1AJCA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
Knots found
sequence length
449
structure length
446
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
source organism Escherichia coli
molecule keywords ALKALINE PHOSPHATASE
total genus 160
structure length 446
sequence length 449
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-07-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajcA00
3MK2A 5L0EA 5GRRA 4KJDA 5L0BA 1Y7AA 2GSUA 4MIVA 4CXSA 1HQAA 1AJAA 1N2KA 4LRDA 3T02A 4LR7A 1P49A 1KHJA 1AUKA 1EQJA 3M7VA 3M8ZA 1KH9A 3UNYA 4UOOA 3T00A 1ZEFA 3IGZB 4UORA 5EGHA 4MY4A 3M8WA 5DLWA 4GTYA 3UO0A 2W5RA 4TN0A 4YR1A 5IJQA 2G9YA 2QZUA 2W5WA 3SZYA 4N7TA 5EGEA 4UPKA 4UPIA 5LQQA 2ANHA 1O99A 3M8YA 5C66A 1ZEBA 4UOPA 1EW9A 2IUCB 5GOVA 1URBA 3B5QA 1AJBA 3A52A 4LREA 3WAXA 4ZGAA 4CYRA 3SZZA 4FDIA 3E2DA 3OT9A 4KAVA 3MK1A 1E1ZP 4CXKA 5HRTA 5IJSA 1AJCA 3BDGB 1K7HA 3NKNA 4LRFA 2GSNA 2W8DA 5LRNA 2GLQA 3TX0A 2W5VA 4GTXA 5LIAA 4ZG7A 4FDJA 1ELXA 1ALKA 3IDDA 1ANIA 3Q3QA 1SHNA 4LRAA 1E2SP 1Y6VA 1ELZA 1HJKA 5TJ3A 4ZG9A 1ED8A 3CMRA 4KM4A 3T01A 5INHA 5AJ9A 5DLVA 1B8JA 2W5XA 1EW8A 3TWZA 1FSUA 3LXQA 1ELYA 4GTWA 4UPLA 1EW2A 2VQRA 4KJGA 2IUCA 3KD8A 3BDHA 4CXUA 2XRGA 2ZKTA 4B56A 2W5QA 4GTZA 1EI6A 1O98A 1KHLA 3MK0A 1KH4A 1AJDA 1ANJA 3IGYB 2RH6A 4CYSA 4LR8A 1KH7A 3WBHA 1ZEDA 3NKOA 4LR2A 2W5TA 1ALHA 3BDGA 5KXAA 3WAWA 3NKRA 1E33P 3DYCA 4UPHA 3BDFA 4MHXA 2D1GA 3NVLA 1KHNA 1KHKA 2GA3A 3WAYA 4LRBA 1ALIA 3NKMA 3WAVA 4LQYA 5LRMA 3UN2A 1E3CP 5L0KA 1ALJA 1URAA 1N2LA 4LR9A 3UN3A 4ZG6A 3NKPA 4NWJA 2X98A 1SHQA 4NWXA 5K4PA 3DPCA 3TG0A 2IFYA 1HDHA 2GSOA 4QAXA 3UN5A 2W5SA 1KH5A 3ED4A 4LRCA 2XR9A 5DLTA 4KAYA 2W8SA 1EJJA 1ED9A 3NKQA
chains in the Genus database with same CATH superfamily
