LR2A 2IFYA 5K4PA 1URBA 3CMRA 1EI6A 1URAA 4NWJA 5KXAA 3UNYA 4LR9A 2W8SA 5L0KA 3NKRA 4TN0A 3UN5A 5EGHA 5GRRA 2W5XA 3WAXA 2GSUA 2QZUA 3WAVA 1ANJA 5IJQA 1ELYA 2IUCA 4LQYA 2W5WA 1SHQA 1ALIA 5L0EA 2W5VA 4QAXA 4CXKA 3IDDA 2W5TA 2IUCB 1HQAA 1ALHA 1AUKA 4KAYA 4LRDA 5DLTA 1ED9A 1N2KA 2XRGA 2W5QA 4CXSA 3T00A 1Y6VA 1SHNA 3IGYB 3OT9A 3NKNA 2GSOA 4GTWA 4UPIA 2VQRA 3NKQA 1KHLA 4UPKA 5AJ9A 1ALJA 5DLWA 1KH9A 2D1GA 1E1ZP 3UO0A 3MK1A 3A52A 2X98A 1KH7A 1EJJA 1FSUA 3WAYA 3SZZA 4UOOA 3IGZB 4CYRA 3TG0A 1KHKA 1O99A 1KHJA 1EW9A 4MHXA 1K7HA 1E3CP 4ZGAA 1HJKA 3NVLA 1KHNA 5EGEA 3BDHA 2W5RA 4GTYA 3LXQA 1EQJA 3UN3A 1AJCA 1ZEDA 5LRNA 5LRMA 1EW2A 1HDHA 5IJSA 1AJAA 5C66A 3Q3QA 1AJBA 2G9YA 2ANHA 3MK2A 1ELZA 2W8DA 4LRFA 1ELXA 3E2DA 3M8WA 3B5QA 5GOVA 4ZG6A 1P49A 4GTZA 4LREA 4NWXA
chains in the Genus database with same CATH superfamily
1E33P 3NKOA 1E2SP 2ZKTA 3BDFA 4KJDA 2RH6A 1N2LA 4YR1A 4UPHA 3T02A 4LRBA 4GTXA 3KD8A 1KH4A 4MIVA 4UORA 5LIAA 3UN2A 1KH5A 5LQQA 3MK0A 3M8YA 4CXUA 4KM4A 1ALKA 2W5SA 1B8JA 2GSNA 4MY4A 4LR7A 1ED8A 1AJDA 3TWZA 5L0BA 3BDGA 3WAWA 4FDIA 3NKMA 4LRCA 1EW8A 4UOPA 1ZEFA 3WBHA 3SZYA 4FDJA 1ANIA 3DYCA 5INHA 4UPLA 3T01A 4LR8A 1O98A 3BDGB 2XR9A 3NKPA 5DLVA 4LRAA 2GA3A 4KJGA 4CYSA 4B56A 5TJ3A 4ZG9A 1ZEBA 3M7VA 3TX0A 4N7TA 4KAVA 2GLQA 5HRTA 3M8ZA 1Y7AA 3ED4A 3DPCA 4ZG7A 4LR2A 2IFYA 5K4PA 1URBA 3CMRA 1EI6A 1URAA 4NWJA 5KXAA 3UNYA 4LR9A 2W8SA 5L0KA 3NKRA 4TN0A 3UN5A 5EGHA 5GRRA 2W5XA 3WAXA 2GSUA 2QZUA 3WAVA 1ANJA 5IJQA 1ELYA 2IUCA 4LQYA 2W5WA 1SHQA 1ALIA 5L0EA 2W5VA 4QAXA 4CXKA 3IDDA 2W5TA 2IUCB 1HQAA 1ALHA 1AUKA 4KAYA 4LRDA 5DLTA 1ED9A 1N2KA 2XRGA 2W5QA 4CXSA 3T00A 1Y6VA 1SHNA 3IGYB 3OT9A 3NKNA 2GSOA 4GTWA 4UPIA 2VQRA 3NKQA 1KHLA 4UPKA 5AJ9A 1ALJA 5DLWA 1KH9A 2D1GA 1E1ZP 3UO0A 3MK1A 3A52A 2X98A 1KH7A 1EJJA 1FSUA 3WAYA 3SZZA 4UOOA 3IGZB 4CYRA 3TG0A 1KHKA 1O99A 1KHJA 1EW9A 4MHXA 1K7HA 1E3CP 4ZGAA 1HJKA 3NVLA 1KHNA 5EGEA 3BDHA 2W5RA 4GTYA 3LXQA 1EQJA 3UN3A 1AJCA 1ZEDA 5LRNA 5LRMA 1EW2A 1HDHA 5IJSA 1AJAA 5C66A 3Q3QA 1AJBA 2G9YA 2ANHA 3MK2A 1ELZA 2W8DA 4LRFA 1ELXA 3E2DA 3M8WA 3B5QA 5GOVA 4ZG6A 1P49A 4GTZA 4LREA 4NWXA
