1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Non specific mono-esterase
source organism Escherichia coli
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
5DLWA 3B5QA 2W5VA 4MIVA 2IUCB 3WAWA 1KHJA 3NKPA 5GOVA 1ANJA 5EGEA 1N2LA 5L0EA 1ANIA 2GA3A 5IJQA 4KJDA 1EQJA 1ZEBA 1ALIA 2GSNA 4NWXA 5DLTA 3M8ZA 3WAXA 4CXKA 1EI6A 3MK0A 1ELZA 1AJCA 1K7HA 1ED8A 4ZG7A 5L0BA 3WAYA 3BDFA 2ANHA 4UOOA 1Y7AA 1EW2A 3BDGB 2W5WA 4GTWA 4ZG6A 4KM4A 3LXQA 1ELYA 5LRNA 4CXUA 4MHXA 3DYCA 2IFYA 3M8WA 3UN5A 1AUKA 3MK2A 3DPCA 5GRRA 5KXAA 1KH4A 1E1ZP 4LRDA 2W5SA 1KHKA 1EW8A 4KJGA 3T02A 1ALJA 4QAXA 1HDHA 1Y6VA 2W8SA 1N2KA 3IDDA 4LR2A 3OT9A 2XRGA 1HQAA 2W8DA 3IGYB 4LRAA 3UN2A 1KHLA 4TN0A 3CMRA 4ZG9A 4LR9A 3NVLA 2XR9A 2W5TA 3NKOA 4GTXA 3TWZA 3WBHA 3ED4A 4KAYA 4UOPA 3IGZB 4ZGAA 2X98A 4LQYA 4LR8A 5IJSA 3Q3QA 5DLVA 3NKMA 5C66A 5INHA 5LQQA 1KHNA 4GTYA 3E2DA 2D1GA 4UPLA 2VQRA 1URBA 5LRMA 1E33P 4LRFA 3MK1A 4UPHA 1URAA 4FDJA 4CYRA 3TX0A 4UPKA 2GLQA 4LREA 4MY4A 5EGHA 3M7VA 1ELXA 4UPIA 1SHNA 3M8YA 3NKNA 5K4PA 1ALKA 5TJ3A 1AJBA 1E2SP 1B8JA 2W5QA 2W5RA 4B56A 5L0KA 4N7TA 3SZYA 1ED9A 4LRBA 2IUCA 2RH6A 4LRCA 4FDIA 3NKQA 3NKRA 3TG0A 3T01A 4KAVA 5AJ9A 3T00A 3UN3A 4CYSA 3SZZA 2GSUA 1P49A 2QZUA 1KH5A 1ZEFA 3WAVA 1SHQA 4LR7A 1HJKA 4CXSA 1E3CP 4YR1A 1O99A 3BDHA 3UNYA 2ZKTA 1KH7A 2G9YA 1AJAA 2W5XA 3UO0A 1FSUA 2GSOA 3KD8A 4GTZA 4NWJA 1EW9A 5HRTA 3BDGA 4UORA 5LIAA 3A52A 1EJJA 1ZEDA 1KH9A 1O98A 1ALHA 1AJDA
chains in the Genus database with same CATH superfamily
5DLWA 3B5QA 2W5VA 4MIVA 2IUCB 3WAWA 1KHJA 3NKPA 5GOVA 1ANJA 5EGEA 1N2LA 5L0EA 1ANIA 2GA3A 5IJQA 4KJDA 1EQJA 1ZEBA 1ALIA 2GSNA 4NWXA 5DLTA 3M8ZA 3WAXA 4CXKA 1EI6A 3MK0A 1ELZA 1AJCA 1K7HA 1ED8A 4ZG7A 5L0BA 3WAYA 3BDFA 2ANHA 4UOOA 1Y7AA 1EW2A 3BDGB 2W5WA 4GTWA 4ZG6A 4KM4A 3LXQA 1ELYA 5LRNA 4CXUA 4MHXA 3DYCA 2IFYA 3M8WA 3UN5A 1AUKA 3MK2A 3DPCA 5GRRA 5KXAA 1KH4A 1E1ZP 4LRDA 2W5SA 1KHKA 1EW8A 4KJGA 3T02A 1ALJA 4QAXA 1HDHA 1Y6VA 2W8SA 1N2KA 3IDDA 4LR2A 3OT9A 2XRGA 1HQAA 2W8DA 3IGYB 4LRAA 3UN2A 