1ANIA

Alkaline phosphatase (d153h, k328h)
Total Genus 161
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
161
Knots found
sequence length
446
structure length
446
Chain Sequence
MPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDHQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
publication title Mutations at positions 153 and 328 in Escherichia coli alkaline phosphatase provide insight towards the structure and function of mammalian and yeast alkaline phosphatases.
pubmed doi rcsb
molecule keywords ALKALINE PHOSPHATASE
molecule tags Alkaline phosphatase
source organism Escherichia coli
total genus 161
structure length 446
sequence length 446
chains with identical sequence B
other databases KnotProt 2.0: S +31
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aniA00
3SZYA 1E33P 1N2KA 1KHJA 4CYRA 1ANIA 4B56A 3NVLA 4MY4A 1ALIA 3ED4A 4NWJA 1URBA 3IGYB 5TJ3A 1EI6A 3UNYA 3LXQA 3WAWA 1ZEBA 4LR2A 1EW9A 3NKPA 4KJDA 4ZG9A 4MHXA 5DLVA 2GSUA 1AJDA 2G9YA 4UORA 4UOOA 1SHNA 3MK2A 4NWXA 4MIVA 3BDGA 4LQYA 4KJGA 4CYSA 1O99A 3UN2A 5LQQA 3SZZA 4UPHA 3WAXA 3WAYA 5C66A 2GSNA 4TN0A 4N7TA 2ANHA 1AJAA 3MK1A 3DYCA 5L0BA 3TG0A 3DPCA 3T01A 3M8ZA 1KHLA 2XRGA 4CXUA 2W5RA 4UPKA 4UPIA 3Q3QA 1ED8A 3TWZA 3UN5A 2IFYA 1ALHA 4GTXA 3CMRA 1AJBA 1EJJA 1HQAA 4LRDA 1ELZA 1ELYA 2GLQA 2XR9A 4LR9A 2RH6A 5INHA 4KM4A 2W8SA 4GTWA 3WBHA 4GTZA 3MK0A 1E3CP 5EGEA 3A52A 5HRTA 1O98A 1ED9A 2IUCA 4LRCA 3NKRA 2GA3A 2W5WA 3TX0A 1AUKA 2W5SA 1SHQA 2D1GA 4FDIA 1FSUA 4UOPA 4LRAA 1EQJA 5IJQA 4KAVA 4YR1A 3WAVA 5LIAA 4LR7A 3UO0A 1K7HA 5DLTA 1KH7A 1ELXA 3BDGB 3M8WA 4ZGAA 1ZEDA 2W8DA 1KH5A 3IDDA 4LRBA 1HJKA 4LR8A 1AJCA 1N2LA 3T02A 4CXSA 4FDJA 5EGHA 1ALKA 5DLWA 1P49A 2X98A 3KD8A 3OT9A 1ANJA 4GTYA 1KH4A 1KH9A 1Y6VA 1E2SP 5L0EA 3IGZB 2W5VA 1HDHA 3UN3A 2QZUA 1Y7AA 1EW8A 4CXKA 3M8YA 3NKNA 2VQRA 5GRRA 1ALJA 5IJSA 1KHNA 1B8JA 3B5QA 5GOVA 3T00A 5AJ9A 2W5TA 1EW2A 3M7VA 3NKQA 5KXAA 3NKMA 5LRMA 4ZG7A 3BDFA 2GSOA 3E2DA 4LREA 2W5XA 1E1ZP 2W5QA 3BDHA 4KAYA 5L0KA 5K4PA 5LRNA 1KHKA 2ZKTA 1ZEFA 4UPLA 4ZG6A 4LRFA 1URAA 3NKOA 2IUCB 4QAXA
chains in the Genus database with same CATH superfamily