chains in the Genus database with same CATH topology
1E33P 3NKOA 1E2SP 2ZKTA 3BDFA 4KJDA 2RH6A 1N2LA 4YR1A 4UPHA 3T02A 4LRBA 4GTXA 3KD8A 1KH4A 4MIVA 4UORA 5LIAA 3UN2A 1KH5A 5LQQA 3MK0A 3M8YA 4CXUA 4KM4A 1ALKA 2W5SA 1B8JA 2GSNA 4MY4A 4LR7A 1ED8A 1AJDA 3TWZA 5L0BA 3BDGA 3WAWA 4FDIA 3NKMA 4LRCA 1EW8A 4UOPA 1ZEFA 3WBHA 3SZYA 4FDJA 1ANIA 3DYCA 5INHA 4UPLA 3T01A 4LR8A 1O98A 3BDGB 2XR9A 3NKPA 5DLVA 4LRAA 2GA3A 4KJGA 4CYSA 4B56A 5TJ3A 4ZG9A 1ZEBA 3M7VA 3TX0A 4N7TA 4KAVA 2GLQA 5HRTA 3M8ZA 1Y7AA 3ED4A 3DPCA 4ZG7A 4LR2A 2IFYA 5K4PA 1URBA 3CMRA 1EI6A 1URAA 4NWJA 5KXAA 3UNYA 4LR9A 2W8SA 5L0KA 3NKRA 4TN0A 3UN5A 5EGHA 5GRRA 2W5XA 3WAXA 2GSUA 2QZUA 3WAVA 1ANJA 5IJQA 1ELYA 2IUCA 4LQYA 2W5WA 1SHQA 1ALIA 5L0EA 2W5VA 4QAXA 4CXKA 3IDDA 2W5TA 2IUCB 1HQAA 1ALHA 1AUKA 4KAYA 4LRDA 5DLTA 1ED9A 1N2KA 2XRGA 2W5QA 4CXSA 3T00A 1Y6VA 1SHNA 3IGYB 3OT9A 3NKNA 2GSOA 4GTWA 4UPIA 2VQRA 3NKQA 1KHLA 4UPKA 5AJ9A 1ALJA 5DLWA 1KH9A 2D1GA 1E1ZP 3UO0A 3MK1A 3A52A 2X98A 1KH7A 1EJJA 1FSUA 3WAYA 3SZZA 4UOOA 3IGZB 4CYRA 3TG0A 1KHKA 1O99A 1KHJA 1EW9A 4MHXA 1K7HA 1E3CP 4ZGAA 1HJKA 3NVLA 1KHNA 5EGEA 3BDHA 2W5RA 4GTYA 3LXQA 1EQJA 3UN3A 1AJCA 1ZEDA 5LRNA 5LRMA 1EW2A 1HDHA 5IJSA 1AJAA 5C66A 3Q3QA 1AJBA 2G9YA 2ANHA 3MK2A 1ELZA 2W8DA 4LRFA 1ELXA 3E2DA 3M8WA 3B5QA 5GOVA 4ZG6A 1P49A 4GTZA 4LREA 4NWXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1E33 P;  3NKO A;  1E2S P;  2ZKT A;  3BDF A;  4KJD A;  2RH6 A;  1N2L A;  4YR1 A;  4UPH A;  3T02 A;  4LRB A;  4GTX A;  3KD8 A;  1KH4 A;  4MIV A;  4UOR A;  5LIA A;  3UN2 A;  1KH5 A;  5LQQ A;  3MK0 A;  3M8Y A;  4CXU A;  4KM4 A;  1ALK A;  2W5S A;  1B8J A;  2GSN A;  