1ALKA

Reaction mechanism of alkaline phosphatase based on crystal structures. two metal ion catalysis
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
Knots found
sequence length
449
structure length
449
Chain Sequence
TPEMPVLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Alkaline phosphatase
source organism Escherichia coli
publication title Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
total genus 158
structure length 449
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1993-03-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1alkA00
2W5SA 3BDHA 5INHA 4MHXA 3TX0A 4UORA 1URBA 4LREA 5L0EA 1EQJA 5LRMA 1EJJA 2X98A 1AJCA 3TWZA 5LQQA 2G9YA 1KHKA 2D1GA 4LRBA 1Y6VA 2ZKTA 3MK1A 2GA3A 2W5RA 1EI6A 1O99A 4GTZA 4CXSA 3SZZA 3IGYB 4GTXA 3MK0A 4CXKA 4ZG7A 2W8DA 3NVLA 3NKPA 3BDGB 2IUCA 3A52A 4NWJA 4CYRA 3TG0A 4NWXA 5EGHA 3T00A 3NKMA 1O98A 5L0BA 1B8JA 1K7HA 5GOVA 2GSOA 3UN5A 1AJAA 3M8WA 2XRGA 1ELZA 3WAWA 4UPLA 3NKRA 4UPKA 1URAA 2W5QA 4LRAA 1HJKA 1N2LA 3NKNA 3BDGA 3M8YA 1EW8A 4MIVA 1AUKA 3NKOA 5L0KA 2VQRA 2W5WA 3KD8A 3WAYA 1N2KA 1ANIA 1EW2A 4LRCA 4CYSA 3CMRA 4ZGAA 1SHNA 3MK2A 5HRTA 5K4PA 4ZG9A 3LXQA 2W5VA 1ZEDA 5EGEA 1KHLA 1ALKA 3IDDA 1ED9A 4KJDA 5IJSA 1ALIA 4LQYA 5LRNA 1ELXA 5LIAA 4MY4A 3UNYA 3Q3QA 2GSNA 3DPCA 4B56A 1Y7AA 1HDHA 3WBHA 4GTWA 4KAYA 1ELYA 1KHNA 1FSUA 2GLQA 3NKQA 4UPIA 4GTYA 3UN2A 3WAXA 2ANHA 4YR1A 4UPHA 3T02A 5TJ3A 4UOOA 3SZYA 3UO0A 1E33P 4LR2A 4LR8A 5GRRA 2IFYA 2W5XA 4LR9A 3B5QA 4CXUA 1E1ZP 2W5TA 5DLVA 5IJQA 3ED4A 1KHJA 4LRDA 5C66A 1SHQA 3M8ZA 2XR9A 3M7VA 4KJGA 1ANJA 2IUCB 5DLTA 3T01A 4QAXA 5KXAA 1ALJA 1HQAA 1KH4A 3BDFA 2GSUA 1ALHA 3WAVA 1AJBA 1ED8A 4LR7A 1EW9A 4ZG6A 1AJDA 3DYCA 4UOPA 2W8SA 3OT9A 1ZEBA 4N7TA 4KAVA 5DLWA 4KM4A 1KH5A 4LRFA 2QZUA 3IGZB 1KH9A 4TN0A 1E2SP 1P49A 4FDJA 1ZEFA 3E2DA 1E3CP 3UN3A 4FDIA 1KH7A 2RH6A 5AJ9A
chains in the Genus database with same CATH superfamily