1KHLA 4TN0A 3CMRA 4ZG9A 4LR9A 3NVLA 2XR9A 2W5TA 3NKOA 4GTXA 3TWZA 3WBHA 3ED4A 4KAYA 4UOPA 3IGZB 4ZGAA 2X98A 4LQYA 4LR8A 5IJSA 3Q3QA 5DLVA 3NKMA 5C66A 5INHA 5LQQA 1KHNA 4GTYA 3E2DA 2D1GA 4UPLA 2VQRA 1URBA 5LRMA 1E33P 4LRFA 3MK1A 4UPHA 1URAA 4FDJA 4CYRA 3TX0A 4UPKA 2GLQA 4LREA 4MY4A 5EGHA 3M7VA 1ELXA 4UPIA 1SHNA 3M8YA 3NKNA 5K4PA 1ALKA 5TJ3A 1AJBA 1E2SP 1B8JA 2W5QA 2W5RA 4B56A 5L0KA 4N7TA 3SZYA 1ED9A 4LRBA 2IUCA 2RH6A 4LRCA 4FDIA 3NKQA 3NKRA 3TG0A 3T01A 4KAVA 5AJ9A 3T00A 3UN3A 4CYSA 3SZZA 2GSUA 1P49A 2QZUA 1KH5A 1ZEFA 3WAVA 1SHQA 4LR7A 1HJKA 4CXSA 1E3CP 4YR1A 1O99A 3BDHA 3UNYA 2ZKTA 1KH7A 2G9YA 1AJAA 2W5XA 3UO0A 1FSUA 2GSOA 3KD8A 4GTZA 4NWJA 1EW9A 5HRTA 3BDGA 4UORA 5LIAA 3A52A 1EJJA 1ZEDA 1KH9A 1O98A 1ALHA 1AJDA
chains in the Genus database with same CATH topology
5DLWA 3B5QA 2W5VA 4MIVA 2IUCB 3WAWA 1KHJA 3NKPA 5GOVA 1ANJA 5EGEA 1N2LA 5L0EA 1ANIA 2GA3A 5IJQA 4KJDA 1EQJA 1ZEBA 1ALIA 2GSNA 4NWXA 5DLTA 3M8ZA 3WAXA 4CXKA 1EI6A 3MK0A 1ELZA 1AJCA 1K7HA 1ED8A 4ZG7A 5L0BA 3WAYA 3BDFA 2ANHA 4UOOA 1Y7AA 1EW2A 3BDGB 2W5WA 4GTWA 4ZG6A 4KM4A 3LXQA 1ELYA 5LRNA 4CXUA 4MHXA 3DYCA 2IFYA 3M8WA 3UN5A 1AUKA 3MK2A 3DPCA 5GRRA 5KXAA 1KH4A 1E1ZP 4LRDA 2W5SA 1KHKA 1EW8A 4KJGA 3T02A 1ALJA 4QAXA 1HDHA 1Y6VA 2W8SA 1N2KA 3IDDA 4LR2A 3OT9A 2XRGA 1HQAA 2W8DA 3IGYB 4LRAA 3UN2A 1KHLA 4TN0A 3CMRA 4ZG9A 4LR9A 3NVLA 2XR9A 2W5TA 3NKOA 4GTXA 3TWZA 3WBHA 3ED4A 4KAYA 4UOPA 3IGZB 4ZGAA 2X98A 4LQYA 4LR8A 5IJSA 3Q3QA 5DLVA 3NKMA 5C66A 5INHA 5LQQA 1KHNA 4GTYA 3E2DA 2D1GA 4UPLA 2VQRA 1URBA 5LRMA 1E33P 4LRFA 3MK1A 4UPHA 1URAA 4FDJA 4CYRA 3TX0A 4UPKA 2GLQA 4LREA 4MY4A 5EGHA 3M7VA 1ELXA 4UPIA 1SHNA 3M8YA 3NKNA 5K4PA 1ALKA 5TJ3A 1AJBA 1E2SP 1B8JA 2W5QA 2W5RA 4B56A 5L0KA 4N7TA 3SZYA 1ED9A 4LRBA 2IUCA 2RH6A 4LRCA 4FDIA 3NKQA 3NKRA 3TG0A 3T01A 4KAVA 5AJ9A 3T00A 3UN3A 4CYSA 3SZZA 2GSUA 1P49A 2QZUA 1KH5A 1ZEFA 3WAVA 1SHQA 4LR7A 1HJKA 4CXSA 1E3CP 4YR1A 1O99A 3BDHA 3UNYA 2ZKTA 1KH7A 2G9YA 1AJAA 2W5XA 3UO0A 1FSUA 2GSOA 3KD8A 4GTZA 4NWJA 1EW9A 5HRTA 