4MY4 A;  4LR7 A;  1ED8 A;  1AJD A;  3TWZ A;  5L0B A;  3BDG A;  3WAW A;  4FDI A;  3NKM A;  4LRC A;  1EW8 A;  4UOP A;  1ZEF A;  3WBH A;  3SZY A;  4FDJ A;  1ANI A;  3DYC A;  5INH A;  4UPL A;  3T01 A;  4LR8 A;  1O98 A;  3BDG B;  2XR9 A;  3NKP A;  5DLV A;  4LRA A;  2GA3 A;  4KJG A;  4CYS A;  4B56 A;  5TJ3 A;  4ZG9 A;  1ZEB A;  3M7V A;  3TX0 A;  4N7T A;  4KAV A;  2GLQ A;  5HRT A;  3M8Z A;  1Y7A A;  3ED4 A;  3DPC A;  4ZG7 A;  4LR2 A;  2IFY A;  5K4P A;  1URB A;  3CMR A;  1EI6 A;  1URA A;  4NWJ A;  5KXA A;  3UNY A;  4LR9 A;  2W8S A;  5L0K A;  3NKR A;  4TN0 A;  3UN5 A;  5EGH A;  5GRR A;  2W5X A;  3WAX A;  2GSU A;  2QZU A;  3WAV A;  1ANJ A;  5IJQ A;  1ELY A;  2IUC A;  4LQY A;  2W5W A;  1SHQ A;  1ALI A;  5L0E A;  2W5V A;  4QAX A;  4CXK A;  3IDD A;  2W5T A;  2IUC B;  1HQA A;  1ALH A;  1AUK A;  4KAY A;  4LRD A;  5DLT A;  1ED9 A;  1N2K A;  2XRG A;  2W5Q A;  4CXS A;  3T00 A;  1Y6V A;  1SHN A;  3IGY B;  3OT9 A;  3NKN A;  2GSO A;  4GTW A;  4UPI A;  2VQR A;  3NKQ A;  1KHL A;  4UPK A;  5AJ9 A;  1ALJ A;  5DLW A;  1KH9 A;  2D1G A;  1E1Z P;  3UO0 A;  3MK1 A;  3A52 A;  2X98 A;  1KH7 A;  1EJJ A;  1FSU A;  3WAY A;  3SZZ A;  4UOO A;  3IGZ B;  4CYR A;  3TG0 A;  1KHK A;  1O99 A;  1KHJ A;  1EW9 A;  4MHX A;  1K7H A;  1E3C P;  4ZGA A;  1HJK A;  3NVL A;  1KHN A;  5EGE A;  3BDH A;  2W5R A;  4GTY A;  3LXQ A;  1EQJ A;  3UN3 A;  1AJC A;  1ZED A;  5LRN A;  5LRM A;  1EW2 A;  1HDH A;  5IJS A;  1AJA A;  5C66 A;  3Q3Q A;  1AJB A;  2G9Y A;  2ANH A;  3MK2 A;  1ELZ A;  2W8D A;  4LRF A;  1ELX A;  3E2D A;  3M8W A;  3B5Q A;  5GOV A;  4ZG6 A;  1P49 A;  4GTZ A;  4LRE A;  4NWX A; 
#chains in the Genus database with same CATH topology