2W5SA 3BDHA 5INHA 4MHXA 3TX0A 4UORA 1URBA 4LREA 5L0EA 1EQJA 5LRMA 1EJJA 2X98A 1AJCA 3TWZA 5LQQA 2G9YA 1KHKA 2D1GA 4LRBA 1Y6VA 2ZKTA 3MK1A 2GA3A 2W5RA 1EI6A 1O99A 4GTZA 4CXSA 3SZZA 3IGYB 4GTXA 3MK0A 4CXKA 4ZG7A 2W8DA 3NVLA 3NKPA 3BDGB 2IUCA 3A52A 4NWJA 4CYRA 3TG0A 4NWXA 5EGHA 3T00A 3NKMA 1O98A 5L0BA 1B8JA 1K7HA 5GOVA 2GSOA 3UN5A 1AJAA 3M8WA 2XRGA 1ELZA 3WAWA 4UPLA 3NKRA 4UPKA 1URAA 2W5QA 4LRAA 1HJKA 1N2LA 3NKNA 3BDGA 3M8YA 1EW8A 4MIVA 1AUKA 3NKOA 5L0KA 2VQRA 2W5WA 3KD8A 3WAYA 1N2KA 1ANIA 1EW2A 4LRCA 4CYSA 3CMRA 4ZGAA 1SHNA 3MK2A 5HRTA 5K4PA 4ZG9A 3LXQA 2W5VA 1ZEDA 5EGEA 1KHLA 1ALKA 3IDDA 1ED9A 4KJDA 5IJSA 1ALIA 4LQYA 5LRNA 1ELXA 5LIAA 4MY4A 3UNYA 3Q3QA 2GSNA 3DPCA 4B56A 1Y7AA 1HDHA 3WBHA 4GTWA 4KAYA 1ELYA 1KHNA 1FSUA 2GLQA 3NKQA 4UPIA 4GTYA 3UN2A 3WAXA 2ANHA 4YR1A 4UPHA 3T02A 5TJ3A 4UOOA 3SZYA 3UO0A 1E33P 4LR2A 4LR8A 5GRRA 2IFYA 2W5XA 4LR9A 3B5QA 4CXUA 1E1ZP 2W5TA 5DLVA 5IJQA 3ED4A 1KHJA 4LRDA 5C66A 1SHQA 3M8ZA 2XR9A 3M7VA 4KJGA 1ANJA 2IUCB 5DLTA 3T01A 4QAXA 5KXAA 1ALJA 1HQAA 1KH4A 3BDFA 2GSUA 1ALHA 3WAVA 1AJBA 1ED8A 4LR7A 1EW9A 4ZG6A 1AJDA 3DYCA 4UOPA 2W8SA 3OT9A 1ZEBA 4N7TA 4KAVA 5DLWA 4KM4A 1KH5A 4LRFA 2QZUA 3IGZB 1KH9A 4TN0A 1E2SP 1P49A 4FDJA 1ZEFA 3E2DA 1E3CP 3UN3A 4FDIA 1KH7A 2RH6A 5AJ9A
chains in the Genus database with same CATH topology
2W5SA 3BDHA 5INHA 4MHXA 3TX0A 4UORA 1URBA 4LREA 5L0EA 1EQJA 5LRMA 1EJJA 2X98A 1AJCA 3TWZA 5LQQA 2G9YA 1KHKA 2D1GA 4LRBA 1Y6VA 2ZKTA 3MK1A 2GA3A 2W5RA 1EI6A 1O99A 4GTZA 4CXSA 3SZZA 3IGYB 4GTXA 3MK0A 4CXKA 4ZG7A 2W8DA 3NVLA 3NKPA 3BDGB 2IUCA 3A52A 4NWJA 4CYRA 3TG0A 4NWXA 5EGHA 3T00A 3NKMA 1O98A 5L0BA 1B8JA 1K7HA 5GOVA 2GSOA 3UN5A 1AJAA 3M8WA 2XRGA 1ELZA 3WAWA 4UPLA 3NKRA 4UPKA 1URAA 2W5QA 4LRAA 1HJKA 1N2LA 3NKNA 3BDGA 3M8YA 1EW8A 4MIVA 1AUKA 3NKOA 5L0KA 2VQRA 2W5WA 3KD8A 3WAYA 1N2KA 1ANIA 1EW2A 4LRCA 4CYSA 3CMRA 4ZGAA 1SHNA 3MK2A 5HRTA 5K4PA 4ZG9A 3LXQA 2W5VA 1ZEDA 5EGEA 1KHLA 1ALKA 3IDDA 1ED9A 4KJDA 5IJSA 1ALIA 4LQYA 5LRNA 1ELXA 5LIAA 4MY4A 3UNYA 3Q3QA 2GSNA 3DPCA 4B56A 1Y7AA 1HDHA 3WBHA 4GTWA 4KAYA 1ELYA 1KHNA 1FSUA 2GLQA 3NKQA 4UPIA 4GTYA 3UN2A 3WAXA 2ANHA 4YR1A 4UPHA 3T02A 5TJ3A 4UOOA 3SZYA 3UO0A 1E33P 4LR2A 4LR8A 5GRRA 2IFYA 2W5XA 4LR9A 3B5QA 4CXUA 1E1ZP 2W5TA 5DLVA 5IJQA 3ED4A 1KHJA 4LRDA 5C66A 