3MK2A 5L0EA 5GRRA 4KJDA 5L0BA 1Y7AA 2GSUA 4MIVA 4CXSA 1HQAA 1AJAA 1N2KA 4LRDA 3T02A 4LR7A 1P49A 1KHJA 1AUKA 1EQJA 3M7VA 3M8ZA 1KH9A 3UNYA 4UOOA 3T00A 1ZEFA 3IGZB 4UORA 5EGHA 4MY4A 3M8WA 5DLWA 4GTYA 3UO0A 2W5RA 4TN0A 4YR1A 5IJQA 2G9YA 2QZUA 2W5WA 3SZYA 4N7TA 5EGEA 4UPKA 4UPIA 5LQQA 2ANHA 1O99A 3M8YA 5C66A 1ZEBA 4UOPA 1EW9A 2IUCB 5GOVA 1URBA 3B5QA 1AJBA 3A52A 4LREA 3WAXA 4ZGAA 4CYRA 3SZZA 4FDIA 3E2DA 3OT9A 4KAVA 3MK1A 1E1ZP 4CXKA 5HRTA 5IJSA 1AJCA 3BDGB 1K7HA 3NKNA 4LRFA 2GSNA 2W8DA 5LRNA 2GLQA 3TX0A 2W5VA 4GTXA 5LIAA 4ZG7A 4FDJA 1ELXA 1ALKA 3IDDA 1ANIA 3Q3QA 1SHNA 4LRAA 1E2SP 1Y6VA 1ELZA 1HJKA 5TJ3A 4ZG9A 1ED8A 3CMRA 4KM4A 3T01A 5INHA 5AJ9A 5DLVA 1B8JA 2W5XA 1EW8A 3TWZA 1FSUA 3LXQA 1ELYA 4GTWA 4UPLA 1EW2A 2VQRA 4KJGA 2IUCA 3KD8A 3BDHA 4CXUA 2XRGA 2ZKTA 4B56A 2W5QA 4GTZA 1EI6A 1O98A 1KHLA 3MK0A 1KH4A 1AJDA 1ANJA 3IGYB 2RH6A 4CYSA 4LR8A 1KH7A 3WBHA 1ZEDA 3NKOA 4LR2A 2W5TA 1ALHA 3BDGA 5KXAA 3WAWA 3NKRA 1E33P 3DYCA 4UPHA 3BDFA 4MHXA 2D1GA 3NVLA 1KHNA 1KHKA 2GA3A 3WAYA 4LRBA 1ALIA 3NKMA 3WAVA 4LQYA 5LRMA 3UN2A 1E3CP 5L0KA 1ALJA 1URAA 1N2LA 4LR9A 3UN3A 4ZG6A 3NKPA 4NWJA 2X98A 1SHQA 4NWXA 5K4PA 3DPCA 3TG0A 2IFYA 1HDHA 2GSOA 4QAXA 3UN5A 2W5SA 1KH5A 3ED4A 4LRCA 2XR9A 5DLTA 4KAYA 2W8SA 1EJJA 1ED9A 3NKQA
chains in the Genus database with same CATH topology
3MK2A 5L0EA 5GRRA 4KJDA 5L0BA 1Y7AA 2GSUA 4MIVA 4CXSA 1HQAA 1AJAA 1N2KA 4LRDA 3T02A 4LR7A 1P49A 1KHJA 1AUKA 1EQJA 3M7VA 3M8ZA 1KH9A 3UNYA 4UOOA 3T00A 1ZEFA 3IGZB 4UORA 5EGHA 4MY4A 3M8WA 5DLWA 4GTYA 3UO0A 2W5RA 4TN0A 4YR1A 5IJQA 2G9YA 2QZUA 2W5WA 3SZYA 4N7TA 5EGEA 4UPKA 4UPIA 5LQQA 2ANHA 1O99A 3M8YA 5C66A 1ZEBA 4UOPA 1EW9A 2IUCB 5GOVA 1URBA 3B5QA 1AJBA 3A52A 4LREA 3WAXA 4ZGAA 4CYRA 3SZZA 4FDIA 3E2DA 3OT9A 4KAVA 3MK1A 1E1ZP 4CXKA 5HRTA 5IJSA 1AJCA 3BDGB 1K7HA 3NKNA 4LRFA 2GSNA 2W8DA 5LRNA 2GLQA 3TX0A 2W5VA 4GTXA 5LIAA 4ZG7A 4FDJA 1ELXA 1ALKA 3IDDA 1ANIA 3Q3QA 1SHNA 4LRAA 1E2SP 1Y6VA 1ELZA 1HJKA 5TJ3A 4ZG9A 1ED8A 3CMRA 4KM4A 3T01A 5INHA 5AJ9A 5DLVA 1B8JA 2W5XA 1EW8A 3TWZA 1FSUA 3LXQA 1ELYA 4GTWA 4UPLA 1EW2A 2VQRA 4KJGA 2IUCA 3KD8A 3BDHA 4CXUA 2XRGA 2ZKTA 4B56A 2W5QA 4GTZA 1EI6A 1O98A 1KHLA 3MK0A 1KH4A 1AJDA 1ANJA 3IGYB 2RH6A 4CYSA 4LR8A 1KH7A 3WBHA 1ZEDA 3NKOA 4LR2A 2W5TA 1ALHA 3BDGA 5KXAA 3WAWA 3NKRA 1E33P 3DYCA 4UPHA 3BDFA 4MHXA 2D1GA 3NVLA 1KHNA 1KHKA 2GA3A 3WAYA 4LRBA 1ALIA 3NKMA 3WAVA 