 1E33 P;  3NKO A;  1E2S P;  2ZKT A;  3BDF A;  4KJD A;  2RH6 A;  1N2L A;  4YR1 A;  4UPH A;  3T02 A;  4LRB A;  4GTX A;  3KD8 A;  1KH4 A;  4MIV A;  4UOR A;  5LIA A;  3UN2 A;  1KH5 A;  5LQQ A;  3MK0 A;  3M8Y A;  4CXU A;  4KM4 A;  1ALK A;  2W5S A;  1B8J A;  2GSN A;  4MY4 A;  4LR7 A;  1ED8 A;  1AJD A;  3TWZ A;  5L0B A;  3BDG A;  3WAW A;  4FDI A;  3NKM A;  4LRC A;  1EW8 A;  4UOP A;  1ZEF A;  3WBH A;  3SZY A;  4FDJ A;  1ANI A;  3DYC A;  5INH A;  4UPL A;  3T01 A;  4LR8 A;  1O98 A;  3BDG B;  2XR9 A;  3NKP A;  5DLV A;  4LRA A;  2GA3 A;  4KJG A;  4CYS A;  4B56 A;  5TJ3 A;  4ZG9 A;  1ZEB A;  3M7V A;  3TX0 A;  4N7T A;  4KAV A;  2GLQ A;  5HRT A;  3M8Z A;  1Y7A A;  3ED4 A;  3DPC A;  4ZG7 A;  4LR2 A;  2IFY A;  5K4P A;  1URB A;  3CMR A;  1EI6 A;  1URA A;  4NWJ A;  5KXA A;  3UNY A;  4LR9 A;  2W8S A;  5L0K A;  3NKR A;  4TN0 A;  3UN5 A;  5EGH A;  5GRR A;  2W5X A;  3WAX A;  2GSU A;  2QZU A;  3WAV A;  1ANJ A;  5IJQ A;  1ELY A;  2IUC A;  4LQY A;  2W5W A;  1SHQ A;  1ALI A;  5L0E A;  2W5V A;  4QAX A;  4CXK A;  3IDD A;  2W5T A;  2IUC B;  1HQA A;  1ALH A;  1AUK A;  4KAY A;  4LRD A;  5DLT A;  1ED9 A;  1N2K A;  2XRG A;  2W5Q A;  4CXS A;  3T00 A;  1Y6V A;  1SHN A;  3IGY B;  3OT9 A;  3NKN A;  2GSO A;  4GTW A;  4UPI A;  2VQR A;  3NKQ A;  1KHL A;  4UPK A;  5AJ9 A;  1ALJ A;  5DLW A;  1KH9 A;  2D1G A;  1E1Z P;  3UO0 A;  3MK1 A;  3A52 A;  2X98 A;  1KH7 A;  1EJJ A;  1FSU A;  3WAY A;  3SZZ A;  4UOO A;  3IGZ B;  4CYR A;  3TG0 A;  1KHK A;  1O99 A;  1KHJ A;  1EW9 A;  4MHX A;  1K7H A;  1E3C P;  4ZGA A;  1HJK A;  3NVL A;  1KHN A;  5EGE A;  3BDH A;  2W5R A;  4GTY A;  3LXQ A;  1EQJ A;  3UN3 A;  1AJC A;  1ZED A;  5LRN A;  5LRM A;  1EW2 A;  1HDH A;  5IJS A;  1AJA A;  5C66 A;  3Q3Q A;  1AJB A;  2G9Y A;  2ANH A;  3MK2 A;  1ELZ A;  2W8D A;  4LRF A;  1ELX A;  3E2D A;  3M8W A;  3B5Q A;  5GOV A;  4ZG6 A;  1P49 A;  4GTZ A;  4LRE A;  4NWX A; 
#chains in the Genus database with same CATH homology