3SZYA 1E33P 1N2KA 1KHJA 4CYRA 1ANIA 4B56A 3NVLA 4MY4A 1ALIA 3ED4A 4NWJA 1URBA 3IGYB 5TJ3A 1EI6A 3UNYA 3LXQA 3WAWA 1ZEBA 4LR2A 1EW9A 3NKPA 4KJDA 4ZG9A 4MHXA 5DLVA 2GSUA 1AJDA 2G9YA 4UORA 4UOOA 1SHNA 3MK2A 4NWXA 4MIVA 3BDGA 4LQYA 4KJGA 4CYSA 1O99A 3UN2A 5LQQA 3SZZA 4UPHA 3WAXA 3WAYA 5C66A 2GSNA 4TN0A 4N7TA 2ANHA 1AJAA 3MK1A 3DYCA 5L0BA 3TG0A 3DPCA 3T01A 3M8ZA 1KHLA 2XRGA 4CXUA 2W5RA 4UPKA 4UPIA 3Q3QA 1ED8A 3TWZA 3UN5A 2IFYA 1ALHA 4GTXA 3CMRA 1AJBA 1EJJA 1HQAA 4LRDA 1ELZA 1ELYA 2GLQA 2XR9A 4LR9A 2RH6A 5INHA 4KM4A 2W8SA 4GTWA 3WBHA 4GTZA 3MK0A 1E3CP 5EGEA 3A52A 5HRTA 1O98A 1ED9A 2IUCA 4LRCA 3NKRA 2GA3A 2W5WA 3TX0A 1AUKA 2W5SA 1SHQA 2D1GA 4FDIA 1FSUA 4UOPA 4LRAA 1EQJA 5IJQA 4KAVA 4YR1A 3WAVA 5LIAA 4LR7A 3UO0A 1K7HA 5DLTA 1KH7A 1ELXA 3BDGB 3M8WA 4ZGAA 1ZEDA 2W8DA 1KH5A 3IDDA 4LRBA 1HJKA 4LR8A 1AJCA 1N2LA 3T02A 4CXSA 4FDJA 5EGHA 1ALKA 5DLWA 1P49A 2X98A 3KD8A 3OT9A 1ANJA 4GTYA 1KH4A 1KH9A 1Y6VA 1E2SP 5L0EA 3IGZB 2W5VA 1HDHA 3UN3A 2QZUA 1Y7AA 1EW8A 4CXKA 3M8YA 3NKNA 2VQRA 5GRRA 1ALJA 5IJSA 1KHNA 1B8JA 3B5QA 5GOVA 3T00A 5AJ9A 2W5TA 1EW2A 3M7VA 3NKQA 5KXAA 3NKMA 5LRMA 4ZG7A 3BDFA 2GSOA 3E2DA 4LREA 2W5XA 1E1ZP 2W5QA 3BDHA 4KAYA 5L0KA 5K4PA 5LRNA 1KHKA 2ZKTA 1ZEFA 4UPLA 4ZG6A 4LRFA 1URAA 3NKOA 2IUCB 4QAXA
chains in the Genus database with same CATH topology
3SZYA 1E33P 1N2KA 1KHJA 4CYRA 1ANIA 4B56A 3NVLA 4MY4A 1ALIA 3ED4A 4NWJA 1URBA 3IGYB 5TJ3A 1EI6A 3UNYA 3LXQA 3WAWA 1ZEBA 4LR2A 1EW9A 3NKPA 4KJDA 4ZG9A 4MHXA 5DLVA 2GSUA 1AJDA 2G9YA 4UORA 4UOOA 1SHNA 3MK2A 4NWXA 4MIVA 3BDGA 4LQYA 4KJGA 4CYSA 1O99A 3UN2A 5LQQA 3SZZA 4UPHA 3WAXA 3WAYA 5C66A 2GSNA 4TN0A 4N7TA 2ANHA 1AJAA 3MK1A 3DYCA 5L0BA 3TG0A 3DPCA 3T01A 3M8ZA 1KHLA 2XRGA 4CXUA 2W5RA 4UPKA 4UPIA 3Q3QA 1ED8A 3TWZA 3UN5A 2IFYA 1ALHA 4GTXA 3CMRA 1AJBA 1EJJA 1HQAA 4LRDA 1ELZA 1ELYA 2GLQA 2XR9A 4LR9A 2RH6A 5INHA 4KM4A 2W8SA 4GTWA 3WBHA 4GTZA 3MK0A 1E3CP 5EGEA 3A52A 5HRTA 1O98A 1ED9A 2IUCA 4LRCA 3NKRA 2GA3A 2W5WA 3TX0A 1AUKA 2W5SA 1SHQA 2D1GA 4FDIA 1FSUA 4UOPA 4LRAA 1EQJA 5IJQA 4KAVA 4YR1A 3WAVA 5LIAA 4LR7A 3UO0A 1K7HA 5DLTA 1KH7A 1ELXA 3BDGB 3M8WA 4ZGAA 1ZEDA 2W8DA 1KH5A 