4LQYA 5LRMA 3UN2A 1E3CP 5L0KA 1ALJA 1URAA 1N2LA 4LR9A 3UN3A 4ZG6A 3NKPA 4NWJA 2X98A 1SHQA 4NWXA 5K4PA 3DPCA 3TG0A 2IFYA 1HDHA 2GSOA 4QAXA 3UN5A 2W5SA 1KH5A 3ED4A 4LRCA 2XR9A 5DLTA 4KAYA 2W8SA 1EJJA 1ED9A 3NKQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MK2 A;  5L0E A;  5GRR A;  4KJD A;  5L0B A;  1Y7A A;  2GSU A;  4MIV A;  4CXS A;  1HQA A;  1AJA A;  1N2K A;  4LRD A;  3T02 A;  4LR7 A;  1P49 A;  1KHJ A;  1AUK A;  1EQJ A;  3M7V A;  3M8Z A;  1KH9 A;  3UNY A;  4UOO A;  3T00 A;  1ZEF A;  3IGZ B;  4UOR A;  5EGH A;  4MY4 A;  3M8W A;  5DLW A;  4GTY A;  3UO0 A;  2W5R A;  4TN0 A;  4YR1 A;  5IJQ A;  2G9Y A;  2QZU A;  2W5W A;  3SZY A;  4N7T A;  5EGE A;  4UPK A;  4UPI A;  5LQQ A;  2ANH A;  1O99 A;  3M8Y A;  5C66 A;  1ZEB A;  4UOP A;  1EW9 A;  2IUC B;  5GOV A;  1URB A;  3B5Q A;  1AJB A;  3A52 A;  4LRE A;  3WAX A;  4ZGA A;  4CYR A;  3SZZ A;  4FDI A;  3E2D A;  3OT9 A;  4KAV A;  3MK1 A;  1E1Z P;  4CXK A;  5HRT A;  5IJS A;  1AJC A;  3BDG B;  1K7H A;  3NKN A;  4LRF A;  2GSN A;  2W8D A;  5LRN A;  2GLQ A;  3TX0 A;  2W5V A;  4GTX A;  5LIA A;  4ZG7 A;  4FDJ A;  1ELX A;  1ALK A;  3IDD A;  1ANI A;  3Q3Q A;  1SHN A;  4LRA A;  1E2S P;  1Y6V A;  1ELZ A;  1HJK A;  5TJ3 A;  4ZG9 A;  1ED8 A;  3CMR A;  4KM4 A;  3T01 A;  5INH A;  5AJ9 A;  5DLV A;  1B8J A;  2W5X A;  1EW8 A;  3TWZ A;  1FSU A;  3LXQ A;  1ELY A;  4GTW A;  4UPL A;  1EW2 A;  2VQR A;  4KJG A;  2IUC A;  3KD8 A;  3BDH A;  4CXU A;  2XRG A;  2ZKT A;  4B56 A;  2W5Q A;  4GTZ A;  1EI6 A;  1O98 A;  1KHL A;  3MK0 A;  1KH4 A;  1AJD A;  1ANJ A;  3IGY B;  2RH6 A;  4CYS A;  4LR8 A;  1KH7 A;  3WBH A;  1ZED A;  3NKO A;  4LR2 A;  2W5T A;  1ALH A;  3BDG A;  5KXA A;  3WAW A;  3NKR A;  1E33 P;  3DYC A;  4UPH A;  3BDF A;  4MHX A;  2D1G A;  3NVL A;  1KHN A;  1KHK A;  2GA3 A;  3WAY A;  4LRB A;  1ALI A;  3NKM A;  3WAV A;  4LQY A;  5LRM A;  3UN2 A;  1E3C P;  5L0K A;  1ALJ A;  1URA A;  1N2L A;  4LR9 A;  3UN3 A;  4ZG6 A;  3NKP A;  4NWJ A;  2X98 A;  1SHQ A;  4NWX A;  5K4P A;  3DPC A;  3TG0 A;  2IFY A;  1HDH A;  2GSO A;  4QAX A;  3UN5 A;  2W5S A;  1KH5 A;  3ED4 A;  4LRC A;  2XR9 A;  5DLT A;  4KAY A;  2W8S A;  1EJJ A;  1ED9 A;  3NKQ A; 