1SHQA 3M8ZA 2XR9A 3M7VA 4KJGA 1ANJA 2IUCB 5DLTA 3T01A 4QAXA 5KXAA 1ALJA 1HQAA 1KH4A 3BDFA 2GSUA 1ALHA 3WAVA 1AJBA 1ED8A 4LR7A 1EW9A 4ZG6A 1AJDA 3DYCA 4UOPA 2W8SA 3OT9A 1ZEBA 4N7TA 4KAVA 5DLWA 4KM4A 1KH5A 4LRFA 2QZUA 3IGZB 1KH9A 4TN0A 1E2SP 1P49A 4FDJA 1ZEFA 3E2DA 1E3CP 3UN3A 4FDIA 1KH7A 2RH6A 5AJ9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W5S A;  3BDH A;  5INH A;  4MHX A;  3TX0 A;  4UOR A;  1URB A;  4LRE A;  5L0E A;  1EQJ A;  5LRM A;  1EJJ A;  2X98 A;  1AJC A;  3TWZ A;  5LQQ A;  2G9Y A;  1KHK A;  2D1G A;  4LRB A;  1Y6V A;  2ZKT A;  3MK1 A;  2GA3 A;  2W5R A;  1EI6 A;  1O99 A;  4GTZ A;  4CXS A;  3SZZ A;  3IGY B;  4GTX A;  3MK0 A;  4CXK A;  4ZG7 A;  2W8D A;  3NVL A;  3NKP A;  3BDG B;  2IUC A;  3A52 A;  4NWJ A;  4CYR A;  3TG0 A;  4NWX A;  5EGH A;  3T00 A;  3NKM A;  1O98 A;  5L0B A;  1B8J A;  1K7H A;  5GOV A;  2GSO A;  3UN5 A;  1AJA A;  3M8W A;  2XRG A;  1ELZ A;  3WAW A;  4UPL A;  3NKR A;  4UPK A;  1URA A;  2W5Q A;  4LRA A;  1HJK A;  1N2L A;  3NKN A;  3BDG A;  3M8Y A;  1EW8 A;  4MIV A;  1AUK A;  3NKO A;  5L0K A;  2VQR A;  2W5W A;  3KD8 A;  3WAY A;  1N2K A;  1ANI A;  1EW2 A;  4LRC A;  4CYS A;  3CMR A;  4ZGA A;  1SHN A;  3MK2 A;  5HRT A;  5K4P A;  4ZG9 A;  3LXQ A;  2W5V A;  1ZED A;  5EGE A;  1KHL A;  1ALK A;  3IDD A;  1ED9 A;  4KJD A;  5IJS A;  1ALI A;  4LQY A;  5LRN A;  1ELX A;  5LIA A;  4MY4 A;  3UNY A;  3Q3Q A;  2GSN A;  3DPC A;  4B56 A;  1Y7A A;  1HDH A;  3WBH A;  4GTW A;  4KAY A;  1ELY A;  1KHN A;  1FSU A;  2GLQ A;  3NKQ A;  4UPI A;  4GTY A;  3UN2 A;  3WAX A;  2ANH A;  4YR1 A;  4UPH A;  3T02 A;  5TJ3 A;  4UOO A;  3SZY A;  3UO0 A;  1E33 P;  4LR2 A;  4LR8 A;  5GRR A;  2IFY A;  2W5X A;  4LR9 A;  3B5Q A;  4CXU A;  1E1Z P;  2W5T A;  5DLV A;  5IJQ A;  3ED4 A;  1KHJ A;  4LRD A;  5C66 A;  1SHQ A;  3M8Z A;  2XR9 A;  3M7V A;  4KJG A;  1ANJ A;  2IUC B;  5DLT A;  3T01 A;  4QAX A;  5KXA A;  1ALJ A;  1HQA A;  1KH4 A;  3BDF A;  2GSU A;  1ALH A;  3WAV A;  1AJB A;  1ED8 A;  4LR7 A;  1EW9 A;  4ZG6 A;  1AJD A;  3DYC A;  4UOP A;  2W8S A;  3OT9 A;  1ZEB A;  4N7T A;  4KAV A;  5DLW A;  4KM4 A;  1KH5 A;  4LRF A;  2QZU A;  3IGZ B;  1KH9 A;  4TN0 A;  1E2S P;  1P49 A;  4FDJ A;  1ZEF A;  3E2D A;  1E3C P;  3UN3 A;  4FDI A;  1KH7 A;  2RH6 A;  5AJ9 A; 