3IDDA 4LRBA 1HJKA 4LR8A 1AJCA 1N2LA 3T02A 4CXSA 4FDJA 5EGHA 1ALKA 5DLWA 1P49A 2X98A 3KD8A 3OT9A 1ANJA 4GTYA 1KH4A 1KH9A 1Y6VA 1E2SP 5L0EA 3IGZB 2W5VA 1HDHA 3UN3A 2QZUA 1Y7AA 1EW8A 4CXKA 3M8YA 3NKNA 2VQRA 5GRRA 1ALJA 5IJSA 1KHNA 1B8JA 3B5QA 5GOVA 3T00A 5AJ9A 2W5TA 1EW2A 3M7VA 3NKQA 5KXAA 3NKMA 5LRMA 4ZG7A 3BDFA 2GSOA 3E2DA 4LREA 2W5XA 1E1ZP 2W5QA 3BDHA 4KAYA 5L0KA 5K4PA 5LRNA 1KHKA 2ZKTA 1ZEFA 4UPLA 4ZG6A 4LRFA 1URAA 3NKOA 2IUCB 4QAXA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3SZY A;  1E33 P;  1N2K A;  1KHJ A;  4CYR A;  1ANI A;  4B56 A;  3NVL A;  4MY4 A;  1ALI A;  3ED4 A;  4NWJ A;  1URB A;  3IGY B;  5TJ3 A;  1EI6 A;  3UNY A;  3LXQ A;  3WAW A;  1ZEB A;  4LR2 A;  1EW9 A;  3NKP A;  4KJD A;  4ZG9 A;  4MHX A;  5DLV A;  2GSU A;  1AJD A;  2G9Y A;  4UOR A;  4UOO A;  1SHN A;  3MK2 A;  4NWX A;  4MIV A;  3BDG A;  4LQY A;  4KJG A;  4CYS A;  1O99 A;  3UN2 A;  5LQQ A;  3SZZ A;  4UPH A;  3WAX A;  3WAY A;  5C66 A;  2GSN A;  4TN0 A;  4N7T A;  2ANH A;  1AJA A;  3MK1 A;  3DYC A;  5L0B A;  3TG0 A;  3DPC A;  3T01 A;  3M8Z A;  1KHL A;  2XRG A;  4CXU A;  2W5R A;  4UPK A;  4UPI A;  3Q3Q A;  1ED8 A;  3TWZ A;  3UN5 A;  2IFY A;  1ALH A;  4GTX A;  3CMR A;  1AJB A;  1EJJ A;  1HQA A;  4LRD A;  1ELZ A;  1ELY A;  2GLQ A;  2XR9 A;  4LR9 A;  2RH6 A;  5INH A;  4KM4 A;  2W8S A;  4GTW A;  3WBH A;  4GTZ A;  3MK0 A;  1E3C P;  5EGE A;  3A52 A;  5HRT A;  1O98 A;  1ED9 A;  2IUC A;  4LRC A;  3NKR A;  2GA3 A;  2W5W A;  3TX0 A;  1AUK A;  2W5S A;  1SHQ A;  2D1G A;  4FDI A;  1FSU A;  4UOP A;  4LRA A;  1EQJ A;  5IJQ A;  4KAV A;  4YR1 A;  3WAV A;  5LIA A;  4LR7 A;  3UO0 A;  1K7H A;  5DLT A;  1KH7 A;  1ELX A;  3BDG B;  3M8W A;  4ZGA A;  1ZED A;  2W8D A;  1KH5 A;  3IDD A;  4LRB A;  1HJK A;  4LR8 A;  1AJC A;  1N2L A;  3T02 A;  4CXS A;  4FDJ A;  5EGH A;  1ALK A;  5DLW A;  1P49 A;  2X98 A;  3KD8 A;  3OT9 A;  1ANJ A;  4GTY A;  1KH4 A;  1KH9 A;  1Y6V A;  1E2S P;  5L0E A;  3IGZ B;  2W5V A;  1HDH A;  3UN3 A;  2QZU A;  1Y7A A;  1EW8 A;  4CXK A;  3M8Y A;  3NKN A;  2VQR A;  5GRR A;  1ALJ A;  5IJS A;  1KHN A;  1B8J A;  3B5Q A;  5GOV A;  3T00 A;  5AJ9 A;  2W5T A;  1EW2 A;  3M7V A;  3NKQ A;  5KXA A;  3NKM A;  5LRM A;  4ZG7 A;  3BDF A;  2GSO A;  3E2D A;  4LRE A;  2W5X A;  1E1Z P;  2W5Q A;  3BDH A;  4KAY A;  5L0K A;  5K4P A;  5LRN A;  1KHK A;  2ZKT A;  1ZEF A;  4UPL A;  4ZG6 A;  4LRF A;  1URA A;  3NKO A;  2IUC B;  4QAX A; 