#chains in the Genus database with same CATH topology
 3MK2 A;  5L0E A;  5GRR A;  4KJD A;  5L0B A;  1Y7A A;  2GSU A;  4MIV A;  4CXS A;  1HQA A;  1AJA A;  1N2K A;  4LRD A;  3T02 A;  4LR7 A;  1P49 A;  1KHJ A;  1AUK A;  1EQJ A;  3M7V A;  3M8Z A;  1KH9 A;  3UNY A;  4UOO A;  3T00 A;  1ZEF A;  3IGZ B;  4UOR A;  5EGH A;  4MY4 A;  3M8W A;  5DLW A;  4GTY A;  3UO0 A;  2W5R A;  4TN0 A;  4YR1 A;  5IJQ A;  2G9Y A;  2QZU A;  2W5W A;  3SZY A;  4N7T A;  5EGE A;  4UPK A;  4UPI A;  5LQQ A;  2ANH A;  1O99 A;  3M8Y A;  5C66 A;  1ZEB A;  4UOP A;  1EW9 A;  2IUC B;  5GOV A;  1URB A;  3B5Q A;  1AJB A;  3A52 A;  4LRE A;  3WAX A;  4ZGA A;  4CYR A;  3SZZ A;  4FDI A;  3E2D A;  3OT9 A;  4KAV A;  3MK1 A;  1E1Z P;  4CXK A;  5HRT A;  5IJS A;  1AJC A;  3BDG B;  1K7H A;  3NKN A;  4LRF A;  2GSN A;  2W8D A;  5LRN A;  2GLQ A;  3TX0 A;  2W5V A;  4GTX A;  5LIA A;  4ZG7 A;  4FDJ A;  1ELX A;  1ALK A;  3IDD A;  1ANI A;  3Q3Q A;  1SHN A;  4LRA A;  1E2S P;  1Y6V A;  1ELZ A;  1HJK A;  5TJ3 A;  4ZG9 A;  1ED8 A;  3CMR A;  4KM4 A;  3T01 A;  5INH A;  5AJ9 A;  5DLV A;  1B8J A;  2W5X A;  1EW8 A;  3TWZ A;  1FSU A;  3LXQ A;  1ELY A;  4GTW A;  4UPL A;  1EW2 A;  2VQR A;  4KJG A;  2IUC A;  3KD8 A;  3BDH A;  4CXU A;  2XRG A;  2ZKT A;  4B56 A;  2W5Q A;  4GTZ A;  1EI6 A;  1O98 A;  1KHL A;  3MK0 A;  1KH4 A;  1AJD A;  1ANJ A;  3IGY B;  2RH6 A;  4CYS A;  4LR8 A;  1KH7 A;  3WBH A;  1ZED A;  3NKO A;  4LR2 A;  2W5T A;  1ALH A;  3BDG A;  5KXA A;  3WAW A;  3NKR A;  1E33 P;  3DYC A;  4UPH A;  3BDF A;  4MHX A;  2D1G A;  3NVL A;  1KHN A;  1KHK A;  2GA3 A;  3WAY A;  4LRB A;  1ALI A;  3NKM A;  3WAV A;  4LQY A;  5LRM A;  3UN2 A;  1E3C P;  5L0K A;  1ALJ A;  1URA A;  1N2L A;  4LR9 A;  3UN3 A;  4ZG6 A;  3NKP A;  4NWJ A;  2X98 A;  1SHQ A;  4NWX A;  5K4P A;  3DPC A;  3TG0 A;  2IFY A;  1HDH A;  2GSO A;  4QAX A;  3UN5 A;  2W5S A;  1KH5 A;  3ED4 A;  4LRC A;  2XR9 A;  5DLT A;  4KAY A;  2W8S A;  1EJJ A;  1ED9 A;  3NKQ A; 