#chains in the Genus database with same CATH topology
 2W5S A;  3BDH A;  5INH A;  4MHX A;  3TX0 A;  4UOR A;  1URB A;  4LRE A;  5L0E A;  1EQJ A;  5LRM A;  1EJJ A;  2X98 A;  1AJC A;  3TWZ A;  5LQQ A;  2G9Y A;  1KHK A;  2D1G A;  4LRB A;  1Y6V A;  2ZKT A;  3MK1 A;  2GA3 A;  2W5R A;  1EI6 A;  1O99 A;  4GTZ A;  4CXS A;  3SZZ A;  3IGY B;  4GTX A;  3MK0 A;  4CXK A;  4ZG7 A;  2W8D A;  3NVL A;  3NKP A;  3BDG B;  2IUC A;  3A52 A;  4NWJ A;  4CYR A;  3TG0 A;  4NWX A;  5EGH A;  3T00 A;  3NKM A;  1O98 A;  5L0B A;  1B8J A;  1K7H A;  5GOV A;  2GSO A;  3UN5 A;  1AJA A;  3M8W A;  2XRG A;  1ELZ A;  3WAW A;  4UPL A;  3NKR A;  4UPK A;  1URA A;  2W5Q A;  4LRA A;  1HJK A;  1N2L A;  3NKN A;  3BDG A;  3M8Y A;  1EW8 A;  4MIV A;  1AUK A;  3NKO A;  5L0K A;  2VQR A;  2W5W A;  3KD8 A;  3WAY A;  1N2K A;  1ANI A;  1EW2 A;  4LRC A;  4CYS A;  3CMR A;  4ZGA A;  1SHN A;  3MK2 A;  5HRT A;  5K4P A;  4ZG9 A;  3LXQ A;  2W5V A;  1ZED A;  5EGE A;  1KHL A;  1ALK A;  3IDD A;  1ED9 A;  4KJD A;  5IJS A;  1ALI A;  4LQY A;  5LRN A;  1ELX A;  5LIA A;  4MY4 A;  3UNY A;  3Q3Q A;  2GSN A;  3DPC A;  4B56 A;  1Y7A A;  1HDH A;  3WBH A;  4GTW A;  4KAY A;  1ELY A;  1KHN A;  1FSU A;  2GLQ A;  3NKQ A;  4UPI A;  4GTY A;  3UN2 A;  3WAX A;  2ANH A;  4YR1 A;  4UPH A;  3T02 A;  5TJ3 A;  4UOO A;  3SZY A;  3UO0 A;  1E33 P;  4LR2 A;  4LR8 A;  5GRR A;  2IFY A;  2W5X A;  4LR9 A;  3B5Q A;  4CXU A;  1E1Z P;  2W5T A;  5DLV A;  5IJQ A;  3ED4 A;  1KHJ A;  4LRD A;  5C66 A;  1SHQ A;  3M8Z A;  2XR9 A;  3M7V A;  4KJG A;  1ANJ A;  2IUC B;  5DLT A;  3T01 A;  4QAX A;  5KXA A;  1ALJ A;  1HQA A;  1KH4 A;  3BDF A;  2GSU A;  1ALH A;  3WAV A;  1AJB A;  1ED8 A;  4LR7 A;  1EW9 A;  4ZG6 A;  1AJD A;  3DYC A;  4UOP A;  2W8S A;  3OT9 A;  1ZEB A;  4N7T A;  4KAV A;  5DLW A;  4KM4 A;  1KH5 A;  4LRF A;  2QZU A;  3IGZ B;  1KH9 A;  4TN0 A;  1E2S P;  1P49 A;  4FDJ A;  1ZEF A;  3E2D A;  1E3C P;  3UN3 A;  4FDI A;  1KH7 A;  2RH6 A;  5AJ9 A; 