#chains in the Genus database with same CATH topology
 3SZY A;  1E33 P;  1N2K A;  1KHJ A;  4CYR A;  1ANI A;  4B56 A;  3NVL A;  4MY4 A;  1ALI A;  3ED4 A;  4NWJ A;  1URB A;  3IGY B;  5TJ3 A;  1EI6 A;  3UNY A;  3LXQ A;  3WAW A;  1ZEB A;  4LR2 A;  1EW9 A;  3NKP A;  4KJD A;  4ZG9 A;  4MHX A;  5DLV A;  2GSU A;  1AJD A;  2G9Y A;  4UOR A;  4UOO A;  1SHN A;  3MK2 A;  4NWX A;  4MIV A;  3BDG A;  4LQY A;  4KJG A;  4CYS A;  1O99 A;  3UN2 A;  5LQQ A;  3SZZ A;  4UPH A;  3WAX A;  3WAY A;  5C66 A;  2GSN A;  4TN0 A;  4N7T A;  2ANH A;  1AJA A;  3MK1 A;  3DYC A;  5L0B A;  3TG0 A;  3DPC A;  3T01 A;  3M8Z A;  1KHL A;  2XRG A;  4CXU A;  2W5R A;  4UPK A;  4UPI A;  3Q3Q A;  1ED8 A;  3TWZ A;  3UN5 A;  2IFY A;  1ALH A;  4GTX A;  3CMR A;  1AJB A;  1EJJ A;  1HQA A;  4LRD A;  1ELZ A;  1ELY A;  2GLQ A;  2XR9 A;  4LR9 A;  2RH6 A;  5INH A;  4KM4 A;  2W8S A;  4GTW A;  3WBH A;  4GTZ A;  3MK0 A;  1E3C P;  5EGE A;  3A52 A;  5HRT A;  1O98 A;  1ED9 A;  2IUC A;  4LRC A;  3NKR A;  2GA3 A;  2W5W A;  3TX0 A;  1AUK A;  2W5S A;  1SHQ A;  2D1G A;  4FDI A;  1FSU A;  4UOP A;  4LRA A;  1EQJ A;  5IJQ A;  4KAV A;  4YR1 A;  3WAV A;  5LIA A;  4LR7 A;  3UO0 A;  1K7H A;  5DLT A;  1KH7 A;  1ELX A;  3BDG B;  3M8W A;  4ZGA A;  1ZED A;  2W8D A;  1KH5 A;  3IDD A;  4LRB A;  1HJK A;  4LR8 A;  1AJC A;  1N2L A;  3T02 A;  4CXS A;  4FDJ A;  5EGH A;  1ALK A;  5DLW A;  1P49 A;  2X98 A;  3KD8 A;  3OT9 A;  1ANJ A;  4GTY A;  1KH4 A;  1KH9 A;  1Y6V A;  1E2S P;  5L0E A;  3IGZ B;  2W5V A;  1HDH A;  3UN3 A;  2QZU A;  1Y7A A;  1EW8 A;  4CXK A;  3M8Y A;  3NKN A;  2VQR A;  5GRR A;  1ALJ A;  5IJS A;  1KHN A;  1B8J A;  3B5Q A;  5GOV A;  3T00 A;  5AJ9 A;  2W5T A;  1EW2 A;  3M7V A;  3NKQ A;  5KXA A;  3NKM A;  5LRM A;  4ZG7 A;  3BDF A;  2GSO A;  3E2D A;  4LRE A;  2W5X A;  1E1Z P;  2W5Q A;  3BDH A;  4KAY A;  5L0K A;  5K4P A;  5LRN A;  1KHK A;  2ZKT A;  1ZEF A;  4UPL A;  4ZG6 A;  4LRF A;  1URA A;  3NKO A;  2IUC B;  4QAX A; 