3BDGA 4UORA 5LIAA 3A52A 1EJJA 1ZEDA 1KH9A 1O98A 1ALHA 1AJDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DLW A;  3B5Q A;  2W5V A;  4MIV A;  2IUC B;  3WAW A;  1KHJ A;  3NKP A;  5GOV A;  1ANJ A;  5EGE A;  1N2L A;  5L0E A;  1ANI A;  2GA3 A;  5IJQ A;  4KJD A;  1EQJ A;  1ZEB A;  1ALI A;  2GSN A;  4NWX A;  5DLT A;  3M8Z A;  3WAX A;  4CXK A;  1EI6 A;  3MK0 A;  1ELZ A;  1AJC A;  1K7H A;  1ED8 A;  4ZG7 A;  5L0B A;  3WAY A;  3BDF A;  2ANH A;  4UOO A;  1Y7A A;  1EW2 A;  3BDG B;  2W5W A;  4GTW A;  4ZG6 A;  4KM4 A;  3LXQ A;  1ELY A;  5LRN A;  4CXU A;  4MHX A;  3DYC A;  2IFY A;  3M8W A;  3UN5 A;  1AUK A;  3MK2 A;  3DPC A;  5GRR A;  5KXA A;  1KH4 A;  1E1Z P;  4LRD A;  2W5S A;  1KHK A;  1EW8 A;  4KJG A;  3T02 A;  1ALJ A;  4QAX A;  1HDH A;  1Y6V A;  2W8S A;  1N2K A;  3IDD A;  4LR2 A;  3OT9 A;  2XRG A;  1HQA A;  2W8D A;  3IGY B;  4LRA A;  3UN2 A;  1KHL A;  4TN0 A;  3CMR A;  4ZG9 A;  4LR9 A;  3NVL A;  2XR9 A;  2W5T A;  3NKO A;  4GTX A;  3TWZ A;  3WBH A;  3ED4 A;  4KAY A;  4UOP A;  3IGZ B;  4ZGA A;  2X98 A;  4LQY A;  4LR8 A;  5IJS A;  3Q3Q A;  5DLV A;  3NKM A;  5C66 A;  5INH A;  5LQQ A;  1KHN A;  4GTY A;  3E2D A;  2D1G A;  4UPL A;  2VQR A;  1URB A;  5LRM A;  1E33 P;  4LRF A;  3MK1 A;  4UPH A;  1URA A;  4FDJ A;  4CYR A;  3TX0 A;  4UPK A;  2GLQ A;  4LRE A;  4MY4 A;  5EGH A;  3M7V A;  1ELX A;  4UPI A;  1SHN A;  3M8Y A;  3NKN A;  5K4P A;  1ALK A;  5TJ3 A;  1AJB A;  1E2S P;  1B8J A;  2W5Q A;  2W5R A;  4B56 A;  5L0K A;  4N7T A;  3SZY A;  1ED9 A;  4LRB A;  2IUC A;  2RH6 A;  4LRC A;  4FDI A;  3NKQ A;  3NKR A;  3TG0 A;  3T01 A;  4KAV A;  5AJ9 A;  3T00 A;  3UN3 A;  4CYS A;  3SZZ A;  2GSU A;  1P49 A;  2QZU A;  1KH5 A;  1ZEF A;  3WAV A;  1SHQ A;  4LR7 A;  1HJK A;  4CXS A;  1E3C P;  4YR1 A;  1O99 A;  3BDH A;  3UNY A;  2ZKT A;  1KH7 A;  2G9Y A;  1AJA A;  2W5X A;  3UO0 A;  1FSU A;  2GSO A;  3KD8 A;  4GTZ A;  4NWJ A;  1EW9 A;  5HRT A;  3BDG A;  4UOR A;  5LIA A;  3A52 A;  1EJJ A;  1ZED A;  1KH9 A;  1O98 A;  1ALH A;  1AJD A; 