 1E33 P;  3NKO A;  1E2S P;  2ZKT A;  3BDF A;  4KJD A;  2RH6 A;  1N2L A;  4YR1 A;  4UPH A;  3T02 A;  4LRB A;  4GTX A;  3KD8 A;  1KH4 A;  4MIV A;  4UOR A;  5LIA A;  3UN2 A;  1KH5 A;  5LQQ A;  3MK0 A;  3M8Y A;  4CXU A;  4KM4 A;  1ALK A;  2W5S A;  1B8J A;  2GSN A;  4MY4 A;  4LR7 A;  1ED8 A;  1AJD A;  3TWZ A;  5L0B A;  3BDG A;  3WAW A;  4FDI A;  3NKM A;  4LRC A;  1EW8 A;  4UOP A;  1ZEF A;  3WBH A;  3SZY A;  4FDJ A;  1ANI A;  3DYC A;  5INH A;  4UPL A;  3T01 A;  4LR8 A;  1O98 A;  3BDG B;  2XR9 A;  3NKP A;  5DLV A;  4LRA A;  2GA3 A;  4KJG A;  4CYS A;  4B56 A;  5TJ3 A;  4ZG9 A;  1ZEB A;  3M7V A;  3TX0 A;  4N7T A;  4KAV A;  2GLQ A;  5HRT A;  3M8Z A;  1Y7A A;  3ED4 A;  3DPC A;  4ZG7 A;  4LR2 A;  2IFY A;  5K4P A;  1URB A;  3CMR A;  1EI6 A;  1URA A;  4NWJ A;  5KXA A;  3UNY A;  4LR9 A;  2W8S A;  5L0K A;  3NKR A;  4TN0 A;  3UN5 A;  5EGH A;  5GRR A;  2W5X A;  3WAX A;  2GSU A;  2QZU A;  3WAV A;  1ANJ A;  5IJQ A;  1ELY A;  2IUC A;  4LQY A;  2W5W A;  1SHQ A;  1ALI A;  5L0E A;  2W5V A;  4QAX A;  4CXK A;  3IDD A;  2W5T A;  2IUC B;  1HQA A;  1ALH A;  1AUK A;  4KAY A;  4LRD A;  5DLT A;  1ED9 A;  1N2K A;  2XRG A;  2W5Q A;  4CXS A;  3T00 A;  1Y6V A;  1SHN A;  3IGY B;  3OT9 A;  3NKN A;  2GSO A;  4GTW A;  4UPI A;  2VQR A;  3NKQ A;  1KHL A;  4UPK A;  5AJ9 A;  1ALJ A;  5DLW A;  1KH9 A;  2D1G A;  1E1Z P;  3UO0 A;  3MK1 A;  3A52 A;  2X98 A;  1KH7 A;  1EJJ A;  1FSU A;  3WAY A;  3SZZ A;  4UOO A;  3IGZ B;  4CYR A;  3TG0 A;  1KHK A;  1O99 A;  1KHJ A;  1EW9 A;  4MHX A;  1K7H A;  1E3C P;  4ZGA A;  1HJK A;  3NVL A;  1KHN A;  5EGE A;  3BDH A;  2W5R A;  4GTY A;  3LXQ A;  1EQJ A;  3UN3 A;  1AJC A;  1ZED A;  5LRN A;  5LRM A;  1EW2 A;  1HDH A;  5IJS A;  1AJA A;  5C66 A;  3Q3Q A;  1AJB A;  2G9Y A;  2ANH A;  3MK2 A;  1ELZ A;  2W8D A;  4LRF A;  1ELX A;  3E2D A;  3M8W A;  3B5Q A;  5GOV A;  4ZG6 A;  1P49 A;  4GTZ A;  4LRE A;  4NWX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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