#chains in the Genus database with same CATH homology
 3SZY A;  1E33 P;  1N2K A;  1KHJ A;  4CYR A;  1ANI A;  4B56 A;  3NVL A;  4MY4 A;  1ALI A;  3ED4 A;  4NWJ A;  1URB A;  3IGY B;  5TJ3 A;  1EI6 A;  3UNY A;  3LXQ A;  3WAW A;  1ZEB A;  4LR2 A;  1EW9 A;  3NKP A;  4KJD A;  4ZG9 A;  4MHX A;  5DLV A;  2GSU A;  1AJD A;  2G9Y A;  4UOR A;  4UOO A;  1SHN A;  3MK2 A;  4NWX A;  4MIV A;  3BDG A;  4LQY A;  4KJG A;  4CYS A;  1O99 A;  3UN2 A;  5LQQ A;  3SZZ A;  4UPH A;  3WAX A;  3WAY A;  5C66 A;  2GSN A;  4TN0 A;  4N7T A;  2ANH A;  1AJA A;  3MK1 A;  3DYC A;  5L0B A;  3TG0 A;  3DPC A;  3T01 A;  3M8Z A;  1KHL A;  2XRG A;  4CXU A;  2W5R A;  4UPK A;  4UPI A;  3Q3Q A;  1ED8 A;  3TWZ A;  3UN5 A;  2IFY A;  1ALH A;  4GTX A;  3CMR A;  1AJB A;  1EJJ A;  1HQA A;  4LRD A;  1ELZ A;  1ELY A;  2GLQ A;  2XR9 A;  4LR9 A;  2RH6 A;  5INH A;  4KM4 A;  2W8S A;  4GTW A;  3WBH A;  4GTZ A;  3MK0 A;  1E3C P;  5EGE A;  3A52 A;  5HRT A;  1O98 A;  1ED9 A;  2IUC A;  4LRC A;  3NKR A;  2GA3 A;  2W5W A;  3TX0 A;  1AUK A;  2W5S A;  1SHQ A;  2D1G A;  4FDI A;  1FSU A;  4UOP A;  4LRA A;  1EQJ A;  5IJQ A;  4KAV A;  4YR1 A;  3WAV A;  5LIA A;  4LR7 A;  3UO0 A;  1K7H A;  5DLT A;  1KH7 A;  1ELX A;  3BDG B;  3M8W A;  4ZGA A;  1ZED A;  2W8D A;  1KH5 A;  3IDD A;  4LRB A;  1HJK A;  4LR8 A;  1AJC A;  1N2L A;  3T02 A;  4CXS A;  4FDJ A;  5EGH A;  1ALK A;  5DLW A;  1P49 A;  2X98 A;  3KD8 A;  3OT9 A;  1ANJ A;  4GTY A;  1KH4 A;  1KH9 A;  1Y6V A;  1E2S P;  5L0E A;  3IGZ B;  2W5V A;  1HDH A;  3UN3 A;  2QZU A;  1Y7A A;  1EW8 A;  4CXK A;  3M8Y A;  3NKN A;  2VQR A;  5GRR A;  1ALJ A;  5IJS A;  1KHN A;  1B8J A;  3B5Q A;  5GOV A;  3T00 A;  5AJ9 A;  2W5T A;  1EW2 A;  3M7V A;  3NKQ A;  5KXA A;  3NKM A;  5LRM A;  4ZG7 A;  3BDF A;  2GSO A;  3E2D A;  4LRE A;  2W5X A;  1E1Z P;  2W5Q A;  3BDH A;  4KAY A;  5L0K A;  5K4P A;  5LRN A;  1KHK A;  2ZKT A;  1ZEF A;  4UPL A;  4ZG6 A;  4LRF A;  1URA A;  3NKO A;  2IUC B;  4QAX A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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