#chains in the Genus database with same CATH topology
 5DLW A;  3B5Q A;  2W5V A;  4MIV A;  2IUC B;  3WAW A;  1KHJ A;  3NKP A;  5GOV A;  1ANJ A;  5EGE A;  1N2L A;  5L0E A;  1ANI A;  2GA3 A;  5IJQ A;  4KJD A;  1EQJ A;  1ZEB A;  1ALI A;  2GSN A;  4NWX A;  5DLT A;  3M8Z A;  3WAX A;  4CXK A;  1EI6 A;  3MK0 A;  1ELZ A;  1AJC A;  1K7H A;  1ED8 A;  4ZG7 A;  5L0B A;  3WAY A;  3BDF A;  2ANH A;  4UOO A;  1Y7A A;  1EW2 A;  3BDG B;  2W5W A;  4GTW A;  4ZG6 A;  4KM4 A;  3LXQ A;  1ELY A;  5LRN A;  4CXU A;  4MHX A;  3DYC A;  2IFY A;  3M8W A;  3UN5 A;  1AUK A;  3MK2 A;  3DPC A;  5GRR A;  5KXA A;  1KH4 A;  1E1Z P;  4LRD A;  2W5S A;  1KHK A;  1EW8 A;  4KJG A;  3T02 A;  1ALJ A;  4QAX A;  1HDH A;  1Y6V A;  2W8S A;  1N2K A;  3IDD A;  4LR2 A;  3OT9 A;  2XRG A;  1HQA A;  2W8D A;  3IGY B;  4LRA A;  3UN2 A;  1KHL A;  4TN0 A;  3CMR A;  4ZG9 A;  4LR9 A;  3NVL A;  2XR9 A;  2W5T A;  3NKO A;  4GTX A;  3TWZ A;  3WBH A;  3ED4 A;  4KAY A;  4UOP A;  3IGZ B;  4ZGA A;  2X98 A;  4LQY A;  4LR8 A;  5IJS A;  3Q3Q A;  5DLV A;  3NKM A;  5C66 A;  5INH A;  5LQQ A;  1KHN A;  4GTY A;  3E2D A;  2D1G A;  4UPL A;  2VQR A;  1URB A;  5LRM A;  1E33 P;  4LRF A;  3MK1 A;  4UPH A;  1URA A;  4FDJ A;  4CYR A;  3TX0 A;  4UPK A;  2GLQ A;  4LRE A;  4MY4 A;  5EGH A;  3M7V A;  1ELX A;  4UPI A;  1SHN A;  3M8Y A;  3NKN A;  5K4P A;  1ALK A;  5TJ3 A;  1AJB A;  1E2S P;  1B8J A;  2W5Q A;  2W5R A;  4B56 A;  5L0K A;  4N7T A;  3SZY A;  1ED9 A;  4LRB A;  2IUC A;  2RH6 A;  4LRC A;  4FDI A;  3NKQ A;  3NKR A;  3TG0 A;  3T01 A;  4KAV A;  5AJ9 A;  3T00 A;  3UN3 A;  4CYS A;  3SZZ A;  2GSU A;  1P49 A;  2QZU A;  1KH5 A;  1ZEF A;  3WAV A;  1SHQ A;  4LR7 A;  1HJK A;  4CXS A;  1E3C P;  4YR1 A;  1O99 A;  3BDH A;  3UNY A;  2ZKT A;  1KH7 A;  2G9Y A;  1AJA A;  2W5X A;  3UO0 A;  1FSU A;  2GSO A;  3KD8 A;  4GTZ A;  4NWJ A;  1EW9 A;  5HRT A;  3BDG A;  4UOR A;  5LIA A;  3A52 A;  1EJJ A;  1ZED A;  1KH9 A;  1O98 A;  1ALH A;  1AJD A; 
#chains in the Genus database with same CATH homology