#chains in the Genus database with same CATH homology
 2W5S A;  3BDH A;  5INH A;  4MHX A;  3TX0 A;  4UOR A;  1URB A;  4LRE A;  5L0E A;  1EQJ A;  5LRM A;  1EJJ A;  2X98 A;  1AJC A;  3TWZ A;  5LQQ A;  2G9Y A;  1KHK A;  2D1G A;  4LRB A;  1Y6V A;  2ZKT A;  3MK1 A;  2GA3 A;  2W5R A;  1EI6 A;  1O99 A;  4GTZ A;  4CXS A;  3SZZ A;  3IGY B;  4GTX A;  3MK0 A;  4CXK A;  4ZG7 A;  2W8D A;  3NVL A;  3NKP A;  3BDG B;  2IUC A;  3A52 A;  4NWJ A;  4CYR A;  3TG0 A;  4NWX A;  5EGH A;  3T00 A;  3NKM A;  1O98 A;  5L0B A;  1B8J A;  1K7H A;  5GOV A;  2GSO A;  3UN5 A;  1AJA A;  3M8W A;  2XRG A;  1ELZ A;  3WAW A;  4UPL A;  3NKR A;  4UPK A;  1URA A;  2W5Q A;  4LRA A;  1HJK A;  1N2L A;  3NKN A;  3BDG A;  3M8Y A;  1EW8 A;  4MIV A;  1AUK A;  3NKO A;  5L0K A;  2VQR A;  2W5W A;  3KD8 A;  3WAY A;  1N2K A;  1ANI A;  1EW2 A;  4LRC A;  4CYS A;  3CMR A;  4ZGA A;  1SHN A;  3MK2 A;  5HRT A;  5K4P A;  4ZG9 A;  3LXQ A;  2W5V A;  1ZED A;  5EGE A;  1KHL A;  1ALK A;  3IDD A;  1ED9 A;  4KJD A;  5IJS A;  1ALI A;  4LQY A;  5LRN A;  1ELX A;  5LIA A;  4MY4 A;  3UNY A;  3Q3Q A;  2GSN A;  3DPC A;  4B56 A;  1Y7A A;  1HDH A;  3WBH A;  4GTW A;  4KAY A;  1ELY A;  1KHN A;  1FSU A;  2GLQ A;  3NKQ A;  4UPI A;  4GTY A;  3UN2 A;  3WAX A;  2ANH A;  4YR1 A;  4UPH A;  3T02 A;  5TJ3 A;  4UOO A;  3SZY A;  3UO0 A;  1E33 P;  4LR2 A;  4LR8 A;  5GRR A;  2IFY A;  2W5X A;  4LR9 A;  3B5Q A;  4CXU A;  1E1Z P;  2W5T A;  5DLV A;  5IJQ A;  3ED4 A;  1KHJ A;  4LRD A;  5C66 A;  1SHQ A;  3M8Z A;  2XR9 A;  3M7V A;  4KJG A;  1ANJ A;  2IUC B;  5DLT A;  3T01 A;  4QAX A;  5KXA A;  1ALJ A;  1HQA A;  1KH4 A;  3BDF A;  2GSU A;  1ALH A;  3WAV A;  1AJB A;  1ED8 A;  4LR7 A;  1EW9 A;  4ZG6 A;  1AJD A;  3DYC A;  4UOP A;  2W8S A;  3OT9 A;  1ZEB A;  4N7T A;  4KAV A;  5DLW A;  4KM4 A;  1KH5 A;  4LRF A;  2QZU A;  3IGZ B;  1KH9 A;  4TN0 A;  1E2S P;  1P49 A;  4FDJ A;  1ZEF A;  3E2D A;  1E3C P;  3UN3 A;  4FDI A;  1KH7 A;  2RH6 A;  5AJ9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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