#chains in the Genus database with same CATH homology
 3MK2 A;  5L0E A;  5GRR A;  4KJD A;  5L0B A;  1Y7A A;  2GSU A;  4MIV A;  4CXS A;  1HQA A;  1AJA A;  1N2K A;  4LRD A;  3T02 A;  4LR7 A;  1P49 A;  1KHJ A;  1AUK A;  1EQJ A;  3M7V A;  3M8Z A;  1KH9 A;  3UNY A;  4UOO A;  3T00 A;  1ZEF A;  3IGZ B;  4UOR A;  5EGH A;  4MY4 A;  3M8W A;  5DLW A;  4GTY A;  3UO0 A;  2W5R A;  4TN0 A;  4YR1 A;  5IJQ A;  2G9Y A;  2QZU A;  2W5W A;  3SZY A;  4N7T A;  5EGE A;  4UPK A;  4UPI A;  5LQQ A;  2ANH A;  1O99 A;  3M8Y A;  5C66 A;  1ZEB A;  4UOP A;  1EW9 A;  2IUC B;  5GOV A;  1URB A;  3B5Q A;  1AJB A;  3A52 A;  4LRE A;  3WAX A;  4ZGA A;  4CYR A;  3SZZ A;  4FDI A;  3E2D A;  3OT9 A;  4KAV A;  3MK1 A;  1E1Z P;  4CXK A;  5HRT A;  5IJS A;  1AJC A;  3BDG B;  1K7H A;  3NKN A;  4LRF A;  2GSN A;  2W8D A;  5LRN A;  2GLQ A;  3TX0 A;  2W5V A;  4GTX A;  5LIA A;  4ZG7 A;  4FDJ A;  1ELX A;  1ALK A;  3IDD A;  1ANI A;  3Q3Q A;  1SHN A;  4LRA A;  1E2S P;  1Y6V A;  1ELZ A;  1HJK A;  5TJ3 A;  4ZG9 A;  1ED8 A;  3CMR A;  4KM4 A;  3T01 A;  5INH A;  5AJ9 A;  5DLV A;  1B8J A;  2W5X A;  1EW8 A;  3TWZ A;  1FSU A;  3LXQ A;  1ELY A;  4GTW A;  4UPL A;  1EW2 A;  2VQR A;  4KJG A;  2IUC A;  3KD8 A;  3BDH A;  4CXU A;  2XRG A;  2ZKT A;  4B56 A;  2W5Q A;  4GTZ A;  1EI6 A;  1O98 A;  1KHL A;  3MK0 A;  1KH4 A;  1AJD A;  1ANJ A;  3IGY B;  2RH6 A;  4CYS A;  4LR8 A;  1KH7 A;  3WBH A;  1ZED A;  3NKO A;  4LR2 A;  2W5T A;  1ALH A;  3BDG A;  5KXA A;  3WAW A;  3NKR A;  1E33 P;  3DYC A;  4UPH A;  3BDF A;  4MHX A;  2D1G A;  3NVL A;  1KHN A;  1KHK A;  2GA3 A;  3WAY A;  4LRB A;  1ALI A;  3NKM A;  3WAV A;  4LQY A;  5LRM A;  3UN2 A;  1E3C P;  5L0K A;  1ALJ A;  1URA A;  1N2L A;  4LR9 A;  3UN3 A;  4ZG6 A;  3NKP A;  4NWJ A;  2X98 A;  1SHQ A;  4NWX A;  5K4P A;  3DPC A;  3TG0 A;  2IFY A;  1HDH A;  2GSO A;  4QAX A;  3UN5 A;  2W5S A;  1KH5 A;  3ED4 A;  4LRC A;  2XR9 A;  5DLT A;  4KAY A;  2W8S A;  1EJJ A;  1ED9 A;  3NKQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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