 5DLW A;  3B5Q A;  2W5V A;  4MIV A;  2IUC B;  3WAW A;  1KHJ A;  3NKP A;  5GOV A;  1ANJ A;  5EGE A;  1N2L A;  5L0E A;  1ANI A;  2GA3 A;  5IJQ A;  4KJD A;  1EQJ A;  1ZEB A;  1ALI A;  2GSN A;  4NWX A;  5DLT A;  3M8Z A;  3WAX A;  4CXK A;  1EI6 A;  3MK0 A;  1ELZ A;  1AJC A;  1K7H A;  1ED8 A;  4ZG7 A;  5L0B A;  3WAY A;  3BDF A;  2ANH A;  4UOO A;  1Y7A A;  1EW2 A;  3BDG B;  2W5W A;  4GTW A;  4ZG6 A;  4KM4 A;  3LXQ A;  1ELY A;  5LRN A;  4CXU A;  4MHX A;  3DYC A;  2IFY A;  3M8W A;  3UN5 A;  1AUK A;  3MK2 A;  3DPC A;  5GRR A;  5KXA A;  1KH4 A;  1E1Z P;  4LRD A;  2W5S A;  1KHK A;  1EW8 A;  4KJG A;  3T02 A;  1ALJ A;  4QAX A;  1HDH A;  1Y6V A;  2W8S A;  1N2K A;  3IDD A;  4LR2 A;  3OT9 A;  2XRG A;  1HQA A;  2W8D A;  3IGY B;  4LRA A;  3UN2 A;  1KHL A;  4TN0 A;  3CMR A;  4ZG9 A;  4LR9 A;  3NVL A;  2XR9 A;  2W5T A;  3NKO A;  4GTX A;  3TWZ A;  3WBH A;  3ED4 A;  4KAY A;  4UOP A;  3IGZ B;  4ZGA A;  2X98 A;  4LQY A;  4LR8 A;  5IJS A;  3Q3Q A;  5DLV A;  3NKM A;  5C66 A;  5INH A;  5LQQ A;  1KHN A;  4GTY A;  3E2D A;  2D1G A;  4UPL A;  2VQR A;  1URB A;  5LRM A;  1E33 P;  4LRF A;  3MK1 A;  4UPH A;  1URA A;  4FDJ A;  4CYR A;  3TX0 A;  4UPK A;  2GLQ A;  4LRE A;  4MY4 A;  5EGH A;  3M7V A;  1ELX A;  4UPI A;  1SHN A;  3M8Y A;  3NKN A;  5K4P A;  1ALK A;  5TJ3 A;  1AJB A;  1E2S P;  1B8J A;  2W5Q A;  2W5R A;  4B56 A;  5L0K A;  4N7T A;  3SZY A;  1ED9 A;  4LRB A;  2IUC A;  2RH6 A;  4LRC A;  4FDI A;  3NKQ A;  3NKR A;  3TG0 A;  3T01 A;  4KAV A;  5AJ9 A;  3T00 A;  3UN3 A;  4CYS A;  3SZZ A;  2GSU A;  1P49 A;  2QZU A;  1KH5 A;  1ZEF A;  3WAV A;  1SHQ A;  4LR7 A;  1HJK A;  4CXS A;  1E3C P;  4YR1 A;  1O99 A;  3BDH A;  3UNY A;  2ZKT A;  1KH7 A;  2G9Y A;  1AJA A;  2W5X A;  3UO0 A;  1FSU A;  2GSO A;  3KD8 A;  4GTZ A;  4NWJ A;  1EW9 A;  5HRT A;  3BDG A;  4UOR A;  5LIA A;  3A52 A;  1EJJ A;  1ZED A;  1KH9 A;  1O98 A;  1ALH A;  1AJD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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